Journal of affective disorders最新文献

{"title":"The effectiveness of mindfulness-based interventions on menopausal symptoms: A systematic review and meta-analysis of randomized controlled trials","authors":"Hongjuan Wang ,&nbsp;Hui Wang ,&nbsp;Jojo Yan Yan Kwok ,&nbsp;Siyuan Tang ,&nbsp;Mei Sun","doi":"10.1016/j.jad.2025.04.029","DOIUrl":"10.1016/j.jad.2025.04.029","url":null,"abstract":"<div><h3>Background</h3><div>Menopause, a crucial transitioning stage for women, can significantly impact mood and wellbeing. We aimed to systematically examine the effectiveness of Mindfulness-based interventions (MBIs) on health outcomes, including menopausal symptoms, quality of life (QOL), sleep quality, anxiety, depressive symptoms, stress, mindfulness levels, and female sexual function index.</div></div><div><h3>Methods</h3><div>Eight databases were searched from inception to November 4, 2024 for randomized controlled trials. Two researchers independently selected, extracted, and appraised trials using the Cochrane Collaboration's ‘risk of bias’ tool. Meta-analysis, subgroup analysis, leave-one-out sensitivity analysis, and meta-regression were performed using Stata 18.0. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) was used to assess the quality of evidence.</div></div><div><h3>Results</h3><div>A total of 19 studies (1670 participants) published between 2011 and 2024 were identified. Of these, 18 studies were included in the meta-analysis. Compared with control group, The pooled analysis demonstrated that MBIs had statistically significant effects on menopausal symptoms (SMD, −2.10; 95 % CI, −3.49 to −0.70), QOL (SMD, −0.88; 95 % CI, −1.67 to −0.09), sleep quality (SMD, −0.92; 95 % CI, −1.65 to −0.20), anxiety (SMD, −1.03; 95 % CI, −1.42 to −0.66), depressive symptoms (SMD, −0.91; 95 % CI, −1.30 to −0.53), stress (SMD, −0.85; 95 % CI, −1.55 to −0.15), and mindfulness levels (SMD, 1.19; 95 % CI, 0.35 to 2.02). The overall quality of evidence for all pooled estimates were graded as low and moderate due to methodological limitations and small sample size. The low attrition rate (6 %) and relatively high adherence rate (79 %) highlight the acceptability of MBIs.</div></div><div><h3>Conclusions</h3><div>This systematic review and meta-analysis support using of MBIs to improve health outcomes in menopausal women. Rigorous randomized controlled trials with extended follow-up are needed to elucidate the mechanisms linking MBIs to menopausal health and strengthen evidence for clinical application.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 337-349"},"PeriodicalIF":4.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut–brain axis modulation by sudachi peel extract enhances resilience to chronic social defeat stress in mice","authors":"Jiajing Shan ,&nbsp;Youge Qu ,&nbsp;Kenji Hashimoto","doi":"10.1016/j.jad.2025.04.027","DOIUrl":"10.1016/j.jad.2025.04.027","url":null,"abstract":"<div><h3>Background</h3><div>Sudachitin, an anti-inflammatory compound from <em>Citrus sudachi</em> peel, may influence stress resilience. We examined whether sudachi peel extract affects depression-like behaviors and gut microbiota dysbiosis in mice subjected to chronic social defeat stress (CSDS).</div></div><div><h3>Methods</h3><div>First, we examined the effect of sudachitin on depression-like behavior and plasma interleukin-6 (IL-6) levels following lipopolysaccharide (LPS, 0.5 mg/kg) administration. Next, we investigated whether supplementation with sudachi peel extract could modulate the gut microbiota dysbiosis induced by CSDS.</div></div><div><h3>Results</h3><div>Sudachitin prevented LPS-induced depression-like behavior and the rise in plasma IL-6. In control mice, CSDS increased IL-6, induced splenomegaly, and caused anhedonia-like behavior. These changes were absent in the sudachi peel extract group. Although alpha-diversity of the gut microbiota remained abnormal under CSDS, beta-diversity was significantly altered by sudachi peel extract. Moreover, plasma IL-6 levels and Iba1 expression in the prefrontal cortex correlated with the relative abundance of certain gut bacteria.</div></div><div><h3>Limitations</h3><div>The exact mechanisms behind the resilience-promoting effects of sudachi peel extract remain unclear.</div></div><div><h3>Conclusion</h3><div>Sudachi peel extract supplementation enhances resilience to CSDS by preventing anhedonia, reducing plasma IL-6 levels and splenomegaly, and modulating gut microbiota composition. Further research is needed to clarify these anti-inflammatory pathways and the roles of additional pro-inflammatory cytokines.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 401-409"},"PeriodicalIF":4.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent types of cognitive emotion regulation strategies among middle school students in China and its effect on depressive symptoms","authors":"Jichang Guo ,&nbsp;Yanpei Pan","doi":"10.1016/j.jad.2025.04.021","DOIUrl":"10.1016/j.jad.2025.04.021","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the latent categories of cognitive emotion regulation strategies among middle school students in China and their effect on depressive symptoms.</div></div><div><h3>Methods</h3><div>The 535 (13.51 ± 0.93 years; 55.33 % males, 44.67 % females) middle school students from southwestern regions in China were recruited using <em>Cognitive Emotion Regulation Questionnaire-Chinese Version</em> and <em>Patient Health Questionnaire-9</em>. Correlation analysis, latent profile analysis and Bolck-Croon-Hagenaars (BCH) analysis were used to explore the latent categories of cognitive emotion regulation strategies and to analyze the relationship between latent categories and depressive symptoms.</div></div><div><h3>Results</h3><div>The depressive symptoms prevalence among middle school students was 30.47 %. There are four latent types of cognitive emotion regulation strategies: <em>weak cognitive emotion regulation strategy</em> (<em>Weak CERS</em>), <em>high positive cognitive emotion regulation strategy</em> (<em>High Positive CERS</em>), <em>moderate and slightly negative cognitive emotion regulation strategy (Moderate and Slightly negative CERS)</em> and <em>high negative cognitive emotion regulation strategy</em> (<em>High Negative CERS</em>). The BCH analysis shows the scores of depressive symptoms are significantly different among four profiles of <em>CERQ-C</em> (Wald χ² = 173.04, <em>p</em> &lt; 0.001) and the scores of depressive symptoms are obviously different between the four profiles (Wald χ² = 4.67–171.37, <em>p</em>s &lt; 0.05) except between profile 2 and 3 (Wald χ² = 1.376, <em>p</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>The level of depressive symptoms among middle school students from southwestern regions in China is relatively high, and their cognitive emotion regulation strategies can be divided into four types, having significant effects on depressive symptoms.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 381-387"},"PeriodicalIF":4.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of antidepressant-associated seizures from 1967 to 2023: A comparative analysis of the international pharmacovigilance database","authors":"Hanseul Cho ,&nbsp;Kyeongmin Lee ,&nbsp;Sheng-Min Wang ,&nbsp;Hayeon Lee ,&nbsp;Soeun Kim ,&nbsp;Tae Hyeon Kim ,&nbsp;Guillaume Fond ,&nbsp;Laurent Boyer ,&nbsp;Louis Jacob ,&nbsp;Selin Woo ,&nbsp;Suein Choi ,&nbsp;Dong Keon Yon","doi":"10.1016/j.jad.2025.04.024","DOIUrl":"10.1016/j.jad.2025.04.024","url":null,"abstract":"<div><h3>Background</h3><div>Although antidepressants have been implicated in seizure risk, comprehensive safety data examining this risk across different antidepressants remains limited.</div></div><div><h3>Methods</h3><div>Data from Vigibase, an international pharmacovigilance database, encompassing 131,255,418 reports from 1967 to 2023, was analyzed. Reporting odds ratio (ROR) and information component (IC) were calculates to identify disproportionate associations between 17 antidepressants and seizures.</div></div><div><h3>Results</h3><div>Among 2,275,638 reports on antidepressants, 23,331 reported seizures. Antidepressants as a whole were associated with higher reporting frequency of seizures compared with all medications. Among antidepressant classes, tricyclic antidepressants (TCA; ROR [95 % CI]: 2.71 [2.58–2.84]; IC [IC0.25] 1.42 [1.34]), were the most frequently reported in combination with seizures, followed by selective serotonin reuptake inhibitors (SSRIs; 2.27 [2.22–2.32]; 1.16 [1.13]) and serotonin-norepinephrine reuptake inhibitors (SNRIs; 1.31 [1.27–1.36]; 0.39 [0.33]). Regarding individual antidepressants, agomelatine and desvenlafaxine were the only medications without a significant disproportionate association with seizures. Among the remaining antidepressants, bupropion (8.57 [8.34–8.80]; 3.04 [3.00]) and clomipramine (4.69 [4.29–5.13]; 2.20 [2.05]) had the highest disproportionality measure estimates, whereas vortioxetine and duloxetine had the lowest disproportionality in reporting. Escitalopram (2.17 [2.04–2.31]; 1.11 [1.01]), the active enantiomer of citalopram, and desvenlafaxine (0.93 [0.82–1.05]; −0.11 [−0.31]), the active metabolite of venlafaxine, were less frequently reported for seizures compared to their parent compounds.</div></div><div><h3>Conclusion</h3><div>Our findings align with earlier studies indicating that SNRIs and SSRIs carry a lower risk of seizures, whereas bupropion and clomipramine are linked to a higher risk. Agomelatine, vortioxetine, and SNRIs like desvenlafaxine and duloxetine may potentially be safe alternatives.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 215-223"},"PeriodicalIF":4.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased risk of suicide among individuals with chronic obstructive pulmonary disease: A nationwide cohort study in Korea","authors":"Sang Hyuk Kim ,&nbsp;Ji-Yong Moon ,&nbsp;Taehee Kim ,&nbsp;Jin-Hyung Jung ,&nbsp;Kyungdo Han ,&nbsp;Kyung Hoon Min ,&nbsp;Hyun Lee","doi":"10.1016/j.jad.2025.04.022","DOIUrl":"10.1016/j.jad.2025.04.022","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have established that individuals with chronic obstructive pulmonary disease (COPD) have an increased risk of suicidal behaviors. However, it is uncertain which subgroups of individuals with COPD are at higher risk of suicide.</div></div><div><h3>Method</h3><div>We analyzed data from the Korean National Health Insurance Service. The exposure was COPD, and the outcome was death by suicide. Participants were followed until their date of death by suicide, the censoring date, or December 31, 2021, whichever came first. A Fine-Gray proportional hazards model for subdistribution was used to determine the associations between COPD and death by suicide.</div></div><div><h3>Results</h3><div>During a median follow-up of 11.3 years (interquartile range, 11.1–11.6 years), individuals with COPD had an increased risk of death by suicide compared to those without (adjusted subdistribution hazard ratio [aSHR] = 1.20, 95 % confidence interval [CI] = 1.08–1.32). When stratified by the presence or absence of potential risk factors and COPD, the risk of suicide was highest in the COPD population with current smoking habits ≥20 PY (aSHR = 1.71, 95 % CI = 1.39–2.12), depression (aSHR = 2.46, 95 % CI = 1.97–3.08), and anxiety (aSHR = 2.71, 95 % CI = 1.87–3.92) compared to their corresponding reference groups (non-COPD population without the corresponding potential risk factors).</div></div><div><h3>Conclusions</h3><div>COPD increased the risk of death by suicide. This risk was particularly pronounced when current heavy smoking habits, depression, and anxiety coexisted with COPD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 507-513"},"PeriodicalIF":4.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of first attempt of suicide in early adolescence using machine learning","authors":"Chen Huang ,&nbsp;Yanling Yue ,&nbsp;Zimao Wang ,&nbsp;Yong-Jin Liu ,&nbsp;Nisha Yao ,&nbsp;Wenting Mu","doi":"10.1016/j.jad.2025.03.201","DOIUrl":"10.1016/j.jad.2025.03.201","url":null,"abstract":"<div><h3>Background</h3><div>Suicide is the second leading cause of death among early adolescents, yet the first onset of suicide attempts during this critical developmental period remains poorly understood. This study aimed to identify key characteristics associated with the first suicide attempt in early adolescence and to develop a predictive model for assessing individual risk.</div></div><div><h3>Methods</h3><div>We used data from the Adolescent Brain Cognitive Development Study, a longitudinal, population-based study in the US. The analysis focused on a cohort of 4,238 early adolescents (aged 11–12 years) who had no prior history of suicide attempts. To predict the onset of a first suicide attempt over the subsequent two years (2020–2022), we developed an extremely randomized tree model, incorporating 87 potential predictors from diverse bio-psycho-social domains pertinent to adolescent development.</div></div><div><h3>Results</h3><div>Among the 4,238 adolescents, 163 (3.8%) reported their first suicide attempt within the subsequent two years. Our predictive model demonstrated good discriminative ability, achieving an AUC of 0.82 (95% CI [0.79, 0.85]), with a sensitivity of 0.82 and a specificity of 0.69 at the optimized threshold. Key predictors included sex assigned at birth, sexual orientation, negative affect, internalizing and attention problems, and lifetime suicidal ideation, along with other significant factors from multiple domains.</div></div><div><h3>Conclusions</h3><div>These findings highlight the utility of machine learning algorithms in identifying predictors of suicide attempts among early adolescents. The insights gained from this study may contribute to the development of tailored screening tools and preventive interventions aimed at mitigating suicide risk in this vulnerable population.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 1-9"},"PeriodicalIF":4.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inequalities in the utilisation of mental health services amongst different clusters of Australian children and adolescents","authors":"Nahida Afroz ,&nbsp;Enamul Kabir ,&nbsp;Khorshed Alam","doi":"10.1016/j.jad.2025.04.001","DOIUrl":"10.1016/j.jad.2025.04.001","url":null,"abstract":"<div><h3>Aims</h3><div>To investigate the inequalities in mental health service utilisation amongst socio-demographic classes of Australian children and adolescents diagnosed with major mental and/or behavioural disorders, and suicidality.</div></div><div><h3>Methods</h3><div>A nationally representative sample of Australian children and adolescents was assessed, comprising 2898 parent and 1736 child participants. The Bolck, Croon, and Hagenaars (BCH) method was applied to pre-identified latent classes to determine adjusted class membership. Logistic regressions and predictive marginal analysis examined associations between these classes and mental health service utilisation in three scenarios: overall, with mental and/or behavioural disorders, and with suicidality.</div></div><div><h3>Results</h3><div>Children and adolescents in Class 1 (Underprivileged) characterised by low socio-economic status and non-intact families showed the highest prevalence of mental and/or behavioural disorders and suicidality and the highest utilisation of mental health services. Classes 2 (Low-Skilled but Cohesive) and 4 (Affluent Single Parent) had higher prevalence rates of disorders and suicidality than Classes 3 (Stable Middle Class) and 5 (Privileged). However, Class 4 utilised services less than Classes 3 and 5, while Class 2 had the lowest utilisation amongst all classes, despite higher disorder prevalence.</div></div><div><h3>Conclusions</h3><div>The study highlights significant disparities in mental health service utilisation across socio-demographic classes. Children and adolescents from underprivileged and non-intact family backgrounds face the highest burden of mental health issues but also utilise services more frequently. In contrast, Classes 2 and 4, despite higher disorder prevalence, underutilise services, indicating barriers to access. Government initiatives should focus on improving parental awareness, family structures, and socio-economic conditions to enhance service utilisation and reduce mental health disparities.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 121-130"},"PeriodicalIF":4.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between C-reactive protein and neuroimaging findings in mood disorders: A review of structural and diffusion MRI studies","authors":"Parya Valizadeh ,&nbsp;Payam Jannatdoust ,&nbsp;Delaram J. Ghadimi ,&nbsp;Mohammadreza Tahamtan ,&nbsp;Kimia Darmiani ,&nbsp;Shirin Shahsavarhaghighi ,&nbsp;Sahar Rezaei ,&nbsp;Mohammad Hadi Aarabi ,&nbsp;Giulia Cattarinussi ,&nbsp;Fabio Sambataro ,&nbsp;Guido Nosari ,&nbsp;Giuseppe Delvecchio","doi":"10.1016/j.jad.2025.03.175","DOIUrl":"10.1016/j.jad.2025.03.175","url":null,"abstract":"<div><h3>Background</h3><div>Mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), often share structural brain alterations, which may be linked to peripheral inflammation. In this regard, C-Reactive Protein (CRP) has been associated with these alterations. This review explores the relationship between CRP levels and neuroimaging findings in mood disorders using structural and diffusion Magnetic Resonance Imaging (MRI).</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, a systematic search was conducted through Scopus, PubMed, Web of Science, and Embase before September 2024, focusing on studies evaluating associations between CRP levels and structural and/or microstructural brain alterations in mood disorders.</div></div><div><h3>Results</h3><div>The present systematic review included 20 studies examining the associations between peripheral CRP levels or DNA methylation-based CRP (DNAm CRP) signatures and structural brain alterations in mood disorders. Findings showed considerable variability; however, consistent patterns emerged, linking higher CRP levels to reduced grey matter volumes and cortical thinning, particularly in the prefrontal cortex (PFC), hippocampus, entorhinal cortex, insula, and caudate. Diffusion-based imaging consistently indicated reduced white matter integrity, with significant effects in key tracts such as the internal capsule, cingulum bundle, and corpus callosum (CC).</div></div><div><h3>Conclusions</h3><div>Overall, these findings suggest that systemic inflammation, reflected by elevated CRP or DNAm CRP, contributes to structural alterations indicative of neurodegeneration and compromised axonal integrity in mood disorders. Discrepancies among studies highlight potential influences of disease severity, treatment history, and distinct inflammatory mediators. Future research employing standardized imaging protocols and longitudinal designs is essential to clarify inflammation's mechanistic roles and identify reliable biomarkers of structural brain alterations in mood disorders.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 643-658"},"PeriodicalIF":4.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lithium and valproate affect subcortical brain volumes in individuals with bipolar disorder: Mega-analysis of 235 individuals","authors":"Naoki Hashimoto ,&nbsp;Naohiro Okada ,&nbsp;Masaki Fukunaga ,&nbsp;Kiyotaka Nemoto ,&nbsp;Kenichiro Miura ,&nbsp;Junya Matsumoto ,&nbsp;Shuhei Ishikawa ,&nbsp;Hisashi Narita ,&nbsp;Kentaro Morita ,&nbsp;Yuka Yasuda ,&nbsp;Toshiharu Kamishikiryo ,&nbsp;Kenichiro Harada ,&nbsp;Maeri Yamamoto ,&nbsp;Kazutaka Ohi ,&nbsp;Toshio Matsubara ,&nbsp;Yoji Hirano ,&nbsp;Go Okada ,&nbsp;Khin K. Tha ,&nbsp;Osamu Abe ,&nbsp;Toshiaki Onitsuka ,&nbsp;Ryota Hashimoto","doi":"10.1016/j.jad.2025.04.019","DOIUrl":"10.1016/j.jad.2025.04.019","url":null,"abstract":"<div><h3>Introduction</h3><div>The mega-analysis conducted by the ENIGMA Bipolar Disorder Working Group revealed significant volume increment effects of lithium on the hippocampus in individual with bipolar disorder. However, the study did not assess other medications and other subcortical regions.</div></div><div><h3>Methods</h3><div>Data of 235 individuals with bipolar disorder were taken from a mega-analysis conducted by the COCORO consortium in Japan. The effects of psychotropic prescriptions (lithium, valproate, antipsychotics, antidepressants, benzodiazepines) were assessed using a linear mixed-effects model with volumes of subcortical structures as dependent variables, and age, sex, intracranial volume, duration of illness, and psychotropic prescriptions as independent variables; the type of protocol was incorporated as a random effect.</div></div><div><h3>Results</h3><div>Prescriptions of lithium was associated with larger left amygdala volume (Effect size (ES, Cohen's d) = 0.36, p = 0.001). Prescriptions of valproate was associated with smaller left amygdala volume (ES = -0.45, p = 0.001), and larger bilateral ventricle volumes (ES = 0.68, p &lt; 0.001 (left), ES = 0.70, p &lt; 0.001 (right)). Prescriptions of antipsychotics were associated with larger left globus pallidus volume (ES = 0.33, p = 0.014) and smaller left hippocampus volume (ES = -0.33, p = 0.024). Prescriptions of benzodiazepines were associated with smaller left lateral ventricle (ES = -0.40, p = 0.029). Prescriptions of antidepressants were associated with smaller right accumbens volume (ES = -0.22, p = 0.043), bilateral caudate volumes (ES = -0.38, p = 0.013 (left), ES = -0.25, p = 0.050 (right)) and right putamen volume (ES = -0.23, p = 0.024).</div></div><div><h3>Conclusion</h3><div>We confirmed the association between prescription of valproate and smaller amygdala and larger lateral ventricle volumes in a large sample for the first time. Large sample size, uniform data collection methodology, and robust statistical analysis are strengths of the current study.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 115-120"},"PeriodicalIF":4.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjusting the composition of gut microbiota prevents the development of post-stroke depression by regulating the gut-brain axis in mice","authors":"Su-ting Jiang ,&nbsp;Meng-qing Wang ,&nbsp;Li Gao ,&nbsp;Qi-chun Zhang ,&nbsp;Chao Tang ,&nbsp;Yin-feng Dong","doi":"10.1016/j.jad.2025.03.195","DOIUrl":"10.1016/j.jad.2025.03.195","url":null,"abstract":"<div><div>Disturbances in gut microbiota contribute to an imbalanced gut-brain axis, which is critical for post-stroke depression (PSD), while the underlying mechanisms remain unclear. The objective of this study was to examine the effects of modifying gut microbiota through antibiotic treatment (ABX) and fecal microbiota transplantation (FMT) on the progression of PSD. The PSD model was established by occluding the middle cerebral artery (MCAO), followed by a four-week isolated housing and restraint stress initiated three days after MCAO. For ABX, the PSD mice received antibiotic water for four weeks. While another group of PSD mice underwent FMT or fluoxetine (FLX) for four weeks. At day 35 post-MCAO, behavioral tests were conducted. Results indicated ABX and FMT significantly altered the composition of intestinal flora caused by PSD, all the treatments markedly attenuated anxiety- and depressive-like behaviors and inflammation in the gut and brain. ABX obviously alleviated PSD-induced disorder of intestinal barrier, decreased mRNA levels of TNF-α, IL-1β and IL-6, and decreased CD4⁺ cells in the colon. While FMT significantly decreased CD8⁺ cells and increased the goblet cells in colon. Furthermore, both ABX and FMT could reduce activated microglia and pro-inflammatory cytokines in the brain, alleviate decreased Nissl's bodies in the hippocampus, and reverse the decreases in 5-HT, Glu and DA in the striatum caused by PSD. Unlike ABX, FMT was similar to FLX. These findings suggest homeostasis of gut microbiota is indispensable for the development of PSD; adjusting the gut microbiota significantly improves PSD with enhanced functions of gut-brain axis.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 242-259"},"PeriodicalIF":4.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}