Journal of affective disorders最新文献

{"title":"Multidimensional stress and self-harm in Chinese preadolescents: A cross-sectional study.","authors":"Ming Ai, Wo Wang, Jian-Mei Chen, Jing-Lan He, Qi Zhang, Su Hong, Yao Gan, Jun Cao, Da-Qin Ding, Yi-Yao Tian, Jin-Hui Hu, Jiao-Jiao Xiang, Shuang Zhang, Xin-Zhu Lin, Yu-Jia Chen, Ya-Han Zhou, Bing Hu, Li Kuang, Xiao-Ming Xu","doi":"10.1016/j.jad.2024.12.034","DOIUrl":"10.1016/j.jad.2024.12.034","url":null,"abstract":"<p><strong>Background: </strong>Limited research has been conducted on self-harm among preadolescents in China. This study investigated the influence of multidimensional stress on high levels of self-harm behavior in preadolescents.</p><p><strong>Method: </strong>This large-scale cross-sectional study of 7-14-year-old primary school students in grades 3-6 was conducted in Southwest China between September and December 2020. Data on sociodemographic characteristics and multidimensional stressors were collected and analyzed.</p><p><strong>Results: </strong>The self-harm prevalence among the 48,117 preadolescents was 13.6 % (n = 6561), with respective prevalence rates of 13.2 % in males and 14.1 % in females. Chi-square and binary logistic regression analyses were employed. The most important factors for self-harm were ranked as follows: high academic pressure (OR = 2.00, 95 % CI 1.90-2.09), poor relationship with parents (OR = 1.89, 95 % CI 1.78-2.00), frequently being bullied (OR = 1.53, 95 % CI 1.47-1.60), early-onset menstruation (OR = 1.33, 95 % CI 1.22-1.46), frequent smartphone use (OR = 1.31, 95 % CI 1.26-1.37), poor classmate relationships (OR = 1.31, 95 % CI 1.24-1.38), poor relationship between parents (OR = 1.11, 95 % CI 1.08-1.14), poor family financial situation (OR = 1.11, 95 % CI 1.05-1.17), and being bullied within the past 1 month (OR = 1.05, 95 % CI 1.02-1.07).</p><p><strong>Limitations: </strong>The limitations of this study include its cross-sectional design, the use of a non-structured questionnaire, the subjectivity of some items, the reliance on a single question about self-harm, and the possibility that participants may have concealed the true nature of their behaviors.</p><p><strong>Conclusion: </strong>Preadolescents in China exhibited high rates of self-harm behaviors. It is recommended that schools and families pay more attention to the mental health of preadolescent students, especially with regard to self-harm, and develop targeted interventions to address this issue.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"370-376"},"PeriodicalIF":4.9,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between adverse experiences and longitudinal allostatic load changes with the depression symptoms trajectories in middle-aged and older adults in China: A longitudinal study.","authors":"Xiujuan Li, Mingyi Dong, Wenjing Xia, Can Huang, Taoyun Zheng, Xinhong Zhu","doi":"10.1016/j.jad.2024.11.082","DOIUrl":"10.1016/j.jad.2024.11.082","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the associations between adverse childhood experiences (ACEs), adverse adulthood experiences (AAEs), allostatic load (AL) changes, and later depression symptoms trajectories in middle-aged and older Chinese longitudinally.</p><p><strong>Methods: </strong>1921 individuals aged ≥45 years at baseline were included from the China Health and Retirement Longitudinal Study (CHARLS). Measures included ACEs, AAEs, depression symptoms scores, health-related factors, and demographic characteristics. AL changes were assessed by the difference in AL scores between wave 3 (2015) and wave 1(2011).</p><p><strong>Results: </strong>Compared to consistently low trajectory, 2 or more ACEs (OR 1.78, 95 % CI 1.28-2.46), 2 or more AAEs (OR 1.82, 95 % CI 1.26-2.64), decreasing metabolic AL over time (OR 0.63, 95 % CI 0.46-0.86), increasing inflammatory AL over time (OR 1.60, 95 % CI 1.07-2.37), and decreasing renal AL over time (OR 1.38, 95 % CI 1.01-1.87) were associated with the low-moderate depression symptoms trajectory. Furthermore, 2 or more ACEs (OR 1.48, 95 % CI 1.10-2.00), 2 or more AAEs (OR 1.85, 95 % CI 1.32-2.60), decreasing metabolic AL over time (OR 0.75, 95 % CI 0.57-1.00), increasing inflammatory AL over time (OR 1.69, 95 % CI 1.19-2.42) were associated with the high-moderate depression symptoms trajectory.</p><p><strong>Conclusion: </strong>Experiencing more ACEs and AAEs was associated with higher depression symptoms trajectories. Moreover, participants with decreasing metabolic AL over time showed a low depression symptoms trajectory, while those with increasing inflammatory AL over time and decreasing renal AL over time showed a worse depression symptoms trajectory. These findings highlighted the physiological damage caused by stress on mental health outcomes.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"377-385"},"PeriodicalIF":4.9,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-based analysis of early cortical gyrification and thickness alterations in treatment-Naïve, first-episode depressive patients during emerging adulthood.","authors":"Azi Shen, Kaiyu Shi, Qiudong Xia, Wenyue Gong, Yinghong Huang, Yiwen Wang, Qinghua Zhai, Rui Yan, Zhijian Yao, Qing Lu","doi":"10.1016/j.jad.2024.12.003","DOIUrl":"10.1016/j.jad.2024.12.003","url":null,"abstract":"<p><strong>Background: </strong>Extensive research, predominantly in adults, has highlighted structural brain variations among patients with major depressive disorder (MDD). However, emerging adults, who undergo significant cortical reshaping and are highly vulnerable to depression, receive relatively little attention, despite reporting a higher prevalence of childhood trauma experiences. This study examines cortical gyrification and thickness in emerging adults with first-episode, treatment-naïve MDD, with the objective of investigating their association with childhood trauma.</p><p><strong>Methods: </strong>Eighty-six emerging adults diagnosed with MDD, aged 18 to 25, and eighty-one healthy controls (HCs), underwent T1-MRI scans. We compared the local gyrification index (LGI) and cortical thickness (CT) between the two groups. Subsequently, we examined the relationship between the LGI and CT in clusters showing differences and childhood trauma as well as clinical characteristics in emerging adults with MDD.</p><p><strong>Results: </strong>Compared to HCs, MDD showed decreased LGI in the bilateral superior frontal cortices (SFC) and CT in the left pericalcarine cortex (PCC), while an increase in CT was observed in the left lateral orbitofrontal cortex (OFC). The reduction in LGI of the right SFC and the decrease in CT of the left PCC are associated with childhood trauma. Notably these brain abnormalities were not significantly associated with depressive and anxiety symptoms, or the duration of illness.</p><p><strong>Conclusion: </strong>Abnormal cortical development observed in emerging adults with first episode depression may act as a predisposing factor for depression, irrespective of clinical manifestations, and may be linked to childhood trauma.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"402-408"},"PeriodicalIF":4.9,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the Bipolar Spectrum Diagnostic Scale in depressed youth.","authors":"Dylan Hammond, Sue Cotton, Simon Rice, Sarah E Hetrick, Paul Amminger, Olivia Dean, Seetal Dodd, Patrick McGorry, Andrew M Chanen, Christopher G Davey, Michael Berk, Aswin Ratheesh","doi":"10.1016/j.jad.2024.12.018","DOIUrl":"10.1016/j.jad.2024.12.018","url":null,"abstract":"<p><strong>Background: </strong>Youth with depression may be at a higher risk of developing bipolar disorder (BD). Self-reported, dimensional measures, like the Bipolar Spectrum Diagnostic Scale (BSDS), aim to assess for BD in these groups. We explored properties of this instrument within a cohort of depressed, help-seeking youth.</p><p><strong>Methods: </strong>We used baseline data from two randomized controlled trials for depressed youth (aged 15-25 years) who had no history of BD or psychosis and who completed the BSDS (n = 240; mean Age = 19.9 years, SD = 2.7; Female = 57 %). Structured diagnostic assessments were repeated at 26-weeks to detect new-onset BD. We examined false-positive rates for concurrent BD using established thresholds on the BSDS, utilised factor analyses to determine its underlying structure, and explored associations between the BSDS and demographic, clinical, and personality variables using linear regressions.</p><p><strong>Results: </strong>False-positives rates were high. Most (60 %) participants scored above BSDS thresholds at baseline, though none developed BD over the 26-week study period. A three-factor model best fit BSDS items, representing depression, mania, and lability factors. BSDS total, mania and lability sub-scale scores were associated with similar characteristics, with a different pattern of association for the BSDS depression subscale.</p><p><strong>Limitations: </strong>With no long-term follow-up of the current sample nor a separate bipolar youth sample, we were unable to determine the overall discriminant validity, sensitivity, or longer-term predictive validity of the BSDS.</p><p><strong>Conclusion: </strong>At recommended thresholds, BSDS has high false positive rates for detecting current BD in youth with moderate to severe depression, especially with mental state or personality disorder comorbidities.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"347-355"},"PeriodicalIF":4.9,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in emotion regulation strategy use in major depressive disorder: Flexibility or volatility?","authors":"Danfei Hu, Maya Tamir","doi":"10.1016/j.jad.2024.12.027","DOIUrl":"10.1016/j.jad.2024.12.027","url":null,"abstract":"<p><strong>Background: </strong>Emotion regulation is critical for psychological health. Adaptive emotion regulation, in particular, requires the ability to flexibly use different strategies to meet situational demands. Such flexibility is often reflected in greater variability in everyday emotion regulation strategy use. Research on strategy variability has, to date, been positively associated with some emotional and psychological outcomes, but such research has exclusively focused on healthy individuals. Our investigation examines whether variability in emotion regulation strategy use and its implications differ between individuals with Major Depressive Disorder (MDD) and healthy controls.</p><p><strong>Method: </strong>Using ecological momentary assessments (EMA), we assessed variability in emotion regulation strategy use (i.e., between-strategy variability) and its implications in individuals with current MDD and healthy controls (Ns = 94 and 90). Participants completed six surveys per day for 10 days, rating their emotional experiences and emotion regulation strategy use. They also rated indices of psychological health daily.</p><p><strong>Results: </strong>Individuals with MDD had higher emotion regulation strategy variability than healthy controls. In healthy controls, higher strategy variability was linked to greater emotion regulation success and was unrelated to daily depressive symptoms. However, in individuals with MDD, higher strategy variability was not only unrelated or even negatively linked to emotion regulation success, but it was also associated with higher daily depressive symptoms.</p><p><strong>Limitations: </strong>We did not assess the fit between regulatory strategies and contexts, and only included self-report measures collected through smartphones.</p><p><strong>Conclusion: </strong>Variability in emotion regulation strategy use may capture adaptive flexibility among healthy individuals, but maladaptive volatility among individuals with MDD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"306-313"},"PeriodicalIF":4.9,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomised controlled feasibility trial of Behavioural activation as a treatment for people with diabetes and depression: (DiaDeM feasibility trial).","authors":"Naveed Ahmed, Gerardo A Zavala, Faraz Siddiqui, Faiza Aslam, Ada Keding, Shannon Halmkan, Saima Afaq, Hannah Maria Jennings, Ashraful Anas, Sanjit K Shaha, Kazi Moriom Jahan, Abdul Kuddus, Zara Nisar, Simon M Walker, Anum Naz, Hira Shakoor, Asima K Niazi, Rowena Jacobs, Karen Coales, Kishwar Azad, Edward Fottrell, Zia Ul Haq, David Ekers, Najma Siddiqi, Catherine Hewitt","doi":"10.1016/j.jad.2024.11.079","DOIUrl":"10.1016/j.jad.2024.11.079","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of evidence on effective treatments for depression in people with T2DM, particularly in Low and Middle-Income Countries (LMICs). This study aims to test the feasibility and acceptability of a culturally adapted Behavioural Activation (BA) intervention (DiaDeM) for people with depression and T2DM in two South Asian LMICs.</p><p><strong>Methods: </strong>A multicountry, individually randomised-controlled feasibility trial was conducted from March 2022 to November 2022. We recruited adults from diabetes healthcare facilities in Bangladesh and Pakistan with a diagnosis of depression and T2DM. Consenting individuals were randomised to either optimised usual care or the DiaDeM intervention, which comprised six BA sessions delivered by non-mental health facilitators over six to twelve weeks. Participants were followed up at three and six months post-randomisation. The feasibility and acceptability of recruitment and retention, intervention delivery, and data collection were assessed. A mixed-methods process evaluation was also performed to inform the main trial.</p><p><strong>Results: </strong>The DiaDeM feasibility trial successfully recruited 128 participants, with 85 % retention at six months follow-up. The majority of participants engaged with the intervention, demonstrating good adherence to the Behavioural Activation (BA) sessions. Data completeness for key outcomes, including depression severity and HbA1c levels, was high across all time points (>90 %). The process evaluation showed high acceptability of the intervention, with participants reporting increased motivation and improved management of both T2DM and depression.</p><p><strong>Discussion: </strong>Good recruitment and retention rates, completeness of data collection, and high acceptability of the intervention showed that it would be feasible to undertake a full-scale trial.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"333-346"},"PeriodicalIF":4.9,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive control impairment in suicide behaviors: what do we know? A systematic review and meta-analysis of Stroop in suicide behaviors.","authors":"Stéphane Richard-Devantoy, Ayla Inja, Marina Dicker, Josie-Anne Bertrand, Gustavo Turecki, M Orri, John G Keilp","doi":"10.1016/j.jad.2024.12.009","DOIUrl":"10.1016/j.jad.2024.12.009","url":null,"abstract":"<p><strong>Background: </strong>Suicidal behavior results from a complex interplay between stressful events and vulnerability factors, including cognitive deficits. Poorer performance on the Stroop task, a measure of cognitive control, has been associated with suicidal behavior in numerous studies. The objective was to conduct an updated systematic review of the literature on the Stroop task as a neuropsychological test of vulnerability to suicidal acts in patients with mood and other psychiatric disorders, while also looking at how the type (classic versus emotional) or the version (paper or computerized) of the Stroop task, as well as the characteristics of the patient (clinical population, age, sex) moderated the Stroop effect.</p><p><strong>Methods: </strong>A search on Medline, Embase, PsycInfo databases, and article references was performed. 53 studies (6781 participants) met the selection criteria. Interference time and errors of the Stroop Test were assessed in at least 3 studies to be analyzed. Moderators, such as the type (classic versus emotional) of the Stroop task and the characteristics of the patient (clinical population, age, sex) were also assessed.</p><p><strong>Results: </strong>Interference time on Stroop performance was lower in suicide attempters than in patient controls (g = 0.20; 95%CI [0.10-0.30]) and healthy controls (g = 0.79; 95 % CI [0.29-1.29]), with patient controls scoring lower than healthy controls (g = -0.63; 95%CI [-1.01-0.25]). This was moderated by age and having a mood disorder. In terms of interference errors, suicide attempters performed worse than healthy controls (g = 0.57; 95%CI [0.01-1.15]) but did not perform differently from patient controls (g = 0.20; 95 % CI [-0.06-0.45]). Patient controls also did not score differently than healthy controls (g = -0.18; 95 % CI [-0.54-0.18]). There was a significant moderation effect for the type (i.e., original Stroop task) and version (i.e., paper format) of the Stroop task, and for some characteristics of the patient (i.e., older patients and having a mood disorder).</p><p><strong>Conclusions: </strong>Cognitive control impairment was associated with a history of suicidal behavior in patients, especially in older populations and those with mood disorders, however this result was moderated by outcome measure (interference time vs. errors), the type (i.e., original Stroop task) and the version (i.e., paper format) of the Stroop task. Cognitive control processes may be an important factor of suicidal vulnerability. Choosing the right neurocognitive test in the right population to detect suicide vulnerability is important direction for future research.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"358-369"},"PeriodicalIF":4.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who is at risk of long-term subjective memory impairment after electroconvulsive therapy?","authors":"Elsa Tornhamre, Åsa Hammar, Pia Nordanskog, Axel Nordenskjöld","doi":"10.1016/j.jad.2024.12.028","DOIUrl":"10.1016/j.jad.2024.12.028","url":null,"abstract":"<p><strong>Background: </strong>Electroconvulsive therapy (ECT) is an effective treatment for depression with potential transient cognitive side effects. However, subjective memory impairment can extend over a long period after ECT.</p><p><strong>Objectives: </strong>This study aimed to assess potential risk factors for long-term subjective memory impairment 6 months after ECT and to explore if the associations are mediated by depressive symptoms.</p><p><strong>Methods: </strong>This registry-based study used the Swedish National Quality Register for ECT and other national registers. Long-term subjective memory worsening was defined as a minimum 2-step worsening on the memory item from the comprehensive psychopathological rating scale (CPRS-M) from before ECT to 6 months after ECT. Changes on the scale were also analyzed in continuous models. Statistical methods used were logistic regression and linear regression analyses in univariable and multivariable models.</p><p><strong>Results: </strong>The study population consisted of 1498 patients. Subjective memory worsening occurred in 25.2 % of the population. Long-term subjective memory worsening was associated with more depressive symptoms and lower education levels. No association could be found related to ECT technical factors. The associations between age and psychiatric comorbidities with subjective memory worsening were mediated by depressive symptoms.</p><p><strong>Conclusion: </strong>Patients can be informed that depressive symptoms are one of the biggest contributing factors to long-term subjective memory impairment after ECT. A successful treatment is therefore important to minimize the long-term experience of memory deficits. The number of sessions or ECT technical factors do not seem to be associated with long-term subjective memory impairment.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"324-332"},"PeriodicalIF":4.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic functional brain connectivity in adolescent anxiety: Associations with behavioral phenotypes and cross-syndrome network features.","authors":"Xavier Yan Heng Lim, Lizhu Luo, Junhong Yu","doi":"10.1016/j.jad.2024.12.015","DOIUrl":"10.1016/j.jad.2024.12.015","url":null,"abstract":"<p><strong>Background: </strong>Considerable research has mapped the human brain networks implicated in anxiety. Yet, less is known about the intrinsic features of the brain implicated in adolescent anxiety and their generalizability to affective and behavioral problems. To this end, we investigated the intrinsic functional connectomes associated with anxiety, their associations with behavioral phenotypes of clinical interest, and the cross-syndrome overlap between the anxiety network and other affective syndromes in an adolescent sample.</p><p><strong>Methods: </strong>We used the Boston Adolescent Neuroimaging of Depression and Anxiety (BANDA) dataset which comprises 203 clinical and healthy adolescents aged 14-17. Participants underwent a resting-state magnetic resonance imaging scan and completed the Child Behavior Checklist (CBCL) and Behavioral Inhibition/Activation System scale. Using network-based statistics, we identified functional networks associated with anxiety and other behavioral syndromes. The anxiety network strengths were then correlated with behavioral measures.</p><p><strong>Results: </strong>A significant resting-state functional network associated with anxiety was identified, largely characterized by hyperconnectivity between the somatomotor and both the default mode network and subcortical regions. Network strengths derived from the anxiety network were significantly correlated to various behavioral syndromes, including internalizing and externalizing tendencies. Cross-syndrome overlapping edges were also observed in networks of internalizing disorders, more prominently post-traumatic stress syndromes.</p><p><strong>Conclusions: </strong>Our results revealed the functional connectomes characteristic of anxiety in adolescents. This resting-state functional network was also predictive of and shared similar features with behavioral syndromes typically associated with anxiety-related disorders, providing evidence that the high comorbidity of anxiety with other clinical conditions may have a neurobiological basis.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"251-261"},"PeriodicalIF":4.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal localisation of a theory-based anxiety disorder biomarker - Goal conflict specific rhythmicity.","authors":"Shabah M Shadli, Bruce R Russell, Veema Lodhia, Ian J Kirk, Paul Glue, Neil McNaughton","doi":"10.1016/j.jad.2024.12.007","DOIUrl":"10.1016/j.jad.2024.12.007","url":null,"abstract":"<p><strong>Purpose: </strong>Anxiety disorders are a major global issue. Diagnosis via symptoms, not biological causes, delivers poor treatment outcomes. Our frontal EEG biomarker, Goal Conflict Specific Rhythmicity (GCSR; 4-12 Hz), developed from our long-standing detailed neuropsychological theory of anxiety processes, is reduced by all chemical types of selective anxiolytic and is high in cases across a range of currently diagnosed anxiety disorders.</p><p><strong>Methods: </strong>We assessed frontal sources of GCSR, recording scalp EEG at either low resolution (Experiment 1, 32 channels, University of Otago, ♀:33, ♂:16) or high resolution (Experiment 2, 128 channels, University of Auckland, ♀:10, ♂:8) in healthy participants performing a Stop Signal Task to generate GCSR as previously.</p><p><strong>Principal results: </strong>sLORETA demonstrated GCSR sources consistently in the right inferior frontal gyrus and, more strongly but less consistently, medial frontal gyrus. Variation was consistent with that of stopping in the same Stop Signal Task, depending on task demands.</p><p><strong>Major conclusions: </strong>The sources of GCSR are consistent with our theory that hippocampal output receives goal information, detects conflict, and returns a negative biasing signal to the areas encoding goals in the current task. They match the variation in the control of stopping when response urgency changes. GCSR appears to index a biological type of anxiety unlike any current diagnosis and should help improve accuracy of diagnosis - anchored to actions of selective anxiolytic drugs. This task-related frontal \"theta\" rhythmicity provides proof-of-concept for further development of our theory of the neuropsychology of anxiety in direct human tests.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"287-295"},"PeriodicalIF":4.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}