Journal of affective disorders最新文献

{"title":"Development of an explainable machine learning model for predicting depression in adolescent girls with non-suicidal self-injury: A cross-sectional multicenter study","authors":"Ben Niu ,&nbsp;Mengjie Wan ,&nbsp;Yongjie Zhou","doi":"10.1016/j.jad.2025.03.080","DOIUrl":"10.1016/j.jad.2025.03.080","url":null,"abstract":"<div><div>Non-suicidal self-injury (NSSI) in adolescent girls is a critical predictor of subsequent depression and suicide risk, yet current tools lack both accuracy and clinical interpretability. We developed the first explainable machine learning model integrating multicenter psychosocial data to predict depression among Chinese adolescent girls with NSSI, addressing the critical need for culturally tailored risk stratification tools. In this cross - sectional observational study, our model was developed using data from 14 hospitals. We used five categories of data as predictors, including individual, family, school, psychosocial, and behavioral and lifestyle factors. We compared seven machine learning models and selected the best one to develop final model and the Shapley Additive exPlanations (SHAP) method were used to explain model prediction. The Random Forest (RF) model was compared against six other machine learning algorithms. We assessed the discrimination using the area under receiver operating characteristic (AUROC) with 95 % CIs. Using the development dataset (<em>n</em> = 1163) and predictive model building process, a simplified model containing only the top 20 features had similar predictive performance to the full model, the RF model outperformed six algorithms (AUROC = 0.964 [0.945–0.975]), demonstrating superior discriminative power and robustness. The top ten risk predictors were Borderline personality, Rumination, Perceived stress, Hopelessness, Self-esteem, Sleep quality, Loneliness, Resilience, Parental care, and Problem-focused coping. We developed a three-tiered, color-coded web-based clinical tool to operationalize predictions, enabling real-time risk stratification and personalized interventions. Our study bridges machine learning and clinical interpretability to advance precision mental health interventions for vulnerable adolescent populations.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 690-702"},"PeriodicalIF":4.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intersections among the domains of physical activity and depressive symptoms among Brazilian adults","authors":"Fabio Fortunato Brasil de Carvalho ,&nbsp;Andrei Gabriel Chiconato ,&nbsp;Nathalia Assis Augusto ,&nbsp;Jessica Vertuan Rufino ,&nbsp;Mathias Roberto Loch","doi":"10.1016/j.jad.2025.03.081","DOIUrl":"10.1016/j.jad.2025.03.081","url":null,"abstract":"<div><h3>Background</h3><div>Physical activity (PA) has been recommended as a way of preventing and treating depressive symptoms; however, this association seems to depend on multiple factors. The objective of this study was to analyze the possible associations between various intersections among the PA domains and depressive symptoms in Brazilian adults.</div></div><div><h3>Methods</h3><div>Data were collected from 52,475 individuals who were ≥ 18 years old. The experience of depressive symptoms was used as the dependent variable, while the various PA domains (including all possible intersections among them) constituted the independent variable.</div></div><div><h3>Results</h3><div>The ‘leisure time’ domain was associated with the best results, revealing that this domain serves as a protective factor with respect to depressive symptoms, especially when it occurs in isolation, highlighting that the risk is 32 % lower in both sexes, or in combination with ‘work’. When the ‘work’ domain was combined with domains other than ‘leisure time’, it proved to be more of a risk factor than a protective factor. Individuals who were active in all four domains exhibited a greater likelihood of experiencing depressive symptoms (53 %), than did individuals who were inactive. Among men, the likelihood of experiencing depressive symptoms was higher among individuals who were active in the ‘transportation and household’ domains (277 %), while among women, the likelihood of such symptoms was higher among individuals who were active in the ‘work and household’ domains (127 %).</div></div><div><h3>Conclusion</h3><div>The results of this research indicate that the relationship between PA and depressive symptoms may differ depending on various intersections among the PA domains.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 740-746"},"PeriodicalIF":4.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of suicide in people living with dementia and comorbid mental health conditions: A systematic review and meta-analysis","authors":"Radvile Medeisyte ,&nbsp;Eleanor Nuzum ,&nbsp;Amber John ,&nbsp;Anastasia Tsipa ,&nbsp;Caroline Fearn ,&nbsp;Georgina Charlesworth ,&nbsp;Sebastian J. Crutch ,&nbsp;Céline El Baou ,&nbsp;Gavin R. Stewart ,&nbsp;Suman Kurana ,&nbsp;Emilie V. Brotherhood ,&nbsp;Katie Flanagan ,&nbsp;Alberto Salmoiraghi ,&nbsp;Amy Kerti ,&nbsp;Joshua Stott ,&nbsp;Roopal Desai","doi":"10.1016/j.jad.2025.03.075","DOIUrl":"10.1016/j.jad.2025.03.075","url":null,"abstract":"<div><h3>Background</h3><div>People with dementia (PwD) are more vulnerable to experiencing suicidal ideation than the general population. Within this group, certain risk factors such as being younger and male increase risk of death by suicide. However, currently little is known on whether comorbid mental health conditions in this population also elevate the risk of suicide outcomes. We aimed to determine if comorbid mental health conditions increased the risk of suicidal ideation, suicide attempts and death by suicide in PwD.</div></div><div><h3>Methods</h3><div>Five databases were searched from inception to July 2023. Peer-reviewed publications reporting data for suicide outcomes in PwD with a comorbid mental health condition were included. Random effects meta-analyses models were used to calculate the pooled effect sizes.</div></div><div><h3>Results</h3><div>22 relevant studies were identified for inclusion 14 of which reported sufficient data to be included in the meta-analyses. In PwD, those with a general psychiatric comorbidity were at increased risk of death by suicide (OR = 2.61, [95%CI: 1.47; 4.63]). Those with comorbid depression or anxiety were at increased risk of all suicide outcomes (depression: ideation OR = 5.11, [95%CI:1.73;15.07], attempt OR = 7.75, [95%CI:2.68;22.41], death OR = 3.44 [95%CI:1.65;7.18]; anxiety: ideation OR = 3.69, [95%CI:1.41;9.66]; attempt OR = 2.27, [95%CI:1.08;4.78]; death OR = 2.36, [95%CI:2.02;2.75]). PwD and comorbid personality disorder and substance use were at increased risk of suicide attempt (OR = 4.60, [95%CI:1.36;15.55] and death by suicide (OR = 2.19, [95%CI:1.80;2.66] respectively.</div></div><div><h3>Conclusion</h3><div>Comorbid mental health conditions put PwD at increased risk of suicide outcomes. There is an urgent need for the assessment and monitoring of mental health in PwD in routine care to mitigate suicide risk.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 835-844"},"PeriodicalIF":4.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in magnetic susceptibility correlate with higher cerebral blood flow in the right amygdala of patients with major depressive disorder","authors":"Qianyun Chen ,&nbsp;Zhifeng Zhou ,&nbsp;Hongyan Huang ,&nbsp;Yingli Zhang ,&nbsp;Gangqiang Hou ,&nbsp;Yingwei Qiu","doi":"10.1016/j.jad.2025.03.070","DOIUrl":"10.1016/j.jad.2025.03.070","url":null,"abstract":"<div><h3>Background</h3><div>The amygdala plays a crucial role in emotion processing and is a key target for understanding the mechanisms underlying major depressive disorder (MDD). This study aimed to investigate the magnetic susceptibility of the amygdala in MDD and examine its association with structural and cerebral blood flow (CBF) changes.</div></div><div><h3>Methods</h3><div>A total of 158 individuals were included in the study, comprising 86 patients with MDD and 72 healthy controls. Depression severity was assessed using Hamilton Depression Rating Scale. Quantitative susceptibility mapping (QSM), T1-weighted, and arterial spin labeling scans were conducted to measure amygdala magnetic susceptibility, volume, and CBF, respectively. Group differences were compared, and associations between susceptibility, volume, and CBF were examined.</div></div><div><h3>Results</h3><div>The median susceptibility of the amygdala was significantly higher in MDD patients than in controls (all <em>p</em> &lt; 0.01). In the MDD group, increased QSM value in the right amygdala was associated with higher CBF (<em>r</em> = 0.28, <em>p</em> = 0.01), whereas no significant correlation was found between QSM value and volume (<em>p</em> = 0.76). Increased QSM value in the right amygdala was associated with worse depressed mood (<em>r</em> = 0.30, <em>p</em> &lt; 0.01).</div></div><div><h3>Limitation</h3><div>Retrospective cross-sectional study conducted at a single center.</div></div><div><h3>Conclusion</h3><div>The magnetic susceptibility of the amygdala was higher in MDD patients with than in controls. QSM changes in the right amygdala correlated with increased CBF and worse depressed mood, indicating both microstructural and functional alterations. Our results encourage further use of the QSM technique in the elucidation of MDD pathophysiology.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 703-709"},"PeriodicalIF":4.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cardiovascular comorbidities and psychological anxiety & depression in the elderly","authors":"Yongcheng Ren ,&nbsp;Dongdong Qi ,&nbsp;Nan Sun ,&nbsp;Chang Yu ,&nbsp;Yantao Mu ,&nbsp;Xinjie Tian ,&nbsp;Jing Zhang ,&nbsp;Shuhui Wu ,&nbsp;Jing Luo ,&nbsp;Lei Yang ,&nbsp;Hao Chen","doi":"10.1016/j.jad.2025.03.071","DOIUrl":"10.1016/j.jad.2025.03.071","url":null,"abstract":"<div><h3>Background</h3><div>Limited research examining the relationship between cardiovascular comorbidities and psychological anxiety &amp; depression in the elderly, and the conclusions are inconsistent. This study aimed to investigate the intricate relationships between them among the pariticipants aged 60 years and above.</div></div><div><h3>Methods</h3><div>Utilizing multivariate logistic regression and stratified analysis to analyze the association between cardiovascular comorbidities and psychological anxiety &amp; depression. Trend analysis was performed to evaluate the risk of developing depression and anxiety as the number of diseases increased. Interaction analysis was utilized to explore potential factors underlying the comorbidity of cardiovascular diseases and depression.</div></div><div><h3>Results</h3><div>Among 11,960 elder participants (mean age 82 years, 46.5 % male), the prevalences of psychological anxiety, depression, and ≥2 types of cardiovascular diseases are 11.7 %, 25.8 %, and 24.7 %, respectively. Compared to subjects without cardiovascular diseases, those with 2, 3, and 4 types of cardiovascular diseases respectively have increased risk of depression, with corresponding ORs (95 % CI) being 1.23 (1.08–1.40), 1.50 (1.24–1.81), and 1.91 (1.42–2.56), respectively. Trend analysis shows that for each additional cardiovascular comorbidity, the risk of depression increases by 15 % (OR 1.15, 95%CI 1.10–1.20). The interaction effect showed that social activities were both additive and multiplicative factors affecting cardiovascular comorbidity and depression. The association between the risk of anxiety and the complexity of cardiovascular comorbidities is not strong (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>As the complexity of cardiovascular comorbidity increases, the risk of depression skyrockets among older adults, social activities may serve as a remedy.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 655-661"},"PeriodicalIF":4.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health problems and influencing factors of parent-child separated children: An umbrella review of meta-analysis","authors":"Xingda Ju ,&nbsp;Xinyu Li ,&nbsp;Qingcheng Guo ,&nbsp;Jing Li ,&nbsp;Chao Bi ,&nbsp;Bo Hu ,&nbsp;Chang Lu","doi":"10.1016/j.jad.2025.03.086","DOIUrl":"10.1016/j.jad.2025.03.086","url":null,"abstract":"<div><h3>Background</h3><div>An increasing number of parents are forced to part with their children due to the pressures of life or unpredictable circumstances. This forced separation often has a devastating effect on children's minds, leading to a range of mental health problems.</div></div><div><h3>Methods</h3><div>We searched five databases (EBSCO, PubMed, Scopus, Web of Science, and China National Knowledge Infrastructure) from inception to November 17, 2023, and performed a systematic analysis using Comprehensive Meta-Analysis (CMA) 3.0.</div></div><div><h3>Results</h3><div>We identified 28 eligible meta-analyses with 746,175 participants across 170 outcomes. Parent-child separated (PcS) children were at higher risk for emotional problems (d = 0.22 [95 % CI 0.17–0.28]), cognitive problems (d = 0.20 [95 % CI 0.10–0.29]), behavioral problems (d = 0.21 [95 % CI 0.15–0.27]) and psychosis (d = 0.22 [95 % CI 0.15–0.29]) than non-PcS children. Regarding influencing factors, both personal and social factors were moderately positively correlated with emotional and behavioral problems. Family factors had a moderate positive correlation between emotional problems (z = 0.20, [95CI% 0.12–0.28]), and a low positive correlation with behavioral problems (z = 0.13, [95CI% 0.04–0. 22]). After addressing the issue of overlapping data, there were no significant differences in emotional problems in children with PcS compared to non-PcS children.</div></div><div><h3>Limitations</h3><div>The majority of studies included in our umbrella review were from China, which may limit the generalizability of our findings.</div></div><div><h3>Conclusion</h3><div>PcS children suffer more mental health problems than non-PcS children. The community needs to act and intervene proactively to promote the improvement of the mental health of these children.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 481-488"},"PeriodicalIF":4.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma and anxiety interactions relate to reward processing in adolescents","authors":"Alexa N. Duran ,&nbsp;Ruiyu Yang ,&nbsp;Madelin Gredvig ,&nbsp;Jillian Lee Wiggins","doi":"10.1016/j.jad.2025.03.076","DOIUrl":"10.1016/j.jad.2025.03.076","url":null,"abstract":"<div><div>Anxiety is highly prevalent among adolescents, often linked to trauma exposure. However, not all youth with trauma develop anxiety, suggesting variability in risk pathways. This study investigates how neural reward system alterations may signal vulnerability to anxiety following trauma. We hypothesized that differences in reward-related connectivity in the ventral striatum and amygdala would distinguish adolescents with higher trauma and higher anxiety (anxiety risk group) from those with higher trauma but lower anxiety (non-anxiety development), as well as from youth with lower trauma and lower anxiety (typical development) and with lower trauma and higher anxiety (non-trauma-related anxiety). We utilized a sample of 44 adolescents (ages 11–19) with varying levels of trauma exposure and anxiety who completed a child-friendly monetary incentive delay task and analyzed their amygdala and ventral striatum functional connectivity during the task to assess the interaction between trauma exposure and anxiety levels. Our findings reveal distinct Trauma x Anxiety neural connectivity patterns in widespread prefrontal, temporal, and occipital clusters, potentially serving as biomarkers for anxiety risk. These results provide insight into potential neurobiological markers associated with anxiety vulnerability, bringing us a step closer to identifying targets for future intervention development. By highlighting unique patterns of reward processing associated with different trauma and anxiety profiles, this study advances our knowledge of the neural mechanisms underlying anxiety risk, laying the groundwork for future research on neurobiologically informed approaches to prevention and treatment.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 662-672"},"PeriodicalIF":4.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related changes in depression symptom networks in children in China with parental absence: A comparative analysis of youth aged nine to 18","authors":"Qian-Nan Ruan ,&nbsp;Cheng-Han Li ,&nbsp;Su Xu ,&nbsp;Wen-Jing Yan","doi":"10.1016/j.jad.2025.03.082","DOIUrl":"10.1016/j.jad.2025.03.082","url":null,"abstract":"<div><h3>Background</h3><div>The network perspective on psychopathology views depression as a system of interacting symptoms. Research shows that mental health problems change with age. Children with parental absence are at risk for depression, but it's unclear how their depressive symptom networks evolve across developmental stages.</div></div><div><h3>Method</h3><div>Network analysis was conducted on data from 179,519 children with parental absence who completed the depression scale CES<img>D. The Graphical LASSO algorithm was used to construct depressive symptom networks for each age group. Global network metrics and centrality measures were then calculated and compared across age groups.</div></div><div><h3>Results</h3><div>Depressive symptoms increased with age, with mean CES-D scores rising from 3.44 at age nine to 10.8 at age 17. Network density showed a general increase from age nine (0.045) to age 17 (0.047), while average path length decreased from age nine (18.380) to age 18 (15.338) and clustering coefficient decreased from age 9 (0.879) to age 18 (0.706). Closeness centrality demonstrated the most substantial age-related effect (F = 1445.111, <em>p</em> &lt; 0.001, η² = 0.225), with significant increases from early to late adolescence. Core emotional symptoms remained central across ages, while loneliness and feelings of failure became more central with age.</div></div><div><h3>Conclusion</h3><div>As children with parental absence age, their depressive symptom networks become more severe, interconnected, and efficiently structured. This suggests a need for age-specific interventions addressing both core symptoms and emerging adolescent self-evaluative concerns, advancing our understanding of developmental psychopathology in this vulnerable group.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 730-739"},"PeriodicalIF":4.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique relations of avoidant, emotion, and problem focused coping and suicidality in a sample of sexual and gender minorities","authors":"Bryce K. Clausen ,&nbsp;Daniela Porro ,&nbsp;Michael J. Zvolensky ,&nbsp;Daniel W. Capron ,&nbsp;Victor Buitron ,&nbsp;Brian J. Albanese","doi":"10.1016/j.jad.2025.03.077","DOIUrl":"10.1016/j.jad.2025.03.077","url":null,"abstract":"<div><div>Individuals who identify as a sexual or gender minority experience health related disparities in suicidal ideation, behavior, and attempts. Although past research has demonstrated that specific stressors may be unique to sexual or gender minorities contributing to suicidal ideation (e.g., minority stress), little work has been dedicated to understanding the role specific coping styles play in their associations with suicidal ideation among individuals who identify as a sexual or gender minority. The present study sought to address this gap in research and evaluate the unique associations of avoidant, emotional, and problem focused coping on suicidal ideation after accounting for theoretically relevant covariates. Participants included 372 individuals who identified as either a sexual or gender minority (<em>M</em>_<em>age</em> = 20.76, 83.3 % identified as female, 47.8 % White or Caucasian, 16.1 % Southeast Asian, 7.8 % Black or African American, 7.8 % multi-racial, 7 % other, 4.6 % East Asian, 2.7 % American Indian/ Alaska Native, 0.5 % Native Hawaiian or Other Pacific Islander). Results indicated that avoidant and emotional coping were associated with severity in suicidal ideation and suicidal cognitions, but avoidant coping was the only coping style that statistically significantly predicted greater likelihood of non-zero suicidal ideation/ cognition endorsement. Moreover, problem focused coping was the only style associated with less severe suicidal ideation and cognition. Overall, the present findings are the first to demonstrate unique associations of coping styles with suicidal ideation in the context of individuals who identify as a sexual or gender minority.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 473-480"},"PeriodicalIF":4.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acid reflux medication use among adults with depressive symptoms","authors":"Shakila Meshkat ,&nbsp;Qiaowei Lin ,&nbsp;Vanessa K. Tassone ,&nbsp;Reinhard Janssen-Aguilar ,&nbsp;Hilary YM Pang ,&nbsp;Wendy Lou ,&nbsp;Venkat Bhat","doi":"10.1016/j.jad.2025.03.085","DOIUrl":"10.1016/j.jad.2025.03.085","url":null,"abstract":"<div><div>Emotional stress, including depression, may contribute to increased gastroesophageal reflux disease symptoms. In this paper, we aim to evaluate the associations between depressive symptoms, depressive symptom severity, and symptom clusters with acid reflux medication use, considering the potential interaction effect of sex. Data from the 2007–2018 National Health and Nutrition Examination Survey were used. Participants aged 18 years or older were included if they responded to the depressive symptoms and prescription medication questionnaires. This study included 31,444 participants, of whom 2871 had depressive symptoms. Participants with depressive symptoms had significantly higher odds of using antacids (aOR = 1.735; <em>p</em> &lt; 0.001), histamine-2 receptor antagonists (H2RAs) (aOR = 1.653; p &lt; 0.001), and proton pump inhibitors (PPIs) (aOR = 1.723; <em>p</em> &lt; 0.001). A positive association was also found between depressive symptom severity and the use of antacids (aOR = 1.054; <em>p</em> &lt; 0.001), H2RAs (aOR = 1.048; p &lt; 0.001), and PPIs (aOR = 1.053; <em>p</em> &lt; 0.001). Moreover, increases in cognitive-affective and somatic scores were associated with higher odds of using antacids (aOR = 1.080 for cognitive, 1.102 for somatic; <em>p</em> &lt; 0.001), H2RAs (aOR = 1.078 for cognitive, 1.083 for somatic; p &lt; 0.001), and PPIs (aOR = 1.075 for cognitive, 1.105 for somatic; p &lt; 0.001). No significant sex interaction effects were observed. Adjusted models demonstrated no significant associations between depressive symptoms and the duration of medication use. This study provides evidence of an association between depressive symptoms and acid reflux medication use, highlighting the need to screen for related symptoms in patients with depressive symptoms.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 747-754"},"PeriodicalIF":4.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}