Journal of affective disorders最新文献

{"title":"From obesity to mind: Enhancing the understanding of depression outcomes in the NHANES.","authors":"Tong Feng, QingYuan Li, Ran Duan","doi":"10.1016/j.jad.2025.120051","DOIUrl":"10.1016/j.jad.2025.120051","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120051"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neutrophil percentage-to-albumin ratio mediates the association between depression and all-cause mortality in U.S. adults: Evidence from NHANES 2009-2018.","authors":"Kunxiu Wang, Gaofeng Liu, Yuchen Pan, Siyu Li, Xiaoling Zhu, Hui Qu, Xuesong Liang, Song Chen, Wenbin Fu","doi":"10.1016/j.jad.2025.119736","DOIUrl":"10.1016/j.jad.2025.119736","url":null,"abstract":"<p><strong>Background: </strong>Depression significaantly reduces the quality of life for hundreds of millions of people globally. Evidence suggests associations among depression, the neutrophil percentage-to-albumin ratio (NPAR), and all-cause mortality (ACM). However, the interrelationship was not elucidated. This study aimed to unveil whether NPAR mediates the correlation between depression and ACM.</p><p><strong>Methods: </strong>A cross-sectional study was carried out based on data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018. ACM data were collected up to December 31, 2019. Weighted binary logistic regression and generalized linear regression models were leveraged to unravel pairwise associations among depression scores, NPAR, and ACM. Mediation analysis was performed to evaluate the potential mediating effects of NPAR on the relationship between depression and ACM.</p><p><strong>Results: </strong>18,709 participants were encompassed. In the fully adjusted model, depression scores (OR [95 % CI]: 1.035 [1.012, 1.058]) and NPAR (OR [95 % CI]: 1.15 [1.108, 1.194]) were significantly positively linked to ACM. Depression scores were positively correlated with NPAR (β [95 % CI]: 0.014 [0.001, 0.026]). NPAR mediated 5.27 % of the total association between depression and ACM. Subgroup analyses revealed that the mediating effect of NPAR was more prominent in specific populations.</p><p><strong>Conclusion: </strong>Among U.S. adults, depression significantly increases the risk of ACM, and this relationship is mediated by NPAR. The mediating effect of NPAR varied by sex, age, race, and health status. These findings fill gaps in the existing literature.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119736"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between wearable device-measured weekend catch-up sleep and brain health in UK Biobank participants.","authors":"Yanxu Zheng, Jing Bao, Tingpei Hu, Jin Wang, Jingyu Liu, Haozhe Chang, Ying He, Shuhang Huang, Zhaowei Zhu, Jinze Wu","doi":"10.1016/j.jad.2025.119779","DOIUrl":"10.1016/j.jad.2025.119779","url":null,"abstract":"<p><p>This study explores whether weekend catch-up sleep (WCS) influences the risk of major neurological and psychiatric disorders-including depression, anxiety, dementia, stroke, and Parkinson's disease (PD)-in a cohort of 91,665 participants from the UK Biobank, tracked over an average of 7.98 years. Accelerometer-measured sleep data were used to categorize WCS duration into four groups: no WCS (≤0 h), short (>0 to <1 h), medium (≥1 to <2 h), and long (≥2 h). Using Cox proportional hazards models that controlled for various confounding factors, along with restricted cubic spline analyses to examine potential nonlinear relationships, the results indicated that both medium (HR 0.82, 95 % CI: 0.72-0.92) and short (HR 0.85, 95 % CI 0.77-0.95) WCS were associated with reduced depression risk, with medium WCS also linked to lower anxiety risk (HR 0.88, 95 % CI: 0.78-0.99). These associations exhibited clear nonlinear patterns (p for nonlinearity < 0.001). However, no significant relationship was found between WCS and dementia, stroke, or PD risk. Overall, these findings highlight medium-duration WCS as a potentially beneficial practice for improving mental health outcomes-specifically, by reducing depression and anxiety risks. Nevertheless, the impact on other neurological conditions remains uncertain. Future research should verify these associations across diverse populations and further explore underlying biological mechanisms.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"119779"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of 'weekend warrior' physical activity pattern and depressive symptoms.","authors":"Eduardo Rossato de Victo, Rafael Mathias Pitta, Gerson Ferrari, Felipe Barreto Schuch, Luana de Lima Queiroga, Oskar Kaufmann, Nelson Wolosker","doi":"10.1016/j.jad.2025.119911","DOIUrl":"10.1016/j.jad.2025.119911","url":null,"abstract":"<p><strong>Background: </strong>Physical activity (PA) is recognized as a protective factor against depressive symptoms; however, the role of different PA patterns remains unclear. This study aimed to investigate the association between the \"weekend warrior\" PA pattern and depressive symptoms in the Brazilian population, with analyses stratified by sex and obesity status.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 29,907 individuals aged 18 and older who underwent screening exams between 2008 and 2022 at a Brazilian hospital. PA was assessed using the long form of the International Physical Activity Questionnaire. Participants were grouped into three PA patterns: Not meeting PA recommendation (<150 min/week of moderate-to-vigorous PA), weekend warrior (≥150 min/week concentrated on 1-2 days), and regularly active (≥150 min/week on ≥3 days). Depressive symptoms were defined as a Beck Depression Inventory-II score ≥ 14. Logistic regression tested the associations in an unadjusted model and three adjusted models, controlling for sociodemographic, behavioral, and clinical variables.</p><p><strong>Results: </strong>The prevalence of depressive symptoms among participants was 10.4 %. The weekend warrior PA pattern was not associated with depressive symptoms. The regularly active PA pattern was associated with a lower likelihood of depressive symptoms (OR: 0.56; 95%CI: 0.52-0.61), and this association remained significant after adjustment across different models (OR: 0.68; 95%CI: 0.62-0.75). In the stratified analyses, no association was found between the weekend warrior PA pattern and depressive symptoms.</p><p><strong>Conclusion: </strong>The weekend warrior PA pattern was not associated with depressive symptoms, while the regularly active pattern was associated with lower odds, regardless of sex or obesity status.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119911"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study on the relationship between cardiorespiratory fitness, inhibitory control, and event-related potentials moderated by severity of symptoms in patients with major depressive disorder.","authors":"Nils H Pixa, Stephanie Fröhlich, Tim Göcking, Lothar Thorwesten, Sarah E Fromme, Bernhard T Baune, Claudia Voelcker-Rehage","doi":"10.1016/j.jad.2025.119701","DOIUrl":"10.1016/j.jad.2025.119701","url":null,"abstract":"<p><strong>Background: </strong>Depression affects around 280 million people globally, with a lifetime prevalence of 20% for Major Depressive Disorder (MDD). Core MDD symptoms are impaired executive functions (EF), such as inhibitory cognitive control. Higher cardiorespiratory fitness (CRF) is linked to improved cognitive function, but whether this also applies to MDD patients remains unclear.</p><p><strong>Methods: </strong>This study examined the relationship between CRF and inhibitory control in 66 MDD patients (33 females, aged 18-63). Participants underwent VO2max testing after completing a flanker task while event-related potentials (ERPs) (N1, N2, P3) were assessed. Hierarchical multiple linear regressions were used to analyze the influence of CRF on flanker performance and ERP components, controlling for MDD severity, negative affect, and demographic variables.</p><p><strong>Results: </strong>CRF explained 15% of the variance in flanker performance (∆R² = 0.15, p < .001), with the final model (including all variables) explaining 47 %. This positive effect of CRF was independent of MDD severity. Concerning the ERP correlates, CRF showed a medium effect on N1 latency at O1 (β = -0.32, p = .04, ∆R² = 0.07, p = .04) with shorter latency in fitter individuals.</p><p><strong>Limitations: </strong>The study's cross-sectional design and moderate sample size limits causal inference.</p><p><strong>Conclusions: </strong>CRF was positively related to inhibitory cognitive control in MDD patients, independent of symptom severity, suggesting cognitive benefits. Earlier N1-peaks in fitter individuals suggest potential higher neural efficiency. Limited associations with ERP components indicate complex neural mechanisms, warranting further research. MDD treatments integrating physical exercise could contribute to improving cognitive health and mitigate decline.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119701"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-pregnancy maternal metabolite signatures, genetic predisposition, and perinatal depressive symptom trajectories: A prospective birth cohort study.","authors":"Na Zhang, Xinyu Liu, Hui Wang, Wen Jiang, Xiaojing Zeng, Xiaoqing He, Qi Li, Xiaolin Wang, Yaorui Ye, Qianlong Zhang, Guowang Xu, Jun Zhang","doi":"10.1016/j.jad.2025.119768","DOIUrl":"10.1016/j.jad.2025.119768","url":null,"abstract":"<p><strong>Objective: </strong>To identify early-pregnancy maternal circulating metabolites linked to perinatal depressive symptom trajectories, and to assess the potential role of genetic predisposition in these associations.</p><p><strong>Methods: </strong>We included 990 pregnant women from the Shanghai Birth Cohort, enrolled during early pregnancy. Maternal depressive symptoms were assessed during mid-pregnancy and at 42 days and 6 months postpartum using the Center for Epidemiologic Studies Depression Scale and Edinburgh Postnatal Depression Scale. A liquid chromatography-mass spectrometry metabolomics approach was employed to profile maternal serum metabolites. Perinatal depressive symptom trajectories were determined through group-based trajectory modelling, and metabolites were identified using elastic net and multinomial logistic regression.</p><p><strong>Results: </strong>Five perinatal depressive symptom trajectories were established: no symptoms (52.1 %, n = 516), low-stable (29.4 %, n = 291), resilient (10.9 %, n = 108), and recurrent (4.0 %, n = 40), and emergent (3.5 %, n = 35). Each unit increase in natural log-transformed FA 24: 0 (odds ratio (OR): 1.26, 95 % confidence interval (CI): 1.07-1.48) and 16,17-didehydropregnenolone (OR: 1.35, 95 % CI: 1.16-1.58) was associated with an elevated risk of a low-stable trajectory, while 16,17-didehydropregnenolone also linked to a higher risk of the recurrent trajectory (OR: 1.73, 95 % CI: 1.22-2.47). Conversely, metabolites such as 3beta,7alpha-Dihydroxy-5-cholestenoate and FA 6:0 were correlated with a reduced risk. No significant interactions were found between the identified metabolites and polygenetic risk.</p><p><strong>Conclusions: </strong>Early-pregnancy maternal metabolites were associated with perinatal depressive symptom trajectories, independent of genetic predisposition. These findings underscore the potential role of metabolic biomarkers in predicting perinatal depression. Future studies are warranted to replicate these findings in diverse cohorts and explore causality.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119768"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital technology empowers family education to improve adolescent mental health and reduce suicide tendency.","authors":"Xinqiao Liu, Ao Shen","doi":"10.1016/j.jad.2025.119780","DOIUrl":"10.1016/j.jad.2025.119780","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119780"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of delivery format on the effectiveness and acceptability of self-guided interventions for depression in older adults: A systematic review and meta-analysis.","authors":"Dara Kiu Yi Leung, Dipsy Ho Sum Wong, Frankie Ho Chun Wong, Stephanie Ming Yin Wong, Oscar Long Hung Chan, Gloria Hoi Yan Wong, Wai Chi Chan, Terry Yat Sang Lum","doi":"10.1016/j.jad.2025.119756","DOIUrl":"10.1016/j.jad.2025.119756","url":null,"abstract":"<p><p>Self-guided interventions could improve the availability of evidence-based psychotherapies for late-life depressive symptoms. However, their treatment outcomes and acceptability across delivery formats remain uncertain. This review aimed to examine the effectiveness and acceptability of self-guided intervention for older adults with depressive symptoms and the impact of different intervention features. Randomised controlled trials included older adults (mean age ≥ 60 years) with elevated depressive symptoms who received self-guided interventions for depression were eligible. Trials were extracted from an existing database and updated systematic literature searches in PubMed, PsychINFO, Embase, and Cochrane Library (last update: 20th Mar 2025). Data were synthesised with random-effects meta-analysis, subgroup analysis, and meta-regressions. Outcomes included depressive symptoms, quality of life, and dropout rates. Seven studies with 1170 participants were identified. Compared to controls, self-guided interventions had small-to-moderate effect in reducing depressive symptoms at post-treatment (g = 0.46, 95 % CI 0.20 to 0.73), but the effect was not sustained at 3-to-12-month follow-up (g = 0.15, 95 % CI -0.45 to 0.74). Effects on quality of life remains inconclusive. Acceptability was comparable between self-guided interventions and control conditions (RR = 1.52, p = .294). No differences in treatment effects and acceptability were observed across delivery formats, support levels, or initial human screening. Most studies showed a moderate-to-high risk of bias (n = 6). Self-guided interventions for depression were associated with reductions in depressive symptoms and were acceptable to older adults, regardless of delivery format and level of human support. They may be considered a brief intervention option in resource-limited setting.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119756"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exercise on mental health in mice with circadian rhythm disruption.","authors":"Chunxiao He, Masahiro Wakayama, Hanlin Jiang, Tingrui Zhao, Yifan Zhang, Bin Liu, Hideki Moriyama","doi":"10.1016/j.jad.2025.119936","DOIUrl":"10.1016/j.jad.2025.119936","url":null,"abstract":"<p><strong>Background: </strong>Circadian rhythm disruptions are major contributors to anxiety and depression, potentially involving mechanisms like altered clock gene activity and midbrain dopamine system impairments. Exercise has been shown to play a significant role in maintaining the stability of the circadian rhythm and promoting mental health. This study aimed to investigate whether various exercise modes could alleviate mental health issues triggered by circadian rhythm disruption.</p><p><strong>Methods: </strong>A total of 48 male C57BL/6J mice were randomly divided into four groups: control group, circadian rhythm disruption group, aerobic exercise group with circadian rhythm disruption, and resistance exercise group with circadian rhythm disruption. Circadian rhythm disruption was induced by altering the light-dark cycle every three days, followed by four weeks of exercise intervention. The behavioral rhythms of mice were evaluated through sleep recording. Behavioral assessments, including the open field test, elevated plus maze, and forced swim test, were used to evaluate anxiety- and depression-like behaviors. The expression of clock genes and dopamine levels in the prefrontal cortex were analyzed using quantitative real-time PCR and enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Exercise interventions significantly reduced anxiety- and depression-like behaviors in the mice. Aerobic and resistance exercise significantly maintained the circadian rhythmic expression pattern of the Bmal1 gene. Aerobic exercise increased dopamine levels in the prefrontal cortex.</p><p><strong>Conclusion: </strong>Exercise, especially aerobic exercise, effectively alleviates mental health challenges associated with circadian rhythm disruption by influencing clock gene expression and dopamine regulation in the prefrontal cortex. These findings provide evidence for the potential use of exercise interventions as therapeutic strategies for circadian rhythm-related mental health problems.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119936"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does intimate partner violence mediate the association between adverse childhood experiences and internalizing symptomatology in women? A mediation meta-analysis.","authors":"Julia Martini, Audrey-Ann Deneault, Jenney Zhu, Nicole Racine, Pasco Fearon, Sheri Madigan, Jennifer M Jenkins","doi":"10.1016/j.jad.2025.119742","DOIUrl":"10.1016/j.jad.2025.119742","url":null,"abstract":"<p><p>Research is needed to elucidate the underlying mechanisms that link adverse childhood experiences (ACEs) and internalizing symptomatology in women. In the present study, we conducted a systematic review to assess whether intimate partner violence (IPV) mediated the association between ACEs and internalizing symptomatology in women. We utilized a novel statistical technique-meta-analytic structural equation modelling (MASEM)-to examine the path model by amalgamating effect sizes across all studies, thereby combining both meta-analytic and structural equation modelling approaches. A total of 25 studies (N = 30,737 women) were included in the MASEM. The average age of female participants was 30.4 years. Results indicated that IPV partially mediated the association between ACEs and internalizing symptomatology, explaining 16 % of the total effect. Tested moderators included sociodemographic factors (age, SES, single status, and minority status) and methodological factors, including IPV characteristics (IPV category and IPV timeline), psychopathology assessment method, and the number of ACEs items measured. None of the tested moderators significantly influenced the indirect pathway. Findings suggest that IPV is an important risk factor in explaining why ACEs are associated with internalizing symptomatology in women.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119742"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}