Journal of affective disorders最新文献

{"title":"Modifiable lifestyle factors influencing neurological and psychiatric disorders mediated by structural brain reserve: An observational and Mendelian randomization study.","authors":"Yiran Dong, Pan Zhang, Jinghui Zhong, Jinjing Wang, Yingjie Xu, Hongmei Huang, Xinfeng Liu, Wen Sun","doi":"10.1016/j.jad.2024.12.038","DOIUrl":"10.1016/j.jad.2024.12.038","url":null,"abstract":"<p><strong>Background: </strong>Modifiable lifestyle factors are implicated as risk factors for neurological and psychiatric disorders, but whether these associations are causal remains uncertain. We aimed to evaluate associations and ascertain causal relationships between modifiable lifestyle factors, neurological and psychiatric disorder risk, and brain structural magnetic resonance imaging (MRI) markers.</p><p><strong>Methods: </strong>We analyzed data from over 50,000 UK Biobank participants with self-reported lifestyle factors, including alcohol consumption, smoking, physical activity, diet, sleep, electronic device use, and sexual factors. Primary outcomes were stroke, all-cause dementia, Parkinson's disease (PD), Major depression disorder (MDD), Anxiety Disorders (ANX), and Bipolar Disorder (BIP), alongside MRI markers. Summary statistics were obtained from genome-wide association studies and Mendelian randomization (MR) analyses investigated bidirectional associations between lifestyle factors, neurological/psychiatric disorders, and MRI markers, with mediation assessed using multivariable Mendelian randomization (MVMR).</p><p><strong>Results: </strong>Cross-sectional analyses identified lifestyle factors were associated with neurological and psychiatric disorders and brain morphology. MR confirmed causal relationships, including lifetime smoking index on Stroke, PD, MDD, ANX and BIP; play computer games on BIP; leisure screen time on Stroke and MDD; automobile speeding propensity on MDD; sexual factors on MDD and BIP; sleep characteristics on BIP and MDD. Brain structure mediated several lifestyle-disorder associations, such as daytime dozing and dementia, lifetime smoking and PD and age first had sexual intercourse and PD.</p><p><strong>Conclusion: </strong>Our results provide support for a causal effect of multiple lifestyle measures on the risk of neurological and psychiatric disorders, with brain structural morphology serving as a potential biological mediator in their associations.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"440-450"},"PeriodicalIF":4.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal dynamics between the central nodes in the symptoms network of borderline personality disorder: An intraindividual network analysis.","authors":"Said Jiménez, Iván Arango de Montis, Eduardo A Garza-Villarreal","doi":"10.1016/j.jad.2024.12.005","DOIUrl":"10.1016/j.jad.2024.12.005","url":null,"abstract":"<p><strong>Background: </strong>Borderline Personality Disorder (BPD) is a severe and heterogeneous psychiatric condition. Current research has some limitations: (1) findings from group (i.e., interindividual) analyses are often incorrectly generalized to individuals (i.e., intraindividual); and (2) research tends to emphasize common causes of symptomatology rather than exploring the interrelationships between symptoms.</p><p><strong>Method: </strong>The current study aimed to analyze the intraindividual dynamics of central BPD symptoms using a temporal network analysis. Longitudinal measurement data collected over two years at regular six-month intervals in 212 patients diagnosed with BPD were used.</p><p><strong>Results: </strong>The network analysis extracted temporal and contemporaneous intraindividual relationships, the former were directional relationships between previous emptiness and subsequent identity instability, as well as identity instability and anger dysregulation. Also, previous anger dysregulation predicted identity instability and subsequent emptiness. In the same time window, the contemporaneous network and its topology underscored the relevance of anger dysregulation for its relation to most BPD symptoms, including identity instability and suicidal intent.</p><p><strong>Limitation: </strong>Measurements with widely spaced intervals do not capture symptom dynamics in a recording window similar to real-time.</p><p><strong>Conclusion: </strong>Exploring the dynamic between anger dysregulation and identity instability may be crucial for understanding the severity of BPD at the individual level and could potentially inform treatment.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"431-439"},"PeriodicalIF":4.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between skeletal muscle mass to visceral fat area ratio and depression: A cross-sectional study based on the National Health and Nutrition Examination Survey.","authors":"Chenle Ye, Guangzhan Chen, Weikai Huang, Yuanrun Liu","doi":"10.1016/j.jad.2024.12.041","DOIUrl":"10.1016/j.jad.2024.12.041","url":null,"abstract":"<p><strong>Background: </strong>Skeletal muscle mass to visceral fat area ratio (SVR) has emerged as a key indicator for evaluating sarcopenic obesity (SO). The study aimed to elucidate the association between SVR and depression among US adults.</p><p><strong>Methods: </strong>Utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018, this cross-sectional study employed weighted multivariable logistic regression and restricted cubic splines (RCS) to explore the association between SVR and depression. Subgroup and interaction analyses were also performed.</p><p><strong>Results: </strong>The analysis encompassed 7,262 US adults. In the fully adjusted model, a significant negative association between SVR and depression was observed (OR = 0.35, 95%CI: 0.14-0.87). Additionally, SVR was significantly negatively correlated with mild (OR = 0.53, 95 % CI: 0.30-0.96) and severe depression (OR = 0.19, 95 % CI: 0.05-0.84). When SVR was stratified into quartile (Q1-Q4), individuals in the highest quartile exhibited a lower likelihood of depression compared to those in the lowest quartile (OR = 0.65, 95 % CI: 0.42-0.99). Additionally, the third quartile of SVR was significantly negatively associated with mild depression (OR = 0.72, 95 % CI: 0.53-0.98). No significant non-linear dose-response relationship between SVR and depression prevalence was detected (P-nonlinear = 0.3387). The association remained significant in several subgroup analyses. However, the interaction test revealed that none of the stratified variables were significant (all P for interaction > 0.05).</p><p><strong>Conclusion: </strong>The study was pioneering in establishing a negative association between SVR and depression within the US population.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"314-323"},"PeriodicalIF":4.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking 24-hour movement behaviour guidelines to core symptoms and school engagement of youth with moderate/severe ADHD.","authors":"Jinming Li, Yanxia Chen, Fabian Herold, Nicole E Logan, Denver M Y Brown, Justin A Haegele, Zhihao Zhang, Alyx Taylor, Sima Dastamooz, Markus Geber, Arthur F Kramer, Neville Owen, Yanping Gao, Liye Zou","doi":"10.1016/j.jad.2024.12.039","DOIUrl":"10.1016/j.jad.2024.12.039","url":null,"abstract":"<p><strong>Background: </strong>The independent associations of physical activity (PA), sleep duration (SL), and screen time (ST) with health outcome measures have been well-documented among children and adolescents, but not in youth with moderate/severe ADHD. To this end, the present study aimed to investigate the associations between three components within 24-hour movement behaviour (24-HMB) framework and core symptoms and school engagement in youth with moderate/severe ADHD.</p><p><strong>Methods: </strong>This study used pooled data from the 2021-2022 U.S. National Survey of Children's Health, which included a nationally representative sample of 4797 youth aged 6-17 years. Logistic/Ordinal regressions examined associations between meeting 24-HMB guideline combinations and core symptoms and school engagement among youth with moderate/severe ADHD, adjusting for age, sex, family income, body mass index, and ethnicity.</p><p><strong>Results: </strong>Only 6.9% of youth with moderate/severe ADHD met all three 24-HMB guidelines. Compared to those meeting no guidelines, youth meeting all guidelines was beneficially associated with inattention symptoms (self-regulation: OR=0.44, 95%CI: 0.35-0.57; concentration: OR= 1.26, 95%CI: 1.01-1.55) and better performance of school engagement (caring about doing well: OR = 0.52, 95%CI: 0.41-0.65; completing homework: OR = 0.49, 95%CI: 0.39-0.62). Meeting the ST + SL guidelines was associated with significantly lower odds of hyperactivity/impulsivity symptoms (argument, OR = 1.33, 95% CI: 1.12-1.58; staying calm, OR = 0.59, 95% CI: 0.46-0.75) compared to those who met none of guidelines.</p><p><strong>Conclusions: </strong>Meeting 24-HMB guidelines was associated with lower likelihood of ADHD core symptoms and greater likelihood of school engagement. Integrative \"whole day\" behavioural interventions warrant consideration for improving school engagement-related outcomes and reducing ADHD core symptoms in this vulnerable population.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"422-430"},"PeriodicalIF":4.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental variables influence the relationship between maternal depressive symptoms and toddlers' neurocognitive and affective outcomes.","authors":"M Viragova, S Falconer, A Chew, A D Edwards, P Dazzan, C Nosarti","doi":"10.1016/j.jad.2024.12.035","DOIUrl":"10.1016/j.jad.2024.12.035","url":null,"abstract":"<p><p>Motherhood is often associated with joy, but it can pose significant challenges, and in some instances lead to perinatal mental health problems. Maternal depressive symptoms can hinder a mother's ability to attune to her infant's needs, potentially affecting caregiving quality and emotional support. This study examines how parenting style and a cognitively stimulating home environment (i.e., individual level) and relative social deprivation (i.e., area level) contribute to the relationship between maternal depressive symptoms and offspring's neurocognitive and affective outcomes at 18 months. Participants were 479 mothers and children recruited as part of the Developing Human Connectome Project. Maternal postnatal depressive symptoms were assessed at term with the Edinburgh Postnatal Depression Scale. At a median corrected age of 18.4 months (range 17.3-24.3) children's outcomes were evaluated with the Bayley Scales of Infant and Toddler Development, Third Edition, the parent-rated Child Behaviour Checklist 1½ - 5 and the Early Childhood Behaviour Questionnaire. The Parenting Scale measured dysfunctional parenting in discipline situations; the Cognitively Stimulating Parenting Scale assessed experiences promoting cognitive stimulation in the home. Family socioeconomic status was evaluated using the Index of Multiple Deprivation. Toddler's outcomes were summarised into latent dimensions labelled 'neurocognitive' and 'affective'. Results from bootstrapped-based mediation analysis showed that a permissive parenting style and a less cognitively stimulating home environment modified the relationship between depressive symptoms and toddlers' neurocognitive outcomes. However, other factors, such as relative social deprivation and parental over-reactivity, did not alter this. Results also showed that an over-reactive parenting style modified the relationship between maternal depressive symptoms and toddlers' reduced capacity for effective emotional regulation, while relative social deprivation, permissive parenting and a cognitively stimulating home environment did not. These findings highlight the importance of understanding how environmental factors interact with parenting styles, and influence child development. The study emphasizes the need for interventions that create stable and supportive environments, mitigating the impact of suboptimal parenting on children's developmental outcomes.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"512-522"},"PeriodicalIF":4.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heritability, phenotypic, and genetic correlations across dimensional and categorical models of bipolar disorder in a family sample.","authors":"Alejandro Arbona-Lampaya, Heejong Sung, Alexander D'Amico, Emma E M Knowles, Emily K Besançon, Ally Freifeld, Ley Lacbawan, Fabiana Lopes, Layla Kassem, Antonio E Nardi, Francis J McMahon","doi":"10.1016/j.jad.2024.12.030","DOIUrl":"10.1016/j.jad.2024.12.030","url":null,"abstract":"<p><strong>Background: </strong>Bipolar disorder (BD) presents with a wide range of symptoms that vary among relatives, casting doubt on categorical illness models. To address this uncertainty, we investigated the heritability and genetic relationships between categorical and dimensional models of BD in a family sample.</p><p><strong>Methods: </strong>This retrospective study included participants (n = 397 Females, n = 329 Males, mean age 47 yr) in the Amish-Mennonite Bipolar Genetics (AMBiGen) study from North and South America that were assigned categorical mood disorder diagnoses (\"narrow\" or \"broad\") by structured psychiatric interview and completed the Mood Disorder Questionnaire (MDQ), which assesses lifetime history of manic symptoms and associated impairment. MDQ-dimensions were analyzed by Principal Component Analysis (PCA). Heritability and genetic overlaps between categorical diagnoses and MDQ-dimensions were estimated with SOLAR-ECLIPSE within 432 genotyped participants.</p><p><strong>Results: </strong>Individuals diagnosed with BD (n = 124) endorsed more MDQ items (61 %) than those with other mood disorders (26 %) or with no mood disorder (9 %), as expected. PCA suggested a three-component model for the MDQ, capturing 60 % of the variance. Heritability of the MDQ and its principal components was significant but modest (20-30 %, p < 0.001). Genetic correlations between MDQ measures and categorical diagnoses (ρG = 0.62-1.0; p < 0.001) were stronger than phenotypic correlations (ρP = 0.11-0.58; p < 0.001).</p><p><strong>Limitations: </strong>Recruitment through probands with BD resulted in increased prevalence of BD in this sample, limiting generalizability. Unavailable genetic data reduced sample size for some analyses.</p><p><strong>Conclusion: </strong>Findings support a genetic continuity between dimensional and categorical models of BD and suggest that the MDQ is a useful phenotype measure for genetic studies of BD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"394-401"},"PeriodicalIF":4.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter to editor about \"Letter to the editor: Waist-to-weight index and cognitive impairment: Understanding the link through depression mediation in the NHANES\".","authors":"Shaojie Li, Baofang Wu, Hongzhi Gao","doi":"10.1016/j.jad.2024.12.037","DOIUrl":"10.1016/j.jad.2024.12.037","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"420-421"},"PeriodicalIF":4.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifactorial influences on childhood insomnia: Genetic, socioeconomic, brain development and psychopathology insights.","authors":"Xiaolong Zhang, Yuqing Sun, Meng Wang, Yuxin Zhao, Jie Yan, Qin Xiao, Haolei Bai, Zhongxiang Yao, Yaojing Chen, Zhanjun Zhang, Zhian Hu, Chao He, Bing Liu","doi":"10.1016/j.jad.2024.12.031","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.031","url":null,"abstract":"<p><p>Insomnia is the most prevalent sleep disturbance during childhood and can result in extensively detrimental effects. Children's insomnia involves a complex interplay of biological, neurodevelopmental, social-environmental, and behavioral variables, yet remains insufficiently addressed. This study aimed to investigate the multifactorial etiology of childhood insomnia from its genetic architecture and social-environmental variables to its neural instantiation and the relationship to mental health. This cohort study uses 4340 participants at baseline and 2717 participants at 2-year follow-up from the Adolescent Brain Cognitive Development (ABCD) Study. We assessed the joint effects of polygenic risk score (PRS) and socioeconomic status (SES) on insomnia symptoms and then investigated the underlying neurodevelopmental mechanisms. Structural equation model (SEM) was applied to investigate the directional relationships among these variables. SES and PRS affected children's insomnia symptoms independently and additively (SES: β = -0.089, P = 1.91 × 10^-8; PRS: β = 0.041, P = 0.008), which was further indirectly mediated by the deviation of inferior precentral sulcus (β = 0.0027, P = 0.0071). SEM revealed that insomnia (β = 0.457, P < 0.001) and precentral development (β = -0.039, P = 0.009) significantly mediated the effect of SES_PRS (accumulated risks of PRS and SES) on psychopathology symptoms. Furthermore, baseline insomnia symptoms, SES_PRS, and precentral deviation significantly predicted individual total psychopathology syndromes (r = 0.346, P < 0.001). These findings suggest the additive effects of genetic and socioenvironmental factors on childhood insomnia via precentral development and highlight potential targets in early detection and intervention for childhood insomnia.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the evidence base for university counseling services and their effectiveness using CORE measures: A systematic review and meta-analysis.","authors":"Caitlin Collins, Emma Broglia, Michael Barkham","doi":"10.1016/j.jad.2024.12.022","DOIUrl":"10.1016/j.jad.2024.12.022","url":null,"abstract":"<p><strong>Background: </strong>The Clinical Outcomes in Routine Evaluation Outcome Measure (CORE-OM) is a pantheoretical measure of psychological functioning. Use of routine outcome measures (ROMs) assessing university counseling outcomes (i.e., clinical effectiveness) are essential to demonstrate evidence-based practice. But the evidence in higher education is limited as data usage and adoption of ROMs are not inherent within services, restricting knowledge of their effectiveness. This systematic review and meta-analysis document the evidence-base for in-house university counseling services (UCSs) and use of ROMs.</p><p><strong>Methods: </strong>The review protocol was pre-registered on PROSPERO doi:tinyurl.com/2vw5464d and reported following PRISMA guidelines. Scopus, PsycInfo, Opengrey, reference lists, and Sheffield Star Plus were searched March 22nd, 2021 and May 29th, 2024. Subgroup analyses explored the effectiveness of services using multiple therapies compared to a single therapy.</p><p><strong>Results: </strong>15 studies (N = 28,237) were included in the narrative synthesis and 13 studies (N = 14,795) included in a meta-analysis. CORE-OM data showed a large pre-post effect size (g = 1.19) demonstrating a reduction in students' psychological distress. The effect size for services using a range of therapies was significantly larger (g = 1.34) than those using a single therapy (g = 0.90).</p><p><strong>Limitations: </strong>The small number of papers demonstrates the limited body of evidence evaluating the effectiveness of UCSs. Lack of follow-up rates, likely due to limited ROM adoption, also hindered the evaluation.</p><p><strong>Conclusions: </strong>Quality of studies was good and UCSs are more effective than comparative CORE-OM benchmark data of no treatment derived from a large dataset of psychological therapy services.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"451-462"},"PeriodicalIF":4.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gendered outcomes? Educational assortative marriages, gender ideology, and depressive symptoms in China.","authors":"Menghan Zhao, Yang Zhang","doi":"10.1016/j.jad.2024.12.033","DOIUrl":"10.1016/j.jad.2024.12.033","url":null,"abstract":"<p><strong>Background: </strong>Traditionally, the educational hypergamy dominates in most societies due to men's higher educational attainment and advantages in market work. Women in hypogamy showed greater physical and mental health disadvantages because it goes against the traditional gender ideology about marriage and results in stress. However, the recent rise in women's education and the subsequent changes in people's attitude toward assortative marriages may alter this association.</p><p><strong>Methods: </strong>Using four waves of data from the nationally representative survey-China Family Panel Studies (2012-2020, N = 31,884), we paired married respondents with their spouses and examined how educational assortative marriages were related to the depressive symptoms of wives and husbands by multilevel linear model analyses. We also tested how gender ideology about marriage might moderate this association.</p><p><strong>Results: </strong>Compared to those in homogamy, women in hypergamy (hypogamy) were less (more) depressed, while men in hypergamy (hypogamy) were more (less) depressed. Traditional gender ideology led to even more depressive symptoms among wives in hypogamy.</p><p><strong>Limitations: </strong>The findings should be interpreted as associational rather than causal, because we cannot establish a causal relationship without individuals' depressive symptoms before marriage, though a wide range of confounders has been controlled.</p><p><strong>Conclusions: </strong>Against the conventional expectation that hypogamy leads to more depressive symptoms, both women and men who had less-educated spouses than themselves exhibited more depressive symptoms, whereas those with more-educated spouses were less depressed. Aside from the traditional gender norms, the practical needs, such as higher living standards and socioeconomic status, might influence how educational assortative marriages affect people's depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"463-469"},"PeriodicalIF":4.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}