Journal of affective disorders最新文献

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Internet access during COVID-19 and depressive symptoms in middle-aged and older adults: Evidence from a quasi-experimental study in China 在 COVID-19 期间上网与中老年人的抑郁症状:来自中国一项准实验研究的证据。
IF 4.9 2区 医学
Journal of affective disorders Pub Date : 2024-09-03 DOI: 10.1016/j.jad.2024.08.233
{"title":"Internet access during COVID-19 and depressive symptoms in middle-aged and older adults: Evidence from a quasi-experimental study in China","authors":"","doi":"10.1016/j.jad.2024.08.233","DOIUrl":"10.1016/j.jad.2024.08.233","url":null,"abstract":"<div><h3>Background</h3><p>Amid the COVID-19 pandemic, the mental health of middle-aged and older adults has become an increasing concern, and the role of the internet in addressing this public health crisis has drawn the attention of researchers. This study evaluated the impact of internet access during COVID-19 on depressive symptoms among middle-aged and older adults.</p></div><div><h3>Methods</h3><p>Data were derived from China Health and Retirement Longitudinal Study (CHARLS) 2018 and 2020. Difference-in-differences analysis was performed to compare changes in depressive symptoms between the internet users during COVID-19 and those who didn't have access to the internet before and during the pandemic.</p></div><div><h3>Results</h3><p>We found that internet access during COVID-19 pandemic significantly reduced middle-aged and older adults' depressive symptoms. Further investigation identified the underlying mechanisms through which internet access helps in alleviating depressive symptoms by reducing the likelihood of experiencing negative emotions about COVID-19. Heterogeneity analyses showed that rural residents and middle-aged individuals benefited more from internet access during the pandemic.</p></div><div><h3>Conclusions</h3><p>Since internet access can alleviate middle-aged and older adults' depressive symptoms amidst public health crisis, policy makers should focus on enhancing their access to the internet.</p></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LUTS/BPH increases the risk of depressive symptoms among elderly adults: A 5-year longitudinal evidence from CHARLS LUTS/BPH会增加老年人出现抑郁症状的风险:来自 CHARLS 的 5 年纵向证据。
IF 4.9 2区 医学
Journal of affective disorders Pub Date : 2024-09-03 DOI: 10.1016/j.jad.2024.08.205
{"title":"LUTS/BPH increases the risk of depressive symptoms among elderly adults: A 5-year longitudinal evidence from CHARLS","authors":"","doi":"10.1016/j.jad.2024.08.205","DOIUrl":"10.1016/j.jad.2024.08.205","url":null,"abstract":"<div><h3>Objective</h3><p>The prevalence of Lower Urinary Tract Symptoms suggestive of Benign Prostatic Hyperplasia (LUTS/BPH) is notably high and potentially elevates the likelihood of depressive symptoms. This study was designed to employ both cross-sectional and longitudinal methodologies to explore the correlation between LUTS/BPH and depressive symptoms among middle-aged and elderly men in China.</p></div><div><h3>Methods</h3><p>This investigation utilized data from the China Health and Retirement Longitudinal Study (CHARLS), with the initial dataset from 2015 serving as the baseline and subsequent data from 2018 and 2020 facilitating longitudinal analysis. The study encompassed a baseline cohort of 5156 men aged 45 years and above, and an expansive longitudinal analytical sample of 23,530 participants spanning from 2015 to 2020. The assessment of depressive symptoms was conducted using the 10-item Center for Epidemiological Studies Depressive Symptoms Scale (CESD-10). To investigate the factors associated with LUTS/BPH, the relationship between LUTS/BPH and depressive symptoms, and to evaluate the incidence rate of depressive symptoms onset based on LUTS/BPH status, multivariate logistic analyses and logistic regression models were employed.</p></div><div><h3>Results</h3><p>Our results reveal a markedly higher incidence of depressive symptoms among individuals with LUTS/BPH, at 30.16 %, compared to 22.94 % in those without LUTS/BPH. This pattern was consistent in both mild and moderate depressive symptoms categories. However, the prevalence of severe depressive symptoms did not exhibit a significant disparity between the two groups. Longitudinal analysis spanning from 2015 through 2018 and 2020 further corroborated these observations. Individuals with LUTS/BPH showed a substantially higher incidence of depressive symptoms across all severity levels compared to those without LUTS/BPH. Specifically, the presence of LUTS/BPH was linked to a 53 % heightened risk of mild depressive symptoms, a 45 % increase in moderate depressive symptoms, and an alarming 229 % surge in severe depressive symptoms risk between 2015 and 2018. Additionally, from 2015 to 2020, there was a 30 % increased risk for mild depressive symptoms, a 41 % rise for moderate depressive symptoms, and a 106 % escalation in the risk of severe depressive symptoms among those with LUTS/BPH.</p></div><div><h3>Conclusion</h3><p>In middle-aged and older Chinese adults, LUTS/BPH were correlated with an elevated risk of depressive symptoms.</p></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of family climate on problematic internet use: Findings from one nationwide study in China 家庭氛围对问题网络使用的影响:中国一项全国性研究的结果。
IF 4.9 2区 医学
Journal of affective disorders Pub Date : 2024-09-03 DOI: 10.1016/j.jad.2024.09.010
{"title":"The impact of family climate on problematic internet use: Findings from one nationwide study in China","authors":"","doi":"10.1016/j.jad.2024.09.010","DOIUrl":"10.1016/j.jad.2024.09.010","url":null,"abstract":"<div><h3>Background</h3><p>With the growing attention paid to problematic internet use (PIU), this study aims to i) explore the prevalence of PIU based on a nationally representative sample and ii) propose and validate the theoretical model that correlates family climate with PIU.</p></div><div><h3>Methods</h3><p>One national cross-sectional study was conducted with probability sampling and stratified sampling. Overall, 21,854 sample were included and analyzed. Validated measures of family climate, loneliness, and PIU was distributed and collected from June 2022 to August 2022.</p></div><div><h3>Results</h3><p>The overall prevalence of PIU in the sample population is approximately 30.86 %. The model findings showed that family communication and family health had indirect effects of −0.12 and − 0.05 on PIU by the mediating effects of loneliness. The indirect effect explained 80.0 % of the total effect of family communication on PIU and 38.5 % of family health on PIU, highlighting the dominance effects of path family communication and PIU via loneliness. Extended family type (−0.047, <em>p</em> = 0.050), low family income (income≤3000 group, −0.127, <em>p</em> &lt; 0.001) were identified as protective factors against PIU, while not living with family members (0.034, <em>p</em> = 0.021) was identified as risk factors of PIU.</p></div><div><h3>Limitations</h3><p>The nature of cross-sectional data have the limitation of preventing examining the casual relationships of PIU and the loneliness and family climate, in which future longitudinal study design is needed.</p></div><div><h3>Conclusions</h3><p>The high prevalence of PIU should be given adequate attention. Optimizing the family climate or family atmosphere by improving positive communication skills, providing family support and family health external resources can be served as effective strategies for controlling PIU.</p></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approach and withdrawal from cognitively effortful activities: Development, validation, and transdiagnostic clinical utility of a cognitive motivation scale 认知努力活动的接近和退出:认知动机量表的开发、验证和跨诊断临床实用性。
IF 4.9 2区 医学
Journal of affective disorders Pub Date : 2024-09-03 DOI: 10.1016/j.jad.2024.08.230
{"title":"Approach and withdrawal from cognitively effortful activities: Development, validation, and transdiagnostic clinical utility of a cognitive motivation scale","authors":"","doi":"10.1016/j.jad.2024.08.230","DOIUrl":"10.1016/j.jad.2024.08.230","url":null,"abstract":"<div><h3>Background</h3><p>Deficits in cognition and motivation predict functioning in depressive and psychotic disorders. However, experimental tasks of cognitive motivation are inconsistently correlated with functioning, time-intensive, and not intuitive in clinical practice. We aimed to develop and validate a self-report instrument to assess motivation processes pertinent to engagement with cognitive activities in daily life.</p></div><div><h3>Method</h3><p>Following item generation, scale dimensionality, reliability, and validity were evaluated iteratively over Studies 1–3 with online general adult participants (n<sub>1</sub> = 205; n<sub>2</sub> = 235; n<sub>3</sub> = 181). The 20-item Cognitive Motivation scale was also validated in a Study 3 sub-sample reporting high levels of depressive symptoms (<em>n</em> = 74) and Study 4 early psychosis outpatients (<em>n</em> = 25).</p></div><div><h3>Results</h3><p>Two-factor model of cognitive approach and cognitive withdrawal, each with good internal consistency, convergent validity, discriminant validity was supported. Cognitive withdrawal showed stronger associations with cognitive difficulties, depressive symptoms, and functional impairments than traditional motivation scale. Participants reporting high depression levels showed more severe difficulties with cognitive motivation than participants reporting low depression levels. In early psychosis outpatients, correlations with functioning and cognitive effort expenditure provided support for scale validity.</p></div><div><h3>Limitations</h3><p>Cross-sectional data collection restricted evaluation of repeated administration psychometric properties. Scale validation was mostly established in online community samples and a small patient sample during the COVID-19 pandemic, thereby limiting generalizability of clinical applications.</p></div><div><h3>Conclusions</h3><p>Cognitive Motivation scale is a promising tool for future intervention trials seeking to target motivational processes associated with functioning in the general population and potentially across patient groups with amotivation symptoms.</p></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the moderated mediation of stress and media use: Social support's impact on anxiety among older adults during the COVID-19 pandemic - Insights from a large-scale cross-sectional study in China 探索压力与媒体使用之间的中介作用:COVID-19大流行期间社会支持对老年人焦虑的影响--来自中国大规模横断面研究的启示。
IF 4.9 2区 医学
Journal of affective disorders Pub Date : 2024-09-03 DOI: 10.1016/j.jad.2024.09.011
{"title":"Exploring the moderated mediation of stress and media use: Social support's impact on anxiety among older adults during the COVID-19 pandemic - Insights from a large-scale cross-sectional study in China","authors":"","doi":"10.1016/j.jad.2024.09.011","DOIUrl":"10.1016/j.jad.2024.09.011","url":null,"abstract":"<div><h3>Background</h3><p>This study aimed to assess the prevalence of anxiety symptoms among the older adults, explore whether stress mediated the association between social support and anxiety symptoms, and investigate whether media use moderated the direct or indirect effects within the mediation model.</p></div><div><h3>Methods</h3><p>Questionnaires and scales were employed to collect data from 1143 individuals aged 60 years and older across 120 cities in China during the COVID-19 pandemic. The collected information encompassed sociodemographic characteristics, social support, anxiety, stress, and media use. Bivariate correlations were then used to analyze the relationships among the study variables. Finally, the mediation and moderated mediation models were examined using the PROCESS macro for SPSS.</p></div><div><h3>Results</h3><p>During the COVID-19 pandemic, 40.1 % of Chinese elderly experienced anxiety. Social support exhibited a negative correlation with anxiety. And, media use positively influenced both stress and anxiety. Stress partially mediated the relationship between social support and anxiety, with a mediation effect of 50.95 %. Notably, media use moderated the association between social support and anxiety, serving as both an indirect mediator (path a: Social support - Stress: B = 0.071, 95 % CI: 0.022, 0.120) and a direct mediator (path c’: Social support - Anxiety: B = −0.066, 95 % CI: −0.111, −0.022).</p></div><div><h3>Limitations</h3><p>This study used a cross-sectional design, which restricts the ability to infer causal relationships.</p></div><div><h3>Conclusion</h3><p>Social support is proven to be a potent alleviator of anxiety among the elderly. Stress partially mediated this relationship, while the indirect and direct impact of this mediation was influenced by media use.</p></div><div><h3>Brief summary</h3><p>This study underscores the heightened anxiety prevalence among Chinese elderly during the COVID-19 pandemic, emphasizing the critical role of social support in mitigating these effects. It discovers that while stress acts as a mediator, media use serves as a significant moderator in this dynamic. These findings advocate for the necessity of bolstering social support networks and encouraging prudent media use to effectively manage anxiety and stress among the elderly, particularly in challenging times like a pandemic.</p></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the network ties between affect, attachment, and psychopathology 调查情感、依恋和精神病理学之间的网络联系。
IF 4.9 2区 医学
Journal of affective disorders Pub Date : 2024-09-03 DOI: 10.1016/j.jad.2024.08.219
{"title":"Investigating the network ties between affect, attachment, and psychopathology","authors":"","doi":"10.1016/j.jad.2024.08.219","DOIUrl":"10.1016/j.jad.2024.08.219","url":null,"abstract":"<div><h3>Objectives</h3><p>Recent years have seen an increased interest regarding theoretical and empirical associations of adult attachment security and primary affective traits concerning psychiatric disorders. In this study, network analysis technique is applied to dissect the links between both psychodynamic personality constructs and an array of psychopathological symptoms.</p></div><div><h3>Methods</h3><p>A total sample of 921 (69.9 % female) participants from the general population was investigated. A regularized cross-sectional partial correlation network between attachment (Experiences in Close Relationships-Revised [ECR-RD8]), primary affective traits (Brief Affective Neuroscience Personality Scales [BANPS-GL]) and psychopathological symptoms (ICD-10-Symptom-Rating Questionnaire [ISR]) was estimated via the EBICglasso algorithm. Node centrality, predictability and bridge centrality were analyzed. To evaluate the stability of the network and evaluate the significance of differences, we employed bootstrap techniques.</p></div><div><h3>Results</h3><p>The network was found to be stable, allowing reliable interpretations. We observed SADNESS, as well as depressive, PTSD and anxiety symptoms as the most influential nodes within the investigated network. Attachment AV and SADNESS were observed as nodes with the highest bridge centrality.</p></div><div><h3>Conclusions</h3><p>The results provide a data-driven in-depth look into the complex dynamics between psychopathological symptoms, attachment security and basic affective traits. Results underscore the critical interconnections between affect, attachment, and psychopathology, advocating for a psychodynamically informed systems approach in psychological research that considers the affective dimensions underlying human mental health.</p></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165032724014563/pdfft?md5=13e679eb32b45ad0717e43847445bb7b&pid=1-s2.0-S0165032724014563-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early affective empathy, emotion contagion, and empathic concern in borderline personality disorder: A systematic review and meta-analysis 边缘型人格障碍的早期情感共情、情感传染和共情关注:系统回顾与荟萃分析。
IF 4.9 2区 医学
Journal of affective disorders Pub Date : 2024-09-03 DOI: 10.1016/j.jad.2024.08.215
{"title":"Early affective empathy, emotion contagion, and empathic concern in borderline personality disorder: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.jad.2024.08.215","DOIUrl":"10.1016/j.jad.2024.08.215","url":null,"abstract":"<div><h3>Background</h3><p>Individuals with Borderline Personality Disorder (BPD) are theorized to experience lower cognitive empathy but heightened affective empathy. Despite meta-analyses addressing cognitive empathy, affective empathy remains unexplored. This pre-registered systematic review and meta-analysis investigated affective empathy in individuals with BPD or high BPD traits relative to healthy comparisons, using a multidimensional approach including, early affective empathy, emotion contagion, and empathic concern.</p></div><div><h3>Methods</h3><p>Systematic search of SCOPUS, PubMed, Medline COMPLETE, and PsycINFO (June 27, 2022, May 14, 2023, and July 1, 2024) was completed. Included studies compared affective empathy in those with BPD/high BPD traits with healthy comparisons, utilized experimental or self-report designs, and were peer-reviewed or PhD theses. Risk of bias was assessed using the Newcastle-Ottawa Scale.</p></div><div><h3>Results</h3><p>Among 22 eligible studies identified, results revealed individuals with BPD/high BPD traits showed significantly higher emotion contagion (<em>N</em><sub><em>pooled</em></sub> <em>=</em> 1797, <em>g</em> <em>=</em> −1.10, 95 % CI [−1.57, −0.62]). No significant differences were found in empathic concern (<em>N</em><sub><em>pooled</em></sub> <em>=</em> 1545, <em>g</em> = 0.06, 95 % CI [−0.10, 0.22]), or early affective empathy for anger <em>(N</em><sub><em>pooled</em></sub> <em>= 245</em>, <em>g</em> <em>=</em> 0.28, 95 % CI [−0.0.53, 1.09]) and happiness, (<em>N</em><sub><em>pooled</em></sub> <em>= 189</em>, <em>g</em> = 0.34, 95 % CI [−0.1.50, 2.18]).</p></div><div><h3>Limitations</h3><p>Few included studies for early affective empathy, methodological shortcomings in the broader literature and study heterogeneity suggest caution when interpreting these effects, emphasizing the need for targeted research.</p></div><div><h3>Conclusions</h3><p>While individuals with BPD/high BPD traits are more likely to subjectively experience others' distress through emotion contagion, no differences were found in early affective empathy or ability to direct sympathy and concern towards others.</p></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social anxiety prediction based on ERP features: A deep learning approach 基于ERP特征的社交焦虑预测:深度学习方法
IF 4.9 2区 医学
Journal of affective disorders Pub Date : 2024-09-03 DOI: 10.1016/j.jad.2024.09.006
{"title":"Social anxiety prediction based on ERP features: A deep learning approach","authors":"","doi":"10.1016/j.jad.2024.09.006","DOIUrl":"10.1016/j.jad.2024.09.006","url":null,"abstract":"<div><h3>Background</h3><p>Social Anxiety Disorder is traditionally diagnosed using subjective scales that may lack accuracy. Recently, EEG technology has gained importance for anxiety detection due to its ability to capture stable and objective neurophysiological activities. However, existing methods mainly focus on extracting EEG features during resting states, with limited use of psychologically features like Event-Related Potential (ERP) in task-related states for anxiety detection in deep learning frameworks.</p></div><div><h3>Methods</h3><p>We collected EEG data from 63 participants exposed to four facial expressions and extracted task-relevant features. Using the EEGNet model, we predicted social anxiety and evaluated its performance using metrics such as accuracy, F1 score, sensitivity, and specificity. We compared EEGNet's performance with Deep Convolutional Neural Network (DeepConvNet), ShallowConvNet, Bi-directional Long Short-Term Memory (BiLSTM), and SVM. To assess the generalizability of the results, we carried out the same procedure on our prior dataset.</p></div><div><h3>Results</h3><p>EEGNet outperformed other models, achieving 99.16 % accuracy with Late Positive Potential (LPP). ERP components yielded higher accuracy than time-domain and frequency-domain features for social anxiety recognition. Accuracy was better for neutral and negative facial stimuli. Consistency across two datasets indicates stability of findings.</p></div><div><h3>Limitations</h3><p>Due to limited publicly available task-state datasets, only our own were used. Future studies could assess generalizability on larger datasets from different sources.</p></div><div><h3>Conclusions</h3><p>We conducted the first test of ERP features in anxiety recognition tasks. Results show ERP features have greater potential in social anxiety recognition, with LPP exhibiting high stability and accuracy. Outcomes indicate recognizing social anxiety with negative or neutral facial stimuli is more useful.</p></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of arketamine on depression-like behaviors and demyelination in mice exposed to chronic restrain stress: A role of transforming growth factor-β1 阿克他敏对慢性抑制应激小鼠抑郁样行为和脱髓鞘的影响:转化生长因子-β1的作用
IF 4.9 2区 医学
Journal of affective disorders Pub Date : 2024-09-03 DOI: 10.1016/j.jad.2024.08.222
{"title":"Effects of arketamine on depression-like behaviors and demyelination in mice exposed to chronic restrain stress: A role of transforming growth factor-β1","authors":"","doi":"10.1016/j.jad.2024.08.222","DOIUrl":"10.1016/j.jad.2024.08.222","url":null,"abstract":"<div><h3>Background</h3><p>Chronic restrain stress (CRS) induces depression-like behaviors and demyelination in the brain; however, the relationship between these depression-like behaviors and demyelination remains unclear. Arketamine, the (<em>R</em>)-enantiomer of ketamine, has shown rapid antidepressant-like effects in CRS-exposed mice.</p></div><div><h3>Methods</h3><p>We examined whether arketamine can improve both depression-like behaviors and demyelination in the brains of CRS-exposed mice. Additionally, we investigated the role of transforming growth factor β1 (TGF-β1) in the beneficial effects of arketamine.</p></div><div><h3>Results</h3><p>A single dose of arketamine (10 mg/kg) improved both depression-like behavior and demyelination in the corpus callosum of CRS-exposed mice. Correlations were found between depression-like behaviors and demyelination in this region. Furthermore, pretreatment with RepSox, an inhibitor of TGF-β1 receptor, significantly blocked the beneficial effects of arketamine on depression-like behaviors and demyelination in CRS-exposed mice. Finally, a single intranasal administration of TGF-β1 ameliorated both depression-like behaviors and demyelination in CRS-exposed mice.</p></div><div><h3>Limitations</h3><p>The precise mechanisms by which TGF-β1 contributes to the effects of arketamine remain unclear.</p></div><div><h3>Conclusions</h3><p>These data suggest that CRS-induced demyelination in the corpus callosum may contribute to depression-like behaviors, and that arketamine can mitigate these changes through a TGF-β1-dependent mechanism.</p></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165032724014538/pdfft?md5=08b8c12466cabdf7e08e2409f4a90cff&pid=1-s2.0-S0165032724014538-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevalence of 12-month suicidal ideation and associated factors among university students in China: Findings from a three-wave cross-sectional study from 2021 to 2023 中国大学生12个月内的自杀倾向及相关因素:2021-2023年三波横断面研究结果。
IF 4.9 2区 医学
Journal of affective disorders Pub Date : 2024-09-03 DOI: 10.1016/j.jad.2024.08.232
{"title":"The prevalence of 12-month suicidal ideation and associated factors among university students in China: Findings from a three-wave cross-sectional study from 2021 to 2023","authors":"","doi":"10.1016/j.jad.2024.08.232","DOIUrl":"10.1016/j.jad.2024.08.232","url":null,"abstract":"<div><h3>Background</h3><p>Many studies have shown that the COVID-19 pandemic has increased the risk of suicidal tendencies among the public. However, there is limited research reporting on the changing trends in suicidal ideation after 2020 in the context of the long-term normalization of COVID-19 prevention and control measures in China.</p></div><div><h3>Methods</h3><p>The self-administered online questionnaire was adopted to collect 12-month suicidal ideation, depressive symptoms, anxiety symptoms, stress, and some demographic information from university students by convenient cluster sampling in Shandong, Shaanxi, and Jilin Provinces, China. Multivariate logistic regressions were performed to assess the association between different factors and suicidal ideation.</p></div><div><h3>Results</h3><p>The prevalence of 12-month suicidal ideation from 2021 to 2023 among university students was 3.89 %, 5.81 %, and 4.33 %, respectively, showing a trend of first increasing and then decreasing. The trends presented a similar tendency in the subgroups according to gender, majors, and grades, except among urban freshman-year students. The associated factors of suicidal ideation were different among university students in different surveys. However, female gender, poor mental health, and depressive symptoms were linked to a higher risk of suicidal ideation.</p></div><div><h3>Limitations</h3><p>More representative large-scale longitudinal studies should be used to monitor the suicidal behavior of university students.</p></div><div><h3>Conclusions</h3><p>The prevalence of 12-month suicidal ideation among Chinese university students exhibited a pattern of initial increase followed by a subsequent decrease from 2021 to 2023. Despite the complete lifting of COVID-19 prevention and control measures in China, the prolonged three-year epidemic may have enduring adverse effects on university students, underscoring the ongoing importance of providing continuous mental health services to this population.</p></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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