Journal of affective disorders最新文献

{"title":"Exploring the association between urticaria subtypes, anxiety, and depression and potential role of gut microbiota","authors":"Xiang Li ,&nbsp;Xiaojun Wang ,&nbsp;Linping Zhu ,&nbsp;Jianqun Liu ,&nbsp;Jianyi Wang ,&nbsp;Xiaochun Chen","doi":"10.1016/j.jad.2025.03.112","DOIUrl":"10.1016/j.jad.2025.03.112","url":null,"abstract":"<div><h3>Aims</h3><div>In observational studies, the causal relationship between urticaria and the risk of psychiatric disorders (anxiety and depression) remains inconclusive. Furthermore, there is growing evidence that gut microbiota (GM) contributes to the pathogenesis of urticaria. This study aimed to assess the causal relationships between the genetically predicted urticaria subtypes and psychiatric disorders and further examined the role of GM in influencing the risk of these urticaria subtypes.</div></div><div><h3>Methods</h3><div>We conducted a meta-analysis of observational studies identified from four databases to evaluate the associations between urticaria, anxiety, and depression over the past decade. In addition, we estimated the genetic correlation and causality between genetically predicted urticaria subtypes and psychiatric disorders using linkage disequilibrium score regression and Mendelian Randomization (MR) analyses. Finally, univariable two-sample MR and multivariable MR analyses were employed to evaluate the combined and independent effects of GM from two datasets on urticaria subtypes associated with psychiatric disorders.</div></div><div><h3>Results</h3><div>Thirteen observational studies comprising 7321 participants were included in the meta-analysis. There was a positive association between urticaria and anxiety risk (<em>n</em> = 13, OR: 3.96; 95%CI: 2.90–5.41) as well as depression risk (<em>n</em> = 12, OR: 3.03; 95%CI: 2.30–4.01). The MR results indicated that idiopathic urticaria increased the risk of anxiety (OR = 1.14; 95%CI = 1.01–1.28; <em>P</em> = 3.31 × 10⁻²), while allergic urticaria increased the risk of major depressive disorder (OR = 1.07; 95%CI = 1.02–1.13; <em>P</em> = 6.65 × 10⁻³). Our analysis identified nineteen gut bacterial taxa that were causally associated with idiopathic and allergic urticaria. Notably, <em>Intestinibacter</em> and <em>Victivallales</em> were strongly associated with an increased risk of allergic urticaria, even after accounting for the effect of smoking or alcohol consumption in the multivariable MR analysis. <em>FamilyXIIIAD3011group</em> and <em>Bacteroides vulgatus</em> were found to exert protective roles in idiopathic urticaria.</div></div><div><h3>Conclusions</h3><div>The study provides evidence for the association between urticaria subtypes and psychiatric disorders, complementing existing observational studies. In addition, our study implies the involvement of gut microbiota in idiopathic and allergic urticaria. However, the specific mechanisms of bacterial action remain to be clarified.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 181-190"},"PeriodicalIF":4.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of childhood emotional neglect, circulating protein biomarkers, with gastrointestinal disorders among UK biobank participants","authors":"Conghui Qiao ,&nbsp;Xiaowen Qin ,&nbsp;Yuqing Song ,&nbsp;Ruijie Guan ,&nbsp;Bai Li ,&nbsp;Yingdong Zuo ,&nbsp;Wei Wei ,&nbsp;Tianshu Han ,&nbsp;Wenbo Jiang","doi":"10.1016/j.jad.2025.03.114","DOIUrl":"10.1016/j.jad.2025.03.114","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the association between CEN and GIDs, and elucidated the potential role of circulating protein biomarkers.</div></div><div><h3>Patients and methods</h3><div>The study utilized UK Biobank data from 156,686 participants, with data collection occurring between March 13, 2006 and October 1, 2010. Participants with GIDs at baseline were excluded from further analysis. CEN data were obtained from the baseline assessments. Differential protein analyses were conducted using OLINK data. GIDs and their subclasses were identified through electronic health records. Cox proportional hazards regression models were employed to assess the association between CEN and the risk of GIDs, along with sensitivity and multidimensional stratification analyses. Additionally, mediation analysis was performed to explore the role of differential protein biomarkers.</div></div><div><h3>Results</h3><div>The results indicated that the mild CEN (CEN_mild) group was associated with a significantly lower risk of various GIDs than the severe CEN (CEN_severe) group, including overall GIDs (HR = 0.78,95%CI:0.74–0.81) and peptic ulcers (HR = 0.37,95%CI:0.20–0.68). OLINK differential analysis revealed that APOF expression was significantly higher in the CEN_mild group compared to the CEN_severe group (<em>P</em>_APOF = 7.09E-08,FC = 0.048), whereas other differential protein expression (<em>P</em>_BPIFB2 = 8.93E-06,FC = -0.122;<em>P</em>_FABP4 = 3.19E-06,FC = -0.101;<em>P</em>_GGH = 4.58E-07,FC = -0.054;<em>P</em>_LEP = 5.39E-08,FC = -0.195) was significantly lower in the CEN_severe group. Cox regression analysis showed that higher APOF expression was associated with a reduced risk of multiple GIDs, while the expression of other differential proteins increased the risk of corresponding GIDs. Mediation analysis indicated that these proteins mediated 0.5 % to 6.7 % of the CEN-GIDs association.</div></div><div><h3>Conclusion</h3><div>In this cohort study, CEN was significantly associated with a higher risk of GIDs in the adulthood, and circulating protein biomarkers partially mediated the associations.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 317-330"},"PeriodicalIF":4.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with suicidal ideation in drug-naïve patients with major depressive disorder.","authors":"Xueying Liu, Yanan Liu, Ying Gao, Chuhao Zhang, Chi Zhou, Shuhua Li, Meijuan Li, Jie Li","doi":"10.1016/j.jad.2025.03.111","DOIUrl":"https://doi.org/10.1016/j.jad.2025.03.111","url":null,"abstract":"<p><strong>Background: </strong>Inflammation and immune activation may be involved in the pathological processes of depression, but its role in suicidal ideation (SI) in major depressive disorder (MDD) remains to be elucidated. The present study aims to examine the differences of inflammatory markers between MDD patients with and without SI, and to construct a predictive panel using multi index to distinguish SI in MDD patients.</p><p><strong>Methods: </strong>A total of 151 first-episode drug-naïve MDD patients were recruited for this study. SI was identified using the Chinese Version of Beck Scale for Suicide Ideation (BSI-CV). Based on the results of this scale, the subjects were divided into two groups: MDD with SI (n = 91) and MDD without SI (n = 60). Hamilton Depression Rating Scale-17 (HAMD-17) was used to assess depression symptoms. Plasma concentrations of interleukin-6 (IL-6), tumor necrosis factor (TNF-α), superoxide dismutase (CAT), and superoxide dismutase (SOD) have been measured.</p><p><strong>Results: </strong>Age (OR = 0.87, 95%CI 0.81-0.93, p < 0.001), HAMD retardation factor score (OR = 1.49, 95%CI 1.18-1.88, p < 0.001), and plasma IL-6 concentration (OR = 1.03, 95%CI 1.00-1.06, p = 0.041) were statistically significant on SI in MDD patients, we constructed a good predictive panel to distinguish SI in patients with MDD by combining age, marital status, HAMD retardation factor score, and plasma IL-6 concentration (AUC = 0.812, p < 0.001).</p><p><strong>Limitations: </strong>The study was cross-sectional, making it impossible to determine directionality or causality.</p><p><strong>Conclusions: </strong>Patients with younger age, single status, serious retardation symptom, and higher plasma IL-6 concentrations are more susceptible to experiencing SI in MDD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotropic comedication trends in long-term lithium treatment for older adults with bipolar disorder: A 10-year analysis","authors":"Olaf Paans ,&nbsp;Jay L. Tilborg ,&nbsp;Astrid M. Kamperman ,&nbsp;Ralph W. Kupka ,&nbsp;Rob M. Kok","doi":"10.1016/j.jad.2025.03.091","DOIUrl":"10.1016/j.jad.2025.03.091","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;The prescription of psychotropic comedications in patients with bipolar disorder (BD) evolved between 1995 and 2010. This study provides a comprehensive overview of prescription trends across various classes of psychotropic comedications, alongside lithium treatment, in older adults (aged ≥55 years) with BD, from 2010 to 2019.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This naturalistic, retrospective cohort study included 166 older adults (mean age 67.4 years) treated with lithium. Medical files from a large mental healthcare provider in the Netherlands were used to construct Lifecharts. The average proportion of time that different classes of comedications were prescribed during follow-up was calculated.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Patients received psychotropic comedications next to lithium for 75.8 % of total follow-up time. Benzodiazepines were prescribed for 56.2 % of follow-up time, antidepressants for 31.6 %, atypical antipsychotics for 25.9 %, a second mood stabilizer for 18.4 %, and typical antipsychotics for 8.7 %. Most classes of comedications did not show significant changes in prescription trends over the 10-year observation period. Quetiapine at doses below 50 mg/day was prescribed significantly more over time (&lt;em&gt;p&lt;/em&gt; = .033), its prescription duration increasing from 2.0 % of total follow-up time in 2010 to 8.1 % in 2019.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Limitations&lt;/h3&gt;&lt;div&gt;Generalizability is limited due to focus on older lithium-treated BD patients, potential selection bias, and retrospective design.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Long-term lithium treatment in older adults is mostly combined with other psychotropic medications. Frequent and prolonged use of benzodiazepines and significant increase of low-dose quetiapine use are concerning, given their adverse effects and lack of long-term efficacy. Prescription trends observed before 2010 have largely stabilized.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Plain language summary&lt;/h3&gt;&lt;div&gt;In this study, we examined what types of comedication were used alongside lithium in older adults with bipolar disorder between 2010 and 2019. For this purpose, we reviewed the medical records of 166 patients 55 years or older in the Netherlands. These patients were prescribed additional psychotropic medications along with lithium 75.8 % of the time. Benzodiazepines, often used to treat anxiety and sleep issues but not recommended for long-term use due to adverse effects, were the most frequently prescribed, namely 56.2 % of the time. Antidepressants were prescribed 31.6 % of the time, atypical antipsychotics 25.9 %, a second mood stabilizer 18.4 %, and typical antipsychotics 8.7 %. Although most prescription trends remained stable between 2010 and 2019, prescription time of low-dose quetiapine increased. We conclude that lithium maintenance treatment is mostly combined with other psychotropic comedications in older adults with bipolar disorder. Considering their potential adverse eff","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 366-374"},"PeriodicalIF":4.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between swallowing function and depressive symptoms among community-dwelling older adults: A cross-sectional study in Central China","authors":"Hongji Zeng ,&nbsp;Weijia Zhao ,&nbsp;Rui Wang ,&nbsp;Heping Li ,&nbsp;Liugen Wang ,&nbsp;Xi Zeng","doi":"10.1016/j.jad.2025.03.113","DOIUrl":"10.1016/j.jad.2025.03.113","url":null,"abstract":"<div><h3>Background</h3><div>Swallowing dysfunction and depressive symptoms are prevalent among older adults. This study explored the association between swallowing function and depressive symptoms among community-dwelling older adults.</div></div><div><h3>Methods</h3><div>This cross-sectional study included Chinese community-dwelling older adults (≥65 years old) in 2023, using cluster random sampling. Questionnaires were used to collect information on swallowing function (10-item Eating Assessment Tool), depressive symptoms (9-item Patient Health Questionnaire), sociodemographic characteristics, health status, and lifestyle. Multivariable logistic regression models and Directed Acyclic Graphs were used to identify factors associated with depressive symptoms. Propensity Score Matching (PSM) was used to explore the association between swallowing function and depressive symptoms.</div></div><div><h3>Results</h3><div>Totally, 8388 participants were included. The prevalences of depressive symptoms and swallowing dysfunction were 16.40 % (95 % CI: 15.52 %–17.19 %) and 22.06 % (95%CI: 19.86 %–24.25 %), respectively. The multivariate regression model showed that swallowing function was one of the factors associated with depressive symptoms (OR = 1.699, 95 % CI = 1.448–1.995, <em>P</em> &lt; 0.001). The risk ratio for depressive symptoms was significantly higher in the participants with swallowing dysfunction than those with normal swallowing function [(23.29 %, 431/1850) vs. (945/6538, 14.45 %), <em>P</em> &lt; 0.001] There were 17 out 38 of variates enrolled in the PSM covariate set. A total of 1850 pairs of participants were matched and PSM revealed a 6.64 % difference in the risk ratio for depressive symptoms [(23.29 %, 431/1850) vs. (16.65 %, 308/1850), P &lt; 0.001]. The PSM robustness test supported the stability and reliability of the results.</div></div><div><h3>Conclusions</h3><div>In Chinese community-dwelling older adults, swallowing dysfunction was positively associated with depressive symptoms.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 78-86"},"PeriodicalIF":4.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of age at help-seeking and duration of untreated illness (DUI) in obsessive-compulsive disorder (OCD): The need for early interventions","authors":"Luca Pellegrini ,&nbsp;Sofia Giobelli ,&nbsp;Sofia Burato ,&nbsp;Gabriele di Salvo ,&nbsp;Giuseppe Maina ,&nbsp;Umberto Albert","doi":"10.1016/j.jad.2025.03.090","DOIUrl":"10.1016/j.jad.2025.03.090","url":null,"abstract":"<div><h3>Introduction</h3><div>Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric disorder that often begins early in childhood. Patients with OCD are known to seek help late after disorder onset, and therefore have a long duration of untreated illness (DUI), which is found to correlate with negative clinical outcomes. No meta-analysis has previously investigated this issue.</div></div><div><h3>Methods</h3><div>Our protocol was pre-registered with PROSPERO (CRD42020165226). We followed PRISMA-guidelines and searched for relevant articles in four electronic databases. Meta-analyses of means based on random-effects (Der-Simonian-and-Laird-method) were used to derive the pooled estimates. Subgroup-analyses and meta-regressions were conducted to explore possible factors affecting help-seeking and DUI.</div></div><div><h3>Results</h3><div>We included <em>N</em> = 31 studies in the quantitative synthesis, with 16 studies proving data for age at help-seeking and 16 studies providing data for duration of untreated illness. The pooled mean age at help-seeking was 28.66 years (95 % CI: 27.34–29.98), while the pooled mean interval between age at disorder onset and help-seeking was 6.97 (95 % CI: 5.69–8.24), and the pooled mean duration of untreated illness was 80.23 months (68.72–91.75), around 6.69 years, all with <em>p</em> &lt; 0.001. Specific OCD-related factors affected help-seeking and duration of untreated illness.</div></div><div><h3>Conclusions</h3><div>Patients with OCD seek for help late in the course of the disorder and have a long duration of untreated illness, which is associated with more negative prognosis. This meta-analysis confirms the long duration of untreated illness in OCD and proposes possible factors associated with the length of the help-seeking process and DUI.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 212-225"},"PeriodicalIF":4.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of affective temperaments on sleep quality in a general population sample. Data report from the CHRIS study","authors":"Ettore Favaretto ,&nbsp;Martin Gögele ,&nbsp;Fulvio Bedani ,&nbsp;Simone Giovannini ,&nbsp;Peter P. Pramstaller ,&nbsp;Giulio Perugi ,&nbsp;Andreas Erfurth ,&nbsp;Gabriele Sani ,&nbsp;Andrew A. Hicks ,&nbsp;Roberto Melotti","doi":"10.1016/j.jad.2025.03.055","DOIUrl":"10.1016/j.jad.2025.03.055","url":null,"abstract":"<div><h3>Background</h3><div>Affective temperaments predispose to life adaptation and affective disorders. The relationship between temperaments and sleep quality is rarely investigated in community-based studies. We hypothesized that cyclothymic-related temperaments relate to worse sleep quality, whereas the hyperthymic temperament favours sleep quality.</div></div><div><h3>Method</h3><div>We investigated 3701 18 to 65 years old adults from the population-based CHRIS study in Italy. Participants were 54 % females, mean age 38.5 years. The Pittsburgh Sleep Quality Index (PSQI) was the primary outcome score. Five affective temperaments split into quartiles for direct comparison from the TEMPS-M questionnaire were the exposures of interest. Additional covariates comprised sex, age, trait anxiety, and sleep quality-related lifestyles assessed via interviews, self-administered questionnaires or instrumental measurements.</div></div><div><h3>Results</h3><div>The hyperthymic temperament showed a negative association (better sleep quality) with the global PSQI, whereas the cyclothymic-related temperaments had all associations in opposite direction. While inclusion of trait anxiety appeared to mediate some results, the anxious and other cyclothymic related temperaments were still directly associated with multiple dimensions of poor sleep quality.</div></div><div><h3>Limitations</h3><div>The cross-sectional design, possible selection into the study by temperamental background or sleep disorders, and no clinically validated self-assessed psychiatric constructs represent possible weaknesses.</div></div><div><h3>Conclusions</h3><div>Our findings support the hypothesis of a biological binary diathesis of affective temperaments, with hyperthymic and cyclothymic-related temperaments predisposing sleep quality in an antithetical way.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 162-170"},"PeriodicalIF":4.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between sugar-sweetened beverage consumption, moderate-to-vigorous physical activity duration and psychological symptoms in adolescents: A nationwide study in China","authors":"Nana Tang ,&nbsp;Jiarui Li ,&nbsp;Zhen Zhang","doi":"10.1016/j.jad.2025.03.069","DOIUrl":"10.1016/j.jad.2025.03.069","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of psychological symptoms among adolescents continues to increase. Sugar-sweetened beverage (SSB) consumption and moderate-to-vigorous physical activity (MVPA) duration are associated with psychological symptoms, respectively. However, few national studies have been conducted in developing countries, and there is a lack of research on the association between the combined effects of SSB consumption and MVPA duration and psychological symptoms in adolescents.</div></div><div><h3>Methods</h3><div>In this study, 50,222 adolescents aged 12–18 years nationwide in China were assessed cross-sectionally for SSB consumption, MVPA duration, psychological symptoms, and basic participant characteristics using stratified whole-cluster random sampling in 2023. The associations of SSB consumption, MVPA duration, and psychological symptoms were analyzed using nonparametric tests, <em>t</em>-tests, logistic regression analyses, and ordered logistic regression analyses with generalized linear models.</div></div><div><h3>Results</h3><div>The prevalence of psychological symptoms among Chinese adolescents is 20.1 %. The proportion of adolescents with SSB consumption &gt;4 times/week was 14.8 %. The results of ordered logistic regression analysis showed that the adolescents in the group with SSB consumption &lt;1 times/week and MVPA duration &gt;60 min/day were used as the reference group， adolescents in the group with SSB consumption &gt;4 times/week and MVPA duration &lt;30 min/day had the highest risk (OR = 2.28, 95 % CI: 1.98–2.64) of the prevalence of psychological symptoms (<em>P</em> &lt; 0.001). The same trend was observed in boys and girls.</div></div><div><h3>Conclusions</h3><div>SSB consumption, MVPA duration, and psychological symptoms were associated with each other in Chinese adolescents. Increasing SSB consumption and decreasing MVPA duration will lead to an increase in the prevalence of psychological symptoms in adolescents. In the future, SSB consumption and MVPA duration should be effectively controlled to reduce the prevalence of psychological symptoms and to promote the physical and mental health of Chinese adolescents.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 26-36"},"PeriodicalIF":4.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the associations between developmental disabilities and anxiety and depression symptoms among U.S. children: Insights from the 2021 National Health Interview Survey","authors":"Gloria Wang ,&nbsp;Muyiwa Ategbole ,&nbsp;Xingguang Luo ,&nbsp;Kesheng Wang ,&nbsp;Chun Xu","doi":"10.1016/j.jad.2025.03.092","DOIUrl":"10.1016/j.jad.2025.03.092","url":null,"abstract":"<div><h3>Background</h3><div>Limited research has explored the associations between developmental disabilities and symptoms of anxiety and depression among U.S. children during the COVID-19 pandemic.</div></div><div><h3>Objective</h3><div>This study investigates the associations between developmental disabilities and symptoms of anxiety and depression among U.S. children and examines whether these associations differ by gender.</div></div><div><h3>Methods</h3><div>The analysis included 6092 children aged 5–17 from the 2021 National Health Interview Survey (NHIS). Key risk factors for anxiety and depression symptoms included attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), intellectual disability (ID), learning disability (LD), and developmental delay (DD). Weighted multivariable logistic regression (MLR) was conducted to evaluate associations with anxiety and depression symptoms.</div></div><div><h3>Results</h3><div>The overall prevalence of anxiety was 14.8 % (12.8 % for males and 17.0 % for females), while depression prevalence was 5.1 % (4.2 % for males; and 6.0 % for females). Children with developmental disabilities had significantly higher prevalence rates of anxiety and depression compared to their peers without such conditions (<em>p</em> &lt; 0.05). MLR analysis revealed that being female and having a history of ADHD, ASD, LD, and DD were associated with increased odds of both anxiety and depression (p &lt; 0.05). ID was associated with increased odds of anxiety but not depression. COVID-19 was not significantly associated with either anxiety or depression. Furthermore, the associations of ASD, LD, ID, and DD with anxiety and depression varied by gender.</div></div><div><h3>Conclusions</h3><div>Developmental disabilities were significantly associated with symptoms of anxiety and depression among U.S. children in 2021, with notable gender differences. These findings highlight the importance of incorporating gender-sensitive approaches in designing effective prevention and intervention strategies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 154-161"},"PeriodicalIF":4.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial","authors":"Murat Açik ,&nbsp;Funda Pınar Çakiroğlu ,&nbsp;Atilla Tekin ,&nbsp;Aslı Egeli","doi":"10.1016/j.jad.2025.03.097","DOIUrl":"10.1016/j.jad.2025.03.097","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to compare the effects of krill- and fish-oil interventions on clinical symptoms and metabolic risk factors in individuals with MDD.</div></div><div><h3>Methods</h3><div>In this randomized study, 57 adults diagnosed with MDD were allocated to receive krill-oil (520 mg EPA + DHA), fish-oil (600 mg EPA + DHA), or a placebo (soybean-oil) daily for 8 weeks. Anthropometric measurements, depression anxiety stress-21 (DASS-21) scale, and Hamilton depression rating scale (HDRS) were performed at baseline and 4 and 8 weeks. In addition, venous blood samples were collected at baseline and post-intervention to evaluate lipid and glycemic profiles, including fasting glucose, HbA1c, cholesterol, triglycerides, LDL-c, and HDL-c levels.SPSS and R Studio software programs were used for statistical analysis.</div></div><div><h3>Results</h3><div>A total of 50 participants completed the study, with 17 in each intervention group and 16 in the placebo. The mean HDRS scores decreased significantly in both the krill-oil (8.5 ± 1.2) and fish-oil groups (10.0 ± 1.2) compared to the placebo (<em>p</em> &lt; 0.001), indicating clinical symptom improvement. Furthermore, the interaction effect of group-by-time was found to be statistically significant (η2p = 0.273;p_time×group &lt; 0.001). Anxiety and distress scores decreased to similar levels after the post-intervention compared to baseline in krill- and fish-oil groups. Krill- and fish-oil supplementation increased plasma HDL-c and uric acid levels, but the group-by-time interaction effect was only observed at the HDL-c level (η2p = 0.238;p_time×group = 0.002). The mean HbA1c rates and plasma triglyceride levels of krill-oil recipients were lower after the post-intervention.</div></div><div><h3>Conclusion</h3><div>Krill- and fish-oil could be considered as a safe and effective adjuvant treatments for depression. However, there was no evidence of apparent superiority over each other.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 171-180"},"PeriodicalIF":4.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}