Journal of affective disorders最新文献

{"title":"Effects of exercise on mental health in mice with circadian rhythm disruption.","authors":"Chunxiao He, Masahiro Wakayama, Hanlin Jiang, Tingrui Zhao, Yifan Zhang, Bin Liu, Hideki Moriyama","doi":"10.1016/j.jad.2025.119936","DOIUrl":"10.1016/j.jad.2025.119936","url":null,"abstract":"<p><strong>Background: </strong>Circadian rhythm disruptions are major contributors to anxiety and depression, potentially involving mechanisms like altered clock gene activity and midbrain dopamine system impairments. Exercise has been shown to play a significant role in maintaining the stability of the circadian rhythm and promoting mental health. This study aimed to investigate whether various exercise modes could alleviate mental health issues triggered by circadian rhythm disruption.</p><p><strong>Methods: </strong>A total of 48 male C57BL/6J mice were randomly divided into four groups: control group, circadian rhythm disruption group, aerobic exercise group with circadian rhythm disruption, and resistance exercise group with circadian rhythm disruption. Circadian rhythm disruption was induced by altering the light-dark cycle every three days, followed by four weeks of exercise intervention. The behavioral rhythms of mice were evaluated through sleep recording. Behavioral assessments, including the open field test, elevated plus maze, and forced swim test, were used to evaluate anxiety- and depression-like behaviors. The expression of clock genes and dopamine levels in the prefrontal cortex were analyzed using quantitative real-time PCR and enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Exercise interventions significantly reduced anxiety- and depression-like behaviors in the mice. Aerobic and resistance exercise significantly maintained the circadian rhythmic expression pattern of the Bmal1 gene. Aerobic exercise increased dopamine levels in the prefrontal cortex.</p><p><strong>Conclusion: </strong>Exercise, especially aerobic exercise, effectively alleviates mental health challenges associated with circadian rhythm disruption by influencing clock gene expression and dopamine regulation in the prefrontal cortex. These findings provide evidence for the potential use of exercise interventions as therapeutic strategies for circadian rhythm-related mental health problems.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119936"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A commentary on \"The relationship between unhealthy lifestyle behaviors and depression: Evidence from NHANES\".","authors":"JingYing Ma, FaDan Tang, Jue Hu","doi":"10.1016/j.jad.2025.119903","DOIUrl":"10.1016/j.jad.2025.119903","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119903"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure change patterns during pregnancy and neurodevelopment trajectories in early childhood: A birth cohort study.","authors":"Xinyue Li, Xiuxiu Li, Zijun Yang, Xuemei Liu, Jiayue Zhang, Hualiang Lin, Min Xia, Li Cai, Yanna Zhu, Min Wei, Zilong Zhang, Min Zhang","doi":"10.1016/j.jad.2025.119933","DOIUrl":"10.1016/j.jad.2025.119933","url":null,"abstract":"<p><strong>Background: </strong>The impact of maternal blood pressure (BP) changes during pregnancy on offspring's neurodevelopment has been understudied. We investigated the associations between maternal BP change patterns and neurodevelopmental trajectories in children.</p><p><strong>Methods: </strong>We included 2084 mother-child pairs from an ongoing birth cohort study launched in 2018 in Shenzhen, China. Maternal BPs were repeatedly measured over pregnancy, and children's neurodevelopment status was evaluated regularly within 2 years after birth. We identified BP and neurodevelopmental trajectories using trajectory modeling, followed by multinomial logistic and robust Poisson regressions to estimate associations, adjusting for multiple confounders.</p><p><strong>Results: </strong>We identified three distinct maternal BP change patterns (\"Moderate-stable\", \"Low-increasing\" and \"High-decreasing\") and three trajectories for global neurodevelopment in children (\"High\", \"Moderate\" and \"Low\"). Compared with children whose mothers in the \"Moderate-stable\" group, those with mothers in the \"High-decreasing\" group were more likely to have slower neurodevelopment [adjusted odds ratio (aOR): 1.397 (95 % CI: 0.998-1.957) for \"Low\" vs \"Moderate\"; 1.593 (95 % CI: 1.068-2.375) for \"Low\" vs \"High\"]. Children with mothers in the \"Low-increasing\" group also had increased risks of delayed neurodevelopment [aOR: 1.357 (95 % CI: 1.014-1.818) for \"Low\" vs \"Moderate\"; 1.416 (95 % CI: 1.005-1.994) for \"Low\" vs \"High\"]. Consistent results were found in domain-specific analyses as children whose mothers had \"Moderate-stable\" BP change patterns generally had better neurodevelopment.</p><p><strong>Conclusions: </strong>We found that a moderate and stable maternal BP during pregnancy was associated with better neurodevelopment in offspring.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119933"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based predictive model for postpartum post-traumatic stress disorder: A prospective cohort study.","authors":"Jingfen Chen, Shu Wang, Xiaolu Lai, Linli Zou, Shi Wu Wen, Daniel Krewski, Yang Zhao, Lili Zhang, Ri-Hua Xie","doi":"10.1016/j.jad.2025.119935","DOIUrl":"10.1016/j.jad.2025.119935","url":null,"abstract":"<p><strong>Background: </strong>Postpartum Post-Traumatic Stress Disorder (PTSD) is a public health issue affecting both mothers and infants. Early identification of high-risk women for PTSD could mitigate its impacts. This study aimed to develop and validate a machine learning (ML)-based model for predicting PTSD risk in the early postpartum period.</p><p><strong>Methods: </strong>A prospective cohort study collected sociodemographic and clinical, adverse childhood experiences, and biochemical data at 3 days postpartum, with PTSD symptoms assessed at 42 days postpartum. Five ML models were developed using Logistic Regression (LR), Decision Tree, Random Forest, Support Vector Machine, and eXtreme Gradient Boosting. Model performance was assessed using discrimination, calibration, and clinical application in an independent validation cohort, with Area Under the Receiver Operating Characteristic Curves (AUC). The best-performing model was deployed as a web application.</p><p><strong>Results: </strong>A total of 900 postpartum women were included in model development and 300 in the validation cohort. AUCs for the five models ranged from 0.768 to 0.850, with the LR model performing best (AUC of 0.850; 95%CI: 0.776-0.923). The LR model achieved a Brier score of 0.069, sensitivity of 0.844, specificity of 0.724, and F1 score of 0.406. A web-based calculator incorporating 8 predictors was developed for clinical use.</p><p><strong>Conclusion: </strong>This study demonstrates the effectiveness of a ML-based model in predicting postpartum PTSD risk. The developed web-based risk calculator enables early identification of high-risk women, supporting timely and targeted interventions. These findings highlight the potential of ML tools to improve maternal mental health care, though further calibration in independent and diverse cohorts is needed.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119935"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between perinatal maternal mental health during the COVID-19 pandemic and offspring neurodevelopment at 24 months of age","authors":"Anna Sindalovsky ,&nbsp;Katherine Geisler ,&nbsp;Heather G. Huddleston ,&nbsp;Marcelle I. Cedars ,&nbsp;Eleni G. Jaswa ,&nbsp;Riley Huddleston ,&nbsp;Maya Julian-Kwong ,&nbsp;Jamie Corley ,&nbsp;Elena Hoskin ,&nbsp;Karla J. Lindquist","doi":"10.1016/j.jad.2025.119884","DOIUrl":"10.1016/j.jad.2025.119884","url":null,"abstract":"<div><h3>Background</h3><div>Prenatal anxiety and depression have been linked to adverse childhood neurodevelopment, potentially through cortisol-induced epigenetic changes. Postpartum depression is also associated with neurodevelopmental delays, possibly via altered parental attachment. While prenatal and postpartum mental health may be correlated, their relative and independent impacts on offspring neurodevelopment remain unclear. This study examines the effects of prenatal and postpartum anxiety and/or depression on neurodevelopmental delay at 24 months.</div></div><div><h3>Methods</h3><div>In a nationwide prospective cohort from the “Assessing the Safety of Pregnancy in the Coronavirus Pandemic” study, prenatal anxiety (GAD-7), prenatal depression (PHQ-9), and six-week postpartum depression (EPDS) were assessed. Childhood neurodevelopment was measured using the Ages and Stages Questionnaire, 3rd edition (ASQ-3). Logistic regression tested associations between moderate-to-severe maternal anxiety/depression and neurodevelopmental delay, adjusting for participant age, education, household income, and residential density. Alcohol, nicotine, anxiety/depression medication use during pregnancy, and preterm birth were considered as moderators/mediators.</div></div><div><h3>Results</h3><div>Offspring of participants experiencing both prenatal and postpartum moderate-to-severe anxiety or depression (<em>N</em> = 62) had a higher risk of neurodevelopmental delay at 24 months compared to those who experienced neither (<em>N</em> = 1060) with an adjusted risk ratio of 1.88 (<em>p</em> &lt; 0.001). While delay risk was higher in offspring of those with only prenatal (<em>N</em> = 218) or postpartum (<em>N</em> = 45) anxiety/depression, these were not statistically significant.</div></div><div><h3>Conclusion</h3><div>Having both moderate-to-severe prenatal and postpartum anxiety or depression independently increased the risk of developmental delay at 24 months, even after adjusting for confounders. Further research is needed to explore underlying mechanisms linking maternal mental health and fetal neurodevelopment.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119884"},"PeriodicalIF":4.9,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prebiotics chronotherapy alleviates depression-like behaviors in FMT mice through enhancing short-chain fatty acids receptors and intestinal barrier.","authors":"Yuhao Li, Shuo Zhang, Chuying Li, Jinlin Shen, Pengpeng Cao, Yanzhuang Sun, Xiuyun Ma, Bei An","doi":"10.1016/j.jad.2025.119885","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119885","url":null,"abstract":"<p><strong>Background: </strong>Prebiotics interventions to restore microbiome homeostasis may have long-lasting benefits for mental health especially in adolescence. However, the anti-depressants of prebiotics, particularly in prebiotics chronotherapy, orchestrated remain unknown. We aimed to elucidate the underlying mechanisms of prebiotics in light of maximum antidepressant effects by appropriate dosing timing.</p><p><strong>Methods: </strong>Adolescent depression mouse model was made by fecal microbiota transplantation (FMT) from major depressive disorder (MDD) adolescent patients. Sodium Butyrate (SB), one of SCFAs, was intragastrically administrated to mice at Zeitgeber time 4 (ZT4: the highest short-chain fatty acids (SCFAs) receptor-activated timing) or ZT16 (the lowest SCFA receptor-activated timing) for the last 2 weeks within 4-week-FMT exposure. The success of modeling and antidepressant effects of SB chronotherapy were determined by changes in depression-like behaviors, inflammation, neurotrophy, neuron functions, circadian rhythm, and barrier systems.</p><p><strong>Results: </strong>SB alleviated depressive symptoms at ZT4 with better efficacy over ZT16. SB decreased inflammation, upregulated neurotrophy, restored functions, and re-established circadian rhythm. Notably, SB increased the expressions of SCFAs receptors to repair the intestinal barrier and blood-brain barrier, thereby alleviating depressive symptoms.</p><p><strong>Limitation: </strong>Only one prebiotic with one disease was involved.</p><p><strong>Conclusion: </strong>SB supplementation could be a promising therapeutic tactic for restoring the integrity of barrier systems by enhancing the intestinal SCFAs receptors. Alignment SB supplementation with circadian clocks might help to obtain better antidepressant efficacy, which may generate novel insights into diseases related to diseases with barrier system impairment and optimize interventions to improve health and human well-being.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119885"},"PeriodicalIF":4.9,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The roles of attachment and social support in post-traumatic stress among refugees and asylum seekers.","authors":"Jennifer Kurath, Lisa Dasen, Nina Philipp, Julia Spaaij, Béatrice Strock, Matthis Schick, Richard A Bryant, Naser Morina","doi":"10.1016/j.jad.2025.119887","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119887","url":null,"abstract":"<p><strong>Background: </strong>Refugees and asylum seekers (RAS) are often exposed to stressors before, during, and after migration, with trauma and post-migration living difficulties (PMLD) frequently associated with elevated post-traumatic stress (PTS). Preliminary studies suggest that attachment insecurity plays a role in the link between PMLD and PTS in RAS. However, the mechanisms by which attachment insecurity mediates PTS are not well understood. Perceived social support may represent a key psychological pathway through which attachment insecurity impacts PTS.</p><p><strong>Objectives: </strong>This study investigated 1) whether attachment insecurity (i.e. anxious and avoidant attachment) mediates the association between stressors (i.e., trauma exposure, PMLD) and PTS, and 2) whether perceived social support further mediates the relationship between attachment insecurity and PTS.</p><p><strong>Methods: </strong>The sample comprised 407 RAS (54.0 % male; mean age 33.7 years) from eight different regions in Switzerland. Participants responded to questionnaires assessing trauma exposure, PMLD, attachment insecurity, perceived social support, and PTS. Path analysis was used to test two models: 1) a mediation model (i.e., model 1) with attachment anxiety and avoidance as mediators between stressors (i.e., trauma, PMLD) and PTS, and 2) model 1 with perceived social support as an additional mediator between attachment insecurity and PTS.</p><p><strong>Results: </strong>Attachment anxiety and avoidance mediated the association between PMLD and PTS, but not between trauma and PTS. Perceived social support did not improve explained variance in PTS.</p><p><strong>Conclusions: </strong>Attachment is an important psychological mechanism when studying traumatised RAS who experience substantial PMLD. The role of perceived social support needs to be further investigated.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119887"},"PeriodicalIF":4.9,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of antidepressant augmentation with amantadine vs pramipexole in treatment-resistant unipolar depression: A randomised controlled trial.","authors":"Biswa Ranjan Mishra, Debadatta Mohapatra, Tathagata Biswas, Archana Mishra, Sahadeb Panigrahi, Rituparna Maiti","doi":"10.1016/j.jad.2025.119891","DOIUrl":"10.1016/j.jad.2025.119891","url":null,"abstract":"<p><strong>Background: </strong>Augmentation strategies for treatment-resistant depression (TRD) are limited, with strongest evidence for atypical antipsychotics. Given emerging insights into the neurobiology of TRD, new drug classes merit investigation. We hypothesised that augmentation with amantadine (NMDA antagonist) and pramipexole (dopamine agonist) would show comparable efficacy and safety to quetiapine in TRD.</p><p><strong>Methods: </strong>In this open-label trial, 150 patients with TRD were equally randomised to receive amantadine 200 mg/day, pramipexole 37.5 mg/day, or quetiapine 100 mg/day, as augmentation to ongoing sertraline. The Hamilton Depression Rating Scale (HAM-D21) and Clinical Global Impression (CGI)-Severity and CGI-Improvement scales were assessed and compared within and between the groups at baseline, four, and eight weeks. Serum Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) were measured at baseline, four and eight weeks to evaluate and compare neurotrophic changes between the groups alongside clinical response.</p><p><strong>Results: </strong>Mixed-model ANOVA revealed significant HAM-D and CGI-S reductions in all three groups over eight weeks (p < 0.001). Between-group analysis revealed pramipexole was significantly better compared to both amantadine and quetiapine on all clinical measures at weeks four and eight (p < 0.001). Amantadine and quetiapine showed comparable efficacy (p > 0.05). BDNF and NGF levels increased significantly within each group (p < 0.001), but between-group differences were non-significant (p > 0.05). The three groups reported similar occurence of adverse events (p = 0.184).</p><p><strong>Conclusion: </strong>Augmentation with amantadine and pramipexole were safe and effective in TRD. Additionally, pramipexole showed better efficacy to amantadine and quetiapine. Clinical improvements corroborated with improved BDNF and NGF levels. However, larger multi-centric studies are warranted for generalisability. (ClinicalTrials.gov: NCT04936126).</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119891"},"PeriodicalIF":4.9,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resilience and childhood trauma in mood disorders: Psychopathological implications and treatment response","authors":"Giovanni Camardese ,&nbsp;Antonio Maria D'Onofrio ,&nbsp;Francesca Bardi ,&nbsp;Alessio Simonetti ,&nbsp;Alexia Koukopoulos ,&nbsp;Delfina Janiri ,&nbsp;Lorenzo Moccia ,&nbsp;Marianna Mazza ,&nbsp;Mauro Pettorruso ,&nbsp;Giovanni Martinotti ,&nbsp;Gabriele Sani","doi":"10.1016/j.jad.2025.119918","DOIUrl":"10.1016/j.jad.2025.119918","url":null,"abstract":"<div><h3>Background and aim</h3><div>Childhood trauma is a key risk factor for mood disorders and is associated with greater clinical severity, while resilience may act as a protective factor. This study investigates how childhood trauma and resilience interact to shape psychopathology and treatment response in patients with major depressive disorder (MDD) and bipolar disorder (BD).</div></div><div><h3>Methods</h3><div>The study included 669 participants: 569 patients (380 MDD, 189 BD) and 100 healthy controls (HC). Symptom severity was assessed using standardized scales, with follow-up evaluations of depressive symptoms at six months. All participants completed the Childhood Trauma Questionnaire (CTQ) and Connor-Davidson Resilience Scale (CD-RISC).</div></div><div><h3>Results</h3><div>Patients showed lower resilience and higher childhood trauma scores than HC (both <em>p</em> &lt; 0.001), with more marked differences in those with depressive or anxiety symptoms (<em>p</em> &lt; 0.05). In MDD, low resilience was linked to anhedonia, psychomotor retardation, general psychopathology, suicidality, and non-remission (all <em>p</em> ≤ 0.001), while in BD, it was associated with depressive and anxiety severity and anhedonia (all <em>p</em> ≤ 0.01). Childhood trauma was unrelated to most outcomes, except for higher scores in suicidal MDD patients (<em>p</em> = 0.010), and showed an inverse correlation with resilience in MDD and HC. Linear regression showed that gender (<em>p</em> = 0.013) and anhedonia (<em>p</em> = 0.005) significantly predicted resilience. Logistic regression revealed that higher resilience predicted remission (<em>p</em> = 0.012).</div></div><div><h3>Conclusions</h3><div>Resilience and childhood trauma influence clinical severity in mood disorders. Resilience emerged as a protective factor and predictor of remission, supporting its role as a therapeutic target.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119918"},"PeriodicalIF":4.9,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal network structures in PTSD treatment outcomes: Implications for tailored treatment","authors":"Bingyu Xu ,&nbsp;Soyeong Kim ,&nbsp;Qiyue Cai ,&nbsp;Emily J. Lubin ,&nbsp;Sydni A.J. Basha ,&nbsp;Rebecca K. Blais ,&nbsp;Kaloyan S. Tanev","doi":"10.1016/j.jad.2025.119917","DOIUrl":"10.1016/j.jad.2025.119917","url":null,"abstract":"<div><div>Post-traumatic Stress Disorder (PTSD) is a debilitating condition disproportionately affecting military populations. Despite wide-spread availability of trauma-focused treatments like Cognitive Processing Therapy (CPT) and Prolonged Exposure Therapy (PE), many patients continue to experience PTSD symptoms post-treatment. This study employed network analyses to investigate variations in PTSD symptom networks between treatment responders and non-responders. The sample comprised 1902 service members and veterans who completed a two-week intensive PTSD treatment program (CPT or PE). The PTSD Checklist for DSM-5 assessed baseline and post-treatment PTSD severity. Most participants were male (80.27 %), White (76.17 %), veterans (76.37 %), and previously deployed (90.13 %). We compared networks across groups at baseline and within groups over treatment. Participants reported significant declines in PTSD severity over time (<em>t</em>[11901] = 1238.13, <em>p</em> &lt; 0.001), with 28.23 % (<em>n</em> = 537) classified as responders based on a reliable change index. Responders had significantly higher baseline PTSD severity than non-responders (<em>t</em>([11,393.9] = −14.29, <em>p</em> &lt; 0.001). Network comparison tests revealed a higher global strength among non-responders at baseline. Network structure and connectivity remained stable from baseline to post-treatment, suggesting limited reorganization of symptom relationships during the initial two-week treatment phase. Slope analysis revealed lower network connectivity among responders, indicating a loosening symptom interrelations potentially linked to greater symptom independence or reduced mutual reinforcement. A reduction in global strength and significant structural differences were identified between post-treatment and 12-month follow-up networks. Reductions in central symptoms identified in slope network might serve a key role in monitoring treatment response. Follow-up network revealed structural changes that might reflect skill application after treatment.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119917"},"PeriodicalIF":4.9,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}