Journal of affective disorders最新文献

{"title":"Alcohol use across trials of psychological interventions for bipolar: A systematic review and meta-analysis","authors":"Lauren Halsall ,&nbsp;Steven Jones ,&nbsp;Zoe Swithenbank ,&nbsp;Anastasia Ushakova ,&nbsp;Laura Goodwin","doi":"10.1016/j.jad.2025.119745","DOIUrl":"10.1016/j.jad.2025.119745","url":null,"abstract":"<div><h3>Background</h3><div>Clinical guidelines recommend psychological interventions for bipolar disorder (BD). However, although BD commonly co-occurs with alcohol use disorder (AUD), it is not established how frequently individuals with AUD are excluded from BD psychological intervention trials, or whether this exclusion impacts trial efficacy. Consequently, it is unclear whether evidenced-based treatment decisions can be made for this population.</div></div><div><h3>Methods</h3><div>A systematic review of RCTs of psychological interventions for BD (PROSPERO ref: CRD42023474548) was conducted to explore the proportion of trials i) reporting alcohol-related exclusion criterion, and/or ii) measuring alcohol use at follow-up. Random effects meta-analyses with sub-group comparisons were also conducted, to investigate whether intervention efficacy differed between trials including and excluding individuals with an AUD.</div></div><div><h3>Results</h3><div>Across the 92 trials identified, 31 (33.7%) reported alcohol-related exclusion, and only 3 (3.3%) measured alcohol use at follow-up. The pooled effect sizes for depressive or manic symptoms did not significantly differ between trials including or excluding individuals with co-occurring AUD across the main analyses, although these may be sensitive to methodological changes. Certainty of evidence was moderate.</div></div><div><h3>Conclusions</h3><div>Overall, findings indicate that alcohol-related exclusion is common across trials of psychological interventions, but that intervention efficacy does not significantly differ between trials including and excluding individuals with AUD. Consequently, it is recommended that intervention studies do not exclude people with AUD, in order for evidenced-based treatment to be evaluated in those with co-occurring problems.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119745"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between regional prescriptions of lithium and clozapine and suicide mortality in children and adolescents in France between 2014 and 2019","authors":"Edouard Guez ,&nbsp;Alejandro Rojas-Chaves ,&nbsp;Judith Van Der Waerden ,&nbsp;Maria Melchior ,&nbsp;Hugues Pellerin ,&nbsp;Angèle Consoli ,&nbsp;David Cohen ,&nbsp;Xavier Benarous","doi":"10.1016/j.jad.2025.119738","DOIUrl":"10.1016/j.jad.2025.119738","url":null,"abstract":"<div><h3>Introduction</h3><div>The protective effect of lithium and clozapine against suicide risk was reported in adults but remains unclear in the pediatric population.</div></div><div><h3>Method</h3><div>This cross-sectional ecological study utilized a combination of health registers to collect information on drug prescriptions (OPENMEDIC national health insurance database), mortality (CepiDC national mortality register), medical demography (CNOM data) and social disadvantage (INSEE data), extracting data on subjects aged 0 to 19 years living in France from 2014 to 2019. The relationships between the regional variabilities in lithium and clozapine dispensations and different death rates: by suicide and self-injury, by mental and behavioral disorders, and all causes.</div></div><div><h3>Results</h3><div>Dispensations of lithium and clozapine varied widely by region. Inter-regional variabilities in lithium and clozapine dispensations were associated with mortality by suicide and self-injury in simple regression models (respectively, <em>β</em> = −0.006, <em>p</em> = .032 and <em>β</em> − 0.0104, <em>p</em> = .009) but not for other causes of mortality. Both dispensations were strongly correlated with social deprivation scores and the density of adult psychiatrists. In robust and multiple regression models, the level of association with suicide and self-injury mortality remained significant for clozapine but not for lithium.</div></div><div><h3>Discussion</h3><div>Keeping in mind the limitations inherent to spatial study design, these preliminary findings are consistent with a possible antisuicide effect of clozapine in the pediatric population, while the effect of lithium is less clear. Even in the context of the French free-of-charge healthcare system, major spatial inequities exist in access to these medications for youths, partly underlaid by social disparities and medical demography.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119738"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting symptom worsening in remitted depression on maintenance pharmacotherapy using digital biomarkers: A prognostic modeling study using machine learning","authors":"Ryo Kiguchi ,&nbsp;Ayano Hata ,&nbsp;Satoki Fujita ,&nbsp;Yuki Yoshida ,&nbsp;Yoshitake Kitanishi ,&nbsp;Junichiro Yoshimoto ,&nbsp;Aran Tajika ,&nbsp;Toshi A. Furukawa","doi":"10.1016/j.jad.2025.119703","DOIUrl":"10.1016/j.jad.2025.119703","url":null,"abstract":"<div><h3>Background</h3><div>Depression is highly recurrent, and predicting relapses in a timely manner is critical. We applied machine learning to predict the worsening of depressive symptoms.</div></div><div><h3>Methods</h3><div>We conducted a 52-week cohort study of patients with recurrent depression on maintenance pharmacotherapy, using a smartphone app and a wearable device. Participants reported their depression level by filling in the Kessler Psychological Distress Scale (K6) every week on the app. We first classified participants based on their lifestyle characteristics. We then applied the leave-one-participant-out cross-validated (LOOCV) XGBoost to predict K6 scores. We also simulated how the model can perform, where the data of a new patient is collected for some time and then added to the existing dataset to predict the new patient's symptom worsening in the future.</div></div><div><h3>Results</h3><div>We analyzed the data from 89 participants (49 males; median age, 44 years). We identified two distinct clusters of participants: participants in Cluster 1 had unstable sleep patterns and spent more time indoors, whereas those in Cluster 2 spent more time working/studying. The straightforward LOOCV performance showed good AUC but low kappa. When we added observations of a new patient for three months, the weighted kappa between the predicted and the observed K6 classes improved to 0.68 (95 % confidence interval: 0.55–0.81) for Cluster 1 and 0.59 (0.48–0.70) for Cluster 2.</div></div><div><h3>Conclusions</h3><div>Subtyping patients by their behavioral patterns and applying machine learning allowed us to build prediction models for depression relapses among patients on maintenance pharmacotherapy.</div></div><div><h3>Funding</h3><div>Shionogi &amp; Co., Ltd.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119703"},"PeriodicalIF":4.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Various forms of pregnancy losses and risks of depression and anxiety in later life","authors":"Ying Hu ,&nbsp;Xuan Wang ,&nbsp;Shuqi Zhu ,&nbsp;Danqing Chen ,&nbsp;Hao Ma ,&nbsp;Zhaoxia Liang","doi":"10.1016/j.jad.2025.119728","DOIUrl":"10.1016/j.jad.2025.119728","url":null,"abstract":"<div><h3>Background</h3><div>The long-term associations between various forms of pregnancy losses (spontaneous miscarriage, stillbirth, and induced abortion) and risks of depression and anxiety in later life remains unclear.</div></div><div><h3>Objective</h3><div>We prospectively investigated the long-term associations of spontaneous miscarriage, stillbirth, and induced abortion with the risks of depression and anxiety.</div></div><div><h3>Study design</h3><div>A total of 175,614 participants with pregnancy history and free of depression or anxiety at baseline from the UK Biobank were included. Cox proportional hazard models were used to evaluate the associations between various forms of pregnancy losses and risks of depression and anxiety.</div></div><div><h3>Results</h3><div>During a median follow-up of 12.3 years, 4806 depression incidents and 5601 anxiety incidents were documented. After adjustment for reproductive factors, lifestyle factors, social support factors, and other covariates, various forms of pregnancy losses had differential associations with the risks of depression and anxiety. Induced abortion showed the strongest association with depression and anxiety risk; followed by spontaneous miscarriage. For example, each additional induced abortion was significantly associated with a 12 % higher risk of anxiety (HRs, 95 % CI, 1.12, 1.06–1.18), whereas each additional spontaneous abortion was associated with only a 4 % higher risk of anxiety (HRs, 95 % CI, 1.04, 1.00–1.07).Stillbirth was not associated with a higher risk of depression or anxiety. Moreover, we found that the association between induced abortion and risk of depression was more pronounced in parous women than nulliparous women (<em>P</em>-interaction = 0.013).</div></div><div><h3>Conclusions</h3><div>Spontaneous miscarriage, stillbirth, and induced abortion are differently associated with risks of depression and anxiety.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119728"},"PeriodicalIF":4.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study on the relationship between cardiorespiratory fitness, inhibitory control, and event-related potentials moderated by severity of symptoms in patients with major depressive disorder.","authors":"Nils H Pixa, Stephanie Fröhlich, Tim Göcking, Lothar Thorwesten, Sarah E Fromme, Bernhard T Baune, Claudia Voelcker-Rehage","doi":"10.1016/j.jad.2025.119701","DOIUrl":"10.1016/j.jad.2025.119701","url":null,"abstract":"<p><strong>Background: </strong>Depression affects around 280 million people globally, with a lifetime prevalence of 20% for Major Depressive Disorder (MDD). Core MDD symptoms are impaired executive functions (EF), such as inhibitory cognitive control. Higher cardiorespiratory fitness (CRF) is linked to improved cognitive function, but whether this also applies to MDD patients remains unclear.</p><p><strong>Methods: </strong>This study examined the relationship between CRF and inhibitory control in 66 MDD patients (33 females, aged 18-63). Participants underwent VO2max testing after completing a flanker task while event-related potentials (ERPs) (N1, N2, P3) were assessed. Hierarchical multiple linear regressions were used to analyze the influence of CRF on flanker performance and ERP components, controlling for MDD severity, negative affect, and demographic variables.</p><p><strong>Results: </strong>CRF explained 15% of the variance in flanker performance (∆R² = 0.15, p < .001), with the final model (including all variables) explaining 47 %. This positive effect of CRF was independent of MDD severity. Concerning the ERP correlates, CRF showed a medium effect on N1 latency at O1 (β = -0.32, p = .04, ∆R² = 0.07, p = .04) with shorter latency in fitter individuals.</p><p><strong>Limitations: </strong>The study's cross-sectional design and moderate sample size limits causal inference.</p><p><strong>Conclusions: </strong>CRF was positively related to inhibitory cognitive control in MDD patients, independent of symptom severity, suggesting cognitive benefits. Earlier N1-peaks in fitter individuals suggest potential higher neural efficiency. Limited associations with ERP components indicate complex neural mechanisms, warranting further research. MDD treatments integrating physical exercise could contribute to improving cognitive health and mitigate decline.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119701"},"PeriodicalIF":4.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Epidemiology and effect of psychiatric comorbidities on survival rates in patients with systemic sclerosis: A nationwide population-based cohort study” [J. Affect. Disord. 382 (2025) 518–524 / JAFD-D-24-04324R1]","authors":"Yao-Tung Lee ,&nbsp;Fang-Yi Wu ,&nbsp;Yu-Sheng Chang","doi":"10.1016/j.jad.2025.119384","DOIUrl":"10.1016/j.jad.2025.119384","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119384"},"PeriodicalIF":4.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroticism, omega-3 fatty acids, and risk of incident dementia","authors":"Yaqing Gao,&nbsp;Cornelia van Duijn,&nbsp;Thomas J. Littlejohns ,&nbsp;Najaf Amin","doi":"10.1016/j.jad.2025.119733","DOIUrl":"10.1016/j.jad.2025.119733","url":null,"abstract":"<div><h3>Background</h3><div>High levels of neuroticism are associated with an increased risk of dementia, yet the underlying biological mechanisms remain poorly understood. Investigating the role of metabolites, the downstream products of metabolic processes, may offer valuable insights into this association.</div></div><div><h3>Methods</h3><div>In 215,624 dementia-free UK Biobank participants aged 40–69 years, we assessed neuroticism's associations with 249 nuclear magnetic resonance-measured metabolites using linear regression. Metabolites reaching Bonferroni-corrected significance were further tested for associations with incident all-cause dementia, Alzheimer's disease (AD) and vascular dementia (VaD) using Cox proportional-hazards regression, and with white matter hyperintensities volume using linear regression. Causality in significant observational relationships was evaluated through two-sample Mendelian randomization.</div></div><div><h3>Results</h3><div>Neuroticism was significantly associated with 119 out of 249 metabolites (Bonferroni-adjusted <em>p</em> &lt; 0.05). Among these, five metabolites involved in fatty acid metabolism showed consistent directional associations with both neuroticism and incident all-cause dementia. Specifically, four metabolites, including docosahexaenoic acid (DHA), DHA% of total fatty acids, omega-3 % of total fatty acids, and degree of unsaturation, were associated with lower neuroticism levels and a decreased risk of incident dementia. Conversely, the omega-6/omega-3 ratio was positively associated with both neuroticism and dementia risk. Associations between these five metabolites and VaD were stronger than those with AD. Mendelian randomization analysis suggested that high levels of neuroticism reduce DHA levels, which, in turn, contribute to white matter pathology, a hallmark of VaD.</div></div><div><h3>Conclusions</h3><div>Neuroticism is associated with lower levels of omega-3 fatty acids, particularly DHA, which may increase dementia risk, primarily through cerebrovascular mechanisms.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119733"},"PeriodicalIF":4.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of negative urgency and sustained attention: Evidence from the late positive potential","authors":"David H. Johnson ,&nbsp;Sarah H. Sperry ,&nbsp;Alexis M. Berry ,&nbsp;Daniela Porro ,&nbsp;Brian J. Albanese","doi":"10.1016/j.jad.2025.119699","DOIUrl":"10.1016/j.jad.2025.119699","url":null,"abstract":"<div><div>Urgency reflects the tendency to act rashly in the face of intense emotion and has been associated with a host of maladaptive outcomes spanning psychopathology domains, including substance use, anxiety-related disorders, and suicide risk. Despite the impairment associated with urgency, work seeking to understand the neural mechanisms of this cognitive-affective risk factor has yielded inconsistent results, suggesting the need for new approaches to understand why some individuals are more likely to engage in impulsive behaviors in the context of positive and negative emotions. One possible mechanism is sustained attention on emotional information, measured by the late positive potential (LPP), an event-related potential (ERP) component that indexes sustained attention toward motivationally significant and emotional stimuli. The present study aimed to elucidate the relations between sustained attention to emotional images and self-reported urgency. Community adults (<em>n</em> = 62) were recruited based on their report of either elevated suicide risk factors or no history/presence of suicide risk (health controls) and asked to complete an emotional interrupt task in which they viewed distracting, task-irrelevant negative, positive, and neutral images while responding to shapes on the screen. Results indicated that greater negative urgency was significantly associated with heightened sustained attention to threatening stimuli even when controlling for sex, negative affect, and difficulties in emotion regulation. However, more research is needed to replicate this finding, extend this work toward more granular assessments of momentary negative urgency, and to understand how other constructs such as emotion dysregulation moderate the effect of negative urgency on sustained attention.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119699"},"PeriodicalIF":4.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, risk factors and family dynamics of antenatal depression in couples: A multicenter cross-sectional study","authors":"Chengli Tang ,&nbsp;Mengru Wu ,&nbsp;Rui Wu ,&nbsp;Wenjing Qiang ,&nbsp;Yongkang Liu ,&nbsp;Yuan Liu ,&nbsp;Houlin Zhang ,&nbsp;Yifan Wang ,&nbsp;Beibei Zhu ,&nbsp;Fangbiao Tao","doi":"10.1016/j.jad.2025.119702","DOIUrl":"10.1016/j.jad.2025.119702","url":null,"abstract":"<div><h3>Background</h3><div>Parental depression during the perinatal period is a public health concern. This study aims to evaluate the prevalence of antenatal depression in couples, identify associated risk factors, and examine family dynamics, particularly marital and in-law relationships.</div></div><div><h3>Methods</h3><div>A cross-sectional, multicenter study conducted from November 2023 to June 2024 surveyed 2460 pregnant women and their partners in Anhui Province, China. The Edinburgh Postnatal Depression Scale (EPDS) was used for psychological assessment. Logistic regression identified risk factors for antenatal depression, and structural equation modeling (SEM) examined the direct and indirect effects of family relationships on antenatal depression.</div></div><div><h3>Results</h3><div>The prevalence of comorbid antenatal depression within couples was 3.3 %, with similar rates in women (16.4 %) and men (14.6 %). Key risk factors for both maternal and paternal depression included marital distress, unexpected pregnancy, a personal history of depression, and partner depressive symptoms. Additional risk factors for women were mother-in-law relationships, lower education, and lower household income. SEM analysis revealed that mother-in-law relationships had a direct effect on both marital distress (β = 0.69, p &lt; 0.001) and depression in women (β = 0.15, p &lt; 0.001). Furthermore, the indirect effect of mother-in-law relationships on maternal depression (β = 0.12, p &lt; 0.001) was significantly stronger than that on paternal depression (β = 0.02, p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Maternal and paternal mental health during the perinatal period should be prioritized, especially in the presence of marital and in-law stressors. A family-centered care model with targeted psychological support may help mitigate antenatal depression.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119702"},"PeriodicalIF":4.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroconvulsive therapy in adolescents and adults with depression: Effects, cognitive function and related influencing factors.","authors":"Yahui Yang, Kaichao Chen, Kaiwen Liang, Jiamei Guo, Lian Du","doi":"10.1016/j.jad.2025.119700","DOIUrl":"10.1016/j.jad.2025.119700","url":null,"abstract":"<p><strong>Background: </strong>Electroconvulsive therapy (ECT) is an effective and safe treatment for depression, but its efficacy and cognitive effects in adolescents remain unclear. This study compares the effects of a standardized ECT protocol on adolescent and adult depression patients and analyzes influencing factors.</p><p><strong>Methods: </strong>A total of 206 patients with major depressive disorder receiving combined antidepressant and ECT treatment were enrolled in this observational study. Depressive symptom severity and cognitive function were assessed by the HAMD and MoCA, respectively. Covariates were adjusted for using analysis of covariance.</p><p><strong>Results: </strong>A total of 130 adolescents and 76 adults were enrolled. After adjusting for covariates, the effective rate for adults was 86.5 %, significantly higher than the 65 % observed in adolescents (p < 0.01). Similarly, the remission rate for adults was 45.6 %, compared to 28.1 % in adolescents (p < 0.05). Regression analysis revealed that the number of hospitalizations (p < 0.01), baseline psychotic symptoms (p < 0.01), and MoCA cognitive-language scores (p < 0.05) were predictive factors for ECT efficacy in adolescent depression patients. Moreover, ECT was associated with improvements in attention, but declines were observed in overall cognitive function, language ability, and delayed memory. Additionally, after treatment of ECT, adolescent depression showed a significant improvement trend in MoCA naming function, whereas adult patients exhibited a significant deterioration (p < 0.05).</p><p><strong>Conclusion: </strong>ECT was associated with alleviation of depressive symptoms and improvement in attention, but a trend of decline in overall cognitive function was also observed. Moreover, ECT appears more effective in adults than adolescents.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119700"},"PeriodicalIF":4.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}