The relationship between changes in white matter microstructure and cognition in untreated major depressive disorder.

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-12-01 Epub Date: 2025-08-06 DOI:10.1016/j.jad.2025.120027

Wensheng Chen, Guojun Xie, Caixai Xu, Chunguo Zhang, Jiaquan Liang

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引用次数: 0

Abstract

Background: White matter (WM) microstructural abnormalities and cognitive impairments are commonly observed in depressive disorders. This study aimed to explore the association between WM microstructural alterations and cognitive function in patients with untreated Major Depressive Disorder (UMDD) compared to healthy controls (HCs).

Methods: Sixty-one UMDD patients and sixty-five HCs matched for age, gender, and education underwent diffusion tensor imaging (DTI) using a 3.0 T MRI scanner. Fiber tract-based spatial statistics (TBSS) were applied to analyze WM integrity. Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).

Results: Compared to HCs, UMDD patients exhibited significantly increased axial diffusivity (AD) in the right anterior limb of the internal capsule, splenium of the corpus callosum, right superior longitudinal fasciculus, and body of the corpus callosum. Additionally, mean diffusivity (MD) was elevated in the right superior longitudinal fasciculus. AD values in these regions showed a positive correlation with 24-item Hamilton Rating Scale for Depression (HRSD-24) scores (p ≤ 0.003). MD values in the right superior longitudinal fasciculus were positively correlated with HRSD-24 scores (r = 0.432, p = 0.001) and negatively correlated with RBANS List Learning and Coding scores (p ≤ 0.003).

Conclusion: White matter microstructural abnormalities in UMDD patients are associated with depression severity, suggesting that the underlying structural disruptions are an important indicator of functional abnormalities.

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未经治疗的重度抑郁症患者脑白质微结构变化与认知的关系。

背景：白质（WM）微结构异常和认知障碍在抑郁症中很常见。本研究旨在探讨未经治疗的重度抑郁症（UMDD）患者与健康对照组（hc）相比，WM微结构改变与认知功能之间的关系。方法：61例UMDD患者和65例年龄、性别和教育程度相匹配的hc患者使用3.0 T MRI扫描仪进行弥散张量成像（DTI）。采用基于纤维束的空间统计（TBSS）方法对WM完整性进行分析。认知功能评估采用神经心理状态评估可重复电池（rban）。结果：与hc相比，UMDD患者的右前肢内囊、胼胝体脾、右上纵束和胼胝体体的轴向弥散性（AD）明显增加。此外，右上纵束平均弥漫性（MD）升高。这些地区的AD值与24项汉密尔顿抑郁量表（HRSD-24）得分呈正相关（p ≤ 0.003）。右上纵束MD值与HRSD-24评分呈正相关（r = 0.432,p = 0.001），与RBANS List Learning and Coding评分呈负相关（p ≤ 0.003）。结论：UMDD患者白质微结构异常与抑郁严重程度相关，提示潜在的结构破坏是功能异常的重要指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.