Journal of affective disorders最新文献

{"title":"Identifying embodied risk and protective factors in mothers with postpartum depression and comorbidities using Parental Embodied Mentalizing Assessment™","authors":"Virginia Simon ,&nbsp;Rose Spencer ,&nbsp;Steffen Zitzmann ,&nbsp;Dana Shai ,&nbsp;Frank Vitinius ,&nbsp;Brigitte Ramsauer","doi":"10.1016/j.jad.2025.04.030","DOIUrl":"10.1016/j.jad.2025.04.030","url":null,"abstract":"<div><h3>Background</h3><div>Clinically, postpartum depression (PPD) is frequently diagnosed with maternal comorbid mental disorders (postpartum anxiety, PPA; personality disorders, PDs) in mothers. Its association with impaired Parental Embodied Mentalizing (PEM) remains unclear. This study aims to investigate embodied risk and protective factors of parental mentalizing in PPD-mothers. More risk factors and fewer protective factors were hypothesized as a function of comorbidities.</div></div><div><h3>Method</h3><div>Sixty-eight mothers with infants aged 3–10 months were examined using the Parental Embodied Mentalizing Assessment™ (PEMA™) on a 5-minute videotaped free-play interaction. Six subgroups were compared according to DSM-IV diagnoses: PPD; PPD and PPA; PPD and Borderline PD (BPD); PPD, PPA, and BPD; PPD and other PDs; and PPD, PPA, and other PDs.</div></div><div><h3>Results</h3><div>Overall, variable subgroup differences were observed (<em>d</em> = 0.9–1.09): PPD-mothers demonstrated the highest and PPD-mothers with BPD the lowest protective factors, in particular <em>Sustained Presence</em>. PPD-mothers with PPA and other PDs showed the lowest interactive <em>Repair</em>, and PPD-mothers with other PDs the highest <em>Connectivity</em>. There were no substantial group differences in risk factors. However, PPD-mothers with BPD displayed the highest <em>Teasing</em> and <em>Objectification</em>, i.e., treating the infant as an inanimate object.</div></div><div><h3>Conclusion</h3><div>In the case of PPD, comorbidities must be taken into account, as they primarily impact the protective character of the mother's embodied communication during infancy. Comorbid BPD is associated with fewer protective and more risk factors, whereas comorbid PPA and/or other PDs are associated with increased over-control. Further research is needed to validate the PEMA™ factors, including a non-clinical control group.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 669-679"},"PeriodicalIF":4.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and feasibility of the oxford mental illness suicide tool (OxMIS): A mini-review and meta-analysis","authors":"Gabriele Torino ,&nbsp;Chiara Moltrasio ,&nbsp;Antonio Callari ,&nbsp;Giuseppe Delvecchio","doi":"10.1016/j.jad.2025.04.052","DOIUrl":"10.1016/j.jad.2025.04.052","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with severe mental illness are at a greater risk of suicide than the general population. Therefore, a concerted effort has been made to create increasingly precise and reliable tools over the last decade. Among these tools, in 2019 the Oxford Mental Illness and Suicide Tool (OxMIS) was developed to estimate the probability of suicide risk within 12 months for individuals diagnosed with bipolar disorder or schizophrenia spectrum disorder. Therefore, in this review, we aimed to synthesise the peer-reviewed literature collected on the OxMIS tool.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted using the databases PubMed, PsycINFO, Scopus, and Web of Science, resulting in the identification of 129 records. After removing duplicates and conducting an in-depth review of the full texts, 5 articles were included in the mini-review. Additionally, a fixed-effects model was employed to calculate the pooled effect size from 2 studies using Comprehensive Meta-Analysis (CMA) 3.7 software.</div></div><div><h3>Results</h3><div>The OxMIS tool was found to be clinically feasible and to lead to an average cost-saving of approximately £300 per assessed patient as well as a marginal improvement in quality-adjusted life years. Furthermore, the OxMIS tool achieved good discrimination accuracy in terms of sensitivity and specificity in a Swedish and Finnish validation sample. The overall pooled odd ratio (OR) was 3.416 [95 % CI: 3.092–3.774].</div></div><div><h3>Limitations</h3><div>The first limitation pertains to the scarcity of studies on OxMIS, which necessitates a degree of caution in interpreting the results. Moreover, although the reviewed studies analyzed different aspects of the use of OxMIS, the differences in objectives and research designs limited a comprehensive comparison of the results between the included studies. Finally, the discrepancy in the prevalence of high suicide risk among patients of different study populations requires further investigation in future studies.</div></div><div><h3>Conclusion</h3><div>From the reviewed studies emerged that OxMIS is a novel and promising web-based tool that is capable of estimating the suicide risk of patients with serious mental illnesses. Nevertheless, further external validation studies are required to confirm its clinical utility across different study populations.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 321-328"},"PeriodicalIF":4.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of PTSD-depression comorbidity in long-term mental health sequalae of the October 7th terror attack in Israel: A nationwide prospective study","authors":"Yossi Levi-Belz ,&nbsp;Doron Amsalem ,&nbsp;Yoav Groweiss ,&nbsp;Carmel Blank ,&nbsp;Yuval Neria","doi":"10.1016/j.jad.2025.04.049","DOIUrl":"10.1016/j.jad.2025.04.049","url":null,"abstract":"<div><h3>Introduction</h3><div>The October 7, 2023, attack engendered extensive mental pain and can be considered a mass trauma that affected most Israeli citizens. This study investigates the long-term psychological impact of probable posttraumatic stress disorder and major depressive disorder (PTSD-MDD) one month after October 7th, on anxiety, depression, PTSD, and complex PTSD (CPTSD) symptoms as well as on suicidal ideation, and life satisfaction one-year post-attack among Israeli civilians.</div></div><div><h3>Methods</h3><div>Using a nationally representative cohort of 600 participants (302 women, 50.3 %) aged 18–85 (<em>M</em>_age = 41.02, <em>SD</em> = 13.79), data were collected two months pre-attack (T1), one-month post-attack (T2), and one-year post-attack (T3). Using validated self-report measures, probable diagnostic groups at T2 (no diagnosis, PTSD alone, depression alone, and probable PTSD-MDD comorbidity) were examined as predictors of mental health outcomes at T3, including anxiety, depression, PTSS, CPTSD, suicidal ideation, and life satisfaction. Baseline symptom levels (T1) as well as demographics and trauma-related variables were controlled during the analyses.</div></div><div><h3>Results</h3><div>Probable PTSD-MDD at T2 significantly predicted severe psychological outcomes at T3, including anxiety, depression, PTSS, and suicidal ideation. Life satisfaction was lowest among probable PTSD-MDD participants and highest in those without diagnoses. Notably, probable PTSD-MDD demonstrated greater stability over time compared to single diagnoses, underscoring their persistence. Changes in probable diagnostic categories between T2 and T3 highlighted the dynamic yet challenging recovery trajectories particularly for comorbid conditions.</div></div><div><h3>Discussion</h3><div>The findings underscore the amplifying effect of probable PTSD-MDD comorbidity on psychological distress and reduced life satisfaction. These results underscore the need for integrative, trauma-informed interventions targeting comorbid populations to optimize recovery pathways.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 410-417"},"PeriodicalIF":4.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood socioeconomic position and cognitive aging in Europe: The role of depressive symptoms and loneliness","authors":"Ruixue Huang ,&nbsp;Huiyun Zou ,&nbsp;Zhen Yan ,&nbsp;Weidong Wu ,&nbsp;Lai-Bao Zhuo","doi":"10.1016/j.jad.2025.04.051","DOIUrl":"10.1016/j.jad.2025.04.051","url":null,"abstract":"<div><div>The relationship between childhood socioeconomic position (CSEP) and cognitive decline in later life remains a subject of debate, with no clear consensus. This study aims to examine the impact of CSEP on cognitive decline and the potential mediating effects of depressive symptoms and loneliness. Data were drawn from the Survey of Health, Aging and Retirement in Europe, involving 24,615 participants aged 50–90 years over an 8-year follow-up. CSEP was measured using four indicators at age 10: primary breadwinner's occupational status, overcrowding, housing quality, and the number of books. Cognitive performance, assessed across waves 5–9, included episodic memory (immediate and delayed recall) and executive function (verbal fluency). A linear mixed-effects model was applied to analyze the influence of CSEP on cognitive decline. The results indicated that individuals with disadvantaged CSEP had lower cognitive abilities in later life (intercept_{disadvantaged} = −0.71 for memory, intercept_{disadvantaged} = −1.72 for verbal fluency) and experienced a faster decline in memory (<em>β</em>_{age×disadvantaged} = −0.11), though no significant impact was observed on the rate of executive function decline. Depressive symptoms (<em>β</em>_indirect = −0.02 for memory, <em>β</em>_indirect = −0.05 for verbal fluency) and loneliness (<em>β</em>_indirect = −0.01 for memory, <em>β</em>_indirect = −0.03 for verbal fluency) may partially mediate the link between disadvantaged CSEP and cognitive function. These findings suggest that early-life socioeconomic conditions play a role in cognitive abilities in later life. This evidence deepens public understanding of the mechanisms driving cognitive decline and suggest that strategies to mitigate cognitive aging should be implemented early in life.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 10-16"},"PeriodicalIF":4.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A double-blind, placebo-controlled trial of exenatide for the treatment of olanzapine-related weight gain in obese and overweight adults","authors":"Luis R. Patino,&nbsp;Jeffrey R. Strawn,&nbsp;Caleb M. Adler,&nbsp;Thomas J. Blom,&nbsp;Jeffrey A. Welge,&nbsp;Melissa P. DelBello","doi":"10.1016/j.jad.2025.04.046","DOIUrl":"10.1016/j.jad.2025.04.046","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the safety and efficacy of exenatide in overweight or obese patients treated with olanzapine.</div></div><div><h3>Methods</h3><div>Adults with stable major mood or psychotic disorders were randomized to double-blind exenatide or placebo for 16 weeks. Weight and body mass index (BMI) were monitored throughout the study. A secondary objective was to evaluate the tolerability of exenatide and its effects on mood and psychotic symptoms.</div></div><div><h3>Results</h3><div>A significant difference in weight change was detected between the treatment groups. Participants in the exenatide group experienced on average a minor weight loss, while participants in the placebo group on average experienced weight gain (−0.5 kg [−0.6 %] vs. +2.6 kg [+2.8 %], both <em>p</em> &lt; .01). The most common side effects in the exenatide group were gastrointestinal symptoms and headaches. There were no clinically meaningful differences between the groups in changes to mood or psychotic symptoms.</div></div><div><h3>Conclusions</h3><div>Exenatide is effective and well-tolerated for attenuating olanzapine-associated weight gain.</div></div><div><h3>Clinical trial registration information</h3><div>Exenatide for the Treatment of Weight Gain Associated with Olanzapine in Obese Adults. <span><span>NCT00845507</span><svg><path></path></svg></span></div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 116-122"},"PeriodicalIF":4.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined ketamine and psychotherapy provide no additional benefit beyond ketamine alone in treating depression or PTSD: Evidence from a help-seeking sample","authors":"Tyler M. Moore ,&nbsp;Kathryn Walker ,&nbsp;Emma Tung ,&nbsp;Adam R. Teed ,&nbsp;Franz Hell ,&nbsp;Sivan Kinreich ,&nbsp;Rex Jung ,&nbsp;Fadi Abdel ,&nbsp;Russell W. Hanson ,&nbsp;Shobi S. Ahmed","doi":"10.1016/j.jad.2025.04.041","DOIUrl":"10.1016/j.jad.2025.04.041","url":null,"abstract":"<div><div>Depression and PTSD are prevalent psychiatric conditions that often co-occur and significantly impact quality of life. Ketamine has emerged as a promising rapid-acting treatment for both conditions, while traditional treatments like psychotherapy typically require weeks to show effects. This study investigated whether combining ketamine with psychotherapy produces greater symptom improvement compared to ketamine alone. We analyzed overlapping samples of <em>N</em> = 202, <em>N</em> = 470, and <em>N</em> = 624 help-seeking individuals (all samples ∼60 % female, mean age ∼ 42 years) who received either ketamine alone (KET) or ketamine plus psychotherapy (KET+PSY) across 4–14 treatment sessions within a 30- or 180-day period. Depression symptoms were measured using the PHQ-9, and PTSD symptoms were assessed using the PCL-5. Trajectories of symptom change were analyzed using generalized additive mixed-effects models, controlling for baseline symptoms, demographics, and treatment intervals. Both treatment groups showed substantial improvement in depression and PTSD symptoms, with similar patterns of rapid initial decline followed by stabilization. Contrary to our hypothesis, we found no significant differences in symptom trajectories between the KET and KET+PSY groups. Exploratory analyses revealed non-significant but notable patterns where younger females showed better outcomes with combined treatment, while older males showed better outcomes with ketamine alone. These findings suggest that ketamine's therapeutic effects may be robust enough that additional psychotherapy during the acute treatment phase does not significantly enhance 30-day (and possibly 180-day) outcomes. However, longer-term benefits of combined treatment and potential demographic-specific treatment responses warrant further investigation. These results have important implications for treatment planning and resource allocation in clinical settings.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 233-241"},"PeriodicalIF":4.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cingulate cortex cortical thickness associated with non-suicidal self-injury and suicide risk in youth with mood disorders","authors":"Rebekah S. Huber ,&nbsp;Punitha Subramaniam ,&nbsp;Lauren Heinrich ,&nbsp;Danielle J. Boxer ,&nbsp;Xianfeng Shi ,&nbsp;Mindy Westlund Schreiner ,&nbsp;Perry F. Renshaw ,&nbsp;Deborah A. Yurgelun-Todd ,&nbsp;Douglas G. Kondo","doi":"10.1016/j.jad.2025.04.047","DOIUrl":"10.1016/j.jad.2025.04.047","url":null,"abstract":"<div><h3>Background</h3><div>Non-suicidal self-injury (NSSI) is associated with increased suicide risk and is prevalent among patients with mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD). Structural alterations in cortical regions involved in emotional processing are linked to NSSI as well as suicide risk in mood disorders. Few studies have investigated the neurobiological substrates of NSSI and suicidal thoughts and behaviors (STB), particularly comparing youth with BD to those with MDD. There is a critical need to examine NSSI and STB in the context of MDD and BD separately, as risks differ between these populations.</div></div><div><h3>Methods</h3><div>This study investigated the relationship between anterior cingulate cortex (ACC) cortical thickness and volume and NSSI and STB in youth with mood disorders. One-hundred thirty-seven youth (86 with MDD and 51 with BD), ages 13 to 21, completed a diagnostic interview, clinical assessments, and 3 T magnetic resonance imaging. Morphometric analysis of brain images was performed to evaluate differences in cingulate regions of interest.</div></div><div><h3>Results</h3><div>Seventy-five youth reported a NSSI. Youth with BD were more likely to report NSSI than youth with MDD. In addition, youth with BD and NSSI were more likely to have a suicide attempt and had significantly lower cortical thickness in the right caudal ACC (<em>p</em> = .009, η² = 0.050) compared to youth with MDD and NSSI.</div></div><div><h3>Conclusions</h3><div>These structural alterations in the ACC, which impact emotional regulation and pain processing, may be linked to the increased NSSI and suicide risk observed in BD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged social withdrawal (“hikikomori”) and its associations with depressive symptoms and suicidal ideation among young adults in Korea: Findings from the 2022 Youth Life Survey","authors":"Seong-Uk Baek ,&nbsp;Jin-Ha Yoon","doi":"10.1016/j.jad.2025.04.044","DOIUrl":"10.1016/j.jad.2025.04.044","url":null,"abstract":"<div><h3>Background</h3><div>Hikikomori syndrome (HS) is a public health concern. We investigated the prevalence of HS and its association with depressive symptoms and suicidal ideation among young Korean adults.</div></div><div><h3>Methods</h3><div>Young adults aged 19–34 years was obtained from the 2022 Youth Life Survey, with a total of 14,870 participants. HS was defined as a condition characterized by ≥six months of social withdrawal, including lack of employment or school engagement, lack of social interaction, and confinement to one's home or room, which causes distress to the individual or impairs social functioning. Depressive symptoms were assessed using the Patient Health Questionnaire-9. The presence of suicidal ideation within the past year was evaluated. Logistic regression was performed to calculate odds ratios (ORs) and 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>The prevalence of HS in the sample was 1.4 % (<em>n</em> = 871). Individuals with HS exhibited a higher prevalence of both depressive symptoms (20.9 % vs. 5.9 %) and suicidal ideation (11.0 % vs. 2.3 %) compared to those without HS. The OR (95 % CI) of the association between HS and depressive symptoms was 3.91 (2.47–6.18) compared with non-HS after adjusting for sociodemographic features. Similarly, the adjusted OR (95 % CI) of the association between HS and suicidal ideation was 5.24 (2.88–9.52) compared with non-HS. A further analysis indicated that depressive symptoms partially mediates the association between HS and suicidal ideation.</div></div><div><h3>Limitation</h3><div>The cross-sectional study design limits the ability to infer causality.</div></div><div><h3>Conclusion</h3><div>HS was linked to poor mental health. Policy efforts aimed at identifying young adults with HS and protecting their mental health are required.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal association between stigma and suicidal ideation among patients with major depressive disorder","authors":"Yanzhi Li ,&nbsp;Yan Chen ,&nbsp;Yifeng Liu ,&nbsp;Yingchen Jiang ,&nbsp;Hao Zhao ,&nbsp;Wanxin Wang ,&nbsp;Yuhua Liao ,&nbsp;Huimin Zhang ,&nbsp;Lan Guo ,&nbsp;Beifang Fan ,&nbsp;Angela T.H. Kwan ,&nbsp;Roger S. McIntyre ,&nbsp;Ciyong Lu ,&nbsp;Xue Han","doi":"10.1016/j.jad.2025.04.036","DOIUrl":"10.1016/j.jad.2025.04.036","url":null,"abstract":"<div><h3>Background</h3><div>To explore the longitudinal associations between stigma and suicidal ideation among patients with major depressive disorder (MDD).</div></div><div><h3>Methods</h3><div>Data were from patients with MDD in the Depression Cohort in China. At baseline and weeks 4, 8, 12, 24, 48, and 72, the presence (yes and no) and severity (scores) of suicidal ideation were evaluated using the Beck Scale for Suicide Ideation, and stigma was assessed using the Depression Stigma Scale. Generalized linear mixed models were used to explore the association between stigma and suicidal ideation.</div></div><div><h3>Results</h3><div>Among 1123 patients with a mean age of 27.9 (SD, 7.3) years, 71.1 % were female. Restricted cubic splines showed positive linear dose-response associations of personal stigma and perceived stigma with the likelihood and severity of suicidal ideation. The adjusted ORs (95 % CIs) for each 10 score increment in personal stigma and perceived stigma were 1.49 (1.18, 1.89) and 1.46 (1.20, 1.77) for the likelihood of suicidal ideation, respectively. The adjusted <em>β</em> coefficients (95 % CIs) for each 10 score increment in personal stigma and perceived stigma were 0.222 (0.121, 0.322) and 0.202 (0.123, 0.281) for suicidal ideation scores, respectively.</div></div><div><h3>Limitations</h3><div>Information on sigma, suicidal ideation, and potential covariates was self-reported, so reporting bias was inevitable.</div></div><div><h3>Conclusions</h3><div>In this longitudinal study in patients with MDD, more severe personal stigma and perceived stigma were associated with a higher likelihood of suicidal ideation and more severe suicidal ideation. These findings suggest that reducing personal stigma and perceived stigma may help prevent suicidal behavior among patients with MDD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights and recommendations for research on predicting non suicidal self-injury among depressive Chinese adolescents","authors":"Jialao Ma ,&nbsp;Pincheng Luo ,&nbsp;Sijia Liu","doi":"10.1016/j.jad.2025.04.037","DOIUrl":"10.1016/j.jad.2025.04.037","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 541-542"},"PeriodicalIF":4.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}