Journal of affective disorders最新文献

{"title":"Association between RAR and the prevalence and prognosis of depression: A population-based study","authors":"Xiao-Feng Zhu ,&nbsp;Yu-Qi Hu ,&nbsp;Zhi-Wei Long ,&nbsp;Ming-Zhu Cao","doi":"10.1016/j.jad.2025.03.100","DOIUrl":"10.1016/j.jad.2025.03.100","url":null,"abstract":"<div><h3>Background</h3><div>Depression has become a significant public health issue. The red blood cell distribution width to albumin ratio (RAR) is regarded as a reliable marker of inflammation and nutritional status, yet the association between them remains unknown. Therefore, this study aims to evaluate the association between RAR and depression.</div></div><div><h3>Methods</h3><div>28,737 participants were included in the National Health and Nutrition Examination Survey 2005–2018. The weighted multivariate logistic regression and Cox regression explored the relationship between RAR and the prevalence and mortality of depression. Restricted cubic spline (RCS) detected nonlinear relationships and threshold effects. The stratified analysis explored potential interaction variables.</div></div><div><h3>Results</h3><div>In the cross-sectional study, 2519 participants (7.67 %) had depression. Weighted multivariate logistic regression showed RAR was independently associated depression (OR = 1.26, 95 % CI = 1.12, 1.42, <em>P</em> &lt; 0.001). In the cohort study, there were 301 cases of all-cause mortality (9.94 %) in depression population, including 77 cases of cardiovascular mortality (2.66 %). Weighted multivariate Cox regression analysis presented that RAR was related to higher all-cause mortality (HR = 1.98, 95 % CI = 1.62, 2.42, <em>P</em> &lt; 0.001) and cardiovascular mortality (HR = 1.73, 95 % CI = 1.19, 2.51, <em>P</em> = 0.004) in the depression population. Subgroup analysis showed that RAR was consistently related to the prevalence and mortality of depression across all subgroups (all <em>P</em> &lt; 0.05). RCS revealed that the relationship between RAR and depression was nonlinear (P for nonlinear = 0.011), while the association between RAR and all-cause mortality was linear (P for nonlinear = 0.245).</div></div><div><h3>Conclusions</h3><div>RAR is significantly associated with the prevalence and prognosis of depression. Nevertheless, more investigation is required to elucidate the underlying processes.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 1-9"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends in prevalence for depressive disorders among women of childbearing age: Age-period-cohort analysis 2021","authors":"Xiang Yan ,&nbsp;Dequan Wu ,&nbsp;Ruojie Li ,&nbsp;Yile Wu ,&nbsp;Xiaoqian Hu ,&nbsp;Xueping Wang ,&nbsp;Kai Huang ,&nbsp;Tao Zhu ,&nbsp;Qiyu Zhu ,&nbsp;Liang Fang ,&nbsp;Guoping Ji","doi":"10.1016/j.jad.2025.03.108","DOIUrl":"10.1016/j.jad.2025.03.108","url":null,"abstract":"<div><h3>Background</h3><div>Depressive disorders (DD) are significant mood disorders with a notable female preference, especially affecting the well-being of women of childbearing age (WCBA). This population with DD was notably associated with severe complications during the perinatal period, leading to unfavourable maternal mortality and morbidity.</div></div><div><h3>Methods</h3><div>This study extracted data from the Global Burden of Disease Study (GBD) 2021. We analysed the number of cases, calculated the age-standardized prevalence rate, and performed the age-period-cohort (APC) model to estimate prevalence trends and age, period, and cohort effects from 1992 to 2021.</div></div><div><h3>Results</h3><div>From 1992 to 2021, the global number of WCBA with DD surged by 59.46 %, reaching 121 million cases up to 2021. India, China, and the USA had over 40 million prevalence cases, accounting for 36.17 % of global prevalence. The global net drift of DD prevalence among WCBA was −0.13 % per year (95 % CI: −0.17 % to −0.09 %). Age effects demonstrated similar patterns that the prevalence risk rose with age. All SDI regions showed unfavourable prevalence risks surging in the period of 2017–2021. The cohort risk of prevalence increased globally in younger generations after the 1987–1996 cohort.</div></div><div><h3>Conclusion</h3><div>Although the overall temporal trend (net drift) presented a downward trend in DD prevalence among WCBA over the past three decades, the prevalence cases had continued to rise with unfavourable period and cohort effects. Since COVID-19 triggered a massive increase in the prevalence of depressive disorders worldwide, there is an urgent need for stakeholders and policy makers to strengthen mental health-care systems.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 124-134"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural dynamics of social anxiety during and after anxiety-provoking and relaxation-inducing: A task and resting-state fMRI study","authors":"Yujin Ko ,&nbsp;Hesun Erin Kim ,&nbsp;Byung-Hoon Kim ,&nbsp;Kyunghee Ham ,&nbsp;Seungmin Lee ,&nbsp;Bohyun Park ,&nbsp;Jae-Jin Kim","doi":"10.1016/j.jad.2025.03.104","DOIUrl":"10.1016/j.jad.2025.03.104","url":null,"abstract":"<div><h3>Background</h3><div>Social anxiety disorder (SAD) is marked by intense fear of social situations and negative evaluation. This study investigated neural effects of SAD-specific imagery scripts and their relationships with Brief Fear of Negative Evaluation (BFNE).</div></div><div><h3>Methods</h3><div>Thirty-six SAD and 32 healthy controls underwent four five-minute fMRI runs: anxiety-provoking imagery, rest, relaxing imagery, and rest. The order of imageries was counterbalanced. Functional connectivity analysis and connectome-based predictive modeling with respect to BFNE were performed using six seed regions, including the bilateral amygdala, left hypothalamus, bilateral dorsomedial prefrontal cortex (DMPFC), left ventromedial PFC (VMPFC), and left posterior cingulate cortex (PCC).</div></div><div><h3>Results</h3><div>Group × task interaction effects were found in connectivity of left amygdala-right cerebellum, left PCC-bilateral superior frontal gyrus, and left PCC-right posterior middle temporal gyrus, and group × engagement effects were discovered in left hypothalamus-bilateral DMPFC and left VMPFC-right DMPFC couplings. Group × task × engagement interactions highlighted aberrant functional connections of right amygdala-left VMPFC, DMPFC-left DLPFC, and left VMPFC-bilateral supplementary motor area in SAD. Patterns of connectivity predicted the BFNE scores in various segments of imagery conditions.</div></div><div><h3>Limitations</h3><div>Patient's medication, physiological measures were not considered. Noisy nature of fMRI could have interfered participants from focusing.</div></div><div><h3>Conclusions</h3><div>Our results revealed disrupted functional connections associated with emotion dysregulation and overly self-referent thinking in SAD. Markedly, patients showed maladaptive responses related to relaxation-inducing blocks, challenging the expected relaxation response. Overall findings emphasized inappropriate engagements of various processes in relaxing circumstances that do not overtly involve social anxiety to be associated with symptomatology.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 655-665"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerometer-derived “weekend warrior” physical activity, genetic susceptibility, and risk of depression and anxiety: The UK Biobank study","authors":"Yahang Liu ,&nbsp;Chen Huang ,&nbsp;Kecheng Wei ,&nbsp;Ruilang Lin ,&nbsp;Ye Yao ,&nbsp;Guoyou Qin ,&nbsp;Yongfu Yu","doi":"10.1016/j.jad.2025.03.110","DOIUrl":"10.1016/j.jad.2025.03.110","url":null,"abstract":"<div><h3>Importance</h3><div>Guidelines recommend 150 min per week (min/wk) or more of moderate to vigorous physical activity (MVPA) for mental health benefits. However, the relative effects of concentrated against more evenly distributed activity patterns remain unclear.</div></div><div><h3>Objective</h3><div>We aimed to examine associations of the accelerometer-derived “weekend warrior (WW)” pattern (MVPA concentrated within 1 to 2 days) vs MVPA spread more evenly with risk of depression and anxiety.</div></div><div><h3>Design, setting, and participants</h3><div>This prospective cohort study included 84,570 participants with accelerometer data identified from the UK Biobank.</div></div><div><h3>Exposures</h3><div>Three MVPA patterns were compared: active WW (MVPA ≥150 min/wk and ≥50 % of total MVPA within 1 to 2 days), active regular (MVPA ≥150 min/wk but not active WW), and inactive (MVPA &lt;150 min/wk).</div></div><div><h3>Main outcomes and measures</h3><div>Cox regression was used to assess the association of MVPA patterns with depression and anxiety, and whether the association differed by different levels of sedentary time (≤6, 7–12, ≥13 h/day) and light physical activity (≤60, 61–150, ≥151 min/day). We also evaluated the combined impact of MVPA patterns and genetic susceptibility on depression and anxiety.</div></div><div><h3>Results</h3><div>During the follow-up of up to 9.40 years, 2098 and 2699 cases of depression and anxiety were identified, respectively. Compared with inactive group, active regular and active WW groups exhibited similarly reduced risks of depression (active regular: HR, 0.74 [95 % CI, 0.66–0.84]; active WW: 0.72 [0.65–0.80]) and anxiety (active regular: 0.77 [0.69–0.86]; active WW: 0.72 [0.66–0.79]). The impact of active regular and active WW groups on depression and anxiety was more pronounced among individuals with excessive sedentary time (≥13 h/day) and insufficient light physical activity (≤60 min/day). Individuals with low genetic risk and active regular (depression: 0.64 [0.48–0.87]; anxiety: 0.62 [0.49–0.79]), as well as low genetic risk and active WW groups (depression: 0.60 [0.47–0.77]; anxiety: 0.59 [0.48–0.72]) exhibited the lowest risks of depression and anxiety compared to those with high genetic risk and inactive group.</div></div><div><h3>Conclusions and relevance</h3><div>Adherence to active physical activity, regardless of physical activity concentrated within 1 to 2 days or more evenly distributed, may help reduce depression and anxiety risks across a population with different genetic risk profiles.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 55-62"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common genetic basis and causality between central nervous system disease and cancer","authors":"Shiheng Tan ,&nbsp;Ning Zhao ,&nbsp;Qingzhen Fu ,&nbsp;Lin Zhu ,&nbsp;Ding Zhang ,&nbsp;Lijing Gao ,&nbsp;Zesong Cheng ,&nbsp;Zinan Li ,&nbsp;Depei Zhang ,&nbsp;Weiwei Bao ,&nbsp;Yanlong Liu ,&nbsp;Fan Wang ,&nbsp;Binbin Cui ,&nbsp;Yashuang Zhao","doi":"10.1016/j.jad.2025.03.122","DOIUrl":"10.1016/j.jad.2025.03.122","url":null,"abstract":"<div><div>The epidemiological associations between central nervous system diseases and cancers have been widely studied, but the shared genetic basis and etiology between these joint phenotypes remain unclear. To explore this issue, we utilized genome-wide association study summary data to investigate the shared genetic architecture and causality between 10 central nervous system diseases and 14 cancers.</div><div>We employed multiple statistical genetic approaches, including global and local genetic correlation, Mendelian randomization, shared loci and genes, and shared tissues and cell-types to systematically and robustly explore the common genetic basis and causal relationships between central nervous system diseases and cancers.</div><div>Our results revealed genetic correlations between schizophrenia and both lung cancer and breast cancer, including estrogen receptor-positive breast cancer, as well as between neuroticism and both lung cancer and ovarian cancer, including serous ovarian cancer. We found causal relationships between schizophrenia and lung cancer (OR = 1.14, <em>P</em> = 0.009) and breast cancer (OR = 1.05, <em>P</em> = 3.00 × 10⁻⁵). When the whole genome was partitioned, significant local correlations of schizophrenia with breast cancer and lung cancer were further discovered within 14 specific genomic regions. Using cross-trait meta-analysis, we identified 24 pleiotropic loci associated with the two joint phenotypes. Using summary-data-based Mendelian randomization, we further identified eight functional genes shared between schizophrenia and both breast cancer and lung cancer, neuroticism and ovarian cancer. Additionally, we observed consistent patterns of single-nucleotide polymorphism heritability enrichment for schizophrenia and lung cancer in T lymphocytes.</div><div>Our study provides insights into the genetic underpinnings and causal relationships of comorbidities between central nervous system diseases and cancers.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 347-356"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights on underlying shared genetic architectures and causality of underweight and depression in East Asian populations","authors":"Ming Chen ,&nbsp;Zhen Xiao ,&nbsp;Yueya Wang ,&nbsp;Wanqi Ou ,&nbsp;Cailan Hou ,&nbsp;Hao-Zhang Huang","doi":"10.1016/j.jad.2025.03.126","DOIUrl":"10.1016/j.jad.2025.03.126","url":null,"abstract":"<div><h3>Background</h3><div>Extensive evidence links a lower body mass index (BMI) to higher odds of depression in individuals of East Asian ancestry, differing from patterns observed in European populations. However, the shared genetic etiology underlying underweight and depression remains unclear in East Asian populations.</div></div><div><h3>Method</h3><div>Utilizing large-scale genome-wide association study (GWAS) data, we investigated the shared genetics between BMI (<em>N</em> = 323,298) and depression traits (<em>N</em> = 286,052) through linkage disequilibrium score regression, cross-trait meta-analysis and colocalization analysis. Additionally, we evaluated causal associations using bidirectional Mendelian randomization (MR) analysis.</div></div><div><h3>Results</h3><div>We found a significantly negative genetic correlation between BMI and depression (rg = −0.19, <em>P</em> = 0.002). The cross-trait analysis identified 26 shared risk SNPs, including <em>FTO</em> and more. Moreover, the risk gene <em>AGBL4</em> showed evidence of colocalization. Using the MR method, lower BMI was associated with higher odds of depression in individuals of East Asian ancestry (OR: 1.14, 95 % CI: 1.02 to 1.28, <em>P</em> = 0.021) but no reverse causal effect was observed.</div></div><div><h3>Conclusions</h3><div>Our study indicates a genetic correlation, shared risk genes, and causality between underweight and depression in East Asian populations. These findings provide insights into the potential mechanisms behind their comorbidity and inform the future development of therapeutics for East Asian populations.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 226-229"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression vulnerability and gray matter integrity of interoceptive networks in remitted depressed outpatients","authors":"Liliana C. Wu ,&nbsp;Zindel V. Segal ,&nbsp;Norman A.S. Farb","doi":"10.1016/j.jad.2025.03.106","DOIUrl":"10.1016/j.jad.2025.03.106","url":null,"abstract":"<div><h3>Background</h3><div>Interoception, the representation of internal body states, plays an important role in mental health. While functional neuroimaging links Major Depressive Disorder (MDD) relapse vulnerability to stress-induced inhibition of sensorimotor regions, its association with structural changes in interoceptive networks remains unclear.</div></div><div><h3>Methods</h3><div>A secondary analysis explored relationships between gray matter volume and relapse vulnerability in remitted MDD patients (N = 85), with two data acquisitions surrounding eight-weeks of prophylactic psychotherapy followed by a two-year follow-up. Participants were randomly assigned to either Cognitive Behavioral Therapy or Mindfulness-Based Cognitive Therapy (MBCT). Mixed-effects models were applied to study the relationships between cortical thickness, time, and intervention type with clinical variables such as relapse status, residual symptoms, and decentering, adjusting for relevant covariates. Analyses were conducted at whole brain levels as well as in pre-defined regions of interest, focusing on sensory regions implicated by prior research.</div></div><div><h3>Results</h3><div>Relapse was consistently linked to greater cortical thickness in the left superior circular sulcus of the insula and the left anterior occipital sulcus. Residual symptoms correlated with increased cortical thickness in the left insula and right precentral regions, while decentering was linked to reduced thickness in the middle temporal and inferior parietal regions. MBCT participants showed greater cortical thickness increases in the right superior temporal gyrus over time.</div></div><div><h3>Conclusions</h3><div>MDD vulnerability was unexpectedly linked to greater cortical thickness in sensory and prefrontal brain regions, suggesting that depression vulnerability may reflect maladaptive skill acquisition. MBCT may promote gray matter growth in the right superior temporal region.</div></div><div><h3>Trial registration</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> <span><span>NCT01178424</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 113-123"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical correlates, lipid metabolic parameters and thyroid hormones are associated with abnormal glucose metabolism in first-episode and drug-naïve major depressive disorder patients with suicide attempts: A large cross-sectional study","authors":"Shiwang Chen ,&nbsp;Jing Wang ,&nbsp;XiaoE Lang ,&nbsp;Xiang-Yang Zhang","doi":"10.1016/j.jad.2025.03.102","DOIUrl":"10.1016/j.jad.2025.03.102","url":null,"abstract":"<div><h3>Background</h3><div>The factors associated with glucose disturbances in major depressive disorder (MDD) patients with comorbid suicide attempts remains unclear. To the best of our knowledge, this is the first study with a large sample size to examine risk factors for glucose disturbances, including clinically relevant factors, lipid metabolic parameters, and thyroid hormone levels in first-episode drug-naïve (FEDN) MDD patients with comorbid suicide attempts.</div></div><div><h3>Methods</h3><div>A total of 1718 FEDN MDD patients were enrolled. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) were used to assess the clinical symptoms of the patients. Fasting blood samples were collected and biochemical parameters were measured, including fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), thyroid stimulating hormone (TSH), free thyroxine (FT4, FT3), anti-thyroid autoantibodies (TgAb), and thyroid peroxidase antibody (TPOAb). Statistical analyses were performed using multivariate logistic regression analyses and receptor operating characteristic curves.</div></div><div><h3>Results</h3><div>The prevalence of glucose disturbances was 24 % in MDD patients with comorbid suicide attempts, which was 1.88 times higher than that in MDD patients without suicide attempts (11 %). Among MDD patients with comorbid suicide attempters, compared with patients without glucose disturbances, patients with glucose disturbances had higher mean scores on the HAMA, HAMD and PANSS positive subscale scores, and higher mean levels of TC, TG, TSH, HDL-C, LDL-C, and TPOAb. The combination of HAMA score, HAMD score, PANSS positive subscale score and TSH distinguished between patients with and without glucose disturbances.</div></div><div><h3>Conclusions</h3><div>Our findings suggest a high prevalence of glucose disturbances in FEDN MDD patients with comorbid suicide attempts. Several clinical correlates, lipid metabolism parameters, and thyroid hormone function are associated with glucose disturbances in MDD patients with comorbid suicide attempts.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 10-16"},"PeriodicalIF":4.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalences and differences of depressive symptomology among first-episode of depression and recurrent depression: An analysis of data from NSSD.","authors":"Jia Huang, Yiyun Cai, Min Zhang, Xianrong Xu, Yousong Su, Na Zhu, Feng Jin, Yiru Fang, Daihui Peng","doi":"10.1016/j.jad.2025.03.103","DOIUrl":"https://doi.org/10.1016/j.jad.2025.03.103","url":null,"abstract":"<p><strong>Background: </strong>The study was designed to fully map and display the hierarchy of depressive symptomology among first-episode and recurrent major depressive disorder (MDD) patients.</p><p><strong>Methods: </strong>This cross-sectional study included 3249 MDD patients from the National Survey on Symptomatology of Depression (NSSD). The prevalences of 64 sets of depressive symptoms in first-episode and recurrent MMD were fully described and compared. Logistic regression and random forest models were used to assess the relative importance of the symptoms in distinguishing first-episode MDD from recurrent MDD.</p><p><strong>Results: </strong>The prevalences of the total 64 sets of the symptoms ranged from 5.7 % to 80.0 %, and depressed mood (80.0 %), pleasure loss (76.0 %), interest loss (72.0 %), low energy (72.0 %), later insomnia (65.0 %) were the top 5 symptoms. 24 symptoms that had a significantly higher prevalence in recurrent MDD patients than those of first-episode MDD patients were identified, especially memory loss (59.0 % vs. 49 %, p < 0.001), suicide history (17.9 % vs. 8.9 %), sense of decreased ability (69.7 % vs. 60.8 %, p < 0.001). The results from logistic regression and random forest analyses consistently indicated that the differences in the prevalences of suicidal behavior, memory loss, and late insomnia may be the most important distinguishing characteristics between first-episode and recurrent MDD.</p><p><strong>Conclusion: </strong>The findings may help develop screening tools for MDD in clinics and provide clues for further mechanistic studies for the recurrence of MDD.</p><p><strong>Limitations: </strong>Because of the study's cross-sectional design, causal conclusions could not be drawn between the differences in the prevalences of symptoms and recurrence of MDD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From anxiety to depression: A longitudinal investigation into the role of anhedonia","authors":"Amanda C. Collins ,&nbsp;Michael R. Gallagher ,&nbsp;Camryn Calafiore ,&nbsp;D. Gage Jordan ,&nbsp;E. Samuel Winer","doi":"10.1016/j.jad.2025.03.074","DOIUrl":"10.1016/j.jad.2025.03.074","url":null,"abstract":"<div><div>Anxiety and depression are highly comorbid with each other, warranting a need to better understand transdiagnostic mechanisms. Anhedonia has been hypothesized as a transdiagnostic mechanism but has often been investigated as a unidimensional factor. Thus, the current study examined how anticipatory and consummatory anhedonia, including how they interact with anxiety, predict next-week depression. Participants (<em>N</em> = 101) completed weekly assessments of anxiety, depression, and anhedonia. Using an iterative approach, we constructed four models to investigate independent and interactive effects of prior-week anxiety and anhedonia on next-week depression, as well as the effects of depression and anhedonia on anxiety. Our results indicate that anticipatory anhedonia is associated with next-week depression, and the association between anxiety and depression is greater when anticipatory anhedonia is high. The current findings provide insight into the transdiagnostic nature of anticipatory anhedonia between anxiety and depression. Future work should investigate how these associations may unfold over shorter time periods.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 17-25"},"PeriodicalIF":4.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}