Journal of affective disorders最新文献

{"title":"Neuromonitoring-guided anesthesia depth versus four-minute anesthesia-to-stimulation time interval in electroconvulsive therapy for depressive disorders – A single-blinded, prospective, randomized and controlled study","authors":"Vitaliy Pustilnik ,&nbsp;Michel Heil ,&nbsp;Wolfgang Lederer ,&nbsp;Judith Martini ,&nbsp;Laurin Mauracher ,&nbsp;Timo Schurr ,&nbsp;Elisabeth Gasteiger ,&nbsp;Monika Edlinger ,&nbsp;Lukas Gasteiger","doi":"10.1016/j.jad.2025.01.113","DOIUrl":"10.1016/j.jad.2025.01.113","url":null,"abstract":"<div><h3>Background</h3><div>Anesthesia depth influences seizure quality in patients undergoing electroconvulsive therapy (ECT). EEG-based neuromonitoring has been shown to detect adequate anesthesia depth for ECT. Anesthesia depth-guided ECT management may therefore be a reliable alternative to the predetermined anesthesia-to-stimulation time interval.</div></div><div><h3>Methods</h3><div>Patients with depressive disorders and a Montgomery-Asberg Depression Rating Score ≥ 18 were randomly assigned. The anesthesia depth-guided group received stimulation between Narcotrend™ index ratings of 41 and 64 and was compared to the control group with a predetermined anesthesia-to-stimulation time interval of four minutes. The primary endpoint was seizure quality.</div></div><div><h3>Results</h3><div>A total of 225 interventions were conducted in 30 patients. Significant differences were observed between the two groups regarding stimulation intervals (225.0 ± 34.2 s vs. 240.0 ± 0 s; p &lt; 0.001) and the index before electric stimulation (45.0 ± 15.7 vs. 35.0 ± 13.0; p &lt; 0.001). No significant differences in overall seizure quality were found between the groups. The midictal amplitude was higher in the anesthesia depth-guided group (209.2 ± 92.6 vs. 152.6 ± 80.0; p = 0.009). Because of inadequate anesthesia depth, 54 interventions were discontinued for safety reasons.</div></div><div><h3>Limitations</h3><div>The number of per protocol completed interventions is small due to high exclusion rate from protocol violations.</div></div><div><h3>Conclusions</h3><div>Anesthesia depth-guided ECT management did not significantly improve overall seizure quality compared to a four-minute anesthesia-to-stimulation time interval.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 231-238"},"PeriodicalIF":4.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of breakfast habits and breakfast quality with depression symptoms: A cross-sectional study based on NHANES 2007–2018","authors":"Mengzi Sun ,&nbsp;Zibo Wu","doi":"10.1016/j.jad.2025.01.115","DOIUrl":"10.1016/j.jad.2025.01.115","url":null,"abstract":"<div><h3>Background</h3><div>Breakfast, often considered the most important meal of the day, affects both physical and mental health. While most studies focused on the effects of skipping breakfast on depression, few explored the roles of breakfast quality and breakfast time. The study aimed to investigate the association of breakfast habits and breakfast quality with depression symptoms.</div></div><div><h3>Methods</h3><div>This study included 23,839 participants aged 20 and older from the 2007–2018 National Health and Nutrition Examination Survey (NHANES). Breakfast habits were assessed using two 24-h dietary recalls, capturing both whether and when breakfast was consumed. Breakfast quality was assessed by calculating the Breakfast Quality Score (BQS). Depression symptoms was diagnosed using the Patient Health Questionnaire (PHQ-9). Binary logistic regression was used to explore the associations.</div></div><div><h3>Results</h3><div>Compared to participants who did not report breakfast, the ORs of participants who reported breakfast on both one recall and both recalls were 0.737(0.591,0.919) and 0.766(0.624,0.939) for depression symptoms. Compared to participants in the BQS T₁ subgroup, the ORs of participants in the T₂ subgroup and T₃ subgroup were 0.895(0.723,1.108) and 0.716(0.564,0.908) for depression symptoms (<em>P</em> for trend = 0.013). Compared to participants who had breakfast before 8:00 AM, the ORs for depression symptoms were 1.104 (95 % CI: 0.888, 1.371) for those who had breakfast between 8:00–9:00 AM and 1.278 (95 % CI: 1.030, 1.587) for those who had breakfast after 9:00 AM.</div></div><div><h3>Conclusions</h3><div>Skipping breakfast, low breakfast quality, and late breakfast are independently associated with depression symptoms.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 342-348"},"PeriodicalIF":4.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and social contact with dementia risk: A prospective cohort study","authors":"Yufei Liu ,&nbsp;Jie Chang ,&nbsp;Yiwei Zhao ,&nbsp;Peiyang Gao ,&nbsp;Yi Tang","doi":"10.1016/j.jad.2025.01.112","DOIUrl":"10.1016/j.jad.2025.01.112","url":null,"abstract":"<div><h3>Background</h3><div>Frailty and social contact are significant factors influencing dementia risk. While previous studies have separately examined these factors, their combined impact on dementia remains underexplored.</div></div><div><h3>Methods</h3><div>This study included 338,567 UK biobank participants from 2006 to 2010, with follow-up until December 2022. Additionally, 30,408 participants with brain magnetic resonance imaging data were analyzed for hippocampal volume. Cox proportional hazards regression and linear regression models were used to assess associations.</div></div><div><h3>Results</h3><div>The study followed 338,567 participants (mean [SD] age, 60.4 [5.2] years; 54.1 % men) for a median of 13.7 years, documenting 7362 cases of all-cause dementia. Both frailty and lower social contact independently increased the risk of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD). Compared to individuals with non-frailty and high social contact, those with lower social contact and higher frailty had a significantly increased risk of all-cause dementia, with the highest risk observed in individuals with frailty and low social contact (HR = 2.65, 95 % CI: 2.27–3.11). Similar patterns were found for AD and VaD. Furthermore, hippocampal volume was significantly reduced in individuals with frailty and low social contact (β = −0.24, 95 % CI: −0.43 to −0.06) compared to those with non-frailty and high social contact.</div></div><div><h3>Limitations</h3><div>The study predominantly included European descent individuals, with most frailty and social contact data based on baseline self-reports.</div></div><div><h3>Conclusions</h3><div>The combination of frailty and low social contact is associated with the highest risk of dementia. These findings suggest that both physiological and social factors should be simultaneously considered in dementia prevention strategies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 129-136"},"PeriodicalIF":4.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute angiotensin receptor blockade and mnemonic discrimination in healthy participants","authors":"Divya Prasad ,&nbsp;Lorika Shkreli ,&nbsp;Riccardo De Giorgi ,&nbsp;Sara Costi ,&nbsp;Andrea Reinecke","doi":"10.1016/j.jad.2025.01.119","DOIUrl":"10.1016/j.jad.2025.01.119","url":null,"abstract":"<div><h3>Background</h3><div>The renin angiotensin system (RAS) is implicated in various cognitive processes relevant to anxiety. However, the role of the RAS in pattern separation, a hippocampal memory mechanism that enables discrete encoding of similar stimuli, is unclear. Given the proposed role of this mechanism in overgeneralization and the maintenance of anxiety, we explored the influence of the RAS on mnemonic discrimination, i.e., the behavioral ability arising from pattern separation.</div></div><div><h3>Design</h3><div>In a double-blind experimental medicine trial, we examined the effect of losartan, an angiotensin receptor blocker, on mnemonic discrimination in <em>N</em> = 60 healthy volunteers aged 18–50. Participants were randomly allocated to a 50 mg losartan or placebo condition, and then completed the Mnemonic Similarity Task (MST), an established measure of mnemonic discrimination. Main outcome measures were the lure discrimination index (LDI), calculated as the rate of ‘similar’ responses to lures minus ‘similar’ responses to foils, and recognition (REC) memory, calculated as the difference between the rate of ‘old’ responses to targets minus ‘old’ responses to foils.</div></div><div><h3>Results</h3><div>Data were available for <em>N</em> = 56 participants (<em>N</em> = 40 females, <em>N</em> = 16 males). Participants in the losartan group (<em>N</em> = 29) achieved significantly higher LDI scores (<em>t(54)</em> <em>=</em> <em>2.30, p</em> <em>=</em> <em>0.025</em>) compared to the placebo group (<em>N</em> = 27), indicating better mnemonic discrimination. No significant group differences were found in REC scores (<em>U</em> = 324, z = −1.10, <em>d =</em> 0.08; <em>p</em> = 0.271).</div></div><div><h3>Conclusions</h3><div>We demonstrate for the first time that losartan improves mnemonic discrimination in healthy individuals, suggesting that the RAS may influence pattern separation and anxiety.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 293-296"},"PeriodicalIF":4.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An umbrella review and meta-analysis of 87 meta-analyses examining healthcare workers' mental health during the COVID-19 pandemic","authors":"Vincent Gosselin Boucher ,&nbsp;Maria Dahl ,&nbsp;Jayden Lee ,&nbsp;Guy Faulkner ,&nbsp;Mark R. Beauchamp ,&nbsp;Eli Puterman","doi":"10.1016/j.jad.2025.01.109","DOIUrl":"10.1016/j.jad.2025.01.109","url":null,"abstract":"<div><div>During the COVID-19 pandemic, healthcare workers (HCWs) experienced several changes in their work (e.g., longer hours, new policies) that affected their mental health. In this study, an umbrella review and meta-analysis of meta-analyses was conducted to examine the prevalence of various mental health problems experienced by HCWs during the COVID-19 pandemic. We conducted a systematic review searching PubMed, EMBASE, PsycINFO, Cochrane Library, and Scopus databases (PROSPERO: CRD42022304823). We performed a meta-analysis to summarize prevalence of different mental health problems and examined whether these differed as a function of job category, sex/gender, sociodemographic index (SDI), and across time. Eighty-seven meta-analyses were included in the umbrella review and meta-analysis, including 1846 non-overlapping articles and 9,400,962 participants. The overall prevalence ratio for the different mental health outcomes ranged from 0.20 for PTSD (95 % CI: 0.16–0.25) to 0.44 for burnout (95 % CI: 0.32–0.56), with ratios for depressive symptoms, anxiety symptoms, psychological distress, perceived stress, sleep problems, and insomnia symptoms falling between these ranges. Follow-up analyses revealed little variation in outcomes across job category, and sex. Prevalence of mental health problems in HCWs was high during the pandemic. Administrators and policymakers worldwide need to address these growing problems through institutional policies and wellness programming.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 423-436"},"PeriodicalIF":4.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health risk behaviors, depressive symptoms and suicidal ideation among college students: A latent class analysis in middle China","authors":"Jingjing Xiang ,&nbsp;Fei Peng ,&nbsp;Jiayi Jiao ,&nbsp;Ting Tan ,&nbsp;Ling Liu ,&nbsp;Maowei Chen ,&nbsp;Jingtao Wang ,&nbsp;Dan Luo ,&nbsp;Shuang Liu","doi":"10.1016/j.jad.2025.01.107","DOIUrl":"10.1016/j.jad.2025.01.107","url":null,"abstract":"<div><h3>Purpose</h3><div>Previous studies have demonstrated the relationship between health risk behaviors and mental health, but little is discussed among college students. The current study aims to examine clusters of health risk behaviors and their correlation with depressive symptoms and suicidal ideation among Chinese college students.</div></div><div><h3>Methods</h3><div>Data was obtained from the 2022 Surveillance for Common Diseases and Health Risk Factors among Students project conducted by the Hubei Province of the Centers for Disease Control and Prevention. Latent class analysis (LCA) was conducted based on health risk behaviors, including diet (breakfast skipping, consumption of sweetened beverages, fast food, milk, soymilk and yogurt), physical activities (physical exercise and sedentary), adverse experiences (verbal violence and emotional neglect), substance use (smoking and drinking), sleep, and unprotected sex behaviors. Mental health was assessed by the depressive symptoms and suicidal ideation. Multivariate logistic regression evaluated the correlation between mental health and health risk behaviors.</div></div><div><h3>Results</h3><div>Among the 6372 Chinese college students, most had sedentary behavior, physical inactivity and unhealthy diet, and &gt; 60 % had more than two health risk behaviors. We further identified four classes of health risk behaviors using LCA. Class 1 (low-risk group, 25.1 %) was unlikely to engage in health-risk behaviors. Class 2 (moderate-risk group, 66.9 %) showed the lowest or second lowest probabilities of most health risk behaviors. Class 3 (High-risk-substance abuse/unprotected sex, 5.2 %) presented the highest probabilities of smoking, drinking, irregular breakfast, unhealthy diet and unprotected sex. Class 4 (High-risk-adverse experiences, 2.8 %) showed the highest probabilities of verbal violence, emotional neglect and insufficient sleep. The high-risk (adverse experiences) class had the highest odds of both depressive symptoms and suicidal ideation, followed by Class 3 and Class 2. Moreover, single-parent and intergenerational families were positively associated with mental health problems in female college students.</div></div><div><h3>Limitations</h3><div>Due to the cross-sectional study, we cannot identify the changes in different developmental stages.</div></div><div><h3>Conclusion</h3><div>Different intervention strategies should be customized based on clustering patterns of health risk behaviors in the prevention of depression and suicide among college students.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 205-213"},"PeriodicalIF":4.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific symptomatology profile associated with treatment resistant depression: A multicentric study from the Group for the Study of Resistant Depression with a focus on sex","authors":"Maria Luca ,&nbsp;Antonina Luca ,&nbsp;Antonino Messina ,&nbsp;Lucie Bartova ,&nbsp;Siegfried Kasper ,&nbsp;Joseph Zohar ,&nbsp;Daniel Souery ,&nbsp;Stuart Montgomery ,&nbsp;Panagiotis Ferentinos ,&nbsp;Dan Rujescu ,&nbsp;Julien Mendlewicz ,&nbsp;Raffaella Zanardi ,&nbsp;Raffaele Ferri ,&nbsp;Bartolo Lanuzza ,&nbsp;Francesco Benedetti ,&nbsp;Basilio Pecorino ,&nbsp;Bernhard T. Baune ,&nbsp;Giuseppe Fanelli ,&nbsp;Chiara Fabbri ,&nbsp;Alessandro Serretti","doi":"10.1016/j.jad.2025.01.120","DOIUrl":"10.1016/j.jad.2025.01.120","url":null,"abstract":"<div><h3>Background</h3><div>Clinical predictors of treatment-resistant depression could improve treatment strategies. Depressive symptom profiles at baseline are potential outcome predictors, but little evidence is available, and sex-specific profiles have been scarcely investigated.</div></div><div><h3>Methods</h3><div>Baseline symptom scores of 1294 patients with major depressive disorder were assessed by the Montgomery-Åsberg depression rating scale (MADRS) as part of a multicenter study by the “Group for the Studies of Resistant Depression”. Treatment outcomes were assessed according to the MADRS after ≥4 weeks of naturalistic treatment. We tested if individual MADRS item scores at baseline were associated with treatment outcome in the whole sample and in sex-stratified subgroups.</div></div><div><h3>Results</h3><div>A specific baseline symptom profile was associated with non-response in the whole sample. In particular, apparent and reported sadness, reduced sleep, lassitude, inability to feel, and pessimistic thoughts were the only MADRS items that scored higher at baseline in patients with subsequent lack of response. In the sex-stratified analysis, females showed a similar profile overall, however they showed higher baseline levels of inner tension, inability to feel, and pessimistic thoughts compared to males, and these symptoms were associated with lack of response in females but not in males. Neurovegetative symptoms were poorly predictive. Overall baseline severity related to poor response.</div></div><div><h3>Limitations</h3><div>This is a post-hoc analysis. The naturalistic design of the study with a retrospective assessment is potential limitations.</div></div><div><h3>Conclusion</h3><div>A specific baseline symptom profile characterized by higher sadness, reduced sleep and anhedonic features may be indicative of poor treatment outcome. Females showed a distinctive baseline profile associated with poor response.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 249-255"},"PeriodicalIF":4.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychophysiological stress response, emotion dysregulation and sleep parameters as predictors of psychopathology in adolescents and young adults","authors":"Caroline L.M. Herber ,&nbsp;Christoph Breuninger ,&nbsp;Brunna Tuschen-Caffier","doi":"10.1016/j.jad.2025.01.110","DOIUrl":"10.1016/j.jad.2025.01.110","url":null,"abstract":"<div><h3>Background</h3><div>Increased emotional reactivity to stress, emotional dysregulation and sleep disturbances are interdependent trans-diagnostic processes that are present in internalising disorders such as depression and anxiety disorders. This study investigated which objective and subjective parameters of stress reactivity, sleep and emotional processing would predict symptoms of anxiety and depression in adolescents and young adults.</div></div><div><h3>Methods</h3><div>Participants were adolescents and young adults between the ages of 14 to 21 (<em>N</em> = 106, 25[24 %] male, <em>M</em> age = 17.93). Heart rate, heart rate variability, and subjective stress levels were measured before, during and after a stress induction using the Trier Social Stress Test (TSST). Questionnaires on internalising symptoms, emotion dysregulation, and sleep quality were used. For seven consecutive nights, objective sleep parameters were measured with a wearable device.</div></div><div><h3>Results</h3><div>Heart rate and heart rate variability after (but not during) the stress induction and emotion dysregulation predicted depressive and anxiety symptoms. Lower subjective sleep quality (but not the objective sleep parameters) was associated with depressive and anxiety symptoms. Emotion dysregulation mediated the relationship between sleep quality and depressive symptoms.</div></div><div><h3>Limitations</h3><div>A cross-sectional design, no measurement of daily activity or naps, and only self-report measures of depressive and anxiety symptoms as well as emotion dysregulation.</div></div><div><h3>Conclusion</h3><div>The findings of elevated cardiovascular activation after – but not during – the stress induction and emotion dysregulation underlines problems in regulating and recovering from stress as predictors of youth internalising psychopathology. Differences between subjective and objective measures of sleep and stress reactivity suggests a role of cognitive biases in these domains.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 331-341"},"PeriodicalIF":4.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral microbiota among treatment-naïve adolescents with depression: A case-control study","authors":"Yingying Zeng ,&nbsp;Xiaonan Jia ,&nbsp;Houyi Li ,&nbsp;Ni Zhou ,&nbsp;Xuemei Liang ,&nbsp;Kezhi Liu ,&nbsp;Bao-Zhu Yang ,&nbsp;Bo Xiang","doi":"10.1016/j.jad.2025.01.089","DOIUrl":"10.1016/j.jad.2025.01.089","url":null,"abstract":"<div><h3>Background</h3><div>Adolescent depression has profound impacts on physical, cognitive, and emotional development. While gut microbiota changes have been linked to depression, the relationship between oral microbiota and depression remains elusive. Our study aims to investigate the oral microbiota in treatment-naïve adolescents experiencing depression and examine their potential associations with cognitive function.</div></div><div><h3>Methods</h3><div>Our case-control study comprised two groups of adolescents aged 12–17: the depression group, including treatment-naïve individuals diagnosed with DSM-5 major depressive disorder (MDD), and a healthy control group of non-depressed individuals (HC). Participants underwent structured neuropsychiatric assessments, and fasting morning saliva samples were collected for the 16S rRNA sequencing to investigate the oral microbiota.</div></div><div><h3>Results</h3><div>Significant differences were identified in the α- and β<em>-</em>diversities of the oral microbiota between MDD and HC groups. Specific bacterial taxa, including genera <em>Streptococcus</em>, <em>Neisseria</em>, <em>Hemophilus</em>, <em>Fusobacterium</em>, and <em>g_norank_f_norank_o_Absconditabacteriales_SR1</em>, were significantly associated with MDD. The association extends to cognitive functions, where correlations were observed between certain oral bacteria and cognitive scores, including instant and delayed memory, visual breadth, and speech features for the combined MDD and HC individuals (<em>p</em> &lt; 0.05). Random forest analysis identified ten genera of oral microbes with the highest predictive values for MDD. The area under the curve (AUC) is 0.78 in the receiver operating characteristic (ROC) curve analysis.</div></div><div><h3>Conclusion</h3><div>Our results highlight the oral microbiota's role as a biomarker for adolescent depression and its impact on cognitive functions. These insights underscore the need for further research into the links between oral health, mental health, and cognitive functions.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 93-102"},"PeriodicalIF":4.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual patterns of activity predict the response to physical exercise as an intervention in mild to moderate depression","authors":"Stefan Spulber ,&nbsp;Sandra Ceccatelli ,&nbsp;Yvonne Forsell","doi":"10.1016/j.jad.2025.01.097","DOIUrl":"10.1016/j.jad.2025.01.097","url":null,"abstract":"<div><div>Physical exercise (PE) as antidepressive intervention is a promising alternative, as shown by multiple meta-analyses. However, there is no consensus regarding optimal intensity and duration of exercise, and there are no objective criteria available for personalized indication of treatment. The aims of this study were (1) to evaluate whether individual activity patterns before intervention can predict the response to treatment; and (2) to evaluate whether the patient outcome can be improved by using prior information on treatment efficacy at individual level. The study included subjects with mild to moderate depression randomized to three PE regimens as antidepressive intervention. Features extracted from actigraphy recordings were used for training linear regression ensembles to predict the response to treatment. The Bayesian analysis of coefficients yielded distinct signatures in enriched feature subsets for each PE regimen. Next, we used a counterfactual approach by virtually assigning each patient to the PE regimen predicted to yield best outcome. This procedure significantly increased the remission rates as compared to random assignment to treatment. Our data suggest that the analysis of individual patterns of activity can identify a PE regimen to yield the best results, and that assignment to PE regimen using this information would significantly increase remission rate.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 118-128"},"PeriodicalIF":4.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}