Journal of affective disorders最新文献

{"title":"The impact of neighborhood environment on adolescent anxiety and depression: A moderated mediation model involving screen time and family function","authors":"Qian-Wen Xie ,&nbsp;Xu Li Fan ,&nbsp;Yuan Sun ,&nbsp;Yawen Xuan ,&nbsp;Jingjing Lu ,&nbsp;Xudong Zhou","doi":"10.1016/j.jad.2025.119751","DOIUrl":"10.1016/j.jad.2025.119751","url":null,"abstract":"<div><h3>Objective</h3><div>While the relationship between neighborhood environment and adolescent mental health is well-documented, few studies have examined the roles of screen time and family function in this association. This study aims to explore the “environment-behavior-health” pathway by investigating how neighborhood environment, screen time, and family function jointly influence adolescent anxiety and depression.</div></div><div><h3>Method</h3><div>Data were drawn from a large-scale, two-wave survey of 5th–12th grade Chinese adolescents. A moderated mediation model was constructed to examine whether screen time mediates the relationship between neighborhood environment and adolescent anxiety and depression, and whether this indirect effect is moderated by family function.</div></div><div><h3>Results</h3><div>The final sample included 8961 Chinese adolescents. Neighborhood environment was negatively associated with adolescents' screen time (b = −0.513, <em>p</em> &lt; 0.001), anxiety (b = −0.984, p &lt; 0.001) and depression (b = −1.357, p &lt; 0.001). Screen time partially mediated the effects of neighborhood environment on anxiety (b = −0.048, 95 % CI [−0.075, −0.025]) and depression (b = −0.068, 95 % CI [−0.102, −0.039]). Moreover, family function significantly moderated the association of neighborhood environment with anxiety (b = −0.441, <em>p</em> &lt; 0.01) and depression (b = −0.401, <em>p</em> &lt; 0.05), as well as the association of screen time with anxiety (b = −0.055, p &lt; 0.01) and depression (b = −0.051, p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>These findings extend the “environment-behavior-health” framework and highlight the need for multi-level strategies to support adolescent mental health.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119751"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidities and emotions - unpacking the sentiments of pediatric patients with multiple long-term conditions through social media feedback: A large language model-driven study","authors":"Temidayo I. Oluwalade ,&nbsp;Hossein Ahmadi ,&nbsp;Lin Huo ,&nbsp;Richard Sharpe ,&nbsp;Shang-Ming Zhou","doi":"10.1016/j.jad.2025.119752","DOIUrl":"10.1016/j.jad.2025.119752","url":null,"abstract":"<div><h3>Objectives</h3><div>The emotional and psychological challenges faced by children with multiple long-term conditions (MLTCs) remain underexplored. This study aimed to analyze sentiments and emotions expressed by this vulnerable population and their caregivers on social media, assess the effects of comorbidities and the COVID-19 pandemic on emotional well-being.</div></div><div><h3>Methods</h3><div>Narratives from the Care Opinion platform (2008–2023) were analyzed by a model called CoEmoBERT, developed using the large language model, distilroberta-base transformer model. The CoEmoBERT-based sentiment analysis categorized emotions into “Positive”, “Negative”, and “Neutral,” with further refinements into specific emotions such as “Sad,” “Fear”, “Satisfied” etc. through pretraining and transferring process. Comorbidity associations with emotions were analyzed. We further examined the impact of the COVID-19 pandemic on patient sentiments and investigated temporal trends in emotional expressions.</div></div><div><h3>Results</h3><div>Of 389 narratives, 93.8 % reflected negative sentiments, with “Sad” (60.9 %) and “Fear” (15.4 %) being the most prevalent. Negative emotions were linked to severe comorbidities like asthma, cancer, and chronic pain, highlighting the emotional burden of managing MLTCs. Positive sentiments (5.9 %) were associated with effective communication and exceptional healthcare experiences. The analysis revealed strong associations between certain comorbidity combinations and specific emotional responses, with mental health conditions showing the most diverse range of comorbidities and emotional impacts. The COVID-19 pandemic exacerbated negative sentiments, particularly sadness and disgust.</div></div><div><h3>Conclusion</h3><div>This study underscores the significant emotional burden on children with MLTCs, emphasizing the need for integrated care approaches to both physical and emotional well-being. These findings can guide the development of patient-centered care for this population.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119752"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food insecurity is associated with depressive and anxiety symptoms among caregivers of young children in arid and semi-arid regions of Kenya: A cross-sectional study","authors":"Esther Jebor Chongwo ,&nbsp;Anja C. Huizink ,&nbsp;Daisy Chelangat ,&nbsp;Eunice Njoroge ,&nbsp;Barack Aoko ,&nbsp;Martha Kaniala ,&nbsp;Moses Esala ,&nbsp;Phillis Magoma ,&nbsp;Joyce Marangu ,&nbsp;Margaret Kabue ,&nbsp;Daniel Rabok ,&nbsp;Susan Nyamanya ,&nbsp;Anil Khamis ,&nbsp;John Ng'asike ,&nbsp;Abubakar Baasba ,&nbsp;Siad Guyo ,&nbsp;Amina Abubakar","doi":"10.1016/j.jad.2025.119754","DOIUrl":"10.1016/j.jad.2025.119754","url":null,"abstract":"<div><h3>Introduction</h3><div>This study fills a critical gap by assessing the prevalence and association between food insecurity and depressive and anxiety symptoms among caregivers of young children in Kenya's arid and semi-arid lands (ASALs).</div></div><div><h3>Methods</h3><div>A cross-sectional design was used to collect data from caregivers of children aged 0–3 years from Lamu, Isiolo and Turkana Counties (<em>N</em> = 446). Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 scales were used to assess depressive and anxiety symptoms, respectively. We also administered the Household Food Insecurity Access Scale, alongside sociodemographic and health-related questionnaires.</div></div><div><h3>Results</h3><div>The mean caregiver age was 29.37 years (SD = 6.56). Majority of participants (73.09 %) lacked improved sanitation, and 33.86 % had their first pregnancy before age 18. High levels of depressive (22.4 %) and anxiety symptoms (11.2 %) were observed. Food insecurity was significantly associated with both depressive (β = 0.24, 95 % CI [0.18 to 0.30], <em>p</em> &lt; 0.001) and anxiety (β = 0.15, 95 % CI [0.10 to 0.21], p &lt; 0.001) symptoms. Increased maternal age, higher education, and having a child with chronic illness were significant risk factors for depressive and anxiety symptoms.</div></div><div><h3>Conclusion</h3><div>Depressive and anxiety symptoms are highly prevalent among caregivers in Kenya's ASAL and are significantly associated with food insecurity. These findings underscore the need for integrating mental health screening and support into maternal and child health programs and addressing food insecurity through multi-sectoral interventions. Further research is needed to explore the nexus between food insecurity, mental health, and other contextual factors influencing caregivers and child well-being in ASAL regions.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119754"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying potential pathogenic oxidative stress-related genes in depression through multi-omics summary-data-based Mendelian randomization analysis","authors":"Junxiang Cheng ,&nbsp;Zhifen Liu ,&nbsp;Ruifang Zhu ,&nbsp;Qia Liu ,&nbsp;Hong Han ,&nbsp;Na Liu ,&nbsp;Juan Shi ,&nbsp;Shifan Han ,&nbsp;Ning Ma","doi":"10.1016/j.jad.2025.119734","DOIUrl":"10.1016/j.jad.2025.119734","url":null,"abstract":"<div><h3>Purpose</h3><div>The relationship between oxidative stress-related genes (OSGs) and depression remains unclear. This study investigates causal associations between OSGs and depression susceptibility to elucidate their roles in this mental health condition.</div></div><div><h3>Methods</h3><div>This study employed a Summary-data-based Mendelian randomization (SMR) approach to investigate the associations between oxidative stress-related genes (OSGs) and depression risk. Differentially expressed genes (DEGs) associated with depression were identified from merged Gene Expression Omnibus transcriptome data and intersected with OSGs from GeneCards to define depression-related OSGs (DeOSGs). SMR analyses using methylation quantitative trait loci (mQTL), expression quantitative trait loci (eQTL), and protein quantitative trait loci (pQTL) data from large-scale consortia and cohorts evaluated associations between DeOSG methylation, expression, and protein levels with depression risk. Colocalization analysis identified shared causal variants between traits. Functional enrichment and validation using FinnGen cohorts further supported findings.</div></div><div><h3>Results</h3><div>We identified 488 DeOSGs in depression patients. SMR analyses across mQTL, eQTL, and pQTL levels identified 130 methylation sites, 28 genes, and three proteins linked to depression risk. Ten CpG sites and three DeOSGs showed strong colocalization evidence. Integrative analysis identified four genes (<em>BRAF, CUTA, SLC27A3,</em> and <em>SMARCA4</em>) as potential candidates influencing depression risk through methylation and expression changes. External validation in the FinnGen cohort confirmed a negative association for <em>CUTA</em> expression in blood eQTL data.</div></div><div><h3>Conclusions</h3><div>This study identified <em>BRAF, CUTA, SLC27A3,</em> and <em>SMARCA4</em> as influencing depression risk through methylation and expression changes. These findings provide potential targets for future therapeutic exploration and biomarker development.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119734"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mood stabilizers: Insights from users' perceptions","authors":"M.F. Tagni ,&nbsp;S.A. Strejilevich ,&nbsp;S. Camino ,&nbsp;E. Carballo ,&nbsp;M. Guglielmetti ,&nbsp;L. López Escalona ,&nbsp;M. Oppel ,&nbsp;L. Sabattini ,&nbsp;A. Szmulewicz","doi":"10.1016/j.jad.2025.119753","DOIUrl":"10.1016/j.jad.2025.119753","url":null,"abstract":"<div><h3>Background</h3><div>Opinions and subjective perceptions regarding psychopharmacological treatment have proven to be strong predictors of quality of life, adherence, and general outcomes, as well as a rich source of data for research. Although mood stabilizing agents (MSA) represent the cornerstone of the treatment of bipolar disorders (BDs), data on the experiences of patients undergoing treatment with these drugs are scarce. We aimed to explore and compare user-reported data on four first-line MSA and identify predictors of treatment satisfaction.</div></div><div><h3>Methods</h3><div>We conducted a quantitative analysis of a random sample of 200 posts specifically related to first-line mood stabilizers (lithium, lamotrigine, valproate, and quetiapine) from individuals undergoing long-term treatment for BDs. Demographical, clinical, somatic, and emotional/psychological side-effects and treatment-related data were analyzed.</div></div><div><h3>Results</h3><div>This study found that the reported levels of satisfaction with MSAs were notably high. Lamotrigine received higher satisfaction ratings than quetiapine and valproate, after including age, sex, dose, and length of treatment in the models. Lithium was rated higher than valproate and quetiapine, although this difference did not reach statistical significance. Obsessive-compulsive symptoms, emotional hyperreactivity, cognitive symptoms, anxiety, weight gain, and gastrointestinal symptoms emerged as significant predictors of treatment dissatisfaction.</div></div><div><h3>Conclusions</h3><div>The findings of this study underscore the significant role that emotional and psychological side effects play in treatment dissatisfaction during MSA use. Both research and clinical decisions should consider the subjective experiences of patients undergoing MSA treatment.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119753"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neutrophil percentage-to-albumin ratio mediates the association between depression and all-cause mortality in U.S. adults: Evidence from NHANES 2009-2018.","authors":"Kunxiu Wang, Gaofeng Liu, Yuchen Pan, Siyu Li, Xiaoling Zhu, Hui Qu, Xuesong Liang, Song Chen, Wenbin Fu","doi":"10.1016/j.jad.2025.119736","DOIUrl":"10.1016/j.jad.2025.119736","url":null,"abstract":"<p><strong>Background: </strong>Depression significaantly reduces the quality of life for hundreds of millions of people globally. Evidence suggests associations among depression, the neutrophil percentage-to-albumin ratio (NPAR), and all-cause mortality (ACM). However, the interrelationship was not elucidated. This study aimed to unveil whether NPAR mediates the correlation between depression and ACM.</p><p><strong>Methods: </strong>A cross-sectional study was carried out based on data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018. ACM data were collected up to December 31, 2019. Weighted binary logistic regression and generalized linear regression models were leveraged to unravel pairwise associations among depression scores, NPAR, and ACM. Mediation analysis was performed to evaluate the potential mediating effects of NPAR on the relationship between depression and ACM.</p><p><strong>Results: </strong>18,709 participants were encompassed. In the fully adjusted model, depression scores (OR [95 % CI]: 1.035 [1.012, 1.058]) and NPAR (OR [95 % CI]: 1.15 [1.108, 1.194]) were significantly positively linked to ACM. Depression scores were positively correlated with NPAR (β [95 % CI]: 0.014 [0.001, 0.026]). NPAR mediated 5.27 % of the total association between depression and ACM. Subgroup analyses revealed that the mediating effect of NPAR was more prominent in specific populations.</p><p><strong>Conclusion: </strong>Among U.S. adults, depression significantly increases the risk of ACM, and this relationship is mediated by NPAR. The mediating effect of NPAR varied by sex, age, race, and health status. These findings fill gaps in the existing literature.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119736"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural differentiation of anxiety: An EEG-based comparative study of panic disorder and major depressive disorder","authors":"Seok-Im Lee ,&nbsp;Joon Hwan Jang ,&nbsp;Jung-Seok Choi ,&nbsp;Hee Yeon Jung ,&nbsp;Jun-Young Lee ,&nbsp;So Young Yoo","doi":"10.1016/j.jad.2025.119748","DOIUrl":"10.1016/j.jad.2025.119748","url":null,"abstract":"<div><h3>Background</h3><div>Panic disorder (PD) and major depressive disorder (MDD) frequently co-occur, leading to poorer prognosis. Although anxiety symptoms in both conditions appear similar, their underlying mechanisms may differ, as indicated by shared and distinct features in theoretical models and neurophysiological findings. This study investigates EEG-based neural differentiation of anxiety between PD and MDD, integrating the Tripartite Model and Five-Factor Structure.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed resting-state electroencephalographic (EEG) data from 75 participants (PD: <em>n</em> = 35; MDD: <em>n</em> = 40). Generalized estimating equations examined group differences in EEG absolute power (μV²) and asymmetry across frontal, central, and posterior regions. These differences were assessed in relation to factors associated with Anxious Arousal and Negative Affect from the Five-Factor Structure, measured via the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), across five frequency bands (delta, theta, alpha, beta, gamma). Additional analyses explored subregional differences in temporal, parietal, and occipital areas.</div></div><div><h3>Results</h3><div>While Anxious Arousal showed no distinct neural patterns, Negative Affect revealed significant group differences in posterior beta-band asymmetry. In the posterior temporal region, the PD group exhibited increased rightward asymmetry, whereas the MDD group showed decreased rightward asymmetry. Significant group differences in posterior parietal asymmetry were also observed for Negative Affect, but these contrasting trends were not significant.</div></div><div><h3>Conclusions</h3><div>The distinct neurophysiological patterns for Negative Affect observed between PD and MDD may serve as potential neurobiological markers and support the exploration of treatment neuromodulation strategies targeting specific neural circuits, particularly in posterior brain regions, to alleviate anxiety symptoms.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119748"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of multi-omics and crowdsourcing assessment of placenta-brain axis biomarkers for predicting neurodevelopmental disorders","authors":"Yimin Zhang ,&nbsp;Heyue Jin ,&nbsp;Juan Tong ,&nbsp;Hong Gan ,&nbsp;Fangbiao Tao ,&nbsp;Yumin Zhu","doi":"10.1016/j.jad.2025.119732","DOIUrl":"10.1016/j.jad.2025.119732","url":null,"abstract":"<div><div>Neurodevelopmental disorders (NDDs) are heterogeneous and multifactorial psychiatric disorders with abnormalities in multiple biological domains. It is increasingly recognized that the placenta profoundly influences fetal neurodevelopment due to the finding of the placenta-brain axis. However, few studies have investigated the interplay between placenta dysfunction and NDDs, especially autism spectrum disorder (ASD) symptoms, attention-deficit/hyperactivity disorder (ADHD) symptoms, and intellectual disability (ID) symptoms, by using integrative multi-omics data. Here, we performed an analysis of transcriptomic and non-targeted metabolomic individually and integratively to characterize the placental multi-omics profiles of children with NDDs in Ma'anshan Birth Cohort, and to identify biomarkers associated with the placenta-brain axis. Integrating transcriptome and metabolome perspectives, we further conducted a multi-omics machine learning workflow to discover reliable placental biomarkers for early diagnosis of these NDDs in the participants. Integrative analysis of differentially expressed genes and metabolites revealed a common intrauterine regulation mechanism for ASD symptoms and ADHD symptoms. Combined with machine learning, prediction models were constructed and 99.7 % of ASD symptoms, 99.0 % of ADHD symptoms, and 95.7 % of ID symptoms were correctly classified. This is the first study combining transcriptomics and metabolomics from the perspective of the placental-brain axis in humans, which contributes to a deeper understanding about the pathogenesis of the NDDs and may potentially pave the way toward molecular diagnosis of different disorders.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119732"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of dietary habits, inflammatory dietary index, and lifestyle factors with depressive symptoms: A cross-sectional study of 53,539 individuals with thyroid nodules","authors":"Lijun Li ,&nbsp;Ying Li ,&nbsp;Hui Li ,&nbsp;Yi Zhou ,&nbsp;Xue He ,&nbsp;Pingting Yang ,&nbsp;Xingxing Wang ,&nbsp;Jiayi Zhu ,&nbsp;Yinglong Duan ,&nbsp;Jianfei Xie ,&nbsp;Andy S.K. Cheng","doi":"10.1016/j.jad.2025.119735","DOIUrl":"10.1016/j.jad.2025.119735","url":null,"abstract":"<div><h3>Background</h3><div>Depressive symptoms are closely associated with thyroid nodules (TNs). Lifestyle and dietary factors have been linked to depressive symptoms. Therefore, this study aimed to investigate the associations between dietary patterns-including dietary diversity, protein-enriched dietary, inflammatory dietary patterns, dietary habits and depressive symptoms in individuals with TNs.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 53,539 participants who underwent physical examinations between January 2017 and March 2024. Participants completed self-reported questionnaires on demographic characteristics, physical health, activity levels, dietary index scores, dietary habits, and depressive symptoms.</div></div><div><h3>Results</h3><div>Participants were female (OR: 1.38, 95 % CI: 1.30–1.46), divorced or widowed (OR: 1.56, 95 % CI: 1.31–1.85), had a higher waist-hip ratio, and (OR: 2.22; 95 % CI: 1.43–3.43) and engaged in prolonged sedentary time (OR: 1.51; 95 % CI: 1.41–1.62) were more likely to report depressive symptoms. Regarding dietary factors, an anti-inflammatory dietary (OR: 0.79; 95 % CI: 0.75–0.83) and a protein-enriched dietary (OR: 0.87; 95 % CI: 0.83–0.92) were associated with a lower risk of depressive symptoms. However, irregular eating (OR: 2.00, 95 % CI: 1.81–2.21), overeating frequently (OR: 1.87; 95 % CI: 1.70–2.05), and being a former drinker (OR: 1.43, 95 % CI: 1.19–1.71) were associated with a higher risk of depressive symptoms in individuals with TNs.</div></div><div><h3>Conclusions</h3><div>Unhealthy eating behaviors and prolonged sedentary time were associated with a higher risk of depressive symptoms in individuals with TNs, while anti-inflammatory and protein-rich diets were associated with lower odds. These findings suggest potential links between dietary and lifestyle factors and depressive symptoms, which may warrant further investigation in prospective or interventional studies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119735"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Is 'minimally adequate treatment' really adequate? investigating the effect of mental health treatment on quality of life for children with mental health problems\" [J. Affect. Disord. 276 (2020) 327-334].","authors":"Jemimah Ride, Li Huang, Melissa Mulraney, Harriet Hiscock, David Coghill, Michael Sawyer, Emma Sciberras, Kim Dalziel","doi":"10.1016/j.jad.2025.119691","DOIUrl":"10.1016/j.jad.2025.119691","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119691"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}