Journal of affective disorders最新文献

{"title":"Longitudinal changes in neurocognitive functioning over two years in young people at increased genetic risk of bipolar disorder.","authors":"M Budiarto, M J Green, C Cignarello, P B Mitchell, G Roberts","doi":"10.1016/j.jad.2025.119910","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119910","url":null,"abstract":"<p><strong>Background: </strong>Deficits in neurocognitive abilities are present in individuals with bipolar disorder (BD) and their unaffected first-degree relatives. However, limited research has examined changes in neurocognitive deficits over time in young people at increased genetic risk of BD.</p><p><strong>Method: </strong>Neurocognition was evaluated at baseline in 180 young unaffected individuals (aged 12-30 years) at high familial risk of BD (HR), 70 patients with BD, and 130 controls. After two-year follow-up, neurocognition was reassessed in 132 HR participants and 102 controls.</p><p><strong>Results: </strong>At baseline, the HR and BD groups demonstrated deficits in response inhibition and attention relative to controls. Over the follow-up period, baseline impairments in the Affective Go/No-Go task in the HR group remained persistent except for errors of omission towards positive valence stimuli, where impairment found at baseline improved over time, relative to controls (P = 0.001). During response inhibition to negative stimuli, HR participants who developed BD showed an impairment at baseline but improved over time, relative to those HR subjects who remained well and controls (P = 0.025); this effect was more pronounced in those who converted to threshold BD.</p><p><strong>Limitations: </strong>While our study is well powered for whole group comparisons, the HR sub-group analyses were under-powered.</p><p><strong>Conclusion: </strong>Neurocognitive baseline impairments in HR individuals remained largely persistent over time, with one response inhibition condition showing some improvement over time in those who developed BD. Our findings highlight the importance of stratifying HR cohorts and suggest impaired response inhibition may represent a quantitative endophenotype that differentiates those who transition to BD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119910"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subthreshold manic symptoms as a risk factor for depressive, anxiety and substance use: Results of a prospective study in the general population.","authors":"Rosalie A L Beekman, Margreet Ten Have, Ron de Graaf, Ralph W Kupka, Eline J Regeer","doi":"10.1016/j.jad.2025.119873","DOIUrl":"10.1016/j.jad.2025.119873","url":null,"abstract":"<p><strong>Background: </strong>Indicated prevention aimed at high-risk individuals with subthreshold psychiatric symptoms should alleviate the disease burden caused by depressive, anxiety, and substance use disorders (further called: common mental disorders, CMD). This study investigates subthreshold manic symptoms (subM) as a possible risk factor for CMD and, for comparison, bipolar disorder type I and II (BD).</p><p><strong>Methods: </strong>We assessed three-year manifestation of CMD and onset of BD in an adult cohort (n = 4618) representative of the Dutch general population. SubM was defined as elevated mood or irritability lasting at least four days, without meeting DSM-IV criteria for BD. Manifest CMD were absent at baseline and present in the subsequent three years, irrespective of lifetime occurrence (manifestation = onset and recurrence). Onset BD was absent at lifetime and baseline and present in the subsequent three years.</p><p><strong>Results: </strong>Individuals with subM had a significantly increased risk of manifest depressive (odds ratio (OR) 2.3-2.9; p for trend < 0.001) and anxiety disorders (1.5-5.9; <0.001) and of onset BD (6.4-43.8; <0.001), but not of substance use disorders, as compared to those without manic symptoms. BD risk was elevated strongest. Increased risks persisted after adjustment for sociodemographic variables, presence of other CMD and lifestyle factors.</p><p><strong>Conclusions: </strong>SubM precedes forthcoming depressive, anxiety and bipolar disorders on short term. Their presence should be considered a relevant predictor in the psychopathological pathway of mood- and anxiety disorders. Moreover, we recommend to include subM in research on risk prediction tools and preventive interventions for mood- and anxiety disorders.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119873"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of 'weekend warrior' physical activity pattern and depressive symptoms.","authors":"Eduardo Rossato de Victo, Rafael Mathias Pitta, Gerson Ferrari, Felipe Barreto Schuch, Luana de Lima Queiroga, Oskar Kaufmann, Nelson Wolosker","doi":"10.1016/j.jad.2025.119911","DOIUrl":"10.1016/j.jad.2025.119911","url":null,"abstract":"<p><strong>Background: </strong>Physical activity (PA) is recognized as a protective factor against depressive symptoms; however, the role of different PA patterns remains unclear. This study aimed to investigate the association between the \"weekend warrior\" PA pattern and depressive symptoms in the Brazilian population, with analyses stratified by sex and obesity status.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 29,907 individuals aged 18 and older who underwent screening exams between 2008 and 2022 at a Brazilian hospital. PA was assessed using the long form of the International Physical Activity Questionnaire. Participants were grouped into three PA patterns: Not meeting PA recommendation (<150 min/week of moderate-to-vigorous PA), weekend warrior (≥150 min/week concentrated on 1-2 days), and regularly active (≥150 min/week on ≥3 days). Depressive symptoms were defined as a Beck Depression Inventory-II score ≥ 14. Logistic regression tested the associations in an unadjusted model and three adjusted models, controlling for sociodemographic, behavioral, and clinical variables.</p><p><strong>Results: </strong>The prevalence of depressive symptoms among participants was 10.4 %. The weekend warrior PA pattern was not associated with depressive symptoms. The regularly active PA pattern was associated with a lower likelihood of depressive symptoms (OR: 0.56; 95%CI: 0.52-0.61), and this association remained significant after adjustment across different models (OR: 0.68; 95%CI: 0.62-0.75). In the stratified analyses, no association was found between the weekend warrior PA pattern and depressive symptoms.</p><p><strong>Conclusion: </strong>The weekend warrior PA pattern was not associated with depressive symptoms, while the regularly active pattern was associated with lower odds, regardless of sex or obesity status.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119911"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of metabolic heterogeneity of obesity with depression progression among middle-aged and older adults in China: A prospective study.","authors":"Li Huang, Chengcheng Liao, Zhenzhen Liang, Huajian Chen","doi":"10.1016/j.jad.2025.119875","DOIUrl":"10.1016/j.jad.2025.119875","url":null,"abstract":"<p><strong>Background: </strong>In previous studies, there have been few studies focusing on the association between metabolic heterogeneity of obesity and depression. The association between metabolic heterogeneity of obesity and depression progression remains unclear.</p><p><strong>Methods: </strong>This study used data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018. Metabolic heterogeneity of obesity was assessed according to four obesity and metabolic statuses, namely metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy overweight/obesity (MHOO) and metabolically unhealthy overweight/obesity (MUOO). Linear mixed-effects models were used to analyze the association between metabolic heterogeneity of obesity and depression progression.</p><p><strong>Results: </strong>After 7 years of follow-up, MUNW, MHOO, and MUOO showed accelerated depression progression compared with MHNW, with additional annual increases of 0.09 (95 % CI: 0.02 to 0.17), 0.12 (95 % CI: 0.03 to 0.20), and 0.10 (95 % CI: 0.04 to 0.17). Participants with stable MUNW, MHOO, MUOO, MHNW transition to MUNW, and weight change in metabolically abnormal states exhibited accelerated depression progression compared to stable MHNW. And accelerated depression progression was significant in MUNW, MHOO, and MUOO among participants without social activities.</p><p><strong>Conclusions: </strong>Although MUNW, MHOO, and MUOO exhibited milder depressive symptoms at baseline compared to MHNW, these phenotypes were associated with an accelerated depression progression over time. Additionally, social activities can mitigate the acceleration of depression progression. Our findings highlighted the important role of obesity and metabolic status and their shifts in the depression progression in middle-aged and older adults, and emphasized the buffering role of positive social activities.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119875"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Neurofilament Polypeptide Level in Patients with Bipolar Disorder and its Effect on Cognitive Functioning.","authors":"Elif Nur Donbaloğlu, Halil Özcan, Mehmet Ali Donbaloğlu, Ahmet Kızıltunç, Esra Eğilmez","doi":"10.1016/j.jad.2025.119921","DOIUrl":"10.1016/j.jad.2025.119921","url":null,"abstract":"<p><strong>Background: </strong>Elevated neurofilaments in serum are thought to be an indicator of neurodegeneration in bipolar disorder (BD). In our study, we evaluated serum neurofilament light chain (NF-L), medium chain (NF-M) and heavy chain (NF-H) levels in manic, depressive and euthymic phases of BD by ELISA method and investigated the relationship of these levels with neuropsychological functions by CNSVS (Central Nervous System Vital Signs).</p><p><strong>Method: </strong>Patients with manic, depressive and remission periods, aged between 18 and 50, diagnosed with BD according to DSM-5, and healthy volunteers were included in the study. The sociodemographic-clinical data form, clinical scales and CNSVS tests were applied to the participants. Serum values of NF-L, NF-M and NF-H were measured by ELISA method.</p><p><strong>Results: </strong>Mean NF-L, NF-M and NF-H levels showed significant differences between the patient and control groups (p < 0.001). When neurofilament levels and neurocognitive domains were evaluated in bipolar patients; NF-M and NF-H levels showed a negative correlation with NCI, composite memory, verbal and visual memory, cognitive flexibility, executive functions, psychomotor speed.</p><p><strong>Conclusion: </strong>Elevated neurofilament polypeptide levels during all stages of BD compared to controls may be an indicator of inflammatory-mediated axonal damage in bipolar patients and might be used as a biomarker for neurodegeneration in BD. CNSVS neuropsychological test battery has an important place in determining the neurocognitive dysfunctions in individuals with BD. Negative correlation detected between serum NF-M and NF-H levels and cognitive test performance might reflect the neurodegeneration related poor cognitive performance.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119921"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between childhood receptive vocabulary and suicide attempt during adolescence and young adulthood.","authors":"Jovia Hin Lam Wong, Sînziana-Ioana Oncioiu, Lisa-Christine Girard, Jean R Séguin, Sylvana M Côté, Richard E Tremblay, Michel Boivin, Marie-Claude Geoffroy, Massimiliano Orri","doi":"10.1016/j.jad.2025.119930","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119930","url":null,"abstract":"<p><strong>Background: </strong>Children's language skills are key to good socioemotional development. Higher childhood receptive language scores were associated with lower internalizing behavioural problems, but little is known about associations with later suicide risk. We investigated associations between childhood receptive vocabulary and youth suicide attempt.</p><p><strong>Methods: </strong>Date were from the Quebec Longitudinal Study of Child Development (n = 1631). Childhood receptive vocabulary was assessed at ages 3.5, 5, 6, and 10 years using the Peabody Picture Vocabulary Test-Revised. Suicide attempt was self-reported between ages 13 to 23 years. Univariable and multivariable analyses were conducted to investigate the associations between receptive vocabulary scores and suicide attempt while accounting for the role of sex (interaction analysis).</p><p><strong>Results: </strong>Associations between receptive vocabulary scores and suicide attempt varied depending on both child sex and age (p_interactions = 0.022-0.120 at ages 3.5-10). In females, higher receptive vocabulary scores at age 3.5 was associated with decreased odds of attempting suicide, OR = 0.82, 95%CI [0.68,0.99], even after covariates adjustment, OR = 0.84, 95%CI [0.68,1.02]. Receptive vocabulary scores at ages 5 and 6 were associated with suicide attempt, but only before covariate adjustment. In males, no associations were found between receptive vocabulary scores at ages 3.5, 5, or 6 and suicide attempt. Male receptive vocabulary scores at age 10 years were associated with a higher likelihood of reporting suicide attempt, although this did not reach conventional levels of statistical significance.</p><p><strong>Limitations: </strong>Attrition limits generalizability of findings.</p><p><strong>Conclusions: </strong>These results emphasize the potential role of childhood receptive vocabulary skills as a vulnerability marker for youth suicide attempt risk.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119930"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Momentary dynamics of intimate partner violence and posttraumatic stress symptoms among women: The influence of positive emotion dysregulation","authors":"Alexa M. Raudales ,&nbsp;Gemma T. Wallace ,&nbsp;Reina Kiefer ,&nbsp;Leslie A. Brick ,&nbsp;Heather T. Schatten ,&nbsp;Nicole H. Weiss","doi":"10.1016/j.jad.2025.119928","DOIUrl":"10.1016/j.jad.2025.119928","url":null,"abstract":"<div><h3>Objective</h3><div>Posttraumatic stress symptoms (PTSS) among women experiencing intimate partner violence (IPV) are a major public health burden. Yet, there is a need to better understand how IPV and PTSS relate over time. One understudied factor that may influence the IPV-PTSS association is dysregulation stemming from positive emotions. The objective of the current study was to clarify the temporal dynamics between IPV types (psychological, physical, sexual) and PTSS as well as the influence of positive emotion dysregulation.</div></div><div><h3>Methods</h3><div>Participants were 145 women recruited from the community (<em>M</em>_<em>age</em> = 40.66, 40.7 % white) experiencing IPV and using any amount of alcohol or drugs who completed a baseline session and three daily surveys for 30 days. A multi-level dynamic structural equation modeling analysis was tested.</div></div><div><h3>Results</h3><div>At the within-person level, significant cross-lagged effects were found for IPV predicting next-interval PTSS for psychological (Standardized Fixed Effect Estimate = 0.27, 95 % <em>CI</em>[0.02, 0.61]) and physical (Standardized Fixed Effect Estimate = 0.61, 95 % <em>CI</em>[0.22, 1.14]) IPV, but not sexual IPV. At the between-person level, baseline positive emotion dysregulation was significantly associated with the random cross-lagged effect for IPV and next-interval PTSS for sexual IPV (Standardized Fixed Effect Estimate = 0.29, 95 % <em>CI</em>[0.02, 0.52]), but not psychological or physical IPV.</div></div><div><h3>Conclusion</h3><div>Findings shed light on how IPV across types perpetuates PTSS in the daily lived experiences of women who experience IPV and use substances and underscore a significant influence of positive emotion dysregulation.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119928"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathways to better sleep: Depression, anxiety, and stress as mediators in the relationship between social support and insomnia severity in Appalachian adults","authors":"Mairead E. Moloney ,&nbsp;Emily Slade ,&nbsp;Joon Chung ,&nbsp;Kory Heier ,&nbsp;Daniela C. Moga","doi":"10.1016/j.jad.2025.119929","DOIUrl":"10.1016/j.jad.2025.119929","url":null,"abstract":"<div><h3>Background</h3><div>Rural Appalachia has some the highest rates of sleep and health disparities in the United States.</div><div>This study investigates the relationship between social support and insomnia severity in rural Appalachian adults, with specific attention to the potential mediating roles of depression, anxiety, and stress.</div></div><div><h3>Methods</h3><div>Participants from 12 rural Eastern Kentucky counties completed validated measures of insomnia severity, social support, depression, anxiety, and perceived stress. Using R, we calculated descriptive statistics and fit mediation models for depressive symptoms, anxiety symptoms, and stress, with social support as the exposure and insomnia severity as the outcome.</div></div><div><h3>Results</h3><div>Aligning with regional demographics, nearly all participants identified as Caucasian/White (97.4 %) and non-Hispanic/non-Latin (a/o)/non-Latinx (96.8 %). Of 270 participants (mean age: 46 [SD = 13.2], 79.9 % women) 30 % had clinically significant insomnia. Greater social support was associated with lower insomnia severity (<em>r</em> = −0.30, <em>p</em> &lt; 0.001) in unadjusted analyses. Mediation analyses revealed that this relationship was significantly mediated by depressive symptoms (69 %), anxiety symptoms (64 %), and perceived stress (78 %). After accounting for these psychological mediators, the direct effect of social support on insomnia was no longer significant.</div></div><div><h3>Conclusions</h3><div>Our findings provide valuable insight into the psychological mechanisms linking social support and sleep health in rural Appalachian adults, though generalizability may be limited to similar racially homogeneous, rural populations. Social support influences insomnia symptoms in rural Appalachian adults primarily through psychological pathways, particularly by buffering against stress. Interventions addressing sleep problems in this population should target psychological factors while leveraging existing social resources within the cultural context of Appalachia.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119929"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An updated systematic review and meta-analysis of the predictive validity of the general anxiety disorder (GAD)-7 and GAD-2 in screening for anxiety disorders","authors":"Seong-Hi Park ,&nbsp;Sun Kyung Park","doi":"10.1016/j.jad.2025.119913","DOIUrl":"10.1016/j.jad.2025.119913","url":null,"abstract":"<div><h3>Background</h3><div>This study was an updated systematic review and meta-analysis to examine the validity of the general anxiety disorder (GAD)-7 and GAD-2 for GAD and other anxiety disorders.</div></div><div><h3>Methods</h3><div>Electronic searches were performed using MEDLINE, EMBASE, CINAHL, and PsycArticles databases. This review compared the predictive validity of the GAD-7, GAD-2, and other anxiety screening tools and conducted a subgroup analysis based on the GAD-7 according to the target anxiety and participant characteristics.</div></div><div><h3>Results</h3><div>In total, 45 studies were selected based on the inclusion criteria. The sensitivity of GAD-7 (43 studies) was 0.81 (95 % CI, 0.78–0.84), specificity was 0.78 (95 % CI, 0.74–0.81), and sROC AUC was 0.87. For GAD-2 (13 studies), the sensitivity was 0.78 (95 % CI, 0.73–0.83), specificity was 0.81 (95 % CI, 0.73–0.86), and sROC AUC was 0.86. For other anxiety screening tools (seven studies) the sensitivity was 0.78 (95 % CI, 0.74–0.82), specificity was 0.81 (95 % CI, 0.74–0.86), sROC AUC was 0.86. In the subgroup analysis according to anxiety targets, when measuring GAD alone, the sensitivity and specificity of GAD-7 were higher than those of other anxiety disorders, with an sROC AUC of 0.88 versus 0.84. In the subgroup analysis of the participants, the sensitivity in patients with epilepsy was 0.89, which was higher than that in other participants.</div></div><div><h3>Conclusions</h3><div>This study demonstrated that the GAD-7 had adequate diagnostic accuracy, suggesting that it can help screen patients with anxiety disorders. Moreover, the GAD-7 has a high screening validity for anxiety in patients with epilepsy.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119913"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conspiratorial thinking in a 50-state survey of American adults.","authors":"Roy H Perlis, Ata Uslu, Sergio A Barroilhet, Paul A Vohringer, Anudeepa K Ramachandiran, Mauricio Santillana, Matthew A Baum, James N Druckman, Katherine Ognyanova, David Lazer","doi":"10.1016/j.jad.2025.119915","DOIUrl":"10.1016/j.jad.2025.119915","url":null,"abstract":"<p><p>Conspiratorial thoughts as a cognitive aspect are understudied outside small clinical cohorts. We conducted a 50-state non-probability internet survey of respondents age 18 and older, who completed the American Conspiratorial Thinking Scale (ACTS) and the 9-item Patient Health Questionnaire (PHQ-9). Across the 6 survey waves, there were 123,781 unique individuals. After reweighting, a total of 78.6 % somewhat or strongly agreed with at least one conspiratorial idea; 19.0 % agreed with all four of them. More conspiratorial thoughts were reported among those age 25-54, males, individuals who finished high school but did not start or complete college, and those with greater levels of depressive symptoms. Endorsing more conspiratorial thoughts was associated with a significantly lower likelihood of being vaccinated against COVID-19. The extent of correlation with non-vaccination suggests the importance of considering such thinking in designing public health strategies.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119915"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}