Journal of affective disorders最新文献

{"title":"Hospital admissions for anxiety disorder, depression, and bipolar disorder and venous thromboembolism: A UK biobank prospective cohort study.","authors":"Shinya Nakada, Carlos Celis-Morales, Jill P Pell, Frederick K Ho","doi":"10.1016/j.jad.2024.12.060","DOIUrl":"10.1016/j.jad.2024.12.060","url":null,"abstract":"<p><strong>Background: </strong>Few studies have investigated whether and which anxiety and affective disorders are associated with the risk of venous thromboembolism. We aimed to examine whether anxiety disorder, depression, and bipolar disorder increase the risk of venous thromboembolism, independent of socioeconomic confounders and each other, in a UK general population.</p><p><strong>Methods: </strong>This is a prospective cohort study using UK Biobank. Participants were excluded if they were diagnosed with venous thromboembolism before the baseline assessment, if they were first diagnosed with anxiety disorder, depression, or bipolar disorder thereafter, or if they had missing sociodemographic data. Diagnosed anxiety disorder, depression, and bipolar disorder were ascertained through hospital admission data and incident venous thromboembolism, pulmonary embolism, and deep vein embolism were ascertained through both hospital admission and death certificate data. Hazard ratios were calculated, adjusted for sociodemographic confounders and comorbid anxiety and affective disorders.</p><p><strong>Results: </strong>Our main analysis included 455,705 participants, of whom 53.6 % were female, with a mean age (standard deviation) of 56.6 (8.1) years. Anxiety disorder, depression, and bipolar disorder were associated with venous thromboembolism both before and after adjusting for sociodemographic confounders. After adjustment for comorbid anxiety and affective disorders, depression (HR: 2.00; 95 % CI: 1.68-2.38) and bipolar disorder (HR: 2.08; 95 % CI: 1.28-3.37) remained associated with venous thromboembolism, but anxiety did not (HR: 1.17; 95 % CI: 0.88-1.57). Similar results were found for pulmonary embolism and deep vein embolism.</p><p><strong>Conclusions: </strong>Depression and bipolar disorder were associated with the risk of venous thromboembolism. Further research is required to understand the mechanism underlying their increased risk.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"564-571"},"PeriodicalIF":4.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic and clinical burden of major depressive disorder with insomnia symptoms in commercially and medicaid-insured adults in the United States: A retrospective matched cohort study.","authors":"Hrishikesh Kale, Maryia Zhdanava, Dominic Pilon, John Sheehan, Tiina Drissen, Porpong Boonmak, Zia Choudhry, Aditi Shah, Manish K Jha","doi":"10.1016/j.jad.2024.12.048","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.048","url":null,"abstract":"<p><strong>Background: </strong>Insomnia is a common symptom of major depressive disorder (MDD). Presence of insomnia symptoms in MDD (MDDIS) has been associated with worse depression severity and outcomes. This study assessed the economic and clinical burden of MDDIS in the United States.</p><p><strong>Methods: </strong>Commercially and Medicaid-insured adults from Merative® MarketScan® Databases (01/2016-06/2021) with ≥1 MDD diagnosis (index date) were included in the MDDIS cohort if they had ≥1 insomnia diagnosis within 12 month afterwards or in the other MDD cohort if they had no insomnia diagnoses/treatments; patients without MDD diagnoses/treatments (random index date) were included in the non-MDD cohort. Cohorts were propensity score-matched. Healthcare resource use (HRU), costs, and treatment patterns 12 months post-index were compared between MDDIS and each control cohort using linear and Poisson regressions.</p><p><strong>Results: </strong>In both commercially (N = 52,280; mean age: 44 years; 67 % female) and Medicaid-insured (N = 15,653; mean age: 41 years; 73 % female) populations, the MDDIS cohort had significantly higher HRU and cost than the other MDD and non-MDD cohorts. Mean total all-cause healthcare cost difference between the MDDIS and other MDD cohort was $5842 (commercial) and $5152 (Medicaid); between the MDDIS and non-MDD cohort, it was $14,266 (commercial) and $11,314 (Medicaid). MDDIS compared to other MDD was associated with higher use of antidepressants, particularly agents with sedative effect.</p><p><strong>Limitations: </strong>Data are subject to incompleteness that might lead to measurement biases.</p><p><strong>Conclusions: </strong>MDDIS compared to other MDD and non-MDD was associated with significantly higher economic and clinical burden, highlighting the need for effective treatments for this population.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to maintain recovery following low-intensity interventions for anxiety and/or depression? A qualitative exploration through perspectives of professionals and stakeholders.","authors":"Saher Nawaz, Penny Bee, Cintia Faija","doi":"10.1016/j.jad.2024.12.054","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.054","url":null,"abstract":"<p><strong>Background: </strong>Globally, 301 million people have anxiety disorders and 280 million have depression. Talking therapies are the preferred option against pharmacological treatment for these populations. In the UK, over half of those who received low-intensity evidence-based talking therapy for anxiety and/or depression relapsed within a year. This study explored practitioners and stakeholders' perspectives on current practices routinely use to maintain recovery over time and identified opportunities to improve long-term treatment effectiveness in NHS Talking Therapies services.</p><p><strong>Methods: </strong>This is a qualitative study using semi-structured interviews. Twenty-five participants were interviewed remotely. Data were analysed deductively using the Consolidated Framework for Implementation Research (CFIR) and inductively to allow emerging codes that did not map into the framework.</p><p><strong>Results: </strong>Of the 36 CFIR domains, 27 were evidenced in the data, and 17 new constructs were developed. Data emphasised the absence of standardised approaches in addressing relapse prevention, limitations on available resources, the need for further training, the importance of defining recovery beyond clinical symptoms, and recommendations were identified to support recovery over time.</p><p><strong>Limitations: </strong>The sample comprised primarily White British females, reflecting the current workforce. Those interested in participating may have resulted in social desirability biases. Furthermore, focussing on professional perspectives may not represent service user experiences.</p><p><strong>Conclusions: </strong>All participants agreed on the importance of interventions targeting recovery over time and emphasised the need for effective training and resources to support professionals and patients in sustaining treatment gains over time. Cost-effective interventions targeting long-term recovery could prove fruitful to improve current provision.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mentalizing, epistemic trust and interpersonal problems in emotion regulation: A sequential path analysis across common mental health disorders and community control samples.","authors":"Güler Beril Kumpasoğlu, Rob Saunders, Chloe Campbell, Tobias Nolte, Read Montague, Steve Pilling, Judy Leibowitz, Peter Fonagy","doi":"10.1016/j.jad.2024.12.050","DOIUrl":"10.1016/j.jad.2024.12.050","url":null,"abstract":"<p><strong>Background: </strong>Emotion regulation is a crucial function implicated in multiple mental health disorders; understanding the mechanisms by which emotion regulation has such impact is essential. Mentalizing has been posited as a prerequisite for effective emotion regulation. The current study aims to examine the roles of epistemic trust and interpersonal problems in driving the association between mentalizing and emotion regulation, contrasting clinical and non-clinical populations.</p><p><strong>Method: </strong>A total of 652 individuals (296 clinical and 356 community control) were employed. Sequential mediation analysis was used to examine the role of epistemic stances and interpersonal problems in the mentalizing-emotion regulation link, and moderated mediation analysis was conducted to identify group differences in these pathways.</p><p><strong>Results: </strong>Ineffective mentalizing was associated with emotion dysregulation and interpersonal problems. Higher levels of epistemic credulity and mistrust were associated with ineffective mentalizing, interpersonal problems, and emotion dysregulation. Sequential mediation analysis indicated that disruptions in epistemic trust (epistemic mistrust and credulity) and interpersonal problems partially mediated the relationship between inadequate mentalizing and emotion dysregulation, with these pathways being consistent across both clinical and control groups. The pathways including epistemic trust were not significant.</p><p><strong>Limitations: </strong>The study's limitations include a simplified theoretical model, a cross-sectional design preventing causal inference, and sample recruitment methods possibly limiting generalizability.</p><p><strong>Conclusions: </strong>These findings suggest a potential mechanism connecting mentalizing, disruptions in epistemic trust, interpersonal problems, and emotion regulation, to illuminate a crucial aspect of psychological functioning. These results emphasize the significance of social-communicative aspect in clinical outcomes.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"502-511"},"PeriodicalIF":4.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter changes in paediatric bipolar disorder: A systematic review of diffusion magnetic resonance imaging studies.","authors":"Iman Kiani, Mohammad Hadi Aarabi, Giulia Cattarinussi, Fabio Sambataro, Virginia Favalli, Chiara Moltrasio, Giuseppe Delvecchio","doi":"10.1016/j.jad.2024.12.042","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.042","url":null,"abstract":"<p><strong>Background: </strong>Paediatric bipolar disorder (PBD) is characterized by severe mood fluctuations that deviate from typical childhood emotional development. Despite the efforts, the pathophysiology of this disorder is not well understood yet. In this review, we aimed to synthesize existing diffusion magnetic resonance imaging (dMRI) research findings focused on PBD.</p><p><strong>Methods: </strong>A literature search was conducted using PubMed, Embase, Scopus, and Web of Science databases to identify relevant studies published before April 2024.</p><p><strong>Results: </strong>A total of 23 studies met the inclusion criteria and were included in the review. The findings showed variations in fractional anisotropy (FA), axial diffusivity, radial diffusivity, and apparent diffusion coefficient in PBD patients compared to healthy controls (HC). Key findings included decreased FA in the anterior cingulate, anterior corona radiata, and corpus callosum, whose subregion, namely the genu of corpus callosum, was found to be correlated with clinical symptoms. Furthermore, longitudinal studies emphasized the significance of the uncinate fasciculus as having atypical developmental trajectories in PBD patients. In addition, graph analysis revealed widespread changes in structural connectivity, especially affecting the orbitofrontal cortex, frontal gyrus and basal ganglia. Lastly, machine learning models showed promising results in differentiating PBD from HC.</p><p><strong>Limitations: </strong>Cross-sectional studies, small sample sizes, and different imaging protocols preclude integration of findings.</p><p><strong>Conclusion: </strong>PBD shows to be associated with widespread structural changes compared to HC. Since these changes might be accountable for the clinical manifestations of this disorder, increase our understanding on the neurobiological underpinnings of PBD may help the identification of more effective treatments.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived stress mediates the longitudinal effect of sleep quality on internalizing symptoms.","authors":"Runtang Meng, Jiale Xu, Yi Luo, Stefanos Mastrotheodoros, Chen Jiang, Carlo Garofalo, Claudia Mazzeschi, Tine Nielsen, Daniel Yee Tak Fong, Joseph M Dzierzewski, Haiyan Ma, Karen Spruyt, Oliviero Bruni","doi":"10.1016/j.jad.2024.12.046","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.046","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies have explored the relationship between sleep quality and internalizing symptoms (i.e., depression and anxiety), but there is uncertainty about their directional pathways. Here, we investigated the longitudinal associations between sleep quality and internalizing symptoms and tested the potential mediation effect of perceived stress.</p><p><strong>Methods: </strong>A longitudinal survey of Chinese healthcare students (N = 343) was conducted at three time points: Time 1 (baseline), Time 2 (1 week later), and Time 3 (3 weeks after Time 2). Participants completed the Sleep Quality Questionnaire (SQQ), Perceived Stress Questionnaire-30 (PSQ-30), and the Patient Health Questionnaire-4 (PHQ-4) at each time point, where each asked about participants' experiences over the past week. A higher SQQ score indicated poorer sleep quality, while higher scores on the PHQ-4 and PSQ-30 indicated more severe internalizing symptoms and perceived stress. Using autoregressive cross-lagged panel modeling (CLPM), we examined the bidirectional relationships among sleep quality, internalizing symptoms, and perceived stress.</p><p><strong>Results: </strong>CLPM revealed that baseline sleep quality negatively predicted subsequent changes in internalizing symptoms, and vice versa. While perceived stress mediated the relationship between sleep quality and internalizing symptoms at the 3-week follow-up (β = 0.017, p = .038), it did not mediate the reverse relationship between internalizing symptoms and sleep quality.</p><p><strong>Conclusions: </strong>There was a negative bidirectional relationship between sleep quality and internalizing symptoms. Furthermore, perceived stress mediated the effect of poor sleep quality on internalizing symptoms, suggesting that good-quality sleep may enhance stress resilience and alleviate symptoms of depression and anxiety, thereby improving overall wellbeing.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychedelic use and bipolar disorder - An investigation of recreational use and its impact on mental health.","authors":"Thomas D Meyer, Maya Ibrahim, Lauren Vale, Jair C Soares","doi":"10.1016/j.jad.2024.12.044","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.044","url":null,"abstract":"<p><p>Psychedelic substances such as psilocybin have recently gained attention for their potential therapeutic benefits in treating depression and other mental health problems. However, individuals with bipolar disorder (BD) have been excluded from most clinical trials due to concerns about manic switches or psychosis. This study aimed to systematically examine the effects of recreational psychedelic use in individuals with BD. Using the Time-Line Follow Back (TLFB) method, we assessed mood symptoms, substance use, and other mental health-related variables in the month before and three months following participants' most recent psychedelic experience. Results showed a significant reduction in depressive symptoms and cannabis use, an increase in the number of days without mental health symptoms, and an increase in the number of days with hallucinogen use. Importantly, no significant changes in (hypo)manic, psychotic, or anxiety symptoms were observed. These findings suggest that psychedelics may hold potential as a safe and effective treatment for BD, though further research, including randomized controlled trials, is needed.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demoralization's link to depression and anxiety symptoms: A network analysis.","authors":"Markus Ramm, Kathrin Schnabel, Johanna Jedamzik, Lara Jürgens, Miriam Rassenhofer, Elmar Brähler, Gereon Heuft, Rupert Conrad","doi":"10.1016/j.jad.2024.12.045","DOIUrl":"10.1016/j.jad.2024.12.045","url":null,"abstract":"<p><p>Demoralization represents a clinical syndrome conceptualized as maladaptive coping to a stressor associated with discouragement, feelings of hopelessness, helplessness, and a loss of meaning in life. It is a prevalent comorbidity in individuals with severe physical illnesses and affects a substantial proportion of the general population when facing global stressors like the COVID-19 pandemic. The main aim of the study was to test whether demoralization and features of depression and anxiety might reflect distinct entities within the general population, specifically in older adults, and to explore symptom interconnections, using a network psychometrics approach. The revised demoralization scale (DS-II) and the patient health questionnaire 4 (PHQ-4) were applied to a representative sample (N = 2434) from the German general population. Network structures were analyzed using exploratory graph analysis (EGA) to identify the most distinct symptom groupings and their relationships. Stability of networks and symptom groupings was tested using bootstrap procedures. EGA revealed unidimensionality within younger adulthood and a four-factor solution within older adults, reliably distinguishing PHQ-4 and DS-II items. The most central features of the network were worthlessness, pointlessness, helplessness, feeling trapped and low mood. Suicidal ideation was more closely related to DS-II worthlessness than to PHQ-4 items. The cross-sectional design and using PHQ-4 instead of more comprehensive measures of depression and anxiety were limitations. In conclusion, in general population, demoralization symptoms can be distinguished from lack of interest or pleasure and low mood. It might represent a valid psychological construct beyond clinical populations. Further investigation of diagnostic implications is encouraged.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"491-501"},"PeriodicalIF":4.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between hypothalamic-pituitary-adrenal (HPA) axis hormone levels, major depression features and antidepressant effects of ketamine.","authors":"Polymnia Georgiou, Cristan A Farmer, Gustavo C Medeiros, Peixiong Yuan, Jenessa Johnston, Bashkim Kadriu, Todd D Gould, Carlos A Zarate","doi":"10.1016/j.jad.2024.12.036","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.036","url":null,"abstract":"<p><strong>Background: </strong>Subanesthetic doses of (R,S)-ketamine (ketamine) have demonstrated rapid and robust antidepressant effects in individuals with depression. However, individual variability in response to ketamine exists, and current biomarkers of ketamine treatment response are not entirely understood. Preclinical evidence suggests a link between hypothalamic-pituitary-adrenal (HPA) axis activation, a determinant of the stress response system, and ketamine's efficacy in stressed mice exhibiting enhanced antidepressant responses. Here, we assessed the relationship between HPA axis, major depression features, and antidepressant response to ketamine in humans.</p><p><strong>Methods: </strong>We investigated 42 participants following medication washout with treatment-resistant depression who participated in a randomized, placebo-controlled, crossover trial receiving intravenous ketamine. Plasma levels of corticotropin-releasing factor (CRF), adrenocorticotropic hormone (ACTH), and cortisol were measured at baseline. Ketamine's antidepressant effects were assessed using the Montgomery-Asberg Depression Rating Scale.</p><p><strong>Results: </strong>We found that baseline HPA axis hormone levels did not significantly moderate the antidepressant effects of ketamine. However, a negative association was observed between ACTH and CRF levels and the overall duration of depressive episodes, suggesting potential biomarker implications. Also, a negative correlation between baseline depressive scores and age of onset was observed, suggesting that the severity of depression might be greater if it develops at a younger age, indicating more enduring stress on the brain and body.</p><p><strong>Discussion: </strong>Although we did not find a moderation effect of the plasma HPA axis hormones on the antidepressant effects of ketamine, moderation effects of the brain HPA axis hormones cannot be precluded and warrants further investigation. Importantly, our results implicate HPA axis components as potential biomarkers for the duration of depressive episodes.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between NIH Toolbox Emotion Battery measures and previous suicide attempt in bipolar I disorder.","authors":"Noah M Gritters, Gail I S Harmata, Deniz Buyukgok, Pooya Hazegh, Karin F Hoth, Ercole John Barsotti, Jess G Fiedorowicz, Aislinn J Williams, Jenny Gringer Richards, Leela Sathyaputri, Samantha L Schmitz, Jeffrey D Long, John A Wemmie, Vincent A Magnotta","doi":"10.1016/j.jad.2024.12.040","DOIUrl":"10.1016/j.jad.2024.12.040","url":null,"abstract":"<p><p>Suicide attempts are more prevalent in people with bipolar I disorder (BD-I) than in the general population. Most prior studies of suicide in BD-I have focused on separate emotion-related assays or clinician-administered scales, whereas a single, brief, and multidimensional battery of self-report measures has not yet been explored. Here, we utilized the NIH Toolbox Emotion Battery (NIHTB-EB) to assess various emotional measures, determine which were cross-sectionally associated with prior suicide attempt in BD-I, evaluate whether the NIHTB-EB could be used to identify past suicide attempt in BD-I with machine learning, and compare model performance versus using clinical mood scales. The study included 39 participants with BD-I and history of suicide attempt, 48 with BD-I without history of suicide attempt, and 58 controls. We found that 9 of the 17 measures were associated with past suicide attempt in BD-I. The initial random forest model indicated that the most important distinguishing variables were perceived stress, emotional support, anger-hostility, anger-physical aggression, perceived rejection, loneliness, and self-efficacy. Overall, the models utilizing NIHTB-EB measures performed better (69.0 % to 70.1 % accuracy) than the model containing clinical mood scale information without the NIHTB-EB measures (57.5 % accuracy). These findings suggest the NIHTB-EB could be a useful and easy-to-deploy tool in understanding the role of emotion-related measures in suicide in BD-I. Furthermore, these results highlight specific emotional subdomains that could be promising targets for longitudinal studies or interventions aimed at reducing suicide in BD-I.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"470-480"},"PeriodicalIF":4.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}