Journal of affective disorders最新文献

{"title":"Suicide attempt in the absence of suicide ideation: Prevalence and correlates among youth detained in the juvenile legal system","authors":"Melissa Padron ,&nbsp;Lin Liu ,&nbsp;Jeremy W. Pettit","doi":"10.1016/j.jad.2025.119927","DOIUrl":"10.1016/j.jad.2025.119927","url":null,"abstract":"<div><h3>Objective</h3><div>Suicide rates are 2–3 times higher among youth detained (YD) in the legal system than youth in the general population. Risk assessment strategies, including for YD, prioritize suicide ideation based on a sequential progression from ideation to attempt. However, intriguing data from adult samples document that some people who attempt suicide deny experiencing ideation. This study presents the first data on variables associated with the absence of ideation among YD who attempt suicide.</div></div><div><h3>Method</h3><div>Our sample included <em>N</em> = 427 youth detained in juvenile legal residential programs endorsing a lifetime suicide attempt. Youth mental health history, suicide ideation and attempt history, and adverse childhood experiences were assessed.</div></div><div><h3>Results</h3><div>171 youth (40.0 %) endorsing a lifetime suicide attempt denied a history of suicide ideation. Compared to youth reporting ideation, youth denying ideation had significantly lower rates of depression, somatic complaints, and neglect, and a significantly higher rate of anger/irritability.</div></div><div><h3>Conclusion</h3><div>Assessment strategies that prioritize suicide ideation likely fail to identify a substantial number of YD who are at risk of attempt. Anger/irritability may be a promising variable for inclusion to improve risk assessment strategies. Implications for theory advancement and prevention in YD are discussed.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119927"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence: Effects of exercise on depression and anxiety in patients with chronic pain: A systematic review and meta-analysis of randomized controlled trials","authors":"Jiping Chen","doi":"10.1016/j.jad.2025.119892","DOIUrl":"10.1016/j.jad.2025.119892","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119892"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the individual contributions of the 8 adverse childhood experiences (ACEs) domains to substance use.","authors":"Fares Qeadan, Jacob France, William A Barbeau","doi":"10.1016/j.jad.2025.119923","DOIUrl":"10.1016/j.jad.2025.119923","url":null,"abstract":"<p><strong>Background: </strong>Traditionally, adverse childhood experiences (ACEs) are grouped together into a cumulative score to predict substance use.</p><p><strong>Objective: </strong>To determine the effect of individual ACE domains (physical, emotional, sexual abuse, exposure to domestic violence, parental separation, household incarceration, household substance use and household mental illness) on later life substance use.</p><p><strong>Participants and setting: </strong>BRFSS data from 2019 to 2022 were used to construct 3 cohorts analyzing 5 different substance use outcomes.</p><p><strong>Methods: </strong>Logistic regression models were constructed to determine adjusted odd ratios (aORs) of substance used for each ACE domain. Random forest models served for sensitivity analyses.</p><p><strong>Results: </strong>Effect sizes varied across ACE domains and substances. Household substance use was the strongest predictor, with the highest aORs for smoking (aOR = 1.336, 95 % CI [1.266-1.410]), e-cigarette use (aOR = 1.451, 95 % CI [1.317-1.597]), and binge drinking (aOR = 1.256, 95 % CI [1.181-1.335]). Emotional abuse was the second most influential domain, particularly associated with marijuana use (aOR = 1.475, 95 % CI [1.349-1.613]). In contrast, exposure to domestic violence showed no significant associations with any substance use outcome. Sensitivity analyses using random forest models validated these findings, emphasizing the differential contributions of individual ACE domains to substance use behaviors.</p><p><strong>Conclusions: </strong>These findings emphasize that ACEs are not all entirely equal, and a cumulative score does not represent the individual effect each ACE has on substance use outcomes. Tailoring interventions and policies toward addressing specific ACE domains could significantly reduce substance use rates in later life.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119923"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressants and risk of inflammatory bowel disease: A drug-target Mendelian randomization study","authors":"Ji-Lin Wang ,&nbsp;Ye Hu ,&nbsp;Zhi-Jun Cao","doi":"10.1016/j.jad.2025.119919","DOIUrl":"10.1016/j.jad.2025.119919","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have found that antidepressants could reduce the risk of IBD, but the results are controversial. Therefore, a drug-target Mendelian randomization was applied to explore the casual relationship between antidepressants and IBD, aiming to identify new preventive uses for the drugs.</div></div><div><h3>Methods</h3><div>Target genes corresponding to classic SSRI drugs were obtained from the DrugBank database. eQTL Data was collected from the eQTLGen Consortium database. GWAS data for IBD were retrieved from the FinnGen dataset. The IVW-MR and SMR methods were used for the analysis. Heterogeneity was assessed using the Cochran's Q test, and sensitivity analyses was conducted to verify the reliability of the results.</div></div><div><h3>Results</h3><div>The IVW-MR analysis indicated a significant correlation between SIGMAR1 and risk of IBD, CD and UC. The OR with 95%CI for IBD was 0.925 (0.885–0.968), for CD was 0.91(0.845–0.979), for UC was 0.942(0.895–0.991). The SMR analysis indicated a significant correlation between SLC29A4 and risk of IBD, CD and UC. The OR with 95%CI was 1.524(1.265–1.784) for IBD, 1.767(1.343–2.19) for CD and 1.613(1.316–1.909) for UC. There were no significant genetic associations between serotonin concentration and IBD. The sensitivity analysis suggested no evidence of heterogeneity or pleiotropy among the reported results.</div></div><div><h3>Conclusion</h3><div>Activation of SIGMAR1 could reduce the risk of IBD, while activation of SLC29A4 could increase the risk of IBD. Further research is warranted to fully understand the potential role of SSRIs targeted genes in the development and progression of IBD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119919"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of early-life deprivation and threat on physical, psychological, and cognitive multimorbidity: Evidence from multinational prospective cohorts","authors":"Yueyue You ,&nbsp;Xiaobing Wu ,&nbsp;Ziyang Zhang ,&nbsp;Zhiguang Zhao ,&nbsp;Deliang Lv ,&nbsp;Fengzhu Xie ,&nbsp;Yali Lin ,&nbsp;Wei Xie ,&nbsp;Qinggang Shang ,&nbsp;Xiangfei Meng ,&nbsp;Yingying Su","doi":"10.1016/j.jad.2025.119877","DOIUrl":"10.1016/j.jad.2025.119877","url":null,"abstract":"<div><h3>Background</h3><div>The impact of early-life stressful events on physical-psychological-cognitive multimorbidity needs to be better understood. This study aimed to examine both the prevalence patterns of physical-psychological-cognitive multimorbidity and the associations between specific adverse childhood experiences (ACEs) and multimorbidity among middle-aged and older adults in China, Europe, the US, and the UK.</div></div><div><h3>Methods</h3><div>Data came from the China Health and Retirement Longitudinal Study (CHARLS) and its partner studies: the US Health and Retirement Study (HRS), the Survey of Health, Ageing and Retirement in Europe (SHARE), and the English Longitudinal Study on Ageing (ELSA). ACEs were assessed dimensionally and cumulatively. Physical, psychological, and cognitive conditions and their multimorbidity were measured. Multivariable logistic regressions were used to examine the associations between early-life stressful events on physical-psychological-cognitive multimorbidity.</div></div><div><h3>Results</h3><div>Deprivation was associated with physical-psychological disorders (China: RR: 1.25; 95 % CI: 1.20, 1.30; the US: RR: 1.13; 95 % CI: 1.05, 1.21; Europe: RR: 1.26; 95 % CI: 1.19, 1.33; and the UK: RR: 1.35; 95 % CI: 1.18, 1.52) and physical-psychological-cognitive disorders (China: RR: 1.25; 95 % CI: 1.20, 1.30; US: RR: 1.34; 95 % CI: 1.03, 1.65; Europe: RR: 1.14; 95 % CI: 1.05, 1.23; and the UK: RR: 1.89; 95 % CI: 1.48, 2.30). Threat was linked to physical-psychological disorders (China: RR: 1.19; 95 % CI: 1.10, 1.28; Europe: RR: 1.26; 95 % CI: 1.14, 1.38) and physical-psychological-cognitive disorders (China: RR: 1.14; 95 % CI: 1.05, 1.23; Europe: RR: 1.23; 95 % CI: 1.05, 1.41).</div></div><div><h3>Conclusion</h3><div>This study identified cross-national differences in the associations between threat, deprivation, and cumulative ACEs with later-life physical, psychological, and cognitive multimorbidity, highlighting the need for context-specific intervention strategies across countries.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119877"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive role of childhood maltreatment for long-term HPA axis regulation, chronic stress and postpartum depression","authors":"Meike K. Blecker ,&nbsp;Hannah Klusmann ,&nbsp;Sinha Engel ,&nbsp;Stephanie Haering ,&nbsp;Caroline Meyer ,&nbsp;Nadine Skoluda ,&nbsp;Urs M. Nater ,&nbsp;Christine Knaevelsrud ,&nbsp;Sarah Schumacher","doi":"10.1016/j.jad.2025.119914","DOIUrl":"10.1016/j.jad.2025.119914","url":null,"abstract":"<div><h3>Background</h3><div>Childhood maltreatment increases the risk for mental disorders, including postpartum depression (PPD). Outside the peripartum period, attenuated long-term hypothalamic-pituitary-adrenal (HPA) axis regulation and perceived chronic stress are discussed as potential mechanisms underlying the adverse effects of childhood maltreatment. Hair cortisol concentration (HCC) enables the detection of long-term changes in HPA axis regulation. This study aimed to examine the mediating role of HCC in linking childhood maltreatment with symptoms of PPD.</div></div><div><h3>Methods</h3><div>We measured childhood maltreatment, symptoms of PPD and chronic stress via online questionnaires in <em>N</em> = 111 individuals 12 months after childbirth. Current and past major depressive episodes were assessed using the Structured Clinical Interview for DSM-5. To determine HCC from months 09–12 postpartum, participants provided self-collected hair samples. Mediated regression models examined the role of HCC and chronic stress for the relation between childhood maltreatment and PPD symptoms.</div></div><div><h3>Results</h3><div>Childhood maltreatment predicted higher levels of PPD symptoms and chronic stress, and was associated with higher rates of a current depressive episode, but not with HCC. Perceived chronic stress mediated the relationship between childhood maltreatment and symptoms of PPD.</div></div><div><h3>Interpretation</h3><div>Individuals with a history of childhood maltreatment are highly vulnerable to adverse mental health outcomes in the postpartum period. Perceived chronic stress may be an important underlying pathway, while neuroendocrinological mechanisms linking CM and PPD remain poorly understood. Longitudinal studies are needed to improve our understanding of the pathways between CM and PPD, thereby enabling the development of targeted prevention and intervention strategies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119914"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns and trends of medication use among patients with bipolar disorder in Northeast China: A study from a large psychiatric center (2013-2022).","authors":"Yu Zhang, Mingyang Yao, Huanliang Li, Yuehua Wang, Shengyuan Hao, Guoliang Pan, Hefeng Xu, Xiaoyu Han, Guangyu Zhou, Liying Shao, Wei Sun, Yan Luan, Guowei Pan","doi":"10.1016/j.jad.2025.119920","DOIUrl":"10.1016/j.jad.2025.119920","url":null,"abstract":"<p><strong>Background: </strong>The medication patterns and trends among bipolar disorder patients in mainland China remain unclear. This study, as the first attempt in northeast China, is designed to clarify the medication patterns and elucidate medication trends of bipolar disorder patients from 2013 to 2022.</p><p><strong>Methods: </strong>The study included 1812 bipolar disorder patients from a large psychiatric center who received treatment from 2013 to 2022. We examined the episode types of patients and medications for treatment of bipolar disorder, including lithium, anticonvulsants, antipsychotics, antidepressants, and sedative-hypnotics. Trends of episode types, medication, and combinations were analyzed using the Cochran-Armitage Trend test. Patterns of medication use were analyzed using the association rule mining method.</p><p><strong>Results: </strong>Among the patients, manic/hypomanic episode accounted for 63.11 % to 75.39 % from 2013 to 2022. Antipsychotics had the highest usage rate (2022: 97.84 %) and showed a significant increasing trend. Lithium had the lowest usage rate (2022: 7.91 %), with no significant trend. Furthermore, combination therapy, particularly three medications, was the major treatment regimen. The proportion of patients receiving combination therapy involving three types of medications ranged from 46.07 % to 64.03 %. The most common pattern for manic/hypomanic patients was sedative-hypnotics + anticonvulsants + antipsychotics, whereas the preferred medication pattern for depressive patients was antipsychotics + antidepressants + sedative-hypnotics.</p><p><strong>Conclusions: </strong>In China, manic/hypomanic episodes remained the predominant episode type. Combination therapy, particularly with three medications, was most commonly used for treatment of bipolar disorder patients and the patterns were episode-specific. Lithium remained the least commonly prescribed medication for both episode types.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119920"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of emotional dysregulation and attachment style as indicators of obsessive compulsive symptom-severity.","authors":"Nicole Moriarty, Keith Gaynor, Elif Beyza Koş Yalvaç, Mujgan Inozu","doi":"10.1016/j.jad.2025.119909","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119909","url":null,"abstract":"<p><strong>Background: </strong>Existing research has demonstrated an association between obsessive compulsive (OCD) and emotional dysregulation. Additionally, evidence suggests a relationship between OCD and attachment style. The current study (1) investigated if a model made up of emotional dysregulation and related constructs of emotion regulation skills, attachment styles and interpersonal emotion regulation predicted obsessive compulsive symptom severity, and (2) investigated the mediating role of emotional dysregulation between attachment style and OCD in a community sample.</p><p><strong>Methods: </strong>Two hundred and twenty-six participants reported obsessive compulsive symptoms were recruited online and anonymously completed 6 questionnaires. The model was tested through hierarchical linear regressions and mediation analysis. Ethical approval was granted by University College Dublin's Ethics Committee.</p><p><strong>Results: </strong>A hierarchical linear regression employed by the current study indicated that emotional dysregulation and attachment anxiety significantly predicted OCD symptoms (F (5, 1016) = 65.7, p < 0.001). The indirect effect of emotional dysregulation as a mediator of attachment style and OCD symptom-severity was significant (B = 0.4311; 95 % CI: 0.3339 to.5381).</p><p><strong>Limitations: </strong>The current study utilized a cross-sectional design and causation cannot be derived from the results. The use of self-report scales may allow for biased responses and a predominantly Irish sample limits the generalizability of the study.</p><p><strong>Conclusion: </strong>The current study has both clinical and empirical implications as it demonstrates the role of emotional dysregulation and attachment insecurity in OCD severity, potentially advising the direction of future OCD interventions.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119909"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of the online Patient Health Questionnaire-9 and its abbreviated versions, the PHQ-8 and PHQ-2, for detecting major depressive disorder","authors":"Moritz Thake ,&nbsp;Franziska Sikorski ,&nbsp;Bernd Löwe ,&nbsp;Sebastian Kohlmann","doi":"10.1016/j.jad.2025.119926","DOIUrl":"10.1016/j.jad.2025.119926","url":null,"abstract":"<div><h3>Background</h3><div>The Patient Health Questionnaire-9 (PHQ-9) and its abbreviated versions, the PHQ-8 and the PHQ-2, are frequently used as online depression screeners. Their accuracy to detect major depressive disorder (MDD) has been examined in only a limited number of studies in student samples.</div></div><div><h3>Objective</h3><div>Assessment of the diagnostic accuracy of PHQ-9, PHQ-8 and PHQ-2 to detect MDD.</div></div><div><h3>Methods</h3><div>A general online population sample was recruited through traditional and social media campaigns, print advertisement in public areas of several German cities and via a nationwide online access survey panel. Participants, aged 18 years or above, completed the PHQ-9 online and were assessed for MDD via telephone using the Structured Clinical Interview for DSM-5 Disorders. Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values, and the area under the curve (AUC) were calculated in a cross-sectional design to assess diagnostic accuracy.</div></div><div><h3>Results</h3><div>In total, <em>n</em> = 790 participants (574 (72.7 %) female, age: 37.4 (SD = 13.9; range: 18–79)) were screened with the PHQ-9 (mean = 11.1; SD = 5.4) and interviewed via telephone using the SCID (41.2 % fulfilling the criterion of MDD). The optimal cut-off was 11 points for the PHQ-9 (sensitivity: 0.77; specificity: 0.68; AUC: 0.80; NPV: 0.81; PPV: 0.63), 11 points for the PHQ-8 (sensitivity: 0.74; specificity: 0.71; AUC: 0.79; NPV: 0.79; PPV: 0.64) and 3 points for the PHQ-2 (sensitivity: 0.68; specificity: 0.74; AUC: 0.76; NPV: 0.77; PPV: 0.65). Descriptively, age or gender had limited impact on diagnostic accuracy.</div></div><div><h3>Conclusions</h3><div>In conclusion, the online version of the PHQ-9, PHQ-8, and PHQ-2 show moderate to good diagnostic accuracy to detect MDD. Still, screening results should be interpreted with caution as a number of cases are likely to be either missed or incorrectly identified.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119926"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal thoughts and behaviors in adolescents with mood disorders: Insights from a nationally representative sample","authors":"Mikaela K. Dimick ,&nbsp;Benjamin I. Goldstein ,&nbsp;Jian-Ping He ,&nbsp;Kathleen R. Merikangas","doi":"10.1016/j.jad.2025.119882","DOIUrl":"10.1016/j.jad.2025.119882","url":null,"abstract":"<div><h3>Background</h3><div>Suicide is a leading cause of death in adolescents, and major mood disorders confer a greatly increased risk. Few population-based studies have investigated the distinct and overlapping clinical correlates of suicidality in adolescents with bipolar disorder (BD) and major depressive disorder (MDD). Understanding these correlates may inform targeted prevention and intervention strategies. This study aims to examine the clinical correlates of suicidal thoughts and behaviors (STBs) in a nationally representative sample of adolescents with and without mood disorders.</div></div><div><h3>Methods</h3><div>Data from the National Comorbidity Survey – Adolescent Supplement (NCS-A; 2001–2004) was examined to compare the prevalence and clinical correlates of suicidal ideation/plan and suicide attempts between adolescents with BD, MDD, and those without mood disorders. Participants, ages 13–18 years, were interviewed using a modified version of the Composite International Diagnostic Interview to confirm diagnoses for BD (<em>n</em> = 295), MDD (<em>n</em> = 1112) or controls without mood disorders (<em>n</em> = 8716).</div></div><div><h3>Results</h3><div>Lifetime prevalence of suicide attempts in adolescents with BD (14.9 %) and MDD (17.2 %) was higher than in controls (1.4 %). Similarly, suicidal plans/ideation were more prevalent among adolescents with BD (20.4 %) and MDD (22.8 %) than controls (6.5 %). STBs were associated with longer duration of depressive episodes, antidepressant use, mental health treatment, and experiences of physical/sexual abuse in both MDD and BD groups.</div></div><div><h3>Conclusions</h3><div>STBs are associated with multiple shared clinical correlates alongside diagnosis-specific correlates. These findings highlight the significance of depression burden and reward-related behaviors (smoking, SUD, eating disorders) as risk indicators, which could guide the development of targeted prevention and treatment strategies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119882"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}