Journal of affective disorders最新文献

{"title":"Heterogeneous trajectories of depressive symptoms in the aging process: A sequence analysis within nine-year follow-ups of Chinese cohorts.","authors":"Yaoyue Li","doi":"10.1016/j.jad.2026.122172","DOIUrl":"10.1016/j.jad.2026.122172","url":null,"abstract":"<p><strong>Objective: </strong>Depression in later life has increasingly become alarming with the progressive population aging worldwide, but the dynamics of depressive symptoms may vary across individuals in the aging process. This study aims to investigate heterogeneity in trajectories of depressive symptoms among Chinese cohorts as they age and examine demographic and socioeconomic factors associated with different trajectory patterns.</p><p><strong>Methods: </strong>Using data from the 2011-2020 China Health and Retirement Longitudinal Study (CHARLS), the study employed sequence analysis to address heterogeneity in the trajectories of depressive symptoms for Chinese cohorts aged 45-64 years (n = 6161) in 2011 and conducted multinomial logistic regression to examine factors associated with the trajectory membership.</p><p><strong>Results: </strong>43% of respondents did not report depressive symptoms over the study period. An additional eight types of trajectories of depressive symptoms were identified among respondents who experienced the emergence, persistence, or remission of depression over time. Better socioeconomic conditions were associated with decreased risks of entering depressive trajectories. Age was not necessarily linked to the presence of depression; yet, age-related events and experiences, such as the loss of spouse, diminishing family connections, and declining physical health, played significant roles in developing and sustaining depressive symptoms as people aged.</p><p><strong>Conclusions: </strong>Trajectories of depressive symptoms exhibit great heterogeneity across populations entering older ages. While long-term efforts should target socioeconomic inequalities, promoting social connections offers a modifiable pathway to mitigate depressive risk in the aging population.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122172"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial, ethnic, and nativity disparities in elevated symptoms and diagnosis of perinatal mood and anxiety disorders: A population-level study.","authors":"Slawa Rokicki, Erin-Ellen Dillon Fink, Julie Blumenfeld","doi":"10.1016/j.jad.2026.122155","DOIUrl":"10.1016/j.jad.2026.122155","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated racial, ethnic, and nativity disparities in diagnosis of perinatal mood and anxiety disorders (PMADs) for individuals with elevated symptoms in a state with universal screening of perinatal depression.</p><p><strong>Methods: </strong>This was a cross-sectional analysis of linked New Jersey birth records and hospital discharge records between January 2016 and December 2019 (n = 338,537 births). Primary outcomes were a positive screen for elevated symptoms using the Edinburgh Postnatal Depression Scale (EPDS ≥ 10) and positive EPDS with a PMAD diagnosis on the delivery hospitalization discharge record. Logistic regression was used to estimate associations between racial, ethnic, and nativity groups and outcomes. We also examined associations between screening and diagnosis outcomes at delivery and postpartum use emergency department (ED) use.</p><p><strong>Results: </strong>Compared with White US-born, births to Asian/Pacific Islander foreign-born mothers had significantly higher odds of positive EPDS (adjusted OR 1.84, 95%CI 1.73-1.96), but lower odds of positive EPDS with PMAD diagnosis (AOR 0.36 95%CI 0.29-0.45). Similar differences were found for Black US-born, Black foreign-born, Hispanic US-born, and White foreign-born births. Compared to those with a negative screen, a positive screen without a diagnosis was associated with higher odds of a psychiatric ED visit in the first year postpartum (AOR 2.23, 95%CI 1.99-2.51).</p><p><strong>Conclusion: </strong>This population-level study found that in a setting with universal screening of perinatal depression, there remain substantial racial and ethnic disparities in the pathway from screening to diagnosis. Further research is needed to understand the mechanisms behind these findings and identify policies to improve equity in perinatal mental health care.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122155"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two neuroanatomical subtypes of major depressive disorder exhibit dissociable clinical profiles and distinct molecular signatures.","authors":"Chang Wang, Can Zhang, Zidan Li, Chen Liu, Congying Zhang, Menglin Qi, Zongya Zhao, Ting Pang, Zhixian Gao, Xiangyang Zhang, Yi Yu, Shouying Wang","doi":"10.1016/j.jad.2026.122158","DOIUrl":"10.1016/j.jad.2026.122158","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) is characterized by marked neurobiological and clinical heterogeneity; however, biologically informed neuroanatomical subtypes and their molecular correlates remain insufficiently defined.</p><p><strong>Methods: </strong>We applied the Subtype and Stage Inference (SuStaIn) model to large-scale multi-center structural MRI data from the REST-meta-MDD consortium, including 1276 patients with MDD and 1104 healthy controls, and externally validated the findings in an independent SRPBS cohort (254 patients and 701 controls). Imaging transcriptomic, bioinformatic, cell-type enrichment, and clinical analyses were performed to characterize subtype-specific features.</p><p><strong>Results: </strong>Two neuroanatomical subtypes were identified, characterized by distinct SuStaIn-inferred patterns of gray matter variation: one showing a cortical-to-cerebellar pattern and the other a cerebello-subcortical-to-cortical pattern. The subtypes showed differential clinical characteristics and brain-symptom associations. The cortical-to-cerebellar subtype was associated with greater guilt and hypochondriasis, with cerebellar structure related to affective and anxiety symptoms, whereas the second subtype showed an association between inferior frontal gyrus volume and insomnia-related symptoms. Cross-modal analyses identified distinct transcriptomic correlates associated with the two subtypes. The first subtype showed spatial enrichment of synaptic and mitochondrial pathways preferentially expressed in cortical projection neurons, whereas the second subtype showed spatial enrichment of pathways related to chromatin organization, epigenetic regulation, and calcium-MAPK signaling in cerebellar granule cells.</p><p><strong>Conclusion: </strong>These findings identify two neuroanatomical subtypes of MDD with distinct clinical and molecular profiles, providing evidence for biologically informed stratification and offering a multiscale framework for understanding disease heterogeneity.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122158"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"a healthy lifestyle is associated with lower risk of depression in type 2 diabetes, irrespective of genetic susceptibility: A UK biobank cohort study\" [J. Affect. Disord. 405 (2026) 121657, doi:10.1016/j.jad.2026.121657].","authors":"Yue Zhang, Peng Zhao, Huaxing Lou, Wentao Zhang, Chenming Zhang, Jiaqiang Liao, Haibo Zhou, Hongru Sun","doi":"10.1016/j.jad.2026.122097","DOIUrl":"10.1016/j.jad.2026.122097","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122097"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of adjunctive orexin receptor antagonist therapy in major depressive disorder: A systematic review and meta-analysis of randomized controlled trials.","authors":"Samuel Izaias Dos Santos Pereira, Martin Kotochinsky, Wellgner Fernandes Oliveira Amador, Mateus Rodrigues Alessi, Pandora Eloa Oliveira Fonseca, Alice Maria Freire Fidelis, Douglas Barroso, Nima Norbu Sherpa, Andrea Gonzalez Lezana","doi":"10.1016/j.jad.2026.122139","DOIUrl":"10.1016/j.jad.2026.122139","url":null,"abstract":"<p><strong>Background: </strong>A substantial proportion of adults with major depressive disorder (MDD) exhibit an inadequate response to selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) and experience persistent insomnia. Orexin receptor antagonists (ORAs) have emerged as a potential adjunctive treatment targeting hyperarousal mechanisms; however, their efficacy and safety remain uncertain.</p><p><strong>Methods: </strong>A systematic search of PubMed (including MEDLINE), Web of Science, Cochrane CENTRAL, Scopus, Europe PMC, and CINAHL (via EBSCO), as well as ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform (ICTRP), was conducted from inception to August 2025. Randomized controlled trials (RCTs) evaluating adjunctive ORAs in adults with MDD and inadequate response to SSRIs/SNRIs were included. Outcomes included depressive severity (Montgomery-Åsberg Depression Rating Scale [MADRS], MADRS without sleep item [MADRS-WOSI], 17-item Hamilton Depression Rating Scale [HAMD17], Patient Health Questionnaire-9 [PHQ-9]), sleep disturbance (Patient-Reported Outcomes Measurement Information System-Sleep Disturbance [PROMIS-SD]), and safety (adverse events [AEs], serious adverse events [SAEs], and discontinuations).</p><p><strong>Results: </strong>ORA therapy was associated with statistically significant improvements in depressive symptoms on MADRS (MD -1.96, 95% CI -3.29 to -0.63), MADRS-WOSI (MD -1.40, 95% CI -2.70 to -0.11), and PHQ-9 (MD -1.15, 95% CI -2.13 to -0.18), while no significant effect was observed for HAMD17. An exploratory pooled analysis combining MADRS and HAM-D17 suggested a small effect favoring ORA therapy; however, this finding should be interpreted with caution (SMD -0.15, 95% CI -0.27 to -0.03). Sleep improved on PROMIS-SD (MD -3.39, 95% CI -4.78 to -2.00). Safety outcomes did not differ significantly from placebo, and no drug-related deaths were reported.</p><p><strong>Conclusions: </strong>Adjunctive ORA therapy is associated with modest improvements in depressive symptoms and sleep disturbance, with no clear signal of increased adverse events; however, the available evidence is insufficient to establish comparative tolerability in SSRI/SNRI partial responders. These findings should be interpreted with caution given the limited number of studies. Larger, longer-duration, and more diverse RCTs are needed to define clinical relevance and long-term safety.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122139"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Investigating the shared factor structure of the GAD-7 and PHQ-9 in non-clinical samples of young adults\" [J. Affect. Disord. (2026) 121456].","authors":"William Gilbert, Marie-Josée Tremblay, Julien S Bureau, Frédéric Guay","doi":"10.1016/j.jad.2026.122095","DOIUrl":"10.1016/j.jad.2026.122095","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122095"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal associations of suicidal ideation within perinatal depressive symptom networks: A cross-lagged network analysis of over 90,000 Chinese women.","authors":"Dadong Wu, Youjing Kong, Rufang Zhou, Yaqin Gao, Jingjing Liu, Qianzhi Lin, Jiayi Zhang, Shuyan Jin, Yu Chen","doi":"10.1016/j.jad.2026.122161","DOIUrl":"10.1016/j.jad.2026.122161","url":null,"abstract":"<p><strong>Background: </strong>Maternal suicide is a leading cause of postpartum death. Suicidal ideation in perinatal depression is associated with significant risks to maternal, infant, and family well-being. While previous studies have explored trajectories of perinatal suicidal ideation, the dynamic relationships between symptoms remain unclear.</p><p><strong>Objective: </strong>To examine the predictive role of suicidal ideation within the perinatal depression symptom network across different stages of the perinatal period, using cross-lagged network analysis.</p><p><strong>Methods: </strong>Data were obtained from a population-based perinatal depression screening program in Shenzhen, China (June 2020-May 2022). Among 144,887 women with at least one EPDS screening record, 91,123 contributed data from at least two survey time points; after excluding 694 women who delivered before 32 gestational weeks, 90,429 were included in the final analysis. Depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS). Cross-lagged networks were estimated using the 'glmnet' and 'qgraph' packages in R, with missing data imputed via the mice package.</p><p><strong>Results: </strong>Suicidal ideation (EPDS Item 10) demonstrated the strongest predictive influence (out-expected influence) across all three cross-lagged networks. In the T3 → T4 network (late pregnancy to postpartum), suicidal ideation showed the highest out-expected influence (0.193), predicting symptoms including sadness (E8), tearfulness (E9), guilt (E3), and sleep disturbance (E7). The strongest edge across all networks was between suicidal ideation and sadness, with edge weights ranging from 0.1164 to 0.1820. Stability analyses indicated high robustness (CS-coefficients >0.75).</p><p><strong>Conclusion: </strong>Suicidal ideation plays a central and sustained predictive role in the evolution of perinatal depressive symptoms, particularly from late pregnancy to postpartum. Systematic monitoring of suicidal ideation and targeted interventions across perinatal stages are essential to mitigate the progression of depressive symptoms.</p><p><strong>Registration: </strong>Not registered.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122161"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyberbullying victimization and adolescent emotional and conduct problems: Roles of loneliness, emotion dysregulation, and self-esteem.","authors":"Yixuan Li, Monja Knoll, Ingrid Obsuth","doi":"10.1016/j.jad.2026.122151","DOIUrl":"10.1016/j.jad.2026.122151","url":null,"abstract":"<p><p>Cyberbullying victimization (CV) is a significant stressor linked to youth mental health outcomes, including both emotional and conduct problems. While previous studies have identified various mediators including affective, cognitive, and social domains, few studies have simultaneously examined them within an integrated model in a longitudinal design. This study investigates whether loneliness, emotion dysregulation, and self-esteem mediate the association between CV and later emotional and conduct problems. A total of 501 Chinese adolescents aged between 15 and 18 years old (53.3% female; M age = 16.33, SD = 0.47) participated in a two-wave longitudinal study with a 6-month interval. Structural equation modeling was used to test mediation effects, controlling for gender and age. Results revealed that CV at Time 1 (T1) was prospectively associated with higher emotional and conduct problems at Time 2 (T2). Loneliness and emotion dysregulation at T2 were significant mediators of CV and both emotional and conduct problems, whereas self-esteem at T2 was not a significant mediator for both outcomes. Subscale analyses of emotion dysregulation revealed distinct emotion-cognitive patterns across outcomes. Limited access to effective emotion-regulation strategies primarily explained the association between CV and emotional problems, whereas impulse-control difficulties most strongly accounted for the link between CV and conduct problems. Interventions should be multi-component, targeting these shared and distinct psychological factors through strategies addressing social isolation and emotion regulation skills while also incorporating outcome-specific approaches for comprehensive prevention and treatment.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122151"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and genetic association of comorbid provisional PMDD and ADHD in female patients with bipolar disorder.","authors":"Ji Hyun Baek, Min Jun Choi, Yeeun Shin, Eun Young Cho, Yujin Choi, Hyunju Lee, Woojae Myung, Tae Hyon Ha, Yong Min Ahn, Kyooseob Ha, Kyung Sue Hong","doi":"10.1016/j.jad.2026.122163","DOIUrl":"10.1016/j.jad.2026.122163","url":null,"abstract":"<p><strong>Background: </strong>Premenstrual dysphoric disorder (PMDD) is a common comorbidity in bipolar disorder (BD), and its association with severe illness course and other comorbidity in BD has been reported.</p><p><strong>Aims & objectives: </strong>This study aims to investigate clinical characteristics and polygenic risk features of the subgroup with DSM-5-based provisional PMDD in BD. Attention deficit/hyperactivity disorder (ADHD) symptoms and polygenic risk of ADHD were included in the analysis based on recent evidence suggesting the clinical and polygenic association between PMDD and ADHD in non-bipolar populations.</p><p><strong>Methods: </strong>Female patients with BD were grouped into 'with PMDD' and 'without PMDD.' Clinical characteristics, including other comorbidities, and polygenic risk score (PRS) of major psychiatric disorders were compared between the two groups.</p><p><strong>Results: </strong>Of the 423 participants, 187 (44.2%) met the DSM-5 criteria for provisional PMDD. Those with PMDD were more likely to have bipolar II disorder, had earlier illness onset, and experienced more frequent major depressive episodes. The prevalence of comorbid bulimia nervosa and ADHD symptom scores was higher in the PMDD group, compared to those without PMDD. In the analysis of genetic correlation using PRS for 5 major psychiatric disorders, the polygenic risk of ADHD was significantly associated with the severity of both PMDD symptom severity and ADHD symptoms.</p><p><strong>Discussion & conclusion: </strong>Our findings indicate a clinical and genetic association between comorbid PMDD and ADHD symptoms in BD. It is suggested that pleiotropic expression of a common genetic vulnerability might constitute a unique subgroup of BD, characterized by multiple comorbidities with underlying mood dysregulation.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122163"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal depression and paternity leave-taking in Italy: the mediating role of coparenting and parenting stress.","authors":"Bianca Filippi, Elisa Mancinelli","doi":"10.1016/j.jad.2026.122176","DOIUrl":"10.1016/j.jad.2026.122176","url":null,"abstract":"<p><p>The transition to parenthood represents a vulnerable period for maternal mental health. Although current literature recognizes the benefit of paternity leave-taking on maternal mental health during the post-partum and family well-being, empirical evidence on its impact remains limited. The present study aimed to evaluate the association of fathers' paternal leave on maternal mental health outcomes, as mediated by co-parenting and parenting stress. A sample of 346 Italian mothers (Mage = 34.25; SD = 4.45) of infants aged 0-12 months (Childs' age in days M = 144.97; SD = 103.05) completed an online survey assessing fathers' paternity leave uptake, maternal depressive symptoms, parenting stress, and coparenting quality. Results showed that women whose partners took paternity leave reported significantly lower depressive symptoms, lower parenting stress, and higher coparenting quality than those whose partners did not. However, paternity leave-taking was not directly associated with depressive symptoms after accounting for parenting stress and coparenting. Instead, significant indirect effects emerged: paternity leave-taking was associated with higher coparenting quality and lower parenting stress, which in turn were associated with fewer maternal depressive symptoms. Taken together, these findings highlight the positive role of fathers' paternal leave on maternal depressive symptoms during the postpartum period, particularly through increased co-parenting. Policies promoting fathers' leave uptake may therefore represent an important lever for strengthening family well-being during the transition to parenthood.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122176"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}