Journal of affective disorders最新文献

{"title":"Mediation analysis of anxiety and depression between alexithymia and frequency of headache attacks and impact on suicidal ideation in primary headache","authors":"Sara Guidotti ,&nbsp;Paola Torelli ,&nbsp;Giordano Ambiveri ,&nbsp;Alice Fiduccia ,&nbsp;Daniele Chirco ,&nbsp;Carlo Pruneti","doi":"10.1016/j.jad.2025.119716","DOIUrl":"10.1016/j.jad.2025.119716","url":null,"abstract":"<div><h3>Objective</h3><div>Considering the constellation of psychopathological symptoms that characterize primary headaches, the present study aimed to describe the relationship between specific psychopathological symptoms (i.e., anxiety, depression, and suicidal ideation), psychological variables (i.e., alexithymia), and their impact on headache frequency.</div></div><div><h3>Methods</h3><div>Socio-demographic data (gender, age, occupation, marital status, and educational level) and psychological variables (alexithymia, anxiety, depression, and suicidal ideation) of 70 people with headache (the experimental group was composed of 33 with migraine, 23 with tension-type headache, and 14 with mixed tension migraine) were compared to those of 62 age-matched control subjects. First, participants underwent a neurological examination to make the diagnosis and define the frequency of headache attacks in a month. Consequently, all participants completed the Toronto Alexithymia Scale-20, the Symptom Questionnaire, and the Symptom Checklist 90-Revised.</div></div><div><h3>Results</h3><div>The Headache group reported significantly higher levels of alexithymia, anxiety, depression, and suicidal ideation compared to controls. The mediation analysis, conducted within the patient group alone, proved that anxiety and depression fully mediated the relationship between alexithymia and monthly headache frequency, even controlling for gender and age. Additionally, the frequency of headache attacks predicted suicidal ideation.</div></div><div><h3>Discussions</h3><div>Our results highlight the importance of conducting a psychological evaluation in headache patients because some factors can increase the clinical manifestations of the disease.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119716"},"PeriodicalIF":4.9,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staying in unhappy marriages and mental health of children and adolescents: A large-scale cross-sectional study in China.","authors":"Juan Wang, Yuqian He, Xuemei Li, Ziqian Wei, Xiaopeng Du, Yinzhe Wang, Tingting Lei, Dan Zhu, Xinyu Zhou","doi":"10.1016/j.jad.2025.119725","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119725","url":null,"abstract":"<p><strong>Background: </strong>Some couples remain married despite being unhappy, for the sake of their children and adolescents. However, children and adolescents in families with unhappy marriages may be chronically expose to parental conflict, potentially increasing the risk of mental health problems more than divorce itself. Although plausible, this hypothesis has rarely been empirically tested using representative data.</p><p><strong>Methods: </strong>This large-scale cross-sectional study involved 96,431 parent-child dyads in Chongqing, China. Participants were divided into seven groups based on parental marital status and interparental relationships. Mental health problems, including depressive and anxiety symptoms, non-suicidal self-injury (NSSI) and suicide risk, was evaluated within dyads. Multivariate logistic regression was conducted to compare the risk of mental health problems among different groups.</p><p><strong>Results: </strong>About 34.56 % to 41.56 % of parents in unhappy relationships continue their marriage. Children and adolescents in the unhappy-relationship-not-divorced parents group had higher odds of depressive and anxiety symptoms, NSSI and suicide risk compared to their peers in other groups, including those with divorced parents across different levels of interparental relationships. These findings were consistent regardless of whether the interparental relationship was reported by children and adolescents or the parents.</p><p><strong>Conclusions: </strong>Public awareness should be raised that divorce may not be the worst option when parents are in an unhappy relationship, at least when considering the potential association with their child and adolescent mental health.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119725"},"PeriodicalIF":4.9,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance spectroscopy studies in children and adolescents with depression: A systematic review and meta-analysis.","authors":"Hong Zhou, Yao Gao, Tao Dong, Jie Wang, Zhi-Fen Liu","doi":"10.1016/j.jad.2025.119747","DOIUrl":"10.1016/j.jad.2025.119747","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies have focused on the levels of brain metabolites in patients with depression. However, there are relatively few studies on magnetic resonance spectroscopy (MRS) of adolescent depression and the related neurobiological mechanisms lack consistent conclusions. To summarize the nature of brain metabolite changes in adolescents with depression, we conducted meta-analyses of metabolite levels in proton magnetic resonance spectroscopy (¹H-MRS) studies.</p><p><strong>Methods: </strong>We searched the PubMed, Cochrane Library, Scopus, Embase, and Web of Science databases from January 1965 to December 2023. Heterogeneity across studies was evaluated using the Q and I² tests, and the random-effects model was used for analysis. Subgroup analyses were also conducted to explore potential sources of inconsistency.</p><p><strong>Results: </strong>A total of 26 studies involving 465 adolescent patients with depression and 409 healthy controls (HC) were included in this systematic review. N-acetyl aspartate (NAA) levels (SMD: -0.20, 95%CI: -0.34 to -0.05) were decreased in adolescents with depression when all brain areas were combined. In the dorsolateral prefrontal cortex white matter region, right-sided NAA (SMD: -0.76, 95 % CI: -1.36 to -0.15) and left-sided choline (Cho) levels (SMD: -0.54, 95 % CI: -0.96 to -0.12) were decreased. The levels of NAA (SMD: -0.35, 95 % CI: -0.65 to -0.05), Cho (SMD: -0.34, 95 % CI: -0.67 to -0.00) and creatine (Cr) (SMD: -0.50, 95 % CI: -0.96 to -0.03) in the anterior cingulate cortex (ACC) are reduced. The NAA/Cr levels (SMD: -1.67, 95 % CI: -3.29 to -0.05) in the left prefrontal cortex (PFC) are decreased.</p><p><strong>Conclusions: </strong>Our results suggest that the reduction in NAA levels throughout the brain regions, especially in the prefrontal cortex, among adolescent patients with depression may be due to neuronal loss. The decrease in Cr concentration indicates that using relative creatine concentration may affect the study results. The PFC and ACC may play an important role in adolescent depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119747"},"PeriodicalIF":4.9,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional relationships between cognitive decline and depression: A study of middle-aged and older adults using cross-lagged panel network analysis","authors":"Xu Ma ,&nbsp;Xingyu Zhou ,&nbsp;Yuran Qiu","doi":"10.1016/j.jad.2025.119741","DOIUrl":"10.1016/j.jad.2025.119741","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive decline and depressive symptoms are common in middle-aged and older adults. Two competing theories—Scar Theory and Vulnerability Theory—offer insights into this relationship. Scar Theory suggests depression causes cognitive impairments, while Vulnerability Theory posits cognitive deficits predispose individuals to depression. Understanding these mechanisms is crucial for developing effective interventions, especially in underrepresented regions like China.</div></div><div><h3>Methods</h3><div>We applied cross-lagged panel network (CLPN) analysis to three waves (2015, 2018, 2020) of data from the China Health and Retirement Longitudinal Study (CHARLS), comprising 14,961 participants aged ≥45 years. Cognitive functions were assessed using the MMSE subscales, and depressive symptoms using the CESD-10. Analyses were conducted separately for males and females, and network centrality metrics were used to identify key bridge symptoms.</div></div><div><h3>Results</h3><div>The results show that cognitive functions (particularly memory and orientation) predicted depressive symptoms at earlier stage, while hopelessness and low energy subsequently contributed to cognitive decline. Centrality analysis found memory and hopelessness emerged as key bridge symptoms. Sex-specific patterns were also observed: cognitive-to-depressive pathways were more prominent in females, whereas depressive-to-cognitive effects were more pronounced in males.</div></div><div><h3>Limitation</h3><div>Causal inference is limited by the observational design. COVID-19 in the 2020 wave may have introduced external confounders.</div></div><div><h3>Conclusions</h3><div>These findings provide empirical support for both the scar and vulnerability hypotheses and underscore the importance of early, symptom-specific interventions—particularly those targeting memory and hopelessness—in mitigating the reciprocal risks of depression and cognitive decline in Chinese aging populations.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119741"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144469999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initiating antidepressant treatment in pregnancy: Timing, intensity, and influential maternal and familial factors","authors":"Alexis C. Carson ,&nbsp;Nhung T.H. Trinh ,&nbsp;Hedvig Nordeng ,&nbsp;Xiaoqin Liu ,&nbsp;Trine Munk-Olsen ,&nbsp;Malin Eberhard-Gran ,&nbsp;Per Magnus ,&nbsp;Angela Lupattelli","doi":"10.1016/j.jad.2025.119726","DOIUrl":"10.1016/j.jad.2025.119726","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the timing and intensity of antidepressant initiation in pregnancy using longitudinal trajectories of antidepressant prescription fills to identify associated sociodemographic, lifestyle, somatic, mental health, pregnancy, and paternal factors.</div></div><div><h3>Methods</h3><div>This population-based cohort within the Norwegian Mother, Father and Child Cohort study linked to MoBa Genetics and the Prescribed Drug Registry included 1879 women with a new episode of self-reported depression/anxiety during pregnancy. Antidepressants were measured by week and average daily dose.</div></div><div><h3>Results</h3><div>There were 87 initiators, from which we identified three prescription fill trajectories: <em>Early-pregnancy initiators with rapid discontinuation</em> (<em>n</em> = 41, 47.1 %), <em>Early-pregnancy initiators with mid-pregnancy discontinuation</em> (<em>n</em> = 30, 34.5 %), and <em>Early-mid pregnancy initiators with continuation</em> (<em>n</em> = 16, 18.4 %) and three dose trajectories: <em>Low dose with discontinuation</em> (<em>n</em> = 45, 51.7 <em>%), High dose with discontinuation</em> (<em>n</em> = 26, 29.9 %), and <em>Medium dose with continuation</em> (n = 16, 18.4 %). Thyroid disorder was associated with <em>Early initiators with rapid discontinuation</em> (adjusted relative risk ratios (aRRR): 4.15, 95 % CI: 1.56–11.03) compared to <em>Unmedicated</em>. Other psychotropics pre-pregnancy increased the likelihood of being <em>Early initiators with mid-pregnancy discontinuation</em> and <em>High dose discontinuers</em> compared to <em>Unmedicated</em>. Higher maternal genetic liability for depression was strongly associated with <em>Early initiators with mid-pregnancy discontinuation</em> (aRRR = 8.57, 95 % CI: 3.09–23.74), <em>High dose discontinuers</em> and <em>Medium dose continuers</em> across comparisons<em>.</em> Adverse reproductive history, immigration and alcohol pre-pregnancy emerged as important factors.</div></div><div><h3>Conclusions</h3><div>Approximately 5 out of 100 women with a new episode of depression/anxiety initiated an antidepressant during pregnancy, predominantly in early pregnancy, with most discontinuing early to mid-pregnancy. Identified factors can be utilized by clinicians to provide personalized treatment guidance.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119726"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covarying gray and white matter networks characterize schizophrenia and bipolar disorders on a continuum: A data fusion machine learning approach and a brain network analysis","authors":"Alessandro Grecucci ,&nbsp;Alessandro Scarano ,&nbsp;Francesco Bruno ,&nbsp;Gerardo Salvato ,&nbsp;Xiaoping Yi ,&nbsp;Massimo Stella","doi":"10.1016/j.jad.2025.119708","DOIUrl":"10.1016/j.jad.2025.119708","url":null,"abstract":"<div><div>Schizophrenia (SZ) and Bipolar disorder (BD) share genetic and cerebral abnormalities, supporting an expanded continuum hypothesis. In this paper, we aim to better characterize differences and commonalities of gray and white matter features between SZ and BD to clarify how they align or diverge on this continuum. We transposed independent vector analysis (tIVA), a data fusion technique, to the gray and white matter images of 128 individuals diagnosed with SZ, 128 with BD and 127 healthy controls (CTRL), matched for gender, age and IQ. Of the 18 tIVA networks detected, three differed between SZ and BD (tIV9,14,15), primarily involving fronto-temporal regions. These same networks plus two more (tIV3,4), differed between SZ and CTRL indicating a larger compromission, whereas only one network (tIV9) differed between BD and controls. Overall, SZ displayed the more pronounced GM-WM abnormalities in both extent and severity with BD lying in an intermediate position. Of note, one network differed among all three groups (SZ, BD, and CTRL). Random forest classification confirmed these results by indicating the tIV9 as the main predictors that separate the three groups. Moreover, to appreciate eventual differences between networks across the three groups a network analyses was performed. Individuals with SZ demonstrated a significantly different clustering coefficient and density compared to CTRL. While the comparison between individuals with BD and controls did not show marked differences. This study sheds new lights on the expanded continuum hypothesis according to which individuals with schizophrenia and bipolar disorder lay on the same continuum of neurological abnormalities.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119708"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder","authors":"Łukasz Zadka ,&nbsp;Benjamin Eggerstorfer ,&nbsp;Igor Buzalewicz ,&nbsp;Chrysoula Vraka ,&nbsp;Agnieszka Rusak ,&nbsp;Godber M. Godbersen ,&nbsp;Agnieszka Opalińska ,&nbsp;Jakob Unterholzner ,&nbsp;Agnieszka Ulatowska-Jarża ,&nbsp;Cecile Philippe ,&nbsp;Katarzyna Haczkiewicz-Leśniak ,&nbsp;Leo R. Silberbauer ,&nbsp;Matej Murgaš ,&nbsp;Lukas Nics ,&nbsp;Andreas Hahn ,&nbsp;Marcus Hacker ,&nbsp;Agnieszka Gomułkiewicz ,&nbsp;Dan Rujescu ,&nbsp;Marzenna Podhorska-Okołów ,&nbsp;Rupert Lanzenberger ,&nbsp;Gregor Gryglewski","doi":"10.1016/j.jad.2025.119740","DOIUrl":"10.1016/j.jad.2025.119740","url":null,"abstract":"<div><div>With their ability to cross the blood-brain barrier, transport and regulate the release of various signaling molecules, extracellular vesicles (EVs) constitute a novel avenue to study intercellular communication in various pathologies, including psychiatric disorders. We studied 34 major depressive disorder (MDD) patients and 57 healthy controls and characterized EVs isolated from plasma using digital holographic tomography (DHT) and nanoparticle tracking analysis (NTA). EVs detected in DHT were markedly smaller and less variable in size in MDD patients. Furthermore, a lower variance of refractive indices related to the dry mass density of EVs was observed in patients. Meanwhile, NTA revealed a trend for elevated concentration of EVs in MDD. In DHT, EV dimensions correlated with plasma mRNA expression of exosomal markers <em>CD63</em> and <em>CD9</em>, with corresponding alterations in MDD. Levels of EV concentration and <em>CD9</em> were both negatively correlated with antidepressant treatment response. Utilizing electron microscopy and immunoblots we confirmed the presence of serotonin transporters (SERT) as EV cargo. SERT levels in EVs correlated with cerebral SERT binding potential in the amygdala measured using positron emission tomography. Next to the implication of altered EV communication in mood disorders, the pronounced differences in plasma EV characteristics and exosomal markers in MDD might inform the development of assays with diagnostic or prognostic value for clinical practice.</div></div><div><h3>ClinicalTrials.gov</h3><div>Patient Stratification and Treatment Response Prediction in Neuropharmacotherapy Using Hybrid Positron Emmission Tomography/Magnetic Resconance Imaging (PET/MR); https://clinicaltrials.gov/study/NCT02711215; NCT02711215.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119740"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of delivery format on the effectiveness and acceptability of self-guided interventions for depression in older adults: A systematic review and meta-analysis.","authors":"Dara Kiu Yi Leung, Dipsy Ho Sum Wong, Frankie Ho Chun Wong, Stephanie Ming Yin Wong, Oscar Long Hung Chan, Gloria Hoi Yan Wong, Wai Chi Chan, Terry Yat Sang Lum","doi":"10.1016/j.jad.2025.119756","DOIUrl":"10.1016/j.jad.2025.119756","url":null,"abstract":"<p><p>Self-guided interventions could improve the availability of evidence-based psychotherapies for late-life depressive symptoms. However, their treatment outcomes and acceptability across delivery formats remain uncertain. This review aimed to examine the effectiveness and acceptability of self-guided intervention for older adults with depressive symptoms and the impact of different intervention features. Randomised controlled trials included older adults (mean age ≥ 60 years) with elevated depressive symptoms who received self-guided interventions for depression were eligible. Trials were extracted from an existing database and updated systematic literature searches in PubMed, PsychINFO, Embase, and Cochrane Library (last update: 20th Mar 2025). Data were synthesised with random-effects meta-analysis, subgroup analysis, and meta-regressions. Outcomes included depressive symptoms, quality of life, and dropout rates. Seven studies with 1170 participants were identified. Compared to controls, self-guided interventions had small-to-moderate effect in reducing depressive symptoms at post-treatment (g = 0.46, 95 % CI 0.20 to 0.73), but the effect was not sustained at 3-to-12-month follow-up (g = 0.15, 95 % CI -0.45 to 0.74). Effects on quality of life remains inconclusive. Acceptability was comparable between self-guided interventions and control conditions (RR = 1.52, p = .294). No differences in treatment effects and acceptability were observed across delivery formats, support levels, or initial human screening. Most studies showed a moderate-to-high risk of bias (n = 6). Self-guided interventions for depression were associated with reductions in depressive symptoms and were acceptable to older adults, regardless of delivery format and level of human support. They may be considered a brief intervention option in resource-limited setting.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119756"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The moderating role of sexual identity centrality in the association between gay community stress and social anxiety among sexual minority men","authors":"Zachary A. Soulliard ,&nbsp;Anthony J. Maiolatesi ,&nbsp;Robert B. Manning III ,&nbsp;Katie Wang ,&nbsp;John E. Pachankis","doi":"10.1016/j.jad.2025.119755","DOIUrl":"10.1016/j.jad.2025.119755","url":null,"abstract":"<div><div>Gay community stress has been linked to social anxiety among sexual minority men; however, the moderating role of identity-related processes (e.g., sexual identity centrality) has yet to be examined in this association. The present study investigated the association between gay community stress and two measures of social anxiety (i.e., self-reported social anxiety symptoms and interviewer-based diagnostic assessment of social anxiety disorder), as well as the moderating role of sexual identity centrality. Data come from the baseline assessment of a randomized controlled trial testing an LGBTQ-affirmative cognitive behavioral therapy intervention with 251 sexual minority men between the ages of 18–35. Results showed that gay community stress was significantly associated with social anxiety symptoms and social anxiety disorder diagnosis. Sexual identity centrality moderated these associations, such that the link between gay community stress and both social anxiety assessments was stronger among participants with higher levels of sexual identity centrality. These significant findings remained even after accounting for sexual orientation-based discrimination and general life stress. Future research can investigate how the interaction between gay community stress, sexual identity centrality, and social anxiety develops over time to inform interventions aimed at mitigating social distress among sexual minority men.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119755"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does intimate partner violence mediate the association between adverse childhood experiences and internalizing symptomatology in women? A mediation meta-analysis.","authors":"Julia Martini, Audrey-Ann Deneault, Jenney Zhu, Nicole Racine, Pasco Fearon, Sheri Madigan, Jennifer Jenkins","doi":"10.1016/j.jad.2025.119742","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119742","url":null,"abstract":"<p><p>Research is needed to elucidate the underlying mechanisms that link adverse childhood experiences (ACEs) and internalizing symptomatology in women. In the present study, we conducted a systematic review to assess whether intimate partner violence (IPV) mediated the association between ACEs and internalizing symptomatology in women. We utilized a novel statistical technique-meta-analytic structural equation modelling (MASEM)-to examine the path model by amalgamating effect sizes across all studies, thereby combining both meta-analytic and structural equation modelling approaches. A total of 25 studies (N = 30,737 women) were included in the MASEM. The average age of female participants was 30.7 years. Results indicated that IPV partially mediated the association between ACEs and internalizing symptomatology, explaining 16 % of the total effect. Tested moderators included sociodemographic factors (age, SES, single status, and minority status) and methodological factors, including IPV characteristics (IPV category and IPV timeline), psychopathology assessment method, and the number of ACEs items measured. None of the tested moderators significantly influenced the indirect pathway. Findings suggest that IPV is an important risk factor in explaining why ACEs are associated with internalizing symptomatology in women.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119742"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}