Impact of early-life deprivation and threat on physical, psychological, and cognitive multimorbidity: Evidence from multinational prospective cohorts

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-07-14 DOI:10.1016/j.jad.2025.119877

Yueyue You , Xiaobing Wu , Ziyang Zhang , Zhiguang Zhao , Deliang Lv , Fengzhu Xie , Yali Lin , Wei Xie , Qinggang Shang , Xiangfei Meng , Yingying Su

{"title":"Impact of early-life deprivation and threat on physical, psychological, and cognitive multimorbidity: Evidence from multinational prospective cohorts","authors":"Yueyue You , Xiaobing Wu , Ziyang Zhang , Zhiguang Zhao , Deliang Lv , Fengzhu Xie , Yali Lin , Wei Xie , Qinggang Shang , Xiangfei Meng , Yingying Su","doi":"10.1016/j.jad.2025.119877","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The impact of early-life stressful events on physical-psychological-cognitive multimorbidity needs to be better understood. This study aimed to examine both the prevalence patterns of physical-psychological-cognitive multimorbidity and the associations between specific adverse childhood experiences (ACEs) and multimorbidity among middle-aged and older adults in China, Europe, the US, and the UK.</div></div><div><h3>Methods</h3><div>Data came from the China Health and Retirement Longitudinal Study (CHARLS) and its partner studies: the US Health and Retirement Study (HRS), the Survey of Health, Ageing and Retirement in Europe (SHARE), and the English Longitudinal Study on Ageing (ELSA). ACEs were assessed dimensionally and cumulatively. Physical, psychological, and cognitive conditions and their multimorbidity were measured. Multivariable logistic regressions were used to examine the associations between early-life stressful events on physical-psychological-cognitive multimorbidity.</div></div><div><h3>Results</h3><div>Deprivation was associated with physical-psychological disorders (China: RR: 1.25; 95 % CI: 1.20, 1.30; the US: RR: 1.13; 95 % CI: 1.05, 1.21; Europe: RR: 1.26; 95 % CI: 1.19, 1.33; and the UK: RR: 1.35; 95 % CI: 1.18, 1.52) and physical-psychological-cognitive disorders (China: RR: 1.25; 95 % CI: 1.20, 1.30; US: RR: 1.34; 95 % CI: 1.03, 1.65; Europe: RR: 1.14; 95 % CI: 1.05, 1.23; and the UK: RR: 1.89; 95 % CI: 1.48, 2.30). Threat was linked to physical-psychological disorders (China: RR: 1.19; 95 % CI: 1.10, 1.28; Europe: RR: 1.26; 95 % CI: 1.14, 1.38) and physical-psychological-cognitive disorders (China: RR: 1.14; 95 % CI: 1.05, 1.23; Europe: RR: 1.23; 95 % CI: 1.05, 1.41).</div></div><div><h3>Conclusion</h3><div>This study identified cross-national differences in the associations between threat, deprivation, and cumulative ACEs with later-life physical, psychological, and cognitive multimorbidity, highlighting the need for context-specific intervention strategies across countries.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119877"},"PeriodicalIF":4.9000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165032725013199","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

The impact of early-life stressful events on physical-psychological-cognitive multimorbidity needs to be better understood. This study aimed to examine both the prevalence patterns of physical-psychological-cognitive multimorbidity and the associations between specific adverse childhood experiences (ACEs) and multimorbidity among middle-aged and older adults in China, Europe, the US, and the UK.

Methods

Data came from the China Health and Retirement Longitudinal Study (CHARLS) and its partner studies: the US Health and Retirement Study (HRS), the Survey of Health, Ageing and Retirement in Europe (SHARE), and the English Longitudinal Study on Ageing (ELSA). ACEs were assessed dimensionally and cumulatively. Physical, psychological, and cognitive conditions and their multimorbidity were measured. Multivariable logistic regressions were used to examine the associations between early-life stressful events on physical-psychological-cognitive multimorbidity.

Results

Deprivation was associated with physical-psychological disorders (China: RR: 1.25; 95 % CI: 1.20, 1.30; the US: RR: 1.13; 95 % CI: 1.05, 1.21; Europe: RR: 1.26; 95 % CI: 1.19, 1.33; and the UK: RR: 1.35; 95 % CI: 1.18, 1.52) and physical-psychological-cognitive disorders (China: RR: 1.25; 95 % CI: 1.20, 1.30; US: RR: 1.34; 95 % CI: 1.03, 1.65; Europe: RR: 1.14; 95 % CI: 1.05, 1.23; and the UK: RR: 1.89; 95 % CI: 1.48, 2.30). Threat was linked to physical-psychological disorders (China: RR: 1.19; 95 % CI: 1.10, 1.28; Europe: RR: 1.26; 95 % CI: 1.14, 1.38) and physical-psychological-cognitive disorders (China: RR: 1.14; 95 % CI: 1.05, 1.23; Europe: RR: 1.23; 95 % CI: 1.05, 1.41).

Conclusion

This study identified cross-national differences in the associations between threat, deprivation, and cumulative ACEs with later-life physical, psychological, and cognitive multimorbidity, highlighting the need for context-specific intervention strategies across countries.

查看原文本刊更多论文

早期生活剥夺和威胁对身体、心理和认知多重疾病的影响：来自多国前瞻性队列的证据。

背景：早期生活压力事件对身体-心理-认知多重疾病的影响需要更好地理解。本研究旨在研究中国、欧洲、美国和英国中老年人群中身体、心理和认知多重发病的流行模式，以及特定童年不良经历（ace）与多重发病之间的关系。方法：数据来自中国健康与退休纵向研究（CHARLS）及其合作研究：美国健康与退休研究（HRS）、欧洲健康、老龄化与退休调查（SHARE）和英国老龄化纵向研究（ELSA）。对ace进行维度（威胁、剥夺）和累积性评估。测量了身体、心理和认知状况及其多病性。多变量逻辑回归检验了相关性。结果：剥夺与身心障碍相关(中国：RR: 1.25；95 % ci: 1.20, 1.30；美国：RR: 1.13；95 % ci: 1.05, 1.21；欧洲：RR: 1.26；95 % ci: 1.19, 1.33；英国：RR: 1.35；95 % CI: 1.18, 1.52)和生理-心理-认知障碍(中国：RR: 1.25；95 % ci: 1.20, 1.30；Us: rr: 1.34；95 % ci: 1.03, 1.65；欧洲：RR: 1.21；95 % ci: 1.05, 1.23；英国：RR: 1.89；95 % ci: 1.48, 2.30)。威胁与身心障碍相关(中国：RR: 1.19；95 % ci: 1.10, 1.28；欧洲：RR: 1.26；95 % CI: 1.14, 1.38)和生理-心理-认知障碍(中国：RR: 1.14；95 % ci: 1.05, 1.23；欧洲：RR: 1.23；95 % ci: 1.05, 1.41)。结论：本研究确定了威胁、剥夺和累积性不良经历与晚年身体、心理和认知多重发病率之间的关联存在跨国差异，强调了各国需要针对具体情况采取干预策略的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.