Journal of affective disorders最新文献

{"title":"Emotion regulation profiles and symptoms of depression and anxiety","authors":"Ariana G. Reichler ,&nbsp;David A. Preece ,&nbsp;James J. Gross","doi":"10.1016/j.jad.2025.119548","DOIUrl":"10.1016/j.jad.2025.119548","url":null,"abstract":"<div><div>Symptoms of depression and anxiety are pervasive and highly comorbid, prompting efforts to identify underlying transdiagnostic processes. Emotion regulation (ER) may be one such process; however, most research to date has focused on a limited set of ER strategies. Our aim in this study was to comprehensively examine the ER profiles characterizing a range of depression and anxiety symptoms. Our sample (<em>N</em> = 444) completed a battery of psychometric questionnaires. We assessed ER strategy use across all five stages of the <em>process model of emotion regulation</em>, along with symptoms of depression, stress, panic-related anxiety, generalized anxiety/worry, social anxiety, and health anxiety. Regression analyses showed that ER patterns explained significant variance (8.9 % to 33.1 %) in each symptom category. Among the strongest unique predictors were avoiding unpleasant situations and expressive suppression, both associated with greater symptoms, and cognitive reappraisal (considering benefits), which predicted lesser symptoms. A latent profile analysis identified seven profiles based on symptom patterns and ER use. Three profiles exhibited elevated symptoms but varied widely in ER use. The most symptomatic profile predominantly relied on disengagement-oriented strategies, while other elevated profiles displayed either uniformly high or low ER strategy use. Our findings highlight the transdiagnostic relevance of a wide range of ER strategies, revealing distinct ER patterns even among individuals with similar symptom presentations. They aid conceptual understanding of the link between ER and depression and anxiety symptoms and offer promising assessment and treatment targets.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119548"},"PeriodicalIF":4.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subsequent suicide acts of 1830 suicidal crisis hotline callers: A one-month follow-up study","authors":"Yi Gong ,&nbsp;Lihua Lin ,&nbsp;Jiali Wang ,&nbsp;Xijia Tang ,&nbsp;Liang Zhou","doi":"10.1016/j.jad.2025.119489","DOIUrl":"10.1016/j.jad.2025.119489","url":null,"abstract":"<div><h3>Objectives</h3><div>Suicide is a concerning public health issue. This study aimed to explore the person-time incidence rate of suicide acts and to identify the risk factors of suicidal acts during the one-month follow-up period among suicidal hotline callers.</div></div><div><h3>Methods</h3><div>A prospective longitudinal study was conducted in Guangzhou Psychological Aid Hotline between Feb 2020 and June 2021. Information about subsequent suicide acts was collected during four telephone follow-ups in one month after the index call. The person-time incidence rate of subsequent suicide acts was calculated. Multivariate logistic regression and Anderson-Gill regression were used to evaluate the risk factors of subsequent suicidal acts.</div></div><div><h3>Results</h3><div>A total of 1830 suicidal callers were included. During the follow-ups, 200 callers had made at least one suicide attempt (35 callers attempted more than once) and 5 callers died by suicide. Approximately 60 % of suicide attempts happened during the first week after the index call. <em>The person-time incidence rate</em> was 16.0/100 person-month. Younger age (<em>OR</em> = 0.94, <em>HR</em> = 0.91), history of mental disorders (<em>OR</em> = 1.93, <em>HR</em> = 1.88), history of suicide attempt (<em>OR</em> = 1.58, <em>HR</em> = 1.99), suicide plan or suicide attempt at baseline (vs. suicide ideation, <em>OR</em> = 1.83, <em>HR</em> = 2.44; <em>OR</em> = 1.95, <em>HR</em> = 2.31, respectively) were predictors of subsequent suicide act (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Hotline callers were a high-risk population for suicide even after intervention. The highest suicide risk of the callers was in the first week after the call, followed by a gradual decline. More robust and intense interventions should be taken to reduce suicide risks in suicidal callers.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119489"},"PeriodicalIF":4.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the efficacy of levetiracetam as an adjunct to olanzapine for acute manic episodes of bipolar disorder: A double-blind placebo-controlled randomized clinical trial","authors":"Hasan Mirzazadeh ,&nbsp;Maryam Nourollahi ,&nbsp;Kasra Assadian ,&nbsp;Sanaz Bordbar ,&nbsp;Leila Razeghian Jahromi ,&nbsp;Reza Moshfeghinia","doi":"10.1016/j.jad.2025.119526","DOIUrl":"10.1016/j.jad.2025.119526","url":null,"abstract":"<div><h3>Background</h3><div>Bipolar disorder (BD) involves severe mood swings, particularly manic episodes. While antipsychotics like olanzapine are common treatments, adjunct therapies are necessary to improve effectiveness and reduce side effects. This study investigates the safety and efficacy of levetiracetam, an anticonvulsant, as an adjunct treatment for acute mania in BD patients.</div></div><div><h3>Methods</h3><div>This double-blind, placebo-controlled study involved 65 patients diagnosed with bipolar I disorder (BD-I) who were experiencing acute mania. Participants were randomly assigned to receive either levetiracetam combined with olanzapine (<em>n</em> = 32) or a placebo with olanzapine (<em>n</em> = 33) over a period of 16 weeks. The primary outcomes measured included variations in Young Mania Rating Scale (YMRS) scores, Beck Scale for Suicidal Ideation (BSSI) scores, and the occurrence of adverse events. The data analysis was conducted using SPSS-23.</div></div><div><h3>Results</h3><div>There were no differences in the baseline characteristics between the case and control groups. The levetiracetam group showed a significantly greater reduction in YMRS scores compared to the placebo group, with mean scores of 2.03 (3.38) versus 16.63 (8.95) at week 16 (<em>P</em> &lt; 0.001). Improvements were noted in subcategories such as mood elevation, motor activity, and sleep disturbances (P &lt; 0.001). BSSI scores decreased in both groups (P &lt; 0.001), but there was no significant difference between the groups (<em>P</em> = 0.07). Adverse events were minimal; however, lethargy occurred more frequently in the levetiracetam group (23.3 % compared to 3.3 %, <em>P</em> = 0.05).</div></div><div><h3>Conclusions</h3><div>Levetiracetam combined with olanzapine may benefit BD patients unresponsive to olanzapine alone. Further research is required to evaluate long-term effects and confirm these findings.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119526"},"PeriodicalIF":4.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of death wishes and the impact of considering life completed in geriatric-psychiatric outpatients","authors":"Lia A. Verlinde ,&nbsp;Rob H.S. van den Brink ,&nbsp;Radboud M. Marijnissen ,&nbsp;Richard C. Oude Voshaar","doi":"10.1016/j.jad.2025.119527","DOIUrl":"10.1016/j.jad.2025.119527","url":null,"abstract":"<div><h3>Background</h3><div>Death wishes are common in later life and multifactorial. This study aims to examine prevalence and correlates of death wishes in older people referred to specialized mental health care.</div></div><div><h3>Method</h3><div>A cross-sectional study, 1784 patients aged ≥60 years referred to specialized mental health care for a functional psychiatric disorder. Participants answered questions related to death wishes, were assessed with the Mini International Neuropsychiatric Interview, the Montreal Cognitive Assessment test, and psychiatric symptom severity scales. Death wish was assessed by a single question about wanting to continue living. Determinants of death wishes were studied by hierarchical logistic regression analysis with entrance of 1) suicidality, 2) psychopathology, 3) considering life completed as potential determinants, controlling for age and sex.</div></div><div><h3>Results</h3><div>A total of 302/1784 (16.9 %) participants had a death wish; either ambivalent (<em>n</em> = 218, 12.2 %) or decisive (<em>n</em> = 84, 4.7 %). In order of decreasing predictive value, suicide risk, feeling life completed, depressive symptom severity, and having a depressive disorder distinguished patients with any thoughts of wanting to die from those who want to live (with unique generalized R² changes of 0.098, 0.071, 0.017, and 0.003, respectively). Only considering life completed differentiated between a decisive wish to die or being ambivalent towards life (unique generalized R² changes of 0.170).</div></div><div><h3>Conclusion</h3><div>Death wishes are highly prevalent among older patients with psychiatric disorders. Considering one's life completed contributes independently to death wishes in this population, beyond suicidality and severity of psychopathology. These findings argue for in-depth exploration of death wishes beyond psychopathology.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119527"},"PeriodicalIF":4.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a mobile health with tailored personalized exercise rehabilitation program for ADHD children: randomized controlled trial","authors":"Feilong Zhu ,&nbsp;Dongqing Kuang ,&nbsp;Xiaotong Zhu ,&nbsp;Baohua Xu ,&nbsp;Shengqi Lin ,&nbsp;Junlin Chen ,&nbsp;Xiaoyu Bi ,&nbsp;Zhufeng Li ,&nbsp;Li Yang ,&nbsp;Yufeng Wang ,&nbsp;Guochao Zhao ,&nbsp;Yiming Yang ,&nbsp;Yuanchun Ren","doi":"10.1016/j.jad.2025.119495","DOIUrl":"10.1016/j.jad.2025.119495","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Interventions delivered via mobile health (mHealth) could increase access to guided exercise interventions. We aimed to investigate effectiveness of a self-developed mHealth app-supported tailored exercise rehabilitation program on core symptoms (i.e., inattention and hyperactivity/impulsivity) and executive functions (EFs, specifically inhibitory control, working memory, and cognitive flexibility) in children with attention-deficit/hyperactivity disorder (ADHD).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Children with ADHD aged 6–12 (&lt;em&gt;n&lt;/em&gt; = 144) were randomly assigned to one of three groups and were offered interventions 3 times a week over a period of 12 weeks, and each session lasted 45–60 min. Experimental group 1 (EG1, &lt;em&gt;n&lt;/em&gt; = 53) received exercise interventions through videos from an exercise library that were recommended based on each participant's assessment results via mHealth used by both children and their parents. Experimental group 2 (EG2, &lt;em&gt;n&lt;/em&gt; = 45) received integrated merging of physically and cognitively demanding exercise interventions implemented offline by coaches, and control group (CG, &lt;em&gt;n&lt;/em&gt; = 46) received minimal intervention with physical activity education. Outcomes were parent-rated symptoms of inattention and hyperactivity/impulsivity, which were assessed using the Swanson, Nolan, and Pelham-version IV rating scale, and three EFs via the Stroop Color and Word Test for inhibitory control, the Rey-Osterrieth Complex Figure Test for working memory, and the Trail Making Test for cognitive flexibility. A linear mixed effects model was used to investigate the intervention effect, and the dependent variable was changed from baseline to the endpoint. Potential confounding variables (i.e., age, sex, intelligence quotient, ADHD subtype, and medicine intake) were used as covariates.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;EG1 (β = −3.54, SE 0.96, &lt;em&gt;p&lt;/em&gt; &lt; 0.001) and EG2 (β = −3.98, SE 1.00, &lt;em&gt;p&lt;/em&gt; &lt; 0.001) significantly reduced inattention scores compared to CG, and EG1 (β = −2.88, SE 0.81, p &lt; 0.001) and EG2 (β = −3.50, SE 0.84, p &lt; 0.001) also significantly reduced hyperactivity/impulsivity scores compared with CG. EG1 (β = −8.48, SE 3.27, &lt;em&gt;p&lt;/em&gt; = 0.016) and EG2 (β = −9.41, SE 3.46, p = 0.016) significantly improved inhibitory control compared with CG. EG1 (β = 4.00, SE 1.07, &lt;em&gt;p&lt;/em&gt; &lt; 0.001) and EG2 (β = 5.72, SE 1.14, p &lt; 0.001) significantly improved delayed details of working memory compared with CG. For cognitive flexibility, significant group differences were observed in EG1 versus CG (β = −17.9, SE 8.57, &lt;em&gt;p&lt;/em&gt; &lt; 0.039), EG2 versus CG (β = −39.80, SE 9.55, &lt;em&gt;p&lt;/em&gt; &lt; 0.001), and EG1 versus EG2 (β = 21.9, SE 9.12, &lt;em&gt;p&lt;/em&gt; = 0.027).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Limitation&lt;/h3&gt;&lt;div&gt;Lack of posttraining follow-up.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;mHealth with a tailored personalized exercise rehabilitation program had favorable effects on","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119495"},"PeriodicalIF":4.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of glucagon-like peptide-1 receptor agonists and seven common mental disorders: A drug target and mediation Mendelian randomization.","authors":"Zexin Zhang, Shu Li, Xinyue Dai, Cong Li, Pengfei Sun, Jianwen Qu, Haiyue Jiang, Bo Pan","doi":"10.1016/j.jad.2025.119509","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119509","url":null,"abstract":"<p><strong>Background: </strong>Glucagon-like peptide-1 receptor agonists (GLP1RA) have been associated with psychiatric symptoms; however, the causal relationships between GLP1RA and seven common mental disorders remain unknown.</p><p><strong>Methods: </strong>Mendelian Randomization (MR) were employed to explore the causalities between GLP1RA and seven common mental disorders using genome-wide association study (GWAS) data from 3 million individuals. Type 2 diabetes, blood glucose levels, insulin levels, and appetite was used as positive control. Multiple validations were performed based on the Psychiatric Genomics Consortium (PGC), UK Biobank (UKB), and FinnGen databases. A two-step MR analysis was used to assess the mediating effects. Finally, a systematic review was conducted to validate the psychotropic side effects of GLP1RA.</p><p><strong>Results: </strong>Positive control analysis indicated that the genetically predicted levels of GLP1R expression accurately reflect the physiological effects of GLP1RA, encompassing the reduction of blood glucose, fat reduction, endocrine regulation, and appetite suppression. GLP1RA reduced the risk of Major Depression Disorder (MDD) (OR = 0.6831 (0.6412-0.7277), FDR < 0.05), Bipolar Disorder (BID) (OR = 0.8019 (0.7504-0.857), FDR < 0.05), and Autism Spectrum Disorder (ASD) (OR = 0.7115 (0.6448-0.7852), FDR < 0.05). Meta results of MR support GLP1RA being a risk factor for Anorexia Nervosa (AN). The mediating MR results showed that serum glucagon and insulin levels were involved in the causal effects between GLP1R expression levels and AN (5.58 %) and BID (6.37 %) (P < 0.05). Finally, 16 observational studies were included in systematic review, most of which supported GLP1RA as a protective factor for MDD.</p><p><strong>Conclusions: </strong>Our study suggests that GLP1RA can reduce the risk of MDD, ASD, and BID. This study has significant implications for the safe application of GLP1RAs.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119509"},"PeriodicalIF":4.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic evaluation of subcutaneous ketamine injections for treatment resistant depression: A randomised, double-blind, active-controlled trial – The KADS study","authors":"Mary Lou Chatterton ,&nbsp;Johana Kevin Perez ,&nbsp;Thao Thai ,&nbsp;Jan Faller ,&nbsp;Colleen K. Loo ,&nbsp;Nick Glozier ,&nbsp;David Barton ,&nbsp;Bernhard T. Baune ,&nbsp;Natalie T. Mills ,&nbsp;Paul B. Fitzgerald ,&nbsp;Paul Glue ,&nbsp;Shanthi Sarma ,&nbsp;Dusan Hadzi-Pavlovic ,&nbsp;Vanessa Dong ,&nbsp;Donel Martin ,&nbsp;Philip B. Mitchell ,&nbsp;Michael Berk ,&nbsp;Gregory Carter ,&nbsp;Maree Hackett ,&nbsp;Sean Hood ,&nbsp;Cathrine Mihalopoulos","doi":"10.1016/j.jad.2025.119502","DOIUrl":"10.1016/j.jad.2025.119502","url":null,"abstract":"<div><h3>Background</h3><div>Ketamine is effective for treatment resistant depression (TRD); but cost-effectiveness evidence remains limited.</div></div><div><h3>Aims</h3><div>To evaluate the cost-effectiveness of subcutaneous ketamine for TRD from health sector and societal perspectives.</div></div><div><h3>Methods</h3><div>A cost-utility analysis alongside the KADS randomised controlled trial (RCT) involved 174 participants receiving ketamine or midazolam (active control) twice weekly for 4 weeks. Healthcare resource use, transportation, carer time and lost productivity data were collected via self-reported questionnaire at baseline, end of RCT (week 4) and RCT 4-week follow-up (week 8). Quality-adjusted life years (QALYs) were calculated using AQoL-8D utility values. Initial dosing was fixed (cohort 1) and changed to response-guided dosing (cohort 2). Base-case 1 included control arm treatment costs; base-case 2 excluded these costs.</div></div><div><h3>Results</h3><div>At end of RCT, cohort 2 utility values were significantly higher for ketamine than the control treatment (0.435 vs. 0.352; <em>p</em> &lt; 0.05). Health sector incremental cost-effectiveness ratios (ICERs) in base-case 1 indicated ketamine was dominant (less costly, more effective) with probabilities of falling below $50,000/QALY of 89 % (end of RCT) and 91 % (total across 8-weeks). Societal perspective probabilities were lower (30–32 %). In base-case 2, ketamine was not cost-effective (ICERs: $251,250/QALY at end of RCT; $108,500/QALY across 8-weeks), with minimal probabilities (0–5 %) of falling below $50,000/QALY.</div></div><div><h3>Conclusions</h3><div>The initial four-week ketamine treatment phase appeared cost-effective from a health sector perspective when including control arm costs, although societal perspective results were less favourable. Excluding control treatment costs highlighted substantial uncertainty, emphasising the importance of selecting an appropriate comparator for an economic evaluation.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119502"},"PeriodicalIF":4.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High suicidality rates among LGB+ youth in Japan: Demographic and psychosocial correlates","authors":"Adam O. Hill ,&nbsp;Noriyo Kaneko ,&nbsp;Natalie Amos ,&nbsp;Adam Bourne ,&nbsp;Mayumi Imahashi ,&nbsp;Gregory Armstrong ,&nbsp;Stuart Gilmour","doi":"10.1016/j.jad.2025.119468","DOIUrl":"10.1016/j.jad.2025.119468","url":null,"abstract":"<div><h3>Purpose</h3><div>This study examines correlates of suicidal ideation and attempts in the past 12 months among lesbian, gay, bisexual, pansexual, queer, asexual and questioning (LGB+) youth in Japan, where youth suicide rates are among the highest globally.</div></div><div><h3>Methods</h3><div>Data were drawn from a 2024 national cross-sectional online survey in Japan, analysing 3380 cisgender LGB+ individuals aged 15–25 years. Multivariable logistic regressions were conducted to identify significant correlates regarding suicidal ideation and suicide attempts in the past 12 months.</div></div><div><h3>Results</h3><div>In total, 30.6 % of participants reported suicidal ideation, and 8.3 % reported suicide attempts in the past 12 months. In the multivariable regression analyses, bisexual and heterosexual-identifying participants had lower odds of experiencing suicidal ideation compared to their gay-identifying peers. Cisgender women showed higher odds of suicidal ideation than cisgender men. Living in rural or remote areas, experiencing verbal, physical or sexual harassment or being socially excluded based on sexuality or gender identity, and homelessness were all associated with increased odds of suicidal ideation. Cisgender women had higher odds of a suicide attempt compared to cisgender men. Harassment and social exclusion based on sexuality or gender identity, and recent homelessness were strongly associated with higher odds of suicide attempts.</div></div><div><h3>Conclusion</h3><div>This study underscores the need for targeted suicide prevention policies for LGB+ youth in Japan, focusing on anti-harassment measures, LGB+-affirming rural support services, and homelessness prevention. Moreover, these findings highlight the need for LGB+ youth to be explicitly identified as a priority population for suicide prevention in Japan when youth suicide is at record highs.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119468"},"PeriodicalIF":4.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocognitive correlates of emotion-based urgency in DSM-5 bipolar disorder: the moderating role of diagnosis status and positive affect in a functional near-infrared spectroscopy (fNIRS) experimental study","authors":"Wen Lin Teh ,&nbsp;Steve Yin Lam Lee ,&nbsp;Nisha Chandwani ,&nbsp;Sheri L. Johnson ,&nbsp;Mythily Subramaniam ,&nbsp;Roger Chun Man Ho","doi":"10.1016/j.jad.2025.119534","DOIUrl":"10.1016/j.jad.2025.119534","url":null,"abstract":"<div><h3>Background</h3><div>A key goal of clinical neuroscience is to uncover reliable neurobiological targets for treatment. Urgency (negative or positive urgency subdomains, or N.urg/P.urg respectively), or affect-based impulsivity, is clinically relevant in bipolar disorder (BD). However, the neurocognitive correlates of positive and negative urgency have been mixed, with few considering the moderating effects of BD diagnosis and positive emotional context.</div></div><div><h3>Methods</h3><div>We conducted a 2 (group: BD vs. gender-matched healthy controls, or HC) by 2 (condition: positive vs. neutral affect) by 2 (task difficulty; within subjects) mixed, single-blind study. We examined neurocognitive correlates of urgency using EF performance and neuroimaging data from 74 participants (60 % females, M_age = 36).</div></div><div><h3>Results</h3><div>Between-group differences (HC &gt; BD) in EF performance ranged from negligible to large (η_p²: 0 to 0.18). At the <em>p</em> &lt; .05 threshold, positive urgency was correlated with lower cognitive control and working memory efficiency (<em>r</em> ranging from 0.25 to 0.34, <em>p</em> &lt; .05). N.urg was correlated with reduced activity in the ventrolateral PFC (vlPFC) during cognitive control (<em>r</em> = −0.26 to −0.29, p &lt; .05). Multivariate Analysis of Variance (MANOVA) and subsequent simple slopes analyses revealed significant moderation by emotional context and BD diagnosis. High N.urg predicted hypoactivity in the left orbitofrontal cortex in BD only, whereas high P.urg predicted hyperactivity in the right vlPFC in positive emotion context condition only. No correlations/MANOVA findings remained significant after p-value correction.</div></div><div><h3>Conclusion</h3><div>Notwithstanding the study's limitations, the nature of the relationship between urgency and neurocognitive factors may be person- and context dependent.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119534"},"PeriodicalIF":4.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity of depressive mood and its influences on adolescents: A latent profile analysis","authors":"Xinlian Yu ,&nbsp;Guijun Zhu ,&nbsp;Yi Zhang ,&nbsp;Jing Li ,&nbsp;Lu Tang ,&nbsp;Ying Xu","doi":"10.1016/j.jad.2025.119431","DOIUrl":"10.1016/j.jad.2025.119431","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to delve into the classification of depressive mood states among adolescents and their associations with taste preferences and social jet lag.</div></div><div><h3>Methods</h3><div>A convenience sampling method was employed, involving all students from four middle schools in Meishan City, Sichuan Province, China. Adolescents' taste preferences were assessed using a self-reported questionnaire. Social jet lag and depressive mood were assessed using the Munich Sleep Chronotype Questionnaire and the Center for Epidemiologic Studies Depression Scale, respectively.</div></div><div><h3>Results</h3><div>The study analyzed 5236 adolescents, categorizing their depressive mood into four groups: Group 4: severe depressive mood (5.77 %), Group 3: mild depressive mood-low interpersonal problems (12.36 %), Group 2: mild depressive mood-high interpersonal problems (10.85 %), and Group 1: healthy (71.03 %). Gender significantly predicted the latent categories of adolescent depressive mood, with males less likely to be in Groups 3 and 4. Compared to adolescents without specific taste preferences, those preferring spicy flavors had a higher probability of being in Group 3. Adolescents preferring sweet, sour, and salty flavors were more likely to be in Groups 2, 3, and 4. Notably, adolescents preferring bitter flavors exhibited a higher likelihood of being in Groups 3 and 4. Additionally, adolescents with social jet lag &lt;2 h were less likely to be in Groups 2, 3, and 4.</div></div><div><h3>Conclusion</h3><div>The study reveals substantial intergroup heterogeneity and intragroup variability in adolescent depressive mood. Female adolescents, those with specific taste preferences, and those with larger social jet lag exhibit more severe depressive mood.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119431"},"PeriodicalIF":4.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}