Journal of affective disorders最新文献

{"title":"Comorbid impairments of emotional and cognitive functions induced by different sleep deprivation durations.","authors":"Linlin Shi, Fan Li, Mengda Shan, Siyu Sun, Guanchen Yan, Lele Dong, Hao Hu","doi":"10.1016/j.jad.2026.122183","DOIUrl":"10.1016/j.jad.2026.122183","url":null,"abstract":"<p><p>Sleep deprivation (SD) is a major risk factor for neuropsychiatric disorders and is known to induce comorbid emotional and cognitive impairments; however, the temporal dynamics and underlying mechanistic pathways remain poorly defined. Here, we established a standardized rotating rod-based SD model using male ICR mice (4-6 weeks old) to systematically investigate the effects of different SD durations. (1, 2, 3, or 7 days) on emotional and cognitive functions and the potential involvement of ferroptosis-related mechanisms. Emotional and cognitive functions were evaluated using a battery of behavioral tests. Hippocampal morphology was assessed by hematoxylin-eosin staining, while hippocampal ferrous iron content, systemic oxidative stress markers including total antioxidant capacity, glutathione, and malondialdehyde, together with ferroptosis-related protein expression were quantified. Our study demonstrated that 1-day SD induced anxiety-like behaviors and a stress-induced hyperactive state, accompanied by mild cognitive deficits. In contrast, prolonged SD (3- and 7-day SD) progressively promoted depressive-like behaviors accompanied by worsening cognitive deficits. Histological analysis revealed duration-dependent neuronal loss and structural damage in the hippocampal CA1 and CA3 regions. Biochemical analyses revealed duration-dependent alterations in hippocampal Fe²⁺ levels, with marked lipid peroxidation dysregulation emerging after 7-day SD. Western blotting analysis indicated that 7-day SD markedly disrupted hippocampal ferroptosis-related SIRT1/SLC7A11/GPX4 signaling pathways. In conclusion, SD induce duration-dependent comorbid emotional and cognitive dysfunction, accompanied by hippocampal injury and ferroptosis-related alterations. These findings provide preliminary evidence for a potential link between SD-induced neurobehavioral impairments and ferroptosis-related changes, warranting further mechanistic investigation.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122183"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148337712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal connectomic signatures of functional rigidity identify bipolar disorder at the individual level.","authors":"Xin Zhang, Yang Liu, Yuanmei Xu, Hong Liang, Guangcai Chen, Zhijun Yao, Yu Fu, Rui Yang","doi":"10.1016/j.jad.2026.122181","DOIUrl":"10.1016/j.jad.2026.122181","url":null,"abstract":"<p><strong>Background: </strong>Bipolar Disorder (BD) is characterized by severe emotional instability. While traditionally viewed through the lens of anatomical dysconnectivity, it remains unclear how the brain's anatomical scaffold abnormally constrains its functional dynamics to produce such volatile mood states.</p><p><strong>Methods: </strong>We investigated the multi-modal connectome in 41 BD patients and 40 healthy controls (N=81). A high-fidelity pipeline was employed to robustly reconstruct structural networks. We then applied Graph Signal Processing (GSP) and functional gradient analysis to resting-state fMRI data to quantify structure-function alignment and hierarchical network dynamics.</p><p><strong>Results: </strong>Network-based statistics revealed no NBS-detected macroscale structural disruptions in BD. However, GSP analysis uncovered a profound pathological shift toward \"functional rigidity\". BD patients exhibited significantly elevated structure-function alignment (hyper-coupling), indicating that functional dynamics are excessively restricted by the underlying anatomical backbone. Furthermore, a multimodal connectomic model demonstrated good performance in distinguishing BD from healthy controls at the individual level (accuracy=74.1%, AUC=0.888, sensitivity=70.7%, specificity=77.5%, permutation p=0.001). SHAP analysis localized the dominant predictors to the prefrontal-limbic emotion-regulation circuit.</p><p><strong>Conclusion: </strong>BD is characterized by profound \"functional rigidity\" rather than sheer anatomical degradation. This excessive structure-function tethering may constitute a candidate inter-episode connectomic signature with preliminary individual-level discrimination potential, offering new insights into the connectomic basis of inter-episode functional dysregulation in BD and motivating prospective validation in independent longitudinal cohorts.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122181"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of rumination in the relationship between traumatic childbirth perception, birth satisfaction, and postpartum depressive symptoms.","authors":"Menekşe Nazlı Aker, Neslihan Yılmaz Sezer, Cemile Alaca, Sümbül Dinçer, Melek Hava Köprülü, Funda Özdemir","doi":"10.1016/j.jad.2026.122101","DOIUrl":"10.1016/j.jad.2026.122101","url":null,"abstract":"<p><p>This study was conducted to examine the mediating role of ruminative thinking in the relationship between perceived traumatic birth, birth satisfaction, and postpartum depressive symptoms among mothers receiving care in the postpartum unit. This descriptive study was conducted between April and December 2024 and included 309 postpartum women. Data were collected within the first 24-48 hour postpartum using the Personal Information Form, the Visual Analog Scale for Birth Satisfaction (VAS-BS), the Traumatic Childbirth Perception Scale (TCPS), the Ruminative Response Scale (RRS), and the Edinburgh Postnatal Depression Scale (EPDS). It was found that 25.9% of the participants were at risk for postpartum depression, while 21.4% perceived their childbirth as traumatic and 11.7% as very highly traumatic. The mediation analysis showed that TCPS had a significant positive effect on RRS, whereas VAS-BS had a significant negative effect. RRS positively predicted EPDS scores. The direct effect of TCPS on EPDS was not significant; however, its positive indirect effect through RRS was significant, indicating a full mediating role of RRS. VAS-BS had both a significant negative direct effect on EPDS and a significant negative indirect effect through RRS, suggesting partial mediation. The final model explained 40.7% of the variance in EPDS scores. Postpartum care should not be limited to depression screening. Women with traumatic childbirth perceptions or low birth satisfaction should also be assessed for ruminative thinking. Nurses and other healthcare professionals play a key role in supporting women's participation in birth-related decisions and helping them process their birth experiences to promote postpartum mental health.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122101"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148198914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Machine Learning Models for detecting Suicidal ideation in Chinese in-Patients with major depressive disorder: A Single-center retrospective study\" [J. Affect. Disord. 406 (2026) 121679].","authors":"Changyan Gu, Hongxin Zheng, Yu Xie, Min Pan, Xulai Zhang, Anzhen Wang, Juan Chen, Xialong Cheng","doi":"10.1016/j.jad.2026.122096","DOIUrl":"10.1016/j.jad.2026.122096","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122096"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Depression severity as a predictor of cardiovascular-kidney-metabolic syndrome progression and mortality: Results from two nationally representative cohort studies\" [J. Affect. Disord. 388 (2025) 119606].","authors":"Yujian He, Lijuan Lan, Yuting Liu, Yanting Liang, Nan Hu, Xinzhou Zhang","doi":"10.1016/j.jad.2026.122136","DOIUrl":"10.1016/j.jad.2026.122136","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122136"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148283633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased morning cortisol after ketamine treatment for suicidal depression: Exploratory report from a randomized trial.","authors":"Tse-Hwei Choo, Hanga C Galfalvy, John G Keilp, Ainsley K Burke, J John Mann, Michael F Grunebaum","doi":"10.1016/j.jad.2026.122175","DOIUrl":"10.1016/j.jad.2026.122175","url":null,"abstract":"<p><p>Depression and its severe outcomes, suicidal ideation and behavior, are exacerbated by stress. A broad literature links dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) stress response system to depression, suicidal ideation and behavior. Our midazolam-controlled clinical trial of subanesthetic, intravenous ketamine infusion for suicidal depressed patients found rapid reduction in suicidal ideation within 24 h. Here we report on an exploratory aim of the trial to investigate relationships of treatment effect and clinical response to HPA axis function via saliva cortisol analysis. Saliva cortisol awakening response was measured at baseline/pre-infusion and 24 h after with samples obtained upon morning awakening and 30 min later. A significant increase in waking cortisol 24 h after ketamine treatment was observed (t(61) = -3.15, p = 0.0025). Baseline to post-infusion increase in waking cortisol had a small to medium, nonsignificant, correlation with decrease in SI (r = -0.25, p = 0.052). These preliminary results need to be replicated but are consistent with studies suggesting increases in cortisol, if not excessive or prolonged, may enhance stress-resilience.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122175"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13361662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148329681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential analysis of CACNA1C polymorphisms among patients with depression and bipolar disorder and exploration of sleep as a mediator.","authors":"Zhi Xu, Yang Guo, Yongqi Shao, Tian Shen, Lei Chen, Zimu Chen, Suzhen Chen, Bingwei Chen, Yonggui Yuan, Yang Cai","doi":"10.1016/j.jad.2026.122152","DOIUrl":"10.1016/j.jad.2026.122152","url":null,"abstract":"<p><strong>Background: </strong>Differentiating the depressive phase of bipolar disorder (BD) from major depressive disorder (MDD) remains a significant clinical challenge. As CACNA1C is a prominent susceptibility gene for BD across diverse populations, this study evaluated the utility of its polymorphisms, combined with clinical risk factors, in distinguishing BD from MDD, while investigating the potential mediating role of sleep quality.</p><p><strong>Methods: </strong>Subjects (188 MDD, 69 BD) were compared using Mann-Whitney U or chi-square tests. Logistic regression identified independent discriminative factors. Forty-two CACNA1C SNPs were analyzed via Haploview and UNPHASED to assess genetic distributions. Mediation analysis evaluated whether sleep quality mediates the relationship between CACNA1C variants and the BD phenotype.</p><p><strong>Results: </strong>Younger onset age, positive family history, and psychotic symptoms were independently associated with BD diagnosis. Genetically, SNP rs2239128 showed a significant association with BD (adjusted P = 0.04895). Moderate linkage disequilibrium (LD) was observed for rs215976/rs215992 (r² = 0.543, D' = 0.801), and weak LD for rs215995/rs123263 (r² = 0.157, D' = 0.433). Four haplotypes-rs215976/rs215992 CC (OR = 0.257) and rs215995/rs123263 T-G (OR = 0.112), C-T (OR = 0.029), and C-G (OR = 0.814)-were significantly associated with BD (all P < 0.05). Sleep quality showed no significant mediating effect.</p><p><strong>Conclusion: </strong>Integrated clinical risk factors and CACNA1C genetic variations are promising indicators for differentiating BD from MDD. Although sleep quality did not demonstrate a mediating role, these findings contribute preliminary insights into the distinct genetic and phenotypic architecture of these disorders, offering a foundation for future mechanistic exploration and personalized interventions.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122152"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148329742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy, acceptability, and related outcomes of pharmacological interventions for acute bipolar depression: A systematic review and dose-related network meta-analysis across different age groups.","authors":"Michele Fornaro, Chiara Di Lorenzo, Vincenzo Oliva, Michele De Prisco, Eduard Vieta","doi":"10.1016/j.jad.2026.122160","DOIUrl":"10.1016/j.jad.2026.122160","url":null,"abstract":"<p><strong>Background: </strong>Acute bipolar depression poses a significant burden and socioeconomic costs. We investigated the comparative efficacy/response/acceptability of pharmacological interventions for acute bipolar depression, considering dose effects across different age groups.</p><p><strong>Methods: </strong>We conducted a network meta-analysis (NMA), searching for randomized controlled trials (RCTs) comparing pharmacological interventions against each other/or placebo in patients with acute bipolar depression (Type-I/Type-II/other), indexed in PubMed/MEDLINE, Embase, Web-of-Science/and Scopus (database inception up to 2025.11.25). Co-primary outcomes were change in depressive symptoms/response/and acceptability. Tolerability/remission/change in anxious symptoms/and risk-of-manic/hypomanic switches were secondary outcomes. Confidence-In-Network-Meta-Analysis was likewise appraised.</p><p><strong>Results: </strong>103 RCTs, encompassing 71 distinct treatment combinations, included 20,941 participants. Sensitivity analysis including low-risk-of-bias studies only and excluding outliers for possible effect modifiers indicated that lamotrigine 50 mg/day or 200 mg/day, quetiapine extended-release 150 mg/day and 300 mg/day, and lumateperone 42 mg/day outperformed placebo for depressive symptoms, with estimates ranging from -1.53(95%C.I. = -2.13;-0.93) for lamotrigine 50 mg/day, to -0.36(95%C.I. = -0.68;-0.04) for lumateperone 42 mg/day. Several additional drugs might be efficacious, although they emerged as outliers for either mean age of participants/proportion of females/BD-II participants/psychotic features/rapid cycling/baseline severity of depression/and trial duration. No treatment outperformed placebo for response/remission/acceptability/tolerability/and manic/hypomanic switches.</p><p><strong>Conclusions: </strong>Our findings are consistent with previous NMAs and current guidelines, thereby expanding knowledge by concurrently appraising different drugs, doses, and age groups.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122160"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of anxiety, depression, and post-traumatic stress disorder diagnoses among midlife and older transfeminine and transmasculine adults in the United States: A cross-sectional analysis within the STRONG cohort.","authors":"Ethan C Cicero, Jace D Flatt, Oumaima Kaabi, Vin Tangpricha, Darios Getahun, Laura McPherson, Timothy L Lash, Michael J Silverberg, Suma Vupputuri, Molly Perkins, Lisa L Barnes, Michael Goodman","doi":"10.1016/j.jad.2026.122180","DOIUrl":"10.1016/j.jad.2026.122180","url":null,"abstract":"<p><strong>Introduction: </strong>Little is known about anxiety, depression, and post-traumatic stress disorder (PTSD) diagnoses among midlife and older transgender adults (aged 45 years and older).</p><p><strong>Methods: </strong>This analysis used electronic health record data from the Study of Transition, Outcomes, and Gender, and included transfeminine (TF;n = 3080) and transmasculine (TM;n = 1705) adults aged 45+, along with demographically matched cisgender men (CM) and cisgender women (CW). History of anxiety, depression, and PTSD diagnoses among TF and TM adults and their CM and CW referents was examined. Estimates were calculated overall and stratified by age groups (45-54, 55-64, 65-74, 75+). Analyses were repeated among subgroups (gender-affirming hormone therapy (GAHT) receipt, minoritized ethnoracial status). Adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) were estimated using Poisson regression.</p><p><strong>Results: </strong>aPRs (95% CI) comparing TF to CM were 2.16 (2.08, 2.23) for anxiety, 2.77 (2.66, 2.89) for depression, and 7.11 (6.16, 8.20) for PTSD; corresponding TF versus CW estimates were 1.38 (1.34, 1.42), 1.65 (1.59, 1.71), and 3.27 (2.89, 3.71). Among TM adults, aPRs versus CM were 2.36 (2.26, 2.46) for anxiety, 3.18 (3.02, 3.34) for depression, and 11.12 (9.49, 13.04) for PTSD; corresponding estimates versus CW were 1.49 (1.44, 1.54), 1.80 (1.73, 1.88), and 4.76 (4.20, 5.39). Elevated prevalence was observed across age strata and among those with evidence of GAHT receipt and was more pronounced among individuals from minoritized ethnoracial groups.</p><p><strong>Conclusion: </strong>Anxiety, depression, and PTSD prevalence were substantially higher among TF and TM adults than among matched cisgender referents. Mental health disparities were evident across midlife and older adulthood, underscoring the need for interventions and policies that support equitable mental health among transgender adults.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"412 ","pages":"122180"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13334716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"global prevalence of anxiety, depression and stress in women with breast cancer: A systematic review and meta-analysis\" [J. Affect. Disord. (2026) 1-21/ 121,541].","authors":"Kurvatteppa Halemani, Elsa Vitale, Latha Thimmappa, Sanjay Dhiraaj, Asha P Shetty","doi":"10.1016/j.jad.2026.122098","DOIUrl":"10.1016/j.jad.2026.122098","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122098"},"PeriodicalIF":5.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}