Journal of affective disorders最新文献

{"title":"Cognition Assessment in Virtual Reality (CAVIR): Associations with neuropsychological performance and activities of daily living in patients with mood or psychosis spectrum disorders.","authors":"Andreas E Jespersen, Anders Lumbye, Johanna Schandorff, Viktoria Damgaard, Louise B Glenthøj, Merete Nordentoft, Christina Mikkelsen, Maria Didriksen, Sisse R Ostrowski, Maj Vinberg, Eva E Wæhrens, Kamilla W Miskowiak","doi":"10.1016/j.jad.2024.10.095","DOIUrl":"10.1016/j.jad.2024.10.095","url":null,"abstract":"<p><strong>Background: </strong>More ecologically valid tools are needed to better capture daily-life cognitive impairments in patients with mood or psychosis spectrum disorders in clinical settings and cognitive treatment trials. We developed the Cognition Assessment in Virtual Reality (CAVIR) test, which assesses daily-life cognitive skills in an immersive virtual reality kitchen scenario. This study investigated the validity and sensitivity of CAVIR, including its association with activities of daily living (ADL) ability.</p><p><strong>Methods: </strong>Seventy symptomatically stable patients with mood or psychosis spectrum disorders and 70 healthy controls completed CAVIR and standard neuropsychological tests and were rated for clinical symptoms, functional capacity, and subjective cognition. In addition, patients' ADL ability was evaluated with the Assessment of Motor and Process Skills.</p><p><strong>Results: </strong>Higher global CAVIR performance correlated moderately with better global neuropsychological test scores (r_s(138) = 0.60, p < 0.001) and showed a weak to moderate association with better ADL process ability in patients (r(45) = 0.40, p < 0.01), also after adjusting for sex and age (p_s ≤ 0.03). In comparison, neuropsychological performance, interviewer- and performance-based functional capacity, and subjective cognition were not significantly associated with ADL process ability (p_s ≥ 0.09). Further, CAVIR was sensitive to cognitive impairments in patients and was able to differentiate between patients with and without the ability to undertake regular employment.</p><p><strong>Limitations: </strong>The modest sample size and concomitant medication.</p><p><strong>Conclusion: </strong>Our results indicate that CAVIR is a sensitive measure of daily-life cognitive skills in patients with mood or psychosis spectrum disorders.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"1053-1063"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital mental health interventions for the treatment of depression: A multiverse meta-analysis.","authors":"Constantin Yves Plessen, Olga Maria Panagiotopoulou, Lingyao Tong, Pim Cuijpers, Eirini Karyotaki","doi":"10.1016/j.jad.2024.10.018","DOIUrl":"10.1016/j.jad.2024.10.018","url":null,"abstract":"<p><strong>Background: </strong>The varying sizes of effects in published meta-analyses on digital interventions for depression prompt questions about their efficacy.</p><p><strong>Methods: </strong>A systematic search in Embase, PsycINFO, and PubMed identified 125 randomised controlled trials up to February 2023, comparing digital interventions for depression against inactive controls. The stability of results was evaluated with a multiverse meta-analysis, thousands of meta-analyses were conducted based on different combinations of analytical choices, like target populations, intervention characteristics, and study designs.</p><p><strong>Results: </strong>A total of 3638 meta-analyses were performed based on 125 randomised controlled trials and 263 effect sizes, with a total of 32,733 participants. The average effect size was Hedges' g = 0.43, remaining positive at both the 10th (g = 0.16) and 90th percentiles (g = 0.74). Most meta-analyses indicated a statistically significant benefit of digital interventions. Larger effects were observed in meta-analyses focusing on adults, low- and middle-income countries, guided interventions, comparing interventions with waitlist controls, and patients with major depressive or unipolar mood disorders. Smaller effects appeared when adjusting for publication bias and in assessments after 24 weeks.</p><p><strong>Limitations: </strong>While multiverse meta-analysis aims to exhaustively investigate various analytical decisions, some subjectivity remains due to the necessity of making choices that affect the methodology. Additionally, the quality of the included primary studies was low.</p><p><strong>Conclusions: </strong>The analytical decisions made during performing pairwise meta-analyses result in vibrations from small to medium effect sizes. Our study provides robust evidence for the effectiveness of digital interventions for depression while highlighting important factors associated with treatment outcomes.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"1031-1044"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of metacognitive interpersonal therapy on brain structural connectivity in borderline personality disorder: Results from the CLIMAMITHE randomized clinical trial.","authors":"Giulia Quattrini, Antonino Carcione, Mariangela Lanfredi, Giuseppe Nicolò, Laura Pedrini, Daniele Corbo, Laura R Magni, Andrea Geviti, Clarissa Ferrari, Roberto Gasparotti, Antonio Semerari, Michela Pievani, Roberta Rossi","doi":"10.1016/j.jad.2024.10.107","DOIUrl":"10.1016/j.jad.2024.10.107","url":null,"abstract":"<p><strong>Background: </strong>Recently, we showed that Metacognitive Interpersonal Therapy (MIT) is effective in improving clinical symptoms in borderline personality disorder (BPD). Here, we investigated whether the effect of MIT on clinical features is associated to microstructural changes in brain circuits supporting core BPD symptoms.</p><p><strong>Methods: </strong>Forty-seven BPD were randomized to MIT or structured clinical management, and underwent a clinical assessment and diffusion-weighted imaging before and after the intervention. Fractional anisotropy (FA), mean, radial, and axial diffusivities maps were computed using FSL toolbox. Microstructural changes were assessed (i) voxel-wise, with tract based spatial statistics (TBSS) and (ii) ROI-wise, in the triple network system (default mode, salience, and executive control networks). The effect of MIT on brain microstructure was assessed with paired tests using FSL PALM (voxel-wise), Linear Mixed-Effect Models or Generalized Linear Mixed Models (ROI-wise). Associations between microstructural and clinical changes were explored with linear regression (voxel-wise) and correlations (ROI-wise).</p><p><strong>Results: </strong>The voxel-wise analysis showed that MIT was associated with increased FA in the bilateral thalamic radiation and left associative tracts (p < .050, family-wise error rate corrected). At network system level, MIT increased FA and both interventions reduced AD in the executive control network (p = .05, uncorrected).</p><p><strong>Limitations: </strong>The DTI metrics can't clarify the nature of axonal changes.</p><p><strong>Conclusions: </strong>Our results indicate that MIT modulates brain structural connectivity in circuits related to associative and executive control functions. These microstructural changes may denote activity-dependent plasticity, possibly representing a neurobiological mechanism underlying MIT effects.</p><p><strong>Trial registration: </strong>ClinicalTrials.govNCT02370316 (https://clinicaltrials.gov/study/NCT02370316).</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"1145-1152"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A psychological model of predictive factors of distress following long COVID.","authors":"Sinead A Brown, Jessica Holland, Keith Gaynor, Jessica Bramham, Fiadhnait O'Keeffe, Susan O'Flanagan, Stefano Savinelli, Patrick Mallon, Eoin Feeney, Grace Kenny, Kathleen McCann, Christine Boyd","doi":"10.1016/j.jad.2024.12.049","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.049","url":null,"abstract":"<p><strong>Background: </strong>Long COVID, described as \"the continuation or development of new symptoms 3 months after the initial SARS-CoV-2 infection\", is estimated to affect at least 10-20 % of all cases of acute SARS-CoV-2 infection. Because of its novelty, information regarding the experience of Long COVID is still emerging.</p><p><strong>Methods: </strong>This study examines psychological distress in two long COVID populations, and their experience of fatigue, cognitive failures, experiential avoidance, rumination, and perceived injustice. Participants were recruited via a long COVID hospital clinic and online self-diagnosing samples. Participants completed a battery of scales to measure psychological distress, fatigue, cognitive dysfunction, avoidance and rumination behaviours and the experience of injustice.</p><p><strong>Results: </strong>It was found that the regression model tested accounted for a significant amount of the variance in psychological distress (R² = 0.675). Cognitive failures, avoidance, rumination, and injustice experiences significantly contributed to the experience of psychological distress and a moderated mediation accounted for the effect of fatigue on psychological distress.</p><p><strong>Limitations: </strong>The self-report measures in this study did not include objective measures of symptom severity. Cross-sectional data collected at a single time-point may not capture the dynamic nature of long COVID symptoms.</p><p><strong>Conclusions: </strong>These findings identify contributing factors to the experience of psychological distress in the long COVID population, providing direction to explore supportive interventions.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of measures of mania and depression in older people with bipolar disorder.","authors":"Sabah Hussain, Elliot Brewer, Elizabeth Tyler","doi":"10.1016/j.jad.2024.12.067","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.067","url":null,"abstract":"<p><strong>Background: </strong>Previous research on bipolar disorder (BD) primarily focused on younger adults, with limited research on older adults. This systematic review is the first to investigate how mania and depression are measured in older adults with BD.</p><p><strong>Methods: </strong>The searches were completed in April 2024 using the databases PsycINFO, CINAHL Plus, MEDLINE, and Embase. Fifteen studies with a total of 1041 participants were included. These studies used quantitative measures to assess mania and depression in participants aged 50-98 with BD I or II. The studies' risk of bias was evaluated using the appropriate critical appraisal tools.</p><p><strong>Results: </strong>The Young Mania Rating Scale (YMRS) was the most commonly used measure of mania, while the Center for Epidemiologic Studies Depression Scale (CES-D) and the Hamilton Depression Rating Scale (HAM-D) were the most commonly used measures of depression. The pooled analysis revealed that older adult scores on the YMRS were relatively similar to younger cohorts in both euthymic and manic states. Variability in scores was seen across the depression scales.</p><p><strong>Limitations: </strong>The review followed rigorous systematic processes. However, in some studies, the participant's mood state was unknown, possibly impacting their pooled scores on the measures.</p><p><strong>Conclusions: </strong>The findings from the review add to our existing knowledge regarding the presentation of mania and depression in later life. There is still a great disparity in research developed for the older BD population. Large-scale studies are warranted to inform the development of tailored measures and interventions to improve the outcomes for this population.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress reactivity moderates the association between stressful life events and depressive symptoms in adolescents: Results from a population-based study.","authors":"Vilte Baltramonaityte, Alexandre A Lussier, Andrew D A C Smith, Andrew J Simpkin, Graeme Fairchild, Erin C Dunn, Esther Walton","doi":"10.1016/j.jad.2024.12.068","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.068","url":null,"abstract":"<p><strong>Background: </strong>A large body of evidence links stressful life events with depression. However, little is understood about the role of perceived impact in this association.</p><p><strong>Methods: </strong>We performed regression analysis to investigate whether self-reported stress reactivity (derived by regressing the impact-weighted life event score on the unweighted score) moderated the association between stressful life events and depressive symptoms in adolescents from the Avon Longitudinal Study of Parents and Children cohort (n = 4791), controlling for age at outcome, sex, ethnicity, and maternal education. Depressive symptoms were assessed using the self-report Short Mood and Feelings Questionnaire (score range 0-26) at 16 years of age. Adolescents also reported on their exposure to 23 possible stressful life events since age 12 and their impact, which were used to define stress reactivity groups using a residual regression approach.</p><p><strong>Results: </strong>We identified a moderating effect of stress reactivity. Adolescents with high stress reactivity showed a stronger association between the number of stressful life events and depressive symptoms than adolescents with low (b = 0.32, 95 % CI = 0.13, 0.50, p < 0.001) or typical (b = 0.44, 95 % CI = 0.28, 0.60, p < 0.001) stress reactivity.</p><p><strong>Limitations: </strong>Limitations include the use of retrospective life event measures and limited generalisability of findings to other population-based, high-risk, or clinical samples.</p><p><strong>Conclusions: </strong>When resources are limited, interventions should prioritise individuals with high stress reactivity who have experienced multiple stressful life events, as these individuals may be at greater risk for depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the psychedelic experience in psilocybin treatment for treatment-resistant depression.","authors":"Guy M Goodwin, Scott T Aaronson, Oscar Alvarez, Robin Carhart-Harris, Jamie Chai-Rees, Megan Croal, Charles DeBattista, Boadie W Dunlop, David Feifel, David J Hellerstein, Muhammad I Husain, John R Kelly, Namik Kirlic, Rasmus W Licht, Lindsey Marwood, Thomas D Meyer, Sunil Mistry, Ania Nowakowska, Tomáš Páleníček, Dimitris Repantis, Robert A Schoevers, Hollie Simmons, Metten Somers, Emma Teoh, Joyce Tsai, Mourad Wahba, Sam Williams, Allan H Young, Matthew B Young, Sidney Zisook, Ekaterina Malievskaia","doi":"10.1016/j.jad.2024.12.061","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.061","url":null,"abstract":"<p><strong>Objective: </strong>To determine the relationships between psilocybin dose, psychedelic experiences, and therapeutic outcome in treatment-resistant depression.</p><p><strong>Methods: </strong>For treatment-resistant depression, 233 participants received a single dose of 25, 10, or 1 mg of COMP360 psilocybin (a proprietary, pharmaceutical-grade synthesized psilocybin formulation, developed by the sponsor, Compass Pathfinder Ltd.) with psychological support. The resulting psychedelic experience (Five-Dimensional Altered States of Consciousness questionnaire [5D-ASC] and Emotional Breakthrough Inventory [EBI]) were measured. These proximal variables and outcome 3 weeks post-administration (change in Montgomery-Åsberg Depression Rating Scale [MADRS]) were explored using correlation analysis.</p><p><strong>Results: </strong>The mean intensity of psychedelic effects was dose-related, but distributions of scores for different doses overlapped considerably. Depression response correlated with select aspects of the psychedelic experience overall and for individual doses. At the 25 mg dose, 5D-ASC dimensions Oceanic Boundlessness (Pearson correlation coefficient r = -0.508) and Visual Restructuralization (r = -0.516), and EBI (r = -0·637) were the variables with the strongest correlation to the Week 3 change from Baseline in MADRS score.</p><p><strong>Limitations: </strong>The existence of correlation does not establish causation and exploratory findings require further replication, preferably in larger independent samples.</p><p><strong>Conclusions: </strong>The intensity of psychedelic experience overlaps widely across doses and mitigates the risk of unblinding to dose. Correlations between psychedelic experience and outcome suggest specificity in psilocybin's mechanism of action. Quality and intensity of psychedelic experience may be a measure of pharmacodynamic effect and reveal an effective dose response phenomenon for single oral doses.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"372 ","pages":"523-532"},"PeriodicalIF":4.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health during the 2022 Russo-Ukrainian War: A scoping review and unmet needs.","authors":"Michele Fornaro, Claudio Ricci, Nicolas Zotti, Claudio Caiazza, Luca Viacava, Avihai Rubinshtain Tal, Raffaella Calati, Xenia Gonda, Georgina Szabo, Michele De Prisco, Vincenzo Oliva, Giovanna Fico, Marco Solmi, Eduard Vieta, André Ferrer Carvalho, Diego Primavera, Mauro Giovanni Carta, Andrea de Bartolomeis","doi":"10.1016/j.jad.2024.12.047","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.047","url":null,"abstract":"<p><strong>Introduction: </strong>The Russo-Ukrainian War (RUW) poses a significant mental health burden, warranting a scoping review of the evidence to shed light on the unmet needs.</p><p><strong>Methods: </strong>MEDLINE/PubMed and EMBASE databases were inquired from inception until September 1st, 2023, to address the following a-priori-formulated questions: i) \"Which psychiatric population has been assessed? How did the conflict affect the functioning of people with established mental health conditions (e.g., treatment adherence, hospitalization rates, and use of illicit substances)?\" ii) \"Did any psychiatric symptoms or disorders arise because of the RUW? If so, among which groups (e.g., civilians, combatants, refugees, caregivers) and in what geographical regions?\", iii) \"The impact of the Russo-Ukrainian war: what evidence focused on pre- and post-mental health status?\", iv) \"Did the conflict affect the rates of suicidal ideation or behaviors (e.g., attempt and death by suicide)? How did the war affect mental status, especially among vulnerable populations?\", v) \"What psychosocial or medical interventions have been adopted for internally displaced people or refugees complaining of mental health disturbances?\", vi) \"What rating tools or ad-hoc measures have been developed/adopted?\", vii) \"How did the existing evidence compare the RUW with other conflicts in different geographical regions or periods?\".</p><p><strong>Results: </strong>Twenty-seven records addressed questions 1-3 and 5-6, with the female gender facing the highest burden. Reliable records about the Russian side of the conflict are needed.</p><p><strong>Conclusion: </strong>Cohort studies across different phases of the RUW and populations are required to deliver effective clinical and public health interventions, especially to at-risk populations.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal analysis of lifetime stressors and depression: Exploring intersectionality and tailoring social support for better mental health in a community population cohort.","authors":"Xiangfei Meng, Muzi Li, Yingying Su, Jean Caron, Yu-Tao Xiang","doi":"10.1016/j.jad.2024.12.066","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.066","url":null,"abstract":"<p><strong>Aims: </strong>Health inequalities studies need to understand how individuals simultaneously defined by several socioeconomic factors differ from others when facing a series of stressors across the lifespan in the risk of major depression (MD). Theoretical efforts, as well as empirical studies, have suggested a pertinent role of social support in mental health outcomes. However, little is known about which forms of social support would alleviate the negative impact of MD vulnerability in self-rated mental health across different socioeconomic groups. We investigated 1) differential associations between lifetime stressors and MD across social groups and 2) explored diverse social support forms mediating the associations between MD vulnerability and self-rated mental health (SRMH).</p><p><strong>Methods: </strong>Data analyzed were from a large longitudinal population-based cohort. Multilevel analysis of individual heterogeneity and discriminatory accuracy was used to articulate MD vulnerability in different social groups defined by ethnicity, gender, and socioeconomic status (SES). Genetic predispositions were also included in the modeling process. These social groups were then regrouped based on their vulnerability level of MD. Mediation analyses were then applied to identify which social support forms mediate the effect of MD vulnerability on SRMH.</p><p><strong>Results: </strong>Higher levels of stressors were associated with higher risk of MD, and their associations varied by different social groups. The social groups (White men with medium SES or White women with high SES) had the lowest predicted incidence of MD, whereas White women with low SES reported the highest predicted incidence of MD. Two social support forms (guidance and opportunity for nurturance) significantly mediated the indirect paths between MD vulnerability and SRMH.</p><p><strong>Conclusions: </strong>By applying an intersectional lens, the present study provides a novel quantitative instrument for documenting the associations of stress and depression in various social identities. The findings of the study suggest more focused intervention programs and strategies for risk reduction should focus on identified characteristics and pay particular attention to the combined effect of lifetime stressors and discovered social identities.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable, self-administered transcranial photobiomodulation for major depressive disorder and sleep: A randomized, double blind, sham-controlled trial.","authors":"Ta-Wei Guu, Paolo Cassano, Wan-Jing Li, Yu-Hsiung Tseng, Wen-Yu Ho, Yi-Ting Lin, Sheng-Yu Lin, Jane Pei-Chen Chang, David Mischoulon, Kuan-Pin Su","doi":"10.1016/j.jad.2024.12.065","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.065","url":null,"abstract":"<p><strong>Background: </strong>Device-based treatments exist in psychiatry for decades, but are usually operated by clinicians and require multiple office visits. Near-infrared transcranial photobiomodulation (tPBM) is a safe neurostimulation modality with potential antidepressant and hypnotic effects. We investigated the feasibility and efficacy of adjunctive tPBM treatment, self-administered by a wearable headband.</p><p><strong>Methods: </strong>We randomized 48 outpatients with major depressive disorder (MDD) into tPBM or sham with 1:1 ratio. All participants were advised to receive the device-based intervention for at least 20 min daily at their preferred time and place for 8 weeks. The compliance and adverse events were monitored throughout the trial. The Hamilton Depression Rating Scale (HAMD), Beck's Depression Inventory (BDI) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the symptoms from baseline until week-12.</p><p><strong>Results: </strong>Participants reported this self-administered intervention well-tolerated. Treatment compliance was equally good between various group-comparisons, and the adverse effects were minimal and transient. Post-treatment, the HAMD and BDI scores of patients in both tPBM group and sham group significantly decreased compared to baseline, with no between-group difference. However, a significant PSQI score reduction was only found in tPBM group from week-2 onward compared with baseline, with significant between-group difference lasting until week-12 (F_1,46 = 6.16, p = 0.017).</p><p><strong>Limitations: </strong>This smaller sample size and short treatment and follow-up durations.</p><p><strong>Conclusions: </strong>Self-administered wearable tPBM appears to be a feasible and well-tolerated in MDD patients. The low-level dosimetry appeared insufficient to produce an antidepressant effect but effective in improving sleep quality. Further studies should investigate different dosimetry and intervention time. CLINICAL TRIALS REGISTRATION NUMBER IN CLINICALTRIAL.GOV: NCT04619121.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}