Journal of affective disorders最新文献

{"title":"Temporal characteristics of moral disgust in obsessive-compulsive disorder (OCD) from a lexical perspective: An ERPs and sLORETA study","authors":"Hong Jin ,&nbsp;Ke Wan ,&nbsp;Xuemeng Chen ,&nbsp;Wanying Zhang ,&nbsp;Ke Chen ,&nbsp;Jiping Xiao ,&nbsp;Jin Jiang ,&nbsp;Yueling Liu ,&nbsp;Qingqing Zhang ,&nbsp;Yan Tang ,&nbsp;Xiaosi Li ,&nbsp;Rongrong Sheng ,&nbsp;Chunyan Zhu","doi":"10.1016/j.jad.2025.03.093","DOIUrl":"10.1016/j.jad.2025.03.093","url":null,"abstract":"<div><h3>Background</h3><div>Although many studies have hinted at the essential role of moral disgust in obsessive-compulsive disorder (OCD), few studies focused on moral disgust have been reported. Exploring the temporal characterization of moral disgust can enhance our understanding of emotional processing.</div></div><div><h3>Methods</h3><div>This study included 58 patients with OCD and 45 healthy controls (HCs) and used an adapted lexical decision task paradigm (explicit LDT) combined with event-related potentials (ERPs) analysis and standardized low-resolution brain electromagnetic tomography analysis (sLORETA) to explore the performance of patients with OCD in processing moral disgust words.</div></div><div><h3>Results</h3><div>Compared to HCs, patients with OCD showed greater EPN amplitudes (<em>P</em> = 0.009), which are localized the occipital lobe, when confronted with moral disgust words. In the comparison between core disgust words and moral disgust words, no difference was found in the ERP time windows of interest in patients with OCD. Furthermore, no difference between LDT and explicit LDT was detected in patients with OCD.</div></div><div><h3>Limitations</h3><div>We did not include word class as a variable in the study.</div></div><div><h3>Conclusions</h3><div>Our results showed abnormalities in processing moral disgust in the early stage (EPN) of lexical processing in patients with OCD compared to HCs. And, we found no significant difference between moral disgust and core disgust at any stage of lexical processing. This suggested that, similar to core disgust, moral disgust in patients with OCD triggered automatic attention and elicited higher levels of emotional experience and arousal compared to HCs.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 535-544"},"PeriodicalIF":4.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive evidence for the impact of personality styles on depression and functioning in two bipolar disorder cohorts.","authors":"Kelly A Ryan, Anastasia K Yocum, Yuhua Zhang, Peisong Han, David F Marshall, Paul Costa, Sarah Sperry, Takakuni Suzuki, Melvin G McInnis, Sebastian Zöllner","doi":"10.1016/j.jad.2025.03.131","DOIUrl":"https://doi.org/10.1016/j.jad.2025.03.131","url":null,"abstract":"<p><p>Predictors for course of illness in bipolar disorder (BD) with replicable effect are difficult to identify. Potential predictors of outcomes for BD that could inform practice include personality traits, particularly Neuroticism. However, models typically fail to consider the joint effect of multiple personality traits. We examine whether personality trait combinations (styles) enhance our ability to prospectively predict symptoms and functioning across time in two independent longitudinal research cohorts. In a discovery sample of 489 and replication sample of 2072 individuals with BD, we assessed impact of personality styles using the NEO PI-R and NEO-FFI on depression and functioning up to 14 years. Using a model considering all ten possible personality style combinations, the number of risk-related personality styles (styles associated with poor outcomes) relative to number of protective-related personality styles (styles associated with better outcomes) showed that for every additional risk relative to protective style count, the incident rate of depression increased by 11.8-15.0 % and the incident rate for poor life functioning increased by 11.1 %. This similar pattern of increased risk styles being associated with significant increases in depression and functioning was replicated in the independent STEP-BD dataset, although with slightly lower incident rate (5 % and 2.9 %). Cross validation of performance from both cohorts showed similar predictive patterns (5-11.2 % increases). The ability to predict future depression and poor functioning from the combined effects of personality traits can be clinically useful for identifying individuals at risk for poorer outcomes. Personality styles should be evaluated when planning long-term care and developing interventions.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the two-way associations between mental disorders and menstrual irregularities: A Mendelian randomization study from both directions","authors":"Fei Dong ,&nbsp;Di Yang ,&nbsp;Na Dong ,&nbsp;Jiangxia Gao","doi":"10.1016/j.jad.2025.03.128","DOIUrl":"10.1016/j.jad.2025.03.128","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to assess the bidirectional relationship between mental disorders and menstrual irregularities using a two-sample Mendelian randomization (MR) approach.</div></div><div><h3>Methods</h3><div>The analyses were conducted using a two-sample MR method. Analytical tools were derived from large-scale genome-wide association studies, including those on schizophrenia (SCZ, <em>n</em> = 127,906), bipolar disorder (BIP, <em>n</em> = 353,899), major depressive disorder (MDD, <em>n</em> = 674,452), anxiety and stress-related disorder (ASRD, <em>n</em> = 1,096,458), irregular menses (<em>n</em> = 196,550), excessive menstruation (<em>n</em> = 144,388), and dysmenorrhea (<em>n</em> = 114,540). Inverse variance weighting was used for the two-sample MR analyses, while sensitivity analyses were performed using MR-Egger, weighted median, and simple median methods.</div></div><div><h3>Results</h3><div>MDD and ASRD were associated with an increased risk of irregular menses (<em>P</em> &lt; 0.05); however, no reliable outcomes were found regarding the relationship between SCZ, BIP, and the three types of menstrual irregularities (<em>P</em> &gt; 0.05). Furthermore, ASRD was also associated with an increased likelihood of excessive menstruation and dysmenorrhea (<em>P</em> &lt; 0.05). However, the relationship between MDD and excessive menstruation was not statistically significant (<em>P</em> &gt; 0.05). Dysmenorrhea was associated with an increased risk of MDD and ASRD (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study provides strong evidence supporting the associations between ASRD and the three types of menstrual irregularities, as well as between MDD and irregular menses and dysmenorrhea.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 232-241"},"PeriodicalIF":4.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of loneliness and social isolation on sarcopenia among community-dwelling older adults: The mediating role of depressive symptoms and cognitive function","authors":"Qinqin Liu ,&nbsp;Yuli Huang ,&nbsp;Yaru Jin ,&nbsp;Binlin Wang ,&nbsp;Yanyan Li ,&nbsp;Wendie Zhou ,&nbsp;Jiaqi Yu ,&nbsp;Hejing Chen ,&nbsp;Cuili Wang","doi":"10.1016/j.jad.2025.03.143","DOIUrl":"10.1016/j.jad.2025.03.143","url":null,"abstract":"<div><h3>Background</h3><div>Although the effect of social relationships on sarcopenia has been explored, the underlying pathways remains to be elucidated. This study aimed to examine whether loneliness and social isolation influenced new-onset sarcopenia through depressive symptoms and cognitive function.</div></div><div><h3>Methods</h3><div>A total of 5003 participants aged ≥60<!--> <!-->years from 2011 (Wave 1), 2013 (Wave 2) and 2015 (Wave 3) of China Health and Retirement Longitudinal Study (CHARLS) were included. Of these, 49.1 % were females, and mean age was 67.1 years at Wave 1. Generalized linear model and Cox proportional hazard regression model were carried out to test the associations among loneliness (Wave 1), social isolation (Wave 1), depressive symptoms (Wave 2), cognitive function (Wave 2), and new-onset sarcopenia (Wave 3). A four-way decomposition was applied with depressive symptoms and cognitive function as mediators to explore their mediation and interaction effects on social relationships and sarcopenia.</div></div><div><h3>Results</h3><div>Loneliness (HR = 1.309, 95%CI = 1.073–1.596) and social isolation (HR = 1.115, 95%CI = 1.013–1.228) were associated with new-onset sarcopenia. Depressive symptoms (coefficient = 0.036, 95%CI = 0.030–0.042, attributable ratio = 23.5 %) and cognitive function (coefficient = 0.015, 95%CI = 0.010–0.019, attributable ratio = 9.8 %) mediated the association between loneliness and new-onset sarcopenia, while only cognitive function (coefficient = 0.015, 95%CI = 0.013–0.018, attributable ratio = 9.8 %) mediated the association between social isolation and sarcopenia.</div></div><div><h3>Limitations</h3><div>Although various confounding factors were adjusted for, we cannot rule out the possibility of residual confounders.</div></div><div><h3>Conclusion</h3><div>The pathways through which social relationships impact sarcopenia vary by the attributes of social relationships. Healthcare providers may address the mental and cognitive health issues to prevent and manage sarcopenia among lonely and socially isolated older adults.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 308-316"},"PeriodicalIF":4.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPA-axis multilocus genetic interaction with stress life events in predicting changes in adolescent suicidal ideation","authors":"Xian Zhao ,&nbsp;Dongfang Wang ,&nbsp;Mengmeng Chang ,&nbsp;Zhen He ,&nbsp;Zihao Zeng ,&nbsp;Menghao Ren ,&nbsp;Yiqiu Hu ,&nbsp;Zhihua Li","doi":"10.1016/j.jad.2025.03.138","DOIUrl":"10.1016/j.jad.2025.03.138","url":null,"abstract":"<div><h3>Background</h3><div>Research suggests that genetic variants linked to the hypothalamic-pituitary-adrenal (HPA) axis moderate the association between stressors and change in suicidal ideation, but examining gene-environment interactions with single polymorphisms limits power. This study investigates how interactions between stressful life events and HPA-axis polygenic risk predict changes in suicidal ideation.</div></div><div><h3>Methods</h3><div>A sample of 760 adolescents (<em>M</em>_age = 14.15 ± 0.63 years; 54.6 % girls) was followed up over two years. The polygenic risk was assessed using a multilocus genetic profile score (MGPS) based on the additive effects of six HPA-axis candidate genes (SKS2, NR3C1, NR3C2, FKBP5). Participants were categorized into distinct trajectories of suicidal ideation based on time-varying changes in their ideation scores. Multivariate logistic regression analyses were conducted to identify predictors of trajectory membership.</div></div><div><h3>Results</h3><div>(1) Five distinct trajectories of suicidal ideation were identified: resistance (52.7 %), persistence (13.1 %), delayed (11.4 %), remission (15.6 %), and relapsing (7.2 %). (2) The combination of HPA-axis MGPS and SLEs showed good predictive accuracy for suicidal ideation trajectories, as indicated by the area under the ROC curve. (3) The interaction between all six stressful life events and HPA-axis MGPS is more predictive of developing persistent trajectories of suicidal ideation. Meanwhile, HPA-axis MGPS interacted with factors such as interpersonal relationships, academic pressure, and loss to better predict the delayed and relapsing suicidal ideation compared to the resistance group.</div></div><div><h3>Conclusions</h3><div>This study suggests that genetic variants associated with the HPA axis exert a polygenic, additive effect on the relationship between stressful life events and longitudinal increases in suicidal ideation.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 288-297"},"PeriodicalIF":4.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and verification of risk prediction model for suicidal attempts of mood disorder based on machine learning","authors":"Yannan Deng ,&nbsp;Jinhe Zhang ,&nbsp;Xinyu Liu ,&nbsp;Qitong Jiang ,&nbsp;Yujie Xing ,&nbsp;Yuxuan Xu ,&nbsp;Guangwei Zhao ,&nbsp;Sha Sha ,&nbsp;Sixiang Liang ,&nbsp;Chen Hu","doi":"10.1016/j.jad.2025.03.107","DOIUrl":"10.1016/j.jad.2025.03.107","url":null,"abstract":"<div><h3>Background</h3><div>Mood disorders (MD) are closely related to suicide attempt (SA). Developing an effective prediction model for SA in MD patients could play a crucial role in the early identification of high-risk groups.</div></div><div><h3>Methods</h3><div>1099 patients with MD were collected to Model construction. 387 MD patients were enrolled for external validate. The least absolute shrinkage and selection operator (LASSO) regression was used to screen features that may be related to SA as predictors. Ten machine learning algorithms were applied to the training set to construct the SA prediction model. The machine learning model with the best sensitivity and stability was selected according to AUC, F1 score, accuracy and other indicators. The locally explanatory technique of Shapley Additive Explanations (SHAP) was used to rank and interpret the importance of features collected in best model to analyze the potential impact of each feature on SA. Meanwhile, to further validate the stability of the model, the sensitivity analysis utilizing k-fold cross-validation and external validate in another center were performed.</div></div><div><h3>Results</h3><div>This study incorporates 8 features. Prediction models was constructed based on 10 different machine learning methods. The results showed that the prediction model constructed by Random Forest (RF) method had good discriminant ability and stability (AUC of Testing = 0.741, AUC of Training = 0.786, AUC of validation = 0.788) and acceptable discriminant. Further, the prediction model showed that the most valuable features for predicting SA were Polarity and previous SA.</div></div><div><h3>Conclusion</h3><div>The RF method can better construct the risk prediction model of SA in MD patients.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 279-287"},"PeriodicalIF":4.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of childhood maltreatment in the association between being left-behind and adolescent anxiety.","authors":"Yun Du ,&nbsp;Xiaoxuan Duan ,&nbsp;Yi Li ,&nbsp;Wancheng Zheng ,&nbsp;Jianghe Chen ,&nbsp;Yujia Cao ,&nbsp;Miao Qu","doi":"10.1016/j.jad.2025.03.130","DOIUrl":"10.1016/j.jad.2025.03.130","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Left-behind and separated from parents are common among Chinese adolescents and many developing countries, which may cause maltreatment and mental disorders, especially anxiety. Nevertheless, the comprehensive study in the prevalence of childhood maltreatment and its role in anxiety among left-behind adolescents is still insufficient.</div></div><div><h3>Methods</h3><div>A nationally representative middle school sample of 32,620 adolescents participated the pen-paper survey regarding demographics, left-behind status and the source of abuse. The Generalized Anxiety Disorder-7 and Chinese version of the Childhood Trauma Questionnaire were used to assess anxiety symptoms and maltreatment experience. The analyses in prevalence, risk factors and mediating effects were preformed in SPSS 27.</div></div><div><h3>Results</h3><div>30,174 valid questionnaires were collected, of which 2748 were left-behind adolescents. 46.4 % of left-behind and 35.6 % of non-left-behind adolescents reported anxiety, and left-behind increased risk of anxiety (OR = 1.180, 95%CI: 1.180–1.286, <em>p</em> &lt; 0.001). In left-behind adolescents, female sex, older age, and maltreatment experience were risk factors of anxiety. Additionally, left-behind adolescents were more likely to suffer serious abuse and all abuse subtypes. The maltreatment almost completely mediated the association between left-behind and anxiety (0.857, 95%bootstrap CI = 0.743, 0.976), of which emotional abuse played the largest role (0.648, CI = 0.547, 0.751), followed by physical neglect, emotional neglect, and sexual abuse.</div></div><div><h3>Conclusion</h3><div>This study revealed the prevalence of anxiety and maltreatment in Chinese left-behind adolescents, and suggested that the maltreatment might significantly mediate the anxiety of left-behind adolescents. This may shed a light on other developing countries where the phenomenon of left-behind adolescents exists.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 430-438"},"PeriodicalIF":4.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderate drinking benefits cognitive health in middle-aged and older Chinese: A latent class growth model analysis based on CHARLS","authors":"Zhaoyang Xie ,&nbsp;Zheng Zhang ,&nbsp;Kaiwen Bi ,&nbsp;Shucai Huang ,&nbsp;Min Zhao ,&nbsp;Jiang Du","doi":"10.1016/j.jad.2025.03.134","DOIUrl":"10.1016/j.jad.2025.03.134","url":null,"abstract":"<div><div>While alcohol use among older population is linked to various health risks, recent studies indicate potential benefits from moderate consumption, highlighting a contentious debate regarding its impact on health in this demographic. This study aims to identify distinct trajectories of alcohol use among middle-aged and older adults in China and examine their associations with multidimensional health outcomes, including cardiovascular, cognitive, and psychological health. This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS), tracking a sample of 10,927 participants (54.33 % female; mean age = 57.61, <em>SD</em> = 8.95) through five waves of data collection. Latent Class Growth Modeling (LCGM) was employed to analyze alcohol use trajectories. Health outcomes were assessed through self-reported health measures and clinical data including lipoprotein levels. Four distinct alcohol use trajectories were identified: Moderate (6.3 %), Decreasing (11.0 %), Increasing (6.9 %), and Constantly Low (75.8 %). The Moderate trajectory was associated with significant higher cognitive scores compared to Increasing (<em>p</em> <em>=</em> .027) and Constantly Low group (<em>p</em> <em>=</em> .012). Moreover, higher levels of high density lipoprotein were linked with the Increasing and Decreasing trajectories, suggesting a protective cardiovascular effect. The findings highlight the complexity of alcohol use behaviors among older adults in China and underscore the need for targeted health interventions. Understanding the nuanced impacts of different drinking patterns on multidimensional health outcomes can aid in developing more effective public health strategies and clinical practices tailored to the needs of aging populations. Further research is recommended to explore the causal relationships and long-term health impacts of these trajectories.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 439-448"},"PeriodicalIF":4.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of a body shape index and depression on mortality in individuals with low sexual frequency","authors":"Tian-Qi Teng ,&nbsp;Meng-Meng Wang ,&nbsp;De-Gang Mo ,&nbsp;Yan-you Xie ,&nbsp;Rui Chen ,&nbsp;Jia-Chao Xu ,&nbsp;Jing Liu ,&nbsp;Hai-Chu Yu","doi":"10.1016/j.jad.2025.03.129","DOIUrl":"10.1016/j.jad.2025.03.129","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with low sexual frequency often experience comorbidities that exacerbate mortality. This article evaluates the predictive value of five body fat anthropometric indicators for all-cause mortality and explores the interaction between obesity and depression in mortality among young and middle-aged individuals with sexual frequency &lt;12 times per year.</div></div><div><h3>Methods</h3><div>This study included participants with a sexual frequency of &lt;12 times per year from the 2015–2016 National Health and Nutrition Examination Survey (NHANES). We assessed the impact of anthropometric indicators and depression on mortality, as well as their synergistic interactions, and further developed an accessible predictive survival model.</div></div><div><h3>Results</h3><div>A total of 4978 participants aged 20–59 were included, with 215 deaths (4.3 %) over 15 years of follow-up. A Body Shape Index (ABSI) showed the strongest association with all-cause mortality, with an AUC of 0.67. Participants with ABSI ≥0.082 had a significantly higher risk of death (HR: 1.87, 95%CI: 1.31–2.68), as did those with depression (HR: 1.86, 95%CI: 1.19–2.92). Interaction analysis revealed a synergistic effect between depression and ABSI, increasing death risk by 293 % when both were present. Significant survival differences were observed between men and women with these risk factors, with median survival rates of 76.3 % and 90.8 %, respectively. The model based on ABSI and depression provided valuable mortality predictions, with AUC of 0.78, 0.77, and 0.77 for 3-year, 5-year, and 10-year survival.</div></div><div><h3>Conclusion</h3><div>ABSI and depression are associated with all-cause mortality in individuals with low sexual frequency, potentially creating a synergistic effect on mortality risk.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 104-112"},"PeriodicalIF":4.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the effects of vagus nerve stimulation on symptom improvement in markedly treatment-resistant major depressive disorder: A RECOVER trial report","authors":"Harold A. Sackeim ,&nbsp;Charles R. Conway ,&nbsp;Scott T. Aaronson ,&nbsp;Mark T. Bunker ,&nbsp;Charles Gordon ,&nbsp;Ying-Chieh (Lisa) Lee ,&nbsp;Olivia Shy ,&nbsp;Shannon Majewski ,&nbsp;Quyen Tran ,&nbsp;A. John Rush","doi":"10.1016/j.jad.2025.03.124","DOIUrl":"10.1016/j.jad.2025.03.124","url":null,"abstract":"<div><h3>Background</h3><div>The RECOVER trial randomized 493 patients with markedly treatment-resistant major depressive disorder to treatment-as-usual with or without active vagus nerve stimulation (VNS Therapy). While the primary outcome measure did not statistically separate the treatment conditions, the field may lack optimal metrics for quantifying symptom improvement in markedly treatment-resistant patients.</div></div><div><h3>Methods</h3><div>This study examined the impact of three factors on sensitivity to clinical improvement across the total RECOVER sample and to differences in the effectiveness of the randomized conditions, systematically varying outcome classification (remission, response, and partial response), observation period (3–12 months, 6–12 months, 10–12 months and last observation), and depression rating scale.</div></div><div><h3>Results</h3><div>Effect sizes for detecting therapeutic change across the total sample and the difference in effectiveness between the randomized groups were markedly higher for partial response than response or remission classifications. Longer observation periods produced larger therapeutic effects across the sample, but the effect sizes for the randomized treatment differences were substantially higher in the final 10–12 month period. The MADRS showed the least sensitivity to change across the sample and between the treatment groups. Using the partial response classification and the 10–12 month observation period, a significant difference between the groups was obtained for 3 of 4 depression scales.</div></div><div><h3>Limitations</h3><div>The findings derive from a retrospective assessment of alternative outcome metrics.</div></div><div><h3>Conclusion</h3><div>In a large randomized controlled trial of VNS for markedly treatment-resistant depression, the magnitude of therapeutic effects and separation of treatment groups differed as a function of outcome classification, measurement period, and rating scale.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 135-145"},"PeriodicalIF":4.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}