Journal of affective disorders最新文献

{"title":"Exposure to childhood parental bereavement and risk of school bullying victimization","authors":"Hailiang Ran ,&nbsp;Jin Lu ,&nbsp;Qiongxian Li ,&nbsp;Yuanyu Shi ,&nbsp;Guiqing Zheng ,&nbsp;Yandie He ,&nbsp;Shuqing Liu ,&nbsp;Yi Xiang ,&nbsp;William Y. Xuan ,&nbsp;Yuanyuan Xiao ,&nbsp;Ziming Xuan","doi":"10.1016/j.jad.2025.03.105","DOIUrl":"10.1016/j.jad.2025.03.105","url":null,"abstract":"<div><h3>Objective</h3><div>Parental bereavement is detrimental to youth mental health, yet its potential impact on youth bullying remains unknown. We aimed to examine the association of early exposure to parental death with school bullying victimization, and further assess whether youth's age when bereavement occurred, sex, and urbanicity modify the association.</div></div><div><h3>Method</h3><div>This study used a large multi-site sample (N = 21,489 youth aged 10–17) from the Mental Health Survey for Children and Adolescents in Yunnan Province, China, 2019 to 2021. Childhood parental bereavement data were based on self-report of any parental bereavement. Current bullying victimization was measured using the Olweus Questionnaire. Logistic regression model accounting for the survey design was used to estimate the association.</div></div><div><h3>Results</h3><div>597 participants (2.8 %) experienced a parental death. 3283 individuals (15.3 %) reported current bullying victimization in the school. Youth's parental bereavement was associated with greater likelihood of bullying victimization (aOR 1.42 [95 % CI 1.12–1.81]) and frequent victimization (aOR = 1.44 [95 % CI 1.08–1.90]). Maternal death, girls, youth from rural areas, and those who experienced bereavement at older ages were more likely to experience bullying victimization. Maternal death was associated with elevated risk of bullying victimization among youth with parental death at older ages, boys, and youth from urban areas.</div></div><div><h3>Conclusions</h3><div>Early exposure to parental bereavement increased the risk of school bullying victimization and frequent victimization. The sex of the deceased parent, age when bereavement occurred, sex of youth participant, and urban-rural residence modified the observed association. Tailored interventions for youth who experienced parental bereavement could consider in addressing school bullying.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 87-93"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hikikomori (social withdrawal) and depression in Korean young adults.","authors":"Su Min Park, Min Jeong Joo, Jae Hyeok Lim, Suk-Yong Jang, Eun-Cheol Park, Min Jin Ha","doi":"10.1016/j.jad.2025.03.125","DOIUrl":"https://doi.org/10.1016/j.jad.2025.03.125","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) is a prevalent mental illness, particularly affecting women. The World Health Organization projects that by 2030, MDD will be the leading cause of disease burden. The phenomenon of hikikomori-initially observed in Japan-is increasingly associated with depression, a key risk factor for which is social isolation. This study analyzed the impact of social withdrawal on depression among South Korean young adults, focusing on (1) the relation between withdrawal duration and causes, and (2) its effect on depression severity.</p><p><strong>Methods: </strong>Data from the 2022 Korean Youth Survey, including 14,966 participants aged 19-34, were used. Depression levels were assessed using the Patient Health Questionnaire-9 (PHQ-9), and multiple logistic regression was conducted to examine the association between hikikomori behavior and depression.</p><p><strong>Results: </strong>The reference group for all analyses was youth who were not socially withdrawn. The association between hikikomori and depression was statistically significant for the two sexes (males: OR: 2.25, 95 % CI: 1.60-3.19; females: OR: 2.34, 95 % CI: 1.63-3.36). Household size influenced depression risk among hikikomori, and sex differences were observed in social withdrawal's effect on suicide risk.</p><p><strong>Conclusion: </strong>This study highlights the link between hikikomori and depression in South Korean youth, with sex-specific differences in depression and suicide risk, suggesting the need for tailored mental health programs. Future research should explore the long-term effects of prolonged social withdrawal through longitudinal studies and conduct cross-cultural comparisons of hikikomori.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy evaluation and facial expressions biomarker of light therapy in youths with subthreshold depression: A randomized control trial study","authors":"Xin Chen ,&nbsp;Lin Liu ,&nbsp;Huan Mei ,&nbsp;Zhendong Jiang ,&nbsp;Wei Yan ,&nbsp;Le Shi ,&nbsp;Xiaoxing Liu ,&nbsp;Kai Yuan ,&nbsp;Yanhua Zhang ,&nbsp;Xiaoyu Luo ,&nbsp;Liguo Zhang ,&nbsp;Yimiao Zhao ,&nbsp;Shuilin Wu ,&nbsp;Bailin Chen ,&nbsp;Jiaqian Yuan ,&nbsp;Zhenyu Liu ,&nbsp;Hanshu Cai ,&nbsp;Shiqiu Meng ,&nbsp;Jie Shi ,&nbsp;Xiangyou Li ,&nbsp;Yanping Bao","doi":"10.1016/j.jad.2025.03.123","DOIUrl":"10.1016/j.jad.2025.03.123","url":null,"abstract":"<div><h3>Background</h3><div>Simpler and more feasible light therapy protocols, and objective indicators for assessing its effectiveness is lacking. We aimed to evaluate the efficacy of light therapy on subthreshold depression (SD) among college students and explore facial expressions as an objective biomarker across different treatment groups.</div></div><div><h3>Methods</h3><div>From September 13, 2021, to January 4, 2022, college students with SD were recruited from a university in Hubei Province, randomly assigned to Bright Light Therapy (BLT) group (10,000 lx), Dim Light Therapy (DLT) group (200 lx), or Waiting List Control (WLC) group (no intervention). Self-reported questionnaire and facial expressions were assessed for all participants before and after intervention. Repeated measures ANOVA and logistic regression were conducted to compare baseline and post-intervention differences among three groups.</div></div><div><h3>Results</h3><div>135 participants were enrolled and 121 participants completed the study. Depression symptom and sleep quality scores significantly decreased in both BLT and DLT groups (<em>P</em> &lt; 0.001), while no significant changes were observed in WLC group. BLT (OR, 4.50; 95 % CI, 1.11–18.27; <em>P</em> = 0.035) and DLT group (OR, 4.17; 95 % CI, 1.04–16.79; <em>P</em> = 0.045) had higher efficacy rates than WLC group. For facial expressions, DLT group showed significant increases in two happy-related facial action units (AU) including AU14 values (positive, negative and neutral stimuli) and AU26 values (neutral and negative stimuli). BLT group showed a significant decrease in fear-related AU20 values under negative stimuli (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Light therapy improves depressive symptoms and sleep quality in individuals with SD, and facial expressions can serve as an objective biomarker to support its effectiveness.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 357-365"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of Dietary Quality Index-International (DQII) score with anxiety and depression: Results of a population-based study","authors":"Niloufar Abdollahpour ,&nbsp;Najmeh Seifi ,&nbsp;Gelare Koochakpoor ,&nbsp;Abolfazl Rashid ,&nbsp;Ali Mottaghi Moghaddam Shahri ,&nbsp;Gordon A. Ferns ,&nbsp;Majid Ghayour-Mobarhan","doi":"10.1016/j.jad.2025.03.119","DOIUrl":"10.1016/j.jad.2025.03.119","url":null,"abstract":"<div><h3>Background</h3><div>Recent evidence indicates a relationship between diet quality and prevalent psychiatric disorders, though, the nature of this association remains unclear. This study aimed to investigate the association between the Dietary Quality Index-International (DQI<img>I) score and the severity of depression and anxiety.</div></div><div><h3>Methods</h3><div>This cross-sectional research involved 6472 individuals aged 35–65 from the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study. Dietary intake was assessed using a validated food frequency questionnaire (FFQ), and dietary quality was evaluated using the DQI-I score. The severity scores of depression and anxiety were measured through the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI).</div></div><div><h3>Results</h3><div>Participants in the highest tertile of DQI-I had lower anxiety and depression severity scores than those in lower tertiles (<em>P</em> &lt; 0.001). After adjusting for confounders, the association remained significant only for depression score (OR = 0.85; 95 % CI: 0.73–0.98; <em>p</em> = 0.02). Among DQI-I components, only overall balance was significantly associated with depression score (OR = 0.86; 95 % CI: 0.75–1.00; <em>p</em> = 0.04). Higher variety and adequacy scores were linked to lower odds of anxiety score (OR = 0.75; 95 % CI: 0.61–0.93; <em>p</em> &lt; 0.01 and OR = 0.79; 95 % CI: 0.66–0.96; p = 0.02).</div></div><div><h3>Limitations</h3><div>The cross-sectional design restricts causal inference, FFQs introduce recall bias, and unmeasured confounding remains a possibility.</div></div><div><h3>Conclusion</h3><div>Individuals in the highest DQI-I tertile had lower odds of severe depression score. Overall balance correlated significantly with depression severity score, while higher variety and adequacy scores were linked to reduced severe anxiety score.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 449-455"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between RAR and the prevalence and prognosis of depression: A population-based study","authors":"Xiao-Feng Zhu ,&nbsp;Yu-Qi Hu ,&nbsp;Zhi-Wei Long ,&nbsp;Ming-Zhu Cao","doi":"10.1016/j.jad.2025.03.100","DOIUrl":"10.1016/j.jad.2025.03.100","url":null,"abstract":"<div><h3>Background</h3><div>Depression has become a significant public health issue. The red blood cell distribution width to albumin ratio (RAR) is regarded as a reliable marker of inflammation and nutritional status, yet the association between them remains unknown. Therefore, this study aims to evaluate the association between RAR and depression.</div></div><div><h3>Methods</h3><div>28,737 participants were included in the National Health and Nutrition Examination Survey 2005–2018. The weighted multivariate logistic regression and Cox regression explored the relationship between RAR and the prevalence and mortality of depression. Restricted cubic spline (RCS) detected nonlinear relationships and threshold effects. The stratified analysis explored potential interaction variables.</div></div><div><h3>Results</h3><div>In the cross-sectional study, 2519 participants (7.67 %) had depression. Weighted multivariate logistic regression showed RAR was independently associated depression (OR = 1.26, 95 % CI = 1.12, 1.42, <em>P</em> &lt; 0.001). In the cohort study, there were 301 cases of all-cause mortality (9.94 %) in depression population, including 77 cases of cardiovascular mortality (2.66 %). Weighted multivariate Cox regression analysis presented that RAR was related to higher all-cause mortality (HR = 1.98, 95 % CI = 1.62, 2.42, <em>P</em> &lt; 0.001) and cardiovascular mortality (HR = 1.73, 95 % CI = 1.19, 2.51, <em>P</em> = 0.004) in the depression population. Subgroup analysis showed that RAR was consistently related to the prevalence and mortality of depression across all subgroups (all <em>P</em> &lt; 0.05). RCS revealed that the relationship between RAR and depression was nonlinear (P for nonlinear = 0.011), while the association between RAR and all-cause mortality was linear (P for nonlinear = 0.245).</div></div><div><h3>Conclusions</h3><div>RAR is significantly associated with the prevalence and prognosis of depression. Nevertheless, more investigation is required to elucidate the underlying processes.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 1-9"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends in prevalence for depressive disorders among women of childbearing age: Age-period-cohort analysis 2021","authors":"Xiang Yan ,&nbsp;Dequan Wu ,&nbsp;Ruojie Li ,&nbsp;Yile Wu ,&nbsp;Xiaoqian Hu ,&nbsp;Xueping Wang ,&nbsp;Kai Huang ,&nbsp;Tao Zhu ,&nbsp;Qiyu Zhu ,&nbsp;Liang Fang ,&nbsp;Guoping Ji","doi":"10.1016/j.jad.2025.03.108","DOIUrl":"10.1016/j.jad.2025.03.108","url":null,"abstract":"<div><h3>Background</h3><div>Depressive disorders (DD) are significant mood disorders with a notable female preference, especially affecting the well-being of women of childbearing age (WCBA). This population with DD was notably associated with severe complications during the perinatal period, leading to unfavourable maternal mortality and morbidity.</div></div><div><h3>Methods</h3><div>This study extracted data from the Global Burden of Disease Study (GBD) 2021. We analysed the number of cases, calculated the age-standardized prevalence rate, and performed the age-period-cohort (APC) model to estimate prevalence trends and age, period, and cohort effects from 1992 to 2021.</div></div><div><h3>Results</h3><div>From 1992 to 2021, the global number of WCBA with DD surged by 59.46 %, reaching 121 million cases up to 2021. India, China, and the USA had over 40 million prevalence cases, accounting for 36.17 % of global prevalence. The global net drift of DD prevalence among WCBA was −0.13 % per year (95 % CI: −0.17 % to −0.09 %). Age effects demonstrated similar patterns that the prevalence risk rose with age. All SDI regions showed unfavourable prevalence risks surging in the period of 2017–2021. The cohort risk of prevalence increased globally in younger generations after the 1987–1996 cohort.</div></div><div><h3>Conclusion</h3><div>Although the overall temporal trend (net drift) presented a downward trend in DD prevalence among WCBA over the past three decades, the prevalence cases had continued to rise with unfavourable period and cohort effects. Since COVID-19 triggered a massive increase in the prevalence of depressive disorders worldwide, there is an urgent need for stakeholders and policy makers to strengthen mental health-care systems.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 124-134"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural dynamics of social anxiety during and after anxiety-provoking and relaxation-inducing: A task and resting-state fMRI study.","authors":"Yujin Ko, Hesun Erin Kim, Byung-Hoon Kim, Kyunghee Ham, Seungmin Lee, Bohyun Park, Jae-Jin Kim","doi":"10.1016/j.jad.2025.03.104","DOIUrl":"https://doi.org/10.1016/j.jad.2025.03.104","url":null,"abstract":"<p><strong>Background: </strong>Social anxiety disorder (SAD) is marked by intense fear of social situations and negative evaluation. This study investigated neural effects of SAD-specific imagery scripts and their relationships with Brief Fear of Negative Evaluation (BFNE).</p><p><strong>Methods: </strong>Thirty-six SAD and 32 healthy controls underwent four five-minute fMRI runs: anxiety-provoking imagery, rest, relaxing imagery, and rest. The order of imageries was counterbalanced. Functional connectivity analysis and connectome-based predictive modeling with respect to BFNE were performed using six seed regions, including the bilateral amygdala, left hypothalamus, bilateral dorsomedial prefrontal cortex (DMPFC), left ventromedial PFC (VMPFC), and left posterior cingulate cortex (PCC).</p><p><strong>Results: </strong>Group × task interaction effects were found in connectivity of left amygdala-right cerebellum, left PCC-bilateral superior frontal gyrus, and left PCC-right posterior middle temporal gyrus, and group × engagement effects were discovered in left hypothalamus-bilateral DMPFC and left VMPFC-right DMPFC couplings. Group × task × engagement interactions highlighted aberrant functional connections of right amygdala-left VMPFC, DMPFC-left DLPFC, and left VMPFC-bilateral supplementary motor area in SAD. Patterns of connectivity predicted the BFNE scores in various segments of imagery conditions.</p><p><strong>Limitations: </strong>Patient's medication, physiological measures were not considered. Noisy nature of fMRI could have interfered participants from focusing.</p><p><strong>Conclusions: </strong>Our results revealed disrupted functional connections associated with emotion dysregulation and overly self-referent thinking in SAD. Markedly, patients showed maladaptive responses related to relaxation-inducing blocks, challenging the expected relaxation response. Overall findings emphasized inappropriate engagements of various processes in relaxing circumstances that do not overtly involve social anxiety to be associated with symptomatology.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerometer-derived “weekend warrior” physical activity, genetic susceptibility, and risk of depression and anxiety: The UK Biobank study","authors":"Yahang Liu ,&nbsp;Chen Huang ,&nbsp;Kecheng Wei ,&nbsp;Ruilang Lin ,&nbsp;Ye Yao ,&nbsp;Guoyou Qin ,&nbsp;Yongfu Yu","doi":"10.1016/j.jad.2025.03.110","DOIUrl":"10.1016/j.jad.2025.03.110","url":null,"abstract":"<div><h3>Importance</h3><div>Guidelines recommend 150 min per week (min/wk) or more of moderate to vigorous physical activity (MVPA) for mental health benefits. However, the relative effects of concentrated against more evenly distributed activity patterns remain unclear.</div></div><div><h3>Objective</h3><div>We aimed to examine associations of the accelerometer-derived “weekend warrior (WW)” pattern (MVPA concentrated within 1 to 2 days) vs MVPA spread more evenly with risk of depression and anxiety.</div></div><div><h3>Design, setting, and participants</h3><div>This prospective cohort study included 84,570 participants with accelerometer data identified from the UK Biobank.</div></div><div><h3>Exposures</h3><div>Three MVPA patterns were compared: active WW (MVPA ≥150 min/wk and ≥50 % of total MVPA within 1 to 2 days), active regular (MVPA ≥150 min/wk but not active WW), and inactive (MVPA &lt;150 min/wk).</div></div><div><h3>Main outcomes and measures</h3><div>Cox regression was used to assess the association of MVPA patterns with depression and anxiety, and whether the association differed by different levels of sedentary time (≤6, 7–12, ≥13 h/day) and light physical activity (≤60, 61–150, ≥151 min/day). We also evaluated the combined impact of MVPA patterns and genetic susceptibility on depression and anxiety.</div></div><div><h3>Results</h3><div>During the follow-up of up to 9.40 years, 2098 and 2699 cases of depression and anxiety were identified, respectively. Compared with inactive group, active regular and active WW groups exhibited similarly reduced risks of depression (active regular: HR, 0.74 [95 % CI, 0.66–0.84]; active WW: 0.72 [0.65–0.80]) and anxiety (active regular: 0.77 [0.69–0.86]; active WW: 0.72 [0.66–0.79]). The impact of active regular and active WW groups on depression and anxiety was more pronounced among individuals with excessive sedentary time (≥13 h/day) and insufficient light physical activity (≤60 min/day). Individuals with low genetic risk and active regular (depression: 0.64 [0.48–0.87]; anxiety: 0.62 [0.49–0.79]), as well as low genetic risk and active WW groups (depression: 0.60 [0.47–0.77]; anxiety: 0.59 [0.48–0.72]) exhibited the lowest risks of depression and anxiety compared to those with high genetic risk and inactive group.</div></div><div><h3>Conclusions and relevance</h3><div>Adherence to active physical activity, regardless of physical activity concentrated within 1 to 2 days or more evenly distributed, may help reduce depression and anxiety risks across a population with different genetic risk profiles.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 55-62"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common genetic basis and causality between central nervous system disease and cancer","authors":"Shiheng Tan ,&nbsp;Ning Zhao ,&nbsp;Qingzhen Fu ,&nbsp;Lin Zhu ,&nbsp;Ding Zhang ,&nbsp;Lijing Gao ,&nbsp;Zesong Cheng ,&nbsp;Zinan Li ,&nbsp;Depei Zhang ,&nbsp;Weiwei Bao ,&nbsp;Yanlong Liu ,&nbsp;Fan Wang ,&nbsp;Binbin Cui ,&nbsp;Yashuang Zhao","doi":"10.1016/j.jad.2025.03.122","DOIUrl":"10.1016/j.jad.2025.03.122","url":null,"abstract":"<div><div>The epidemiological associations between central nervous system diseases and cancers have been widely studied, but the shared genetic basis and etiology between these joint phenotypes remain unclear. To explore this issue, we utilized genome-wide association study summary data to investigate the shared genetic architecture and causality between 10 central nervous system diseases and 14 cancers.</div><div>We employed multiple statistical genetic approaches, including global and local genetic correlation, Mendelian randomization, shared loci and genes, and shared tissues and cell-types to systematically and robustly explore the common genetic basis and causal relationships between central nervous system diseases and cancers.</div><div>Our results revealed genetic correlations between schizophrenia and both lung cancer and breast cancer, including estrogen receptor-positive breast cancer, as well as between neuroticism and both lung cancer and ovarian cancer, including serous ovarian cancer. We found causal relationships between schizophrenia and lung cancer (OR = 1.14, <em>P</em> = 0.009) and breast cancer (OR = 1.05, <em>P</em> = 3.00 × 10⁻⁵). When the whole genome was partitioned, significant local correlations of schizophrenia with breast cancer and lung cancer were further discovered within 14 specific genomic regions. Using cross-trait meta-analysis, we identified 24 pleiotropic loci associated with the two joint phenotypes. Using summary-data-based Mendelian randomization, we further identified eight functional genes shared between schizophrenia and both breast cancer and lung cancer, neuroticism and ovarian cancer. Additionally, we observed consistent patterns of single-nucleotide polymorphism heritability enrichment for schizophrenia and lung cancer in T lymphocytes.</div><div>Our study provides insights into the genetic underpinnings and causal relationships of comorbidities between central nervous system diseases and cancers.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 347-356"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights on underlying shared genetic architectures and causality of underweight and depression in East Asian populations","authors":"Ming Chen ,&nbsp;Zhen Xiao ,&nbsp;Yueya Wang ,&nbsp;Wanqi Ou ,&nbsp;Cailan Hou ,&nbsp;Hao-Zhang Huang","doi":"10.1016/j.jad.2025.03.126","DOIUrl":"10.1016/j.jad.2025.03.126","url":null,"abstract":"<div><h3>Background</h3><div>Extensive evidence links a lower body mass index (BMI) to higher odds of depression in individuals of East Asian ancestry, differing from patterns observed in European populations. However, the shared genetic etiology underlying underweight and depression remains unclear in East Asian populations.</div></div><div><h3>Method</h3><div>Utilizing large-scale genome-wide association study (GWAS) data, we investigated the shared genetics between BMI (<em>N</em> = 323,298) and depression traits (<em>N</em> = 286,052) through linkage disequilibrium score regression, cross-trait meta-analysis and colocalization analysis. Additionally, we evaluated causal associations using bidirectional Mendelian randomization (MR) analysis.</div></div><div><h3>Results</h3><div>We found a significantly negative genetic correlation between BMI and depression (rg = −0.19, <em>P</em> = 0.002). The cross-trait analysis identified 26 shared risk SNPs, including <em>FTO</em> and more. Moreover, the risk gene <em>AGBL4</em> showed evidence of colocalization. Using the MR method, lower BMI was associated with higher odds of depression in individuals of East Asian ancestry (OR: 1.14, 95 % CI: 1.02 to 1.28, <em>P</em> = 0.021) but no reverse causal effect was observed.</div></div><div><h3>Conclusions</h3><div>Our study indicates a genetic correlation, shared risk genes, and causality between underweight and depression in East Asian populations. These findings provide insights into the potential mechanisms behind their comorbidity and inform the future development of therapeutics for East Asian populations.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 226-229"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}