中性粒细胞百分比与白蛋白比率介导了美国成年人抑郁症与全因死亡率之间的关联:来自NHANES 2009-2018的证据。

IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY
Journal of affective disorders Pub Date : 2025-11-15 Epub Date: 2025-06-20 DOI:10.1016/j.jad.2025.119736
Kunxiu Wang, Gaofeng Liu, Yuchen Pan, Siyu Li, Xiaoling Zhu, Hui Qu, Xuesong Liang, Song Chen, Wenbin Fu
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引用次数: 0

摘要

背景:抑郁症显著降低了全球数亿人的生活质量。有证据表明抑郁症、中性粒细胞百分比与白蛋白比率(NPAR)和全因死亡率(ACM)之间存在关联。然而,它们之间的相互关系并没有被阐明。本研究旨在揭示NPAR是否介导抑郁与ACM之间的相关性。方法:基于2009 - 2018年国家健康与营养检查调查(NHANES)数据进行横断面研究。ACM数据收集截止到2019年12月31日。利用加权二元逻辑回归和广义线性回归模型来揭示抑郁评分、NPAR和ACM之间的两两关联。通过中介分析评估NPAR对抑郁与ACM之间关系的潜在中介作用。结果:共纳入18709名受试者。在完全调整模型中,抑郁评分(OR[95 % CI]: 1.035[1.012, 1.058])和NPAR (OR[95 % CI]: 1.15[1.108, 1.194])与ACM呈显著正相关。抑郁评分与NPAR呈正相关(β[95 % CI]: 0.014[0.001, 0.026])。NPAR介导了5.27 %的抑郁与ACM的总关联。亚组分析显示,NPAR的中介作用在特定人群中更为突出。结论:在美国成年人中,抑郁症显著增加ACM的风险,这种关系是由NPAR介导的。NPAR的中介作用因性别、年龄、种族和健康状况而异。这些发现填补了现有文献的空白。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The neutrophil percentage-to-albumin ratio mediates the association between depression and all-cause mortality in U.S. adults: Evidence from NHANES 2009-2018.

Background: Depression significaantly reduces the quality of life for hundreds of millions of people globally. Evidence suggests associations among depression, the neutrophil percentage-to-albumin ratio (NPAR), and all-cause mortality (ACM). However, the interrelationship was not elucidated. This study aimed to unveil whether NPAR mediates the correlation between depression and ACM.

Methods: A cross-sectional study was carried out based on data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018. ACM data were collected up to December 31, 2019. Weighted binary logistic regression and generalized linear regression models were leveraged to unravel pairwise associations among depression scores, NPAR, and ACM. Mediation analysis was performed to evaluate the potential mediating effects of NPAR on the relationship between depression and ACM.

Results: 18,709 participants were encompassed. In the fully adjusted model, depression scores (OR [95 % CI]: 1.035 [1.012, 1.058]) and NPAR (OR [95 % CI]: 1.15 [1.108, 1.194]) were significantly positively linked to ACM. Depression scores were positively correlated with NPAR (β [95 % CI]: 0.014 [0.001, 0.026]). NPAR mediated 5.27 % of the total association between depression and ACM. Subgroup analyses revealed that the mediating effect of NPAR was more prominent in specific populations.

Conclusion: Among U.S. adults, depression significantly increases the risk of ACM, and this relationship is mediated by NPAR. The mediating effect of NPAR varied by sex, age, race, and health status. These findings fill gaps in the existing literature.

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来源期刊
Journal of affective disorders
Journal of affective disorders 医学-精神病学
CiteScore
10.90
自引率
6.10%
发文量
1319
审稿时长
9.3 weeks
期刊介绍: The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.
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