Association between folate intake and suicidal ideation: NHANES 2005-2018 and Mendelian randomization.

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-06-18 DOI:10.1016/j.jad.2025.119730

Ling Feng, Shandie Li, Chaorui Li

{"title":"Association between folate intake and suicidal ideation: NHANES 2005-2018 and Mendelian randomization.","authors":"Ling Feng, Shandie Li, Chaorui Li","doi":"10.1016/j.jad.2025.119730","DOIUrl":null,"url":null,"abstract":"Background: Previous findings indicated that there was an association between folate intake and suicidal behaviors. Nevertheless, whether folate intake influences suicidal ideation remains inconclusive. Consequently, this research focuses on investigating the link between folate intake and suicidal ideation.Methods: The data utilized came from the National Health and Nutrition Examination Survey (NHANES) database, with a coverage period of 2005-2018. We examined the correlation between folate intake and suicidal ideation by applying weighted logistic regression, restricted cubic spline (RCS) models, and subgroup analysis. Mendelian randomization (MR) was utilized as an instrumental variable method to evaluate the potential causality.Results: The NHANES analysis revealed a non-linear inverse relationship between folate intake and suicidal ideation (P for nonlinear: 0.014). After adjusting for all covariates, participants in the fourth quartile of folate intake demonstrated a 38 % diminished risk of suicidal ideation relative to those in the first quartile, for each incremental unit of folate intake (OR: 0.62, 95%CI: 0.44-0.89). Subgroup analysis revealed that the relationship between folate intake and suicidal ideation remained consistent across gender, race, smoking status, diabetes, hypertension and depression (P for interaction>0.05). Nevertheless, the Mendelian randomization (MR) analysis was unable to show causality between folate intake and suicidal ideation (OR: 0.944, 95%CI: 0.788-1.131, P: 0.533).Conclusions: An inverse connection was observed between folate intake and suicidal ideation, but no causal relationship was established.","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119730"},"PeriodicalIF":4.9000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jad.2025.119730","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Previous findings indicated that there was an association between folate intake and suicidal behaviors. Nevertheless, whether folate intake influences suicidal ideation remains inconclusive. Consequently, this research focuses on investigating the link between folate intake and suicidal ideation.

Methods: The data utilized came from the National Health and Nutrition Examination Survey (NHANES) database, with a coverage period of 2005-2018. We examined the correlation between folate intake and suicidal ideation by applying weighted logistic regression, restricted cubic spline (RCS) models, and subgroup analysis. Mendelian randomization (MR) was utilized as an instrumental variable method to evaluate the potential causality.

Results: The NHANES analysis revealed a non-linear inverse relationship between folate intake and suicidal ideation (P for nonlinear: 0.014). After adjusting for all covariates, participants in the fourth quartile of folate intake demonstrated a 38 % diminished risk of suicidal ideation relative to those in the first quartile, for each incremental unit of folate intake (OR: 0.62, 95%CI: 0.44-0.89). Subgroup analysis revealed that the relationship between folate intake and suicidal ideation remained consistent across gender, race, smoking status, diabetes, hypertension and depression (P for interaction>0.05). Nevertheless, the Mendelian randomization (MR) analysis was unable to show causality between folate intake and suicidal ideation (OR: 0.944, 95%CI: 0.788-1.131, P: 0.533).

Conclusions: An inverse connection was observed between folate intake and suicidal ideation, but no causal relationship was established.

查看原文本刊更多论文

叶酸摄入量与自杀意念之间的关系：NHANES 2005-2018和孟德尔随机化。

背景：先前的研究结果表明叶酸摄入量与自杀行为之间存在关联。然而，叶酸摄入是否影响自杀意念仍然没有定论。因此，本研究的重点是调查叶酸摄入量和自杀意念之间的联系。方法：使用的数据来自国家健康与营养检查调查（NHANES）数据库，覆盖期为2005-2018年。我们通过应用加权逻辑回归、受限三次样条（RCS）模型和亚组分析来检验叶酸摄入量与自杀意念之间的相关性。使用孟德尔随机化（MR）作为工具变量方法来评估潜在的因果关系。结果：NHANES分析显示叶酸摄入量与自杀意念呈非线性负相关（非线性P值：0.014）。在对所有协变量进行调整后，叶酸摄入量每增加一个单位，第四个四分位数的参与者的自杀意念风险相对于第一个四分位数的参与者降低了38% % （OR: 0.62, 95%CI: 0.44-0.89）。亚组分析显示，叶酸摄入量与自杀意念的关系在性别、种族、吸烟状况、糖尿病、高血压和抑郁之间保持一致（交互作用P < 0.05）。然而，孟德尔随机化（MR）分析无法显示叶酸摄入量与自杀意念之间的因果关系（OR: 0.944, 95%CI: 0.788-1.131, P: 0.533）。结论：叶酸摄入与自杀意念呈负相关，但未建立因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.