早期性交、生理性别和性取向对抑郁风险的复杂影响。

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-07-18 DOI:10.1016/j.jad.2025.119938

Peilin Zou , Jiajun Li , Liangkai Chen , Man Liu , Yucong Zhang

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引用次数: 0

摘要

目的：了解生理性别、性取向和早期性行为对抑郁症的影响。方法：使用2005 - 2016年全国健康与营养检查调查数据库中的数据。第一次性行为在18岁 之前被定义为早期性行为。非异性恋的参与者被认为是性少数。结果：这项研究招募了15231名参与者。在调整混杂因素后，过早性交仅是女性异性恋者抑郁的危险因素（OR = 1.66,95 % CI: 1.28, 2.16）。女性生理性别是异性恋个体抑郁的危险因素，与早期性行为无关(无早期性行为：OR = 2.77,95 % CI: 1.30, 5.92；早期性交：OR = 1.64,95 % CI: 1.08, 2.50)。然而，女性生理性别与性少数群体患抑郁症的风险没有显著关联。除了没有早期性行为的男性个体外，性少数状态是抑郁症的危险因素。有趣的是，对于早期发生性行为的生物学上的女性个体，同性恋与较低的抑郁风险相关（OR = 0.28,95 % CI: 0.09, 0.85）。结论：早期性行为、生理性别和性取向对抑郁风险的影响是相互依存的。

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The complex impacts of early sexual intercourse, biological sex, and sexual orientation on the risk of depression

Objective

To better understand the impacts of biological sex, sexual orientation and early sexual intercourse on depression.

Methods

Data from the National Health and Nutrition Examination Survey database from 2005 to 2016 were used. First sexual intercourse before 18 years of age was defined as early sexual intercourse. Participants who were not heterosexual were considered sexual minorities.

Results

This study enrolled 15,231 participants. After adjusting for confounders, early sexual intercourse was a risk factor for depression only for female heterosexual (OR = 1.66, 95 % CI: 1.28, 2.16). Female biological sex was a risk factor for depression in heterosexual individuals, regardless of early sexual intercourse (without early sexual intercourse: OR = 2.77, 95 % CI: 1.30, 5.92; with early sexual intercourse: OR = 1.64, 95 % CI: 1.08, 2.50). However, female biological sex was not significantly associated with the risk of depression in sexual minorities. Sexual minority status was a risk factor for depression, except for male individuals without early sexual intercourse. Interestingly, for biological female individuals with early sexual intercourse, homosexuality was associated with a lower risk of depression (OR = 0.28, 95 % CI: 0.09, 0.85).

Conclusion

The impacts of early sexual intercourse, biological sex and sexual orientation on the risk of depression are contingent on each other.

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.