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IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-07-01 Epub Date: 2026-07-27 DOI: 10.1016/S2452-302X(26)00165-8
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引用次数: 0
From Cardiomyocyte Proliferation to Regenerative Ecosystems 从心肌细胞增殖到再生生态系统。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-06-01 Epub Date: 2026-06-22 DOI: 10.1016/j.jacbts.2026.101597
Matthias Nahrendorf MD, PhD (Editor-in-Chief, JACC: Basic to Translational Science)
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引用次数: 0
Atrial Fibrillation Beyond the Atrium 心房外心房颤动。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-06-01 Epub Date: 2026-06-22 DOI: 10.1016/j.jacbts.2026.101600
James Cranley BM BCh, PhD
{"title":"Atrial Fibrillation Beyond the Atrium","authors":"James Cranley BM BCh, PhD","doi":"10.1016/j.jacbts.2026.101600","DOIUrl":"10.1016/j.jacbts.2026.101600","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 6","pages":"Article 101600"},"PeriodicalIF":8.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Perspective on a Genetically Altered Model of SARS-CoV-2 Myocarditis SARS-CoV-2心肌炎基因改变模型的新视角：LDLR-OPN轴
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-06-01 Epub Date: 2026-06-22 DOI: 10.1016/j.jacbts.2026.101601
Madeleine W. Cunningham PhD, Leslie T. Cooper Jr. MD
{"title":"A Novel Perspective on a Genetically Altered Model of SARS-CoV-2 Myocarditis","authors":"Madeleine W. Cunningham PhD, Leslie T. Cooper Jr. MD","doi":"10.1016/j.jacbts.2026.101601","DOIUrl":"10.1016/j.jacbts.2026.101601","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 6","pages":"Article 101601"},"PeriodicalIF":8.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strengths and Limitations of the Renal Locoregional Perfusion Platform 肾局部灌注平台的优势与局限性。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-06-01 Epub Date: 2026-06-22 DOI: 10.1016/j.jacbts.2026.101589
Yosu Luque Rincon MD, PhD
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引用次数: 0
Recognizing Early Career Translational Investigators 认识早期职业翻译研究者。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-06-01 Epub Date: 2026-06-22 DOI: 10.1016/j.jacbts.2026.101612
Matthias Nahrendorf MD (Editor-in-Chief: JACC: Basic to Translational Science)
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引用次数: 0
Increased Arrhythmic Risk in Obesity Is Transduced by Adipose Tissue–Derived Extracellular Vesicles 肥胖患者心律失常风险增加是由脂肪组织来源的细胞外囊泡转导的。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-06-01 Epub Date: 2026-06-22 DOI: 10.1016/j.jacbts.2026.101577
Worawan B. Limpitikul MD, PhD, Marta Garcia-Contreras PhD, Paul Spangler MD, Michael J. Betti PhD, Quanhu Sheng PhD, Steffen Pabel MD, Samuel Sossalla MD, Emeli Chatterjee PhD, Ling Xiao PhD, Patrick T. Ellinor MD, PhD, Eric R. Gamazon PhD, Ravi Shah MD, Saumya Das MD, PhD
{"title":"Increased Arrhythmic Risk in Obesity Is Transduced by Adipose Tissue–Derived Extracellular Vesicles","authors":"Worawan B. Limpitikul MD, PhD,&nbsp;Marta Garcia-Contreras PhD,&nbsp;Paul Spangler MD,&nbsp;Michael J. Betti PhD,&nbsp;Quanhu Sheng PhD,&nbsp;Steffen Pabel MD,&nbsp;Samuel Sossalla MD,&nbsp;Emeli Chatterjee PhD,&nbsp;Ling Xiao PhD,&nbsp;Patrick T. Ellinor MD, PhD,&nbsp;Eric R. Gamazon PhD,&nbsp;Ravi Shah MD,&nbsp;Saumya Das MD, PhD","doi":"10.1016/j.jacbts.2026.101577","DOIUrl":"10.1016/j.jacbts.2026.101577","url":null,"abstract":"<div><div>Obesity drives atrial fibrillation and ventricular arrhythmias, yet whether direct fat-heart communication mediates this risk is unknown. The authors demonstrate that human atrial myocytes from obese individuals exhibit prolonged action potential duration, a pro-arrhythmic phenotype reproduced by treating induced pluripotent stem cell–derived cardiomyocytes with visceral adipose tissue–derived extracellular vesicles (VAT EVs) from obese donors. VAT EVs also impaired calcium handling, activated cardiac fibroblasts, and shifted macrophages toward a pro-inflammatory activation state—collectively promoting an arrhythmogenic substrate. Using a transgenic adipose-specific EV-tracking mouse model, the authors confirmed preferential adipose-to-myocardial EV trafficking in obese vs lean mice in vivo. Transcriptome-wide association studies anchored on VAT EV–induced gene expression changes identified causal links to QT interval and atrial fibrillation in large genome-wide association studies. Pharmacologic inhibition of TRPC3, an ion channel upregulated by VAT EVs, restored action potential duration toward normal, identifying a novel therapeutic target in obesity-associated arrhythmia.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 6","pages":"Article 101577"},"PeriodicalIF":8.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac Impulse Propagation 心脏脉冲传播：一个综合的观点。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-06-01 Epub Date: 2026-06-22 DOI: 10.1016/j.jacbts.2026.101588
Zhilin Qu PhD, Kalyanam Shivkumar MD, PhD
{"title":"Cardiac Impulse Propagation","authors":"Zhilin Qu PhD,&nbsp;Kalyanam Shivkumar MD, PhD","doi":"10.1016/j.jacbts.2026.101588","DOIUrl":"10.1016/j.jacbts.2026.101588","url":null,"abstract":"<div><div>Two principal mechanisms have been proposed to explain impulse propagation in cardiac tissue. The first is low-resistance gap-junctional coupling, which explains many experimental observations but does not fully account for all findings, such as those in connexin 43-knockout mouse experiments. The second is ephaptic coupling, in which myocytes interact via electric fields in the narrow extracellular cleft between cells and that can, in principle, support conduction even when effective gap-junctional conductance is low or absent. In this review, we summarize the theoretical insights from computational modeling studies and experimental evidence supporting ephaptic coupling. Although experimental evidence for ephaptic coupling remains indirect and limited, we argue that, as with all biological systems, the heart may utilize redundant coupling mechanisms to ensure the robustness of conduction and normal cardiac function. In other words, gap junction coupling and ephaptic coupling are not mutually exclusive but instead function in a synergistic and complementary way to optimize cardiac function across a large physiological range.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 6","pages":"Article 101588"},"PeriodicalIF":8.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simplified and Refined Murine Model of Reversible Aortic Constriction for Characterizing Cardiac Functional Recovery 简化和改进小鼠可逆性主动脉缩窄模型以表征心功能恢复。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-06-01 Epub Date: 2026-06-22 DOI: 10.1016/j.jacbts.2026.101575
Elnaz Ghajar-Rahimi PhD, Pierre Sicard PhD, Ava Flynn BSc, Laura Castel MSc, Craig J. Goergen PhD, Thomas Moore-Morris PhD
{"title":"Simplified and Refined Murine Model of Reversible Aortic Constriction for Characterizing Cardiac Functional Recovery","authors":"Elnaz Ghajar-Rahimi PhD,&nbsp;Pierre Sicard PhD,&nbsp;Ava Flynn BSc,&nbsp;Laura Castel MSc,&nbsp;Craig J. Goergen PhD,&nbsp;Thomas Moore-Morris PhD","doi":"10.1016/j.jacbts.2026.101575","DOIUrl":"10.1016/j.jacbts.2026.101575","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 6","pages":"Article 101575"},"PeriodicalIF":8.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Full Issue PDF 完整版PDF
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-06-01 Epub Date: 2026-06-22 DOI: 10.1016/S2452-302X(26)00135-X
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引用次数: 0
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