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Adipose–Cardiac Crosstalk in Obesity-Related Atrial Fibrillation 肥胖相关心房颤动中的脂肪-心脏串扰：细胞外囊泡的新作用。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-06-01 Epub Date: 2026-06-22 DOI: 10.1016/j.jacbts.2026.101598
Naveed Akbar PhD, Svetlana Reilly MD, PhD
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引用次数: 0
FOXC1 and Smooth Muscle Cell Plasticity in Human Atherosclerosis 人动脉粥样硬化中FOXC1与平滑肌细胞可塑性的关系。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-06-01 Epub Date: 2026-06-22 DOI: 10.1016/j.jacbts.2026.101593
Michal Mokry MD, PhD
{"title":"FOXC1 and Smooth Muscle Cell Plasticity in Human Atherosclerosis","authors":"Michal Mokry MD, PhD","doi":"10.1016/j.jacbts.2026.101593","DOIUrl":"10.1016/j.jacbts.2026.101593","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 6","pages":"Article 101593"},"PeriodicalIF":8.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Full Issue PDF 完整版PDF
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-05-01 Epub Date: 2026-05-26 DOI: 10.1016/S2452-302X(26)00104-X
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引用次数: 0
Editorial Board/Officers Page 编辑委员会/官员页
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-05-01 Epub Date: 2026-05-26 DOI: 10.1016/S2452-302X(26)00097-5
{"title":"Editorial Board/Officers Page","authors":"","doi":"10.1016/S2452-302X(26)00097-5","DOIUrl":"10.1016/S2452-302X(26)00097-5","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 5","pages":"Article 101578"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systems Biology Identifies TARS2 as a Cardiomyocyte Regulator of Mitochondrial Oxidative Stress in Dilated Cardiomyopathy 系统生物学鉴定TARS2是扩张型心肌病线粒体氧化应激的心肌细胞调节剂。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-05-01 Epub Date: 2026-04-27 DOI: 10.1016/j.jacbts.2026.101535
Liming Chen PhD , Xuan Li PhD , Xiaolei Sun PhD , Xiaolin Wang PhD , Jian Wu PhD , Enyong Su PhD , Shijun Wang PhD , Huan Sun MD, PhD , Leilei Ma PhD , Yunzeng Zou MD, PhD
{"title":"Systems Biology Identifies TARS2 as a Cardiomyocyte Regulator of Mitochondrial Oxidative Stress in Dilated Cardiomyopathy","authors":"Liming Chen PhD ,&nbsp;Xuan Li PhD ,&nbsp;Xiaolei Sun PhD ,&nbsp;Xiaolin Wang PhD ,&nbsp;Jian Wu PhD ,&nbsp;Enyong Su PhD ,&nbsp;Shijun Wang PhD ,&nbsp;Huan Sun MD, PhD ,&nbsp;Leilei Ma PhD ,&nbsp;Yunzeng Zou MD, PhD","doi":"10.1016/j.jacbts.2026.101535","DOIUrl":"10.1016/j.jacbts.2026.101535","url":null,"abstract":"<div><div>Dilated cardiomyopathy (DCM), a leading cause of heart failure, is characterized by progressive cardiomyocyte (CM) loss and mitochondrial dysfunction; yet, the molecular drivers of mitochondrial oxidative stress (MitOS) remain unclear. By integrating bulk, single-cell, and spatial transcriptomics with machine learning, we identified threonyl-tRNA synthetase 2 (TARS2) as a CM-enriched regulator of MitOS. TARS2 was consistently up-regulated in human DCM hearts and associated with apoptotic signaling and enhanced macrophage crosstalk. Functional studies demonstrated that TARS2 overexpression disrupted mitochondrial homeostasis, triggered excessive mitochondrial reactive oxygen species, and induced CM apoptosis, whereas genetic inhibition restored mitochondrial function, reduced apoptosis, and improved cardiac performance. These findings uncover TARS2 as a novel regulator of mitochondrial dysfunction and pathological remodeling in DCM, providing both mechanistic insights and therapeutic implications, and establish a systems biology framework for translational discovery of disease targets in cardiovascular medicine.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 5","pages":"Article 101535"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyclophilin D at the Heart of Neonatal Hypoxia 亲环蛋白D在新生儿缺氧中的作用。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-05-01 Epub Date: 2026-05-26 DOI: 10.1016/j.jacbts.2026.101570
Joseph W. Gordon
{"title":"Cyclophilin D at the Heart of Neonatal Hypoxia","authors":"Joseph W. Gordon","doi":"10.1016/j.jacbts.2026.101570","DOIUrl":"10.1016/j.jacbts.2026.101570","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 5","pages":"Article 101570"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148030673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the Mitochondrial Translation-Stress Axis 解码线粒体翻译-应激轴：TARS2是DCM发病机制的缺失环节吗？
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-05-01 Epub Date: 2026-05-26 DOI: 10.1016/j.jacbts.2026.101565
Sharon Zeldin BS, Junichi Sadoshima MD, PhD
{"title":"Decoding the Mitochondrial Translation-Stress Axis","authors":"Sharon Zeldin BS,&nbsp;Junichi Sadoshima MD, PhD","doi":"10.1016/j.jacbts.2026.101565","DOIUrl":"10.1016/j.jacbts.2026.101565","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 5","pages":"Article 101565"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148030652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editing the Plaque 编辑斑块：针对动脉粥样硬化中致病性平滑肌细胞的免疫疗法。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-05-01 Epub Date: 2026-05-26 DOI: 10.1016/j.jacbts.2026.101559
Matthias Nahrendorf MD, PhD (Editor-in-Chief, JACC: Basic to Translational Science)
{"title":"Editing the Plaque","authors":"Matthias Nahrendorf MD, PhD (Editor-in-Chief, JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2026.101559","DOIUrl":"10.1016/j.jacbts.2026.101559","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 5","pages":"Article 101559"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148030604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Potential of Apelin-Targeted Therapeutic Lymphangiogenesis Therapy for Viral Myocarditis apelin靶向性淋巴血管生成治疗病毒性心肌炎的潜力。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-05-01 Epub Date: 2026-05-26 DOI: 10.1016/j.jacbts.2026.101556
Yuuki Shimizu MD, PhD
{"title":"The Potential of Apelin-Targeted Therapeutic Lymphangiogenesis Therapy for Viral Myocarditis","authors":"Yuuki Shimizu MD, PhD","doi":"10.1016/j.jacbts.2026.101556","DOIUrl":"10.1016/j.jacbts.2026.101556","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 5","pages":"Article 101556"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148030614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To B-E3 or Not to B-E3 去B-E3还是不去B-E3: MuRF1和结蛋白-2在连接蛋白调控中的作用。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-05-01 Epub Date: 2026-05-26 DOI: 10.1016/j.jacbts.2026.101568
Iona M.A. Palmer BA, Helen E. Collins PhD
{"title":"To B-E3 or Not to B-E3","authors":"Iona M.A. Palmer BA,&nbsp;Helen E. Collins PhD","doi":"10.1016/j.jacbts.2026.101568","DOIUrl":"10.1016/j.jacbts.2026.101568","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 5","pages":"Article 101568"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148030600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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