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JACC: Basic to Translational Science最新文献

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Cardiomyocyte-Derived Apelin Rescues Viral Myocarditis-Induced Cardiac Lymphatic Dysfunction and Remodeling 心肌细胞来源的Apelin拯救病毒性心肌炎诱导的心脏淋巴功能障碍和重塑。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-05-01 Epub Date: 2026-04-27 DOI: 10.1016/j.jacbts.2026.101537
Yuan-Nan Lin MD , Jing Xu MD , Yi-Hao Wu MD , Mao-Xiang Jin MD , Yu-Tian Wang MD , Yu-Qing Wu MD , Hao-Hua Zhan MD , Xin-Ge Qian MD , Zhe-Ning Wang MD , Lei-Wang MD , Yue-Chun Li MD
{"title":"Cardiomyocyte-Derived Apelin Rescues Viral Myocarditis-Induced Cardiac Lymphatic Dysfunction and Remodeling","authors":"Yuan-Nan Lin MD ,&nbsp;Jing Xu MD ,&nbsp;Yi-Hao Wu MD ,&nbsp;Mao-Xiang Jin MD ,&nbsp;Yu-Tian Wang MD ,&nbsp;Yu-Qing Wu MD ,&nbsp;Hao-Hua Zhan MD ,&nbsp;Xin-Ge Qian MD ,&nbsp;Zhe-Ning Wang MD ,&nbsp;Lei-Wang MD ,&nbsp;Yue-Chun Li MD","doi":"10.1016/j.jacbts.2026.101537","DOIUrl":"10.1016/j.jacbts.2026.101537","url":null,"abstract":"<div><div>Recent research has indicated that cardiac lymphatic vessels (CLVs) serve as a direct drainage route into the mediastinal lymph nodes for inflammation resolution. However, the role of CLVs in coxsackievirus B3–induced acute viral myocarditis (AVMC) remains unknown. In this study, we found that AVMC in mice promoted pathological cardiac lymphangiogenesis while impairing CLV-mediated drainage, leading to heart inflammation and dysfunction. Overexpression of apelin in cardiomyocytes improved CLV integrity and promoted effective lymph drainage to decrease inflammatory responses and enhance cardiac function. In vitro studies revealed that apelin stabilizes lymphatic endothelial cadherin and zonula occludens 1 to enhance lymphatic function via the AKT signaling pathway. Moreover, pre-existing lymphatic defects induced by blocking vascular endothelial growth factor receptor 3 partially diminished the benefits of cardiomyocyte-derived apelin overexpression in AVMC. Taken together, these data indicate that functional CLVs restored by cardiomyocyte-derived apelin facilitate inflammation resolution and improve heart dysfunction in AVMC. Thus, CLV-based therapeutic strategies may serve as a novel approach for alleviating AVMC heart damage.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 5","pages":"Article 101537"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognizing Early Career Translational Investigators 认识早期职业翻译研究者。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-05-01 Epub Date: 2026-05-26 DOI: 10.1016/j.jacbts.2026.101572
Matthias Nahrendorf MD (Editor-in-Chief: JACC: Basic to Translational Science)
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引用次数: 0
Metabolic Reprogramming of Fibroblasts by Extracellular Vesicles 细胞外囊泡对成纤维细胞的代谢重编程：纤维化的治疗轴。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-04-01 Epub Date: 2026-04-27 DOI: 10.1016/j.jacbts.2026.101538
Yu Tian MS , Andrew A. Gibb PhD
{"title":"Metabolic Reprogramming of Fibroblasts by Extracellular Vesicles","authors":"Yu Tian MS ,&nbsp;Andrew A. Gibb PhD","doi":"10.1016/j.jacbts.2026.101538","DOIUrl":"10.1016/j.jacbts.2026.101538","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 4","pages":"Article 101538"},"PeriodicalIF":8.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pillars of Peer Review 同行评议的支柱。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-04-01 Epub Date: 2026-04-27 DOI: 10.1016/j.jacbts.2026.101531
Matthias Nahrendorf MD, PhD (Editor-in-Chief, JACC: Basic to Translational Science)
{"title":"Pillars of Peer Review","authors":"Matthias Nahrendorf MD, PhD (Editor-in-Chief, JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2026.101531","DOIUrl":"10.1016/j.jacbts.2026.101531","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 4","pages":"Article 101531"},"PeriodicalIF":8.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is Obesity a Major Driver of Primary Aldosteronism? 肥胖是原发性醛固酮增多症的主要驱动因素吗？
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-04-01 Epub Date: 2026-04-27 DOI: 10.1016/j.jacbts.2026.101541
John E. Hall PhD , Ana C.M. Omoto PhD , Michael E. Hall MD, MS
{"title":"Is Obesity a Major Driver of Primary Aldosteronism?","authors":"John E. Hall PhD ,&nbsp;Ana C.M. Omoto PhD ,&nbsp;Michael E. Hall MD, MS","doi":"10.1016/j.jacbts.2026.101541","DOIUrl":"10.1016/j.jacbts.2026.101541","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 4","pages":"Article 101541"},"PeriodicalIF":8.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Full Issue PDF 完整版PDF
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-04-01 Epub Date: 2026-04-27 DOI: 10.1016/S2452-302X(26)00069-0
{"title":"Full Issue PDF","authors":"","doi":"10.1016/S2452-302X(26)00069-0","DOIUrl":"10.1016/S2452-302X(26)00069-0","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 4","pages":"Article 101551"},"PeriodicalIF":8.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147797883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methylated PIH1D1 as a Heart-Specific Biomarker for Anthracycline-Induced Cardiac Remodeling in Breast Cancer Patients 甲基化pihd1作为蒽环类药物诱导乳腺癌患者心脏重构的心脏特异性生物标志物
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-04-01 Epub Date: 2026-03-11 DOI: 10.1016/j.jacbts.2026.101510
Po-Yen Hsu MS , Wan-Hong Huang MS , Yi-Yun Lee BS , Robert Passier PhD , Szu-Chin Li MD, PhD , Chong-Lin Hong MD, PhD , Shih-Kai Hung MD, PhD , Hong-Yi Lin MD, PhD , Chun-Hung Lin MD , Chen-Yu Chien MD , Yi-Da Li MD, MS , Hsiang-Chun Lee MD, PhD , Laurent Désaubry PhD , Canan G. Nebigil PhD , Michael W.Y. Chan PhD
{"title":"Methylated PIH1D1 as a Heart-Specific Biomarker for Anthracycline-Induced Cardiac Remodeling in Breast Cancer Patients","authors":"Po-Yen Hsu MS ,&nbsp;Wan-Hong Huang MS ,&nbsp;Yi-Yun Lee BS ,&nbsp;Robert Passier PhD ,&nbsp;Szu-Chin Li MD, PhD ,&nbsp;Chong-Lin Hong MD, PhD ,&nbsp;Shih-Kai Hung MD, PhD ,&nbsp;Hong-Yi Lin MD, PhD ,&nbsp;Chun-Hung Lin MD ,&nbsp;Chen-Yu Chien MD ,&nbsp;Yi-Da Li MD, MS ,&nbsp;Hsiang-Chun Lee MD, PhD ,&nbsp;Laurent Désaubry PhD ,&nbsp;Canan G. Nebigil PhD ,&nbsp;Michael W.Y. Chan PhD","doi":"10.1016/j.jacbts.2026.101510","DOIUrl":"10.1016/j.jacbts.2026.101510","url":null,"abstract":"<div><div>Anthracyclines, key chemotherapy agents, pose cardiotoxicity risks. In a 3-year study of 89 breast cancer patients treated with doxorubicin or epirubicin, more than 50% showed reduced left ventricular ejection fraction and progressive ventricular dilation. Although troponin-I flagged acute damage, it failed to predict long-term remodeling. Using a human methylome atlas, researchers identified 33 heart-specific methylated CpG sites and validated methylated <em>PIH1D1</em> (m<em>PIH1D1</em>) as a novel biomarker. Elevated m<em>PIH1D1</em> levels strongly correlated with ventricular dilation but not left ventricular ejection fraction decline, indicating its sensitivity to early cardiac remodeling. m<em>PIH1D1</em> may complement troponin-I in risk assessment and cardiotoxicity management for patients undergoing anthracycline-based chemotherapy.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 4","pages":"Article 101510"},"PeriodicalIF":8.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147387943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Tet2 in Medial Vascular Calcification Tet2在内侧血管钙化中的作用。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-04-01 Epub Date: 2026-04-27 DOI: 10.1016/j.jacbts.2026.101533
Yixiao Zhu MS , Li Lin MS , Xiaoxia Wei PhD
{"title":"The Role of Tet2 in Medial Vascular Calcification","authors":"Yixiao Zhu MS ,&nbsp;Li Lin MS ,&nbsp;Xiaoxia Wei PhD","doi":"10.1016/j.jacbts.2026.101533","DOIUrl":"10.1016/j.jacbts.2026.101533","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 4","pages":"Article 101533"},"PeriodicalIF":8.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JACC: Basic to Translational Science 2025 Thomas Force Young Investigator Award Winner JACC：基础到转化科学2025年Thomas Force青年研究者奖得主
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-04-01 Epub Date: 2026-04-27 DOI: 10.1016/j.jacbts.2026.101529
Matthias Nahrendorf MD, PhD (Editor-in-Chief: JACC: Basic to Translational Science)
{"title":"JACC: Basic to Translational Science 2025 Thomas Force Young Investigator Award Winner","authors":"Matthias Nahrendorf MD, PhD (Editor-in-Chief: JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2026.101529","DOIUrl":"10.1016/j.jacbts.2026.101529","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 4","pages":"Article 101529"},"PeriodicalIF":8.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147797881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium Channel mRNA Binding Proteins 钠通道mRNA结合蛋白。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-04-01 Epub Date: 2026-04-27 DOI: 10.1016/j.jacbts.2026.101546
Barry London MD, PhD
{"title":"Sodium Channel mRNA Binding Proteins","authors":"Barry London MD, PhD","doi":"10.1016/j.jacbts.2026.101546","DOIUrl":"10.1016/j.jacbts.2026.101546","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 4","pages":"Article 101546"},"PeriodicalIF":8.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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