JACC: Basic to Translational Science最新文献

Disruption of Notch1 and Gata5 in Mice Leads to Congenital Aortic Valve Disease 小鼠中Notch1和Gata5的破坏导致先天性主动脉瓣疾病

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-31 DOI: 10.1016/j.jacbts.2025.101354

Jun Yasuhara MD, PhD , Mona Aljuhani PhD , Talita Z. Choudhury PhD , Anupama Rao PhD , Sara Conroy PhD , Yukie Ueyama DVM , Stephanie LaHaye PhD , Karlee Schultz MS , Emily M. Cameron MS , Sathiya N. Manivannan PhD , Uddalak Majumdar PhD , Vidu Garg MD

引用次数: 0

An Integrated Pressure-Volume Loop and Pulmonary Artery Catheter 集成压力-容量环和肺动脉导管

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-30 DOI: 10.1016/j.jacbts.2025.101326

M. Imran Aslam MD , Aleksandra B. Gruslova PhD , Luis A. Diaz Sanmartin MS , Drew Nolen MS , James J. Elliott DVM , Alexander J. Moody PhD , Joel E. Michalek PhD , Vivek P. Jani BS, MS , Fawaz Alenezi MD, MSc , Clay Heighten MD , Jonathan W. Valvano PhD , Marc D. Feldman MD

引用次数: 0

Single Ascending-Dose Study of Selective ErbB4 Agonist JK07 in Heart Failure With Reduced Ejection Fraction 选择性ErbB4激动剂JK07单次递增剂量治疗心力衰竭伴射血分数降低的研究

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-29 DOI: 10.1016/j.jacbts.2025.101352

W.H. Wilson Tang MD , Johannes Steiner MD , Mahwash Kassi MD , Matthew T. Wheeler MD , Aferdita Spahillari MD, MPH , Nancy K. Sweitzer MD, PhD , Justin L. Grodin MD, MPH , Neal Solomon MD , Shalabh Singhal MD , Amanda M.G. McEwen MS , Samuel L. Murphy MD

{"title":"Single Ascending-Dose Study of Selective ErbB4 Agonist JK07 in Heart Failure With Reduced Ejection Fraction","authors":"W.H. Wilson Tang MD , Johannes Steiner MD , Mahwash Kassi MD , Matthew T. Wheeler MD , Aferdita Spahillari MD, MPH , Nancy K. Sweitzer MD, PhD , Justin L. Grodin MD, MPH , Neal Solomon MD , Shalabh Singhal MD , Amanda M.G. McEwen MS , Samuel L. Murphy MD","doi":"10.1016/j.jacbts.2025.101352","DOIUrl":"10.1016/j.jacbts.2025.101352","url":null,"abstract":"<div><div>This first-in-human, phase 1, double-blind, placebo-controlled study evaluated the safety, tolerability, immunogenicity, pharmacokinetics, and exploratory efficacy of a selective ErbB4 agonist, JK07, in patients with heart failure with reduced ejection fraction (HFrEF). In these patients on optimal goal-directed medical therapy, JK07 was generally safe and well tolerated at dose levels up to 0.09 mg/kg. There was a trend toward increased incidence and severity of treatment-emergent adverse events observed at the highest dose of 0.27 mg/kg. Consistent with prolonged effects seen with transient exposure to neuregulin-1 in previous phase 1 investigations, improvements in left ventricular ejection fraction lasting up to 180 days after infusion were observed. These findings support continued clinical investigation of JK07 in heart failure. (Study of JK07 in Subjects With Heart Failure With Reduced Ejection Fraction; <span><span>NCT04210375</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 9","pages":"Article 101352"},"PeriodicalIF":8.4,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD137 Signaling Modulates Vein Graft Atherosclerosis by Driving T-Cell Activation and Regulating Intraplaque Angiogenesis CD137信号通过驱动t细胞激活和调节斑块内血管生成来调节移植物动脉粥样硬化

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-29 DOI: 10.1016/j.jacbts.2025.101323

Alwin de Jong MD, PhD , Thijs J. Sluiter BSc , Hendrika A.B. Peters BSc , Alec Lamens MSc , J. Wouter Jukema MD, PhD , Ramon Arens PhD , Paul.H.A. Quax PhD , Margreet R. de Vries PhD

引用次数: 0

Harnessing Mitochondrial Transplantation to Target Vascular Inflammation in Cardiovascular Health 利用线粒体移植靶向心血管健康中的血管炎症

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-25 DOI: 10.1016/j.jacbts.2025.101331

Natalia Matiuto BS , Brandon Applewhite PhD , Nicola Habash BS , Ana Martins MS , Bowen Wang PhD , Bin Jiang PhD

{"title":"Harnessing Mitochondrial Transplantation to Target Vascular Inflammation in Cardiovascular Health","authors":"Natalia Matiuto BS , Brandon Applewhite PhD , Nicola Habash BS , Ana Martins MS , Bowen Wang PhD , Bin Jiang PhD","doi":"10.1016/j.jacbts.2025.101331","DOIUrl":"10.1016/j.jacbts.2025.101331","url":null,"abstract":"<div><div>Mitochondrial dysfunction is a key contributor to vascular inflammation in many cardiovascular diseases. This review explores mitochondrial transplantation as a promising strategy for addressing mitochondrial dysfunction and vascular inflammation. We discuss mitochondrial dysfunction across different vascular cell types and current clinical management strategies, highlighting the need for novel approaches that directly target mitochondrial health. We also present recent progress in mitochondrial transplantation across cardiac, neurovascular, and peripheral vascular applications in preclinical settings, as well as ongoing clinical trials. Important technical considerations, such as mitochondria sourcing, delivery routes, and storage, are discussed to facilitate future translation. By reinstating mitochondrial health and hence mitigating vascular inflammation, mitochondrial transplantation holds the potential to provide novel, targeted therapies for cardiovascular diseases, ultimately improving patient outcomes, reducing disease progression, and addressing unmet medical needs in vascular health. The translation of this technology into clinical practice could offer significant advances in the treatment of a wide range of cardiovascular conditions.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 8","pages":"Article 101331"},"PeriodicalIF":8.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periostin is a Pivotal Target of microRNA-150-5p in Cardiac Fibroblast Activation and Chronic Myocardial Infarction 骨膜蛋白是microRNA-150-5p在心肌成纤维细胞活化和慢性心肌梗死中的关键靶点

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-25 DOI: 10.1016/j.jacbts.2025.101330

Taiki Hayasaka MD, PhD , Bruno Moukette PhD , Marisa N. Sepúlveda PhD , Satoshi Kawaguchi MD, PhD , Tatsuya Aonuma MD, PhD , Hamedane Moustapha MS , Lei Yang PhD , Meena S. Madhur MD, PhD , Suthat Liangpunsakul MD , Il-man Kim PhD

{"title":"Periostin is a Pivotal Target of microRNA-150-5p in Cardiac Fibroblast Activation and Chronic Myocardial Infarction","authors":"Taiki Hayasaka MD, PhD , Bruno Moukette PhD , Marisa N. Sepúlveda PhD , Satoshi Kawaguchi MD, PhD , Tatsuya Aonuma MD, PhD , Hamedane Moustapha MS , Lei Yang PhD , Meena S. Madhur MD, PhD , Suthat Liangpunsakul MD , Il-man Kim PhD","doi":"10.1016/j.jacbts.2025.101330","DOIUrl":"10.1016/j.jacbts.2025.101330","url":null,"abstract":"<div><div>Our prior studies have revealed that miR-150-5p (miR-150) attenuated cardiac dysfunction in mice, which overexpressed a long noncoding RNA called myocardial infarction–associated transcript during myocardial infarction or harbored cardiac-specific abrogation of β-arrestin–mediated β<sub>1</sub>-adrenergic receptor signaling during chronic catecholamine stimulation. Although previous studies have shown the importance of miR-150 in heart failure, details surrounding its actions remain elusive in part because of (1) the lack of detailed mechanistic insight by which this small noncoding RNA induces myocardial protection and (2) the absence of definitive studies using appropriate mouse models to establish its direct functional relationship with key downstream targets. In the current study, we provide strong evidence that fibrotic periostin is a significant downstream target of miR-150 repression in ischemic mouse hearts. To the best of our knowledge, this is the first study to directly establish the functional link between miR-150 and periostin in murine myocardial infarction and primary adult human cardiac fibroblast activation.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 8","pages":"Article 101330"},"PeriodicalIF":8.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cartilage Oligomeric Matrix Protein, a Potential Biomarker for Thoracic Aortic Dissection 软骨寡聚基质蛋白：胸主动脉夹层的潜在生物标志物

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-25 DOI: 10.1016/j.jacbts.2025.101346

Levon M. Khachigian PhD, DSc , Jonathan Golledge MChir

引用次数: 0

TRPM7 Kinase and Mitochondrial Dysfunction in Diabetic Heart Failure With Preserved Ejection Fraction 糖尿病性心力衰竭伴射血分数保留的TRPM7激酶和线粒体功能障碍

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-24 DOI: 10.1016/j.jacbts.2025.101350

Norimichi Koitabashi MD, PhD

引用次数: 0

Ufmylation-Mediated Unfolded Protein Response as An Innovative Therapeutic Target in Peripartum Cardiomyopathy. ufmylation介导的未折叠蛋白反应作为围产期心肌病的创新治疗靶点。

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-22 DOI: 10.1016/j.jacbts.2025.101332

Debabrata Chowdhury, Guo-Chang Fan

引用次数: 0

The Reduction of COMP Serves as a Predictor for Warning of Aortic Dissection Progression COMP的降低可作为主动脉夹层进展的预警指标

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-17 DOI: 10.1016/j.jacbts.2025.101329

Zhuofan Li BS , Ze Gong PhD , Weihao Li MD , Yanghui Chen PhD , Rongbo Dai PhD , Shiyu Yang BS , Yufei Chen PhD , Fang Yu MS , Yi Fu MBBS, PhD , Wei Li MD , Dao Wen Wang MD, PhD , Yiting Jia PhD , Wei Kong MD, PhD

引用次数: 0