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JACC: Basic to Translational Science最新文献

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Reviving Hearts, Restoring Lives
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.01.007
He Zhang MD , Qian Wang MSc , Xiyu Zhu MD , Yunxing Xue MD , Jiaxian Wang MD, PhD , Dongjin Wang MD, PhD
{"title":"Reviving Hearts, Restoring Lives","authors":"He Zhang MD , Qian Wang MSc , Xiyu Zhu MD , Yunxing Xue MD , Jiaxian Wang MD, PhD , Dongjin Wang MD, PhD","doi":"10.1016/j.jacbts.2025.01.007","DOIUrl":"10.1016/j.jacbts.2025.01.007","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 253-255"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decorin and Right Ventricular Failure in Pulmonary Hypertension
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2024.11.007
Katrin Schäfer MD
{"title":"Decorin and Right Ventricular Failure in Pulmonary Hypertension","authors":"Katrin Schäfer MD","doi":"10.1016/j.jacbts.2024.11.007","DOIUrl":"10.1016/j.jacbts.2024.11.007","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 342-344"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When Facts Become Forbidden
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.02.003
Douglas L. Mann MD (Editor-in-Chief, JACC: Basic to Translational Science)
{"title":"When Facts Become Forbidden","authors":"Douglas L. Mann MD (Editor-in-Chief, JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2025.02.003","DOIUrl":"10.1016/j.jacbts.2025.02.003","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 402-404"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Battery Powered and Minimally Invasive Bi-Atrial Pressure Monitoring System to Manage Heart Failure Patients
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.01.013
Suresh Gurunathan MS, MBA , Rishi Puri MD, PhD
{"title":"Battery Powered and Minimally Invasive Bi-Atrial Pressure Monitoring System to Manage Heart Failure Patients","authors":"Suresh Gurunathan MS, MBA , Rishi Puri MD, PhD","doi":"10.1016/j.jacbts.2025.01.013","DOIUrl":"10.1016/j.jacbts.2025.01.013","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 264-266"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognizing Early Career Translational Investigators
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.02.002
Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)
{"title":"Recognizing Early Career Translational Investigators","authors":"Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2025.02.002","DOIUrl":"10.1016/j.jacbts.2025.02.002","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Page 401"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EPA Induces an Anti-Inflammatory Transcriptome in T Cells, Implicating a Triglyceride-Independent Pathway in Cardiovascular Risk Reduction
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2024.09.002
Nathalie A. Reilly MSc , Koen F. Dekkers MSc , Jeroen Molenaar MSc , Sinthuja Arumugam MSc , Thomas B. Kuipers BSc , Yavuz Ariyurek BSc , Marten A. Hoeksema PhD , J. Wouter Jukema MD, PhD , Bastiaan T. Heijmans PhD
{"title":"EPA Induces an Anti-Inflammatory Transcriptome in T Cells, Implicating a Triglyceride-Independent Pathway in Cardiovascular Risk Reduction","authors":"Nathalie A. Reilly MSc ,&nbsp;Koen F. Dekkers MSc ,&nbsp;Jeroen Molenaar MSc ,&nbsp;Sinthuja Arumugam MSc ,&nbsp;Thomas B. Kuipers BSc ,&nbsp;Yavuz Ariyurek BSc ,&nbsp;Marten A. Hoeksema PhD ,&nbsp;J. Wouter Jukema MD, PhD ,&nbsp;Bastiaan T. Heijmans PhD","doi":"10.1016/j.jacbts.2024.09.002","DOIUrl":"10.1016/j.jacbts.2024.09.002","url":null,"abstract":"<div><div>Twice-daily intake of purified eicosapentaenoic acid (EPA) reduces atherosclerotic cardiovascular disease risk in patients with high triglycerides, but its exact mechanism remains unclear. We exposed non-activated CD4<sup>+</sup> T cells to 100μM EPA, oleic acid, palmitic acid, or control, and conducted RNA and ATAC-sequencing after 48 hours. EPA exposure downregulated immune response-related genes like <em>HLA-DRA</em>, <em>CD69</em>, and <em>IL2RA</em>, and upregulated oxidative stress prevention genes like <em>NQO1</em>. Transcription factor footprinting showed decreased GATA3 and PU.1, and increased REV-ERB. These effects were specific to EPA, suggesting it induces an anti-inflammatory transcriptomic landscape in CD4<sup>+</sup> T cells, contributing to its observed cardiovascular benefits.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 383-395"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Pathways of Action of Eicosapentaenoic Acid (EPA)
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2024.10.010
Deepak L. Bhatt MD, MPH, MBA , Peter Libby MD , R. Preston Mason PhD, MBA
{"title":"Emerging Pathways of Action of Eicosapentaenoic Acid (EPA)","authors":"Deepak L. Bhatt MD, MPH, MBA ,&nbsp;Peter Libby MD ,&nbsp;R. Preston Mason PhD, MBA","doi":"10.1016/j.jacbts.2024.10.010","DOIUrl":"10.1016/j.jacbts.2024.10.010","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 396-400"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Full Issue PDF
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/S2452-302X(25)00104-4
{"title":"Full Issue PDF","authors":"","doi":"10.1016/S2452-302X(25)00104-4","DOIUrl":"10.1016/S2452-302X(25)00104-4","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages I-CLXI"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing the 2025 THT Shark Tank Innovation Competition Special Issue
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.02.012
Michael I. Brener MD, MS , Grzegorz L. Kaluza MD, PhD , Daniel Burkhoff MD PhD
{"title":"Introducing the 2025 THT Shark Tank Innovation Competition Special Issue","authors":"Michael I. Brener MD, MS ,&nbsp;Grzegorz L. Kaluza MD, PhD ,&nbsp;Daniel Burkhoff MD PhD","doi":"10.1016/j.jacbts.2025.02.012","DOIUrl":"10.1016/j.jacbts.2025.02.012","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 247-249"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2024.11.011
Naaleum Song PhD , Eunhye Ji PhD , Jeong Eun Yu BS , Kyoung-Hee Choi BS , Dae-Hee Kim MD, PhD , Jong-Min Song MD, PhD , Duk-Hyun Kang MD, PhD , Jae-Kwan Song MD, PhD , Jiyoung Yu PhD , Kyunggon Kim PhD , Sahmin Lee MD, PhD , Elena Aikawa MD, PhD
{"title":"Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification","authors":"Naaleum Song PhD ,&nbsp;Eunhye Ji PhD ,&nbsp;Jeong Eun Yu BS ,&nbsp;Kyoung-Hee Choi BS ,&nbsp;Dae-Hee Kim MD, PhD ,&nbsp;Jong-Min Song MD, PhD ,&nbsp;Duk-Hyun Kang MD, PhD ,&nbsp;Jae-Kwan Song MD, PhD ,&nbsp;Jiyoung Yu PhD ,&nbsp;Kyunggon Kim PhD ,&nbsp;Sahmin Lee MD, PhD ,&nbsp;Elena Aikawa MD, PhD","doi":"10.1016/j.jacbts.2024.11.011","DOIUrl":"10.1016/j.jacbts.2024.11.011","url":null,"abstract":"<div><div>Aortic stenosis (AS) is a severe heart valve disease marked by calcification, leading to heart failure. This study examined mitochondrial function in human aortic valve interstitial cells isolated from patients with AS and tested spermidine, an autophagy inducer as AS treatment. Spermidine treatment reduced fibrosis and calcification in human aortic valve interstitial cells and improved these features in spermidine-treated mice. The AKT-TP53-DNMT1-PPARG pathway was implicated, and DNA methyltransferase 1 inhibition by 5-azacytidine enhanced mitochondrial biogenesis by reducing mitochondrial DNA hypermethylation. These findings suggest that spermidine or DNA methyltransferase 1 inhibition could prevent aortic valve disease by improving mitochondrial function.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 345-366"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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