JACC: Basic to Translational Science最新文献

{"title":"Minimally Invasive Aortic Regurgitation Surgery","authors":"Jinyun Zhu PhD, MD , Chen Gao PhD , Yibin Wang PhD","doi":"10.1016/j.jacbts.2025.101348","DOIUrl":"10.1016/j.jacbts.2025.101348","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 10","pages":"Article 101348"},"PeriodicalIF":8.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SECTM1 Regulates Monocyte Levels and Is Associated With Incident Coronary Heart Disease","authors":"Usman A. Tahir MD ,&nbsp;Daniel Cruz MD ,&nbsp;Dongxiao Shen MS ,&nbsp;Gaurav Tiwari MS ,&nbsp;Jing Liu PhD ,&nbsp;Matthew Huber MD ,&nbsp;Christopher Chan MS ,&nbsp;Shuliang Deng MS ,&nbsp;Mark D. Benson MD ,&nbsp;Jeremy Robbins MD ,&nbsp;Zsu Zsu Chen MD ,&nbsp;Laurie Farrell BS ,&nbsp;Lynette Ekunwe MS ,&nbsp;Michael Hall MD ,&nbsp;Bruce M. Psaty MD ,&nbsp;James S. Floyd MD ,&nbsp;Aarti Asnani MD ,&nbsp;Filip K. Swirski PhD ,&nbsp;James G. Wilson MD ,&nbsp;Robert E. Gerszten MD","doi":"10.1016/j.jacbts.2025.101378","DOIUrl":"10.1016/j.jacbts.2025.101378","url":null,"abstract":"<div><div>Proteomic profiling may provide insights into new biomarkers and pathways in coronary heart disease (CHD). We profiled ∼1,300 proteins in 1,967 Black individuals in the Jackson Heart Study and found Secreted and Transmembrane Protein 1 (SECTM1), a monocyte chemoattractant, to be our top novel finding associated with incident CHD. We validated our findings in the Cardiovascular Health Study. The top variant (rs116473040) associated with SECTM1 was associated with circulating monocyte percentage of white blood cells in a genomic database. In vivo studies demonstrated that recombinant SECTM1a increased the proportion of proatherogenic Ly6Chi monocytes, suggesting a pathway by which SECTM1 may contribute to CHD.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 10","pages":"Article 101378"},"PeriodicalIF":8.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Model of Cardiac Remodeling by a Minimally Invasive Aortic Regurgitation Surgery in Mice","authors":"Xiang Li PhD ,&nbsp;Jian Wu PhD ,&nbsp;Le Kang PhD ,&nbsp;Xuan Li PhD ,&nbsp;Weijiang Tan PhD ,&nbsp;Shuang Zheng MS ,&nbsp;Jianguo Jia BS ,&nbsp;Shijun Wang PhD ,&nbsp;Chunjie Yang BS ,&nbsp;Xuecong Ren BS ,&nbsp;Honghua Chen BS ,&nbsp;Hui Gong PhD ,&nbsp;Kuan Cheng PhD ,&nbsp;Huan Sun MD, PhD ,&nbsp;Fenghua Yang PhD ,&nbsp;Yunzeng Zou MD, PhD","doi":"10.1016/j.jacbts.2025.101324","DOIUrl":"10.1016/j.jacbts.2025.101324","url":null,"abstract":"<div><div>Although the prevalence of aortic regurgitation (AR), which causes eccentric remodeling and valvular heart disease (VHD), is increasing, suitable animal research models remain lacking. To address this issue, we established the first efficient, real-time visualized minimally invasive aortic regurgitation surgery mouse model by performing echocardiography-guided aortic valve tear using a modified insulin needle. The clinically relevant features of this AR model were verified by multimodal analysis, and feature genes closely associated with AR-induced VHD were obtained by time series analysis in conjunction with weighted gene co-expression network analysis. The results may provide comprehensive insights into the mechanistic study and potential therapeutic targets of AR-induced VHD.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 10","pages":"Article 101324"},"PeriodicalIF":8.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acellular Tissue Engineered Vessels as Coronary Artery Bypass Grafts","authors":"Adam R. Williams MD ,&nbsp;Kevin M. Nash PhD, DABT ,&nbsp;Robert D. Kirkton PhD ,&nbsp;Garyn S. Levitan BS ,&nbsp;Melissa A. Daubert MD ,&nbsp;Susan A. Whitney MBA, BSRT(R)(N)(CT) ,&nbsp;Kaleb M. Naegeli PhD ,&nbsp;Abigail R. Benkert MD ,&nbsp;Sharon L. McCartney MD ,&nbsp;Heather L. Prichard PhD ,&nbsp;Laura E. Niklason MD, PhD ,&nbsp;Alan P. Kypson MD","doi":"10.1016/j.jacbts.2025.101379","DOIUrl":"10.1016/j.jacbts.2025.101379","url":null,"abstract":"<div><div>Coronary artery bypass graft (CABG) uses the patient’s internal mammary artery and saphenous vein; however, unavailable or poor quality autologous vessels limit revascularization. This study addresses the critical need for alternative CABG conduits by evaluating a small diameter acellular tissue-engineered vessel ([sdATEV], 3.5 mm) in a primate model. Adult baboons (n = 5) underwent CABG to the right coronary artery (RCA) with an sdATEV. Patency, diameter, and cardiac function were longitudinally assessed by computed tomography angiography. All sdATEVs remained patent throughout the 6-month study. Computed tomography angiography demonstrated that the distal sdATEV diameter gradually remodeled to approximate the smaller baboon RCA. Histology and spatial transcriptomics revealed that sdATEVs recellularized with host endothelial and smooth muscle cells including a quiescent neomedia layer with gene expression patterns similar to the RCA, indicating that host cell ingrowth from the bypassed coronary artery regulates sdATEV diameter. These results suggest that the sdATEV is a durable alternative CABG conduit.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 10","pages":"Article 101379"},"PeriodicalIF":8.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy","authors":"Reo Hata MD ,&nbsp;Shunsuke Funakoshi MD, PhD ,&nbsp;Takeru Makiyama MD, PhD ,&nbsp;Takao Kato MD, PhD ,&nbsp;Megumi Narita BS ,&nbsp;Yasuko Matsumura MS ,&nbsp;Ryoko Hirohata MS ,&nbsp;Yuki Naka BS ,&nbsp;Kazumi Ida MS ,&nbsp;Hiroaki Ito MD ,&nbsp;Akihiko Yoshizawa MD, PhD ,&nbsp;Yasuhito Nannya MD, PhD ,&nbsp;Hironori Haga MD, PhD ,&nbsp;Seishi Ogawa MD, PhD ,&nbsp;Koh Ono MD, PhD ,&nbsp;Takeshi Kimura MD, PhD ,&nbsp;Yoshinori Yoshida MD, PhD","doi":"10.1016/j.jacbts.2025.101363","DOIUrl":"10.1016/j.jacbts.2025.101363","url":null,"abstract":"<div><div>Cardiac fibrosis drives dysfunction in dilated cardiomyopathy (DCM); yet, effective therapies are limited. This study identifies FGFR1 as a critical target in cardiac fibrosis using transcriptomic and histological analyses of 58 human DCM biopsies. <em>FGFR1</em> expression correlated with fibrosis severity, and inhibition by AZD4547 reduced fibrosis and improved cardiac function in organoid and murine models. These findings validate FGFR1 inhibition as a promising therapeutic strategy for mitigating fibrosis and improving outcomes in heart failure associated with DCM.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 10","pages":"Article 101363"},"PeriodicalIF":8.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small Interfering RNA Therapy Targeting the Long Noncoding RNA SMILR for Therapeutic Intervention in Coronary Artery Bypass Graft Failure.","authors":"Simon D Brown, Anna L Malinowska, Matthew Bennett, Andrés F Correa-Sánchez, Laia Linda Horcasitas Valencia, Aimee P Lucignoli, Anna K Barton, Laura Clark, Judith C Sluimer, Scott P Webster, Julie Rodor, David E Newby, Mark Cunningham, Andrew H Baker","doi":"10.1016/j.jacbts.2025.101364","DOIUrl":"https://doi.org/10.1016/j.jacbts.2025.101364","url":null,"abstract":"<p><p>Coronary artery bypass graft (CABG) surgery remains the gold standard of care to prevent myocardial ischemia in patients with advanced atherosclerosis; however, poor long-term graft patency remains a considerable and long-standing problem. Excessive vascular smooth muscle cell (SMC) proliferation in the grafted tissue is recognized as central to late CABG failure. We previously identified SMILR, a human-specific SMC-enriched long noncoding RNA that drives SMC proliferation, suggesting that targeting SMILR expression could be a novel way to prevent neointima formation, and thus CABG failure. Here, we sought to identify a lead siRNA for clinical development. We describe the design and synthesis of a library of 76 chemically enhanced SMILR-targeting siRNA. From this library, we identify a lead siRNA, BHF7, which demonstrates potent and reproducible silencing of SMILR expression, and which robustly blocks vascular smooth muscle cell proliferation, both in vitro and in the ex vivo human saphenous vein model. We further demonstrate using RNA-sequencing that BHF7 down-regulates the expression of genes associated with proliferation and does not induce the expression of interferon or apoptosis genes, suggesting it has a favorable safety profile, both on- and off-target. Finally, we performed TUNEL staining on BHF7-treated tissues and measured the levels of cleaved caspase-3 by enzyme-linked immunosorbent assay after BHF7 treatment. This demonstrated that BHF7 does not induce a cytotoxic response either in vitro or ex vivo. Collectively, these data represent a preclinical package into the function and specificity of BHF7 which warrants further investigation into the possibility of utilizing BHF7 as a novel, ex vivo RNA therapeutic for the prevention of CABG failure in humans.</p>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":" ","pages":"101364"},"PeriodicalIF":8.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering Developmental Origins of Aortic Valve Disease","authors":"Deepak Srivastava","doi":"10.1016/j.jacbts.2025.101372","DOIUrl":"10.1016/j.jacbts.2025.101372","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 9","pages":"Article 101372"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full issue PDF","authors":"","doi":"10.1016/S2452-302X(25)00340-7","DOIUrl":"10.1016/S2452-302X(25)00340-7","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 9","pages":"Article 101387"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On Macrophage Culture","authors":"Nina Kumowski MD ,&nbsp;Matthias Nahrendorf MD, PhD (Editor-in-Chief, JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2025.101375","DOIUrl":"10.1016/j.jacbts.2025.101375","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 9","pages":"Article 101375"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freeze-Dried Platelet-Derived Hemostatic Products to Treat Bleeding in Dual Antiplatelet Therapy","authors":"Laura M. Dionisio ,&nbsp;Jose A. Cancelas","doi":"10.1016/j.jacbts.2025.101374","DOIUrl":"10.1016/j.jacbts.2025.101374","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 9","pages":"Article 101374"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}