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In Memory of Dr Gary D. Lopaschuk, PhD (1955-2025). 纪念Gary D. Lopaschuk博士（1955-2025）。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-04-28 DOI: 10.1016/j.jacbts.2025.04.001
Jason R B Dyck
{"title":"In Memory of Dr Gary D. Lopaschuk, PhD (1955-2025).","authors":"Jason R B Dyck","doi":"10.1016/j.jacbts.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.jacbts.2025.04.001","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SLAMF7 Restrains Pro-Inflammatory Macrophage Activation to Counteract Doxorubicin-Induced Cardiotoxicity. SLAMF7抑制促炎巨噬细胞活化以对抗阿霉素诱导的心脏毒性。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-04-16 DOI: 10.1016/j.jacbts.2025.02.015
Ao Liu, Peiyuan Bai, Hongmin You, Zehao Zhuang, Fangyan Tian, Haobo Weng, Xuemei Wei, Lu Tang, Litao Wang, Chaobao Liu, Jinghong Zhang, Minmin Sun, Shuning Zhang, Xianhong Shu, Junbo Ge
{"title":"SLAMF7 Restrains Pro-Inflammatory Macrophage Activation to Counteract Doxorubicin-Induced Cardiotoxicity.","authors":"Ao Liu, Peiyuan Bai, Hongmin You, Zehao Zhuang, Fangyan Tian, Haobo Weng, Xuemei Wei, Lu Tang, Litao Wang, Chaobao Liu, Jinghong Zhang, Minmin Sun, Shuning Zhang, Xianhong Shu, Junbo Ge","doi":"10.1016/j.jacbts.2025.02.015","DOIUrl":"https://doi.org/10.1016/j.jacbts.2025.02.015","url":null,"abstract":"<p><p>Doxorubicin-induced cardiotoxicity (DIC) poses a significant challenge in cancer treatment. This study investigated the role of SLAMF7 in DIC, particularly in macrophage-mediated inflammation. Using SLAMF7 knockout mice, we found that SLAMF7 deficiency exacerbates DIC and amplifies inflammatory responses. Mechanistically, SLAMF7 interacts with TNF receptor-associated factor 6 to attenuate nuclear factor κB signaling, reducing oxidative stress and proinflammatory cytokines. Notably, administering recombinant SLAMF7 protein effectively mitigated DIC. These findings underscore the critical role of SLAMF7 in protecting against DIC, positioning it as a promising therapeutic target.</p>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis. ATTR淀粉样变患者心肌因纤维化增加而产生的力较小。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-04-07 DOI: 10.1016/j.jacbts.2025.03.003
Gregory N Milburn, Jania Bell, Austin G Wellette-Hunsucker, Hollings Ruml, Andrew T Yackzan, Kenneth S Campbell
{"title":"Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis.","authors":"Gregory N Milburn, Jania Bell, Austin G Wellette-Hunsucker, Hollings Ruml, Andrew T Yackzan, Kenneth S Campbell","doi":"10.1016/j.jacbts.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.jacbts.2025.03.003","url":null,"abstract":"<p><p>Amyloid transthyretin cardiac amyloidosis is one of the most common infiltrative cardiomyopathies. Contractile, biochemical, and histological assays were performed on myocardium from patients with and without amyloid transthyretin amyloidosis. Force was reduced in amyloidosis, but calcium sensitivity was increased. The change in calcium sensitivity may reflect dephosphorylation of troponin I. The proportion of stiffness attributable to the extracellular matrix was larger in amyloidosis. Septal fibrosis and amyloid burden correlated with measurements from LV samples. Technetium pyrophosphate scans may detect increased microcalcifications in amyloidosis myocardium. Replacement of myocytes with extracellular matrix is the most important factor depressing contractile force in amyloidosis myocardium.</p>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic Adaptations and Therapies in Cardiac Hypoxia: Mechanisms and Clinical Implications/ Potential Strategies. 心脏缺氧的代谢适应和治疗：机制和临床意义/潜在策略。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-04-02 DOI: 10.1016/j.jacbts.2024.12.008
Huili Li, Fei Xiao, Chenghui Zhou, Tao Zhu, Sheng Wang
{"title":"Metabolic Adaptations and Therapies in Cardiac Hypoxia: Mechanisms and Clinical Implications/ Potential Strategies.","authors":"Huili Li, Fei Xiao, Chenghui Zhou, Tao Zhu, Sheng Wang","doi":"10.1016/j.jacbts.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.jacbts.2024.12.008","url":null,"abstract":"<p><p>Cardiac hypoxia triggers a cascade of responses and functional changes in myocardial and non-myocardial cells, profoundly affecting cellular metabolism, oxygen-sensing mechanisms, and immune responses. Myocardial cells, being the primary cell type in cardiac tissue, undergo significant alterations in energy metabolism, including glycolysis, fatty acid metabolism, ketone body utilization, and branched-chain amino acid metabolism, to maintain cardiac function under hypoxic conditions. Non-myocardial cells, such as fibroblasts, endothelial cells, and immune cells, although fewer in number, play crucial roles in regulating cardiac homeostasis, maintaining structural integrity, and responding to injury. This review discusses the metabolic reprogramming of immune cells, particularly macrophages, during ischemia-reperfusion injury and explores various therapeutic strategies that modulate these metabolic pathways to protect the heart during hypoxia. Understanding these interactions provides valuable insights and potential therapeutic targets for heart disease treatment.</p>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Semaglutide on Cardiac Mass and Function Requires Further Investigation 西马鲁肽对心脏质量和功能的影响有待进一步研究
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-04-01 DOI: 10.1016/j.jacbts.2025.02.027
Qiang Xu MD , Yuqin Mao PhD , Xinyu Weng PhD , Li Shen MD , Junbo Ge MD
{"title":"The Impact of Semaglutide on Cardiac Mass and Function Requires Further Investigation","authors":"Qiang Xu MD ,&nbsp;Yuqin Mao PhD ,&nbsp;Xinyu Weng PhD ,&nbsp;Li Shen MD ,&nbsp;Junbo Ge MD","doi":"10.1016/j.jacbts.2025.02.027","DOIUrl":"10.1016/j.jacbts.2025.02.027","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 4","pages":"Pages 508-509"},"PeriodicalIF":8.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biliary Metaplasia and Macrophage Activation Define the Cellular Landscape of Cardiogenic Liver Disease 胆道化生和巨噬细胞活化决定心源性肝病的细胞景观
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-04-01 DOI: 10.1016/j.jacbts.2024.12.003
Arick C. Park MD, PhD , Christina F. Fu BS , Adeesh Parvathaneni BS , Bin Q. Yang MD , Mandy M. Chan BS , Kathleen Byrnes MD , Joel D. Schilling MD, PhD
{"title":"Biliary Metaplasia and Macrophage Activation Define the Cellular Landscape of Cardiogenic Liver Disease","authors":"Arick C. Park MD, PhD ,&nbsp;Christina F. Fu BS ,&nbsp;Adeesh Parvathaneni BS ,&nbsp;Bin Q. Yang MD ,&nbsp;Mandy M. Chan BS ,&nbsp;Kathleen Byrnes MD ,&nbsp;Joel D. Schilling MD, PhD","doi":"10.1016/j.jacbts.2024.12.003","DOIUrl":"10.1016/j.jacbts.2024.12.003","url":null,"abstract":"<div><div>Right heart failure significantly impacts liver remodeling and function, a process referred to as cardiogenic liver disease. Although recognized as a risk factor for adverse outcomes, little is understood about the cellular and molecular players that contribute to liver disease in heart failure. Using human liver biopsy samples from patients with heart failure and a mouse model of liver congestion, we unraveled a nexus of macrophages, hepatic stellate cells, and biliary metaplastic cells that shape the pathologic environment of cardiogenic liver disease.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 4","pages":"Pages 434-454"},"PeriodicalIF":8.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Secondary Prevention Post-Myocardial Infarction With CSL112 CSL112促进心肌梗死后二级预防
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-04-01 DOI: 10.1016/j.jacbts.2025.01.015
Nathalie Pamir PhD , Rifat Eralp Ulusoy MD
{"title":"Advancing Secondary Prevention Post-Myocardial Infarction With CSL112","authors":"Nathalie Pamir PhD ,&nbsp;Rifat Eralp Ulusoy MD","doi":"10.1016/j.jacbts.2025.01.015","DOIUrl":"10.1016/j.jacbts.2025.01.015","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 4","pages":"Pages 419-421"},"PeriodicalIF":8.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JACC: Basic to Translational Science 2024 Thomas Force Young Investigator Award Winner JACC：基础到转化科学2024年Thomas Force青年研究者奖得主
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-04-01 DOI: 10.1016/j.jacbts.2025.01.021
Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)
{"title":"JACC: Basic to Translational Science 2024 Thomas Force Young Investigator Award Winner","authors":"Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2025.01.021","DOIUrl":"10.1016/j.jacbts.2025.01.021","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 4","pages":"Pages 547-548"},"PeriodicalIF":8.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apolipoprotein A1 (CSL112) Increases Lecithin-Cholesterol Acyltransferase Levels in HDL Particles and Promotes Reverse Cholesterol Transport 载脂蛋白A1 （CSL112）增加高密度脂蛋白颗粒中卵磷脂-胆固醇酰基转移酶水平并促进胆固醇逆向转运
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-04-01 DOI: 10.1016/j.jacbts.2024.11.001
Rommel A. Mathias PhD , Elena Velkoska PhD , Svetlana A. Didichenko PhD , Brandon H. Greene PhD , Xiahui Tan PhD , Alexey V. Navdaev PhD , Heidi L. Collins PhD , Steven J. Adelman PhD , Kyal Young BSc , Andreas Gille MD, PhD , Danielle Duffy MD , C. Michael Gibson MSc, MD , Matthias Pelzing PhD , Bronwyn A. Kingwell PhD
{"title":"Apolipoprotein A1 (CSL112) Increases Lecithin-Cholesterol Acyltransferase Levels in HDL Particles and Promotes Reverse Cholesterol Transport","authors":"Rommel A. Mathias PhD ,&nbsp;Elena Velkoska PhD ,&nbsp;Svetlana A. Didichenko PhD ,&nbsp;Brandon H. Greene PhD ,&nbsp;Xiahui Tan PhD ,&nbsp;Alexey V. Navdaev PhD ,&nbsp;Heidi L. Collins PhD ,&nbsp;Steven J. Adelman PhD ,&nbsp;Kyal Young BSc ,&nbsp;Andreas Gille MD, PhD ,&nbsp;Danielle Duffy MD ,&nbsp;C. Michael Gibson MSc, MD ,&nbsp;Matthias Pelzing PhD ,&nbsp;Bronwyn A. Kingwell PhD","doi":"10.1016/j.jacbts.2024.11.001","DOIUrl":"10.1016/j.jacbts.2024.11.001","url":null,"abstract":"<div><div>Although high-density lipoprotein (HDL) cholesterol is inversely correlated with cardiovascular risk, an emerging paradigm is focused on increasing reverse cholesterol transport (RCT) and HDL function via apolipoprotein A1 (ApoA1). The objective of this study was to investigate the effect of ApoA1 (CSL112) infusion on HDL protein composition, cholesterol esterification rate (CER), and cholesterol efflux capacity (CEC) in patients treated after acute myocardial infarction. CSL112 reduced levels of apolipoproteins A2, B, C, and E and serum amyloids A1 and A4, whereas ApoA1, ApoM, and lecithin-cholesterol acyltransferase were significantly elevated. Increased CEC, plasma HDL cholesterol levels, CER, and CEC also were observed in CSL112-treated patients.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 4","pages":"Pages 405-418"},"PeriodicalIF":8.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Aging in Heart Failure With Preserved Ejection Fraction 年龄在保留射血分数的心力衰竭中的作用
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-04-01 DOI: 10.1016/j.jacbts.2025.02.006
Andrea Salzano MD, PhD , Antonio Cittadini MD
{"title":"The Role of Aging in Heart Failure With Preserved Ejection Fraction","authors":"Andrea Salzano MD, PhD ,&nbsp;Antonio Cittadini MD","doi":"10.1016/j.jacbts.2025.02.006","DOIUrl":"10.1016/j.jacbts.2025.02.006","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 4","pages":"Pages 498-501"},"PeriodicalIF":8.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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