JACC: Basic to Translational Science最新文献

Linking Physiology and Biology in Plaque Erosion 将斑块侵蚀中的生理学和生物学联系起来

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-11-01 DOI: 10.1016/j.jacbts.2024.07.012

Christos V. Bourantas MD, PhD , Ryo Torii MSc, PhD , Patrick W. Serruys MD, PhD

引用次数: 0

Full Issue PDF 全期 PDF

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-11-01 DOI: 10.1016/S2452-302X(24)00399-1

引用次数: 0

Deubiquitinase USP25 Alleviates Obesity-Induced Cardiac Remodeling and Dysfunction by Downregulating TAK1 and Reducing TAK1-Mediated Inflammation 去泛素化酶USP25通过下调TAK1和减少TAK1介导的炎症缓解肥胖诱导的心脏重塑和功能障碍

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-11-01 DOI: 10.1016/j.jacbts.2024.06.001

Bozhi Ye MD , Yanghao Chen MS , Xudong Chen MS , Diyun Xu BA , Yucheng Jiang BA , Wante Lin BA , Danhong Fang MS , Jiachen Xu BA , Jibo Han MS , Xue Han MS , Xiaohong Long MS , Wei Wang BA , Hao Zhou MD , Gaojun Wu MD , Guang Liang PhD

{"title":"Deubiquitinase USP25 Alleviates Obesity-Induced Cardiac Remodeling and Dysfunction by Downregulating TAK1 and Reducing TAK1-Mediated Inflammation","authors":"Bozhi Ye MD , Yanghao Chen MS , Xudong Chen MS , Diyun Xu BA , Yucheng Jiang BA , Wante Lin BA , Danhong Fang MS , Jiachen Xu BA , Jibo Han MS , Xue Han MS , Xiaohong Long MS , Wei Wang BA , Hao Zhou MD , Gaojun Wu MD , Guang Liang PhD","doi":"10.1016/j.jacbts.2024.06.001","DOIUrl":"10.1016/j.jacbts.2024.06.001","url":null,"abstract":"<div><div>Deubiquitinating enzymes play a vital role in cardiovascular diseases. This study found that cardiomyocyte ubiquitin-specific protease 25 (USP25) expression was downregulated both in myocardial tissue of obesity cardiomyopathy and palmitic acid–stimulated cardiomyocytes. USP25 deficiency exacerbated high-fat diet–induced ventricular remodeling in mice, whereas overexpression of USP25 in cardiomyocytes reversed this pathological phenotype. Mechanistically, USP25 directly binds to TAK1 and P62, and the 178-cysteine of USP25 removes the K63 ubiquitin chain from P62, which promotes the degradation of TAK1 through the autophagy-lysosome pathway, thereby ameliorating obesity-induced ventricular remodeling by reducing inflammation through the TAK1-MAPK pathway. This finding identifies USP25 as a potential therapeutic target for obesity cardiomyopathy.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 11","pages":"Pages 1287-1304"},"PeriodicalIF":8.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pericardial Fluid of Patients With Coronary Artery Disease Can Drive Fibrosis Via TGF-Beta Pathway 冠状动脉疾病患者的心包液能通过 TGF-Beta 通路促进纤维化

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-11-01 DOI: 10.1016/j.jacbts.2024.06.007

Ali Fatehi Hassanabad MD, MSc , Darrell D. Belke PhD , Paul M.K. Gordon PhD , Guoqi Teng MD, PhD , Jameson A. Dundas BSc , Anna N. Zarzycki BSc , Jeannine Turnbull BSc, MSc , Justin F. Deniset PhD , Paul W.M. Fedak MD, PhD

引用次数: 0

When Off-Target Is the Target 当脱靶就是目标时

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-11-01 DOI: 10.1016/j.jacbts.2024.09.012

Jonathan A. Kirk PhD

引用次数: 0

Targeting Soluble TGF-β Factors 靶向可溶性 TGF-β 因子

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-11-01 DOI: 10.1016/j.jacbts.2024.04.005

Clarissa Becher MSc , Marius Wits MSc , Frances S. de Man Prof , Gonzalo Sanchez-Duffhues PhD , Marie-Jose Goumans Prof

{"title":"Targeting Soluble TGF-β Factors","authors":"Clarissa Becher MSc , Marius Wits MSc , Frances S. de Man Prof , Gonzalo Sanchez-Duffhues PhD , Marie-Jose Goumans Prof","doi":"10.1016/j.jacbts.2024.04.005","DOIUrl":"10.1016/j.jacbts.2024.04.005","url":null,"abstract":"<div><div>Pulmonary arterial hypertension (PAH) is a rare progressive disease characterized by pulmonary artery vascular remodeling, increased vascular resistance, and subsequent right ventricular hypertrophy and right heart failure. It is triggered by disrupted transforming growth factor (TGF)-β signaling, including loss-of-function mutations in the bone morphogenetic protein (BMP) receptor 2. Emerging treatments aim to inhibit elevated TGF-β levels or enhance diminished endothelial BMP signaling. This review aims to summarize the role of the TGF-β superfamily in the pathobiology of PAH and recent discoveries highlighting altered expression of TGF-β–related soluble factors in PAH patients that can serve as potential biomarkers and drug targets. The discussion focuses on how these altered factors can guide treatment decisions and monitor therapeutic responses, facilitating personalized patient care through the integration of diagnostics and therapy, that is, precision medicine. This approach tailors treatment strategies to individual patients based on their unique disease characteristics.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 11","pages":"Pages 1360-1374"},"PeriodicalIF":8.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Cell-Autonomous Cardiomyocyte Regulation Complicates Gene Supplementation Therapy for Lmna-Associated Cardiac Defects in Mice 非细胞自主性心肌细胞调控使小鼠 Lmna 相关心脏缺陷的基因补充疗法变得复杂

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-11-01 DOI: 10.1016/j.jacbts.2024.06.004

Yueshen Sun MB , Congting Guo BS , Zhan Chen BS , Junsen Lin BS , Luzi Yang MM , Yueyang Zhang BS , Chenyang Wu BS , Dongyu Zhao PhD , Blake Jardin MS , William T. Pu MD , Mingming Zhao PhD , Erdan Dong MD , Xiaomin Hu PhD , Shuyang Zhang MD , Yuxuan Guo PhD

{"title":"Non-Cell-Autonomous Cardiomyocyte Regulation Complicates Gene Supplementation Therapy for Lmna-Associated Cardiac Defects in Mice","authors":"Yueshen Sun MB , Congting Guo BS , Zhan Chen BS , Junsen Lin BS , Luzi Yang MM , Yueyang Zhang BS , Chenyang Wu BS , Dongyu Zhao PhD , Blake Jardin MS , William T. Pu MD , Mingming Zhao PhD , Erdan Dong MD , Xiaomin Hu PhD , Shuyang Zhang MD , Yuxuan Guo PhD","doi":"10.1016/j.jacbts.2024.06.004","DOIUrl":"10.1016/j.jacbts.2024.06.004","url":null,"abstract":"<div><div>The truncating mutations of <em>LMNA</em> are the major causes of cardiomyopathy. Here we studied 3 mouse models that carry germline, cardiomyocyte-specific, or genetic mosaic <em>Lmna</em> truncating mutations. Whereas the germline mutant manifested cardiac maturation defects, cardiomyocyte-specific mutation triggered pathological hypertrophy. In genetic mosaic analysis, no morphological defects were observed. Three adeno-associated virus (AAV) vectors were applied to addback lamin-A in a ubiquitous, cardiomyocyte-specific, or cardiomyocyte-excluded manner. Strikingly, only ubiquitous and cardiomyocyte-excluded AAV vectors mitigated the cardiac defects. Therefore, <em>Lmna</em> regulates cardiac morphology and function via a non-cell-autonomous mechanism. Noncardiomyocytes are key targets in AAV lamin-A therapy for <em>Lmna</em>-associated cardiac defects.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 11","pages":"Pages 1308-1325"},"PeriodicalIF":8.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting USP25 in the Heart 瞄准心脏中的 USP25

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-11-01 DOI: 10.1016/j.jacbts.2024.08.001

Hanming Zhang PhD

引用次数: 0

Endothelial Shear Stress Metrics Associate With Proinflammatory Pathways at the Culprit Site of Coronary Erosion 内皮剪切应力指标与冠状动脉侵蚀罪魁祸首的促炎途径有关

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-11-01 DOI: 10.1016/j.jacbts.2024.07.008

Mona E. Ahmed MD, PhD , David M. Leistner MD , Diaa Hakim MD, PhD , Youssef Abdelwahed MD , Ahmet U. Coskun PhD , Charles Maynard PhD , Claudio Seppelt MD , Gregor Nelles MD , Denitsa Meteva MD , Nicholas V. Cefalo BS , Peter Libby MD , Ulf Landmesser MD , Peter H. Stone MD

{"title":"Endothelial Shear Stress Metrics Associate With Proinflammatory Pathways at the Culprit Site of Coronary Erosion","authors":"Mona E. Ahmed MD, PhD , David M. Leistner MD , Diaa Hakim MD, PhD , Youssef Abdelwahed MD , Ahmet U. Coskun PhD , Charles Maynard PhD , Claudio Seppelt MD , Gregor Nelles MD , Denitsa Meteva MD , Nicholas V. Cefalo BS , Peter Libby MD , Ulf Landmesser MD , Peter H. Stone MD","doi":"10.1016/j.jacbts.2024.07.008","DOIUrl":"10.1016/j.jacbts.2024.07.008","url":null,"abstract":"<div><div>Low endothelial shear stress (ESS) and associated adverse biomechanical features stimulate inflammation, contribute to atherogenesis, and predispose to coronary plaque disruption. The mechanistic links between adverse flow-related hemodynamics and inflammatory mediators implicated in plaque erosion, however, remain little explored. We investigated the relationship of high-risk ESS metrics to culprit lesion proinflammatory/proatherogenic cells and cytokines/chemokines implicated in coronary plaque erosion in patients with acute coronary syndromes. In eroded plaques, low ESS, high ESS gradient, and steepness of plaque topographical slope associated with increased numbers of local T cells and subsets (CD4<sup>+</sup>, CD8<sup>+</sup>, natural killer T cells) as well as inflammatory mediators (interleukin [IL]-6, macrophage inflammatory protein-1β, IL-1β, IL-2).</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 11","pages":"Pages 1269-1283"},"PeriodicalIF":8.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune Shielding of Human Heart Valves 人体心脏瓣膜的免疫屏蔽

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-11-01 DOI: 10.1016/j.jacbts.2024.07.003

Marijn C. Peters PhD , Arnaud Zaldumbide PhD , Esmee J. Groeneveld BSc , Martijn J.W.E. Rabelink BSc , Janneke H. Peerlings MSc , Antoon van den Bogaerdt MSc , Carlijn V.C. Bouten PhD , Rob C. Hoeben PhD , Marie-Jose Goumans PhD , Abraham van Wijk MD, PhD

引用次数: 0