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Exercise Therapy Rescues Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF 运动疗法可拯救心脏代谢性HFpEF的骨骼肌功能障碍和运动不耐受。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-12-01 DOI: 10.1016/j.jacbts.2024.07.009
Heather Quiriarte MS , Robert C. Noland PhD , James E. Stampley PhD , Gregory Davis MS , Zhen Li PhD , Eunhan Cho PhD , Youyoung Kim MS , Jake Doiron BS , Guillaume Spielmann PhD , Sujoy Ghosh PhD , Sanjiv J. Shah MD , Brian A. Irving PhD , David J. Lefer PhD , Timothy D. Allerton PhD
{"title":"Exercise Therapy Rescues Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF","authors":"Heather Quiriarte MS ,&nbsp;Robert C. Noland PhD ,&nbsp;James E. Stampley PhD ,&nbsp;Gregory Davis MS ,&nbsp;Zhen Li PhD ,&nbsp;Eunhan Cho PhD ,&nbsp;Youyoung Kim MS ,&nbsp;Jake Doiron BS ,&nbsp;Guillaume Spielmann PhD ,&nbsp;Sujoy Ghosh PhD ,&nbsp;Sanjiv J. Shah MD ,&nbsp;Brian A. Irving PhD ,&nbsp;David J. Lefer PhD ,&nbsp;Timothy D. Allerton PhD","doi":"10.1016/j.jacbts.2024.07.009","DOIUrl":"10.1016/j.jacbts.2024.07.009","url":null,"abstract":"<div><div>Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related to skeletal muscle metabolism. In a “2-hit” model of HFpEF, we investigated the ability of exercise therapy (voluntary wheel running) to reverse skeletal muscle dysfunction and exercise intolerance. Using state-of-the-art metabolic cages and a multiomic approach, we demonstrate exercise can rescue dysfunctional skeletal muscle lipid and branched-chain amino acid oxidation and restore exercise capacity in mice with cardiometabolic HFpEF. These results underscore the importance of skeletal muscle metabolism to improve exercise intolerance in HFpEF.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 12","pages":"Pages 1409-1425"},"PeriodicalIF":8.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Full Issue PDF 完整版PDF
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-12-01 DOI: 10.1016/S2452-302X(24)00429-7
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引用次数: 0
Real-Time Revolution 实时革命：自适应TMVR解决方案。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-12-01 DOI: 10.1016/j.jacbts.2024.09.013
Shira Burg DVM, PhD, Yulia Cladco MD
{"title":"Real-Time Revolution","authors":"Shira Burg DVM, PhD,&nbsp;Yulia Cladco MD","doi":"10.1016/j.jacbts.2024.09.013","DOIUrl":"10.1016/j.jacbts.2024.09.013","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 12","pages":"Pages 1379-1381"},"PeriodicalIF":8.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TriClover 三尖瓣：经导管修复三尖瓣的新技术，高效、适应症广。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-12-01 DOI: 10.1016/j.jacbts.2024.10.003
Michele De Bonis MD , Maurizio Taramasso MD, PhD , Marco Gard MA , Ottavio R. Alfieri MD
{"title":"TriClover","authors":"Michele De Bonis MD ,&nbsp;Maurizio Taramasso MD, PhD ,&nbsp;Marco Gard MA ,&nbsp;Ottavio R. Alfieri MD","doi":"10.1016/j.jacbts.2024.10.003","DOIUrl":"10.1016/j.jacbts.2024.10.003","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 12","pages":"Pages 1382-1384"},"PeriodicalIF":8.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing the 2024 Transcatheter Cardiovascular Therapeutics (TCT) Shark Tank Presentations 介绍2024年经导管心血管治疗（TCT） Shark Tank演讲。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-12-01 DOI: 10.1016/j.jacbts.2024.11.002
Douglas L. Mann MD (Editor-in-Chief, JACC: Basic to Translational Science)
{"title":"Introducing the 2024 Transcatheter Cardiovascular Therapeutics (TCT) Shark Tank Presentations","authors":"Douglas L. Mann MD (Editor-in-Chief, JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2024.11.002","DOIUrl":"10.1016/j.jacbts.2024.11.002","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 12","pages":"Pages 1377-1378"},"PeriodicalIF":8.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowing Your ABCs 了解你的abc：巨噬细胞abca1介导的胆固醇外排作为动脉粥样硬化性心血管疾病的治疗靶点
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-12-01 DOI: 10.1016/j.jacbts.2024.09.008
George A. Karpouzas MD , Nicoletta Ronda MD, PhD
{"title":"Knowing Your ABCs","authors":"George A. Karpouzas MD ,&nbsp;Nicoletta Ronda MD, PhD","doi":"10.1016/j.jacbts.2024.09.008","DOIUrl":"10.1016/j.jacbts.2024.09.008","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 12","pages":"Pages 1406-1408"},"PeriodicalIF":8.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ABCA1-Super Enhancer RNA Promotes Cholesterol Efflux, Reduces Macrophage-Mediated Inflammation and Atherosclerosis abca1 -超级增强子RNA促进胆固醇外流，减少巨噬细胞介导的炎症和动脉粥样硬化。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-12-01 DOI: 10.1016/j.jacbts.2024.08.005
Jing Wang PhD , Qianqian Xiao MD , Yuwei Cai MD , Man Wang MD , Chen Chen MD , Luyun Wang MD, PhD , Ruiying Ma MD , Yanyan Cao PhD , Yan Wang MD, PhD , Hu Ding MD, PhD , Dao Wen Wang MD, PhD
{"title":"ABCA1-Super Enhancer RNA Promotes Cholesterol Efflux, Reduces Macrophage-Mediated Inflammation and Atherosclerosis","authors":"Jing Wang PhD ,&nbsp;Qianqian Xiao MD ,&nbsp;Yuwei Cai MD ,&nbsp;Man Wang MD ,&nbsp;Chen Chen MD ,&nbsp;Luyun Wang MD, PhD ,&nbsp;Ruiying Ma MD ,&nbsp;Yanyan Cao PhD ,&nbsp;Yan Wang MD, PhD ,&nbsp;Hu Ding MD, PhD ,&nbsp;Dao Wen Wang MD, PhD","doi":"10.1016/j.jacbts.2024.08.005","DOIUrl":"10.1016/j.jacbts.2024.08.005","url":null,"abstract":"<div><div>We describe a previously uncharacterized ATP-binding cassette A1 super enhancer RNA (ABCA1-seRNA)-mediated cholesterol efflux. In addition, it promoted macrophage inflammatory cytokine release, and was causally correlated with coronary artery disease severity. Mechanistically, ABCA1-seRNA upregulated cholesterol efflux by interacting with mediator complex subunit 23 and recruiting retinoid X receptor-alpha and liver X receptor-alpha to promote ABCA1 transcription in a <em>cis</em> manner. Meanwhile, ABCA1-seRNA induced P65 ubiquitination degradation, and thereby repressed the macrophage inflammatory response. Consistently, overexpression of ABCA1-seRNA in ApoE<sup>−/−</sup> mice decreased plasma lipids, cytokines, and atherosclerotic plaques. These findings indicate ABCA1-seRNA is a critical epigenetic regulator that maintains cholesterol homeostasis and modulates inflammation, thus promising a therapeutic target for atherosclerotic cardiovascular diseases.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 12","pages":"Pages 1388-1405"},"PeriodicalIF":8.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophages Contribute to Cardiac Fibrosis and Diastolic Dysfunction in Systemic Sclerosis 巨噬细胞参与系统性硬化症的心脏纤维化和舒张功能障碍。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-12-01 DOI: 10.1016/j.jacbts.2024.08.008
Xaviar M. Jones MD , Russell G. Rogers PhD , Kara Tsi BS , Thassio Mesquita PhD , Alberto Marchevsky MD , Alessandra Ciullo PhD , Salwa Soussi PhD , Nunzio Bottini MD, PhD , Francesco Boin MD , Ahmed G.E. Ibrahim PhD, MPH , Eduardo Marbán MD, PhD
{"title":"Macrophages Contribute to Cardiac Fibrosis and Diastolic Dysfunction in Systemic Sclerosis","authors":"Xaviar M. Jones MD ,&nbsp;Russell G. Rogers PhD ,&nbsp;Kara Tsi BS ,&nbsp;Thassio Mesquita PhD ,&nbsp;Alberto Marchevsky MD ,&nbsp;Alessandra Ciullo PhD ,&nbsp;Salwa Soussi PhD ,&nbsp;Nunzio Bottini MD, PhD ,&nbsp;Francesco Boin MD ,&nbsp;Ahmed G.E. Ibrahim PhD, MPH ,&nbsp;Eduardo Marbán MD, PhD","doi":"10.1016/j.jacbts.2024.08.008","DOIUrl":"10.1016/j.jacbts.2024.08.008","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 12","pages":"Pages 1432-1434"},"PeriodicalIF":8.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of Skeletal Muscle Dysfunction in Cardiometabolic HFpEF and Its Reversal With Exercise Training 心脏代谢性HFpEF骨骼肌功能障碍的机制及其与运动训练的逆转。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-12-01 DOI: 10.1016/j.jacbts.2024.10.009
Bharathi Upadhya MD , Dalane W. Kitzman MD
{"title":"Mechanisms of Skeletal Muscle Dysfunction in Cardiometabolic HFpEF and Its Reversal With Exercise Training","authors":"Bharathi Upadhya MD ,&nbsp;Dalane W. Kitzman MD","doi":"10.1016/j.jacbts.2024.10.009","DOIUrl":"10.1016/j.jacbts.2024.10.009","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 12","pages":"Pages 1426-1428"},"PeriodicalIF":8.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revitalizing Innovation 振兴创新：解决心血管设备风险投资低迷的影响。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-12-01 DOI: 10.1016/j.jacbts.2024.08.006
Partha Sardar MD , Juan F. Granada MD , Louis A. Cannon MD
{"title":"Revitalizing Innovation","authors":"Partha Sardar MD ,&nbsp;Juan F. Granada MD ,&nbsp;Louis A. Cannon MD","doi":"10.1016/j.jacbts.2024.08.006","DOIUrl":"10.1016/j.jacbts.2024.08.006","url":null,"abstract":"<div><div>Venture capital (VC) plays a critical role in driving advancements in medical device innovations through its investment in early-stage companies. However, a concerning trend has emerged over the past decade: a decline in interest from VC funds toward investing in medical devices. Particularly alarming is the more than 50% decrease in investment in early-stage medical device development over the span of 2 decades. In the last 2 years, there has been a significant drop in small to mid-cap VC funds allocated toward the cardiovascular (CV) device space. These obstacles are exacerbated by several factors, including high interest rates, inflation, global economic slowdown, and ongoing international conflicts. These declining investments stifle innovation and jeopardize the timely development of life-saving technologies, highlighting the urgent need for increased funding support. This manuscript delves into the pivotal role of VC in CV device innovation and examines the challenges and concerns stemming from the downturn in VC financing within the CV device sector.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 12","pages":"Pages 1435-1439"},"PeriodicalIF":8.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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