JACC: Basic to Translational Science最新文献_第10页

Deep Image Segmentation for Cardiomyocyte Proliferation∗ 心肌细胞增殖的深度图像分割∗......

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2024.04.002

Md Abul Hassan Samee PhD , James F. Martin MD, PhD

引用次数: 0

RBM15 Protects From Myocardial Infarction by Stabilizing NAE1 RBM15 通过稳定 NAE1 防止心肌梗死

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2024.01.017

Hao Cheng MD, PhD , Jian Wu MD, PhD , Linnan Li MD, PhD , Xiaoyue Song MD, PhD , Junqiang Xue MD, PhD , Yuekai Shi MD, PhD , Yunzeng Zou MD, PhD , Jianying Ma MD, PhD , Junbo Ge MD, PhD

{"title":"RBM15 Protects From Myocardial Infarction by Stabilizing NAE1","authors":"Hao Cheng MD, PhD , Jian Wu MD, PhD , Linnan Li MD, PhD , Xiaoyue Song MD, PhD , Junqiang Xue MD, PhD , Yuekai Shi MD, PhD , Yunzeng Zou MD, PhD , Jianying Ma MD, PhD , Junbo Ge MD, PhD","doi":"10.1016/j.jacbts.2024.01.017","DOIUrl":"10.1016/j.jacbts.2024.01.017","url":null,"abstract":"<div><p>RNA-binding proteins play multiple roles in several biological processes. However, the roles of RBM15—an important RNA-binding protein and a significant regulator of RNA methylation—in cardiovascular diseases remain elusive. This study aimed to investigate the biological function of RBM15 and its fundamental mechanisms in myocardial infarction (MI). Methylated RNA immunoprecipitation sequencing was used to explore the N6-methyladenosine (m<sup>6</sup>A) difference between MI and normal tissues. Our findings showed the elevated level of m<sup>6</sup>A in MI, and its transcription profile in both MI and normal tissues. RBM15 was the main regulator and its overexpression attenuated apoptosis in cardiomyocytes and improved cardiac function in mice after MI. Then, we used one target NEDD8 activating enzyme E1 subunit and its inhibitor (MLN4924) to investigate the impact of RBM15 targets on cardiomyocytes. Finally, the enhanced m<sup>6</sup>A methylation in the presence of RBM15 overexpression led to the increased expression and stability of NEDD8 activating enzyme E1 subunit. Our findings suggest that the enhanced m<sup>6</sup>A level is a protective mechanism in MI, and RBM15 is significantly upregulated in MI and promotes cardiac function. This study showed that RBM15 affected MI by stabilizing its target on the cell apoptosis function, which might provide a new insight into MI therapy.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 5","pages":"Pages 631-648"},"PeriodicalIF":9.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24000469/pdfft?md5=a927496e84ee2a7355f7b36d7c06a981&pid=1-s2.0-S2452302X24000469-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140756421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stressing the Circle 强调圆

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2024.04.003

Simona Greco PhD, Fabio Martelli PhD

引用次数: 0

Dysregulation of IL-6/MCP-1/STAT3 Axis IL-6/MCP-1/STAT3 轴失调

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2024.03.006

Andreas Mitsis MD, MSc, PhD(c) , Stergios Tzikas MD, PhD , George Kassimis MD, PhD

引用次数: 0

Pulsatile ECMO 脉动 ECMO

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-04-01 DOI: 10.1016/j.jacbts.2024.02.015

Douglas E. Vincent BSME , Nader Moazami MD , David D’Alessandro MD , John F. Fraser MBChB, PhD , Silver Heinsar MD, PhD , Ellen T. Roche PhD , Brian C. Ayers MD , Manisha Singh PhD , Nina Langer MSME , Shriprasad R. Deshpande MBBS, MS , R.D.B. Jaquiss MD , Kiyotaka Fukamachi MD, PhD , Seyed Alireza Rabi MD, PhD , Asishana Osho MD, MPH , Taiyo Kuroda MD, PhD , Jamshid H. Karimov MD, PhD , Takuma Miyamoto MD, PhD , Palaniappan Sethu PhD , Guruprasad A. Giridharan PhD , Knut Kvernebo MD, PhD , Jack Copland MD

引用次数: 0

Do Not Lose Your Nerves 不要失去理智

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-04-01 DOI: 10.1016/j.jacbts.2024.02.005

Katrin Schäfer MD

引用次数: 0

JACC: Basic to Translational Science 2023 Thomas Force Young Investigator Award Winner JACC：基础到转化科学 2023 托马斯-费力青年研究员奖获得者

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-04-01 DOI: 10.1016/j.jacbts.2024.02.003

Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)

引用次数: 0

Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases 细胞衰老是心血管疾病的靶向风险因素：治疗意义JACC Family Series

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-04-01 DOI: 10.1016/j.jacbts.2023.12.003

Manish Kumar MD , Pengyi Yan PhD , George A. Kuchel MD , Ming Xu PhD

{"title":"Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases","authors":"Manish Kumar MD , Pengyi Yan PhD , George A. Kuchel MD , Ming Xu PhD","doi":"10.1016/j.jacbts.2023.12.003","DOIUrl":"10.1016/j.jacbts.2023.12.003","url":null,"abstract":"<div><p>The prevalence of cardiovascular diseases markedly rises with age. Cellular senescence, a hallmark of aging, is characterized by irreversible cell cycle arrest and the manifestation of a senescence-associated secretory phenotype, which has emerged as a significant contributor to aging, mortality, and a spectrum of chronic ailments. An increasing body of preclinical and clinical research has established connections between senescence, senescence-associated secretory phenotype, and age-related cardiac and vascular pathologies. This review comprehensively outlines studies delving into the detrimental impact of senescence on various cardiovascular diseases, encompassing systemic atherosclerosis (including coronary artery disease, stroke, and peripheral arterial disease), as well as conditions such as hypertension, congestive heart failure, arrhythmias, and valvular heart diseases. In addition, we have preclinical studies demonstrating the beneficial effects of senolytics—a class of drugs designed to eliminate senescent cells selectively across diverse cardiovascular disease scenarios. Finally, we address knowledge gaps on the influence of senescence on cardiovascular systems and discuss the future trajectory of strategies targeting senescence for cardiovascular diseases.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 4","pages":"Pages 522-534"},"PeriodicalIF":9.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X23005296/pdfft?md5=2d13297ee94e2c3226e4960e2d55ca1e&pid=1-s2.0-S2452302X23005296-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140609187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introducing the 2024 THT Shark Tank Edition of JACC: Basic to Translational Science 介绍《JACC.THT Shark Tank》2024 版：从基础科学到转化科学

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-04-01 DOI: 10.1016/j.jacbts.2024.03.002

Douglas L. Mann MD

引用次数: 0

Heart Failure Solutions 心力衰竭解决方案

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-04-01 DOI: 10.1016/j.jacbts.2024.02.010

Barry A. Borlaug MD , Mark Strong MBA, MSEE, BSEE

引用次数: 0