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IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-07-01 DOI: 10.1016/S2452-302X(24)00246-8
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引用次数: 0
The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure 改变舒张性心力衰竭的危险因素与补充 NAD+ 的疗效比较
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-06-01 DOI: 10.1016/j.jacbts.2024.01.011
Yen Chin Koay PhD , Ren Ping Liu BS , Bailey McIntosh BS , Niv Vigder BS , Serlin Lauren BS , Angela Yu Bai BS , Saki Tomita BS , Desmond Li PhD , Dylan Harney PhD , Benjamin Hunter PhD , Yunwei Zhang PhD , Jean Yang PhD , Paul Bannon MD, PhD , Ashleigh Philp PhD , Andrew Philp PhD , David M. Kaye MD, PhD , Mark Larance PhD , Sean Lal MD, PhD , John F. O’Sullivan MD, PhD
{"title":"The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure","authors":"Yen Chin Koay PhD ,&nbsp;Ren Ping Liu BS ,&nbsp;Bailey McIntosh BS ,&nbsp;Niv Vigder BS ,&nbsp;Serlin Lauren BS ,&nbsp;Angela Yu Bai BS ,&nbsp;Saki Tomita BS ,&nbsp;Desmond Li PhD ,&nbsp;Dylan Harney PhD ,&nbsp;Benjamin Hunter PhD ,&nbsp;Yunwei Zhang PhD ,&nbsp;Jean Yang PhD ,&nbsp;Paul Bannon MD, PhD ,&nbsp;Ashleigh Philp PhD ,&nbsp;Andrew Philp PhD ,&nbsp;David M. Kaye MD, PhD ,&nbsp;Mark Larance PhD ,&nbsp;Sean Lal MD, PhD ,&nbsp;John F. O’Sullivan MD, PhD","doi":"10.1016/j.jacbts.2024.01.011","DOIUrl":"10.1016/j.jacbts.2024.01.011","url":null,"abstract":"<div><p>Heart failure (HF) with left ventricular diastolic dysfunction is a growing global concern. This study evaluated myocardial oxidized nicotinamide adenine dinucleotide (NAD<sup>+</sup>) levels in human systolic and diastolic HF and in a murine model of HF with preserved ejection fraction, exploring NAD<sup>+</sup> repletion as therapy. We quantified myocardial NAD<sup>+</sup> and nicotinamide phosphoribosyltransferase levels, assessing restoration with nicotinamide riboside (NR). Findings show significant NAD<sup>+</sup> and nicotinamide phosphoribosyltransferase depletion in human diastolic HF myocardium, but NR successfully restored NAD<sup>+</sup> levels. In murine HF with preserved ejection fraction, NR as preventive and therapeutic intervention improved metabolic and antioxidant profiles. This study underscores NAD<sup>+</sup> repletion’s potential in diastolic HF management.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 6","pages":"Pages 733-750"},"PeriodicalIF":8.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24000391/pdfft?md5=8a81700691bd6593ea830e6408a07157&pid=1-s2.0-S2452302X24000391-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140314517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation 心肌梗死抑制蛋白质合成并导致转录和翻译脱钩
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-06-01 DOI: 10.1016/j.jacbts.2024.02.014
Shijie Liu PhD , Vaibhav Deshmukh PhD , Fangfei Wang MD , Jie Liang MS , Jenna Cusick BS , Xiao Li PhD , James F. Martin MD, PhD
{"title":"Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation","authors":"Shijie Liu PhD ,&nbsp;Vaibhav Deshmukh PhD ,&nbsp;Fangfei Wang MD ,&nbsp;Jie Liang MS ,&nbsp;Jenna Cusick BS ,&nbsp;Xiao Li PhD ,&nbsp;James F. Martin MD, PhD","doi":"10.1016/j.jacbts.2024.02.014","DOIUrl":"10.1016/j.jacbts.2024.02.014","url":null,"abstract":"<div><p>Gene expression involves transcription, translation, and mRNA and protein degradation. Advanced RNA sequencing measures mRNA levels for cell state assessment, but mRNA level does not fully reflect protein level. Identifying heart cell proteomes and their stress response is crucial. Using a cardiomyocyte-specific mouse model, we tracked protein synthesis after myocardial infarction. Our results showed that myocardial infarction suppresses protein synthesis and unveils a decoupling of translation and transcription regulation in cardiomyocytes.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 6","pages":"Pages 792-807"},"PeriodicalIF":8.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24000925/pdfft?md5=2c17b4343c499929c37abef57a0f3700&pid=1-s2.0-S2452302X24000925-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141040123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Antigen R, a Myofibroblast-Specific Target in Treating Cardiac Fibrosis∗ 治疗心脏纤维化的肌成纤维细胞特异性靶标--人类抗原 R∗
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-06-01 DOI: 10.1016/j.jacbts.2024.05.001
Abhay Srivastava MSc, PhD, Sanjiv Dhingra MSc, PhD
{"title":"Human Antigen R, a Myofibroblast-Specific Target in Treating Cardiac Fibrosis∗","authors":"Abhay Srivastava MSc, PhD,&nbsp;Sanjiv Dhingra MSc, PhD","doi":"10.1016/j.jacbts.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.jacbts.2024.05.001","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 6","pages":"Pages 771-773"},"PeriodicalIF":8.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24001864/pdfft?md5=d7729904889000f2d77ad8783b28fb40&pid=1-s2.0-S2452302X24001864-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress 纤维母细胞特异性清除人类抗原 R 可缓解心脏应激诱发的心肌纤维化
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-06-01 DOI: 10.1016/j.jacbts.2024.03.004
Mallikarjun Patil PhD , Sarojini Singh PhD , Praveen Kumar Dubey PhD , Sultan Tousif PhD , Prachi Umbarkar PhD , Qinkun Zhang MD , Hind Lal PhD , Mary Kathryn Sewell-Loftin PhD , Channakeshava Sokke Umeshappa PhD , Yohannes T. Ghebre PhD , Steven Pogwizd MD , Jianyi Zhang MD, PhD , Prasanna Krishnamurthy PhD
{"title":"Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress","authors":"Mallikarjun Patil PhD ,&nbsp;Sarojini Singh PhD ,&nbsp;Praveen Kumar Dubey PhD ,&nbsp;Sultan Tousif PhD ,&nbsp;Prachi Umbarkar PhD ,&nbsp;Qinkun Zhang MD ,&nbsp;Hind Lal PhD ,&nbsp;Mary Kathryn Sewell-Loftin PhD ,&nbsp;Channakeshava Sokke Umeshappa PhD ,&nbsp;Yohannes T. Ghebre PhD ,&nbsp;Steven Pogwizd MD ,&nbsp;Jianyi Zhang MD, PhD ,&nbsp;Prasanna Krishnamurthy PhD","doi":"10.1016/j.jacbts.2024.03.004","DOIUrl":"https://doi.org/10.1016/j.jacbts.2024.03.004","url":null,"abstract":"<div><p>Cardiac fibrosis can be mitigated by limiting fibroblast-to-myofibroblast differentiation and proliferation. Human antigen R (HuR) modulates messenger RNA stability and expression of multiple genes. However, the direct role of cardiac myofibroblast HuR is unknown. Myofibroblast-specific deletion of HuR limited cardiac fibrosis and preserved cardiac functions in pressure overload injury. Knockdown of HuR in transforming growth factor-β1–treated cardiac fibroblasts suppressed myofibroblast differentiation and proliferation. HuR deletion abrogated the expression and messenger RNA stability of cyclins D1 and A2, suggesting a potential mechanism by which HuR promotes myofibroblast proliferation. Overall, these data suggest that inhibition of HuR could be a potential therapeutic approach to limit cardiac fibrosis.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 6","pages":"Pages 754-770"},"PeriodicalIF":8.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24001001/pdfft?md5=1dfef1dc400593b49b939db150e6f189&pid=1-s2.0-S2452302X24001001-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Dual Paclitaxel and Sirolimus Nanoparticle-Coated Balloon 紫杉醇和西罗莫司纳米粒子双涂层球囊的有效性和安全性
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-06-01 DOI: 10.1016/j.jacbts.2024.02.002
Kenji Kawai MD , Mohammed Tanjimur Rahman PhD , Ryan Nowicki BS , Frank D. Kolodgie PhD , Atsushi Sakamoto MD , Rika Kawakami MD , Takao Konishi MD , Renu Virmani MD , Vinod Labhasetwar PhD , Aloke V. Finn MD
{"title":"Efficacy and Safety of Dual Paclitaxel and Sirolimus Nanoparticle-Coated Balloon","authors":"Kenji Kawai MD ,&nbsp;Mohammed Tanjimur Rahman PhD ,&nbsp;Ryan Nowicki BS ,&nbsp;Frank D. Kolodgie PhD ,&nbsp;Atsushi Sakamoto MD ,&nbsp;Rika Kawakami MD ,&nbsp;Takao Konishi MD ,&nbsp;Renu Virmani MD ,&nbsp;Vinod Labhasetwar PhD ,&nbsp;Aloke V. Finn MD","doi":"10.1016/j.jacbts.2024.02.002","DOIUrl":"10.1016/j.jacbts.2024.02.002","url":null,"abstract":"<div><p>We evaluated a novel dual active pharmaceutical ingredient (API) drug-coated balloon (DCB), which consists of a coating of nanoparticles encapsulating low-dose paclitaxel (PTX) in combination with sirolimus in a synergistic ratio. Compared to the PTX DCB, the dual API DCB demonstrated similar inhibition of cell proliferation in vitro but at a significantly lower total drug dose (over 13 times lower than sirolimus nanoparticles). Animal experiments demonstrated that the dual API DCB is more effective in inhibiting intimal cell proliferation with insignificant downstream embolic effects and myocardial damage compared to the PTX DCB. These findings indicate that dual API DCBs have a high potential to demonstrate improved clinical outcomes and a greater safety profile than the PTX DCBs.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 6","pages":"Pages 774-789"},"PeriodicalIF":8.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24000470/pdfft?md5=68744bf997c068d56667c0c3fb94f539&pid=1-s2.0-S2452302X24000470-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141038999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Mechanisms and Therapeutic Targeting of Ferroptosis in Doxorubicin-Induced Cardiotoxicity 多柔比星诱导的心脏毒性中铁蛋白沉积的分子机制和治疗靶点
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-06-01 DOI: 10.1016/j.jacbts.2023.10.009
Lin Wu MD , Yingmei Zhang MD, PhD , Guizhen Wang MD , Jun Ren MD, PhD
{"title":"Molecular Mechanisms and Therapeutic Targeting of Ferroptosis in Doxorubicin-Induced Cardiotoxicity","authors":"Lin Wu MD ,&nbsp;Yingmei Zhang MD, PhD ,&nbsp;Guizhen Wang MD ,&nbsp;Jun Ren MD, PhD","doi":"10.1016/j.jacbts.2023.10.009","DOIUrl":"10.1016/j.jacbts.2023.10.009","url":null,"abstract":"<div><p>Ferroptosis, an iron-dependent form of regulated cell death, has received increasing attention for its pathophysiologic contribution to the onset and development of doxorubicin-induced cardiotoxicity. Moreover, modulation of ferroptosis with specific inhibitors may provide new therapeutic opportunities for doxorubicin-induced cardiotoxicity. Here, we will review the molecular mechanisms and therapeutic promise of targeting ferroptosis in doxorubicin-induced cardiotoxicity.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 6","pages":"Pages 811-826"},"PeriodicalIF":8.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X23004928/pdfft?md5=0aa310d51e893a85525d977524e5c892&pid=1-s2.0-S2452302X23004928-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139095908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Turn(over) the Page 翻页
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-06-01 DOI: 10.1016/j.jacbts.2024.05.002
Thomas G. Martin PhD , Leslie A. Leinwand PhD
{"title":"Turn(over) the Page","authors":"Thomas G. Martin PhD ,&nbsp;Leslie A. Leinwand PhD","doi":"10.1016/j.jacbts.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.jacbts.2024.05.002","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 6","pages":"Pages 808-810"},"PeriodicalIF":8.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24001876/pdfft?md5=b89b3ec9289a3d23dbc1a23f3678e48a&pid=1-s2.0-S2452302X24001876-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remembering Ada L. Steininger 缅怀艾达-L-斯坦宁格
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-06-01 DOI: 10.1016/j.jacbts.2024.05.004
Douglas L. Mann MD (Editor-in-Chief, JACC: Basic to Translational Science)
{"title":"Remembering Ada L. Steininger","authors":"Douglas L. Mann MD (Editor-in-Chief, JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.jacbts.2024.05.004","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 6","pages":"Page 844"},"PeriodicalIF":8.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X2400189X/pdfft?md5=ebfd16973328dba6319e0a3cee6ff63c&pid=1-s2.0-S2452302X2400189X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coordinate Targeting of Mitochondrial Energetics, Antioxidant Defenses, and Inflammation 线粒体能量、抗氧化防御和炎症的协调目标
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-06-01 DOI: 10.1016/j.jacbts.2024.02.013
Michael N. Sack MD, PhD
{"title":"Coordinate Targeting of Mitochondrial Energetics, Antioxidant Defenses, and Inflammation","authors":"Michael N. Sack MD, PhD","doi":"10.1016/j.jacbts.2024.02.013","DOIUrl":"https://doi.org/10.1016/j.jacbts.2024.02.013","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 6","pages":"Pages 751-753"},"PeriodicalIF":8.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24000913/pdfft?md5=2435a024ae847b02f4d71c9a359b3743&pid=1-s2.0-S2452302X24000913-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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