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IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-03-01 Epub Date: 2026-03-23 DOI: 10.1016/S2452-302X(26)00041-0
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引用次数: 0
The Twisted Tale of Interleukin-18 in Atherosclerosis 白介素-18在动脉粥样硬化中的扭曲故事。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-03-01 Epub Date: 2026-02-25 DOI: 10.1016/j.jacbts.2026.101489
Peter Libby MD , Tetsushi Nakao MD, PhD
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引用次数: 0
T Cell Polarization in Heart Failure 心力衰竭中的T细胞极化
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-03-01 Epub Date: 2026-03-23 DOI: 10.1016/j.jacbts.2026.101507
Marinos Kallikourdis PhD
{"title":"T Cell Polarization in Heart Failure","authors":"Marinos Kallikourdis PhD","doi":"10.1016/j.jacbts.2026.101507","DOIUrl":"10.1016/j.jacbts.2026.101507","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 3","pages":"Article 101507"},"PeriodicalIF":8.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147539337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Full Issue PDF 完整版PDF
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-02-01 Epub Date: 2026-02-23 DOI: 10.1016/S2452-302X(26)00023-9
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引用次数: 0
Human Left Ventricle circRNA-miRNA-mRNA Network Analyses Reveal a Novel Proangiogenic Role for circNPHP1 Under Ischemic Conditions 人左心室circRNA-miRNA-mRNA网络分析揭示了缺血条件下circNPHP1的新促血管生成作用。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-02-01 Epub Date: 2026-01-20 DOI: 10.1016/j.jacbts.2025.101468
Maryam Anwar PhD , Moumita Sarkar PhD , Kerrie Ford PhD , Gianni D. Angelini MD , Prakash P. Punjabi MD, PhD , Yingshu Guan MSc , Abas Laftah PhD , Aránzazu Chamorro-Jorganes PhD , Jiahui Ji PhD , Prashant K. Srivastava PhD , Enrico Petretto PhD , Costanza Emanueli PhD
{"title":"Human Left Ventricle circRNA-miRNA-mRNA Network Analyses Reveal a Novel Proangiogenic Role for circNPHP1 Under Ischemic Conditions","authors":"Maryam Anwar PhD ,&nbsp;Moumita Sarkar PhD ,&nbsp;Kerrie Ford PhD ,&nbsp;Gianni D. Angelini MD ,&nbsp;Prakash P. Punjabi MD, PhD ,&nbsp;Yingshu Guan MSc ,&nbsp;Abas Laftah PhD ,&nbsp;Aránzazu Chamorro-Jorganes PhD ,&nbsp;Jiahui Ji PhD ,&nbsp;Prashant K. Srivastava PhD ,&nbsp;Enrico Petretto PhD ,&nbsp;Costanza Emanueli PhD","doi":"10.1016/j.jacbts.2025.101468","DOIUrl":"10.1016/j.jacbts.2025.101468","url":null,"abstract":"<div><div>Therapies promoting microvascular flow and endothelial repair require effective identification of new targets in ischemic heart disease (IHD). The aim of this study was to unravel and functionally investigate circular RNA (circRNA)-microRNA (miRNA)-messenger RNA (mRNA) networks in endothelial cells in the context of IHD and type 2 diabetes mellitus (T2DM). We performed RNA sequencing on left ventricle biopsies from patients with IHD, IHD and T2DM, and non-IHD. Next, we created circRNA-miRNA-mRNA networks and mechanistically investigated the top circRNA-miRNA sponging interactions in endothelial cells. We found that circNPHP1 promotes angiogenesis via sponging of miR-221-3p and regulates its downstream target genes, VEGFA and BCL2, in IHD and T2DM.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 2","pages":"Article 101468"},"PeriodicalIF":8.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protecting the Heart Against Anthracyclines 保护心脏免受蒽环类药物的侵害：对最佳心肌细胞模型的难以捉摸的探索。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-02-01 Epub Date: 2026-02-23 DOI: 10.1016/j.jacbts.2026.101490
Jose Max Narvaez-Paliza MD, Aarti Asnani MD
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引用次数: 0
Characterization of a New PRKG1 Mutation Associated With Thoracic Aortic Aneurysm and Dissection 与胸主动脉瘤和夹层相关的一种新的PRKG1突变的特征
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-02-01 Epub Date: 2026-02-23 DOI: 10.1016/j.jacbts.2026.101484
Darren E. Casteel PhD
{"title":"Characterization of a New PRKG1 Mutation Associated With Thoracic Aortic Aneurysm and Dissection","authors":"Darren E. Casteel PhD","doi":"10.1016/j.jacbts.2026.101484","DOIUrl":"10.1016/j.jacbts.2026.101484","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 2","pages":"Article 101484"},"PeriodicalIF":8.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognizing Early Career Translational Investigators 认识早期职业翻译研究者。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-02-01 Epub Date: 2026-02-23 DOI: 10.1016/j.jacbts.2026.101493
Matthias Nahrendorf MD (Editor-in-Chief: JACC: Basic to Translational Science)
{"title":"Recognizing Early Career Translational Investigators","authors":"Matthias Nahrendorf MD (Editor-in-Chief: JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2026.101493","DOIUrl":"10.1016/j.jacbts.2026.101493","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 2","pages":"Article 101493"},"PeriodicalIF":8.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibroblast RUNX1 Induces Maladaptive Post–Myocardial Infarction Remodeling 成纤维细胞RUNX1诱导心肌梗死后不适应重构
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-02-01 Epub Date: 2026-02-23 DOI: 10.1016/j.jacbts.2026.101487
Chang-Ru Tsai PhD , James F. Martin MD, PhD
{"title":"Fibroblast RUNX1 Induces Maladaptive Post–Myocardial Infarction Remodeling","authors":"Chang-Ru Tsai PhD ,&nbsp;James F. Martin MD, PhD","doi":"10.1016/j.jacbts.2026.101487","DOIUrl":"10.1016/j.jacbts.2026.101487","url":null,"abstract":"<div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (422KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (168KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 2","pages":"Article 101487"},"PeriodicalIF":8.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiopathogenic T Cells Govern Progression and Functional Remodeling in Inflammatory Cardiomyopathy and Chronic Myocarditis 心脏病T细胞控制炎症性心肌病和慢性心肌炎的进展和功能重塑。
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2026-02-01 Epub Date: 2026-01-12 DOI: 10.1016/j.jacbts.2025.101458
Anna Joachimbauer MD , Nadine Cadosch MSc , Cristina Gil-Cruz PhD , Christian Perez-Shibayama PhD , Kira Frischmann MSc , Emily Payne MD , Isabella Hanka MD , Micha T. Maeder MD, PhD , Hans Rickli MD , Felix C. Tanner MD , Frank Ruschitzka MD , Burkhard Ludewig DVM , Dörthe Schmidt MD, PhD
{"title":"Cardiopathogenic T Cells Govern Progression and Functional Remodeling in Inflammatory Cardiomyopathy and Chronic Myocarditis","authors":"Anna Joachimbauer MD ,&nbsp;Nadine Cadosch MSc ,&nbsp;Cristina Gil-Cruz PhD ,&nbsp;Christian Perez-Shibayama PhD ,&nbsp;Kira Frischmann MSc ,&nbsp;Emily Payne MD ,&nbsp;Isabella Hanka MD ,&nbsp;Micha T. Maeder MD, PhD ,&nbsp;Hans Rickli MD ,&nbsp;Felix C. Tanner MD ,&nbsp;Frank Ruschitzka MD ,&nbsp;Burkhard Ludewig DVM ,&nbsp;Dörthe Schmidt MD, PhD","doi":"10.1016/j.jacbts.2025.101458","DOIUrl":"10.1016/j.jacbts.2025.101458","url":null,"abstract":"<div><div>Echocardiographic imaging mirrors the immunopathological processes underlying the progression from acute myocarditis to inflammatory cardiomyopathy. T cell–mediated myocardial inflammation and edematous swelling in subepicardial regions at disease onset is followed by smoldering low-level myocardial inflammation or increasing cardiomyocyte loss and fibrotic remodeling. The resulting decline of cardiac function in the progressive disease is reflected and best predicted by impaired echocardiographic strain.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 2","pages":"Article 101458"},"PeriodicalIF":8.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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