JACC: Basic to Translational Science最新文献_第9页

Nitric Oxide Releasing Nanomaterials for Cardiovascular Applications 用于心血管应用的一氧化氮释放纳米材料

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2023.07.017

Tanveer A. Tabish PhD , Mark J. Crabtree PhD , Helen E. Townley PhD , Paul G. Winyard PhD , Craig A. Lygate PhD

{"title":"Nitric Oxide Releasing Nanomaterials for Cardiovascular Applications","authors":"Tanveer A. Tabish PhD , Mark J. Crabtree PhD , Helen E. Townley PhD , Paul G. Winyard PhD , Craig A. Lygate PhD","doi":"10.1016/j.jacbts.2023.07.017","DOIUrl":"10.1016/j.jacbts.2023.07.017","url":null,"abstract":"<div><p>A central paradigm of cardiovascular homeostasis is that impaired nitric oxide (NO) bioavailability results in a wide array of cardiovascular dysfunction including incompetent endothelium-dependent vasodilatation, thrombosis, vascular inflammation, and proliferation of the intima. Over the course of more than a century, NO donating formulations such as organic nitrates and nitrites have remained a cornerstone of treatment for patients with cardiovascular diseases. These donors primarily produce NO in the circulation and are not targeted to specific (sub)cellular sites of action. However, safe, and therapeutic levels of NO require delivery of the right amount to a precise location at the right time. To achieve these aims, several recent strategies aimed at therapeutically generating or releasing NO in living systems have shown that polymeric and inorganic (silica, gold) nanoparticles and nanoscale metal-organic frameworks could either generate NO endogenously by the catalytic decomposition of endogenous NO substrates or can store and release therapeutically relevant amounts of NO gas. NO-releasing nanomaterials have been developed for vascular implants (such as stents and grafts) to target atherosclerosis, hypertension, myocardial ischemia-reperfusion injury, and cardiac tissue engineering. In this review, we discuss the advances in design and development of novel NO-releasing nanomaterials for cardiovascular therapeutics and critically examine the therapeutic potential of these nanoplatforms to modulate cellular metabolism, to regulate vascular tone, inhibit platelet aggregation, and limit proliferation of vascular smooth muscle with minimal toxic effects.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 5","pages":"Pages 691-709"},"PeriodicalIF":9.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X23003315/pdfft?md5=dc3b7845445ec62e5e749327ff2dddd6&pid=1-s2.0-S2452302X23003315-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135848998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Life Cardiovascular Risk Factors and Midlife Epigenetic Aging 早年心血管风险因素与中年表观遗传衰老

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2024.02.006

Paul S. de Vries PhD , Anthony S. Zannas MD, PhD

引用次数: 0

More Bang for the Buck 物有所值

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2024.01.009

Timothy J. Kamp MD, PhD

引用次数: 0

Deep Learning Resolves Myovascular Dynamics in the Failing Human Heart 深度学习解析衰竭人体心脏的肌血管动态变化

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2024.02.007

Anish Karpurapu BS , Helen A. Williams BS , Paige DeBenedittis PhD , Caroline E. Baker BS , Simiao Ren PhD , Michael C. Thomas BS , Anneka J. Beard MS , Garth W. Devlin BS , Josephine Harrington MD , Lauren E. Parker BS , Abigail K. Smith , Boyla Mainsah PhD , Michelle Mendiola Pla MD , Aravind Asokan PhD , Dawn E. Bowles PhD , Edwin Iversen PhD , Leslie Collins PhD , Ravi Karra MD, MHS

{"title":"Deep Learning Resolves Myovascular Dynamics in the Failing Human Heart","authors":"Anish Karpurapu BS , Helen A. Williams BS , Paige DeBenedittis PhD , Caroline E. Baker BS , Simiao Ren PhD , Michael C. Thomas BS , Anneka J. Beard MS , Garth W. Devlin BS , Josephine Harrington MD , Lauren E. Parker BS , Abigail K. Smith , Boyla Mainsah PhD , Michelle Mendiola Pla MD , Aravind Asokan PhD , Dawn E. Bowles PhD , Edwin Iversen PhD , Leslie Collins PhD , Ravi Karra MD, MHS","doi":"10.1016/j.jacbts.2024.02.007","DOIUrl":"https://doi.org/10.1016/j.jacbts.2024.02.007","url":null,"abstract":"<div><p>The adult mammalian heart harbors minute levels of cycling cardiomyocytes (CMs). Large numbers of images are needed to accurately quantify cycling events using microscopy-based methods. CardioCount is a new deep learning–based pipeline to rigorously score nuclei in microscopic images. When applied to a repository of 368,434 human microscopic images, we found evidence of coupled growth between CMs and cardiac endothelial cells in the adult human heart. Additionally, we found that vascular rarefaction and CM hypertrophy are interrelated in end-stage heart failure. CardioCount is available for use via GitHub and via Google Colab for users with minimal machine learning experience.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 5","pages":"Pages 674-686"},"PeriodicalIF":9.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24000548/pdfft?md5=978db936761ec0f6df1d5fdff07202dc&pid=1-s2.0-S2452302X24000548-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141241292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase 脑梗塞后早期有害的抗炎巨噬细胞招募

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2024.01.019

Alexandre Paccalet PhD , Sally Badawi PhD , Bruno Pillot PhD , Lionel Augeul MRes , Laura Mechtouff MD, PhD , Zeina Harhous PhD , Yves Gouriou AP, PhD , Mélanie Paillard PhD , Marine Breuilly PhD , Camille Amaz MsRes , Yvonne Varillon MsRes , Simon Leboube MD , Camille Brun MsRes , Cyril Prieur MD, PhD , Gilles Rioufol MD, PhD , Nathan Mewton MD, PhD , Michel Ovize MD, PhD , Gabriel Bidaux PhD , Thomas Bochaton MD, PhD , Claire Crola Da Silva PhD

{"title":"Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase","authors":"Alexandre Paccalet PhD , Sally Badawi PhD , Bruno Pillot PhD , Lionel Augeul MRes , Laura Mechtouff MD, PhD , Zeina Harhous PhD , Yves Gouriou AP, PhD , Mélanie Paillard PhD , Marine Breuilly PhD , Camille Amaz MsRes , Yvonne Varillon MsRes , Simon Leboube MD , Camille Brun MsRes , Cyril Prieur MD, PhD , Gilles Rioufol MD, PhD , Nathan Mewton MD, PhD , Michel Ovize MD, PhD , Gabriel Bidaux PhD , Thomas Bochaton MD, PhD , Claire Crola Da Silva PhD","doi":"10.1016/j.jacbts.2024.01.019","DOIUrl":"10.1016/j.jacbts.2024.01.019","url":null,"abstract":"<div><p>Using a translational approach with an ST-segment myocardial infarction (STEMI) cohort and mouse model of myocardial infarction, we highlighted the role of the secreted IL-6 and MCP-1 cytokines and the STAT3 pathway in heart macrophage recruitment and activation. Cardiac myocytes secrete IL-6 and MCP-1 in response to hypoxic stress, leading to a recruitment and/or polarization of anti-inflammatory macrophages via the STAT3 pathway. In our preclinical model of myocardial infarction, neutralization of IL-6 and MCP-1 or STAT3 pathway reduced infarct size. Together, our data demonstrate that anti-inflammatory macrophages can be deleterious in the acute phase of STEMI.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 5","pages":"Pages 593-604"},"PeriodicalIF":9.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24000536/pdfft?md5=fea6bc8688d7a0ee7a08b3b71e733f77&pid=1-s2.0-S2452302X24000536-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140783885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thrombospondin-1 Drives Cardiac Remodeling in Chronic Kidney Disease 凝血酶原蛋白-1 推动慢性肾脏病的心脏重塑

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2024.01.010

Sohel M. Julovi MBBS, PhD , Katie Trinh BSc(Adv), MBBS , Harry Robertson BMedSc(Hons-I) , Cuicui Xu BSc, PhD , Nikita Minhas PhD , Seethalakshmi Viswanathan MBBS , Ellis Patrick BSc(Hons), PhD , John D. Horowitz MBBS, PhD , Daniel N. Meijles PhD , Natasha M. Rogers MBBS(Hons), PhD

{"title":"Thrombospondin-1 Drives Cardiac Remodeling in Chronic Kidney Disease","authors":"Sohel M. Julovi MBBS, PhD , Katie Trinh BSc(Adv), MBBS , Harry Robertson BMedSc(Hons-I) , Cuicui Xu BSc, PhD , Nikita Minhas PhD , Seethalakshmi Viswanathan MBBS , Ellis Patrick BSc(Hons), PhD , John D. Horowitz MBBS, PhD , Daniel N. Meijles PhD , Natasha M. Rogers MBBS(Hons), PhD","doi":"10.1016/j.jacbts.2024.01.010","DOIUrl":"10.1016/j.jacbts.2024.01.010","url":null,"abstract":"<div><p>Patients with chronic kidney disease (CKD) face a high risk of cardiovascular disease. Previous studies reported that endogenous thrombospondin 1 (TSP1) involves right ventricular remodeling and dysfunction. Here we show that a murine model of CKD increased myocardial TSP1 expression and produced left ventricular hypertrophy, fibrosis, and dysfunction. TSP1 knockout mice were protected from these features. In vitro, indoxyl sulfate is driving deleterious changes in cardiomyocyte through the TSP1. In patients with CKD, TSP1 and aryl hydrocarbon receptor were both differentially expressed in the myocardium. Our findings summon large clinical studies to confirm the translational role of TSP1 in patients with CKD.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 5","pages":"Pages 607-627"},"PeriodicalIF":9.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24000378/pdfft?md5=1bebe1fb29e4a8ad99df4bc1befd59eb&pid=1-s2.0-S2452302X24000378-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Clinical Imaging of Vascular Inflammation 血管炎症临床成像的进展：最新进展回顾

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2023.10.007

Henry W. West BMedSci, MBBS, PhD , Katerina Dangas BA , Charalambos Antoniades MD, PhD

{"title":"Advances in Clinical Imaging of Vascular Inflammation","authors":"Henry W. West BMedSci, MBBS, PhD , Katerina Dangas BA , Charalambos Antoniades MD, PhD","doi":"10.1016/j.jacbts.2023.10.007","DOIUrl":"10.1016/j.jacbts.2023.10.007","url":null,"abstract":"<div><p>Vascular inflammation is a major contributor to cardiovascular disease, particularly atherosclerotic disease, and early detection of vascular inflammation may be key to the ultimate reduction of residual cardiovascular morbidity and mortality. This review paper discusses the progress toward the clinical utility of noninvasive imaging techniques for assessing vascular inflammation, with a focus on coronary atherosclerosis. A discussion of multiple modalities is included: computed tomography (CT) imaging (the major focus of the review), cardiac magnetic resonance, ultrasound, and positron emission tomography imaging. The review covers recent progress in new technologies such as the novel CT biomarkers of coronary inflammation (eg, the perivascular fat attenuation index), new inflammation-specific tracers for positron emission tomography–CT imaging, and others. The strengths and limitations of each modality are explored, highlighting the potential for multi-modality imaging and the use of artificial intelligence image interpretation to improve both diagnostic and prognostic potential for common conditions such as coronary artery disease.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 5","pages":"Pages 710-732"},"PeriodicalIF":9.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X23004643/pdfft?md5=148dcf2964c24edaf141033b19dfd39e&pid=1-s2.0-S2452302X23004643-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138691496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of Epigenetic Therapy in Alleviating Cardiac Death and Fibrotic Remodeling in Myocardial Infarction∗ 表观遗传学疗法在缓解心肌梗死中的心脏死亡和纤维化重塑方面的潜力∗...

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2024.03.005

Olivier Morel MD, PhD

引用次数: 0

Full Issue PDF 全期 PDF

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/S2452-302X(24)00173-6

引用次数: 0

Shear-Sensitive circRNA-LONP2 Promotes Endothelial Inflammation and Atherosclerosis by Targeting NRF2/HO1 Signaling 剪切敏感性 circRNA-LONP2 通过靶向 NRF2/HO1 信号促进内皮炎症和动脉粥样硬化

IF 9.7 1区医学

JACC: Basic to Translational Science Pub Date : 2024-05-01 DOI: 10.1016/j.jacbts.2024.02.019

Ruoyu Wang MM , Yue Zeng MM , Ziqi Chen PhD , Dongwei Ma MM , Xiaozhe Zhang PhD , Guifu Wu MD, PhD , Wendong Fan PhD

{"title":"Shear-Sensitive circRNA-LONP2 Promotes Endothelial Inflammation and Atherosclerosis by Targeting NRF2/HO1 Signaling","authors":"Ruoyu Wang MM , Yue Zeng MM , Ziqi Chen PhD , Dongwei Ma MM , Xiaozhe Zhang PhD , Guifu Wu MD, PhD , Wendong Fan PhD","doi":"10.1016/j.jacbts.2024.02.019","DOIUrl":"https://doi.org/10.1016/j.jacbts.2024.02.019","url":null,"abstract":"<div><p>Hemodynamic shear stress is a frictional force that acts on vascular endothelial cells and is essential for endothelial homeostasis. Physiological laminar shear stress (LSS) suppresses endothelial inflammation and protects arteries from atherosclerosis. Herein, we screened differentially expressed circular RNAs (circRNAs) that were significantly altered in LSS-stimulated endothelial cells and found that circRNA-LONP2 was involved in modulating the flow-dependent inflammatory response. Furthermore, endothelial circRNA-LONP2 overexpression promoted endothelial inflammation and atherosclerosis in vitro and in vivo. Mechanistically, circRNA-LONP2 competitively sponged miR-200a-3p and subsequently promoted Kelch-like ECH-associated protein 1, Yes-associated protein 1, and enhancer of zeste homolog 2 expression, thereby inactivating nuclear factor erythroid 2–related factor 2/heme oxygenase-1 signaling, promoting oxidative stress and endothelial inflammation, and accelerating atherosclerosis. LSS-induced down-regulation of circRNA-LONP2 suppresses endothelial inflammation, at least in part, by activating the miR-200a-3p–mediated nuclear factor erythroid 2–related factor 2/heme oxygenase-1 signaling pathway. CircRNA-LONP2 may serve as a new therapeutic target for atherosclerosis.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 5","pages":"Pages 652-670"},"PeriodicalIF":9.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24001013/pdfft?md5=40566b453eaf52a13c53e7ce20a89fba&pid=1-s2.0-S2452302X24001013-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141241294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0