JACC: Basic to Translational Science最新文献_第9页

The Cardiohepatic Axis in Cirrhosis 肝硬化中的心肝轴

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-01 DOI: 10.1016/j.jacbts.2025.101314

Saad A. Ali DO, Kyle Frick MD

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引用次数: 0

FNDC4 Prevents Aging-Related Cardiac Dysfunction FNDC4通过恢复AMPKα/ ppar α依赖的线粒体功能来预防衰老相关的心功能障碍。

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-01 DOI: 10.1016/j.jacbts.2025.01.004

Xin Zhang MD , Wen-Sheng Dong MD , Kang Li BS , Yun-Jia Ye BS , Can Hu PhD

引用次数: 0

Ubiquitin Specific Protease 9X Regulates the Activation of ARK5 and Promotes Progression of Fibrotic Remodeling 泛素特异性蛋白酶9X调节ARK5的激活并促进纤维化重塑的进展。

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-01 DOI: 10.1016/j.jacbts.2025.02.014

Xuelian Li MM , Shijiu Jiang MD , Wenling Yang MM , Xianjie Zhu MM , Fan Zhang MM , Zhiyang Li MM , Xiaopeng Guo MD, PhD , Yumiao Wei MD, PhD

引用次数: 0

The Overlooked Organ 被忽视的器官

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-01 DOI: 10.1016/j.jacbts.2025.101335

Celeste Yin-Chieh Wu PhD, Yongfang Zhou MD, PhD, Tao Yuan BS, Srinivas Tipparaju PhD, Reggie Hui-Chao Lee PhD

引用次数: 0

ATP-Citrate Lyase in Heart Failure atp -柠檬酸分解酶在心力衰竭中的作用

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-01 DOI: 10.1016/j.jacbts.2025.101333

David Weissman MSc , Christoph Maack MD

引用次数: 0

The Cardiohepatic Axis in Metabolic Disease 代谢性疾病中的心肝轴

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-01 DOI: 10.1016/j.jacbts.2025.05.004

Andrew Hakeem MSc , Jop van Berlo MD, PhD , Xavier S. Revelo PhD

{"title":"The Cardiohepatic Axis in Metabolic Disease","authors":"Andrew Hakeem MSc , Jop van Berlo MD, PhD , Xavier S. Revelo PhD","doi":"10.1016/j.jacbts.2025.05.004","DOIUrl":"10.1016/j.jacbts.2025.05.004","url":null,"abstract":"<div><div>Heart and liver metabolic diseases often coexist because of local and systemic disorders that affect both organs via cardio-hepatic interactions. Here, we discuss the emerging evidence of organ crosstalk during cardiometabolic disease with an emphasis on the liver-to-heart axis. We highlight potential mechanisms by which metabolic dysfunction-associated steatotic liver disease contributes to cardiovascular complications. Metabolic dysfunction-associated steatotic liver disease, particularly its inflammatory entity, leads to the production of liver-derived secretory factors that regulate cardiac metabolism, inflammation, and remodeling. Thus, secreted hepatic factors represent an important mechanism of communication between the liver and heart during cardiometabolic disease. In addition to the direct crosstalk between organs, we argue that bone marrow reprogramming and clonal hematopoiesis of indeterminate potential are shared mechanisms of systemic inflammation that regulate the heart–liver axis during cardiometabolic disease. Thus, integrated cardiometabolic strategies hold a significant potential to bridge the gap between liver and cardiovascular health to improve patient outcomes.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 7","pages":"Article 101309"},"PeriodicalIF":8.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemokine Receptor 2 Is a Theranostic Biomarker for Abdominal Aortic Aneurysms 趋化因子受体2是腹主动脉瘤的治疗性生物标志物。

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-01 DOI: 10.1016/j.jacbts.2025.02.010

Santiago Elizondo-Benedetto MD , Sergio Sastriques-Dunlop MD , Lisa Detering MS , Batool Arif MS , Gyu Seong Heo PhD , Deborah Sultan BS , Hannah Luehmann MS , Xiaohui Zhang PhD , Xuefeng Gao PhD , Andrea Bredemeyer PhD , Mohamed S. Zaghloul MD , Kitty Harrison BS , Dakkota Thies BS , Laura McDonald BS , Christophe Combadière PhD , Chieh-Yu Lin MD, PhD , Yeona Kang PhD , Jie Zheng PhD , Joseph Ippolito MD, PhD , Richard Laforest PhD , Yongjian Liu PhD

{"title":"Chemokine Receptor 2 Is a Theranostic Biomarker for Abdominal Aortic Aneurysms","authors":"Santiago Elizondo-Benedetto MD , Sergio Sastriques-Dunlop MD , Lisa Detering MS , Batool Arif MS , Gyu Seong Heo PhD , Deborah Sultan BS , Hannah Luehmann MS , Xiaohui Zhang PhD , Xuefeng Gao PhD , Andrea Bredemeyer PhD , Mohamed S. Zaghloul MD , Kitty Harrison BS , Dakkota Thies BS , Laura McDonald BS , Christophe Combadière PhD , Chieh-Yu Lin MD, PhD , Yeona Kang PhD , Jie Zheng PhD , Joseph Ippolito MD, PhD , Richard Laforest PhD , Yongjian Liu PhD","doi":"10.1016/j.jacbts.2025.02.010","DOIUrl":"10.1016/j.jacbts.2025.02.010","url":null,"abstract":"<div><div>Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a high mortality upon rupture. There is no diagnosis to predict the rupture nor effective medical therapies to prevent rupture. Here we demonstrate that the C-C chemokine receptor type 2 (CCR2) is a theranostic biomarker for AAA. In rat AAA models, we determined the potential of a CCR2-targeted positron emission tomography radiotracer [<sup>64</sup>Cu]Cu-DOTA-ECL1i predicting AAA rupture. Using a CCR2 inhibitor, we observed the effective prevention of rupture in AAA rat models. In humans, CCR2 positron emission tomography showed intense radiotracer uptake along the AAA wall in patients while little signal was observed in healthy volunteers.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 7","pages":"Article 101250"},"PeriodicalIF":8.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Treatment Effect of Sirolimus on Pediatric Pulmonary Vein Stenosis Using a Neonatal Rat Model Induced by Bilateral Pulmonary Vein Banding 西罗莫司对双侧肺静脉束带诱导的新生大鼠肺静脉狭窄的治疗效果评价

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-01 DOI: 10.1016/j.jacbts.2025.04.010

Kathy J. Jenkins MD, MPH

引用次数: 0

C-Reactive Protein as a Potential Signpost to Trained Immunity c反应蛋白作为训练免疫的潜在标志

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-07-01 DOI: 10.1016/j.jacbts.2025.101319

Robin P. Choudhury DM

引用次数: 0

JACC: Basic to Translational Science 2016-2025 JACC：转化科学基础- 2016-2025