Debao Li MD , Yingying Xiao MD , Peisen Ruan MD, PhD , Zunmin Wan PhD , Yuqing Hu MD, PhD , Sijuan Sun MD, PhD , Zheng Wang MD , Sixie Zheng MD , Yi Yan PhD , Hao Chen MD, PhD , Hao Zhang MD, PhD , Chun Shen MD, PhD , Qi Sun MD, PhD , Lincai Ye MD, PhD
{"title":"Evaluation of Treatment Effect of Sirolimus on Pediatric Pulmonary Vein Stenosis Using a Neonatal Rat Model","authors":"Debao Li MD , Yingying Xiao MD , Peisen Ruan MD, PhD , Zunmin Wan PhD , Yuqing Hu MD, PhD , Sijuan Sun MD, PhD , Zheng Wang MD , Sixie Zheng MD , Yi Yan PhD , Hao Chen MD, PhD , Hao Zhang MD, PhD , Chun Shen MD, PhD , Qi Sun MD, PhD , Lincai Ye MD, PhD","doi":"10.1016/j.jacbts.2025.01.010","DOIUrl":"10.1016/j.jacbts.2025.01.010","url":null,"abstract":"<div><div>A modified neonatal rat model of pulmonary vein stenosis (PVS) via bilateral pulmonary vein banding was introduced for the first time, providing a platform for understanding the pathophysiology of PVS and developing treatments. In addition, using this model, the mTOR inhibitor sirolimus was evaluated as a treatment for PVS and exhibited significant therapeutic effects, indicating the need for accelerated ethics approval in clinical settings where sirolimus is not yet in use.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 7","pages":"Article 101229"},"PeriodicalIF":8.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gregory N. Milburn BS , Jania Bell BS , Austin G. Wellette-Hunsucker MS , Hollings Ruml , Andrew T. Yackzan MS , Kenneth S. Campbell PhD
{"title":"Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis","authors":"Gregory N. Milburn BS , Jania Bell BS , Austin G. Wellette-Hunsucker MS , Hollings Ruml , Andrew T. Yackzan MS , Kenneth S. Campbell PhD","doi":"10.1016/j.jacbts.2025.03.003","DOIUrl":"10.1016/j.jacbts.2025.03.003","url":null,"abstract":"<div><div>Amyloid transthyretin cardiac amyloidosis is one of the most common infiltrative cardiomyopathies. Contractile, biochemical, and histological assays were performed on myocardium from patients with and without amyloid transthyretin amyloidosis. Force was reduced in amyloidosis, but calcium sensitivity was increased. The change in calcium sensitivity may reflect dephosphorylation of troponin I. The proportion of stiffness attributable to the extracellular matrix was larger in amyloidosis. Septal fibrosis and amyloid burden correlated with measurements from LV samples. Technetium pyrophosphate scans may detect increased microcalcifications in amyloidosis myocardium. Replacement of myocytes with extracellular matrix is the most important factor depressing contractile force in amyloidosis myocardium.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 7","pages":"Article 101271"},"PeriodicalIF":8.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luge Li BS , Cristian Coarfa PhD , Yue Yuan MD, PhD , Issam Abu-Taha Dr sc hum , Xiaolei Wang PhD , Jia Song MD, MS , Yuying Zeng MS , Xiaohui Chen PhD , Amrit Koirala PhD , Sandra L. Grimm PhD , Markus Kamler MD , Lisa K. McClendon PhD , Michelle Tallquist PhD , Stanley Nattel MD , Dobromir Dobrev MD , Na Li PhD
{"title":"Fibroblast-Restricted Inflammasome Activation Promotes Atrial Fibrillation and Heart Failure With Diastolic Dysfunction","authors":"Luge Li BS , Cristian Coarfa PhD , Yue Yuan MD, PhD , Issam Abu-Taha Dr sc hum , Xiaolei Wang PhD , Jia Song MD, MS , Yuying Zeng MS , Xiaohui Chen PhD , Amrit Koirala PhD , Sandra L. Grimm PhD , Markus Kamler MD , Lisa K. McClendon PhD , Michelle Tallquist PhD , Stanley Nattel MD , Dobromir Dobrev MD , Na Li PhD","doi":"10.1016/j.jacbts.2025.02.004","DOIUrl":"10.1016/j.jacbts.2025.02.004","url":null,"abstract":"<div><div>Atrial fibrillation (AF) often coexists with heart failure, both involving inflammatory signaling and cardiac fibroblasts. To understand the role of fibroblast NLR family pyrin domain containing 3 (NLRP3) inflammasome in cardiac function, we found that <em>NLRP3</em> was up-regulated in atrial fibroblasts from AF patients. Fibroblast-specific activation of NLRP3 in mice induced AF-promoting atrial myopathy and heart failure with diastolic dysfunction, accompanied by increased fibrosis, and reduced conduction velocity. Knockdown of NLRP3 prevented the AF-promoting atrial substrate and cardiomyopathy in the context of NLRP3 activation in fibroblasts. We identify the fibroblast NLRP3 inflammasome as a key pathway governing the promotion of proarrhythmic fibrosis in AF and cardiomyopathy.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 7","pages":"Article 101244"},"PeriodicalIF":8.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harlan M. Krumholz MD, SM (Editor-in-Chief, JACC), Biykem Bozkurt MD, PhD (Editor-in-Chief, JACC: Heart Failure), Y. Chandrashekhar MD (Editor-in-Chief, JACC: Cardiovascular Imaging), Bonnie Ky MD, MSCE (Editor-in-Chief, JACC: CardioOncology), Douglas L. Mann MD (Editor-in-Chief, JACC: Basic to Translational Science), David J. Moliterno MD (Editor-in-Chief, JACC: Cardiovascular Interventions), Kalyanam Shivkumar MD, PhD (Editor-in-Chief, JACC: Clinical Electrophysiology), Candice K. Silversides MD (Editor-in-Chief, JACC: Advances), Gilbert H.L. Tang MD, MSc, MBA (Editor-in-Chief, JACC: Case Reports), Jian’an Wang MD, PhD (Editor-in-Chief, JACC: Asia)
{"title":"Articulating the JACC Journals’ Direction in Times of Global Change","authors":"Harlan M. Krumholz MD, SM (Editor-in-Chief, JACC), Biykem Bozkurt MD, PhD (Editor-in-Chief, JACC: Heart Failure), Y. Chandrashekhar MD (Editor-in-Chief, JACC: Cardiovascular Imaging), Bonnie Ky MD, MSCE (Editor-in-Chief, JACC: CardioOncology), Douglas L. Mann MD (Editor-in-Chief, JACC: Basic to Translational Science), David J. Moliterno MD (Editor-in-Chief, JACC: Cardiovascular Interventions), Kalyanam Shivkumar MD, PhD (Editor-in-Chief, JACC: Clinical Electrophysiology), Candice K. Silversides MD (Editor-in-Chief, JACC: Advances), Gilbert H.L. Tang MD, MSc, MBA (Editor-in-Chief, JACC: Case Reports), Jian’an Wang MD, PhD (Editor-in-Chief, JACC: Asia)","doi":"10.1016/j.jacbts.2025.02.001","DOIUrl":"10.1016/j.jacbts.2025.02.001","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 7","pages":"Article 101241"},"PeriodicalIF":8.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kevin M. Blum MD, PhD , Mackenzie E. Turner MS , Erica L. Schwarz PhD , Cameron A. Best MD, PhD , John M. Kelly MD , Andrew R. Yates MD , Kan N. Hor MD , Yuichi Matsuzaki MD, PhD , Joseph D. Drews MD , Jason Zakko MD , Kejal Shah MD , Toshiharu Shinoka MD, PhD , Jay D. Humphrey PhD , Alison L. Marsden PhD , Christopher K. Breuer MD
{"title":"Oversized Conduits Predict Stenosis in Tissue Engineered Vascular Grafts","authors":"Kevin M. Blum MD, PhD , Mackenzie E. Turner MS , Erica L. Schwarz PhD , Cameron A. Best MD, PhD , John M. Kelly MD , Andrew R. Yates MD , Kan N. Hor MD , Yuichi Matsuzaki MD, PhD , Joseph D. Drews MD , Jason Zakko MD , Kejal Shah MD , Toshiharu Shinoka MD, PhD , Jay D. Humphrey PhD , Alison L. Marsden PhD , Christopher K. Breuer MD","doi":"10.1016/j.jacbts.2025.02.008","DOIUrl":"10.1016/j.jacbts.2025.02.008","url":null,"abstract":"<div><div>Tissue-engineered vascular grafts (TEVGs) offer promising advancements in treating congenital heart disease by enabling the creation of autologous tissue for complex cardiac repairs. Our approach involves implanting biodegradable scaffolds seeded with autologous cells that remodel into functional neovessels. To understand better the factors guiding neovessel formation, we evaluated 50 ovine thoracic TEVGs using angiography at 1 and 6 weeks postimplantation. Nondimensionalization accounted for anatomical differences between animals and identified hemodynamics and surgical sizing as potential driving factors. Regression analysis revealed that narrowing at the inflow anastomosis and graft oversizing correlated significantly with stenosis development. Computational fluid dynamics showed that these factors influenced wall shear stress and flow patterns, contributing to neovessel narrowing. Comparisons with clinical trial data from Fontan conduits supported these findings, emphasizing that matching graft size to the native inflow vessel can reduce stenosis and enhance TEVG performance.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 7","pages":"Article 101248"},"PeriodicalIF":8.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Potential Molecular Mechanism of FNDC4 Protection Against Aging in the Heart","authors":"Masato Matsushita MD, PhD, Junichi Sadoshima MD, PhD","doi":"10.1016/j.jacbts.2025.04.018","DOIUrl":"10.1016/j.jacbts.2025.04.018","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 7","pages":"Article 101304"},"PeriodicalIF":8.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)
{"title":"Recognizing Early Career Translational Investigators","authors":"Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2025.101336","DOIUrl":"10.1016/j.jacbts.2025.101336","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 7","pages":"Article 101336"},"PeriodicalIF":8.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bart Meyns MD, PhD , Randi J. Parks PhD , Erik Verbeken MD, PhD , Manon van Hecke MD , Steven Jacobs MD, PhD , Magdalena Sikole MD , Charlotte Van Edom MD , Eveline Bennek Schoepping PhD , Piet Claus PhD
{"title":"Transvalvular Mechanical Circulatory Support Reverse Remodels the Ischemic Chronic Failing Heart in an Ovine Model","authors":"Bart Meyns MD, PhD , Randi J. Parks PhD , Erik Verbeken MD, PhD , Manon van Hecke MD , Steven Jacobs MD, PhD , Magdalena Sikole MD , Charlotte Van Edom MD , Eveline Bennek Schoepping PhD , Piet Claus PhD","doi":"10.1016/j.jacbts.2025.01.003","DOIUrl":"10.1016/j.jacbts.2025.01.003","url":null,"abstract":"<div><div>Sixteen sheep with ischemic chronic heart failure were randomized to either 3 months of Impella 5.5 support (Abiomed) or sham. Myocardial reverse remodeling by Impella support was shown by a significant reduction of end-diastolic volume (Impella 22% reduction, and control 5% increase; <em>P =</em> 0.011) and end-systolic volume (Impella 20% reduction, and control 11% increase; <em>P =</em> 0.011). Functional measurements demonstrated improved regional ejection fraction and wall thickening in the viable myocardium of hearts supported with Impella. Supported animals had a significant decrease in wall volume, with less cardiomyocyte hypertrophy than control subjects.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 7","pages":"Article 101221"},"PeriodicalIF":8.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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