Evaluation of Treatment Effect of Sirolimus on Pediatric Pulmonary Vein Stenosis Using a Neonatal Rat Model

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2025-07-01 DOI:10.1016/j.jacbts.2025.01.010

Debao Li MD , Yingying Xiao MD , Peisen Ruan MD, PhD , Zunmin Wan PhD , Yuqing Hu MD, PhD , Sijuan Sun MD, PhD , Zheng Wang MD , Sixie Zheng MD , Yi Yan PhD , Hao Chen MD, PhD , Hao Zhang MD, PhD , Chun Shen MD, PhD , Qi Sun MD, PhD , Lincai Ye MD, PhD

引用次数: 0

Abstract

A modified neonatal rat model of pulmonary vein stenosis (PVS) via bilateral pulmonary vein banding was introduced for the first time, providing a platform for understanding the pathophysiology of PVS and developing treatments. In addition, using this model, the mTOR inhibitor sirolimus was evaluated as a treatment for PVS and exhibited significant therapeutic effects, indicating the need for accelerated ethics approval in clinical settings where sirolimus is not yet in use.

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西罗莫司对新生儿大鼠肺静脉狭窄治疗效果的评价。

本文首次建立了改良的双侧肺静脉带束新生大鼠肺静脉狭窄（PVS）模型，为了解PVS的病理生理机制和制定治疗方案提供了平台。此外，使用该模型，mTOR抑制剂西罗莫司被评估为PVS的治疗方法，并显示出显著的治疗效果，这表明在西罗莫司尚未使用的临床环境中，需要加速伦理审批。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.