JACC: Basic to Translational Science最新文献_第2页

Semaglutide Modulates Proinflammatory Epicardial Adipogenesis With Paracrine Effects on hiPSC-Atrial Cardiomyocytes Semaglutide通过旁分泌作用调节hipsc -心房心肌细胞的促炎性心外膜脂肪形成。

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-09-01 DOI: 10.1016/j.jacbts.2025.03.009

Rumeysa Basdas MSc , José Manuel Martínez-Cereijo MD, PhD , Ángel L. Fernández MD, PhD , Laura Reija MD , Alba Cabaleiro MSc , Susana Belén Bravo PhD , José R. González-Juanatey MD, PhD , Sonia Eiras PhD

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The Past, Present, and Promising Future of Direct Cardiac Compression Devices 心脏直接压迫装置的过去、现在和未来。

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-09-01 DOI: 10.1016/j.jacbts.2025.02.013

Melanie P. Hager , Paulamy Ganguly , George V. Letsou

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Effect of Semaglutide on Epicardial Adipogenesis and hiPSC-Atrial Cardiomyocytes New Hope in Targeting Epicardial Adipose Tissue 西马鲁肽对心外膜脂肪形成及hipsc -心房心肌细胞的影响心外膜脂肪组织靶向的新希望

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-09-01 DOI: 10.1016/j.jacbts.2025.101349

Bénédicte Gaborit MD, PhD

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A Gut Feeling 直觉

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-09-01 DOI: 10.1016/j.jacbts.2025.101373

Lewis J. Rubin MD

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Endocardial Fibrosis Elastosis 心内膜纤维化弹性增生：长期的谜团和有希望的治疗。

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-09-01 DOI: 10.1016/j.jacbts.2025.101317

Marlin Touma MD, PhD

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Preclinical Assessment of Atorvastatin for Treatment of Endocardial Fibroelastosis 阿托伐他汀治疗心内膜纤维弹性增生的临床前评价。

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-09-01 DOI: 10.1016/j.jacbts.2025.03.014

Daniel Diaz-Gil MD , Gregor Gierlinger MD , Natalia Silva-Gomez Cand Med , Lavinia Rech MD, PhD , Jesus Ortiz-Urbina MD , Kerstin Saraci Cand Med , Sophia Koutsogiannaki PhD , Cordula M. Wolf MD , Rainer G. Kozlik-Feldmann MD , Rudolf Mair MD , Juan M. Melero-Martin PhD , Sitaram M. Emani MD , Guillermo García-Cardeña PhD , Pedro J. del Nido MD , Ingeborg Friehs MD

{"title":"Preclinical Assessment of Atorvastatin for Treatment of Endocardial Fibroelastosis","authors":"Daniel Diaz-Gil MD , Gregor Gierlinger MD , Natalia Silva-Gomez Cand Med , Lavinia Rech MD, PhD , Jesus Ortiz-Urbina MD , Kerstin Saraci Cand Med , Sophia Koutsogiannaki PhD , Cordula M. Wolf MD , Rainer G. Kozlik-Feldmann MD , Rudolf Mair MD , Juan M. Melero-Martin PhD , Sitaram M. Emani MD , Guillermo García-Cardeña PhD , Pedro J. del Nido MD , Ingeborg Friehs MD","doi":"10.1016/j.jacbts.2025.03.014","DOIUrl":"10.1016/j.jacbts.2025.03.014","url":null,"abstract":"<div><div>Endocardial fibroelastosis is a condition caused by the fibrogenic activation of endothelial cells via endothelial-to-mesenchymal transition of the endocardium, which is regulated by the transforming growth factor-β pathway. Atorvastatin, a statin, can protect the vascular endothelium by up-regulating KLF2 and inhibiting the transforming growth factor-β pathway. This study aimed to investigate the effects of atorvastatin on the fibrogenic activation of endothelial cells in the endocardium. The study found that atorvastatin treatment reduced fibrogenic activation of endocardial endothelial cells and increased KLF2 expression in both in vitro and in vivo models of endocardial fibroelastosis–related left ventricular restriction.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 9","pages":"Article 101282"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T Cells, Triglycerides, and the Immune Roots of Residual Cardiovascular Risk T细胞、甘油三酯和残余心血管风险的免疫根源

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-09-01 DOI: 10.1016/j.jacbts.2025.101376

Michael D. Shapiro DO, MCR

引用次数: 0

Recognizing Early Career Translational Investigators 认识早期职业翻译研究者

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-09-01 DOI: 10.1016/j.jacbts.2025.101377

Matthias Nahrendorf MD, PhD (Editor-in-Chief: JACC: Basic to Translational Science)

引用次数: 0

Triglycerides and T Cells in Cardiovascular Risk 甘油三酯和T细胞在心血管风险中的作用

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-08-21 DOI: 10.1016/j.jacbts.2025.101359

Nathalie A. Reilly PhD , Janneke W.C.M. Mulder MD , Koen F. Dekkers PhD , Thomas B. Kuipers BSc , Leonie C. van Vark-van der Zee BSc , Monique T. Mulder PhD , Jeanine E. Roeters van Lennep MD, PhD , J. Wouter Jukema MD, PhD , Bastiaan T. Heijmans PhD

{"title":"Triglycerides and T Cells in Cardiovascular Risk","authors":"Nathalie A. Reilly PhD , Janneke W.C.M. Mulder MD , Koen F. Dekkers PhD , Thomas B. Kuipers BSc , Leonie C. van Vark-van der Zee BSc , Monique T. Mulder PhD , Jeanine E. Roeters van Lennep MD, PhD , J. Wouter Jukema MD, PhD , Bastiaan T. Heijmans PhD","doi":"10.1016/j.jacbts.2025.101359","DOIUrl":"10.1016/j.jacbts.2025.101359","url":null,"abstract":"<div><div>Triglycerides and T cells play a key role in atherosclerosis, the leading cause of cardiovascular disease (CVD). Moderately elevated triglycerides have emerged as a causal risk factor, and T cells are a prominent component of atherosclerotic plaques. This cross-sectional study examined transcriptomic differences in T cells among patients with varying triglyceride levels via RNA sequencing. We analyzed CD4<sup>+</sup> and CD8<sup>+</sup> T cells from 49 participants, including those with primary (genetic) and secondary moderate hypertriglyceridemia, severe hypertriglyceridemia, and hypotriglyceridemia. Patients with primary moderate hypertriglyceridemia exhibited a proinflammatory transcriptomic profile, including increased interleukin-6 receptor (<em>IL6R</em>) expression, which is implicated in CVD risk. Similar patterns appeared in CD8<sup>+</sup> T cells and, to a lesser extent, in secondary moderate hypertriglyceridemia patients. Conversely, transcriptomic differences were reversed in hypotriglyceridemia and absent in severe hypertriglyceridemia patients. These findings suggest that elevated triglycerides may contribute to CVD by promoting a proinflammatory transcriptomic profile in T cells.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 9","pages":"Article 101359"},"PeriodicalIF":8.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision Medicine 精密医学

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2025-08-21 DOI: 10.1016/j.jacbts.2025.101345

Alex M. Parker MBiomedSc , Jarmon G. Lees PhD , Andrew J. Murray PhD , Anida Velagic PhD , Shiang Y. Lim MPharm, PhD , Miles J. De Blasio PhD , Rebecca H. Ritchie PhD

{"title":"Precision Medicine","authors":"Alex M. Parker MBiomedSc , Jarmon G. Lees PhD , Andrew J. Murray PhD , Anida Velagic PhD , Shiang Y. Lim MPharm, PhD , Miles J. De Blasio PhD , Rebecca H. Ritchie PhD","doi":"10.1016/j.jacbts.2025.101345","DOIUrl":"10.1016/j.jacbts.2025.101345","url":null,"abstract":"<div><div>A substantial component of the increasing global burden of cardiovascular disease is attributed to heart failure (HF), affecting over 64 million adults worldwide. Maladaptive mitochondrial respiratory alterations and oxidative stress are major contributors to HF development and progression, with subsequent downstream myocardial energetic impairment as a strong predictor of mortality. Current conventional therapeutic approaches, including renin-angiotensin-aldosterone system inhibition and β-adrenergic blockade, target neurohormonal aspects of HF and are effective in slowing disease progression. However, although these therapies may be associated with some improvement in myocardial energetics, they do not specifically address alterations in myocardial mitochondrial respiration or redox homeostasis. Targeting mitochondria has hence become a promising approach for more effective and tailored therapies. This review summarizes metabolic derangements that drive HF progression, with a specific focus on mitochondria. Importantly, here we address the essential knowledge gaps in the field, highlighting key translational strategies used to date, and the challenges associated with therapeutically targeting mitochondrial pathways, alongside recent developments seeking to deploy novel mitochondrial-targeted therapeutic approaches to treat HF.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 9","pages":"Article 101345"},"PeriodicalIF":8.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0