JACC: Basic to Translational Science最新文献_第2页

Recognizing Early Career Translational Investigators 表彰早期职业转化研究人员

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-10-01 DOI: 10.1016/j.jacbts.2024.09.001

Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)

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Viewing Pulmonary Arterial Hypertension Pathogenesis and Opportunities for Disease-Modifying Therapy Through the Lens of Biomass 从生物质角度看肺动脉高压发病机制和疾病调节疗法的机遇

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-10-01 DOI: 10.1016/j.jacbts.2024.04.009

Matthew L. Steinhauser MD , Bradley A. Maron MD

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PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia PCSK9 抗体治疗特异性地增强了杂合子家族性高胆固醇血症患者巨噬细胞特异性胆固醇逆向转运途径的功能

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-10-01 DOI: 10.1016/j.jacbts.2024.06.008

Carla Borràs MSc , Marina Canyelles PhD , Josefa Girona PhD , Daiana Ibarretxe MD, PhD , David Santos BS , Giovanna Revilla PhD , Vicenta Llorente-Cortes PhD , Noemí Rotllan PhD , Petri T. Kovanen MD, PhD , Matti Jauhiainen PhD , Miriam Lee-Rueckert PhD , Luis Masana MD, PhD , Francisco Arrieta MD, PhD , Javier Martínez-Botas PhD , Diego Gómez-Coronado PhD , Josep Ribalta PhD , Mireia Tondo PhD , Francisco Blanco-Vaca MD, PhD , Joan Carles Escolà-Gil PhD

{"title":"PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia","authors":"Carla Borràs MSc , Marina Canyelles PhD , Josefa Girona PhD , Daiana Ibarretxe MD, PhD , David Santos BS , Giovanna Revilla PhD , Vicenta Llorente-Cortes PhD , Noemí Rotllan PhD , Petri T. Kovanen MD, PhD , Matti Jauhiainen PhD , Miriam Lee-Rueckert PhD , Luis Masana MD, PhD , Francisco Arrieta MD, PhD , Javier Martínez-Botas PhD , Diego Gómez-Coronado PhD , Josep Ribalta PhD , Mireia Tondo PhD , Francisco Blanco-Vaca MD, PhD , Joan Carles Escolà-Gil PhD","doi":"10.1016/j.jacbts.2024.06.008","DOIUrl":"10.1016/j.jacbts.2024.06.008","url":null,"abstract":"<div><div>We investigated the potential of proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies to restore macrophage cholesterol efflux in subjects with heterozygous familial hypercholesterolemia (FH) and to enhance the macrophage-specific reverse cholesterol transport pathway in mice. Analyses of macrophage-derived cholesterol distribution of plasma from FH patients revealed that low-density lipoprotein (LDL) particles contained less, and high-density lipoprotein particles contained more radiolabeled cholesterol after treatment with either PCSK9 inhibitor. PCSK9 antibodies facilitated the transfer of macrophage-derived cholesterol and LDL-derived cholesterol to feces exclusively in heterozygous LDL receptor-deficient mice expressing human APOB100. PCSK9 inhibitors act as positive regulators of the macrophage-specific reverse cholesterol transport pathway in individuals with heterozygous FH.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 10","pages":"Pages 1195-1210"},"PeriodicalIF":8.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-Based Probe Reveals the Presence of Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients 基于结构的探针揭示了 ATTR 淀粉样变性患者血浆中存在大量的转甲状腺素聚集体

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.05.013

Rose Pedretti BS , Lanie Wang BS , Anna Yakubovska MS , Qiongfang S. Zhang BS , Binh Nguyen PhD , Justin L. Grodin MD , Ahmad Masri MD , Lorena Saelices PhD

{"title":"Structure-Based Probe Reveals the Presence of Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients","authors":"Rose Pedretti BS , Lanie Wang BS , Anna Yakubovska MS , Qiongfang S. Zhang BS , Binh Nguyen PhD , Justin L. Grodin MD , Ahmad Masri MD , Lorena Saelices PhD","doi":"10.1016/j.jacbts.2024.05.013","DOIUrl":"10.1016/j.jacbts.2024.05.013","url":null,"abstract":"<div><div>Amyloidogenic transthyretin (ATTR) amyloidosis is a relentlessly progressive disease caused by the misfolding and systemic accumulation of amyloidogenic transthyretin into amyloid fibrils. These fibrils cause diverse clinical phenotypes, mainly cardiomyopathy and/or polyneuropathy. Little is known about the aggregation of transthyretin during disease development and whether this has implications for diagnosis and treatment. Using the cryogenic electron microscopy structures of mature ATTR fibrils, we developed a peptide probe for fibril detection. With this probe, we have identified previously unknown aggregated transthyretin species in plasma of patients with ATTR amyloidosis. These species are large, non-native, and distinct from monomeric and tetrameric transthyretin. Observations from our study open many questions about the biology of ATTR amyloidosis and reveal a potential diagnostic and therapeutic target.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 9","pages":"Pages 1088-1100"},"PeriodicalIF":8.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002201/pdfft?md5=5b6a105e3917c13332161203cd4e2112&pid=1-s2.0-S2452302X24002201-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recognizing Early Career Translational Investigators 表彰早期职业转化研究人员

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.07.010

Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)

引用次数: 0

Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients ATTR 淀粉样变性患者血浆中的大颗粒转甲状腺素聚集体

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.07.005

Marianna Fontana MD, PhD, Julian D. Gillmore MD, PhD, Guglielmo Verona PhD

引用次数: 0

TRIM55 Aggravates Cardiomyocyte Apoptosis After Myocardial Infarction via Modulation of the Nrf2/HO-1 Pathway TRIM55 通过调节 Nrf2/HO-1 通路加剧心肌梗死后的心肌细胞凋亡

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.05.006

Yuxin Bu MM , Yanxia Liu MD , Meili Liu MD, Chenghui Yan MD, Jing Wang MM, Hanlin Wu MM, Haixu Song MD, Dali Zhang MD, Kai Xu MD, Dan Liu MD, Yaling Han MD, PhD

引用次数: 0

Interferon Interrupted 干扰素中断

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.06.011

Harvey G. Roweth PhD

引用次数: 0

Inhibiting the P2Y12 Receptor in Megakaryocytes and Platelets Suppresses Interferon-Associated Responses 抑制巨核细胞和血小板中的 P2Y12 受体可抑制干扰素相关反应

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.05.014

Marcin A. Sowa PhD , Haoyu Sun PhD , Tricia T. Wang BA , Vitor W. Virginio PhD , Florencia Schlamp PhD , Hanane El Bannoudi PhD , MacIntosh Cornwell PhD , Hannah Bash BA , Peter M. Izmirly MD , H. Michael Belmont MD , Kelly V. Ruggles PhD , Jill P. Buyon MD , Deepak Voora MD , Tessa J. Barrett PhD , Jeffrey S. Berger MD

{"title":"Inhibiting the P2Y12 Receptor in Megakaryocytes and Platelets Suppresses Interferon-Associated Responses","authors":"Marcin A. Sowa PhD , Haoyu Sun PhD , Tricia T. Wang BA , Vitor W. Virginio PhD , Florencia Schlamp PhD , Hanane El Bannoudi PhD , MacIntosh Cornwell PhD , Hannah Bash BA , Peter M. Izmirly MD , H. Michael Belmont MD , Kelly V. Ruggles PhD , Jill P. Buyon MD , Deepak Voora MD , Tessa J. Barrett PhD , Jeffrey S. Berger MD","doi":"10.1016/j.jacbts.2024.05.014","DOIUrl":"10.1016/j.jacbts.2024.05.014","url":null,"abstract":"<div><div>The authors investigated the impact of antiplatelet therapy on the megakaryocyte (MK) and platelet transcriptome. RNA-sequencing was performed on MKs treated with aspirin or P2Y<sub>12</sub> inhibitor, platelets from healthy volunteers receiving aspirin or P2Y<sub>12</sub> inhibition, and platelets from patients with systemic lupus erythematosus (SLE). P2Y<sub>12</sub> inhibition reduced gene expression and inflammatory pathways in MKs and platelets. In SLE, the interferon (IFN) pathway was elevated. In vitro experiments demonstrated the role of P2Y<sub>12</sub> inhibition in reducing IFNα-induced platelet-leukocyte interactions and IFN signaling pathways. These results suggest that P2Y<sub>12</sub> inhibition may have therapeutic potential for proinflammatory and autoimmune conditions like SLE.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 9","pages":"Pages 1126-1140"},"PeriodicalIF":8.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002213/pdfft?md5=7f2c6a99acc7a7dc4600a00905868755&pid=1-s2.0-S2452302X24002213-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant ICAM1 p.K56M HFpEF 风险变异体的蛋白质组概况

IF 8.4 1区医学

JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.05.016

Pedro Giro MD , Mallory Filipp PhD , Michael J. Zhang MD, PhD , Ethan D. Moser MPH , Edward B. Thorp PhD , Prarthana J. Dalal MD, PhD , Ravi V. Shah MD , Patrick T. Ellinor MD, PhD , Jonathan W. Cunningham MD , Sean J. Jurgens MD, MSc , Arjun Sinha MD, MSc , Laura Rasmussen-Torvik PhD, MPH , Jorge Kizer MD, MSc , Kent D. Taylor PhD , Philip Greenland MD , Bruce M. Psaty MD, PhD , Russell P. Tracy PhD , Lin Yee Chen MD, MS , Amil M. Shah MD , Bing Yu PhD , Ravi B. Patel MD, MSc

{"title":"Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant","authors":"Pedro Giro MD , Mallory Filipp PhD , Michael J. Zhang MD, PhD , Ethan D. Moser MPH , Edward B. Thorp PhD , Prarthana J. Dalal MD, PhD , Ravi V. Shah MD , Patrick T. Ellinor MD, PhD , Jonathan W. Cunningham MD , Sean J. Jurgens MD, MSc , Arjun Sinha MD, MSc , Laura Rasmussen-Torvik PhD, MPH , Jorge Kizer MD, MSc , Kent D. Taylor PhD , Philip Greenland MD , Bruce M. Psaty MD, PhD , Russell P. Tracy PhD , Lin Yee Chen MD, MS , Amil M. Shah MD , Bing Yu PhD , Ravi B. Patel MD, MSc","doi":"10.1016/j.jacbts.2024.05.016","DOIUrl":"10.1016/j.jacbts.2024.05.016","url":null,"abstract":"<div><div>A common missense variant in <em>ICAM1</em> among African American individuals (rs5491; pK56M) has been associated with risk of heart failure with preserved ejection fraction (HFpEF), but the pathways that lead to HFpEF among those with this variant are not clear. In this analysis of 92 circulating proteins and their associated networks, we identified 7 circulating inflammatory proteins associated with rs5491 among >600 African American individuals. Using weighted coexpression network analysis, 3 protein networks were identified, one of which was associated with rs5491. This protein network was most highly represented by members of the tumor necrosis receptor superfamily. The rs5491 variant demonstrated an inflammatory proteomic profile in a separate cohort of African American individuals. This analysis identifies inflammatory pathways that may drive HFpEF among African American individuals with the <em>ICAM1</em> pK56M (rs5491) variant.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 9","pages":"Pages 1073-1084"},"PeriodicalIF":8.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002262/pdfft?md5=6a8e1da15f7d8bf280efb89154fd82d8&pid=1-s2.0-S2452302X24002262-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0