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Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2024.11.011
Naaleum Song PhD , Eunhye Ji PhD , Jeong Eun Yu BS , Kyoung-Hee Choi BS , Dae-Hee Kim MD, PhD , Jong-Min Song MD, PhD , Duk-Hyun Kang MD, PhD , Jae-Kwan Song MD, PhD , Jiyoung Yu PhD , Kyunggon Kim PhD , Sahmin Lee MD, PhD , Elena Aikawa MD, PhD
{"title":"Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification","authors":"Naaleum Song PhD ,&nbsp;Eunhye Ji PhD ,&nbsp;Jeong Eun Yu BS ,&nbsp;Kyoung-Hee Choi BS ,&nbsp;Dae-Hee Kim MD, PhD ,&nbsp;Jong-Min Song MD, PhD ,&nbsp;Duk-Hyun Kang MD, PhD ,&nbsp;Jae-Kwan Song MD, PhD ,&nbsp;Jiyoung Yu PhD ,&nbsp;Kyunggon Kim PhD ,&nbsp;Sahmin Lee MD, PhD ,&nbsp;Elena Aikawa MD, PhD","doi":"10.1016/j.jacbts.2024.11.011","DOIUrl":"10.1016/j.jacbts.2024.11.011","url":null,"abstract":"<div><div>Aortic stenosis (AS) is a severe heart valve disease marked by calcification, leading to heart failure. This study examined mitochondrial function in human aortic valve interstitial cells isolated from patients with AS and tested spermidine, an autophagy inducer as AS treatment. Spermidine treatment reduced fibrosis and calcification in human aortic valve interstitial cells and improved these features in spermidine-treated mice. The AKT-TP53-DNMT1-PPARG pathway was implicated, and DNA methyltransferase 1 inhibition by 5-azacytidine enhanced mitochondrial biogenesis by reducing mitochondrial DNA hypermethylation. These findings suggest that spermidine or DNA methyltransferase 1 inhibition could prevent aortic valve disease by improving mitochondrial function.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 345-366"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous Molecular Monitoring for Precision Heart Failure Care
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.01.016
Alex M. Yoshikawa PhD
{"title":"Continuous Molecular Monitoring for Precision Heart Failure Care","authors":"Alex M. Yoshikawa PhD","doi":"10.1016/j.jacbts.2025.01.016","DOIUrl":"10.1016/j.jacbts.2025.01.016","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 262-263"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Noninvasive System for Remote Monitoring of Left Ventricular Filling Pressures
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.01.008
Allan Böhm MD, PhD , Julia Lucka MD , Nikola Jajcay PhD , Amitai Segev MD , Jana Jankova PhD , Marta Kollarova PhD , Oliver Holly Eng , Viera Sebenova Jerigova PhD , Jana Stevkova MD , Martin Spilak , Filip Skorec , Kristian Guzma MSc , Laura Johanesova , Zoltan Hanesz Eng , Stefan Karolcik PhD , Andrej Remak MSc , Paul A. Sobotka MD, PhD , Branislav Bezak MD, PhD
{"title":"A Noninvasive System for Remote Monitoring of Left Ventricular Filling Pressures","authors":"Allan Böhm MD, PhD ,&nbsp;Julia Lucka MD ,&nbsp;Nikola Jajcay PhD ,&nbsp;Amitai Segev MD ,&nbsp;Jana Jankova PhD ,&nbsp;Marta Kollarova PhD ,&nbsp;Oliver Holly Eng ,&nbsp;Viera Sebenova Jerigova PhD ,&nbsp;Jana Stevkova MD ,&nbsp;Martin Spilak ,&nbsp;Filip Skorec ,&nbsp;Kristian Guzma MSc ,&nbsp;Laura Johanesova ,&nbsp;Zoltan Hanesz Eng ,&nbsp;Stefan Karolcik PhD ,&nbsp;Andrej Remak MSc ,&nbsp;Paul A. Sobotka MD, PhD ,&nbsp;Branislav Bezak MD, PhD","doi":"10.1016/j.jacbts.2025.01.008","DOIUrl":"10.1016/j.jacbts.2025.01.008","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 256-258"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Virtual Patient Simulator
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.01.009
Jonathan Grinstein MD , Pablo J. Blanco PhD , Ryo Torii PhD , Rohan Goswami MD
{"title":"The Virtual Patient Simulator","authors":"Jonathan Grinstein MD ,&nbsp;Pablo J. Blanco PhD ,&nbsp;Ryo Torii PhD ,&nbsp;Rohan Goswami MD","doi":"10.1016/j.jacbts.2025.01.009","DOIUrl":"10.1016/j.jacbts.2025.01.009","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 259-261"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardial Infarction Platelet Gene Expression Signatures in Women
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2024.10.018
Tessa J. Barrett PhD , Florencia Schlamp PhD , Matthew Muller MS , Angela H. Lee BA , Macintosh G. Cornwell PhD , Elliot Luttrell Williams MS , Nathaniel R. Smilowitz MD , Judith Hochman MD , Kelly V. Ruggles PhD , Harmony R. Reynolds MD , Jeffrey S. Berger MD
{"title":"Myocardial Infarction Platelet Gene Expression Signatures in Women","authors":"Tessa J. Barrett PhD ,&nbsp;Florencia Schlamp PhD ,&nbsp;Matthew Muller MS ,&nbsp;Angela H. Lee BA ,&nbsp;Macintosh G. Cornwell PhD ,&nbsp;Elliot Luttrell Williams MS ,&nbsp;Nathaniel R. Smilowitz MD ,&nbsp;Judith Hochman MD ,&nbsp;Kelly V. Ruggles PhD ,&nbsp;Harmony R. Reynolds MD ,&nbsp;Jeffrey S. Berger MD","doi":"10.1016/j.jacbts.2024.10.018","DOIUrl":"10.1016/j.jacbts.2024.10.018","url":null,"abstract":"<div><div>Although platelets play a critical pathogenic role in myocardial infarction (MI), few studies have characterized the MI platelet transcriptome in the acute or chronic setting in women. We report that transcripts associated with the actin cytoskeleton, Rho family GTPases, mitochondrial dysfunction, and inflammatory signaling are enriched in platelets from MI patients in the acute setting (n = 40, MI; n = 38, control) and do not significantly change over time. Furthermore, 79 platelet genes chronically elevated or suppressed after MI are associated with future cardiovascular events in an independent high-risk cohort (n = 135). Compared with women with MI with nonobstructive coronary arteries, platelets from women with MI and obstructive coronary artery disease were enriched in neutrophil activation and proinflammatory signaling pathways driven by increased tumor necrosis factor (TNF)-α signaling. Hierarchic clustering of the MI transcriptomic profile identified 3 subgroups with distinctive biological pathways and MI correlates. Our data demonstrate that platelets from MI patients are phenotypically different from MI-naïve patients in the acute and chronic settings and reveal a platelet transcriptomic signature with distinct clinical features.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 307-322"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2024.12.010
Dipak Panigrahy MD , Abigail G. Kelly BA , Katherine M. Quinlivan BS , Weicang Wang PhD , Jun Yang PhD , Sung Hee Hwang PhD , Michael Gillespie BA , Isabella V. Howard , Carlos Bueno-Beti PhD , Angeliki Asimaki PhD , Vinay Penna BA , Kory Lavine MD, PhD , Matthew L. Edin PhD , Darryl C. Zeldin MD , Bruce D. Hammock PhD , Jeffrey E. Saffitz MD, PhD
{"title":"Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy","authors":"Dipak Panigrahy MD ,&nbsp;Abigail G. Kelly BA ,&nbsp;Katherine M. Quinlivan BS ,&nbsp;Weicang Wang PhD ,&nbsp;Jun Yang PhD ,&nbsp;Sung Hee Hwang PhD ,&nbsp;Michael Gillespie BA ,&nbsp;Isabella V. Howard ,&nbsp;Carlos Bueno-Beti PhD ,&nbsp;Angeliki Asimaki PhD ,&nbsp;Vinay Penna BA ,&nbsp;Kory Lavine MD, PhD ,&nbsp;Matthew L. Edin PhD ,&nbsp;Darryl C. Zeldin MD ,&nbsp;Bruce D. Hammock PhD ,&nbsp;Jeffrey E. Saffitz MD, PhD","doi":"10.1016/j.jacbts.2024.12.010","DOIUrl":"10.1016/j.jacbts.2024.12.010","url":null,"abstract":"<div><div>We analyzed the role of pro- and anti-inflammatory eicosanoids in the pathogenesis of arrhythmogenic cardiomyopathy (ACM). Lipidomics revealed reduced levels of anti-inflammatory oxylipins in plasma and increased levels of pro-inflammatory eicosanoids in hearts of <em>Dsg2</em><sup><em>mut/mut</em></sup> mice, a preclinical model of ACM. Disease features were reversed in vitro in rat ventricular myocytes expressing mutant <em>JUP</em> by the anti-inflammatory epoxyeicosatrienoic acid 14-15-EET, whereas 14,15-EEZE, which antagonizes the 14,15-EET receptor, intensified nuclear accumulation of the desmosomal protein plakoglobin. Inhibition of soluble epoxide hydrolase (sEH), an enzyme that converts anti-inflammatory EETs into polar, less active diols, prevented progression of myocardial injury in <em>Dsg2</em><sup><em>mut/mut</em></sup> mice and promoted recovery of contractile function. This was associated with reduced myocardial expression of genes involved in innate immune signaling and fewer injurious macrophages expressing CCR2. These results suggest that pro-inflammatory eicosanoids contribute to the pathogenesis of ACM. Inhibition of sEH may be an effective, mechanism-based therapy for ACM patients.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 367-380"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Hematopoietic Loss of Y Chromosome With Atrial Fibrillation Incidence and Sex Disparity
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2024.10.012
Tianqi Ma MD , Chen Zhu MB , Xunjie Cheng PhD , Yuanfeng Huang PhD , Jinchen Li PhD , Yu Tan MD , Yongping Bai MD, PhD
{"title":"Association of Hematopoietic Loss of Y Chromosome With Atrial Fibrillation Incidence and Sex Disparity","authors":"Tianqi Ma MD ,&nbsp;Chen Zhu MB ,&nbsp;Xunjie Cheng PhD ,&nbsp;Yuanfeng Huang PhD ,&nbsp;Jinchen Li PhD ,&nbsp;Yu Tan MD ,&nbsp;Yongping Bai MD, PhD","doi":"10.1016/j.jacbts.2024.10.012","DOIUrl":"10.1016/j.jacbts.2024.10.012","url":null,"abstract":"<div><div>Mosaic loss of chromosome Y (mLOY), the most common somatic mutation, prompts fibrotic heart diseases. We hypothesized that it accelerates atrial fibrillation (AF) and contributes to its sex disparity. A total of 214,405 male participants from the UK Biobank without prevalent AF were included, with a median follow-up of 14.31 years. mLOY was associated with a 16% higher AF risk, with 9.6% and 6.4% of the association mediated by neutrophils and monocytes. AF risk of males with mLOY was 98% higher than that of matched females. Thus, mLOY is associated with a slightly increased AF risk, and might partly contribute to sex disparity of AF.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 279-289"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143678413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2024.10.014
Senthil Selvaraj MD, MS, MA , Lydia Coulter Kwee PhD , Elizabeth J. Thompson MD , Mengshu He MS , Christoph P. Hornik MD, PhD , Adam D. Devore MD , Chetan B. Patel MD , Robert J. Mentz MD , Marat Fudim MD, MHS , Lacey Taylor MPH , Stephanie Milosovic DPT , Melissa Hurdle BS , William T. Cade PT, PhD , Olga Ilkayeva PhD , Michael J. Muehlbauer PhD , Christopher B. Newgard PhD , Daniel P. Kelly MD , Payman Zamani MD, MTR , Kenneth B. Margulies MD , Svati H. Shah MD, MS, MHS
{"title":"Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF","authors":"Senthil Selvaraj MD, MS, MA ,&nbsp;Lydia Coulter Kwee PhD ,&nbsp;Elizabeth J. Thompson MD ,&nbsp;Mengshu He MS ,&nbsp;Christoph P. Hornik MD, PhD ,&nbsp;Adam D. Devore MD ,&nbsp;Chetan B. Patel MD ,&nbsp;Robert J. Mentz MD ,&nbsp;Marat Fudim MD, MHS ,&nbsp;Lacey Taylor MPH ,&nbsp;Stephanie Milosovic DPT ,&nbsp;Melissa Hurdle BS ,&nbsp;William T. Cade PT, PhD ,&nbsp;Olga Ilkayeva PhD ,&nbsp;Michael J. Muehlbauer PhD ,&nbsp;Christopher B. Newgard PhD ,&nbsp;Daniel P. Kelly MD ,&nbsp;Payman Zamani MD, MTR ,&nbsp;Kenneth B. Margulies MD ,&nbsp;Svati H. Shah MD, MS, MHS","doi":"10.1016/j.jacbts.2024.10.014","DOIUrl":"10.1016/j.jacbts.2024.10.014","url":null,"abstract":"<div><div>Growing evidence supports therapeutic ketosis in heart failure with reduced ejection fraction, though uncertainty exists regarding use with SGLT2i and dose-dependent effects. In a phase I trial of 2 ketone ester (KE) doses in 20 heart failure with reduced ejection fraction participants, stratified by background SGLT2i, the authors detailed pharmacokinetic parameters, noting rapid ketosis and short half-life. KE was associated with lower non-esterified fatty acid, branched-chain amino acids, and most acylcarnitines (except C2 and C4-OH, which increased); differences were observed by SGLT2i and KE dose. Increases in heart rate and decreases in systolic blood pressure, pH, and bicarbonate were generally transient. KE ingestion induces rapid changes in key metabolic pathways, differentially affected by SGLT2i (fatty acid metabolism) and KE dose (ketone metabolism). Hemodynamic effects were transient and irrespective of dose or SGLT2i. (Ketone Pharmacokinetic Study in HFrEF; <span><span>NCT05757193</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 290-303"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling “Hot Phases” of Arrhythmogenic Cardiomyopathy
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.02.011
Shanshan Gao PhD, Suet Nee Chen PhD, Luisa Mestroni MD
{"title":"Unraveling “Hot Phases” of Arrhythmogenic Cardiomyopathy","authors":"Shanshan Gao PhD,&nbsp;Suet Nee Chen PhD,&nbsp;Luisa Mestroni MD","doi":"10.1016/j.jacbts.2025.02.011","DOIUrl":"10.1016/j.jacbts.2025.02.011","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 381-382"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design of the First in Human Gene Therapy Trial of TLT-101 for Chronic Heart Failure (FIGHT-HF)
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.01.019
Pia Balmaceda MD , Tara C. Hitzeman MPH , Kikuyo E. Shaw BS , Lynn M. Kolhepp BS , Matthew Killeen PhD , James C. Fang MD , Javed Butler MD , Adrian F. Hernandez MD , TingTing Hong MD, PhD , Robin M. Shaw MD, PhD
{"title":"Design of the First in Human Gene Therapy Trial of TLT-101 for Chronic Heart Failure (FIGHT-HF)","authors":"Pia Balmaceda MD ,&nbsp;Tara C. Hitzeman MPH ,&nbsp;Kikuyo E. Shaw BS ,&nbsp;Lynn M. Kolhepp BS ,&nbsp;Matthew Killeen PhD ,&nbsp;James C. Fang MD ,&nbsp;Javed Butler MD ,&nbsp;Adrian F. Hernandez MD ,&nbsp;TingTing Hong MD, PhD ,&nbsp;Robin M. Shaw MD, PhD","doi":"10.1016/j.jacbts.2025.01.019","DOIUrl":"10.1016/j.jacbts.2025.01.019","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 276-278"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143678412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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