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Living Nanofiber-Enabled Cardiac Patches for Myocardial Injury
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-02-01 DOI: 10.1016/j.jacbts.2024.06.010
Sukhwinder K. Bhullar PhD , Raneeta Thingnam MSc , Eryn Kirshenbaum PhD , Darya Nematisouldaragh MSc , Molly Crandall MSc , Stephanie M. Willerth PhD , Seeram Ramkrishna PhD , Inna Rabinovich-Nikitin PhD , Lorrie A. Kirshenbaum PhD
{"title":"Living Nanofiber-Enabled Cardiac Patches for Myocardial Injury","authors":"Sukhwinder K. Bhullar PhD ,&nbsp;Raneeta Thingnam MSc ,&nbsp;Eryn Kirshenbaum PhD ,&nbsp;Darya Nematisouldaragh MSc ,&nbsp;Molly Crandall MSc ,&nbsp;Stephanie M. Willerth PhD ,&nbsp;Seeram Ramkrishna PhD ,&nbsp;Inna Rabinovich-Nikitin PhD ,&nbsp;Lorrie A. Kirshenbaum PhD","doi":"10.1016/j.jacbts.2024.06.010","DOIUrl":"10.1016/j.jacbts.2024.06.010","url":null,"abstract":"<div><div>Because the adult heart has only minimal regenerative capacity, its inability to induce regeneration is well-known in patients with myocardial infarction. However, based on multidisciplinary approaches, it is possible to restore myocardial capability with regenerative medicine via living cardiac patches seeded with therapeutic ingredients ranging from multiple cell types to bioactive molecules, including growth factors, microRNA, and extracellular vesicles to the affected site. Biomaterials, natural and/or synthesized polymers, or in vivo sources such as collagen, fibrin, and decellularized extracellular matrix are used to form these cardiac patches. Herein, we review various techniques where seeded cells and bioactive agents are incorporated within porous nanofibers to create functional cardiac patches that provide myocardial extracellular matrix–like features, mechanical support, and a large surface-to-volume ratio for promoting cellular metabolism as well as compensation for the loss of cardiomyocytes in the infarcted region. We summarize recent advances through electrospinning-generated nanofibers of synthetic and/or natural polymers combined with biological material to create cardiac patches to repair and improve the function of infarcted myocardium. As tailoring designs on cardiac patches have been shown to exhibit deformation mechanisms and enhanced myocardial tissue regeneration, significant roles of various patterns and associated parameters are also discussed. The enhanced delivery of therapeutics offered by tailored nanofiber cardiac patches to treat myocardial infarction and overcome challenges of existing cardiac regeneration therapies such as low stability, short half-lifetime, and delivery methods may promote the potential for their clinical impact on myocardial regeneration.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 2","pages":"Pages 227-240"},"PeriodicalIF":8.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CircBTBD7-420aa Encoded by hsa_circ_0000563 Regulates the Progression of Atherosclerosis and Construction of circBTBD7-420aa Engineered Exosomes
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-02-01 DOI: 10.1016/j.jacbts.2024.09.003
Xiongkang Gan MD , Boyu Chi MD , Xin Zhang MS , Mengmeng Ren MS , Hengjie Bie MS , Qiaowei Jia MD , Yahong Fu MD , Chengcheng Li MS , Hanxiao Zhou MS , Shu He MS , Yanjun Wang MS , Yuli Chen MD , Sheng Zhang MD , Qian Zhang MD , Zhenyu Zhao BS , Weixin Sun MD , Qiangba Yangzong MD , Ciren Zhongga MD , Renyou Pan MD , Xiumei Chen MD, PhD , Enzhi Jia MD, PhD
{"title":"CircBTBD7-420aa Encoded by hsa_circ_0000563 Regulates the Progression of Atherosclerosis and Construction of circBTBD7-420aa Engineered Exosomes","authors":"Xiongkang Gan MD ,&nbsp;Boyu Chi MD ,&nbsp;Xin Zhang MS ,&nbsp;Mengmeng Ren MS ,&nbsp;Hengjie Bie MS ,&nbsp;Qiaowei Jia MD ,&nbsp;Yahong Fu MD ,&nbsp;Chengcheng Li MS ,&nbsp;Hanxiao Zhou MS ,&nbsp;Shu He MS ,&nbsp;Yanjun Wang MS ,&nbsp;Yuli Chen MD ,&nbsp;Sheng Zhang MD ,&nbsp;Qian Zhang MD ,&nbsp;Zhenyu Zhao BS ,&nbsp;Weixin Sun MD ,&nbsp;Qiangba Yangzong MD ,&nbsp;Ciren Zhongga MD ,&nbsp;Renyou Pan MD ,&nbsp;Xiumei Chen MD, PhD ,&nbsp;Enzhi Jia MD, PhD","doi":"10.1016/j.jacbts.2024.09.003","DOIUrl":"10.1016/j.jacbts.2024.09.003","url":null,"abstract":"<div><div>Circular RNAs are associated with cardiovascular disease, including coronary artery disease, but the mechanisms have not been completely elucidated. We found a new protein, circBTBD7-420aa, encoded by hsa_circ_0000563. Our results suggest that circBTBD7-420aa may inhibit the abnormal proliferation and migration of human coronary artery smooth muscle cells by promoting SLC3A2 degradation through the ubiquitin-proteasome pathway. In addition, we constructed engineered exosomes loaded with circBTBD7-420aa that can target vascular smooth muscle cells by modifying peptide fragments targeting osteopontin. This study suggests that circBTBD7-420aa may inhibit the progression of atherosclerosis and serve as a new target for the diagnosis and treatment of coronary artery disease.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 2","pages":"Pages 131-147"},"PeriodicalIF":8.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translating Translation
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-02-01 DOI: 10.1016/j.jacbts.2024.10.011
Tobias Jakobi PhD
{"title":"Translating Translation","authors":"Tobias Jakobi PhD","doi":"10.1016/j.jacbts.2024.10.011","DOIUrl":"10.1016/j.jacbts.2024.10.011","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 2","pages":"Pages 148-151"},"PeriodicalIF":8.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endothelial JCAD Worsens Acute Ischemic Stroke Outcomes by Enhancing Inflammation in Response to Ischemia/Reperfusion
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-02-01 DOI: 10.1016/j.jacbts.2024.09.009
Stefano Ministrini MD, PhD , Yustina M. Puspitasari MD, PhD , Georgia Beer MSc , Lena Schwarz MSc , Rebecca Niederberger MSc , Simon Kraler MD, PhD , Florian A. Wenzl MD , Mira Katan MD, PhD , Marco Bacigaluppi MD, PhD , Aurora Semerano MD , Alexander Akhmedov PhD , Susan Bengs PhD , Fabrizio Montecucco MD, PhD , Thomas F. Lüscher MD, PhD , Giovanni G. Camici PhD , Luca Liberale MD, PhD
{"title":"Endothelial JCAD Worsens Acute Ischemic Stroke Outcomes by Enhancing Inflammation in Response to Ischemia/Reperfusion","authors":"Stefano Ministrini MD, PhD ,&nbsp;Yustina M. Puspitasari MD, PhD ,&nbsp;Georgia Beer MSc ,&nbsp;Lena Schwarz MSc ,&nbsp;Rebecca Niederberger MSc ,&nbsp;Simon Kraler MD, PhD ,&nbsp;Florian A. Wenzl MD ,&nbsp;Mira Katan MD, PhD ,&nbsp;Marco Bacigaluppi MD, PhD ,&nbsp;Aurora Semerano MD ,&nbsp;Alexander Akhmedov PhD ,&nbsp;Susan Bengs PhD ,&nbsp;Fabrizio Montecucco MD, PhD ,&nbsp;Thomas F. Lüscher MD, PhD ,&nbsp;Giovanni G. Camici PhD ,&nbsp;Luca Liberale MD, PhD","doi":"10.1016/j.jacbts.2024.09.009","DOIUrl":"10.1016/j.jacbts.2024.09.009","url":null,"abstract":"<div><div>The role of junctional protein associated with coronary artery disease (JCAD) in acute ischemic stroke (AIS) has not been investigated yet. To investigate its potential as a therapeutic target, transient middle cerebral artery occlusion was induced in JCAD knockout mice, with improvement of stroke outcome and reduced blood-brain barrier permeability and expression of vascular cell adhesion molecule (VCAM)-1. JCAD plays a deleterious role in ischemia/reperfusion cerebral damage and associates with higher 90-day mortality in patients with AIS. JCAD may thus represent a novel prognostic biomarker for patients with AIS, as well as a therapeutic target.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 2","pages":"Pages 187-199"},"PeriodicalIF":8.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New GRK2 Inhibitor for Heart Failure
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-02-01 DOI: 10.1016/j.jacbts.2024.12.006
Chen Gao PhD , Ningjing Song PhD , Yibin Wang PhD
{"title":"A New GRK2 Inhibitor for Heart Failure","authors":"Chen Gao PhD ,&nbsp;Ningjing Song PhD ,&nbsp;Yibin Wang PhD","doi":"10.1016/j.jacbts.2024.12.006","DOIUrl":"10.1016/j.jacbts.2024.12.006","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 2","pages":"Pages 218-220"},"PeriodicalIF":8.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Art and Science of Communication in JACC: Basic to Translational Science
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-02-01 DOI: 10.1016/j.jacbts.2025.01.001
Douglas L. Mann MD (Editor-in-Chief, JACC: Basic to Translational Science)
{"title":"The Art and Science of Communication in JACC: Basic to Translational Science","authors":"Douglas L. Mann MD (Editor-in-Chief, JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2025.01.001","DOIUrl":"10.1016/j.jacbts.2025.01.001","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 2","pages":"Pages 242-246"},"PeriodicalIF":8.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional Testing of Familial Hypercholesterolemia-Related Variants
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-02-01 DOI: 10.1016/j.jacbts.2024.11.016
Marjorie H. Mizuta MD , Raul D. Santos MD, PhD, MSc
{"title":"Functional Testing of Familial Hypercholesterolemia-Related Variants","authors":"Marjorie H. Mizuta MD ,&nbsp;Raul D. Santos MD, PhD, MSc","doi":"10.1016/j.jacbts.2024.11.016","DOIUrl":"10.1016/j.jacbts.2024.11.016","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 2","pages":"Pages 184-186"},"PeriodicalIF":8.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stability of Ready-to-Use Solutions of Acetylcholine for Intracoronary Provocative Testing
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-01-01 DOI: 10.1016/j.jacbts.2024.09.010
Sylvia K. Neef PhD , Astrid Hubert PhD , Thomas E. Mürdter PhD , Peter Ong MD
{"title":"Stability of Ready-to-Use Solutions of Acetylcholine for Intracoronary Provocative Testing","authors":"Sylvia K. Neef PhD ,&nbsp;Astrid Hubert PhD ,&nbsp;Thomas E. Mürdter PhD ,&nbsp;Peter Ong MD","doi":"10.1016/j.jacbts.2024.09.010","DOIUrl":"10.1016/j.jacbts.2024.09.010","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 1","pages":"Pages 110-112"},"PeriodicalIF":8.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TIMD4hiMHCⅡhi Macrophages Preserve Heart Function Through Retnla
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-01-01 DOI: 10.1016/j.jacbts.2024.08.009
Danyang Zhang PhD , Xuanhao Wang PhD , Lianlian Zhu MS , Yuxing Chen PhD , Chao Yang PhD , Zhiwei Zhong MS , Xiangming Kong MS , Jinliang Nan PhD , Chen Wang PhD , Hengxun Hu PhD , Jinghai Chen PhD , Peng Shi PhD , Xinyang Hu MD, PhD , Wei Zhu PhD , Jian’an Wang MD, PhD
{"title":"TIMD4hiMHCⅡhi Macrophages Preserve Heart Function Through Retnla","authors":"Danyang Zhang PhD ,&nbsp;Xuanhao Wang PhD ,&nbsp;Lianlian Zhu MS ,&nbsp;Yuxing Chen PhD ,&nbsp;Chao Yang PhD ,&nbsp;Zhiwei Zhong MS ,&nbsp;Xiangming Kong MS ,&nbsp;Jinliang Nan PhD ,&nbsp;Chen Wang PhD ,&nbsp;Hengxun Hu PhD ,&nbsp;Jinghai Chen PhD ,&nbsp;Peng Shi PhD ,&nbsp;Xinyang Hu MD, PhD ,&nbsp;Wei Zhu PhD ,&nbsp;Jian’an Wang MD, PhD","doi":"10.1016/j.jacbts.2024.08.009","DOIUrl":"10.1016/j.jacbts.2024.08.009","url":null,"abstract":"<div><div>Genetic fate mapping confirmed the existence of the TIMD4<sup>hi</sup>MHCⅡ<sup>hi</sup> macrophage subset and showed that they were resident macrophages with minimal input from peripheral monocytes. Further, single-cell RNA sequencing revealed that <em>Retnla</em> could serve as the signature gene for TIMD4<sup>hi</sup>MHCⅡ<sup>hi</sup> macrophages. Administration of recombinant protein of the <em>Retnla</em> gene, RELMα, delayed the onset of heart failure, whereas either deletion of TIMD4<sup>hi</sup>MHCⅡ<sup>hi</sup> macrophages or macrophage-specific loss of <em>Retnla</em> facilitated heart failure progression.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 1","pages":"Pages 65-84"},"PeriodicalIF":8.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision Targeting of Cardiac Macrophage Subsets to Ameliorate Heart Failure
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-01-01 DOI: 10.1016/j.jacbts.2024.10.013
Connor Lantz PhD , Edward B. Thorp PhD
{"title":"Precision Targeting of Cardiac Macrophage Subsets to Ameliorate Heart Failure","authors":"Connor Lantz PhD ,&nbsp;Edward B. Thorp PhD","doi":"10.1016/j.jacbts.2024.10.013","DOIUrl":"10.1016/j.jacbts.2024.10.013","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 1","pages":"Pages 85-87"},"PeriodicalIF":8.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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