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JACC: Basic to Translational Science最新文献

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Exploring Cardiac Fibrosis 探索心脏纤维化
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-08-01 DOI: 10.1016/j.jacbts.2024.06.006
{"title":"Exploring Cardiac Fibrosis","authors":"","doi":"10.1016/j.jacbts.2024.06.006","DOIUrl":"10.1016/j.jacbts.2024.06.006","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002511/pdfft?md5=ecb69569eada2b1e5ced361205683ac9&pid=1-s2.0-S2452302X24002511-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognizing Early Career Translational Investigators 表彰早期职业转化研究人员
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-08-01 DOI: 10.1016/j.jacbts.2024.07.001
{"title":"Recognizing Early Career Translational Investigators","authors":"","doi":"10.1016/j.jacbts.2024.07.001","DOIUrl":"10.1016/j.jacbts.2024.07.001","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002559/pdfft?md5=62b9566391e44a42b2e7a00c62149ea9&pid=1-s2.0-S2452302X24002559-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Percutaneous LAAO and Pulsed-Field Isolation in a Canine Model 经皮 LAAO 和脉冲场隔离在犬模型中的应用
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-08-01 DOI: 10.1016/j.jacbts.2024.05.008
{"title":"Percutaneous LAAO and Pulsed-Field Isolation in a Canine Model","authors":"","doi":"10.1016/j.jacbts.2024.05.008","DOIUrl":"10.1016/j.jacbts.2024.05.008","url":null,"abstract":"<div><p>In this study, we investigated the feasibility, safety, and efficiency of using a novel device system to perform percutaneous left atrial appendage occlusion concomitant with left atrial appendage electrical isolation (LAAEI) via pulsed field ablation. In the acute phase, LAAEI was successful in 10 of 10 canines. At follow-up, full endothelialization was observed in 5 of 5 (100%) cases at 6 months. LAAEI was durable in 8 of 10 (80.00%) canines. Histologic examination in 4 of 6 LAAs with durable isolation showed transmural scars comprising fibrosis and fat. No pericardial effusion or phrenic paralysis was observed at follow-up. This preliminary study provides the scientific basis for first-in-human studies.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002158/pdfft?md5=bf8592b583224c93e5c2765c3e7770f5&pid=1-s2.0-S2452302X24002158-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Ex Vivo Model to Study Cardiac Fibrosis in Whole Mouse Hearts 研究小鼠全心心脏纤维化的新型体内外模型
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-08-01 DOI: 10.1016/j.jacbts.2024.04.007
{"title":"A New Ex Vivo Model to Study Cardiac Fibrosis in Whole Mouse Hearts","authors":"","doi":"10.1016/j.jacbts.2024.04.007","DOIUrl":"10.1016/j.jacbts.2024.04.007","url":null,"abstract":"<div><p>Fibrosis is a characteristic of many cardiac diseases for which no effective treatment exists. We have developed an ex vivo flow system, which allows induction of cardiac fibrosis in intact adult mouse hearts. Lineage-tracing studies indicated that the collagen-producing myofibroblasts originated from the resident fibroblasts. The extent of fibrosis was flow rate dependent, and pharmacological inhibition of the transforming growth factor beta signaling pathway prevented fibrosis. Therefore, in this powerful system, the cellular and molecular mechanisms underlying cardiac fibrosis can be studied. In addition, new targets can be tested on organ level for their ability to inhibit fibrosis.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24001761/pdfft?md5=dc7f3b5d33dd035f87483d2e94ca8a78&pid=1-s2.0-S2452302X24001761-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Empowering the Future: The Importance of Recognizing Early Career Scientists in JACC: Basic to Translational Science 为未来赋能：在《JACC.Basic to Translational Science》杂志上表彰早期职业科学家的重要性：从基础科学到转化科学
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-08-01 DOI: 10.1016/j.jacbts.2024.07.002
{"title":"Empowering the Future: The Importance of Recognizing Early Career Scientists in JACC: Basic to Translational Science","authors":"","doi":"10.1016/j.jacbts.2024.07.002","DOIUrl":"10.1016/j.jacbts.2024.07.002","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002572/pdfft?md5=036312729c00aed9480e98ea75b7b7b4&pid=1-s2.0-S2452302X24002572-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Clonal Hematopoiesis and Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy 克隆性造血与非缺血性扩张型心肌病左心室逆重塑之间的关系
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-08-01 DOI: 10.1016/j.jacbts.2024.04.010
{"title":"Association Between Clonal Hematopoiesis and Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy","authors":"","doi":"10.1016/j.jacbts.2024.04.010","DOIUrl":"10.1016/j.jacbts.2024.04.010","url":null,"abstract":"<div><p>Although clonal hematopoiesis of indeterminate potential (CHIP) is an adverse prognostic factor for atherosclerotic disease, its impact on nonischemic dilated cardiomyopathy (DCM) is elusive. The authors performed whole-exome sequencing and deep target sequencing among 198 patients with DCM and detected germline mutations in cardiomyopathy-related genes and somatic mutations in CHIP driver genes. Twenty-five CHIP driver mutations were detected in 22 patients with DCM. Ninety-two patients had cardiomyopathy-related pathogenic mutations. Multivariable analysis revealed that CHIP was an independent risk factor of left ventricular reverse remodeling, irrespective of known prognostic factors. CHIP exacerbated cardiac systolic dysfunction and fibrosis in a DCM murine model. The identification of germline and somatic mutations in patients with DCM predicts clinical prognosis.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24001839/pdfft?md5=cc874762764de0cd7d19f08b5f3343e6&pid=1-s2.0-S2452302X24001839-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141408407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduced Stroke Volume and Brain Perfusion Drive Postural Hyperventilation in Postural Orthostatic Tachycardia Syndrome 体位性正位性心动过速综合征患者脑卒中量减少和脑灌注减少驱动体位性过度换气
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-08-01 DOI: 10.1016/j.jacbts.2024.04.011
{"title":"Reduced Stroke Volume and Brain Perfusion Drive Postural Hyperventilation in Postural Orthostatic Tachycardia Syndrome","authors":"","doi":"10.1016/j.jacbts.2024.04.011","DOIUrl":"10.1016/j.jacbts.2024.04.011","url":null,"abstract":"<div><p>Postural hyperventilation has been implicated as a cause of postural orthostatic tachycardia syndrome (POTS), yet the precise mechanisms underlying the heightened breathing response remain unclear. This study challenges current hypotheses by revealing that exaggerated peripheral chemoreceptor activity is not the primary driver of postural hyperventilation. Instead, significant contributions from reduced stroke volume and compromised brain perfusion during orthostatic stress were identified. These findings shed light on our understanding of POTS pathophysiology, emphasizing the critical roles of systemic hemodynamic status. Further research should explore interventions targeting stroke volume and brain perfusion for more effective clinical management of POTS.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24001840/pdfft?md5=b5757b235b6cd1cded084a5319731689&pid=1-s2.0-S2452302X24001840-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LL-37: A Direct Link Between Inflammation and Myocardial Infarction LL-37：炎症与心肌梗死之间的直接联系
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-07-01 DOI: 10.1016/j.jacbts.2024.05.007
{"title":"LL-37: A Direct Link Between Inflammation and Myocardial Infarction","authors":"","doi":"10.1016/j.jacbts.2024.05.007","DOIUrl":"10.1016/j.jacbts.2024.05.007","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002146/pdfft?md5=97f15ae5ef87c5e122e74a9ea0adffe1&pid=1-s2.0-S2452302X24002146-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Pathway of Platelet Activation in ACS Mediated by LL-37 Immunoglobulin G Autoantibody Immune Complexes 由 LL-37 免疫球蛋白 G 自身抗体免疫复合物介导的 ACS 中血小板活化的新途径
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-07-01 DOI: 10.1016/j.jacbts.2024.04.012
{"title":"A Novel Pathway of Platelet Activation in ACS Mediated by LL-37 Immunoglobulin G Autoantibody Immune Complexes","authors":"","doi":"10.1016/j.jacbts.2024.04.012","DOIUrl":"10.1016/j.jacbts.2024.04.012","url":null,"abstract":"<div><p>The cathelicidin antimicrobial peptide LL-37 is a self-antigen in neutrophil extracellular traps that provokes autoantibody responses in autoimmune/autoinflammatory conditions. LL-37 immunoglobulin (Ig) G autoantibody levels were measured in subjects with and without atherosclerotic cardiovascular disease assessed using the coronary artery calcium score, in patients who had a future myocardial infarction and in a cohort of acute coronary syndrome (ACS) patients. LL-37 IgG levels were not associated with coronary artery calcium score, but future myocardial infarction patients had significantly higher LL-37 IgG at baseline. Reduced LL-37 IgG in ACS was associated with increased LL-37 IgG–immune complex. ACS plasma increased activated CD62P+ platelets from healthy donors mediated in part by LL-37 IgG–immune complexes and platelet Fc gamma receptor 2a.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24001852/pdfft?md5=a6e5c6a86e9151e8b8e985941cfea515&pid=1-s2.0-S2452302X24001852-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Aortic Stenotic Valve-Derived Extracellular Vesicles Induce Endothelial Dysfunction and Thrombogenicity Through AT1R/NADPH Oxidases/SGLT2 Pro-Oxidant Pathway 人主动脉瓣狭窄衍生的细胞外囊泡通过 AT1R/NADPH 氧化酶/SGLT2 促氧化剂途径诱导内皮功能障碍和血栓形成
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-07-01 DOI: 10.1016/j.jacbts.2024.02.012
{"title":"Human Aortic Stenotic Valve-Derived Extracellular Vesicles Induce Endothelial Dysfunction and Thrombogenicity Through AT1R/NADPH Oxidases/SGLT2 Pro-Oxidant Pathway","authors":"","doi":"10.1016/j.jacbts.2024.02.012","DOIUrl":"10.1016/j.jacbts.2024.02.012","url":null,"abstract":"<div><p>Pathological tissues release a variety of factors, including extracellular vesicles (EVs) shed by activated or apoptotic cells. EVs trapped within the native pathological valves may act as key mediators of valve thrombosis. Human aortic stenosis EVs promote activation of valvular endothelial cells, leading to endothelial dysfunction, and proadhesive and procoagulant responses.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24000901/pdfft?md5=01e109e05e1c49392f43b2d6319c6c96&pid=1-s2.0-S2452302X24000901-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141614402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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