JACC: Basic to Translational Science最新文献

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S2452-302X(26)00196-8","DOIUrl":"10.1016/S2452-302X(26)00196-8","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 8","pages":"Article 101673"},"PeriodicalIF":8.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148854350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PD-1/PD-L1 in Myocarditis","authors":"Vivek Durai MD, PhD, Javid J. Moslehi MD","doi":"10.1016/j.jacbts.2026.101569","DOIUrl":"10.1016/j.jacbts.2026.101569","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 8","pages":"Article 101569"},"PeriodicalIF":8.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognizing Early Career Translational Investigators","authors":"Matthias Nahrendorf MD (Editor-in-Chief: JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2026.101671","DOIUrl":"10.1016/j.jacbts.2026.101671","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 8","pages":"Article 101671"},"PeriodicalIF":8.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle Biofunctionalization of Bioprosthetic Heart Valves to Modulate Mechanisms of Structural Valve Deterioration","authors":"Angus J. Grant BSc,&nbsp;Alex H.P. Chan PhD,&nbsp;Xueying S. Xu BSc,&nbsp;Kieran Lau PhD,&nbsp;Timothy C. Mitchell PhD,&nbsp;Juichien Hung MSc,&nbsp;Praveesuda L. Michael PhD,&nbsp;Miguel Santos PhD,&nbsp;Aeryne Lee PhD,&nbsp;Jacopo Giaretta PhD,&nbsp;Tiffany Goh PhD,&nbsp;Chi-Hui Tsao MSc,&nbsp;Anna Waterhouse PhD,&nbsp;Sina Naficy PhD,&nbsp;Jelena Rnjak-Kovacina PhD,&nbsp;Martin K.C. Ng MD, PhD,&nbsp;Steven G. Wise PhD,&nbsp;Richard P. Tan PhD","doi":"10.1016/j.jacbts.2026.101641","DOIUrl":"10.1016/j.jacbts.2026.101641","url":null,"abstract":"<div><div>Bioprosthetic heart valves made from glutaraldehyde-fixed animal pericardium are widely used for valve replacement but are prone to early degeneration arising from the interplay of thrombosis, inflammation, and calcification. Current chemical treatments passivate the tissue surface but do not address these biological processes. This study introduces a plasma polymerized nanoparticle (PPN) platform that enables rapid, uniform coating of bioprosthetic pericardium and provides binding sites for active drug functionalization. Using PPNs, we immobilized the anticoagulant apixaban, the selective NLRP3-inflammasome inhibitor MCC950, or the anticalcification compound phytic acid directly onto valve tissue. These functionalized coatings reduced thrombosis in vitro and limited fibrosis and calcification in a 28-day rat subcutaneous model, demonstrating the capacity of PPNs to conjugate different small molecules to target multiple mechanisms of valve deterioration. Importantly, PPN coatings did not alter leaflet mechanics or hemodynamic performance when applied to a commercial transcatheter valve. This versatile coating platform represents an important advance in bioprosthetic valve technology with significant implications for their performance.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 8","pages":"Article 101641"},"PeriodicalIF":8.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian Randomization Reveals Interleukin-6 Receptor-Lipoprotein(a) Interplay With Independent Cardiovascular Risk Reductions","authors":"Azin Kheirkhah PhD,&nbsp;Silvia Di Maio PhD,&nbsp;Stefan Coassin PhD,&nbsp;Sebastian Schönherr PhD,&nbsp;Claudia Lamina PhD,&nbsp;Lukas Forer PhD,&nbsp;Florian Kronenberg MD,&nbsp;Johanna F. Schachtl-Riess PhD","doi":"10.1016/j.jacbts.2026.101564","DOIUrl":"10.1016/j.jacbts.2026.101564","url":null,"abstract":"<div><div>In the study at hand, 2-sample Mendelian randomization supported a causal effect of interleukin-6 receptor (IL-6R) signaling on Lp(a) concentrations, revealing a direct interplay between 2 causal risk factors for cardiovascular disease (CVD). Importantly, epidemiological analyses in UK Biobank showed that neglecting the IL-6R functional state can confound the association between IL-6 levels and Lp(a). However, the effect of circulating IL-6 on Lp(a) concentrations was modest even when the functional state of the receptor was considered. In line, factorial Mendelian randomization indicated that down-regulation of IL-6R signaling and Lp(a) independently reduce CVD risk, highlighting complementary opportunities for CVD risk mitigation.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 8","pages":"Article 101564"},"PeriodicalIF":8.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ECG as a Discovery Instrument for Sudden Cardiac Death","authors":"Matthias Nahrendorf MD, PhD (Editor-in-Chief, JACC: Basic to Translational Science),&nbsp;Aneesh Bapat MD (Associate Editor, JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2026.101656","DOIUrl":"10.1016/j.jacbts.2026.101656","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 8","pages":"Article 101656"},"PeriodicalIF":8.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Viral Trafficking to Immune Surveillance","authors":"Matthias Nahrendorf MD, PhD (Editor-in-Chief, JACC: Basic to Translational Science),&nbsp;Filip K. Swirski PhD","doi":"10.1016/j.jacbts.2026.101634","DOIUrl":"10.1016/j.jacbts.2026.101634","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 7","pages":"Article 101634"},"PeriodicalIF":8.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148603387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognizing Early Career Translational Investigators","authors":"Matthias Nahrendorf MD (Editor-in-Chief: JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2026.101638","DOIUrl":"10.1016/j.jacbts.2026.101638","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 7","pages":"Article 101638"},"PeriodicalIF":8.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148603384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RetiMap","authors":"Yeela Talmor-Barkan MD, PhD,&nbsp;Michal Shapira MSc,&nbsp;Smadar Shilo MD, PhD,&nbsp;Maria Gorodetski MSc,&nbsp;Dana Azouri PhD,&nbsp;Yaron Aviv MD,&nbsp;Yotam Reisner MD,&nbsp;Anastasia Godneva MSc,&nbsp;Adina Weinberger PhD,&nbsp;Alon Skaat MD,&nbsp;Anat Loewenstein MD,&nbsp;Eran Berkowitz MD,&nbsp;Ran Kornowski MD,&nbsp;Eran Segal PhD,&nbsp;Hagai Rossman PhD","doi":"10.1016/j.jacbts.2026.101596","DOIUrl":"10.1016/j.jacbts.2026.101596","url":null,"abstract":"<div><div>Fundus imaging enables noninvasive, high-resolution visualization of the retinal microvasculature. Advances in artificial intelligence (AI) now allow for extraction of quantitative vascular metrics from retinal images, offering new opportunities for identifying systemic health biomarkers. This study sought to characterize retinal microvascular features in a large healthy population and assess their associations with diverse clinical phenotypes and evaluate their ability to predict incident cardiovascular events. We analyzed fundus photographs from 8,467 healthy individuals aged 40-70 years enrolled in the Human Phenotype Project. For external validation we used fundus images from 16,249 participants from UK Biobank. Using an automated AI-based tool (AutoMorph), we extracted 12 quantitative vascular metrics, such as vessel density, average width, fractal dimension, distance tortuosity, and curvature tortuosity, separately for arteries and veins. We derived age- and sex-stratified reference values and evaluated associations with clinical parameters spanning cardiometabolic, respiratory, and behavioral domains. Retinal vascular features demonstrated strong age- and sex-related patterns. Multiple significant associations were observed between microvascular metrics and systemic traits. Arterial features were particularly associated with cardiometabolic factors including blood pressure, lipid profiles, glycemic indices, and body composition (body mass index, fat mass), as well as sleep apnea parameters. Findings replicated in UK Biobank and demonstrated prognostic value for incident cardiovascular events. This large-scale, AI-driven study provides normative data on retinal vascular traits and supports the utility of fundus imaging for systemic risk stratification and prediction of cardiovascular events. Our findings highlight the potential of retinal biomarkers for early detection and monitoring of cardiometabolic and sleep-related conditions, reinforcing the emerging role of oculomics in predictive and preventive health care.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 7","pages":"Article 101596"},"PeriodicalIF":8.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Metabolic-Inflammatory Axis in Hypertrophic Cardiomyopathy","authors":"Katharina J. Ermer MSc,&nbsp;Vasco Sequeira PhD","doi":"10.1016/j.jacbts.2026.101619","DOIUrl":"10.1016/j.jacbts.2026.101619","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 7","pages":"Article 101619"},"PeriodicalIF":8.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148603392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}