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Have Your Sodium-Glucose Cotransporter 2 Inhibitor–Derived Ketones and Eat Them Too
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2024.12.013
Virginia S. Hahn MD, Navid Koleini MD, PhD
{"title":"Have Your Sodium-Glucose Cotransporter 2 Inhibitor–Derived Ketones and Eat Them Too","authors":"Virginia S. Hahn MD, Navid Koleini MD, PhD","doi":"10.1016/j.jacbts.2024.12.013","DOIUrl":"10.1016/j.jacbts.2024.12.013","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 304-306"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First-in-Human Experience With a Biventricular, Pulsatile MCS Platform Technology Avoiding Blood Contact
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.01.017
Stephen Wildhirt MD , Arjang Ruhparwar MD , Stephan Schueler MD , Ulrich Stock MD , Jasmin S. Hanke MD , Jan D. Schmitto MD , Henning Pauli MD , Jan Karsten MD , Finn Gustafsson MD , Bastian Schmack MD
{"title":"First-in-Human Experience With a Biventricular, Pulsatile MCS Platform Technology Avoiding Blood Contact","authors":"Stephen Wildhirt MD , Arjang Ruhparwar MD , Stephan Schueler MD , Ulrich Stock MD , Jasmin S. Hanke MD , Jan D. Schmitto MD , Henning Pauli MD , Jan Karsten MD , Finn Gustafsson MD , Bastian Schmack MD","doi":"10.1016/j.jacbts.2025.01.017","DOIUrl":"10.1016/j.jacbts.2025.01.017","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 267-269"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Transaortic Pulsatile Pump to Unload the Left Ventricle
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.01.012
James Kim MD , Paula Rambarat MD , Allison Levin MD , Phillip C. Yang MD , Jeffrey Teuteberg MD , Arnold Seto MD, MPA , Morton Kern MD , Barry Greenberg MD , Manesh Patel MD , Marat Fudim MD
{"title":"A Novel Transaortic Pulsatile Pump to Unload the Left Ventricle","authors":"James Kim MD , Paula Rambarat MD , Allison Levin MD , Phillip C. Yang MD , Jeffrey Teuteberg MD , Arnold Seto MD, MPA , Morton Kern MD , Barry Greenberg MD , Manesh Patel MD , Marat Fudim MD","doi":"10.1016/j.jacbts.2025.01.012","DOIUrl":"10.1016/j.jacbts.2025.01.012","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 270-272"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI-Enabled Smartwatch ECG: A Feasibility Study for Early Prediction and Prevention of Heart Failure Rehospitalization
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.01.005
Hak Seung Lee MD , Sora Kang MS , Yong-Yeon Jo PhD , Jeong Min Son MD , Min Sung Lee MD, MS , Joon-myoung Kwon MD, MS , Kyung-Hee Kim MD, PhD
{"title":"AI-Enabled Smartwatch ECG: A Feasibility Study for Early Prediction and Prevention of Heart Failure Rehospitalization","authors":"Hak Seung Lee MD , Sora Kang MS , Yong-Yeon Jo PhD , Jeong Min Son MD , Min Sung Lee MD, MS , Joon-myoung Kwon MD, MS , Kyung-Hee Kim MD, PhD","doi":"10.1016/j.jacbts.2025.01.005","DOIUrl":"10.1016/j.jacbts.2025.01.005","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 250-252"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Homeostatic Role of Decorin in Right Ventricular Pressure Overload and Pulmonary Hypertension Induced Remodeling
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2024.10.007
Yohei Akazawa MD, PhD , Sriram Vaidyanathan PhD , Michael Bradley Dewar MSc , Kana Yazaki MD, PhD , John Dauz MSc , Osami Honjo MD, PhD , Mei Sun MD , Golam Kabir MD , Robert P. Jankov MD, PhD , Scott Patrick Heximer PhD , Kim A. Connelly MD, PhD , Mark K. Friedberg MD, PhD
{"title":"Homeostatic Role of Decorin in Right Ventricular Pressure Overload and Pulmonary Hypertension Induced Remodeling","authors":"Yohei Akazawa MD, PhD ,&nbsp;Sriram Vaidyanathan PhD ,&nbsp;Michael Bradley Dewar MSc ,&nbsp;Kana Yazaki MD, PhD ,&nbsp;John Dauz MSc ,&nbsp;Osami Honjo MD, PhD ,&nbsp;Mei Sun MD ,&nbsp;Golam Kabir MD ,&nbsp;Robert P. Jankov MD, PhD ,&nbsp;Scott Patrick Heximer PhD ,&nbsp;Kim A. Connelly MD, PhD ,&nbsp;Mark K. Friedberg MD, PhD","doi":"10.1016/j.jacbts.2024.10.007","DOIUrl":"10.1016/j.jacbts.2024.10.007","url":null,"abstract":"<div><div>Right ventricular (RV) pressure loading induces RV profibrotic signaling and fibrosis associated with RV dysfunction. RV decorin protein levels are decreased in patients with chronic RV pressure loading. RV decorin protein levels are also decreased in 4 animal models of mechanical RV pressure loading and pulmonary arterial hypertension. Human cardiac fibroblasts overexpressing decorin show diminished collagen-1 secretion in response to mechanical or chemical profibrotic stress while decorin knockout human cardiac fibroblasts show increased collagen-1 secretion in response to stress. Downregulation of decorin may play a key role in upregulating transforming growth factor-β1 profibrotic signaling and fibrosis that contribute to RV dysfunction in RV pressure loading.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 323-341"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implantable Cardiac Patch Continuously Monitors Acute Heart Failure Biomarkers In Vivo and Ex Vivo
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-03-01 DOI: 10.1016/j.jacbts.2025.01.011
Devleena Das PhD , Eric Rytkin PhD , Jagotamoy Das PhD , Jiangdong Deng PhD , Katy Trampel BS , Igor Efimov PhD , Shana Kelley PhD
{"title":"Implantable Cardiac Patch Continuously Monitors Acute Heart Failure Biomarkers In Vivo and Ex Vivo","authors":"Devleena Das PhD ,&nbsp;Eric Rytkin PhD ,&nbsp;Jagotamoy Das PhD ,&nbsp;Jiangdong Deng PhD ,&nbsp;Katy Trampel BS ,&nbsp;Igor Efimov PhD ,&nbsp;Shana Kelley PhD","doi":"10.1016/j.jacbts.2025.01.011","DOIUrl":"10.1016/j.jacbts.2025.01.011","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 3","pages":"Pages 273-275"},"PeriodicalIF":8.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143678411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed miR-199a Administration After Myocardial Infarction Precludes Pro-Regenerative Effects.
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-02-07 DOI: 10.1016/j.jacbts.2024.12.014
Gia Burjanadze, Nikoloz Gorgodze, Giovanni Donato Aquaro, Khatia Gabisonia, Lucia Carlucci, Manendra Pachauri, Federico Turreni, Ilaria Secco, Fabio Bernini, Lorena Zentilin, Mauro Giacca, Fabio A Recchia
{"title":"Delayed miR-199a Administration After Myocardial Infarction Precludes Pro-Regenerative Effects.","authors":"Gia Burjanadze, Nikoloz Gorgodze, Giovanni Donato Aquaro, Khatia Gabisonia, Lucia Carlucci, Manendra Pachauri, Federico Turreni, Ilaria Secco, Fabio Bernini, Lorena Zentilin, Mauro Giacca, Fabio A Recchia","doi":"10.1016/j.jacbts.2024.12.014","DOIUrl":"https://doi.org/10.1016/j.jacbts.2024.12.014","url":null,"abstract":"<p><p>miR-199a carried by adeno-associated virus serotype 6 (AAV6) proved cardioreparative in a pig model when administered early after myocardial infarction (MI). To test whether the therapeutic efficacy of miR-199a is maintained when its administration is delayed, AAV6-miR-199a or a control AAV6 were injected 1 or 2 weeks after MI. Scar mass and cardiac contractile performance parameters were not significantly different between AAV6-miR-199a-treated and AAV6-control pigs. Nonetheless, most AAV6-miR-199a-treated pigs died from sudden death at 40 to 52 days after vector administration. For clinical translation, it appears mandatory to administer miR-199a early after MI and through modalities other than permanent expression from a viral vector.</p>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CXC-Chemokine-Receptor-Type-5 Expression on Circulating Naive B Cells Predicts Improvement After Cardiac Resynchronization Therapy
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-02-01 DOI: 10.1016/j.jacbts.2024.09.011
Kenneth C. Bilchick MD, MS , Jesse D. Cochran BS , Chantel McSkimming BS, Hema Kothari PhD, Zhaoxia Ma MS, Derek J. Bivona PhD, Stefan Bekiranov PhD, Coleen McNamara MD
{"title":"CXC-Chemokine-Receptor-Type-5 Expression on Circulating Naive B Cells Predicts Improvement After Cardiac Resynchronization Therapy","authors":"Kenneth C. Bilchick MD, MS ,&nbsp;Jesse D. Cochran BS ,&nbsp;Chantel McSkimming BS,&nbsp;Hema Kothari PhD,&nbsp;Zhaoxia Ma MS,&nbsp;Derek J. Bivona PhD,&nbsp;Stefan Bekiranov PhD,&nbsp;Coleen McNamara MD","doi":"10.1016/j.jacbts.2024.09.011","DOIUrl":"10.1016/j.jacbts.2024.09.011","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 2","pages":"Pages 221-223"},"PeriodicalIF":8.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognizing Early Career Translational Investigators
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-02-01 DOI: 10.1016/j.jacbts.2025.01.002
Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)
{"title":"Recognizing Early Career Translational Investigators","authors":"Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2025.01.002","DOIUrl":"10.1016/j.jacbts.2025.01.002","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 2","pages":"Page 241"},"PeriodicalIF":8.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large-Scale Functional Characterization of Low-Density Lipoprotein Receptor Gene Variants Improves Risk Assessment in Cardiovascular Disease
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2025-02-01 DOI: 10.1016/j.jacbts.2024.10.006
Mohammad Majharul Islam MSc , Max Tamlander MD , Iryna Hlushchenko PhD , Samuli Ripatti PhD , Simon G. Pfisterer PhD
{"title":"Large-Scale Functional Characterization of Low-Density Lipoprotein Receptor Gene Variants Improves Risk Assessment in Cardiovascular Disease","authors":"Mohammad Majharul Islam MSc ,&nbsp;Max Tamlander MD ,&nbsp;Iryna Hlushchenko PhD ,&nbsp;Samuli Ripatti PhD ,&nbsp;Simon G. Pfisterer PhD","doi":"10.1016/j.jacbts.2024.10.006","DOIUrl":"10.1016/j.jacbts.2024.10.006","url":null,"abstract":"<div><div>Limited access to functional information of genetic variants reduces the applicability of genetic tools for precision medicine applications in cardiovascular disease. We established an automated analysis platform based on multiplexed high-content imaging and derived in-depth functional data for several hundred <em>LDLR</em> gene variants. Residual low-density lipoprotein receptor activity of genetic variants impacted the risk for cardiovascular disease and elevated low-density lipoprotein cholesterol as well as the utilization of lipid-lowering and combination therapy. This enables increased risk stratification for carriers of <em>LDLR</em> gene variants and opens up new opportunities for improved diagnosis, risk assessment, and treatment selection in familial hypercholesterolemia.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 2","pages":"Pages 170-183"},"PeriodicalIF":8.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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