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The Technique of Permanent Pericardial Catheter in Mice 小鼠永久性心包导管技术
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-10-01 DOI: 10.1016/j.jacbts.2024.05.015
Vitali Rusinkevich MD, MS, PhD , David Elias BS , Monica Vladut Talor MSc , Daniela Čiháková MD, PhD
{"title":"The Technique of Permanent Pericardial Catheter in Mice","authors":"Vitali Rusinkevich MD, MS, PhD ,&nbsp;David Elias BS ,&nbsp;Monica Vladut Talor MSc ,&nbsp;Daniela Čiháková MD, PhD","doi":"10.1016/j.jacbts.2024.05.015","DOIUrl":"10.1016/j.jacbts.2024.05.015","url":null,"abstract":"<div><div>Intrapericardial delivery offers a route for heart therapies. Mouse heart size and membrane thickness pose catheterization challenges, hampering pericardium-targeted treatments. The objectives were to develop a mouse surgical technique for pericardial catheter insertion and to assess its suitability for intrapericardial delivery, including use with a myocardial ischemia/reperfusion model. We used successful catheter implantation in BALB/cJ and ΔdblGATA1 mice, showcasing intrapericardial delivery with fluorescent beads and eosinophils. We demonstrated a combination of pericardial catheterization with myocardial ischemia/reperfusion model. A reliable catheterization technique, enabling intrapericardial delivery of therapeutic agents in mice provides a valuable tool for studying the pericardial space and mediastinum in basic and translational research.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 10","pages":"Pages 1234-1247"},"PeriodicalIF":8.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognizing Early Career Translational Investigators 表彰早期职业转化研究人员
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-10-01 DOI: 10.1016/j.jacbts.2024.09.001
Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)
{"title":"Recognizing Early Career Translational Investigators","authors":"Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2024.09.001","DOIUrl":"10.1016/j.jacbts.2024.09.001","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 10","pages":"Pages 1264-1265"},"PeriodicalIF":8.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viewing Pulmonary Arterial Hypertension Pathogenesis and Opportunities for Disease-Modifying Therapy Through the Lens of Biomass 从生物质角度看肺动脉高压发病机制和疾病调节疗法的机遇
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-10-01 DOI: 10.1016/j.jacbts.2024.04.009
Matthew L. Steinhauser MD , Bradley A. Maron MD
{"title":"Viewing Pulmonary Arterial Hypertension Pathogenesis and Opportunities for Disease-Modifying Therapy Through the Lens of Biomass","authors":"Matthew L. Steinhauser MD ,&nbsp;Bradley A. Maron MD","doi":"10.1016/j.jacbts.2024.04.009","DOIUrl":"10.1016/j.jacbts.2024.04.009","url":null,"abstract":"<div><div>Fibroproliferative remodeling of distal pulmonary arterioles is a cornerstone characteristic of pulmonary arterial hypertension (PAH). Data from contemporary quantitative imaging suggest that anabolic synthesis of macromolecular substrate, defined here as <em>biomass</em>, is the proximate event that causes vascular remodeling via pathogenic changes to DNA, collagen, cytoskeleton, and lipid membranes. Modifying biomass is achievable but requires tilting the balance in favor of endogenous degradation over synthetic pathways in order to advance the first-ever disease-modifying PAH pharmacotherapy. Viewing PAH pathobiology through the lens of biomass represents an opportunity to decipher novel determinants of disease inception and inform interventions that induce reverse remodeling.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 10","pages":"Pages 1252-1263"},"PeriodicalIF":8.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141709733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia PCSK9 抗体治疗特异性地增强了杂合子家族性高胆固醇血症患者巨噬细胞特异性胆固醇逆向转运途径的功能
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-10-01 DOI: 10.1016/j.jacbts.2024.06.008
Carla Borràs MSc , Marina Canyelles PhD , Josefa Girona PhD , Daiana Ibarretxe MD, PhD , David Santos BS , Giovanna Revilla PhD , Vicenta Llorente-Cortes PhD , Noemí Rotllan PhD , Petri T. Kovanen MD, PhD , Matti Jauhiainen PhD , Miriam Lee-Rueckert PhD , Luis Masana MD, PhD , Francisco Arrieta MD, PhD , Javier Martínez-Botas PhD , Diego Gómez-Coronado PhD , Josep Ribalta PhD , Mireia Tondo PhD , Francisco Blanco-Vaca MD, PhD , Joan Carles Escolà-Gil PhD
{"title":"PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia","authors":"Carla Borràs MSc ,&nbsp;Marina Canyelles PhD ,&nbsp;Josefa Girona PhD ,&nbsp;Daiana Ibarretxe MD, PhD ,&nbsp;David Santos BS ,&nbsp;Giovanna Revilla PhD ,&nbsp;Vicenta Llorente-Cortes PhD ,&nbsp;Noemí Rotllan PhD ,&nbsp;Petri T. Kovanen MD, PhD ,&nbsp;Matti Jauhiainen PhD ,&nbsp;Miriam Lee-Rueckert PhD ,&nbsp;Luis Masana MD, PhD ,&nbsp;Francisco Arrieta MD, PhD ,&nbsp;Javier Martínez-Botas PhD ,&nbsp;Diego Gómez-Coronado PhD ,&nbsp;Josep Ribalta PhD ,&nbsp;Mireia Tondo PhD ,&nbsp;Francisco Blanco-Vaca MD, PhD ,&nbsp;Joan Carles Escolà-Gil PhD","doi":"10.1016/j.jacbts.2024.06.008","DOIUrl":"10.1016/j.jacbts.2024.06.008","url":null,"abstract":"<div><div>We investigated the potential of proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies to restore macrophage cholesterol efflux in subjects with heterozygous familial hypercholesterolemia (FH) and to enhance the macrophage-specific reverse cholesterol transport pathway in mice. Analyses of macrophage-derived cholesterol distribution of plasma from FH patients revealed that low-density lipoprotein (LDL) particles contained less, and high-density lipoprotein particles contained more radiolabeled cholesterol after treatment with either PCSK9 inhibitor. PCSK9 antibodies facilitated the transfer of macrophage-derived cholesterol and LDL-derived cholesterol to feces exclusively in heterozygous LDL receptor-deficient mice expressing human APOB100. PCSK9 inhibitors act as positive regulators of the macrophage-specific reverse cholesterol transport pathway in individuals with heterozygous FH.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 10","pages":"Pages 1195-1210"},"PeriodicalIF":8.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure-Based Probe Reveals the Presence of Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients 基于结构的探针揭示了 ATTR 淀粉样变性患者血浆中存在大量的转甲状腺素聚集体
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.05.013
Rose Pedretti BS , Lanie Wang BS , Anna Yakubovska MS , Qiongfang S. Zhang BS , Binh Nguyen PhD , Justin L. Grodin MD , Ahmad Masri MD , Lorena Saelices PhD
{"title":"Structure-Based Probe Reveals the Presence of Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients","authors":"Rose Pedretti BS ,&nbsp;Lanie Wang BS ,&nbsp;Anna Yakubovska MS ,&nbsp;Qiongfang S. Zhang BS ,&nbsp;Binh Nguyen PhD ,&nbsp;Justin L. Grodin MD ,&nbsp;Ahmad Masri MD ,&nbsp;Lorena Saelices PhD","doi":"10.1016/j.jacbts.2024.05.013","DOIUrl":"10.1016/j.jacbts.2024.05.013","url":null,"abstract":"<div><div>Amyloidogenic transthyretin (ATTR) amyloidosis is a relentlessly progressive disease caused by the misfolding and systemic accumulation of amyloidogenic transthyretin into amyloid fibrils. These fibrils cause diverse clinical phenotypes, mainly cardiomyopathy and/or polyneuropathy. Little is known about the aggregation of transthyretin during disease development and whether this has implications for diagnosis and treatment. Using the cryogenic electron microscopy structures of mature ATTR fibrils, we developed a peptide probe for fibril detection. With this probe, we have identified previously unknown aggregated transthyretin species in plasma of patients with ATTR amyloidosis. These species are large, non-native, and distinct from monomeric and tetrameric transthyretin. Observations from our study open many questions about the biology of ATTR amyloidosis and reveal a potential diagnostic and therapeutic target.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 9","pages":"Pages 1088-1100"},"PeriodicalIF":8.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002201/pdfft?md5=5b6a105e3917c13332161203cd4e2112&pid=1-s2.0-S2452302X24002201-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognizing Early Career Translational Investigators 表彰早期职业转化研究人员
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.07.010
Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)
{"title":"Recognizing Early Career Translational Investigators","authors":"Douglas L. Mann MD (Editor-in-Chief: JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2024.07.010","DOIUrl":"10.1016/j.jacbts.2024.07.010","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 9","pages":"Page 1162"},"PeriodicalIF":8.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002900/pdfft?md5=1141885f18877b300920fcb40d32afd6&pid=1-s2.0-S2452302X24002900-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients ATTR 淀粉样变性患者血浆中的大颗粒转甲状腺素聚集体
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.07.005
Marianna Fontana MD, PhD, Julian D. Gillmore MD, PhD, Guglielmo Verona PhD
{"title":"Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients","authors":"Marianna Fontana MD, PhD,&nbsp;Julian D. Gillmore MD, PhD,&nbsp;Guglielmo Verona PhD","doi":"10.1016/j.jacbts.2024.07.005","DOIUrl":"10.1016/j.jacbts.2024.07.005","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 9","pages":"Pages 1101-1103"},"PeriodicalIF":8.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002626/pdfft?md5=e77b10104ae3c22d7d1194e17b18a735&pid=1-s2.0-S2452302X24002626-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TRIM55 Aggravates Cardiomyocyte Apoptosis After Myocardial Infarction via Modulation of the Nrf2/HO-1 Pathway TRIM55 通过调节 Nrf2/HO-1 通路加剧心肌梗死后的心肌细胞凋亡
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.05.006
Yuxin Bu MM , Yanxia Liu MD , Meili Liu MD, Chenghui Yan MD, Jing Wang MM, Hanlin Wu MM, Haixu Song MD, Dali Zhang MD, Kai Xu MD, Dan Liu MD, Yaling Han MD, PhD
{"title":"TRIM55 Aggravates Cardiomyocyte Apoptosis After Myocardial Infarction via Modulation of the Nrf2/HO-1 Pathway","authors":"Yuxin Bu MM ,&nbsp;Yanxia Liu MD ,&nbsp;Meili Liu MD,&nbsp;Chenghui Yan MD,&nbsp;Jing Wang MM,&nbsp;Hanlin Wu MM,&nbsp;Haixu Song MD,&nbsp;Dali Zhang MD,&nbsp;Kai Xu MD,&nbsp;Dan Liu MD,&nbsp;Yaling Han MD, PhD","doi":"10.1016/j.jacbts.2024.05.006","DOIUrl":"10.1016/j.jacbts.2024.05.006","url":null,"abstract":"<div><div>Tripartite motif-containing 55 (Trim55) is mainly expressed in myocardium and skeletal muscle, which plays an important role in promoting the embryonic development of the mouse heart. We investigated the role of Trim55 in myocardial infarction and the associated molecular mechanisms. We studied both gain and loss of function in vivo and in vitro. The results showed that Trim55 knockout improved cardiac function and apoptosis after myocardial infarction, and overexpression aggravated cardiac function damage. The mechanism is that Trim55 interacts with nuclear factor, erythroid derived 2 (Nrf2) to accelerate its degradation and inhibit the expression of heme oxygenase 1, thereby promoting cardiomyocyte apoptosis.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 9","pages":"Pages 1104-1122"},"PeriodicalIF":8.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002134/pdfft?md5=017379718d1c2bd24f63c67d39e1d9dd&pid=1-s2.0-S2452302X24002134-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interferon Interrupted 干扰素中断
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.06.011
Harvey G. Roweth PhD
{"title":"Interferon Interrupted","authors":"Harvey G. Roweth PhD","doi":"10.1016/j.jacbts.2024.06.011","DOIUrl":"10.1016/j.jacbts.2024.06.011","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 9","pages":"Pages 1141-1143"},"PeriodicalIF":8.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002584/pdfft?md5=86065a350c4da9c923fbf43df31edbe8&pid=1-s2.0-S2452302X24002584-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibiting the P2Y12 Receptor in Megakaryocytes and Platelets Suppresses Interferon-Associated Responses 抑制巨核细胞和血小板中的 P2Y12 受体可抑制干扰素相关反应
IF 8.4 1区 医学
JACC: Basic to Translational Science Pub Date : 2024-09-01 DOI: 10.1016/j.jacbts.2024.05.014
Marcin A. Sowa PhD , Haoyu Sun PhD , Tricia T. Wang BA , Vitor W. Virginio PhD , Florencia Schlamp PhD , Hanane El Bannoudi PhD , MacIntosh Cornwell PhD , Hannah Bash BA , Peter M. Izmirly MD , H. Michael Belmont MD , Kelly V. Ruggles PhD , Jill P. Buyon MD , Deepak Voora MD , Tessa J. Barrett PhD , Jeffrey S. Berger MD
{"title":"Inhibiting the P2Y12 Receptor in Megakaryocytes and Platelets Suppresses Interferon-Associated Responses","authors":"Marcin A. Sowa PhD ,&nbsp;Haoyu Sun PhD ,&nbsp;Tricia T. Wang BA ,&nbsp;Vitor W. Virginio PhD ,&nbsp;Florencia Schlamp PhD ,&nbsp;Hanane El Bannoudi PhD ,&nbsp;MacIntosh Cornwell PhD ,&nbsp;Hannah Bash BA ,&nbsp;Peter M. Izmirly MD ,&nbsp;H. Michael Belmont MD ,&nbsp;Kelly V. Ruggles PhD ,&nbsp;Jill P. Buyon MD ,&nbsp;Deepak Voora MD ,&nbsp;Tessa J. Barrett PhD ,&nbsp;Jeffrey S. Berger MD","doi":"10.1016/j.jacbts.2024.05.014","DOIUrl":"10.1016/j.jacbts.2024.05.014","url":null,"abstract":"<div><div>The authors investigated the impact of antiplatelet therapy on the megakaryocyte (MK) and platelet transcriptome. RNA-sequencing was performed on MKs treated with aspirin or P2Y<sub>12</sub> inhibitor, platelets from healthy volunteers receiving aspirin or P2Y<sub>12</sub> inhibition, and platelets from patients with systemic lupus erythematosus (SLE). P2Y<sub>12</sub> inhibition reduced gene expression and inflammatory pathways in MKs and platelets. In SLE, the interferon (IFN) pathway was elevated. In vitro experiments demonstrated the role of P2Y<sub>12</sub> inhibition in reducing IFNα-induced platelet-leukocyte interactions and IFN signaling pathways. These results suggest that P2Y<sub>12</sub> inhibition may have therapeutic potential for proinflammatory and autoimmune conditions like SLE.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 9","pages":"Pages 1126-1140"},"PeriodicalIF":8.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24002213/pdfft?md5=7f2c6a99acc7a7dc4600a00905868755&pid=1-s2.0-S2452302X24002213-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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