心脏TRPM7导致糖尿病性心力衰竭并保留射血分数

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2025-08-01 DOI:10.1016/j.jacbts.2025.101321

Man Liu PhD, Hong Liu MD, PhD, Gyeoung-Jin Kang PhD, Lynn M. Hartweck PhD, Feng Feng BS, Eunji Kim PhD, Kurt W. Prins MD, PhD, Samuel C. Dudley Jr. MD, PhD

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引用次数: 0

摘要

低镁血症（HypoMg）和随后的氧化应激导致糖尿病心脏舒张功能障碍和心力衰竭并保留射血分数。一种具有通道和激酶功能的Mg2+转运体，瞬时受体电位阳离子通道亚家族m7 (TRPM7)，在HypoMg中上调。糖尿病小鼠有HypoMg和心脏TRPM7表达升高。TRPM7激酶介导的HypoMg线粒体功能障碍和心脏舒张功能障碍。TRPM7激酶增强线粒体Fgr表达，导致复合体II功能障碍和线粒体活性氧过量产生。抑制TRPM7激酶代表了保留射血分数治疗糖尿病性心力衰竭的潜在新治疗策略。

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Cardiac TRPM7 Causes Diabetic Heart Failure With Preserved Ejection Fraction

Hypomagnesemia (HypoMg) and subsequent oxidative stress cause diabetic cardiac diastolic dysfunction and heart failure with preserved ejection fraction. A Mg²⁺ transporter with channel and kinase function, transient receptor potential cation channel subfamily M 7 (TRPM7), is upregulated in HypoMg. Diabetes mellitus mice had HypoMg and elevated TRPM7 expression in the heart. TRPM7 kinase mediated mitochondrial dysfunction and cardiac diastolic dysfunction in HypoMg. TRPM7 kinase enhanced mitochondrial Fgr expression, with subsequent complex II dysfunction and mitochondrial reactive oxygen species overproduction. Inhibition of TRPM7 kinase represents a potential novel therapeutic strategy to treat diabetic heart failure with preserved ejection fraction.

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.