次黄嘌呤促进肺血管重构和腺苷脱氨酶是肺动脉高压的治疗靶点

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2025-08-01 DOI:10.1016/j.jacbts.2025.03.005

Jun-Zhuo Shi MS , Yong-Jian Zhu MD , Meng-Jie Zhang BS , Yi Yan PhD , Lu-Ling Zhao MS , Hong-Da Zhang MD , Yan Liu MD , Wen-Hui Wu PhD , Zhe Cheng MD , Chun-Guang Qiu MD , Jie-Jian Kou MS , Yun-Feng Zhou PhD , Xiao-Bin Pang PhD , Ji-Wang Chen MD , Xin-Mei Xie MS , Yang-Yang He PhD , Zhi-Cheng Jing MD

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引用次数: 0

摘要

尿酸代谢与肺动脉高压的发病机制有关，其中关键代谢物次黄嘌呤水平升高，从而通过促进细胞增殖和迁移以及调节三磷酸腺苷结合盒运输信号通路促进肺血管重构。因此，针对次黄嘌呤合成的治疗干预措施可能对肺动脉高压的治疗有希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hypoxanthine Promotes Pulmonary Vascular Remodeling and Adenosine Deaminase Is a Therapeutic Target for Pulmonary Hypertension

Uric acid metabolism is implicated in the pathogenesis of pulmonary arterial hypertension, wherein the key metabolite hypoxanthine exhibits elevated levels, thereby promoting pulmonary vascular remodeling through facilitation of cell proliferation and migration as well as regulation of adenosine triphosphate binding cassette transport signaling pathway. Consequently, therapeutic interventions targeting hypoxanthine synthesis may hold promise for the management of pulmonary arterial hypertension.

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.