c-FLIP通过fundc1介导的线粒体自噬调节来保护败血症诱导的心肌功能障碍中的心脏微循环。

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2025-08-01 DOI:10.1016/j.jacbts.2025.02.016

Lan Gao PhD , Qindong Shi PhD , Bin Sun MD , Xiaoyu Zhang MD , Peiying Zheng MD , Linjing Zhou MD , Gang Tian PhD , Hao Li PhD

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引用次数: 0

摘要

本研究探讨c-FLIP在脓毒症诱导心肌功能障碍（SIMD）中的作用，重点关注心脏微循环和线粒体自噬。通过SIMD大鼠和lps诱导的心脏微血管内皮细胞损伤模型，我们发现c-FLIP缺陷会破坏线粒体稳态，加剧微循环损伤。c-FLIP通过FUNDC1差异调控线粒体自噬。c-FLIP的过表达平衡自噬，保护线粒体，减少炎症，改善SIMD，突出了其作为治疗靶点的潜力。

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c-FLIP Protects Cardiac Microcirculation in Sepsis-Induced Myocardial Dysfunction Via FUNDC1-Mediated Regulation of Mitochondrial Autophagy

This study investigates the role of c-FLIP in sepsis-induced myocardial dysfunction (SIMD), focusing on cardiac microcirculation and mitochondrial autophagy. Using SIMD rat and LPS-induced cardiac microvascular endothelial cell injury models, we found that c-FLIP deficiency disrupts mitochondrial homeostasis, exacerbating microcirculatory damage. c-FLIP differentially regulates mitochondrial autophagy via FUNDC1. Overexpression of c-FLIP balances autophagy, protects mitochondria, reduces inflammation, and ameliorates SIMD, highlighting its potential as a therapeutic target.

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.