Journal of adolescent and young adult oncology最新文献

{"title":"Closing the Gap: The Need for Fertility Intervention for Young Adult Cancer Survivors.","authors":"Peyton R McDuffee, Molin Shi, Alexandra M Dunker, Emily J Smith, Nathan M Overholt, Sarah E Taghavi, Rebecca Eary, Brittany C Hall","doi":"10.1089/jayao.2024.0126","DOIUrl":"10.1089/jayao.2024.0126","url":null,"abstract":"<p><p>The current study identified the fertility-related needs of young adult (YA; ages 19-39) survivors. Participants (<i>n</i> = 94) completed the Adolescent and Young Adult Survivorship Psycho-Oncology Screening Tool-a screening tool developed to assess cancer-related concerns of YAs in survivorship. Approximately one-third of survivors endorsed fertility-related concerns. Frequency of fertility-related concerns was endorsed in descending order: \"not knowing fertility status/options,\" \"cost of fertility treatment,\" \"discussing fertility with others,\" and \"grief over fertility.\" Relationship between fertility concerns and other commonly reported survivorship concerns was identified. Findings highlight a gap in care for fertility-related needs in post-treatment survivorship care for YAs.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"378-382"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives on Care Plans for Adolescent and Young Adult Survivors of Childhood Cancer: A Qualitative Evaluation of Survivors, Caregivers, and Oncology and Primary Care Practitioners.","authors":"Katie Darabos, Janet A Deatrick, Courtney Benjamin Wolk, Bridget O'Hagan, Sara King-Dowling, Dava Szalda, Wendy Hobbie, Lamia P Barakat, Christine Hill-Kayser, Lisa A Schwartz","doi":"10.1177/21565333251362113","DOIUrl":"https://doi.org/10.1177/21565333251362113","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Treatment advances have led to a rapidly growing population of adolescent and young adult (AYA, ages 15-29) survivors of childhood cancer. Despite cure, AYA are physically and psychologically vulnerable due to treatment toxicity, leading 70% to develop second cancers or chronic, often life-threatening, late effects. Self-management is critical for survivorship and includes lifelong follow-up care, health promotion, disease surveillance, and management of late effects. Survivorship care plans (SCPs) are documents to inform survivors and providers of recommendations for management of survivor health and to improve communication among providers. With limited SCP research to date, there are calls for rigorous research to understand SCP implementation. <b><i>Methods:</i></b> Qualitative semistructured interviews were conducted to assess perceptions about SCPs, including barriers and facilitators of SCP implementation among 12 purposefully sampled AYAs who received an SCP in the extant trial, 8 caregivers of AYA, 10 oncology providers, and 8 pediatric primary care providers. <b><i>Results:</i></b> Overall, SCPs were viewed as generally positive by AYA and caregivers, with caveats about ways to improve them or use them. Oncology providers also generally had a positive view of the SCP, but primary care practitioners found them to be less targeted to their specific needs. <b><i>Conclusion:</i></b> Our results helped to clarify critical aspects of implementation that need to be addressed if SCPs are to be successfully implemented into survivorship care for AYA, especially as they transition to adult-oriented health care.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Children's Oncology Group Survey Exploring Practices and Barriers to Sperm Banking for Post-Pubertal Males with Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia.","authors":"Jessica L Feuerstein, Burton Appel","doi":"10.1177/21565333251364084","DOIUrl":"https://doi.org/10.1177/21565333251364084","url":null,"abstract":"<p><p>This study examined sperm banking (SB) practices and barriers for post-pubertal males with high-risk acute lymphoblastic leukemia (ALL) prior to chemotherapy. A cross-sectional survey of 2345 Children's Oncology Group oncologists across the U.S., Canada, Australia, and New Zealand yielded 572 responses. While 78% offer SB, common barriers include timing (70%) and patient health (44%). Most institutions offering SB have a dedicated oncofertility team (57%), and 86% are medium- or large-sized, suggesting greater resource availability. These results extend prior research by identifying actionable barriers and informing targeted interventions to improve access to FP for post-pubertal males with ALL.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Screening Uptake and Usual Source of Care Among Hispanic Survivors of Adolescent and Young Adult Cancer.","authors":"Eunju Choi, Amy M Berkman, Clark R Andersen, John M Salsman, Andrea C Betts, Joel Milam, Kimberly A Miller, Susan K Peterson, Qian Lu, Christabel K Cheung, Lauren V Ghazal, J A Livingston, Michelle A T Hildebrandt, Susan K Parsons, David R Freyer, Michael E Roth","doi":"10.1177/21565333251361619","DOIUrl":"https://doi.org/10.1177/21565333251361619","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> This study examines cancer screening rates and the usual source of care among Hispanic survivors of adolescent and young adult (AYA, aged 15-39) cancer, a group at increased risk for poor health outcomes, including secondary cancers. <b><i>Methods:</i></b> National Health Interview Survey data were analyzed to identify Hispanic survivors of AYA cancer and Hispanic age- and sex-matched non-cancer controls. Breast, cervical, and colorectal screening (ever screened and up-to-date according to the U.S. Preventive Services Task Force recommendations) as well as reporting a usual source of care were compared among survivors and controls eligible for screening using multivariable logistic regressions. <b><i>Results:</i></b> Hispanic survivors were significantly more likely than Hispanic controls to report up-to-date cervical (43.8% vs. 25.5%, <i>p</i> < 0.001) and colorectal (43.1% vs. 21.8%, <i>p</i> = 0.002) cancer screenings. Eligible female survivors were also significantly more likely than controls to report ever having been screened for breast (86.9% vs. 60.6%, <i>p</i> < 0.001) and cervical (43.3% vs. 17.2%, <i>p</i> < 0.001) cancers. Additionally, survivors were significantly more likely than controls to report a usual source of care (74.4% vs. 49.9%, <i>p</i> < 0.001). <b><i>Conclusion:</i></b> Although Hispanic survivors of AYA cancers were more likely than Hispanic individuals without a history of cancer to report up-to-date cancer screening, screening rates among both groups remain low. Notably, approximately one-quarter of survivors reported lacking a usual source of care, indicating potential gaps in preventive health care access. The findings highlight the need for targeted interventions to improve cancer screening uptake among Hispanic survivors of AYA cancer.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The UNI-AJA Project: A Feasibility Study Based on Real-World Data in French Adolescents and Young Adults with Cancer.","authors":"Emmanuel Desandes, Alizée Diatchenko, Hugo Crochet, Nicolas André, Jean-Yves Blay, Nathalie Gaspar, Lionnel Geoffrois, Sabine Heinrich, Pierre Kubicek, Valérie Laurence, Pierre Leblond, Cyril Lervat, Lise Molimard, Marilyne Poirée, Marion Salomon, Jill Serre, Maud Toulmonde, Pascale Varlet, Thierry Durand, Françoise Ducimetière, Perrine Marec-Berard","doi":"10.1177/21565333251359614","DOIUrl":"https://doi.org/10.1177/21565333251359614","url":null,"abstract":"<p><p>The UNI-AJA project is a French epidemiological study analyzing cancer care pathways and outcomes in adolescents and young adults (AYAs, 15-29 years) from 2009 to 2022. Using data from 10 health institutions and national databases, it will examine treatment types, delays, second cancers, long-term effects, and causes of death. The study will employ deterministic linkage for comprehensive patient tracking. It will assess care evolution, the impact of AYA-specific structures, and treatment consequences. Findings will support improved cancer management and policy decisions in France. This project may lay the foundation for a national clinico-epidemiological database for AYAs with cancer.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Practices in the Use of Anti-Mullerian Hormone for Surveillance of Ovarian Function in Childhood Cancer Survivors: A Report from the Pediatric and Adolescent Committee of the Oncofertility Consortium.","authors":"Kari Bjornard, Allison Close, Julie Rios, Antoinette Anazodo, Jennifer Levine, Christine Yu, Leena Nahata, Lillian Meacham","doi":"10.1177/21565333251359617","DOIUrl":"https://doi.org/10.1177/21565333251359617","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Anti-Mullerian hormone (AMH) is a surrogate measure to assess ovarian reserve in childhood cancer survivors, but consensus is lacking on when to obtain and how to use AMH data. <b><i>Methods:</i></b> Pediatric and adolescent committee (PAC) members of the Oncofertility Consortium were invited by email to complete a survey regarding ovarian reserve surveillance and their use of AMH. Responses were collected through REDCap, and results were stratified by specialty: pediatric oncology and endocrinology (PED) or adult/pediatric gynecology and reproductive endocrinology (GYN). Descriptive statistics and Fisher's exact tests were used for analysis using SAS v9.4. <b><i>Results:</i></b> Surveys were completed by 48 of 123 eligible PAC members (28 PED, 19 GYN, response rate 39%). The majority (83.3%) reported using AMH as a measure of ovarian reserve, with the earliest timepoint to begin AMH surveillance to be 12-23 months from therapy completion (63%). While most respondents felt the benefits of testing outweighed the limitations (78.7%), commonly reported limitations included variability of results (60.4%) and lack of standardization in use of AMH (52.1%). Differences between PED and GYN respondents included how AMH was used among their clinical practice and the timing of laboratory evaluation. <b><i>Conclusions:</i></b> Most respondents indicated they used AMH; however, practices in its application varied depending on specialty backgrounds. Evidence-based clinical practice guidelines would improve the standardization of surveillance and counseling and prevent missed opportunities for fertility preservation in survivorship.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Community-Led Approach to Addressing Health Disparities among Adolescent and Young Adult Cancer Survivors.","authors":"Lauren V Ghazal, Alison Silberman, Ruzette Solis, Julye M Williams, Alexandra M Davis, Jacqueline E Shanley, Lauren Martino, Catherine Benedict, Bridgette Thom","doi":"10.1089/jayao.2025.0008","DOIUrl":"https://doi.org/10.1089/jayao.2025.0008","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Adolescent and young adult (AYA) cancer survivors (i.e., those diagnosed between the ages of 15 and 39 years) experience significant health and health care disparities. Formal evaluation of the role of community-based organizations in addressing these disparities is limited. Through a novel Health Equity Initiative, which included a series of community-driven conversations), Stupid Cancer, an AYA-focused cancer patient advocacy organization, sought to better understand the perceived impact of racism, homophobia, transphobia, and ableism on supportive cancer care among AYAs. <b><i>Methods:</i></b> This paper describes how Stupid Cancer developed and implemented its Health Equity Initiative programming (2021-2023) and presents findings from this program. Community-driven conversations comprised of several virtual focus groups, working groups, and town halls conducted via Zoom over the two years. We performed thematic analysis of transcripts from community-driven conversations. <b><i>Results:</i></b> Three themes were identified from community-driven conversations across initiative events 1) perception, 2) transition, and 3) representation. Based on these findings and further community discussions, four solutions were codeveloped with community members, which serve as proposed mechanisms for addressing identified health care inequities among AYA cancer survivors. <b><i>Conclusion:</i></b> Inclusivity and representation are vital components of AYA cancer care delivery. More research and quality improvement initiatives are needed to identify community-level interventions to mitigate health care disparities, ensuring all AYAs receive access to high-quality cancer care.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air Pollution and Cardiovascular Risks in Testicular Cancer Survivors: An Exploratory Case-Crossover Study.","authors":"Judy Y Ou, Joemy M Ramsay, Heydon K Kaddas, James A VanDerslice, Brock O'Neil, Sarah M García, Benjamin D Horne, Heidi Hanson, Anne C Kirchhoff","doi":"10.1089/jayao.2024.0144","DOIUrl":"10.1089/jayao.2024.0144","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> Testicular cancer survivors can experience cardiovascular and respiratory complications due to cancer treatment. We assessed associations between nitrogen dioxide (NO₂) and ozone (O₃) air pollution and health care encounters among survivors of adolescent and young adult (AYA) testicular cancer. <b><i>Methods:</i></b> A total of 385 AYA testicular cancer survivors, diagnosed 2000-2016, with cardiovascular and/or respiratory health care encounters (emergency department/urgent care [ED/UC], inpatient) were identified using a statewide Utah-based resource. Continuous and dichotomous (≥moderate air quality index) exposure measures were included for NO₂ and O₃ for the 1-4 days (lag days) before events. A case-crossover framework using conditional logistic regression with robust standard errors computed the association of lag days 0-3 with cardiovascular or respiratory encounters and stratified by encounter type (ED/UC, inpatient). Models that were significant in the full cohort were also stratified on demographic and treatment factors. All models were controlled for temperature and humidity. <b><i>Results:</i></b> Survivors contributed 257 cardiovascular and 685 respiratory encounters. NO₂ ≥moderate on lag day 1 was associated with increased odds of any cardiovascular encounter (odds ratio [OR] = 1.97, 95% confidence interval [CI] = 1.08-3.59) and inpatient cardiovascular encounters in the full cohort (OR = 2.48, 95% CI = 1.21-5.10), survivors treated with radical orchiectomy and chemotherapy (OR = 3.00, 95% CI = 1.29-7.00), and Hispanic survivors (OR = 4.32, 95% CI = 1.18-15.85). O₃ ≥moderate on lag day 4 was associated with respiratory ED/UC encounters (OR = 1.34, 95% CI = 1.00-1.79) and O₃ on lag day 4 was associated with any cardiovascular encounter (OR = 1.02/parts per billion [ppb], 95% CI = 1.00-1.03) and inpatient cardiovascular encounters (OR = 1.03/ppb, 95% CI + 1.00-1.05). <b><i>Conclusions:</i></b> NO₂ and O₃ are associated with risk for health care encounters among testicular cancer survivors and could increase health disparities in survivorship.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financial and Legal Burdens and Discrimination after Surviving a Childhood Cancer Diagnosis in Germany-Results from a Survey in the German Childhood Cancer Survivor Community.","authors":"Bjoern Hessing, Jette Luedersen, Lisa Scharping, Astrid Zehbe, Jennifer Gotta, Marie Alfes, Eva-Maria Wild","doi":"10.1089/jayao.2025.0026","DOIUrl":"https://doi.org/10.1089/jayao.2025.0026","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Since survival rates have improved over recent decades, there is an increasing number of childhood cancer survivors. Besides the late medical effects of the therapy, survivors experience financial and legal burdens and discrimination linked to their cancer history. The objective of this study was to examine the prevalence and types of discrimination faced by childhood cancer survivors in Germany. <b><i>Methods:</i></b> We conducted a survey in the German childhood cancer community assessing domains of discrimination. <b><i>Results:</i></b> Within 111 participants, recruited through social media campaigns and direct outreach to organizations in the field of pediatric oncology, 76.6% (<i>n</i> = 85) reported experiencing at least one form of discrimination. The most common areas of discrimination involved various types of insurance coverage (51.4%), employment (27.9%), and educational matters (16.2%). <b><i>Conclusion:</i></b> Our findings highlight the significant prevalence of lifelong financial and legal burdens and discrimination among childhood cancer survivors. It reveals the urgent need for education, awareness campaigns regarding cancer survival, and legal measures to end discrimination and to establish equal treatment in terms of social and financial issues. Our results contribute to the ongoing discussion surrounding the law named \"Right to be Forgotten\" and advocate an implementation in Germany.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and Enablers to Accessing a Young Adult Peer Support Group for Proton Beam Therapy Patients.","authors":"Karthica Santhagunanathan, Mark Ngo","doi":"10.1089/jayao.2025.0016","DOIUrl":"10.1089/jayao.2025.0016","url":null,"abstract":"<p><p>There is consensus among health care professionals that the needs of young adults (YAs) are poorly met. A service evaluation was performed, using semi-structured interviews to explore how YAs (<i>n</i> = 9) perceive peer support. Findings highlighted the importance of peer support in enhancing the patient experience by fostering meaningful connections and offering opportunities to serve as positive role models to others. Many YAs feel disconnected from their friends, making peer support a valuable source of normality. Participants expressed a preference for weekly 45-60-minute sessions and highlighted the importance of effective promotion and relevant discussion topics to encourage engagement.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}