Journal of adolescent and young adult oncology最新文献

{"title":"50-year Trends in Cancer Incidence and Mortality among Adolescents and Young Adults in British Columbia, Canada.","authors":"Jeenat Mehareen, Rachel MacKay Altman, Mary De Vera, Karen Goddard, Fuchsia Howard, X Joan Hu, Agnes S Lai, Andrea C Lo, Helen McTaggart-Cowan, Justin Oh, Muntasir Rahman, S Rod Rassekh, Caron Strahlendorf, Meera Rayar, Stuart Peacock","doi":"10.1177/21565333261470581","DOIUrl":"https://doi.org/10.1177/21565333261470581","url":null,"abstract":"<p><strong>Introduction: </strong>Adolescents and young adults (AYAs) with cancer constitute a distinct population with unique biological and survivorship challenges. Long-term, population-based analyses of incidence and mortality trends in AYAs remain limited.</p><p><strong>Methods: </strong>We conducted a retrospective, longitudinal population-based cohort study using data from the Childhood, Adolescent, and Young Adult Cancer Survivor program in British Columbia, Canada, from 1971 to 2020. We analyzed age-standardized incidence rates (ASIR) for the 16 cancer types with the highest incidence and age-standardized mortality rates (ASMR) for the 8 cancer types with the highest mortality, overall and by sex. Trends were evaluated using annual percentage change (APC) and average APC from joinpoint regression analyses.</p><p><strong>Results: </strong>The cohort included 43,588 patients with a first cancer diagnosis and 6825 deaths. From 1971 to 2020, cancer incidence rose overall (AAPC 0.1; 95% confidence interval [CI]: -1.0, 1.3), with a brief decline in the mid-1990s. Significant increases in ASIR were observed for thyroid (APC_1983-2020: 3.0, 95% CI: 2.4, 3.6) and gastrointestinal cancers (APC_1988-2020: 1.9, 95% CI: 1.3, 2.6). Female AYAs showed rising trends in Hodgkin and non-Hodgkin lymphoma, while testicular cancer incidence increased among males. Male AYAs had higher all-cause mortality (51.6%). Cancer mortality declined beginning in the early 1990s; however, gastrointestinal cancer mortality increased in males (APC_1990-2020: 1.7, 95% CI: 0.3, 3.1).</p><p><strong>Conclusions: </strong>Cancer incidence among AYAs has risen over five decades, particularly for thyroid and gastrointestinal cancers, with concerning increases in gastrointestinal cancer mortality among males. These findings emphasize the need for targeted prevention, screening, and intervention strategies.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261470581"},"PeriodicalIF":1.6,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AYA POWER: Feasibility and Early Outcomes of a Global Virtual AYA Oncology Education Curriculum.","authors":"Scott Moerdler, Kayla Fulginiti, Nicholas Giallourakis, Leslie Appiah, Sharon L Bober, Adam S DuVall, Karen E Effinger, David R Freyer, Allison Grimes, Brandon Hayes-Lattin, Jennifer W Mack, Varun Monga, John C Molina, Pinki K Prasad, John M Salsman, Michael E Roth","doi":"10.1177/21565333261470564","DOIUrl":"https://doi.org/10.1177/21565333261470564","url":null,"abstract":"<p><strong>Purpose: </strong>Adolescents and young adults (AYAs) with cancer face care disparities, compounded by a lack of formal AYA oncology education in pediatric and medical oncology fellowship programs. This critical workforce training gap hinders optimal AYA outcomes. We developed a virtual program, \"AYA POWER\" (Adolescent and Young Adult Program for Oncology Workforce Education and Resources), to provide high-yield education to improve care delivery and outcomes.</p><p><strong>Methods: </strong>AYA POWER is a virtual, longitudinal series addressing high-priority AYA topics. Content includes live lectures, on-demand recordings, and supplemental tools and materials. We evaluated the development, implementation, uptake, and impact via registration data, website analytics, and post-session feedback.</p><p><strong>Results: </strong>The curriculum launched in August 2023, attracting 1243 engagements with 653 live participants (395 unique attendees) and 590 on-demand views from 12 countries. Attendees represented diverse AYA stakeholders, including nurses, advanced practice providers, and oncologists. Feedback was overwhelmingly positive, emphasizing the content's relevance, practicality, and importance in addressing under-discussed topics.</p><p><strong>Conclusion: </strong>AYA POWER demonstrates the feasibility and early impact of a global, virtual, longitudinal AYA oncology curriculum. It successfully bridges a crucial educational void. Future integration into formal training and expanded outreach will enhance access to specialized AYA cancer care knowledge.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261470564"},"PeriodicalIF":1.6,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148446687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Affected Limb Pain and Associated Factors in Young Adult Survivors of Lower Limb Osteosarcoma in Japan.","authors":"Shoko Katsumoto, Motoko Okamitsu, Satoshi Yago, Shintaro Iwata, Keisuke Ae, Keiko Hayakawa, Tabu Gokita, Tsukasa Yonemoto","doi":"10.1177/21565333261464959","DOIUrl":"10.1177/21565333261464959","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to characterize affected-limb pain and its associated factors among adolescent and young adult (AYA) survivors of lower extremity osteosarcoma in Japan. We hypothesized that both physical and psychosocial factors would be associated with pain, with an interaction between pain intensity and pain interference.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among osteosarcoma survivors aged 18-39 years who had completed treatment at least 2 years earlier. Self-administered questionnaires assessed pain intensity and interference, physical function, fatigue, sleep disturbance, anxiety, depression, and perceived social support. Multiple regression analyses were performed to identify factors associated with pain outcomes. Semistructured interviews were also conducted to provide supplementary insights into pain characteristics and contextualize the quantitative findings.</p><p><strong>Results: </strong>Among 64 participants, 65.6% reported pain or pain interference during the preceding 7 days. Pain intensity was significantly associated with poorer physical function, older age at diagnosis, and lower perceived social support, whereas pain interference was primarily associated with greater fatigue severity. Pain intensity and pain interference were strongly correlated. Qualitative analysis identified four pain characteristics prosthesis-related pain, phantom limb pain, secondary pain, and weather-related pain. Interviews further illustrated how physical limitations, fatigue, and social support shaped pain experiences.</p><p><strong>Conclusion: </strong>Pain among long-term osteosarcoma survivors is influenced by multiple biopsychosocial factors. Although average pain severity was relatively mild, substantial interindividual variability was observed. Comprehensive survivorship care should address physical function, fatigue management, and social support to optimize long-term pain management and self-care among AYA osteosarcoma survivors.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261464959"},"PeriodicalIF":1.6,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148404735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective SAJAC Study of Rehabilitation for Adolescents and Young Adults with Cancer in a Comprehensive Cancer Center.","authors":"Emmanuelle Bompas, Audrey Blanc Lapierre, Josselin Sebille, Sophie Allain, Marie Quereau, Solene Wallez, Nelly Soulard, Dominique Berton, Ludovic Doucet, Hélène Senellart, Jean-Sébastien Frenel, Mélanie Doré, Frédéric Rolland, Mario Campone, Sandrine Hiret, Emmanuelle Bourbouloux, Pierre Kubicek, Baptiste Sauterey, Céline Thomas, Marianne Bourdon","doi":"10.1177/21565333261464958","DOIUrl":"https://doi.org/10.1177/21565333261464958","url":null,"abstract":"<p><strong>Background: </strong>Youth patient organizations have taken action to address the specific needs of adolescents and young adults (AYAs), and the third National Cancer Control Plan has made this a requirement. This study presents the center's rehabilitation program.</p><p><strong>Patients and methods: </strong>Following initial treatment, patients aged 18-25 were seen annually for 5 years by a multidisciplinary team. Quality of life using the World health organization quality of life (WHOQOL)-BREF and anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) were assessed. The sexologist developed his own scale. The Patients' Global Impression of Change scale (P-GIC) was used to evaluate patients' feedback about the program.</p><p><strong>Results: </strong>Forty-five patients were included. The main reason for being unable to work effectively was cancer and/or its treatment for 20 patients out of 23 in activity (87%). Ten patients (22.2%) reported financial difficulties, and 14 patients (31.1%) received support from a social worker. Regarding sexological accompaniment, only 17 patients could be evaluated; most of these patients (<i>N</i> = 11, 65%) required a sexologist appointment more than a year after the end of their treatment. Regarding psychological support, 44 patients completed the WHOQOL-BREF questionnaire. No particular trend was observed over time. A total of 45 patients completed the HADS. Symptoms of depression may decrease over time, from the end of the treatment to up to 5 years later, whereas anxiety symptoms may not. Of the 48 responses received for the P-GIC satisfaction survey, 43 (89%) indicated satisfaction.</p><p><strong>Conclusion: </strong>The AYA team conducts systematic needs assessment and works to address these needs.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261464958"},"PeriodicalIF":1.6,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics, Psychosocial Concerns, and Supportive Care Needs in Young Adults with Colorectal Cancer.","authors":"Hayato Yamaguchi, Masakatsu Fukuzawa, Takashi Kawai, Midori Muzumachi, Tomohiro Ida, Fumito Yamanishi, Tadashi Ichimiya, Daiki Nemoto, Takahiro Muramatsu, Yasuyuki Kagawa, Kumiko Uchida, Akira Madarame, Takashi Morise, Yoshiya Yamauchi, Shin Kono, Sakiko Naito, Takao Itoi","doi":"10.1177/21565333261464965","DOIUrl":"10.1177/21565333261464965","url":null,"abstract":"<p><strong>Introduction: </strong>The incidence of colorectal cancer (CRC) in adolescents and young adults is increasing, and affected individuals often face diagnostic delays, psychological distress, fertility-related concerns, and limited access to social support. Few studies have evaluated these multidimensional factors. This study aimed to clarify the clinical characteristics, psychosocial burden, fertility-related issues, and support needs of young adults with CRC.</p><p><strong>Patients and methods: </strong>Patients aged 15-39 years diagnosed with CRC between 2012 and 2025 were evaluated. Clinical characteristics, psychological distress, fertility-related concerns, and utilization of social support resources were assessed using medical records, nursing documentation, multidisciplinary reports, and institutional assessment tools. Documented psychological and fertility concerns were categorized, and survival outcomes were estimated using the Kaplan-Meier method.</p><p><strong>Results: </strong>Symptom-driven diagnosis occurred in 59.2% overall and was significantly more common in patients in their 20 seconds (91.7% vs 52.5%, <i>p</i> = 0.011). Screening-based detection was lower in the 20 seconds (16.7%) than in the 30 seconds (49.2%, <i>p</i> = 0.039). Advanced disease (Stage II-IV) accounted for 56.3% of cases and was associated with poorer survival (<i>p</i> = 0.013). Psychological distress was documented in 77.5% of patients. Fertility-related anxiety occurred in 22.5% and was more frequent in women (35.5% vs 12.5%, <i>p</i> = 0.022). Fertility preservation was performed in 9.9%. Social worker involvement was noted in 66.2%, while use of public support systems remained low.</p><p><strong>Conclusion: </strong>Young adults with CRC face delayed diagnosis, substantial psychological distress, sex-specific fertility concerns, and limited engagement with public support programs. Improved symptom recognition, routine distress screening, gender-inclusive fertility counseling, and strengthened multidisciplinary support are needed for this population.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261464965"},"PeriodicalIF":1.6,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Online Information for Young Adult Cancer Symptoms: A Content Analysis of Top Google-Ranked Webpages.","authors":"Natasha C Allard, Heather Orom","doi":"10.1177/21565333261464961","DOIUrl":"10.1177/21565333261464961","url":null,"abstract":"<p><strong>Background: </strong>Among young adults (20-39), cancer is the fifth leading cause of death. Delayed diagnoses in this population are frequent, contributing to reduced survival and higher morbidity. Delays may be driven by individuals attributing symptoms as nonserious and failing to seek timely medical care. Google search is commonly used for health information seeking, but we do not know the current online symptom content quality that young adults may encounter.</p><p><strong>Purpose: </strong>We aimed to answer 1. What is the content quality of top-ranked webpages for common young adult cancer symptom searches? 2. Does quality differ by website type (e.g., academic/health care vs. for profit)?</p><p><strong>Methods: </strong>Using 18 young adult cancer symptoms as input into the SEMRush Keyword Magic Tool, we generated a list of the most common keyword searches and the top-ranked webpages (i.e., first three pages listed in Google output). We evaluated 162 pages on 9 quality metrics, including the JAMA benchmark criteria.</p><p><strong>Results: </strong>Two-thirds of pages (66.7%, <i>n</i> = 108) were written at less than a 9th-grade reading level, and three-quarters (72.8%, <i>n</i> = 118) provided actionable content about when to seek medical care for symptoms. However, only 13.6% (<i>n</i> = 22) of pages included content framed for young adults. On average, pages met about half (2.33) of four JAMA criteria (authorship, disclosures, currency/up-to-date, and references).</p><p><strong>Conclusion: </strong>Academic/health and government organizations should devote resources to improving information about young adult cancer symptoms on their webpages and optimize these pages to appear higher in search result rankings.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261464961"},"PeriodicalIF":1.6,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurofilament Light Chain: A Potential Biomarker for Chemotherapy-Induced Peripheral Neuropathy in Adolescent Young Adults.","authors":"Jennifer A Belsky, Allie Carter, Michael E Roth, Audrey Leisinger, Jeffery Dage, Etan Orgel, AnnaLynn M Williams, Bryan P Schneider, Ellen M Smith","doi":"10.1177/21565333261464963","DOIUrl":"https://doi.org/10.1177/21565333261464963","url":null,"abstract":"<p><p><i>Background:</i> Neurofilament light chain (NfL)is a promising biomarker of axonal injury and may facilitate earlier detection of chemotherapy-induced peripheral neuropathy (CIPN). This study evaluated longitudinal changes in NfL and its association with patient-reported CIPN symptoms in adolescents and young adults receiving neurotoxic chemotherapy. <i>Methods:</i> In this prospective, single-center study, patients >10 years of age with cancer receiving atubulin toxin were enrolled. Serum NfL and the Functional Assessment of Cancer Therapy-Gynecologic Oncology Group-Neurotoxicity (FACT-GOG-NTx) questionnaire were collected at baseline, midchemotherapy, and at the follow-up visit closest to 90 days after therapy initiation.<i>Results:</i> Eleven participants (median age 17 years [range, 12-24]; 63.6% male) were included. NfL levels increased longitudinally in all participants, with a median maximum increase from baseline of 112.5% (range, -32.0% to 4896.2%). Mean NfL levels increased from 2.32 at baseline (median 2.16) to 3.28 at mid-chemotherapy (median 3.47) and remained elevated at the follow-up visit (mean 3.85; median 4.38). Higher NfL levels were associated with worse FACT-GOG-NTx scores during chemotherapy (<i>r</i> = -0.32, <i>p</i> ≤ 0.01) and after chemotherapy (<i>r</i> = -0.31, <i>p</i> < 0.01).<i>Conclusions:</i> NfL increased throughout treatment and was associated with patient reported CIPN symptoms, supporting its potential as an objective biomarker for early detection and monitoring of chemotherapy-induced peripheral neuropathy in adolescents and young adults receiving neurotoxic chemotherapy.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261464963"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical Consultation Utilization Patterns in Adolescent and Young Adult Oncology: A 10-Year Single-Center Study and Contemporary Ethics Framework.","authors":"Rachel N Zeno, Miza Salim Hammoud, Kate Eshleman, Arjan Kalra, Kara Bendle, Joshua S Crites, Stefanie M Thomas","doi":"10.1177/21565333261464967","DOIUrl":"https://doi.org/10.1177/21565333261464967","url":null,"abstract":"<p><strong>Background: </strong>Adolescents and young adults (AYAs; 15-39 years) with cancer face unique ethical challenges. Variations in ethics consultations (ECs) among different AYA age groups remain understudied, despite evolving developmental and psychosocial milestones.</p><p><strong>Methods: </strong>A 10-year retrospective review at an academic medical center examined EC cases in AYA oncology patients. Ethicists categorized ethical issues using an institutional 5 domains, 23-category classification schema Decisional Processes, Medical/Surgical Treatments, Patient/Family Behavior, Professional Issues, and Information/Communication. Categories included surrogate decision-making, informed consent, pain management, and resuscitation status/do-not-resuscitate (DNR) order. Multiple categories could be documented per EC. Primary outcomes were (1) the distribution of categories across domains and (2) the prevalence of specific categories among patients, compared across age groups (15-21, 22-29, and 30-39 years) using χ² or Fisher's exact tests (α = 0.05).</p><p><strong>Results: </strong>Among 59 ECs (mean patient age 26.4 ± 7.1 years; 52.5% female), Decisional Processes accounted for 41% of category applications, followed by Medical/Surgical Treatments (25%), Patient/Family Behavior (12%), Professional Issues (12%), and Information/Communication (9%). A total of 153 categories were recorded. The most common were surrogate decision-making (45%), quality-of-life (QoL) considerations (37%, including QoL deliberations [20%] and treatment-related QoL concerns [17%]), informed consent (20%), and DNR (18%). The distribution was consistent across age groups, except for pain control, observed only in 22-29-year-olds (3/16; <i>p</i> = 0.014).</p><p><strong>Conclusion: </strong>Decision-making primarily drove EC with consistent patterns across the AYA spectrum, except for pain control in 22-29-year-olds. Findings emphasize the need for structured decision-making approaches and age-specific pain management in AYA oncology.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261464967"},"PeriodicalIF":1.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Advanced Triple Positive Breast Cancer Developed Endometrial Metastasis After Anti-HER2-Based Therapy Failed: A Case Report and Review.","authors":"Shanshan Deng, Junzhu Xu, Dingning Deng, Xin Li, Cai Ying, Hu Ma, Jian-Guo Zhou","doi":"10.1177/21565333261464973","DOIUrl":"10.1177/21565333261464973","url":null,"abstract":"<p><p>Early endometrial metastasis from triple-positive breast cancer is a rare phenomenon in young patients, especially when anti-human epidermal growth factor receptor 2 (HER2) target therapy is used as the primary treatment. We present a case of a 24-year-old patient with advanced triple positive breast cancer. The patient developed abnormal uterine bleeding during chemotherapy combined with anti-HER2 therapy (trastuzumab plus pyrotinib). Due to the transvaginal sonography are not characteristic and the low incidence rate of endometrial metastasis from breast cancer, this potential diagnosis was overlooked. The disease progressed rapidly thereafter, and the overall survival was only 13 months. The swift and devastating progression highlight the immense challenges in managing such complex cases. It remains a current challenge to identify such cases at an early stage and explore more effective therapeutic regimens. Based on this case review and previous studies, we speculate that disease progression might be attributed to the absence of endocrine therapy, chemotherapy resistance, or insufficient anti-HER2 therapeutic intensity. This case provides new insights into the metastatic pattern of HER2-positive breast cancer under targeted drug resistance. Clinicians should be alert to the possibility of reproductive system metastasis during anti-tumor treatment. Timely diagnosis and appropriate treatment are expected to improve patient prognosis.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261464973"},"PeriodicalIF":1.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbrella Review of Psychosocial, Physical, and Combined Interventions for Adolescents and Young Adults with Cancer: Impacts on Quality of Life and Health-Related Outcomes.","authors":"Perizat Aitmaganbet, Lunara Ishimova, Anar Tulyayeva, Maya Alibekova, Guldana Eskabylova","doi":"10.1177/21565333261464971","DOIUrl":"https://doi.org/10.1177/21565333261464971","url":null,"abstract":"<p><strong>Relevance: </strong>Adolescents and young adults (AYAs) diagnosed with cancer represent a particularly vulnerable group with unique developmental, psychosocial, and functional challenges. Beyond survival, improving health-related quality of life (HRQoL) has become a major priority in cancer survivorship and public health.</p><p><strong>Purpose: </strong>This umbrella review aimed to critically synthesize evidence from existing systematic reviews and meta-analyses evaluating the effectiveness of physical, psychosocial, and mixed interventions for improving HRQoL and related health outcomes in AYA (e.g., cancer-related fatigue, anxiety, and physical functioning) cancer patients and survivors.</p><p><strong>Methods: </strong>A comprehensive search of PubMed/MEDLINE, Web of Science, Cochrane Database of Systematic Reviews, and ScienceDirect identified eligible systematic reviews and meta-analyses published between 2015 and 2025.</p><p><strong>Results: </strong>Fifteen reviews were included. Physical activity interventions showed the most consistent moderate benefits, particularly in reducing fatigue and improving physical functioning and domain-specific HRQoL. Psychosocial interventions demonstrated small-to-moderate improvements in anxiety, depression, and emotional well-being. Mixed interventions showed promising but less robust evidence, particularly due to limited long-term follow-up. Overall evidence certainty ranged from low to moderate. Primary study redundancy was minimal (the corrected covered area = 1.7%).</p><p><strong>Conclusions: </strong>Psychosocial interventions, especially exercise-based and psychosocial programs, can improve key HRQoL domains in AYAs with cancer. However, more rigorous long-term studies are required, particularly for combined and digital approaches.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261464971"},"PeriodicalIF":1.6,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}