Journal of adolescent and young adult oncology最新文献_第10页

Effect of Acupuncture and Massage on Pain in Adolescent and Young Adult Patients with Advanced Cancer: Subgroup Analysis of a Randomized Clinical Trial. 针刺和按摩对青少年晚期癌症患者疼痛的影响：一项随机临床试验的亚组分析。

IF 1.6 4区医学

Journal of adolescent and young adult oncology Pub Date : 2026-04-01 Epub Date: 2026-02-19 DOI: 10.1177/21565333251368891

Han-Wei V Wu, Xiaotong Li, Qing S Li, Raymond E Baser, Katherine S Panageas, Susan Chimonas, William D Tap, Julia Glade Bender, Chaya S Moskowitz, Jun J Mao

{"title":"Effect of Acupuncture and Massage on Pain in Adolescent and Young Adult Patients with Advanced Cancer: Subgroup Analysis of a Randomized Clinical Trial.","authors":"Han-Wei V Wu, Xiaotong Li, Qing S Li, Raymond E Baser, Katherine S Panageas, Susan Chimonas, William D Tap, Julia Glade Bender, Chaya S Moskowitz, Jun J Mao","doi":"10.1177/21565333251368891","DOIUrl":"10.1177/21565333251368891","url":null,"abstract":"Purpose: Pain management remains challenging for adolescent and young adult (AYA) cancer patients. Acupuncture and massage have been recommended for cancer-related pain management, but no prospective trials have been conducted in AYA patients. We explored the effects of acupuncture and massage on pain in AYAs.Methods: This subgroup analysis focused on AYA patients (aged 18-39 years) enrolled in a randomized controlled trial comparing acupuncture and massage for pain management in advanced cancer. Interventions were delivered weekly for 10 weeks, followed by monthly booster treatments through week 26. The primary outcome was the worst pain score from the Brief Pain Inventory, analyzed using a linear mixed-effects model.Results: Thirty participants met eligibility criteria (13 acupuncture; 17 massage), with a mean age of 31.1 years (standard deviation, 5.8); 57% were female; 67% were White; and 53% had solid tumors. Both groups experienced reduced pain over time. Relative to baseline, patients receiving acupuncture had a mean change of -1.26 points (95% confidence interval [CI], -2.54 to 0.01) at 10 weeks and a mean change of -1.46 points (95% CI, -2.78 to -0.14) at 26 weeks. Patients receiving massage experienced a mean change of -2.81 points (95% CI, -3.92 to -1.70) at week 10 and a mean change of -3.79 points (95% CI, -4.85 to -2.73) at week 26.Conclusion: AYA patients with advanced cancer who received either acupuncture or massage experienced clinically meaningful and sustained reductions in pain. These findings provide a promising foundation for future trials aimed at evaluating integrative pain management strategies in AYAs.","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"85-93"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144846542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feedback on Adapting Interventions for AYA Cancer Survivors' and Caregivers' Psychological Distress, Symptom Management, and Health Care Use. 对AYA癌症幸存者和照顾者心理困扰、症状管理和卫生保健使用的适应性干预的反馈。

IF 1.6 4区医学

Journal of adolescent and young adult oncology Pub Date : 2026-04-01 Epub Date: 2025-12-11 DOI: 10.1177/21565333251369687

Echo L Warner, Jennifer Traslavina Jimenez, Alla Sikorskii, Chris Segrin, Tracy Crane, Terry A Badger

{"title":"Feedback on Adapting Interventions for AYA Cancer Survivors' and Caregivers' Psychological Distress, Symptom Management, and Health Care Use.","authors":"Echo L Warner, Jennifer Traslavina Jimenez, Alla Sikorskii, Chris Segrin, Tracy Crane, Terry A Badger","doi":"10.1177/21565333251369687","DOIUrl":"10.1177/21565333251369687","url":null,"abstract":"Purpose: Adolescents and young adults (AYAs) experience higher burdens of negative psychological outcomes (e.g., depression, anxiety, and stress) of cancer compared to older survivors and caregivers. We elicited feedback about the adaptation of two randomized controlled trials (RCTs), one using a symptom management and survivorship handbook (SMSH) and another using telephone-based interpersonal counseling, for AYA cancer survivors and caregivers of AYAs.Methods: Following the parent RCT, we conducted a follow-up study using semi-structured telephone interviews to elicit feedback from AYAs (ages 18-39 years at diagnosis) and adult caregivers of AYAs (aged 18+). Participants were asked to share satisfaction with the (1) content, (2) delivery, and (3) general experiences in the study. Interviews were recorded, transcribed, and quality checked. We categorized qualitative feedback through interpretive description.Results: There were N = 18 participants 10 women and 8 men; 8 cancer survivors and 10 caregivers. The interviews were 5-20 minutes (average = 10.5 minutes). Participants enjoyed the content and found the information helpful. Participants preferred digital materials for accessing information about cancer symptom management and treatment. Some participants continue to use the information from the SMSH after their participation.Conclusions: AYA cancer survivors and caregivers of AYAs were largely satisfied with the content of the intervention materials. Minor suggestions arose to modify the intervention materials to be more suitable through including digital materials and social connections.","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"134-142"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The UNI-AJA Project: A Feasibility Study Based on Real-World Data in French Adolescents and Young Adults with Cancer. UNI-AJA项目：基于法国青少年和青年癌症患者真实世界数据的可行性研究。

IF 1.2 4区医学

Journal of adolescent and young adult oncology Pub Date : 2026-04-01 Epub Date: 2026-02-19 DOI: 10.1177/21565333251359614

Emmanuel Desandes, Alizée Diatchenko, Hugo Crochet, Nicolas André, Jean-Yves Blay, Nathalie Gaspar, Lionnel Geoffrois, Sabine Heinrich, Pierre Kubicek, Valérie Laurence, Pierre Leblond, Cyril Lervat, Lise Molimard, Marilyne Poirée, Marion Salomon, Jill Serre, Maud Toulmonde, Pascale Varlet, Thierry Durand, Françoise Ducimetière, Perrine Marec-Berard

引用次数: 0

Perspectives on Care Plans for Adolescent and Young Adult Survivors of Childhood Cancer: A Qualitative Evaluation of Survivors, Caregivers, and Oncology and Primary Care Practitioners. 儿童癌症的青少年和青年幸存者护理计划的观点：幸存者、护理者、肿瘤和初级保健从业人员的定性评估。

IF 1.6 4区医学

Journal of adolescent and young adult oncology Pub Date : 2026-04-01 Epub Date: 2026-03-10 DOI: 10.1177/21565333251362113

Katie Darabos, Janet A Deatrick, Courtney Benjamin Wolk, Bridget O'Hagan, Sara King-Dowling, Dava Szalda, Wendy Hobbie, Lamia P Barakat, Christine Hill-Kayser, Lisa A Schwartz

{"title":"Perspectives on Care Plans for Adolescent and Young Adult Survivors of Childhood Cancer: A Qualitative Evaluation of Survivors, Caregivers, and Oncology and Primary Care Practitioners.","authors":"Katie Darabos, Janet A Deatrick, Courtney Benjamin Wolk, Bridget O'Hagan, Sara King-Dowling, Dava Szalda, Wendy Hobbie, Lamia P Barakat, Christine Hill-Kayser, Lisa A Schwartz","doi":"10.1177/21565333251362113","DOIUrl":"10.1177/21565333251362113","url":null,"abstract":"Purpose: Treatment advances have led to a rapidly growing population of adolescent and young adult (AYA, ages 15-29) survivors of childhood cancer. Despite cure, AYA are physically and psychologically vulnerable due to treatment toxicity, leading 70% to develop second cancers or chronic, often life-threatening, late effects. Self-management is critical for survivorship and includes lifelong follow-up care, health promotion, disease surveillance, and management of late effects. Survivorship care plans (SCPs) are documents to inform survivors and providers of recommendations for management of survivor health and to improve communication among providers. With limited SCP research to date, there are calls for rigorous research to understand SCP implementation.Methods: Qualitative semistructured interviews were conducted to assess perceptions about SCPs, including barriers and facilitators of SCP implementation among 12 purposefully sampled AYAs who received an SCP in the extant trial, 8 caregivers of AYA, 10 oncology providers, and 8 pediatric primary care providers.Results: Overall, SCPs were viewed as generally positive by AYA and caregivers, with caveats about ways to improve them or use them. Oncology providers also generally had a positive view of the SCP, but primary care practitioners found them to be less targeted to their specific needs.Conclusion: Our results helped to clarify critical aspects of implementation that need to be addressed if SCPs are to be successfully implemented into survivorship care for AYA, especially as they transition to adult-oriented health care.","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"115-123"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Practices in the Use of Anti-Mullerian Hormone for Surveillance of Ovarian Function in Childhood Cancer Survivors: A Report from the Pediatric and Adolescent Committee of the Oncofertility Consortium. 目前使用抗苗勒管激素监测儿童癌症幸存者卵巢功能的实践：一份来自肿瘤生育联合会儿科和青少年委员会的报告。

IF 1.2 4区医学

Journal of adolescent and young adult oncology Pub Date : 2026-04-01 Epub Date: 2026-03-10 DOI: 10.1177/21565333251359617

Kari Bjornard, Allison Close, Julie Rios, Antoinette Anazodo, Jennifer Levine, Christine Yu, Leena Nahata, Lillian Meacham

{"title":"Current Practices in the Use of Anti-Mullerian Hormone for Surveillance of Ovarian Function in Childhood Cancer Survivors: A Report from the Pediatric and Adolescent Committee of the Oncofertility Consortium.","authors":"Kari Bjornard, Allison Close, Julie Rios, Antoinette Anazodo, Jennifer Levine, Christine Yu, Leena Nahata, Lillian Meacham","doi":"10.1177/21565333251359617","DOIUrl":"10.1177/21565333251359617","url":null,"abstract":"Purpose: Anti-Mullerian hormone (AMH) is a surrogate measure to assess ovarian reserve in childhood cancer survivors, but consensus is lacking on when to obtain and how to use AMH data.Methods: Pediatric and adolescent committee (PAC) members of the Oncofertility Consortium were invited by email to complete a survey regarding ovarian reserve surveillance and their use of AMH. Responses were collected through REDCap, and results were stratified by specialty: pediatric oncology and endocrinology (PED) or adult/pediatric gynecology and reproductive endocrinology (GYN). Descriptive statistics and Fisher's exact tests were used for analysis using SAS v9.4.Results: Surveys were completed by 48 of 123 eligible PAC members (28 PED, 19 GYN, response rate 39%). The majority (83.3%) reported using AMH as a measure of ovarian reserve, with the earliest timepoint to begin AMH surveillance to be 12-23 months from therapy completion (63%). While most respondents felt the benefits of testing outweighed the limitations (78.7%), commonly reported limitations included variability of results (60.4%) and lack of standardization in use of AMH (52.1%). Differences between PED and GYN respondents included how AMH was used among their clinical practice and the timing of laboratory evaluation.Conclusions: Most respondents indicated they used AMH; however, practices in its application varied depending on specialty backgrounds. Evidence-based clinical practice guidelines would improve the standardization of surveillance and counseling and prevent missed opportunities for fertility preservation in survivorship.","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"94-101"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Children's Oncology Group Survey Exploring Practices and Barriers to Sperm Banking for Post-Pubertal Males with Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia. 一项儿童肿瘤小组调查探讨了青春期后男性新诊断的高风险急性淋巴细胞白血病的做法和精子银行的障碍。

IF 1.2 4区医学

Journal of adolescent and young adult oncology Pub Date : 2026-04-01 Epub Date: 2026-03-10 DOI: 10.1177/21565333251364084

Jessica L Feuerstein, Burton Appel

引用次数: 0

Adaptive Psychosocial Outcomes in Cancer Predisposition Syndromes: A Scoping Review. 癌症易感性综合征的适应性社会心理结局：范围综述。

IF 1.2 4区医学

Journal of adolescent and young adult oncology Pub Date : 2026-04-01 Epub Date: 2026-02-19 DOI: 10.1177/21565333251366387

Joan W Hanania, Kevin K Tsang, Chloe Rotman

{"title":"Adaptive Psychosocial Outcomes in Cancer Predisposition Syndromes: A Scoping Review.","authors":"Joan W Hanania, Kevin K Tsang, Chloe Rotman","doi":"10.1177/21565333251366387","DOIUrl":"10.1177/21565333251366387","url":null,"abstract":"An increasing number of cancer predisposition syndromes (CPSs) have been associated with childhood cancer in light of advent advances in genomic medicine. While children and adolescents with CPSs present with compounded medical and psychosocial sequalae across the developmental trajectory, little is known about how adaptive psychosocial outcomes are conceptualized and promoted. Exploring adaptive and modifiable targets in psychological care may potentially promote coping among patients with CPSs and their families. The study undertakes a scoping review to describe, synthesize, characterize, and identify gaps in the literature on adaptive psychosocial outcomes among young people with CPSs and their caregivers. Adhering to PRISMA Extension guidelines and checklist, a systematic search in four databases was most recently conducted in February 2024: (PubMed, EMBASE, CINAHL, and PsycINFO). A total of 642 titles were screened and 36 articles were reviewed at the full-text level. Of those, five met the study inclusion criteria. The majority of articles were descriptive and centered around caregivers of at-risk patients with CPSs. The scoping review describes what is known about adaptive psychosocial outcomes associated with pediatric CPS and underscores the substantial gap in existing literature. Several important findings were identified across studies: significance of undergoing genetic testing, perceived surveillance benefits, positive psychological outcomes, intra-family communication, young people and caregiver psychosocial support. Future research is needed to investigate adaptive psychosocial outcomes associated with CPSs and delineate potential coping mechanisms. Findings may inform the development and dissemination of evidence-based psychological approaches designed to promote coping with pediatric CPSs.","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"153-159"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Program Delivery and Change in Patient-Reported Outcomes of an Age-Specific Rehabilitation Program for Young Adult Cancer Survivors: A Feasibility Study. 一项针对年轻成年癌症幸存者的年龄特异性康复计划的实施和患者报告结果的变化：可行性研究。

IF 1.2 4区医学

Journal of adolescent and young adult oncology Pub Date : 2026-04-01 Epub Date: 2025-12-11 DOI: 10.1177/21565333251372461

Maria Aagesen, Marc Sampedro Pilegaard, Kirsten Holstein Ipsen, Dorthe Søsted Jørgesen, May Aasebø Hauken, Karen la Cour

{"title":"Program Delivery and Change in Patient-Reported Outcomes of an Age-Specific Rehabilitation Program for Young Adult Cancer Survivors: A Feasibility Study.","authors":"Maria Aagesen, Marc Sampedro Pilegaard, Kirsten Holstein Ipsen, Dorthe Søsted Jørgesen, May Aasebø Hauken, Karen la Cour","doi":"10.1177/21565333251372461","DOIUrl":"10.1177/21565333251372461","url":null,"abstract":"Purpose: This study evaluated the program delivery of a part of the age-specific intervention Young Adult Taking Action (YATAC), a rehabilitation program for young adult cancer survivors, focusing on dose, adherence, fidelity and adaptation. It also explored changes in health-related quality of life, fatigue, depression, anxiety, and loneliness.Methods: A one-armed feasibility study with 19 young adult cancer survivors (aged 18-39) involved in a multicomponent rehabilitation program a 5-day residential stay, a 10-week home-based period, and a 2-day follow-up. Program delivery data were collected during the stays, and patient-reported outcomes were assessed at baseline and 10 weeks. Changes were analyzed using the Wilcoxon signed-rank test, and responder analysis assessed minimal clinically relevant changes.Results: All sessions were delivered, with 100% of participants completing the five-day and a two-day stay. Adherence and fidelity were both 83%, though 30% of sessions reported time constraints. Significant improvements were observed in cognitive functioning (p = 0.0046), fatigue (p = 0.0066), and anxiety (p = 0.0146). More participants showed minimal clinically relevant improvements in cognitive functioning (63%) than deteriorations. Fatigue was the only outcome with no reported clinically relevant deterioration.Conclusion: The tested part of the YATAC program demonstrated feasibility with high adherence and fidelity. Some adjustments to session duration and structure are needed. The program showed potential to improve cognitive function, fatigue, and anxiety, though findings should be interpreted cautiously due to the small sample size and one-armed design.","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"124-133"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Palliative Care Needs Among Adolescent and Young Adult Patients with Cancer and Their Caregivers in South Korea. 评估韩国青少年和青年癌症患者及其护理人员的姑息治疗需求。

IF 1.6 4区医学

Journal of adolescent and young adult oncology Pub Date : 2026-03-30 DOI: 10.1177/21565333261438421

Suheon Oh, Seung Yeon Kwon, Mikyung Park, Hyeon-Jin Kim, Hye Joung Cho, Hyun Ji Hong, Sowon Kim, Hyeon Jin Park, Meerim Park, Hee Jo Baek, Jun Ah Lee

{"title":"Assessing Palliative Care Needs Among Adolescent and Young Adult Patients with Cancer and Their Caregivers in South Korea.","authors":"Suheon Oh, Seung Yeon Kwon, Mikyung Park, Hyeon-Jin Kim, Hye Joung Cho, Hyun Ji Hong, Sowon Kim, Hyeon Jin Park, Meerim Park, Hee Jo Baek, Jun Ah Lee","doi":"10.1177/21565333261438421","DOIUrl":"10.1177/21565333261438421","url":null,"abstract":"Purpose: Adolescents and young adults (AYAs) with cancer experience unique physical, psychosocial, and developmental challenges that differ from those of children and older patients. While palliative care can address these challenges, the care needs of AYAs with cancer and their families are underrecognized and inadequately supported globally and in South Korea. This study aimed to assess the unmet palliative care needs of AYAs with cancer and their caregivers in South Korea.Methods: A cross-sectional survey design was conducted using two validated instruments developed for AYA patients (15-39 years) and their caregivers. Between August 2023 and November 2024, participants were recruited from three major hospitals in South Korea. Descriptive and inferential statistics were used to determine domain-specific needs and group-level differences.Results: Communication and information needs were most frequently unmet across all groups, whereas physical needs were often rated as \"already provided.\" Caregivers-especially of adolescent patients-reported greater unmet needs than patients. Conversely, young adult patients reported the lowest need across all domains. In the caregiver-centered survey, financial and bereavement support were top priorities.Conclusion: This study identified unmet palliative care needs, especially nonphysical ones, among AYA patients and their caregivers. The findings underscore the need for age-appropriate, culturally sensitive services, with a greater focus on communication/information and psychosocial care, and the importance of including caregivers' perspectives in building comprehensive palliative care models. Future studies should explore contextual factors that shape care perceptions and develop standardized screening tools to identify AYAs' specific needs.","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261438421"},"PeriodicalIF":1.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gonadal Dysfunction in Male Childhood Cancer Survivors: A Report from the St. Luke's Childhood Cancer Survivors Cohort Study (LUKE Cohort Study). 男性儿童癌症幸存者的性腺功能障碍：来自St. Luke儿童癌症幸存者队列研究（Luke队列研究）的报告。

IF 1.2 4区医学

Journal of adolescent and young adult oncology Pub Date : 2026-03-30 DOI: 10.1177/21565333261438096

Hiroki Yoshihara, Saori Aiga, Megumi Hatano, Kyoko Nagase, Michiyo Gunji, Yuri Yoshimoto Suzuki, Yosuke Hosoya, Yasushi Ishida, Kyoko Kobayashi, Atsushi Manabe, Daisuke Hasegawa, Miwa Ozawa

{"title":"Gonadal Dysfunction in Male Childhood Cancer Survivors: A Report from the St. Luke's Childhood Cancer Survivors Cohort Study (LUKE Cohort Study).","authors":"Hiroki Yoshihara, Saori Aiga, Megumi Hatano, Kyoko Nagase, Michiyo Gunji, Yuri Yoshimoto Suzuki, Yosuke Hosoya, Yasushi Ishida, Kyoko Kobayashi, Atsushi Manabe, Daisuke Hasegawa, Miwa Ozawa","doi":"10.1177/21565333261438096","DOIUrl":"https://doi.org/10.1177/21565333261438096","url":null,"abstract":"Purpose: Male childhood cancer survivors (CCS) are at increased risk of hypogonadism, which may be overlooked due to subtle symptoms. Early detection of male hypogonadism remains challenging. In Japan, lacking a nationwide surveillance system for gonadal dysfunction in CCS, few studies focus on male CCS. This study aimed to prospectively identify compensated primary hypogonadism (cPH) among male CCS using a comprehensive medical checkup system.Methods: We prospectively recruited CCS aged 18 and older who had been diagnosed with pediatric cancer over 10 years ago and untreated for more than 5 years. Physical checkup and mental health examination were conducted for both CCS and healthy CCS siblings, and analyzed data from male participants. We defined cPH if their testicular volume was 10 mL or lower and/or the follicle-stimulating hormone level was greater than 10 IU/L.Results: Among 30 CCS aged 19-41, 12 were identified as having cPH. Factors significantly associated with cPH in CCS included receiving a cyclophosphamide equivalent dose greater than 7.5 g/m2, experiencing secondary cancers, and older age at medical checkup. CCS with cPH exhibited higher fasting blood sugar and elevated luteinizing hormone levels. Furthermore, CCS with cPH reported significantly lower mental component summary scores and reported greater psychological distress.Conclusion: Despite the limited sample size, our preliminary findings suggest that this surveillance approach may help identify male CCS at risk for hypogonadism. These survivors warrant monitoring for gonadal dysfunction and associated complications.","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261438096"},"PeriodicalIF":1.2,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0