Journal of adolescent and young adult oncology最新文献

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Health Knowledge in Adolescent Childhood Cancer Survivors at High Risk for Therapy-Related Cardiotoxicity. 治疗相关心脏毒性高风险青少年儿童癌症幸存者的健康知识。
IF 1.2 4区 医学
Journal of adolescent and young adult oncology Pub Date : 2024-11-07 DOI: 10.1089/jayao.2024.0116
Sanyukta K Janardan, Ann C Mertens, Karen E Effinger
{"title":"Health Knowledge in Adolescent Childhood Cancer Survivors at High Risk for Therapy-Related Cardiotoxicity.","authors":"Sanyukta K Janardan, Ann C Mertens, Karen E Effinger","doi":"10.1089/jayao.2024.0116","DOIUrl":"https://doi.org/10.1089/jayao.2024.0116","url":null,"abstract":"<p><p>Childhood cancer survivors' (CCS) knowledge about late effects can promote positive health behaviors and autonomy. Cardiotoxicity is a major source of morbidity, which can be mitigated through exercise. Descriptive and Fisher's exact statistics were used to characterize health knowledge and physical activity in CCS ≥13 years at high risk for cardiotoxicity. Of 16 CCS (mean age 17.0 ± 2.1 years), 3 (18.8%) identified previous anthracycline exposure, and 5 (31.2%) had adequate physical activity. Of survivors <18 years, 82% had poor late effects knowledge (<i>p</i> = 0.005). Knowledge was not associated with physical activity (<i>p</i> = 0.60). Interventions are needed to improve late effects knowledge in adolescent CCS.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Substance Use in Adolescent and Young Adult Cancer Survivors: An Integrative Review. 青少年和年轻成人癌症幸存者的药物使用情况:综合评论》。
IF 1.2 4区 医学
Journal of adolescent and young adult oncology Pub Date : 2024-10-31 DOI: 10.1089/jayao.2024.0114
Therese Igharas, Ashley Martinez, Joyce E Dains
{"title":"Substance Use in Adolescent and Young Adult Cancer Survivors: An Integrative Review.","authors":"Therese Igharas, Ashley Martinez, Joyce E Dains","doi":"10.1089/jayao.2024.0114","DOIUrl":"10.1089/jayao.2024.0114","url":null,"abstract":"<p><p>The adolescent and young adult (AYA) ages are a time when individuals are susceptible to risky behaviors, including binge drinking, tobacco, marijuana, and illicit drug use. AYAs are at an increased risk for developing chronic health problems compared with their healthy peers, and substance use can pose additional risks. The purpose of this review is to compare substance use in AYAs with their healthy peers and identify contributing factors. A literature search was conducted of PubMed, Scopus, and OVID databases using keywords substance*, adolescent*, adolescence*, teens*, teenager*, young adult*, pediatric*, childhood*, cancer*, and oncology*. The initial search yielded 148 articles. Inclusion criteria specified English language and articles from January 1, 2013, to December 31, 2023. Studies were excluded if they did not include participants aged <18 years and without a noncancer comparison group. Five relevant articles were included after review and appraisal. Substance use was examined by substance use type and contributing factors, including caregiver-AYA relations, age, and depression/coping. Findings were mixed for substance use, including tobacco and alcohol use. Findings indicate no consistent pattern-substance use was both more and less common in AYAs than in their noncancer peers, or substance use did not differ between AYAs and their noncancer peers. With mixed results, each study identified some level of substance use in AYAs. Given this knowledge, when treating AYAs, providers should be diligent about screening for substance use during each visit. AYAs should be educated about the risk of substance use, especially as a vulnerable, at-risk population.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social Reintegration and Stigma Among Childhood Cancer Survivors in West Kenya. 肯尼亚西部儿童癌症幸存者的重返社会与耻辱感。
IF 1.2 4区 医学
Journal of adolescent and young adult oncology Pub Date : 2024-10-30 DOI: 10.1089/jayao.2024.0079
Susan N Mageto, Jesse Pm Lemmen, Festus M Njuguna, Nancy Midiwo, Sandra C Langat, Terry A Vik, Gertjan Jl Kaspers, Saskia Mostert
{"title":"Social Reintegration and Stigma Among Childhood Cancer Survivors in West Kenya.","authors":"Susan N Mageto, Jesse Pm Lemmen, Festus M Njuguna, Nancy Midiwo, Sandra C Langat, Terry A Vik, Gertjan Jl Kaspers, Saskia Mostert","doi":"10.1089/jayao.2024.0079","DOIUrl":"https://doi.org/10.1089/jayao.2024.0079","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> The population of childhood cancer survivors in low- and middle-income countries is set to increase due to diagnosis and treatment advancements. However, cancer is still associated with stigma that may hinder societal re-entry. This study explores the social reintegration and stigmatization of Kenyan childhood cancer survivors to develop targeted interventions for follow-up care. <b><i>Methods:</i></b> Adult survivors of childhood cancers who completed treatment at the largest referral hospital in Western Kenya were interviewed using semi-structured questionnaires between 2021 and 2022. Stigma was assessed using the Social Impact Scale. <b><i>Results:</i></b> Twenty-six survivors (median age 20 years) were interviewed, with 16 (62%) being males. All survivors missed classes during treatment, and 16 (62%) had to repeat school grades after treatment completion. Many (13; 50%) reported negative feelings about the situation at school. Six (23%) were excluded from school activities and four were bullied (15%). Most 25 (96%) could not openly speak about cancer to all community members. Reasons for lacking social support, avoidance, and discrimination were cancer is a curse, contagious, or inheritable. Nine (35%) felt that their marital prospects were negatively affected by their cancer history. Stigma was higher for survivors who received a negative response after cancer disclosure (<i>p</i> = 0.001) and survivors with negative perspectives on their marital prospects (<i>p</i> = 0.002). Survivors recommended community and school education, peer support groups, and counseling. <b><i>Conclusion:</i></b> Childhood cancer survivors in Kenya face difficulties with social reintegration and stigmatization. Outreach campaigns focusing on education at schools and communities should be implemented. Counseling and support groups may facilitate re-entry into society.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility Trial of an Online Expressive Writing Intervention for Young Adult Cancer Survivors. 针对年轻成人癌症幸存者的在线表达性写作干预的可行性试验。
IF 1.2 4区 医学
Journal of adolescent and young adult oncology Pub Date : 2024-10-28 DOI: 10.1089/jayao.2023.0187
Lilian J Shin-Cho, Lenna Dawkins-Moultin, Eunju Choi, Minxing Chen, Carlos H Barcenas, Michael Roth, Yisheng Li, Qian Lu
{"title":"Feasibility Trial of an Online Expressive Writing Intervention for Young Adult Cancer Survivors.","authors":"Lilian J Shin-Cho, Lenna Dawkins-Moultin, Eunju Choi, Minxing Chen, Carlos H Barcenas, Michael Roth, Yisheng Li, Qian Lu","doi":"10.1089/jayao.2023.0187","DOIUrl":"https://doi.org/10.1089/jayao.2023.0187","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Many young adult (YA) breast cancer survivors (BCS) experience psychosocial distress during and after treatment, but do not utilize supportive care resources to maximize their health outcomes. The purpose of this pilot study was to test the feasibility and acceptability of a brief, internet-based expressive writing (EW) intervention intended to improve psychosocial health among YA BCS. <b><i>Methods:</i></b> Thirty YA BCS were remotely recruited via a hospital patient database and randomly assigned to the EW (<i>n</i> = 20) or neutral writing (<i>n</i> = 10) group. The EW intervention included delivery of positive messages and a weekly 30-minute EW activity for 3 weeks. Feasibility, acceptability, patient-reported satisfaction, and health outcomes were evaluated at baseline and 1-month follow-up. <b><i>Results:</i></b> The database-focused recruitment strategies (40% response) appeared to be feasible. Almost all (93%) participants adhered to at least one writing task and 67% to at least two writing tasks. Participants perceived the study as enjoyable and helpful for reducing stress. The difference in QOL of the intervention versus control group was medium to large (d = 0.73). <b><i>Conclusion:</i></b> This is the first study to test the feasibility of an internet-based EW for YA BCS. The online EW pilot intervention demonstrated evidence of feasibility and acceptability to YA BCS; its potential to improve health outcomes should be evaluated in an adequately powered prospective randomized controlled trial (RCT). Online EW may be offered to YA BCS in low-resource settings to address their unique physical and psychological challenges.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Availability of Adolescent and Young Adult-Specific Sexual and Reproductive Health Programs and Resources: A Review of the Websites of National Cancer Institute-Designated Cancer Centers. 青少年和年轻成人性健康和生殖健康计划及资源的可用性:国家癌症研究所指定癌症中心网站回顾。
IF 1.2 4区 医学
Journal of adolescent and young adult oncology Pub Date : 2024-10-28 DOI: 10.1089/jayao.2024.0118
Louise Adillon, Juliann M Stalls, Uyen Nguyen, Isabella Liu, Sarah S Arthur, Rebecca A Shelby, Cheyenne Corbett, Caroline S Dorfman
{"title":"Availability of Adolescent and Young Adult-Specific Sexual and Reproductive Health Programs and Resources: A Review of the Websites of National Cancer Institute-Designated Cancer Centers.","authors":"Louise Adillon, Juliann M Stalls, Uyen Nguyen, Isabella Liu, Sarah S Arthur, Rebecca A Shelby, Cheyenne Corbett, Caroline S Dorfman","doi":"10.1089/jayao.2024.0118","DOIUrl":"https://doi.org/10.1089/jayao.2024.0118","url":null,"abstract":"<p><p>Adolescent and young adult (AYA) cancer survivors often search online for information about cancer-related sexual and reproductive health concerns. A review of the websites of National Cancer Institute-designated cancer centers (<i>n</i> = 9) and comprehensive cancer centers (<i>n</i> = 58) was conducted to identify the presence of AYA-specific sexual and reproductive health programming and resources. No AYA-specific sexual health programs were found. Oncofertility programs were presented on 56% (<i>n</i> = 5) of cancer centers and 50% (<i>n</i> = 29) of comprehensive cancer center websites. As the population grows, it is imperative that cancer centers provide services to meet AYAs' sexual and reproductive health needs and highlight these services on their websites.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Informing Psychosocial Care for Young Couples Coping with Early-Onset Breast Cancer: A Cross-Sectional Examination of Unmet Service Needs and Their Association with Psychological Distress in the First Year Post-Diagnosis. 为应对早发乳腺癌的年轻夫妇提供社会心理护理:对未满足的服务需求及其与确诊后第一年心理困扰的关系的横断面研究。
IF 1.2 4区 医学
Journal of adolescent and young adult oncology Pub Date : 2024-10-25 DOI: 10.1089/jayao.2024.0002
Chiara Acquati, Kristin Cotter-Mena, Chelsea Sanchez, Amy LaMarca-Lyon, Anao Zhang, Michael Roth
{"title":"Informing Psychosocial Care for Young Couples Coping with Early-Onset Breast Cancer: A Cross-Sectional Examination of Unmet Service Needs and Their Association with Psychological Distress in the First Year Post-Diagnosis.","authors":"Chiara Acquati, Kristin Cotter-Mena, Chelsea Sanchez, Amy LaMarca-Lyon, Anao Zhang, Michael Roth","doi":"10.1089/jayao.2024.0002","DOIUrl":"https://doi.org/10.1089/jayao.2024.0002","url":null,"abstract":"<p><p><b><i>Objective:</i></b> Young women diagnosed with breast cancer report greater psychological and physical morbidity than both older women and healthy peers. Similarly, young partners experience elevated cancer-related distress. Psychosocial oncology programs are not frequently attuned to the needs of young adult patients and may exclude their social networks. This marks a critical gap in psychosocial care delivery. The study investigated unmet service needs, psychological distress, and care preferences of young couples managing breast cancer in the first year post-diagnosis. <b><i>Methods:</i></b> Forty dyads (<i>n</i> = 80) of women aged 18-45 and their partners completed measures of anxiety (Generalized Anxiety Disorder-7), depression (Patient Health Questionnaire-9), and a service use questionnaire adapted from previously published Adolescent and Young Adult (AYA) literature. The resulting 25 items assessed perceived care needs and service utilization across three domains: informational, emotional/supportive, and practical issues. Descriptive statistics, cross-tabulations, and bivariate correlations were computed. Actor and partner effects of unmet needs on mental health outcomes were investigated with generalized estimating equations (GEE). <b><i>Results:</i></b> Patients and partners were in their late thirties, mostly non-Hispanic White, married, highly educated, and employed. Approximately 60% of patients and 43%-66% of partners presented one or more unmet service needs, which correlated with greater distress. Unmet needs about information related to exercise, recurrence, nutrition, and symptom management were prevalent. Unmet supportive service needs of both patients and partners included age-appropriate programs, sexual health, and family counseling. Women reported practical needs for work/school accommodations, integrative care, financial issues and health coverage; while financial concerns, health insurance, and caregiving demands were priorities for partners. <b><i>Conclusion:</i></b> Young couples facing early-onset breast cancer experience large proportions of unmet service needs. These challenges were exacerbated by the lack of developmentally targeted psychosocial programs pertaining to informational, supportive, and practical care needs. Enhancing providers' understanding of the psychosocial issues affecting young couples' well-being, and the implementation of systematic procedures to detect and respond to their distress, is urgently needed.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations Between Characteristics of Adolescent and Young Adult Cancer Survivors and Their Use of Different Social Media Platforms: An Observational Study of Social Media Accounts. 青少年和青年癌症幸存者的特征与他们使用不同社交媒体平台之间的关联:社交媒体账户观察研究》。
IF 1.2 4区 医学
Journal of adolescent and young adult oncology Pub Date : 2024-10-22 DOI: 10.1089/jayao.2023.0159
Katja Reuter, Michael Leyderman, Eric P Billinson, Josh F Wallace, Meghan Moran, Joel Milam
{"title":"Associations Between Characteristics of Adolescent and Young Adult Cancer Survivors and Their Use of Different Social Media Platforms: An Observational Study of Social Media Accounts.","authors":"Katja Reuter, Michael Leyderman, Eric P Billinson, Josh F Wallace, Meghan Moran, Joel Milam","doi":"10.1089/jayao.2023.0159","DOIUrl":"10.1089/jayao.2023.0159","url":null,"abstract":"<p><p><b><i>Background:</i></b> The growing number of adolescent and young adult (AYA) cancer survivors and their unmet needs demand innovative communication and care strategies. This study uses social media data to examine how survivors' demographic and clinical characteristics relate to their social media use. <b><i>Methods:</i></b> Data from 300 AYA cancer survivors on six social media sites (YouTube, Instagram, Facebook, TikTok, Reddit, X/formerly Twitter) were collected between August 2022 and March 2023 and analyzed using descriptive statistics and statistical tests (chi-square, Fisher's exact, Welch, Games-Howell post-hoc, logistic regression). <b><i>Results:</i></b> Significant differences were observed across platforms for mean current age (<i>p</i> < 0.001) and age at diagnosis (<i>p</i> < 0.001). We also found significant associations between social media type used and current age, age at diagnosis, years since diagnosis, and the timing of social media account creation. AYAs who created their social media account post-diagnosis were less likely to use YouTube (<i>p</i> = 0.003) and more likely to use Facebook (<i>p</i> = 0.009). Treatment completion was associated with increased use of platform X (<i>p</i> = 0.004). Non-White individuals in our sample were less likely to use Facebook (<i>p</i> = 0.008). Significant associations were found between observed sex and platform usage (<i>p</i> < 0.001), with males more likely to use Reddit (<i>p</i> < 0.001) and X (<i>p</i> < 0.001). <b><i>Conclusions:</i></b> Significant associations were found between demographic and clinical attributes of AYA cancer survivors and the type of social media they used, suggesting that AYA-specific social media-based interventions should be tailored to subgroup characteristics (e.g., social media type, developmental stage based on age at diagnosis and current age, sex).</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Cervical Cancer and Human Papillomavirus Vaccine Education on Vaccination Perception in University Students: A Quasi-Experimental Controlled Educational Intervention. 宫颈癌和人类乳头瘤病毒疫苗教育对大学生疫苗接种认知的影响:准实验对照教育干预。
IF 1.2 4区 医学
Journal of adolescent and young adult oncology Pub Date : 2024-10-17 DOI: 10.1089/jayao.2024.0121
Ulku Saygili Duzova, Emine Kaplan Serin, Ayse Mutlu, Nuray Ocal, Hatice Akkus, Nebahat Toprak, Derya Ceylan
{"title":"The Effect of Cervical Cancer and Human Papillomavirus Vaccine Education on Vaccination Perception in University Students: A Quasi-Experimental Controlled Educational Intervention.","authors":"Ulku Saygili Duzova, Emine Kaplan Serin, Ayse Mutlu, Nuray Ocal, Hatice Akkus, Nebahat Toprak, Derya Ceylan","doi":"10.1089/jayao.2024.0121","DOIUrl":"https://doi.org/10.1089/jayao.2024.0121","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> The study investigated the impact of cervical cancer and human papillomavirus (HPV) vaccine education on university students' vaccination perceptions. <b><i>Methods:</i></b> This research was conducted with pre- posttest and quasi-experimental design with students enrolled in the department of health services of a university. The sample of the study consisted of 87 students (<i>n</i> = 43 in the intervention group, <i>n</i> = 44 in the control group). Research data were collected between June 29 and July 22, 2022, using the Introductory Information Form and HPV Information Scale. An informative training program about cervical cancer and HPV was applied to the intervention group. This training program was carried out in two separate sessions. In the first session, information was given about the prevalence, pathology, and risk factors of cervical cancer. In the second session, general information about HPV, details about the vaccine, and vaccination programs were given. Training sessions are organized as small group discussions and seminars covering relevant topics. <b><i>Results:</i></b> In our study, the average age of our students was 20.7 ± 2.5 years, and in both groups, the proportion of students who did not know about HPV, which can cause cervical cancer, was quite high (74.4%, 68.2%). The majority of the control and intervention groups needed health education about STDs. There were statistically significant differences between the control and intervention groups in terms of the pre-test and posttest Knowledge of HPV Scale scores (<i>p</i> < 0.05). <b><i>Conclusion:</i></b> It was found that the education on cervical cancer and HPV positively affected the perspectives of the students on vaccination. Interactive and group-oriented education increases knowledge sharing by encouraging interaction among students. In this way, a broader knowledge base about cervical cancer and HPV can be created, and misinformation can be corrected.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rectal Cancer in Young Adults: A Single Center Experience. 年轻人直肠癌:单中心经验
IF 1.2 4区 医学
Journal of adolescent and young adult oncology Pub Date : 2024-10-17 DOI: 10.1089/jayao.2024.0090
Halil Göksel Güzel, Murat Koçer, Mustafa Yıldız, Banu Öztürk, Derya Kıvrak Salim, Mustafa Karaca
{"title":"Rectal Cancer in Young Adults: A Single Center Experience.","authors":"Halil Göksel Güzel, Murat Koçer, Mustafa Yıldız, Banu Öztürk, Derya Kıvrak Salim, Mustafa Karaca","doi":"10.1089/jayao.2024.0090","DOIUrl":"https://doi.org/10.1089/jayao.2024.0090","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Individuals below the age of 40 make up only 3%-11% of colorectal cancer (CRC) cases. In this study, we aimed to review clinicopathological characteristics of rectal cancer in young adults. <b><i>Methods:</i></b> Rectal adenocancer patients aged ≤40 were included in this study from Antalya Training and Research Hospital. A single-arm descriptive study was designed. <b><i>Results:</i></b> There were 85 patients in the final analyses (<i>n</i> = 85). The median age was 37 (19-40). Mucinous adenocarcinoma and signet-cell carcinoma rates were 11.8% for each. Twenty patients (24.4%) had high-grade cancer. Fourteen patients (16.5%) had CRC history in a first-degree relative. None of the patients were diagnosed through a screening test. Of the 85 patients, 41 (48.2%) were stage 3 and 23 (27.1%) were stage 4 at the time of diagnosis. Thirty-four (54.8%) of the 62 nonmetastatic patients had neoadjuvant and 27 (43.5%) had adjuvant treatment because of having an upfront surgery before presentation. In the nonmetastatic population, the 5-year disease-free survival rate was 69.7 ± 6.5%. De-novo metastatic underwent chemotherapy, and biological agents were administered when feasible. KRAS mutation rate was 56.5% among metastatic patients. The median progression-free survival for the first-line treatment was 11.2 months (5.7-16.6), and the median overall survival was 22.3 months (15.4-29.1). <b><i>Conclusion:</i></b> We demonstrated that rectal cancer is usually diagnosed at late stages in young individuals which is compatible with the previous reports. Low cancer awareness in young patients and their caregivers and adverse histological features were advocated as the reason for the diagnostic delay. However, future studies may elucidate the reason behind the common diagnosis at advanced stages.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Planned Immediate Chemotherapy and Cryopreservation of Oocytes or Embryos for Fertility Preservation in Women with Malignancies. 计划立即化疗并冷冻保存卵母细胞或胚胎,以保存恶性肿瘤妇女的生育能力。
IF 1.2 4区 医学
Journal of adolescent and young adult oncology Pub Date : 2024-10-08 DOI: 10.1089/jayao.2023.0180
Ji Yeon Han, Hoon Kim, Yun Soo Hong, Minhee Lee, Soo Jin Han, Seung-Yup Ku
{"title":"Planned Immediate Chemotherapy and Cryopreservation of Oocytes or Embryos for Fertility Preservation in Women with Malignancies.","authors":"Ji Yeon Han, Hoon Kim, Yun Soo Hong, Minhee Lee, Soo Jin Han, Seung-Yup Ku","doi":"10.1089/jayao.2023.0180","DOIUrl":"https://doi.org/10.1089/jayao.2023.0180","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Oocyte and embryo cryopreservation before gonadotoxic treatment are established methods to increase the likelihood of live births. Although several sociodemographic factors were found to be associated with undergoing fertility preservation (FP) treatment, clinical characteristics such as planned immediate chemotherapy were not fully investigated. We aimed to investigate whether the planned immediate chemotherapy is related to the decision to undergo oocyte/embryo cryopreservation for FP with adjustment for other clinical characteristics. <b><i>Methods:</i></b> This institutional cohort study included 491 premenopausal women aged 19 years or older who visited the FP clinic at a tertiary medical center between 2006 and 2019. The primary outcome was whether the participants underwent oocyte/embryo cryopreservation. We evaluated the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) of undergoing oocyte/embryo cryopreservation according to whether immediate chemotherapy was planned using univariable and multivariable logistic regression. <b><i>Results:</i></b> Women scheduled for immediate chemotherapy were much less likely to undergo oocyte/embryo cryopreservation than women not scheduled for immediate chemotherapy (OR = 0.46, 95% CI 0.27-0.76) in univariable logistic regression analysis. After adjustment for covariates such as marital status, type of malignancies, and calendar year period, women scheduled for immediate chemotherapy were still less likely to undergo oocyte/embryo cryopreservation than women not scheduled for immediate chemotherapy (OR = 0.31, 95% CI: 0.17-0.56). The association was not different according to the type of malignancies (<i>p</i> for interaction = 0.13). Regarding breast cancer, the OR for undergoing oocyte/embryo cryopreservation in women scheduled for immediate chemotherapy was robust compared with those not planned for immediate chemotherapy (OR = 0.25, 95% CI: 0.12-0.53). <b><i>Conclusion:</i></b> The present study demonstrated that planned immediate chemotherapy was negatively associated with undergoing oocyte/embryo cryopreservation. This information can be helpful for FP counseling.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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