Journal of adolescent and young adult oncology最新文献

{"title":"Digital Tools Used to Enhance the Quality of Life and Well-Being of Adolescent and Young Adult Cancer Survivors: A Systematic Review of the Literature.","authors":"Amandine Bertrand, Noémie Escot, Magali Girodet, Thomas Congiusta, Anne Sophie Baudry, Charlotte Demoor, Véronique Christophe","doi":"10.1177/21565333251377393","DOIUrl":"10.1177/21565333251377393","url":null,"abstract":"<p><p>The number of adolescent and young adult cancer survivors (AYACSs) is increasing due to advancements in therapies. Despite these improvements, 70% of survivors experience long-term side effects. This systematic review aims to identify digital tools that enhance the quality of life and well-being of AYACSs aged 15-29 years. The review was conducted using four databases: PubMed, Science Direct, Cochrane, and PsycINFO (OVID platform). Articles from bibliographic references of selected studies were also included if relevant. The search followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines and included studies published between January 2014 and December 2024 that described digital tools focusing on quality of life and/or well-being. Titles and abstracts were independently assessed by two reviewers, with a third reviewer resolving disagreements. The initial search identified 291 articles, updated in December 2024. After screening, 285 articles were excluded for not meeting the inclusion criteria. Three studies met the criteria, focusing on interventions related to information dissemination, physical activity, and psychological support. These studies, conducted in the United States and Australia between 2015 and 2024, included randomized controlled trials with measured outcomes related to quality of life and/or well-being. The findings suggest that digital tools can improve the quality of life of AYACSs, particularly through peer interaction and personalized content. However, the limited number of studies and participants highlights the need for further research. The review also discusses challenges in involving AYACSs in digital programs and suggests optimizing digital tools by promoting peer links, integrating social networks, and considering self-determination theory.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"165-170"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real World Data Identifies Care Needs in Adolescent and Young Adult Patients with Lymphoma: A Matched Cohort Study.","authors":"John Mariano, Myla Strawderman, Eric Snyder, Tina Faugh, Danielle S Wallace, Clive S Zent, Paul Barr, Patrick M Reagan, Jonathan W Friedberg, Carla Casulo","doi":"10.1177/21565333251370939","DOIUrl":"10.1177/21565333251370939","url":null,"abstract":"<p><strong>Purpose: </strong>Adolescent and young adult (AYA) cancer patients have unique nononcologic challenges compared to adult and pediatric counterparts. National guidelines highlight unmet care needs in mental, physical, and sexual/reproductive health domains. We present a single institution retrospective matched cohort study exploring the feasibility of using electronic medical record (EMR) to identify nononcologic domains correlating to unmet care needs in AYA patients with lymphoma compared with matched controls.</p><p><strong>Methods: </strong>AYA patients with lymphoma from 2014 to 2020 were compared to age/sex matched controls without cancer. The groups were queried using a novel EMR assessment prior to diagnosis and during the 1-year period after diagnosis. Prevalence and incidence of nononcologic care domains were compared.</p><p><strong>Results: </strong>Patients with lymphoma had higher rates of chronic pain and analgesic use (15% vs. 1%, <i>p</i> < 0.0001, and 60.84% vs. 29.33% <i>p</i> < 0.0001) prior to diagnosis and more fertility preservation appointments compared to controls. One year after diagnosis, there were higher rates of anxiety (29% vs. 21%, <i>p</i> < 0.017), antidepressant use (26% vs. 14%, <i>p</i> < 0.0003), opioid abuse (4% vs. 0.69%, <i>p</i> < 0.007), chronic pain (15% vs. 1%, <i>p</i> < 0.0001), analgesic use (80% vs. 13%, <i>p</i> < 0.0001), influenza vaccination (16% vs. 0.69% <i>p</i> < 0.0001), and reproductive endocrinology and infertility appointments (21.7% vs. 1%, <i>p</i> < 0.0001) in the lymphoma group.</p><p><strong>Conclusion: </strong>EMR can feasibly track institutional-level nononcologic care domains in AYA patients to frame development of institution-specific interventional studies to address care gaps and design prospective patient surveys to correlate to patient-identified concerns.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"171-178"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Why Would You Say That? That Is the Worst Thing You Could Possibly Say\": Communication Work Among Young Breast Cancer Survivors.","authors":"Laura E Miller","doi":"10.1177/21565333251376241","DOIUrl":"10.1177/21565333251376241","url":null,"abstract":"<p><strong>Purpose: </strong>Communication is a salient aspect of coping with cancer. Research suggests that young adult cancer survivors may experience unique challenges, including social isolation, fertility and family planning concerns, dating and marriage, and financial challenges. Little is known, however, about the types of communicative work young breast cancer survivors face.</p><p><strong>Methods: </strong>A total of 25 young breast cancer survivors between the ages of 18 and 39 participated in semi-structured interviews. The average age of the participants at the time of diagnosis was 34 (range = 26-39 years). Constant comparative analytic methods revealed themes relating to the types of communication work participants experienced.</p><p><strong>Results: </strong>Communication work was common among the participants. Specifically, the data revealed various types of communication work, including information work, relational work, emotion work, identity work, and coordination work.</p><p><strong>Conclusions: </strong>Communicative work persisted throughout breast cancer survivorship. Breast cancer survivors' loved ones should be cognizant of such challenges to promote empathic conversations across the cancer trajectory.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"205-211"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent and Young Adult Cancer Patient Characteristics and Palliative Care Trends in an Asian Tertiary Cancer Center.","authors":"You Kai Poh, Shi Yun Giovanna Wong, Dai Lin Goh, Yu Ke, Victoria Hwei May Wong","doi":"10.1177/21565333251386711","DOIUrl":"10.1177/21565333251386711","url":null,"abstract":"<p><strong>Purpose: </strong>Adolescent and young adult oncology patients represent a unique group with complex needs, yet data on palliative care utilization remain scarce in the Asian population. The definition of this group remains heterogeneous across organizations, and it is unclear whether extending the age range beyond conventional cutoffs affects observed patterns of care. We conducted a retrospective cohort study to describe palliative care utilization and end-of-life outcomes among oncology patients aged 16-45 years at a tertiary cancer center in Singapore.</p><p><strong>Methods: </strong>Oncology patients aged 16-45 referred to the palliative team from 2011 to 2021 were identified using institutional databases. Chi-square tests and sensitivity analysis were used to compare outcomes across age groups. The timing of last treatment relative to palliative referral was described. Multivariable logistic regression was performed to identify predictors of aggressive care.</p><p><strong>Results: </strong>Median age was 37 years; 58.8% were female; 83.6% of patients were deceased at the time of study. There was a trend toward earlier referrals in recent years, including during the COVID-19 pandemic. Outcomes including cause of death, place of death, rates of early/late referral, and aggressive care did not differ significantly across age groups. Timing of referral was the key independent factor associated with poor end-of-life outcomes including aggressive treatment.</p><p><strong>Conclusion: </strong>Referral patterns and end-of-life care intensity are consistent across ages through 45 years. Late palliative referrals were associated with higher usage of aggressive treatment and death in hospital. Findings support integrated, timely access to palliative care in this group and validate flexibility in the definition of age ranges.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"212-219"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition of Childhood Cancer Survivors into Adult Health Care: A Perspective from Adult Care.","authors":"Tomoko Katsui Taniyama, Akiko Higuchi, Midori Kadowaki, Shinji Mochizuki, Hideko Uryu, Takeshi Inagaki, Hajime Oishi, Miyuki Sadatsuki, Akiyo Tanabe, Makiko Hashimoto, Shuji Kubota, Daisuke Katagiri, Chikako Kiyotani, Kimikazu Matsumoto, Chikako Shimizu","doi":"10.1177/21565333251372457","DOIUrl":"10.1177/21565333251372457","url":null,"abstract":"<p><strong>Purpose: </strong>The number of long-term childhood cancer survivors (CCSs) has been increasing, and the importance of transitioning from pediatric to adult care has been advocated. This study aimed to describe the health problems of adult CCSs from adult-care perspectives.</p><p><strong>Methods: </strong>We conducted a chart review of adult CCSs aged ≥18 years who visited a transition clinic in adult care between June 2019 and March 2024.</p><p><strong>Results: </strong>The study included 25 CCSs, with a median follow-up period of 14 months. The median number of medical departments requiring regular clinic visits was three (range 1-7). Among the participants, 15 (60%) had at least one severe health problem (grade 3 or higher). Notably, 45% (5 of 11) of participants with cardiovascular disease and 64% (9 of 14) of those with bone mineral density (BMD) deficiency were diagnosed after transition. During the follow-up period, 13 CCSs were hospitalized in the adult ward. Additionally, 52% (13 of 25) of the CCSs requested psychosocial intervention. Five CCSs who had health problems such as pituitary insufficiency, hearing loss, and visual impairment needed ongoing support from social workers.</p><p><strong>Conclusion: </strong>Adult CCSs present with multiple health problems and risks. Because the health care system is different between adult care and pediatric care, comprehensive re-evaluation of health problems and care optimization from the adult-care perspective is important for the successful transition of CCSs to adult care.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"196-204"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recapturing Life: Virtual Peer-Based Psychological Support for Adolescent and Young Adult Cancer Survivors Delivered in the Community.","authors":"Elin Irestorm, Claire E Wakefield, Kate Hetherington, Brittany C McGill, Holly E Evans, Fiona McDonald, Pandora Patterson, Annette Beattie, Richard J Cohn, Ursula M Sansom-Daly","doi":"10.1177/21565333251369689","DOIUrl":"10.1177/21565333251369689","url":null,"abstract":"<p><strong>Purpose: </strong>Adolescent and young adult (AYA) cancer survivors have unique psychological needs and require tailored support, as they transition from hospital settings following cancer treatment. This study aimed to evaluate the safety and clinical effectiveness of the online \"Recapture Life\" program to improve AYA aged survivors' psychological adjustment in early cancer survivorship.</p><p><strong>Methods: </strong>The intervention was delivered in community settings, by trained psychosocial staff at partnering cancer-support organizations. The participants received seven cognitive behavioral therapy-based online sessions six weekly 90-minute group sessions and a booster session. A pre-post design was used, where participants completed patient-reported outcome measures at intake, and 6 months after intervention completion. Measures assessed psychological distress, cancer-related problems, peer support, and program benefit/burden.</p><p><strong>Results: </strong>Thirty 13-39-year-olds with mixed cancer diagnoses (mean time since diagnosis 2.9 years) completed both assessments. We did not find evidence that the intervention reduced psychological distress. However, 6 months after completing Recapture Life, AYAs reported fewer cancer-related problems (<i>t</i>(29) = 2.63, <i>p</i> = 0.003) and improved peer support (<i>t</i>(29) = 8.04, <i>p</i> = 0.015), with medium effect sizes. Most participants reported no program burden (72%) and found Recapture Life at least somewhat beneficial (79%). Most (73%) reported staying in contact with AYAs from their group post-intervention.</p><p><strong>Conclusion: </strong>Six months after completing Recapture Life, AYAs reported having more peer support and fewer cancer-related problems. This study addresses a well-documented gap in psychological services tailored to AYA survivors' needs. Recapture Life delivered in the community addressed areas of concern for the AYAs and may teach adaptive skills for survivors adjusting to life after cancer treatment.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"187-195"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Characteristics of Psychiatric Disorders in Adolescent and Young Adult Patients with Malignant Brain Tumors.","authors":"Eun Sang Yi, Yunseop Kim, Chaeeun Cho, Jimin Kim, O Kyu Noh, Jun Eun Park","doi":"10.1177/21565333251386716","DOIUrl":"10.1177/21565333251386716","url":null,"abstract":"<p><strong>Purpose: </strong>Adolescents and young adults (AYAs) with brain tumors are at an increased risk of developing psychiatric disorders. We aimed to investigate the incidence and characteristics of psychiatric disorders in AYA patients with brain tumors.</p><p><strong>Methods: </strong>Using the Korean Classification of Diseases, we identified a cohort of AYA patients (aged 15-34 years) diagnosed with malignant brain neoplasms (C71) between 2003 and 2016 from the Korean National Health Insurance Claims Database. The analysis included 7052 patients.</p><p><strong>Results: </strong>The 10-year cumulative incidence rate of psychiatric disorders was 21.5%. The most common psychiatric disorders were neurotic, stress-related, and somatoform disorders (11.4%), followed by mood (affective) disorders (9.4%). Factors associated with a higher incidence of psychiatric disorders included female sex (hazard ratio [HR] 1.16, 95% confidence interval [CI]: 1.05-1.28, <i>p</i> = 0.005), history of seizures (HR: 1.47, 95% CI: 1.31-1.66, <i>p</i> < 0.001), and brain tumor diagnosis during the latter part of the study period (HR: 1.14, 95% CI: 1.03-1.27, <i>p</i> = 0.010). Psychiatric hospital admissions were most frequent among patients with schizophrenia, schizotypal disorders, and delusional disorders (<i>n</i> = 5). The most common psychiatric disorders requiring psychotherapy were neurotic, stress-related, and somatoform (<i>n</i> = 580) and mood (<i>n</i> = 526) disorders.</p><p><strong>Conclusion: </strong>A significant number of AYA patients with brain tumors develop psychiatric disorders after diagnosis, and most require treatment. Early detection through screening programs and personalized psychological support during and after cancer treatment may improve the mental health and quality of life of AYA patients with brain tumors.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"179-186"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics of Adolescent and Young Adult Patients Undergoing Pancreatectomy for Malignant Tumors: A 20-Year Single Institution Experience.","authors":"Naonori Kawakubo, Minoru Esaki, Satoshi Nara, Akinori Miyata, Takahiro Mizui, Ryosuke Umino, Junkichi Takemoto, Tomoro Hishiki, Akihiro Yoneda","doi":"10.1177/21565333251394590","DOIUrl":"10.1177/21565333251394590","url":null,"abstract":"<p><strong>Background and aim: </strong>Adolescent and young adult (AYA) patients who require pancreatectomy are rare. There are few reports concerning the characteristics of AYA patients undergoing pancreatectomy for malignant tumors. This study aimed to clarify the characteristics and outcomes of AYA patients who had undergone pancreatectomy.</p><p><strong>Methods: </strong>AYA patients (age 15-35 years) who underwent pancreatectomy at our institution between 1995 and 2018 were included in this study. The diagnosis, operative procedure, complications, mortality, and survival were retrospectively analyzed.</p><p><strong>Results: </strong>Forty-seven patients underwent pancreatectomy (median age 29 years; range, 16-35 years). The diagnoses were solid-pseudopapillary neoplasm (SPN; <i>n</i> = 21 [44.6%]), neuroendocrine neoplasm (NEN; <i>n</i> = 12 [25.5%]), adenocarcinoma (<i>n</i> = 5 [10.6%]), and others (<i>n</i> = 9 [19.1%]). The surgical procedures included pancreatoduodenectomy (PD; <i>n</i> = 17 [36.1%]), distal pancreatectomy (DP; <i>n</i> = 18 [38.2%]), middle pancreatectomy (<i>n</i> = 8 [17.0%]), and tumor enucleation (<i>n</i> = 4 [8.5%]). The most common postoperative complication was pancreatic fistula (POPF) (<i>n</i> = 29 [61.7%]). Hemorrhage was noted in one case, but the surgical mortality rate was 0%. Long-term complications included four cases of pancreatitis, three cases of diabetes, two cases of bowel obstruction, and one case of cholangitis. The 5-year recurrence-free-survival (RFS) and overall-survival (OS) rates in patients with SPN/NEN/others were 91.8% and 97.5%, respectively. In contrast, the 5-year RFS and OS rates in patients with adenocarcinoma were 53.3% and 80.0%, respectively.</p><p><strong>Conclusion: </strong>Most AYA patients who underwent pancreatectomy had low-grade malignancies and showed a favorable survival. Although POPF and pancreatitis frequently occur, radical surgery-even major pancreatectomy such as PD and DP-is feasible and effective in AYA patients with malignant tumors.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"220-225"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a Tool to Assess Needs of AYA Cancer Survivors in Rural, Medically Underserved Regions of Southwestern Indiana.","authors":"Brittany J Ritzman, Joseph Sakel, Ryan Heumann, Oseme Okoruwa, Bridget Hawryluk, Courtney Moore, Lisa Parks, Brandon Cockrum, Dustin Lynch, Andrea Kiser, Sarah Wiehe, Kara Garcia, Tammy Sajdyk","doi":"10.1177/21565333251405138","DOIUrl":"10.1177/21565333251405138","url":null,"abstract":"<p><p>While cancer has sustained impacts on survivors, no unified strategy exists to assess the ongoing needs of survivors. Adolescent and young adult (AYA) cancer survivors have unique needs and concerns related to their life stages, including education, career, relationships, and family planning, all of which may be impacted by cancer and its treatments. In this study, we co-designed with survivors a distributable digital tool for assessing needs among this population. Because of known disparities in outcomes for survivors in rural or medically underserved areas, initial tool development focused on feedback from AYA survivors in one such region (Southwest Indiana).</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"226-231"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145833981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trunk Muscle Mass Changes During Chemotherapy in Children and Adolescents with Lower-Limb Osteosarcoma: A Retrospective Study Comparing Surgical Procedures.","authors":"Masahiro Aoki, Megumi Toki, Takanori Murakami, Makoto Emori","doi":"10.1177/21565333261449926","DOIUrl":"https://doi.org/10.1177/21565333261449926","url":null,"abstract":"<p><strong>Purpose: </strong>To examine longitudinal changes in trunk muscle mass during chemotherapy in children and adolescents with lower-limb osteosarcoma and to compare these changes according to surgical procedure.</p><p><strong>Methods: </strong>Medical records of 11 patients admitted to a university hospital in Japan between 2010 and 2023 were analyzed. Trunk muscle mass was assessed using computed tomography scans of the L3 vertebral body using the VINCENT^® abdominal analysis system. Changes in trunk muscle mass from admission to discharge were categorized as increase (≥5%), maintenance (±5%), or decrease (≤-5%). Rehabilitation-related variables and surgical procedures were examined in relation to muscle mass changes.</p><p><strong>Results: </strong>The mean age was 13.7 years (eight males and three females). Seven patients underwent limb-sparing surgery, and four underwent amputation. No significant associations were observed between rehabilitation-related variables (hospitalization duration, rehabilitation frequency, or session duration) and trunk muscle mass changes. However, a significant association was identified between surgical procedure and trunk muscle mass changes. All patients who underwent amputation maintained or increased muscle mass, whereas five of the seven patients who underwent limb-sparing surgery experienced a decrease.</p><p><strong>Conclusion: </strong>In this retrospective observational study, trunk muscle mass changes during chemotherapy were associated with the type of surgical procedure but not with rehabilitation-related variables. Further studies with larger sample sizes are warranted to better understand factors associated with muscle mass changes in this population.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261449926"},"PeriodicalIF":1.2,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}