Journal of adolescent and young adult oncology最新文献

{"title":"Availability of Adolescent and Young Adult-Specific Sexual and Reproductive Health Programs and Resources: A Review of the Websites of National Cancer Institute-Designated Cancer Centers.","authors":"Louise Adillon, Juliann M Stalls, Uyen Nguyen, Isabella Liu, Sarah S Arthur, Rebecca A Shelby, Cheyenne Corbett, Caroline S Dorfman","doi":"10.1089/jayao.2024.0118","DOIUrl":"10.1089/jayao.2024.0118","url":null,"abstract":"<p><p>Adolescent and young adult (AYA) cancer survivors often search online for information about cancer-related sexual and reproductive health concerns. A review of the websites of National Cancer Institute-designated cancer centers (<i>n</i> = 9) and comprehensive cancer centers (<i>n</i> = 58) was conducted to identify the presence of AYA-specific sexual and reproductive health programming and resources. No AYA-specific sexual health programs were found. Oncofertility programs were presented on 56% (<i>n</i> = 5) of cancer centers and 50% (<i>n</i> = 29) of comprehensive cancer center websites. As the population grows, it is imperative that cancer centers provide services to meet AYAs' sexual and reproductive health needs and highlight these services on their websites.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"283-289"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Knowledge in Adolescent Childhood Cancer Survivors at High Risk for Therapy-Related Cardiotoxicity.","authors":"Sanyukta K Janardan, Ann C Mertens, Karen E Effinger","doi":"10.1089/jayao.2024.0116","DOIUrl":"10.1089/jayao.2024.0116","url":null,"abstract":"<p><p>Childhood cancer survivors' (CCS) knowledge about late effects can promote positive health behaviors and autonomy. Cardiotoxicity is a major source of morbidity, which can be mitigated through exercise. Descriptive and Fisher's exact statistics were used to characterize health knowledge and physical activity in CCS ≥13 years at high risk for cardiotoxicity. Of 16 CCS (mean age 17.0 ± 2.1 years), 3 (18.8%) identified previous anthracycline exposure, and 5 (31.2%) had adequate physical activity. Of survivors <18 years, 82% had poor late effects knowledge (<i>p</i> = 0.005). Knowledge was not associated with physical activity (<i>p</i> = 0.60). Interventions are needed to improve late effects knowledge in adolescent CCS.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"265-269"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives of Young Women with Breast Cancer: Patient Experiences Indicate Opportunities to Improve Treatment.","authors":"Sara P Myers, Jaime Gilliland, Shari B Goldfarb, Mary L Gemignani","doi":"10.1089/jayao.2024.0045","DOIUrl":"10.1089/jayao.2024.0045","url":null,"abstract":"<p><p>In this focus group study of 11 women younger than 45 years of age treated at Memorial Sloan Kettering Cancer Center (New York, NY, USA) between March 2020 and April 2021, patients were asked about their preferences for types of resources, and timing and method of information delivery. Patients expressed interest in personalized medicine, access to integrative health and a holistic approach to treatment, and early consultation for fertility preservation. Their narratives elaborated on how age at diagnosis influences interpersonal relationships and quality of life, and provides direction for interventions to better counsel and support this population.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"275-282"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Determinants of 6-Mercaptopurine Adherence Among Patients with Acute Lymphoblastic Leukemia/Lymphoma: A Cross-Sectional Analysis.","authors":"Ayah El-Khatib, Kevin Matos, Jenna Rossoff, Alexandra Psihogios","doi":"10.1089/jayao.2024.0119","DOIUrl":"10.1089/jayao.2024.0119","url":null,"abstract":"<p><p>Acute lymphoblastic leukemia requires around 18 months of daily oral chemotherapy called 6-mercaptopurine (6-MP) for treatment. Previous research has included a broad age range and shows adolescent/young adult (AYA) age and minoritized race/ethnicity are associated with lower adherence. Few studies have evaluated how these intersecting identities impact adherence. In a retrospective analysis of an AYA sample, we evaluated the relationships between race/ethnicity, area deprivation index (ADI), and insurance with electronically monitored 6-MP adherence. Results showed minoritized race/ethnicity and ADI correlated with adherence. Findings highlight the need for equitable interventions that enhance adherence and improve outcomes among AYAs.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"270-274"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited Recommendations and Evidence for Timing and Frequency of Anti-Mullerian Hormone Screening in Female Pediatric Cancer Survivors: A Systematic Review from the Pediatric and Adolescent Committee of the Oncofertility Consortium.","authors":"Seth J Rotz, Kari Bjornard, Karen Hampanda, Allison Kumnick, Jacqueline C Yano Maher, Christine Yu, Leslie Appiah","doi":"10.1089/jayao.2024.0111","DOIUrl":"10.1089/jayao.2024.0111","url":null,"abstract":"<p><p>Guidelines regarding the optimal use and timing of anti-Mullerian hormone (AMH) screening in childhood cancer survivors to evaluate for the risk of premature ovarian insufficiency or reduced fertility potential are lacking. We conducted a systematic review of the current evidence supporting AMH screening of female childhood cancer survivors with the overall objective to identify gaps in the literature needing further study, to allow for future data-driven recommendations. Search terms included \"cancer, fertility, and anti-Mullerian hormone.\" We included original research articles that had ≥20 female childhood cancer survivors and excluded studies not including pediatric oncology survivors (≤18 years of age), did not include raw AMH values, were a mixed pediatric/young adult population which were minority pediatric, or did not separate pediatric from adult AMH data. In total, 17 studies (8 case-control, 5 cross-sectional, and 4 longitudinal prospective cohorts), encompassing 1106 total survivors met inclusion criteria and were further evaluated. Three studies evaluated the relationship of AMH to antral follicle count with generally good concordance. Four studies analyzed longitudinal changes in AMH with chemotherapy demonstrating that most patients will have an acute drop in AMH during therapy, and recovery of AMH over time is dependent on treatment intensity. No studies evaluated the optimal timing or interval of AMH testing. AMH correlates well with other markers of ovarian reserve, but there is insufficient data regarding the utility of AMH to predict the ability to conceive or timing of menopause. Optimal AMH screening initiation, duration, and intervals also require further study.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"212-219"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Survey on the Status of Embryo Freezing for Fertility Preservation in Japan.","authors":"Tadashi Okimura, Hiroyuki Tomari, Osamu Okitsu, Satoshi Mizuno, Hiroyuki Kikuchi, Akiko Yabuuchi, Sayako Furuyama, Ken Taniguchi, Isao Tamura, Kuniaki Ota, Yusuke Fukuda, Yuki Horage, Nao Suzuki","doi":"10.1089/jayao.2025.0017","DOIUrl":"https://doi.org/10.1089/jayao.2025.0017","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> No studies regarding embryo freezing as a technique for preserving fertility among patients with cancer have been conducted in Japan. Hence, we surveyed embryologists working at fertility preservation facilities to investigate the current status of embryo freezing for fertility preservation in patients with cancer in Japan. <b><i>Methods:</i></b> Embryologists from 622 institutions registered for <i>in vitro</i> fertilization and embryo transfer with the Japan Society of Obstetrics and Gynecology were surveyed online about their embryo freezing practices. <b><i>Results:</i></b> The survey revealed that 352 institutions perform embryo freezing for general assisted reproduction, while only 178 (50.6%) do so for fertility preservation. About 23.0% use different criteria or personnel for cryopreservation based on purpose, 15.2% freeze pronuclear stage embryos, 84.3% freeze cleavage stage embryos, and 92.7% freeze blastocyst stage embryos. All institutions use vitrification, and over 90% follow the manufacturer's protocol for freezing and thawing. <b><i>Conclusions:</i></b> Fertility preservation through embryo freezing is not widely used in Japan, and there is inadequate data on the therapy's current status and results for patients with cancer. Further research is necessary to provide patients with cancer with the opportunity to preserve their fertility without major concerns and ultimately enhance their quality of life after treatment.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Impact of Sexual Complaints on Depressive Symptoms in Adolescents and Young Adults with Cancer: A Cross-Sectional Sub-Study.","authors":"Line Bentsen, Vera Belgers, Annamaria Giraldi, Annika von Heymann, Christoffer Johansen, Karin Piil, Helle Pappot","doi":"10.1089/jayao.2024.0150","DOIUrl":"https://doi.org/10.1089/jayao.2024.0150","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Adolescents and young adults (AYAs) diagnosed with cancer face unique psychosocial challenges, including sexual complaints. Despite the prevalence of these sexual issues, they are underexplored in AYA oncology care. The aim of this study is firstly to examine the prevalence of sexual complaints among AYAs with cancer across genders, age groups, and types of cancer. Second, we explore the association between sexual complaints and depressive symptoms. <b><i>Methods:</i></b> This cross-sectional sub-study included 305 AYAs (aged 15-39 at diagnosis) actively affiliated with the oncology department at Copenhagen University Hospital-Rigshospitalet. Participants completed questionnaires assessing sexual complaints and depressive symptoms. Sexual problems, distress, satisfaction, and willingness to discuss these issues were analyzed alongside demographic, clinical, and treatment data. Univariate and multivariable regression analyses evaluated associations with depressive symptoms. <b><i>Results:</i></b> Sexual problems affected 63.9% of AYAs, 49.5% experienced sexual distress, and 58.4% were dissatisfied with their sexual lives. Younger AYAs reported higher sexual satisfaction than older AYAs. Sexual distress, dissatisfaction, and reluctance to discuss sexual issues were associated with increased depressive symptoms in the univariate analysis. In the multivariable model, sexual distress remained independently associated with depressive symptoms, alongside age at diagnosis, civil status, cancer type, and pain. <b><i>Conclusion:</i></b> Sexual complaints, particularly distress, are prevalent among AYAs with cancer and are significantly associated with depressive symptoms. Integrating routine discussions about sexual health into oncology care could probably improve mental health outcomes and overall quality of life for this vulnerable group. Future research should focus on targeted interventions to address these interconnected challenges.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Travel Time to Fertility Specialty Care Among Reproductive-Age Cancer Survivors.","authors":"Nidia Rodriguez-Ormaza, Paul L Delamater, Melissa A Troester, Stephanie B Wheeler, Christopher D Baggett, Clare Meernik, Jennifer E Mersereau, Valerie L Baker, Ethan Wantman, Hazel B Nichols","doi":"10.1089/jayao.2024.0023","DOIUrl":"https://doi.org/10.1089/jayao.2024.0023","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Adolescent and young adult (AYA) women facing gonadotoxic cancer treatments are recommended to consider fertility preservation. However, fertility clinics are scarce in number and location. We describe geographic access to fertility clinics in a statewide cancer population. <b><i>Methods:</i></b> This cross-sectional study included 5,632 AYA women from the North Carolina Central Cancer Registry diagnosed with lymphoma, breast, or gynecological cancers who received gonadotoxic treatment during 2004-2015. Geographic access was defined as travel time from patient residence to the nearest fertility clinic at diagnosis. Multivariable logistic regression was used to calculate prevalence odds ratios (POR) and 95% confidence intervals (CIs) for the association between travel time and individual and contextual factors (neighborhood socioeconomic status and rurality). <b><i>Results:</i></b> Mean travel time was 51 ± 42 minutes, and 42% of AYAs lived <30 minutes from a clinic. Black non-Hispanic women, those living in advantaged neighborhoods, metropolitan areas, and privately insured had shorter average travel times. Black non-Hispanic women were more likely to live <30 minutes from a clinic than their white non-Hispanic counterparts (POR = 3.3; 95% CI: 2.8-3.8). Publicly insured (vs privately) AYAs and those living in the most (vs least) deprived neighborhoods were 40% less likely to live within a 30-minute drive (POR for both = 0.6; 95% CI: 0.5-0.7). Compared to metropolitan areas, micropolitan (small city) residents were less likely to live <30 minutes from a clin ic. <b><i>Conclusion:</i></b> The burden of travel time to fertility clinics showed important differences by race and ethnicity, neighborhood SES, insurance, and rurality. The results emphasize the need for tailored and multifaceted strategies to improve access.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triadic Communication-Naming the Third Person.","authors":"Deborah J Critoph, Luke A M Smith, Rachel M Taylor, Helen Hatcher, Alison Finch, Robbie Duschinsky, Anna Spathis","doi":"10.1089/jayao.2025.0014","DOIUrl":"10.1089/jayao.2025.0014","url":null,"abstract":"","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Support for Adolescent and Young Adult Cancer Survivors: Recommendations on Exercise, Nutrition, and Post-Treatment Care Needs from a Qualitative Study.","authors":"Andrew Murnane, Nicole Kiss, Jeremy Lewin, Steve F Fraser, Anna Ugalde","doi":"10.1089/jayao.2025.0009","DOIUrl":"https://doi.org/10.1089/jayao.2025.0009","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> The aim of this study is to understand how adolescent and young adult cancer survivors (AYA-CS) interact with exercise and nutrition information and programs after treatment, to explore their experiences in accessing these supports, and to identify where they perceive gaps to be in their care. This will include the perspectives of both AYA-CS and the health care professionals who deliver these services. <b><i>Methods:</i></b> A qualitative study using semistructured interviews, undertaken via Zoom. Group 1 consisted of AYA-CS, aged between 15 and 25 years of age at the time of diagnosis who had completed their primary treatment. Group 2 was made up of oncology health care professionals including medical, nursing, and allied health professionals who had a minimum of 2 years' experience working with AYA cancer patients. Thematic analysis was conducted in an inductive manner to develop themes reflecting the needs and experiences of AYA-CS. <b><i>Results:</i></b> Eleven AYA-CS and seven health care professionals, from Australia, treated and working across adult and pediatric settings participated in the interviews. The analysis identified three primary themes \"<i>The ongoing impacts of a cancer diagnosis</i>,\" \"<i>age as a critical construct</i>,\" and \"<i>delivering optimal care</i>.\" <b><i>Conclusions:</i></b> Findings highlight the number of challenges young people face in accessing necessary well-being supports post-treatment, emphasizing the need for individualized exercise and diet interventions. There is a need for health care services to better identify and tailor support for AYA-CS to ensure that their needs are met. Further research is needed to integrate these priorities into clinical practice.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}