Journal of adolescent and young adult oncology最新文献

{"title":"Symptom Burden and Integrative Medicine Consultations Among Adolescents and Young Adults with Cancer: Experience from a Tertiary Care Center.","authors":"Han-Wei V Wu, Diana Dominguez Garcia, Jun J Mao, Nirupa J Raghunathan","doi":"10.1177/21565333261485758","DOIUrl":"10.1177/21565333261485758","url":null,"abstract":"<p><p>Adolescents and young adults (AYAs) with cancer experience substantial symptom burden. Integrative medicine (IM) offers evidence-based symptom management, yet real-world data in AYAs are limited. We retrospectively examined initial IM visits for AYAs (15-39 years) at a tertiary cancer center, abstracting demographics, clinical characteristics, symptoms, and discussions/recommendations. Among 272 AYAs (59.6% female), 42.7% had three concurrent symptoms, most commonly nausea, gastrointestinal issues, and pain. Discussions addressed diet (91.2%), supplements (87.5%), and stress management (77.2%). Nearly half (46.0%) received at least one IM referral, most commonly acupuncture and massage (24.6% each). IM interventions may support symptom management in AYA oncology care.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261485758"},"PeriodicalIF":1.6,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement to Referral for Consultation and Utilization of Reproductive Endocrinology and Infertility Services among Female Childhood Cancer Survivors from a Regional Childhood Cancer Survivorship Clinic.","authors":"Madhumitha Saravanan, Sophia E Kujawski, Jaime L Rotatori, Leah Hirschman, Lyn M Balsamo, Claudia Auerbach, Sonia de Assis, Nagi G Ayad, Gary M Kupfer, Nina S Kadan-Lottick, Rozalyn L Rodwin","doi":"10.1177/21565333261479355","DOIUrl":"https://doi.org/10.1177/21565333261479355","url":null,"abstract":"<p><p>Counseling on infertility risk and fertility preservation (FP) is recommended for childhood cancer survivors (CCS). We describe agreement to and receipt of reproductive endocrinology and infertility (REI) services after counseling during survivorship clinic among female CCS 16-40 years old exposed to gonadotoxic therapy. Of 80 eligible CCS without prior FP or post-therapy REI referrals, 7 (9%) agreed to REI referrals, 1 (1%) attended REI consults, and 0 underwent FP. Survivors who agreed and did not agree to REI referrals had similar characteristics and infertility risk. Research to better understand patient-level barriers post-therapy and increase FP engagement is warranted.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261479355"},"PeriodicalIF":1.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delivery of Guideline Concordant Supportive Care for AYAs with Cancer in a Statewide Population-Based Cohort.","authors":"Jacob N Stein, Christopher D Baggett, Emily R Haines, Nicole Knape, Jennifer L Lund, Hannah C Winslow, KyungSu Kim, Jordan Lodato Hunt, Alison Manikowski, Catherine Habashy, Andrew B Smitherman, Katherine E Reeder-Hayes","doi":"10.1177/21565333261481958","DOIUrl":"https://doi.org/10.1177/21565333261481958","url":null,"abstract":"<p><strong>Purpose: </strong>In the past two decades, there has been a growing recognition of the unique needs of adolescent and young adult (AYA) cancer patients. Alongside this recognition is the emergence of guidelines for high-quality AYA cancer care. Despite such tailored guidelines, preliminary studies suggest a gap between recommended versus received care among AYAs. We sought to examine patterns in receipt of guideline-concordant care among this population using a state-wide claims database.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using the Cancer Information and Population Health Resource, a linkage of North Carolina claims data and cancer registry data, to examine receipt of guideline-concordant care among patients ages 13-39 years with seven of the most common AYA cancer types. We explored differences in receipt of care by clinical and sociodemographic factors and conducted multivariate logistic regression incorporating both patient and provider-level variables to evaluate care delivery.</p><p><strong>Results: </strong>Across these measures of guideline-concordant care-fertility preservation (13%), psychosocial/mental health care (37%), and palliative care (45%), documented receipt was observed in less than half of the cohort. Differences in receipt of guideline-concordant care emerged across sociodemographic and clinical characteristics, including higher frequency of fertility preservation for adolescents (adjusted Risk Ratio [aRR] 1.76), lower rates for rural patients (aRR 0.40), and lower rates of mental health care for Black (aRR 0.61) and Hispanic (aRR 0.63) AYAs.</p><p><strong>Conclusion: </strong>In our cohort, guideline-concordant care was delivered inconsistently across a statewide AYA cancer population. These findings reaffirm the need for continued efforts to integrate fertility preservation, mental health, and palliative care into care delivery for AYAs. Further system- and provider-level efforts are needed to ensure guideline-concordant care is delivered equitably across clinical and sociodemographic groups.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261481958"},"PeriodicalIF":1.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Markers of Early Skeletal Muscle Loss in Adolescent and Young Adult Cancer Patients Treated with Anthracyclines.","authors":"Savannah V Rauschendorfer, Amanda Brandt, Behrang Amini, J Andrew Livingston, Michael E Roth, Eugenie S Kleinerman, Michelle A T Hildebrandt","doi":"10.1177/21565333261481969","DOIUrl":"https://doi.org/10.1177/21565333261481969","url":null,"abstract":"<p><strong>Purpose: </strong>Skeletal muscle (SM) loss occurs during early anthracycline treatment in adolescent and young adult (AYA) cancer patients. Identifying those at greatest risk is critical for prevention. This study aimed to determine if genetic variants previously associated with SM loss in the general population are also associated with SM loss in AYA cancer patients receiving anthracycline chemotherapy.</p><p><strong>Methods: </strong>SM change was quantified via computed tomography for 138 AYA cancer patients. The genome-wide association studies (GWAS) catalog was queried to identify candidate variants associated with SM index (SMI) or sarcopenia. Of the 18 GWAS-implicated variants, genotyping data were available in the study population for nine. Multivariable logistic regression was performed for each variant and risk of SM loss at the end of treatment and 1-year follow-up with adjustment for anthracycline dose, radiation exposure, diagnosis, sex, age, and follow-up time.</p><p><strong>Results: </strong>The T allele of rs97384 (chr11:61624181) located in the fatty acid desaturase 2 (<i>FADS2</i>) gene was associated with risk of SM loss with a significant association for SM density (SMD) at follow-up (odds ratio: 2.37, 95% confidence interval: 1.27-4.45, <i>p</i> = 0.007). This variant was also borderline significant (<i>p</i> < 0.10) for SMD at baseline and SMI at follow-up. Integration of other variants within the <i>FADS2</i> region identified several loci with more significant associations with SM loss in our patient population than that conferred by rs97384.</p><p><strong>Conclusion: </strong>Genetic variants previously associated with SM loss in the general population were significantly associated with SMD reduction post-anthracycline treatment in AYAs. Thus, providing the possibility of SM loss risk assessment in this high-risk patient population.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261481969"},"PeriodicalIF":1.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seen, Heard, and Still Missing: Understanding Clinical Trial Nonparticipation Among Women of Color.","authors":"Jasmine Dionne Souers, Marissa Thomas, Juliette Faughnan, Mary Fox, Nishtha Gupta, Gail Betz, Adishree Nayak, Nathaniel Laban, Christabel K Cheung","doi":"10.1177/21565333261479352","DOIUrl":"https://doi.org/10.1177/21565333261479352","url":null,"abstract":"<p><strong>Purpose: </strong>To examine structural, informational, and cultural barriers to clinical trial participation among women of color (WOC), with emphasis on adolescents and young adults (AYAs), through a community-partnered study to illuminate persistent challenges and generate actionable strategies through community-driven research.</p><p><strong>Methods: </strong>In partnership with <i>For the Breast of Us</i>, a national advocacy organization for WOC affected by breast cancer, we conducted a sequential exploratory mixed-methods study. In-depth interviews (<i>n</i> = 59) informed a national online survey (<i>n</i> = 421) assessing trial perceptions, knowledge, and participation among WOC across the United States, both with and without a breast cancer diagnosis, the majority of whom were AYAs.</p><p><strong>Results: </strong>Five themes emerged distrust and historical harms; logistical and structural barriers; cultural relevance and representation; fear and silence; and access to health care and information. Quantitatively, WOC were less likely than White women to have discussed trials with a provider (36% vs. 58%, <i>p</i> < 0.05), to know how to enroll (64% vs. 41%, <i>p</i> < 0.01), and to perceive trials as \"not for people like me\" (79% vs. 47%, <i>p</i> < 0.01). Age-stratified analyses further showed that women ages 19-30 reported lower clinical trial knowledge and greater informational, trust-related, and practical barriers than older participants.</p><p><strong>Conclusion: </strong>Barriers to trial participation are structurally embedded and racially patterned, with age-stratified findings suggesting distinct informational, trust-related, and practical barriers among younger women. Transforming who clinical trials are for begins by transforming how they are built.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261479352"},"PeriodicalIF":1.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet Needs of Adolescent and Young Adult Cancer Survivors Treated in West Virginia: A Qualitative Analysis of Open-Ended Survey Responses.","authors":"Konstantinos Sdrimas, Bei Jiang, Laurel Lyckholm, Nicole L Stout","doi":"10.1177/21565333261481997","DOIUrl":"https://doi.org/10.1177/21565333261481997","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize unmet supportive care needs among adolescent and young adult (AYA) cancer survivors in rural West Virginia.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey of individuals diagnosed with cancer at ages 15-39 and treated within the West Virginia University Health System from 2012-2023. The questionnaire included the Adolescent and Young Adult Health Outcomes and Patient Experience (AYA HOPE) Survey, the Veterans RAND 12-Item Health Survey (VR-12), and optional open-ended questions. This report focuses on the open-ended responses, which three team members independently coded using conventional qualitative content analysis before reaching consensus on themes and representative quotations. Closed-ended instrument data were outside the scope of this analysis.</p><p><strong>Results: </strong>Among 1,621 deliverable invitations, 79 surveys were completed (4.9%); 22 respondents provided open-ended text (27.8% of completers; 1.4% of deliverable invitations). Five themes were identified: information and education gaps; social isolation; treatment and pain-management concerns; financial and logistical burdens; and survivorship and re-entry challenges.</p><p><strong>Conclusion: </strong>Participants described needs that largely mirror those reported across AYA populations, while transportation, service availability, and geographic dispersion may shape how support is delivered in rural West Virginia. These findings may inform the development and evaluation of age-appropriate survivorship, navigation, mental health, fertility, and peer-support services across rural care networks.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261481997"},"PeriodicalIF":1.6,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Corrigendum to:</i> Assessing Palliative Care Needs Among Adolescent and Young Adult Patients with Cancer and Their Caregivers in South Korea.","authors":"","doi":"10.1177/21565333261478505","DOIUrl":"10.1177/21565333261478505","url":null,"abstract":"","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261478505"},"PeriodicalIF":1.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Vulnerability and the Relationship Between Maternal Caregiver Condition Management Ability and Transition Readiness in Young Adult Survivors of Childhood Brain Tumors.","authors":"Ashley Anil, Shannon N Hammer, Wendy L Hobbie, Brian P Daly, Janet A Deatrick, Lamia P Barakat","doi":"10.1177/21565333261479353","DOIUrl":"https://doi.org/10.1177/21565333261479353","url":null,"abstract":"<p><strong>Purpose: </strong>To utilize the social-ecological model of adolescent and young adult readiness to transition to understand the interplay of social determinants of health with condition management ability (CMA) of caregivers of young adult survivors of childhood brain tumors (YAS).</p><p><strong>Methods: </strong>Maternal caregivers (<i>N</i> = 53) of 18- to 29-year-old YAS ≥2 years off-treatment living at home were screened into a problem-solving intervention randomized trial based on their risk of poorer CMA. They completed the Transition Readiness Assessment Questionnaire (TRAQ) and rated YAS cognitive late effect severity prior to randomization. Medical experts scored cognitive medical sequelae and treatment intensity. Social vulnerability was rated using the CDC/ATSDR social vulnerability index.</p><p><strong>Results: </strong>CMA was not related to transition readiness when accounting for cognitive late effects. Cognitive late effects were associated with transition readiness (<i>p</i> < 0.01). For families with less social vulnerability, higher cognitive late effects were associated with poorer CMA, which was in turn related to lower managing daily activities and tracking health issues subscales of transition readiness. There were no other significant relationships.</p><p><strong>Conclusion: </strong>For families with more resources, CMA may explain the relationship between cognitive late effects and transition readiness, although findings were inconsistent by the TRAQ subscale. Additional investigation of social vulnerability in CMA and transition readiness is needed. Findings highlight the saliency of mitigating cognitive late effects resulting from childhood brain tumors and their treatment. There is a significant need for ongoing resources to support both ongoing condition management and transition readiness in the period of young adulthood for YAS.</p>","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"21565333261479353"},"PeriodicalIF":1.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations for Psychosocial Care in Adolescent and Young Adult Oncology.","authors":"Marie Barnett, Tori Hinton, Sarah Daniels, Cristina Pozo-Kaderman, Heather Haluska, Mandy Little, Lori Wiener","doi":"10.1177/21565333251393030","DOIUrl":"10.1177/21565333251393030","url":null,"abstract":"","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"256-259"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145389781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Research for Adolescents and Young Adults Cancer: A Position Statement.","authors":"Anao Zhang, Stephanie Dixon, Victoria W Willard, Archie Bleyer","doi":"10.1177/21565333251392237","DOIUrl":"10.1177/21565333251392237","url":null,"abstract":"","PeriodicalId":14769,"journal":{"name":"Journal of adolescent and young adult oncology","volume":" ","pages":"239-241"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145367860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}