Journal Der Deutschen Dermatologischen Gesellschaft最新文献

{"title":"Successful treatment of subacute cutaneous lupus erythematosus with the TYK-2 inhibitor deucravacitinib in a patient with concomitant psoriasis vulgaris.","authors":"Katharina Assaf, Selina Patt, Valentin Sebastian Schäfer, Jörg Wenzel, Natalija Novak, Dagmar Wilsmann-Theis","doi":"10.1111/ddg.15705","DOIUrl":"https://doi.org/10.1111/ddg.15705","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of squamous cell carcinoma on hidradenitis suppurativa lesions - a case series.","authors":"Nessr Abu Rached, Riina Käpynen, Yannik Haven, Lennart Ocker, Carolin Frost, Eggert Stockfleth, Falk G Bechara","doi":"10.1111/ddg.15708","DOIUrl":"https://doi.org/10.1111/ddg.15708","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial hyperpigmentation caused by pigmented demodicosis","authors":"Ephsona Shencoru, Annika Vogt, Kamran Ghoreschi","doi":"10.1111/ddg.15682","DOIUrl":"10.1111/ddg.15682","url":null,"abstract":"<p>Dear Editors,</p><p>We present a case of facial hyperpigmentation caused by demodicosis in an adolescent. Demodicosis is a skin condition due to the overgrowth of <i>Demodex</i> mites, primarily <i>Demodex folliculorum</i> and <i>Demodex brevis</i>. These ectoparasites are obligate inhabitants of human skin, particularly in the sebaceous glands and hair follicles, but can become relevant under certain conditions, such as immunosuppression, pityriasis folliculorum, or chronic skin disorders like rosacea.<span><sup>1</sup></span> Recently, it has also been described as a cause of facial hyperpigmentation, leading to the term “pigmented demodicosis”. We report a case of facial hyperpigmentation caused by <i>Demodex</i> mites and successful treatment.</p><p>A 16-year-old male patient presented with progressing asymptomatic hyperpigmentation on his face. His medical history was devoid of any significant findings. Previous treatments included topical retinoid (0,1% adapalene) and hydroquinone 5% without any noticeable improvement. Two months before the consultation at our clinic, the patient initiated treatment with oral isotretinoin at 10 mg per day.</p><p>Dermatological examination revealed dusky brown-grey macules on his cheeks, forehead, and temples, developing into larger patches over the past 2 years (Figure 1a). A previous biopsy described lymphocytic infiltration and melanophages in favor of postinflammatory hyperpigmentation or lichenoid dermatitis. Therefore, we repeated the biopsy to differentiate between our differential diagnoses, including lichen planus pigmentosus, erythema dyschromicum perstans, and rosacea. Histopathological examination presented Demodex mites in dilated hair follicles, melanophages and perivascular lymphocytic infiltration (Figure 1b).</p><p>Taking histopathology findings, such as a combination of mites, interface reaction of the hair follicle epithelium into account with the clinical presentation we diagnosed pigmented demodicosis. In addition to systemic retinoid treatment, we initiated ivermectin 1% cream once daily. During the follow-up visit, a significant improvement in overall hyperpigmentation and skin texture was observed after just 3 months of treatment (Figure 2).</p><p><i>Demodex</i> mites are commensal ectoparasites. Only <i>Demodex brevis</i> and <i>Demodex folliculorum</i> have been identified on human skin.<span><sup>2</sup></span> The overproliferation of <i>Demodex</i> mites can trigger inflammatory responses and play a role in skin conditions such as rosacea. Treatment generally includes topical anti-demodectic agents, such as ivermectin, aimed at reducing mite populations and alleviating symptoms. <i>Demodex</i>-induced facial hyperpigmentation is still an underdiagnosed cause of facial hyperpigmentation. Feuerstein et al. published a case series and proposed the term “pigmented demodicosis”.<span><sup>3</sup></span> To diagnose demodicosis, the literature has also described additional dermoscop","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 5","pages":"658-659"},"PeriodicalIF":5.5,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15682","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatological indicator condition guided testing for HIV: experience of a reference dermatology center","authors":"Jorinta Jokubaitė, Eglė Janušonytė, Tadas Raudonis","doi":"10.1111/ddg.15680","DOIUrl":"10.1111/ddg.15680","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 5","pages":"656-657"},"PeriodicalIF":5.5,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract","authors":"","doi":"10.1111/ddg.15735_g","DOIUrl":"https://doi.org/10.1111/ddg.15735_g","url":null,"abstract":"<p>Rupesh Paudel<sup>1,2*</sup>, Lena F Sorger<sup>1*</sup>, Anita Hufnagel<sup>1</sup>, Mira Pasemann<sup>1</sup>, Tamsanqa Hove<sup>1,3</sup>, André Marquardt<sup>1,4</sup>, Susanne Kneitz<sup>5</sup>, Andreas Schlosser<sup>6</sup>, Caroline Kisker<sup>3</sup>, Jochen Kuper<sup>3#</sup>, Svenja Meierjohann<sup>1,4#</sup></p><p><sup>1</sup>Institute of Pathology, University of Würzburg, 97080 Würzburg, Germany</p><p><sup>2</sup>Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany.</p><p><sup>3</sup>Rudolf Virchow Center for Integrative and Translational Bioimaging, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany</p><p><sup>4</sup>Comprehensive Cancer Center Mainfranken, University of Würzburg, 97080 Würzburg, Germany</p><p><sup>5</sup>Department of Biochemistry and Cell Biology, University of Würzburg, 97074 Würzburg, Germany</p><p><sup>6</sup>Rudolf Virchow Center for Integrative and Translational Bioimaging, Mass Spectrometry Division, University of Würzburg, 97080 Würzburg, Germany</p><p><sup>#</sup>corresponding authors:</p><p>J Kuper (<span>[email protected]</span>)</p><p>S Meierjohann (<span>[email protected]</span>)</p><p>*These authors contributed equally to this work</p><p><b>Abstract</b></p><p>Germline mutations in the DNA repair helicase XPD cause the diseases xeroderma pigmentosum (XP), trichothiodystrophy (TTD) and Cockayne syndrome. XP patients bear an increased risk of developing skin cancer including melanoma, even at young age. This is not observed for TTD patients despite DNA repair defects. To examine whether TTD cells harbor features counteracting tumorigenesis, we developed a TTD melanoma cell model containing the XPD variant R722W. Intriguingly, TTD melanoma cells exhibited reduced pro-tumorigenic features and an increased signature of the melanocyte lineage differentiation factor MITF, which went along with a strong basal upregulation of REDD2, an inhibitor of the mTOR/S6K/4EBP1 dependent protein translation machinery. REDD2 levels were partially driven by MITF, increased under UV exposure, and contributed to the reduced melanoma proliferation. To investigate whether similar processes are affected in melanocytes - the progenitor cell type of melanoma - we developed a TTD melanocyte model. Again, the MITF gene signature was increased, this time without affecting REDD2 expression. However, protein translation analyses revealed reduced ribosomal protein synthesis particularly in R722W melanocytes after UV stress, indicating a compromised protein translation machinery. Impaired protein translation was also demonstrated for the TTD XPD variant A725P, but not for the XPD variant D234N that causes XP. Concludingly, although effectors of R722W partially differ between melanoma cells and melanocytes, they result in translation inhibition and therefore reduced fitness, particularly under UV exposure. This may limit the probability of UV-driven","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 S2","pages":"3-20"},"PeriodicalIF":5.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15735_g","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autorenverzeichnis","authors":"","doi":"10.1111/ddg.15794","DOIUrl":"https://doi.org/10.1111/ddg.15794","url":null,"abstract":"<p>Abiona, A. 5, 14</p><p>Anazodo, A. 9</p><p>Apelt, K. 19</p><p>Arseni, L. 4</p><p>Baghoomian, W. 13</p><p>Balgos, K. 5</p><p>Berneburg, M. 10, 15</p><p>Bhattacharjee, R. 14</p><p>Bini, L. 4</p><p>Björn, S. 10</p><p>Bodi, I. 14</p><p>Boeckmann, L. 8</p><p>Bogner, C. 10</p><p>Bohr, V. A. 17</p><p>Boissière, T. 19</p><p>Botta, E. 3, 9, 17</p><p>Branca, G. 4, 17</p><p>Brevi, F. 9</p><p>Cepeda-Valdes, R. 13</p><p>Cimmaruta, C. 10</p><p>Compe, E. 4</p><p>Cramer, P. 19</p><p>Craythorne, E. 14</p><p>D. Schärer, O. D. 19</p><p>D'Souza, A. 19</p><p>Dangeleit, S. 14</p><p>de Lint, K. 19</p><p>Dell'Ambra, E. 3</p><p>DiDonato, N. 8</p><p>DiGiovanna, J. J. 13, 18</p><p>Diletta, G. 6</p><p>Elena, P. 6</p><p>Emma, V. 6</p><p>Emmert, S. 8</p><p>Erden, N. 15</p><p>Farnung, L. 13</p><p>Fassihi, H. 5, 12, 14, 15</p><p>Ferri, D. 4, 17</p><p>Ficht, P.-K. 8</p><p>Ficht, P. 8</p><p>Filippi, S. 7</p><p>Fleszar, Z. 14</p><p>Gandolfi, E. 4, 17</p><p>Garcia-Moreno, H. 14</p><p>Garrood, I. 5, 14</p><p>Giunti, P. 5, 14</p><p>Gronwald, W. 10</p><p>Guida, G. 17</p><p>Guzzon, D. 7</p><p>Hasanhodzic, M. 8</p><p>Hempel, M. 8</p><p>Henshaw, T. 5, 14</p><p>Herlihy, A. E. 19</p><p>Hove, T. 3</p><p>Hufnagel, A. 3</p><p>Iben, S. 9</p><p>Kamenisch, Y. 10</p><p>Kashyap, K. 19</p><p>Keogh, R. 5</p><p>Khan, S. G. 13, 18</p><p>Kim, H.-S. 19</p><p>Kirdök, I. 19</p><p>Kisker, C. 3</p><p>Kneitz, S. 3</p><p>Kokic, G. 19</p><p>Kraemer, K. H. 13, 18</p><p>Krutmann, J. 14</p><p>Kümmecke, M. 13</p><p>Kuper, J. 3</p><p>Kuschal, C. 13</p><p>Kuzmich, O. 8</p><p>Lajus, T. B. P. 12</p><p>Landi, C. 4</p><p>Langan, S. M. 5</p><p>Langbehn, D. R. 14</p><p>Lans, H. 17</p><p>Lanzafame, M. 3, 4, 17</p><p>Laugel, V. 10</p><p>Lee, M. P. 13</p><p>Lehmann, A. R. 5, 14</p><p>Lehmann, A. 9, 15</p><p>Lemken, A. 8</p><p>Ljungman, M. 19</p><p>Lombardi, A. 3</p><p>Luca, P.-D.-S. 6</p><p>Luijsterburg, M. S. 19</p><p>Maga, G. 4</p><p>Majora, M. 14</p><p>Manes, M. A. 14</p><p>Marquardt, A. 3</p><p>Marteijn, J. A. 17</p><p>Martin, L. 9, 10</p><p>Martin, L. K. 9</p><p>Maver, A. 8</p><p>McLoone, J. 9</p><p>Meierjohann, S. 3</p><p>Menck, C. F. M. 12</p><p>Mevissen, T. E. T. 13</p><p>Mitter, R. 19</p><p>Mohammed, S. 5, 14</p><p>Moreno, N. N. 19</p><p>Moriwaki, S. 16</p><p>Morley, A. M. S. 5, 14</p><p>Naik, H. 14</p><p>Nardo, T. 3, 17</p><p>Nikolaev, S. 12, 19</p><p>Nishigori, C. 12, 16</p><p>Orioli, D. 3. 4. 9, 17</p><p>Paccosi, E. 7</p><p>Palfrey, J. 5</p><p>Panzer, R. 8</p><p>Paolini, R. 10</p><p>Paolino, A. 5</p><p>Park, J. 19</p><p>Pasemann, M. 3</p><p>Paudel, R. 3</p><p>Peverali, F. A. 4</p><p>Porrmann, J. 8</p><p>Primal, D. L. 6</p><p>Proietti De Santis, L. 7</p><p>Rajabi, F. 12</p><p>Ricchetti, M. 10</p><p>Riva, V. 4</p><p>Rodríguez-Martínez, M. 19</p><p>Rossi, A. 14</p><p>Sabatella, M. 17</p><p>Salas-Alanis, J. 13</p><p>Sarasin, A. 12, 19</p><p>Sarkany, R. 18</p><p>Sarkany, R. P. E. 14</p><p>Schlosser, A. 3</p><p>Schmid, E. W. 13</p><p>Scholz, T. 8</p><p>Schumacher, B. 15</p><p>Silvia, F. 6</p><p>Sorger, L. 3</p><p>So","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 S2","pages":"21-22"},"PeriodicalIF":5.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15794","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of argyria as consequence of alternative medical treatment.","authors":"Murat Cavdar, Damian Kostner, Mathias Drach, Veronique Touzeau-Römer, Katharina Grabmeier-Pfistershammer, Johanna Strobl","doi":"10.1111/ddg.15707","DOIUrl":"https://doi.org/10.1111/ddg.15707","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical ivermectin 10 mg/g cream alone or in combination with oral doxycycline for patients with perioral dermatitis (POD): A retrospective case series.","authors":"Martin Schaller, Daniela Lenders, Gabi Handgretinger, Andrea Gawaz","doi":"10.1111/ddg.15691","DOIUrl":"https://doi.org/10.1111/ddg.15691","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rosacea in childhood and adolescence: A review.","authors":"Sören Korsing, Karola Stieler, Uwe Pleyer, Ulrike Blume-Peytavi, Annika Vogt","doi":"10.1111/ddg.15693","DOIUrl":"https://doi.org/10.1111/ddg.15693","url":null,"abstract":"<p><p>Despite presenting with similar symptoms, triggers, and progression patterns as adults, rosacea in children and adolescents is frequently overlooked as a primary differential diagnosis. However, initial manifestations of classic clinical types can be observed from infancy onwards. The frequent association of childhood rosacea with ophthalmologic manifestations is of particular importance in addition to the knowledge of special subtypes such as idiopathic aseptic facial granuloma. Therapeutic options of pediatric rosacea partly overlap with those of common differential diagnoses such as acne vulgaris or perioral dermatitis. However, both the disease itself and its manifestation in this age group entail challenges in the selection of active ingredients and the development of therapeutic concepts. In addition, advice on triggering and aggravation factors is required in order to provide optimal long-term support for those affected.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated limb perfusion as a limb-saving therapy for locally advanced squamous cell carcinoma","authors":"Maria Cristina Fialho,&nbsp;Ana Ferreirinha,&nbsp;Joana Bártolo,&nbsp;Victor Farricha","doi":"10.1111/ddg.15677","DOIUrl":"10.1111/ddg.15677","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 5","pages":"654-655"},"PeriodicalIF":5.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}