Journal Der Deutschen Dermatologischen Gesellschaft最新文献

{"title":"Skin lesions after hematopoietic stem cell transplantation: Graft-versus-host disease versus true dermatomyositis","authors":"Alba Calleja Algarra, Borja González Rodriguez, Jon Fulgencio Barbarin, Fátima Tous Romero, Virginia Velasco Tamariz, Lorena Calderón Lozano, Pablo Luis Ortiz-Romero, Carlos Zarco Olivo","doi":"10.1111/ddg.15681","DOIUrl":"10.1111/ddg.15681","url":null,"abstract":"<p>Dear Editors,</p><p>Chronic graft-versus-host disease (cGVHD) is an alloimmune and autoimmune complication of hematopoietic stem cell transplantation (HSCT). It is well documented that cGVHD may develop in some cases after allo-HSCT, representing a variety of symptoms closely similar to those in autoimmune diseases. Sometimes true autoimmune diseases can also develop. The occurrence of autoimmune diseases after allogeneic HSCT is infrequent and difficult to interpret due to the reconstitution of the immune system and the multifactorial origin of most of these diseases.<span><sup>1, 2</sup></span></p><p>We present a case of a patient who developed a cGVHD with identical cutaneous manifestations to dermatomyositis. A 45-year-old-woman with a previous history of acute myeloid leukemia was treated with an allogenic HSCT. She developed an acute graft-versus-host disease with cutaneous involvement with good response to steroids and sirolimus.</p><p>Six months later cGVHD intestinal symptoms began. In addition, scaling plaques on the scalp and adjacent to the back of metacarpophalangeal and interphalangeal joints appeared (Figure 1). She had similar scaly plaques on the eyelids and a slight Gottron sign was noticeable on the elbows. Capillaroscopy of the nail fold showed a normal pattern.</p><p>A cutaneous biopsy was performed showing epidermal hyperplasia, hypergranulosis, and parakeratosis. Superficial interface dermatitis with vacuolar changes in the basilar layer was noted with a lymphocytic infiltrate in a band pattersn distribution (Figure 2). Apoptotic keratinocytes were observed within the epidermis (Figure 3).</p><p>This supported the diagnosis of dermatomyositis-like cGVHD. Muscle symptoms were not reported by the patient. CK and aldolase levels were normal. Antinuclear antibody testing was negative with decreased levels of C3. Myositis antibody-specific blot was negative.</p><p>One year after transplantation, the patient died of respiratory sepsis with a torpid course.</p><p>Dermatomyositis-like presentations after HSCT are very rarely reported. It can appear between 4 and 52 months after HCST. Skin manifestations may be identical to dermatomyositis. Cases with muscle involvement confirmed by muscle biopsy and severe cases with progressive interstitial lung disease associated with MDA5 antibodies have also been described.<span><sup>3</sup></span></p><p>cGVHD histological findings are not specific and diagnosis requires clinicopathological correlation. Also, common histological features can be found in skin biopsies of dermatomyositis and cGVHD. Most representative histopathological findings in cutaneous dermatomyositis include interface dermatitis, mucin deposits, and perivascular inflammation. In contrast, a lichenoid infiltration pattern and apoptotic keratinocytes are more common in cGVHD.</p><p>The distinction between dermatomyositis-like cGVHD and a true dermatomyositis is complex. The isolated finding of complete chimerism of donor l","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 4","pages":"513-515"},"PeriodicalIF":5.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15681","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete response of a metastatic cutaneous apocrine carcinoma under oral S-1 monotherapy","authors":"Shoichiro Ishizuki, Yoshiyuki Nakamura, Ko Matsuoka, Yasuhiro Fujisawa, Toshifumi Nomura","doi":"10.1111/ddg.15652","DOIUrl":"10.1111/ddg.15652","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 4","pages":"524-526"},"PeriodicalIF":5.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc deficiency-associated dermatitis in a prematurely born infant","authors":"Jennifer Grötsch, Michael Sticherling","doi":"10.1111/ddg.15637","DOIUrl":"10.1111/ddg.15637","url":null,"abstract":"<p>A 6-month-old male infant presented with his mother to our dermatology outpatient clinic with patchy, scaly, and crusted erythema on his cheeks and neck, accompanied by oral erosions. At the age of 3.5 months, the infant had developed first skin lesions around the earlobes followed by general weakness due to restricted oral intake caused by mucosal lesions at 5.5 months. Using local antiseptics and antimycotics as well as systemic antibiotics, no sufficient and persistent improvement of the symptoms could be achieved. The presentation to our hospital was due to a progressive deterioration of his dermatological findings as well as his general condition.</p><p>Following premature amnion rupture in the 30th week of pregnancy, the boy was born naturally 7 weeks before the due date (33rd week of pregnancy) after an otherwise uneventful pregnancy and treated prophylactically with ampicillin and gentamicin for 7 days. Diarrhea, other previous diseases, or allergies were absent, and no permanent medications had been administered. Both parents were healthy with atopic dermatitis and rhinoconjunctivitis allergica in the uncle. There were no pets in the household nor any history of travel abroad. The mother had been on a vegetarian diet before pregnancy, but reintroduced meat and a balanced diet upon the onset of her pregnancy. At presentation, the mother was still fully breastfeeding the boy.</p><p>Clinically, lightning figure-like, sharply demarcated and partially confluent erythema on both cheeks and the neck with marginal, mid-lamellar scaling and whitish-yellowish crusting (Figure 1a) were found. The upper lip and forehead were spared, whereas small, spotted erosions on the hard palate were observed enorally (Figure 1b). No other abnormal physical findings were noted including pre-auricular, retroauricular or cervical lymph nodes. The infant's earlier development appeared regular.</p><p>Neither bacterial nor mycological pathogens could be detected in skin swabs. Clinical chemistry laboratory examination showed a markedly decreased serum zinc level of 0.11 mg/l (reference range: 0.70–1.10 mg/l). All other evaluated laboratory parameters, including electrolytes, liver and kidney values, C-reactive protein (CRP), and differential blood count, were within normal ranges.</p><p>As part of further investigations, at 0.77 mg/l the mother's serum zinc level was found to be within normal limits, similar to the zinc level in the mother's milk at different time points during lactation (1st time point of mother's milk zinc level measurement at infant's age of 5.5 months: 354 µg/l, 2nd time point of mother's milk zinc level measurement at infant's age of 12 months: 288 µg/l; normal range: 170–3,020 µg/l).</p><p>Initially, an improvement of the skin findings could be achieved by local therapy starting with fusidic acid once a day, intensified after 1 week with the overlapping use of a class II steroid (prednicarbate) for 2 weeks in a tapered dosage (2 x daily for ","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 4","pages":"509-512"},"PeriodicalIF":5.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tattoo-induced hypertrophic discoid lupus erythematosus in a patient with vitiligo","authors":"Yuan-Yu Hong, I-Jung Hsieh, Sui-Qing Cai","doi":"10.1111/ddg.15670","DOIUrl":"10.1111/ddg.15670","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 4","pages":"516-518"},"PeriodicalIF":5.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erwerbstätigkeit, Arbeitsfähigkeit und Krankenstand bei Patienten mit Melanom im ersten Jahr nach der Diagnose","authors":"Susanne Dugas-Breit, Martin Dugas, Hans-Joachim Schulze","doi":"10.1111/ddg.15560_g","DOIUrl":"https://doi.org/10.1111/ddg.15560_g","url":null,"abstract":"<p>Das maligne Melanom der Haut galt noch vor wenigen Jahrzehnten als seltener Tumor, belegte jedoch im Jahr 2015 in Deutschland den fünften Platz der häufigsten soliden Tumorentitäten sowohl bei Männern als auch bei Frauen.<span><sup>1</sup></span> Das Melanom als Hauttumor mit der höchsten Metastasierungsrate ist für mehr als 90% aller Todesfälle durch Hauttumoren verantwortlich. Eine Analyse der Inzidenz in Australien, Neuseeland, Norwegen, Schweden, Großbritannien sowie der weißen Bevölkerung der USA von 1982 bis 2011 ergab einen deutlichen Anstieg von etwa 3% jährlich.<span><sup>2</sup></span> In Deutschland stieg die altersstandardisierte Inzidenzrate im Zeitraum von 1970 bis 2016 von drei auf 21 Fälle pro 100 000 Einwohner und Jahr. Das mediane Erkrankungsalter lag 2020 für Frauen bei 63 Jahren und für Männer bei 69 Jahren.<span><sup>1</sup></span> Die Altersverteilung zeigt zwei Gipfel: Junge Erwachsene bis etwa 30 Jahre sowie ältere Personen über 50 Jahre erkranken besonders häufig am Melanom. Bei Frauen zwischen 20 und 30 Jahren ist das Melanom die häufigste Krebsart in Deutschland, noch häufiger als Brustkrebs.<span><sup>3</sup></span> Berufstätige sind daher besonders häufig von dieser Erkrankung betroffen.<span><sup>1, 4</sup></span></p><p>Im Jahr 2015 führte die Diagnose eines Melanoms bei 335 von 100 000 aktiv Versicherten in der gesetzlichen Rentenversicherung zur vorzeitigen Verrentung, davon waren 107 Personen unter 50 Jahre alt.<span><sup>5</sup></span> Daher stellt sich die Frage, ob die Neudiagnose eines Melanoms Auswirkungen auf die Arbeitsfähigkeit der Patienten hat. Bei einer umfangreichen Literaturrecherche mit den Suchbegriffen „workability“, „employment“, „occupation“ oder „sick leave“ konnten wir nur relativ wenige, schlecht vergleichbare Studien zu diesem Thema finden. Eine US-Studie aus dem Jahr 2012 ergab, dass jährlich 3,31 Millionen US-Arbeitnehmer an Krebs erkrankten, was zu etwa 33,4 Millionen Arbeitsunfähigkeitstagen führte. Das Melanom war hier im Vergleich zu anderen Krebsarten mit einer höheren Krankheitslast verbunden.<span><sup>6</sup></span></p><p>Entstellende oder funktionseinschränkende Operationen können zu körperlichen und psychischen Belastungen führen, ebenso wie Nebenwirkungen von Medikamenten. Die medizinische Rehabilitation von Patienten mit Melanom zielt darauf ab, körperliche, geistige, soziale und berufliche Beeinträchtigungen zu verhindern oder zu verringern und die soziale Teilhabe aufrechtzuerhalten. Weitere Ziele sind die Verbesserung der Lebensqualität und eine möglichst dauerhafte Wiedereingliederung in das Arbeitsleben,<span><sup>7</sup></span> also die Förderung der Arbeitsfähigkeit. Daher sind für komplexe onkologische Symptome nur interdisziplinäre Behandlungsstrategien geeignet. Die aktuelle Leitlinie der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften zum Melanom<span><sup>7</sup></span> empfiehlt, Rehabilitationsmaßnahmen bereits im Rahmen der Primärver","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 2","pages":"151-160"},"PeriodicalIF":5.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15560_g","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Omics Analysen bei Plaque-Psoriasis – Neue Wege gehen","authors":"Thomas Graier","doi":"10.1111/ddg.15650_g","DOIUrl":"https://doi.org/10.1111/ddg.15650_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 2","pages":"279-280"},"PeriodicalIF":5.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drei neue Ehrenmitglieder in der Fachgesellschaft – Die DDG ehrt Prof. Christine Bodemer, Prof. Luca Borradori und Prof. Peter Fritsch","authors":"Dagmar Arnold","doi":"10.1111/ddg.15690_g","DOIUrl":"https://doi.org/10.1111/ddg.15690_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 2","pages":"285-286"},"PeriodicalIF":5.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indikation zur Systemtherapie bei Psoriasis: Kommentierte Checkliste für die Praxis","authors":"Ralph von Kiedrowski,&nbsp;Ulrich Mrowietz,&nbsp;Matthias Augustin","doi":"10.1111/ddg.15613_g","DOIUrl":"https://doi.org/10.1111/ddg.15613_g","url":null,"abstract":"<p>Die Systemtherapie der mittelschweren bis schweren Psoriasis hat sich zu einem der wichtigsten Pfeiler in der Versorgung entwickelt und weist eine wachsende Vielfalt auf.<span>^1-3</span> Für eine qualitätsgesicherte dermatologische Arzneimittelversorgung sind Standards in der Indikationsstellung von hoher Wichtigkeit. Dies gilt insbesondere für den Einsatz therapeutischer Innovationen. Eine essenzielle Anforderung an entsprechende Standards ist deren hohe Verständlichkeit, Eindeutigkeit, rechtliche Sicherheit und praktische Handhabbarkeit. Die Praktikabilität ist von besonderer Bedeutung. Für die Indikationen atopische Dermatitis, Vitiligo und chronische Prurigo wurden entsprechende Checklisten bereits entwickelt und in den Leitliniengruppen konsentiert.<span>^4-6</span></p><p>Von Mitgliedern der S3-Leitliniengruppe zur Psoriasis wurde jetzt auch eine Checkliste zur Indikationsstellung der Systemtherapie bei Psoriasis entwickelt (Abbildung 1), die sich inhaltlich an die geltende S3-Leitlinie anlehnt.</p><p>Mit der vorliegenden Checkliste wurde eine Lücke in der Versorgung der Psoriasis mit systemischen Arzneimitteln geschlossen, indem reproduzierbare Kriterien für die Indikationsstellung zur Systemtherapie und deren differenzielle Auswahl definiert wurden. Die Kriterien stimmen grundsätzlich mit der aktuellen Fassung der S3-Leitlinie zur Therapie der Psoriasis überein.<span>⁸</span> Die Anwendung dieser praxisnahen Checkliste wird für die dermatologische Versorgung in Deutschland empfohlen. Wünschenswert ist eine nachfolgende Implementierungsforschung, mit der der Nutzen dieser Checkliste systematisch geprüft und die gewählten Kriterien gegebenenfalls adaptiert werden. Letzteres wird auch dann zu erwägen sein, wenn die erwartete Neuauflage der Konsensus-Kriterien für den Schweregrad der Psoriasis und die daraus abgeleiteten Therapieziele publiziert sind.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 2","pages":"281-283"},"PeriodicalIF":5.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15613_g","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kongresskalender 2025","authors":"","doi":"10.1111/ddg.15701","DOIUrl":"https://doi.org/10.1111/ddg.15701","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 2","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gruppierte Bläschen aus Nahost","authors":"Kaaja Mareile Baaske,&nbsp;Cord Sunderkötter,&nbsp;Andreas Montag","doi":"10.1111/ddg.15594_g","DOIUrl":"https://doi.org/10.1111/ddg.15594_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 2","pages":"212-217"},"PeriodicalIF":5.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}