Journal Der Deutschen Dermatologischen Gesellschaft最新文献

{"title":"Generalized pustular psoriasis in a patient with asthma following dupilumab and tezepelumab therapy.","authors":"Misaki Kawakami, Hana Takeshita, Atsushi Oda, Takeshi Namiki, Keiko Komatsuzaki, Yasunari Miyazaki, Naoko Okiyama","doi":"10.1111/ddg.15800","DOIUrl":"https://doi.org/10.1111/ddg.15800","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical propranolol and sirolimus in Pentravan: A promising non-systemic approach for Kaposi's sarcoma management.","authors":"Caterina Mariarosaria Giorgio, Vittorio Tancredi, Gaetano Licata, Giuseppe Argenziano, Eugenia Veronica Di Brizzi","doi":"10.1111/ddg.15822","DOIUrl":"https://doi.org/10.1111/ddg.15822","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A phase IIb single-center study to assess the efficacy of apremilast for the treatment of nummular eczema.","authors":"Alexander Böhner, Peter Seiringer, Viktoria Kleeberger, Danielle Rogner, Christian Oesterlin, Tilo Biedermann, Kilian Eyerich, Felix Lauffer","doi":"10.1111/ddg.15786","DOIUrl":"https://doi.org/10.1111/ddg.15786","url":null,"abstract":"<p><strong>Background: </strong>The pathogenesis of nummular eczema (NE) remains unclear, and no targeted therapy has been approved. Apremilast is a small molecule inhibitor targeting phosphodiesterase-4.</p><p><strong>Patients and methods: </strong>A phase IIb randomized, double-blind, placebo-controlled study evaluating the effects of apremilast or placebo in patients with NE. Patients received apremilast (30 mg BID) or placebo until week 16 followed by an open label phase in which all patients were treated with apremilast until week 32. The primary endpoint was the number of patients achieving an improvement in Physician's Global Assessment (PGA) by two or more points or an absolute PGA of 0 or 1 at week 16. Secondary endpoints included changes in skin physiology, life quality, or dermato-pathology.</p><p><strong>Results: </strong>33 patients were enrolled, of whom 31 were randomized to apremilast (n  =  15) or placebo (n  =  16). 1/15 (6.7%) patients in the apremilast group and 4/16 (25.0%) in the placebo group reached the primary endpoint (p  =  0.369). There was no difference between placebo and apremilast with regard to all secondary endpoints at week 16 and week 32. The safety profile was in accordance with the known safety profile of apremilast.</p><p><strong>Conclusion: </strong>Phosphodiesterase-4 inhibition by apremilast showed no beneficial effects for the treatment of NE.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of lepromatous leprosy in Germany.","authors":"Roman Saternus, Gisela Bretzel, Tamaz Tsulaia, Kristin Burckhardt, Krista Yordanova, Sophie Elisabeth Müller, Steffen Jahn, Thomas Vogt, Sophie Schneitler","doi":"10.1111/ddg.15801","DOIUrl":"https://doi.org/10.1111/ddg.15801","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin microbiome analysis of a junctional epidermolysis bullosa patient treated with genetically modified stem cells.","authors":"Alexander Dermietzel, Burcu Tosun, Mathilde Nguyen, Kai Wessel, Luise Rauer, Avidan U Neumann, Tobias Hirsch, Claudia Traidl-Hoffmann, Matthias Reiger, Claudia Hülpüsch, Maximilian Kueckelhaus","doi":"10.1111/ddg.15776","DOIUrl":"https://doi.org/10.1111/ddg.15776","url":null,"abstract":"<p><strong>Background and objective: </strong>Junctional epidermolysis bullosa (JEB) is a subtype of epidermolysis bullosa caused by mutations in the LAMB3 gene. We treated a patient with JEB using genetically corrected autologous epidermal cultures retrovirally transduced with the functional LAMB3 gene sequence. The objective of this study was to analyze the skin microbiome of this patient, with a particular focus on transgenic skin, and to compare the findings to the skin microbiome of healthy controls and patients with atopic dermatitis and well-documented microbial dysbiosis.</p><p><strong>Patients and methods: </strong>Skin microbiome analysis was performed on a JEB patient 72 months after combined gene and stem cell therapy. Skin swabs from age-matched healthy controls and atopic dermatitis patients were included from the ProRaD study of CK-CARE.</p><p><strong>Results: </strong>The transgenic skin had comparably high relative and absolute Staphylococcus (S.) aureus abundance to blistering and non-blistering skin of the JEB patient, while the total bacterial load was lower. In blistering skin of the JEB patient, higher bacterial load was driven by S. aureus.</p><p><strong>Conclusions: </strong>Our investigation confirms a unique microbiome composition in JEB, characterized by S. aureus driven bacterial overgrowth. The dysbiosis was not reversed in transgenic, non-blistering skin areas. However, the transgenic skin demonstrates stability in an environment of bacterial dysbiosis.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe onychauxis due to SAPHO syndrome.","authors":"Di Jin, Fanzhang Meng, Yuwei Wang, Yanli Xu, Yiwei Guan, Chen Li, Ming Li","doi":"10.1111/ddg.15779","DOIUrl":"https://doi.org/10.1111/ddg.15779","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recalcitrant Grover's disease treated with dupilumab: two long-term cases and review of the literature.","authors":"Michela Magnano, Alessandra Michelucci, Alessandro Mancin, Marco Romanelli, Valentina Dini","doi":"10.1111/ddg.15832","DOIUrl":"https://doi.org/10.1111/ddg.15832","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse plane xanthomas as the first manifestation of multiple myeloma.","authors":"Eleni Koutra, Elke Lusmöller, Hosam Ghanem, Astrid Aumann, Jens Atzpodien, Rudolf Stadler","doi":"10.1111/ddg.15807","DOIUrl":"https://doi.org/10.1111/ddg.15807","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supportive Schmerztherapie in der Dermatologie","authors":"Markus Werner,&nbsp;Waltraud Stromer,&nbsp;Svea Hüning,&nbsp;Carmen Loquai,&nbsp;Katharina Kähler,&nbsp;Laura Susok,&nbsp;Dorothée Nashan","doi":"10.1111/ddg.15624_g","DOIUrl":"https://doi.org/10.1111/ddg.15624_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 6","pages":"721-747"},"PeriodicalIF":5.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ivermectin-Creme 10 mg/g allein oder in Kombination mit oralem Doxycyclin bei Patienten mit perioraler Dermatitis (POD): eine retrospektive Fallserie","authors":"Martin Schaller,&nbsp;Daniela Lenders,&nbsp;Gabi Handgretinger,&nbsp;Andrea Gawaz","doi":"10.1111/ddg.15691_g","DOIUrl":"https://doi.org/10.1111/ddg.15691_g","url":null,"abstract":"&lt;p&gt;Sehr geehrte Herausgeber,&lt;/p&gt;&lt;p&gt;Die periorale Dermatitis (POD), auch rosazeaähnliche Dermatitis genannt, ist eine relativ häufige entzündliche, chronische Hauterkrankung des Gesichts.&lt;span&gt;&lt;sup&gt;1-3&lt;/sup&gt;&lt;/span&gt; Sie ist durch stechende, brennende, juckende und oft beidseitige erythematöse Papulovesikel oder Papulopusteln gekennzeichnet, die über Wochen bis Monate bestehen bleiben können. Obwohl der periorale Bereich am häufigsten betroffen ist, können die Hautveränderungen auch periorbital und paranasal auftreten. Die meisten Patienten (ca. 90 % der Fälle) sind Frauen im Alter zwischen 20 und 45 Jahren.&lt;span&gt;&lt;sup&gt;4, 5&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Die Ätiologie der POD ist nach wie vor ungeklärt. Man vermutet jedoch, dass sie multifaktoriell bedingt ist. Die Rolle topischer Steroide als Auslöser der POD ist gut belegt. Darüber hinaus werden übertriebene Hautpflege, insbesondere die langfristige Anwendung von Gesichtscremes, die zur Beeinträchtigung der epidermalen Barrierefunktion führt, sowie die Anwendung fluoridhaltiger Zahnpasta als mögliche Ursachen der POD vermutet.&lt;span&gt;&lt;sup&gt;1, 3&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Eine pathogenetische Rolle wird auch für mikrobielle Faktoren wie Infektionen mit &lt;i&gt;Fusobacterium&lt;/i&gt; spp., &lt;i&gt;Candida albicans&lt;/i&gt; und &lt;i&gt;Demodex folliculorum&lt;/i&gt; diskutiert. Dies stimmt mit der kürzlich veröffentlichten Beobachtung überein, dass Anti-COVID-19-Gesichtsmasken ein weiterer möglicher prädisponierender Faktor sein könnten, da sie über eine Erhöhung der Gesichtstemperatur eine Veränderung des Hautmikrobioms (Proliferation von &lt;i&gt;Staphylococcus epidermidis&lt;/i&gt; und/oder &lt;i&gt;Fusobacterium&lt;/i&gt; spp. und/oder &lt;i&gt;Demodex folliculorum&lt;/i&gt;) und der Durchlässigkeit der Hautbarriere bewirken.&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; Darüber hinaus fanden Dolenc-Voljc et al.&lt;span&gt;&lt;sup&gt;7&lt;/sup&gt;&lt;/span&gt; eine signifikant höhere Milbenprävalenz und Milbendichte bei Patienten mit POD, die zuvor mit topischen Steroiden behandelt worden waren im Vergleich zu POD-Patienten ohne Steroid-Vorbehandlung und zu gesunden Kontrollpersonen (für beide p &lt; 0,001).&lt;/p&gt;&lt;p&gt;Bislang beruht die Behandlung der POD hauptsächlich auf klinischen Erfahrungswerten, es gibt nur wenige gut kontrollierte Therapiestudien.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Zu den Therapieoptionen gehören das Absetzen und strikte Vermeidung aller topischen Steroide, Kosmetika und Salben (Nulltherapie), antientzündliche und antimikrobielle Externa mit Erythromycin, Metronidazol, Azelainsäure oder Pimecrolimus-Creme und systemische Antibiotika (Minocyclin, Tetracyclin, Doxycyclin) sowie in schweren Fällen orale Retinoide.&lt;span&gt;&lt;sup&gt;1, 2&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;In Anbetracht der potenziellen Rolle von &lt;i&gt;Demodex folliculorum&lt;/i&gt; in der Pathogenese der POD wie bei der Rosazea erscheint die Behandlung mit topischem Ivermectin, einem makrozyklischen Lakton-Disaccharid-Antiparasitikum, sinnvoll. Ivermectin 10 mg/g Creme (Soolantra&lt;sup&gt;®&lt;/sup&gt;, Galderma Laboratorium GmbH) einmal täglich aufgetragen ist in den USA und in Europa seit 2014 bezi","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 6","pages":"759-762"},"PeriodicalIF":5.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15691_g","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}