Journal Der Deutschen Dermatologischen Gesellschaft最新文献

Well-being in German patients with vitiligo in genital and visible areas - a pilot study. 德国白癜风患者生殖器和可见部位的健康状况-一项试点研究。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-10-08 DOI: 10.1111/ddg.15891

Janne Ohlenbusch, Rachel Sommer, Kerstin Steinbrink, Markus Böhm

{"title":"Well-being in German patients with vitiligo in genital and visible areas - a pilot study.","authors":"Janne Ohlenbusch, Rachel Sommer, Kerstin Steinbrink, Markus Böhm","doi":"10.1111/ddg.15891","DOIUrl":"https://doi.org/10.1111/ddg.15891","url":null,"abstract":"Background: Only a few studies exist on the psychosocial impact of vitiligo in German patients, in particular those affected in genital and visible body areas.Methods: This monocentric pilot study aimed to assess well-being of adult patients with vitiligo and to compare sex, age, and clinical characteristics between patients with and without genital, facial and hand involvement. Well-being was assessed using the WHO-5 questionnaire and quality of life with the Dermatology Life Quality Index (DLQI). Furthermore, psychometric properties of the WHO-5 well-being index were tested.Results: In total, 110 patients (mean age ± SD: 47.5 ± 14.7 years; 54.5% female; 95.5% with non-segmental vitiligo) were included. The WHO-5 mean score was 13.3, with 46 patients (42.2%) having a score < 13, indicating reduced well-being. Sixteen patients (14.7%) had a WHO-5 score < 7, indicating a high probability of depression. No significant differences in WHO-5 or DLQI scores were found between patients with vs without genital, facial, and hand involvement. Psychometric properties were confirmed to be good.Conclusions: Our findings emphasize the psychosocial impact of vitiligo in German patients, as reflected by reduced well-being, and suggest the usefulness of the WHO-5 as a simple psychosocial screening tool for routine care.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manifestation of morphea in a patient with myasthenia gravis under therapy with zilucoplan. 重症肌无力患者在zilucoplan治疗下的睡眠表现。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-10-07 DOI: 10.1111/ddg.15919

Phoebe Wellmann, Jana Zschüntzsch, Michael P Schön, Rotraut Mössner

引用次数: 0

HPV42 - a human papillomavirus classified as a low-risk type with oncogenic potential. HPV42 -一种人类乳头瘤病毒，被归类为具有致癌潜力的低风险型。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-10-06 DOI: 10.1111/ddg.15981

Sven Niklas Burmann, Ulrike Wieland, Steffi Silling, Frank Oellig, David Chromy, Julia Hyun, Thilo Gambichler, Alexander Kreuter

{"title":"HPV42 - a human papillomavirus classified as a low-risk type with oncogenic potential.","authors":"Sven Niklas Burmann, Ulrike Wieland, Steffi Silling, Frank Oellig, David Chromy, Julia Hyun, Thilo Gambichler, Alexander Kreuter","doi":"10.1111/ddg.15981","DOIUrl":"https://doi.org/10.1111/ddg.15981","url":null,"abstract":"Human papillomavirus (HPV) type 42 is a rare HPV type currently classified as \"low-risk\" and belongs to the alpha genus. It has primarily been detected in benign vulvar papillomas and is predominantly associated with benign lesions such as anogenital warts. However, in very rare cases, HPV42 has also been identified in invasive genital tumors, particularly cervical carcinomas. In the case series presented here, HPV42 was detected in anogenital warts, a digital squamous cell carcinoma in situ, and a lymphogenously metastasized digital papillary adenocarcinoma (DPA). In the latter tumor entity, HPV42 was recently identified as the potential causative agent. Depending on the infected cell population, HPV42 can give rise to both benign lesions (anogenital warts and the rare cervicovaginal \"seborrheic keratosis-like\" lesion) and malignant lesions (anogenital and digital carcinomas, as well as the highly aggressive DPA). HPV42 can therefore be considered as potentially carcinogenic. With the currently available nonavalent HPV vaccine over 90% of HPV-related tumors and anogenital warts can be prevented, but not HPV42-induced lesions. These tumors will therefore not be suppressed by the current vaccination programs, even not in countries with high vaccination rates.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute lymphoblastic B-cell leukemia or CAR-T cell related skin changes - a relevant diagnostic challenge. 急性淋巴母细胞b细胞白血病或CAR-T细胞相关的皮肤变化-一个相关的诊断挑战。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-10-06 DOI: 10.1111/ddg.15931

Farzan Solimani, Amrei Dilling, Konrad Heisterkamp, Frederik Damm, Olaf Penack, Christian Oberender, Philipp Le-Coutre, Martina Rudelius, Kamran Ghoreschi, Alexander Nast

引用次数: 0

Long-standing, therapy-refractory plaques with a reticular pattern. 具有网状结构的长期难治性斑块。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-10-06 DOI: 10.1111/ddg.15914

Ana-Lee Gerdes, Alexander Kreuter, Uwe Hillen, Jörg Schaller, Julia Hyun, Valentina Laura Müller

引用次数: 0

Complete clearance of paraneoplastic erythema annulare centrifugum following bortezomib monotherapy. 硼替佐米单药治疗后完全清除离心环形副肿瘤红斑。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-10-06 DOI: 10.1111/ddg.15903

Antigona Aliu, Ulrich Peter Wehry, Niklas Stuka, Frank Oellig, Thilo Gambichler, Alexander Kreuter

引用次数: 0

Integrating social media into modern dermatology - a cross-sectional study. 将社交媒体融入现代皮肤病学——一项横断面研究。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-10-05 DOI: 10.1111/ddg.15911

Maximilian Lammer, Marina Wanner, Paul Bellmann, Magdalena Seidl-Philipp, Matthias Schmuth

{"title":"Integrating social media into modern dermatology - a cross-sectional study.","authors":"Maximilian Lammer, Marina Wanner, Paul Bellmann, Magdalena Seidl-Philipp, Matthias Schmuth","doi":"10.1111/ddg.15911","DOIUrl":"https://doi.org/10.1111/ddg.15911","url":null,"abstract":"Background and objective: Social media is increasingly establishing itself as an important source of information for skin health. Although demand among users is high, very few dermatologists outside the Anglo-American region use these platforms to provide patient information, and the majority of content is provided by non-medical sources. This study investigated the influence of social media on skincare and preventive behavior among young adults, and the relevance of medically qualified content.Methods: An anonymized 34-item online questionnaire was distributed to 454 students at the University of Innsbruck, assessing social media usage, skincare routines, prevention behavior, and perception of dermatological content. Descriptive and inferential statistics (chi-square tests, p < 0.05) were applied.Results: A significant association was found between time spent on social media and perceived impact on personal skin health (p = 0.014). Participants exposed to dermatologist-created content were significantly more likely to follow a skincare routine (p < 0.001). The majority expressed a desire for more professionally qualified information.Conclusions: Social media offers significant potential for providing information about skin conditions and educating patients. A more comprehensive presence of content reviewed by medical professionals may help minimize the spread of misinformation and promote health education, especially among young users.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sclerosing diseases of the skin. 硬化性皮肤病皮肤硬化性疾病

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-10-01 DOI: 10.1111/ddg.15835

Yasamin Kalantari, Katharina Meier, Kamran Ghoreschi, Maria Kinberger, Farzan Solimani

引用次数: 0

Brentuximab vedotin and radiotherapy for CD30-positive cutaneous T-cell lymphoma - a retrospective multicenter analysis. Brentuximab vedotin和放疗治疗cd30阳性皮肤t细胞淋巴瘤-一项回顾性多中心分析

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-09-30 DOI: 10.1111/ddg.15897

Patrick Schummer, Caroline Glatzel, Philipp Schrüfer, Ingulf Lawrenz, Gabor Dobos, Ulrike Wehkamp, Svea Hüning, René Stranzenbach, Jan P Nicolay, Matthias Goebeler, Marion Wobser

{"title":"Brentuximab vedotin and radiotherapy for CD30-positive cutaneous T-cell lymphoma - a retrospective multicenter analysis.","authors":"Patrick Schummer, Caroline Glatzel, Philipp Schrüfer, Ingulf Lawrenz, Gabor Dobos, Ulrike Wehkamp, Svea Hüning, René Stranzenbach, Jan P Nicolay, Matthias Goebeler, Marion Wobser","doi":"10.1111/ddg.15897","DOIUrl":"https://doi.org/10.1111/ddg.15897","url":null,"abstract":"Background and objectives: While brentuximab vedotin (BV) and radiotherapy (RTx) are established treatment options for CD30-positive cutaneous T-cell lymphoma (CTCL), data on their simultaneous or sequential use regarding efficacy and tolerability remain scarce. In this retrospective analysis, we evaluated the combination of BV and RTx in patients with CD30-positive CTCL.Patients and methods: We included 14 CD30-positive CTCL patients from six German cancer centers receiving BV; RTx was initiated within a timeframe of 3 months prior/after BV treatment. RTx was mainly applied as a low-dose scheme.Results: Adverse events of any grade occurred in 71% of patients, most commonly peripheral neuropathy, neutropenia, and radiodermatitis. Thirteen patients achieved a complete or partial remission as best overall response, however, 50% of all patients showed disease progression. At a median follow-up of 14.4 months, median progression-free survival was 12.0 months, with a 1-year rate of 34.0%.Conclusions: The simultaneous or sequential use of RTx during BV treatment was feasible and well tolerated. Future randomized investigations are needed to identify the benefits of this combination treatment regimen as well as adequate dosing of BV and RTx in a prospective manner.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of trichoscopic images using deep neural networks for the diagnosis and activity assessment of alopecia areata - a retrospective study. 利用深度神经网络对斑秃的诊断和活动性评估的毛发镜图像分析-一项回顾性研究。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-09-30 DOI: 10.1111/ddg.15847

Raffaele Dante Caposiena Caro, Victoria Orlova, Nicola Di Meo, Iris Zalaudek

{"title":"Analysis of trichoscopic images using deep neural networks for the diagnosis and activity assessment of alopecia areata - a retrospective study.","authors":"Raffaele Dante Caposiena Caro, Victoria Orlova, Nicola Di Meo, Iris Zalaudek","doi":"10.1111/ddg.15847","DOIUrl":"https://doi.org/10.1111/ddg.15847","url":null,"abstract":"Background and objectives: Alopecia areata (AA) is an autoimmune disease that provokes hair loss. The diagnosis is made clinically with the support of trichoscopy. However, trichoscopy requires specialized training. Deep learning models may support the diagnosis and management of AA. The aim of this study is to develop a deep learning framework to diagnose AA and to determine the AA level of activity.Patients and methods: A retrospective analysis of trichoscopic images collected from patients with scalp diseases and healthy controls was conducted to develop a two-step deep learning framework. In Step-1, the model aimed to distinguish AA disease from both other scalp diseases and control healthy subjects. In Step-2, we intended to train a model that recognized the AA level of activity dividing the AA dataset into active, inactive, and regrowth.Results: In Step-1 an overall accuracy of 88.92% and an F1 score of 88.17% were achieved with an AA discriminatory capacity of 90.98%. In Step-2 an accuracy of 83.33% and an F1 score of 83.36% were reached.Conclusions: Our study highlighted for the first time the potential use of artificial intelligence in the diagnosis and staging of AA allowing more accurate diagnoses and better care.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0