Maria Rosa Burg, Inga Hansen, Leopold Konstantin Torster, Stefan Werner Schneider
{"title":"Occlusive cutaneous vasculopathies: rare differential diagnoses.","authors":"Maria Rosa Burg, Inga Hansen, Leopold Konstantin Torster, Stefan Werner Schneider","doi":"10.1111/ddg.15543","DOIUrl":"https://doi.org/10.1111/ddg.15543","url":null,"abstract":"<p><p>In addition to erythematous plaques, nodules, ulcerations, and necrosis, retiform purpura and livedo racemosa are indications of occlusive cutaneous vasculopathies. In contrast to cutaneous vasculitis, occlusive cutaneous vasculopathies primarily lead to vascular occlusion of the skin and only secondarily to signs of vascular inflammation. The lower legs are typically affected, but especially in the presence of acral skin changes, occlusive cutaneous vasculopathies should also be considered. Various stimuli can trigger occlusive cutaneous vasculopathies, including systemic or vascular coagulopathies, emboli, platelet or erythrocyte aggregates, cold-dependent gelling and agglutination of immunoglobulins, or, less commonly, medications.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Conrad Hempel, Anna-Theresa Seitz, Viktor Schnabel, Till Mittank-Weidner, Jan-Christoph Simon, Sonja Grunewald
{"title":"Combination of rhinoshave and fractional ablative CO<sub>2</sub> laser therapy for fine contouring of pronounced rhinophyma - A monocentric retrospective study with long-term follow-up.","authors":"Conrad Hempel, Anna-Theresa Seitz, Viktor Schnabel, Till Mittank-Weidner, Jan-Christoph Simon, Sonja Grunewald","doi":"10.1111/ddg.15692","DOIUrl":"https://doi.org/10.1111/ddg.15692","url":null,"abstract":"<p><strong>Background: </strong>Currently, there are no effective drug therapy options that lead to the regression of rhinophyma. Many surgical procedures for treating rhinophyma have been published; however, there are limited data on their effectiveness. In addition, these treatment options often lead to persistent hypopigmented scarring if excessive ablation or heat is applied.</p><p><strong>Patients and methods: </strong>To prevent excessively deep ablation and enable precise nasal contouring, a combination therapy was developed, integrating classic rhinoshave for coarse ablation followed by laser fine contouring. Fractional ablation was performed to minimize heat accumulation. Here, we report on 45 patients with pronounced rhinophyma who underwent this treatment at the Dermatology Clinic of Leipzig University between 2016 and 2024. The median follow-up period was 51 months (range: 6-96 months).</p><p><strong>Results: </strong>The majority of the patients were either very satisfied or satisfied with the postoperative outcome (n = 26; 92.3%). One case of postoperative hemorrhage was reported (2.2%). There was no wound infection observed, and the recurrence rate was 17.9%.</p><p><strong>Conclusions: </strong>The combination of rhinoshave and fractional ablative CO<sub>2</sub> laser treatment is a feasible and safe therapeutic procedure and ensures high patient satisfaction with a low recurrence rate.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful treatment of subacute cutaneous lupus erythematosus with the TYK-2 inhibitor deucravacitinib in a patient with concomitant psoriasis vulgaris.","authors":"Katharina Assaf, Selina Patt, Valentin Sebastian Schäfer, Jörg Wenzel, Natalija Novak, Dagmar Wilsmann-Theis","doi":"10.1111/ddg.15705","DOIUrl":"https://doi.org/10.1111/ddg.15705","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nessr Abu Rached, Riina Käpynen, Yannik Haven, Lennart Ocker, Carolin Frost, Eggert Stockfleth, Falk G Bechara
{"title":"Characteristics of squamous cell carcinoma on hidradenitis suppurativa lesions - a case series.","authors":"Nessr Abu Rached, Riina Käpynen, Yannik Haven, Lennart Ocker, Carolin Frost, Eggert Stockfleth, Falk G Bechara","doi":"10.1111/ddg.15708","DOIUrl":"https://doi.org/10.1111/ddg.15708","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dermatological indicator condition guided testing for HIV: experience of a reference dermatology center.","authors":"Jorinta Jokubaitė, Eglė Janušonytė, Tadas Raudonis","doi":"10.1111/ddg.15680","DOIUrl":"https://doi.org/10.1111/ddg.15680","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abstract","authors":"","doi":"10.1111/ddg.15735_g","DOIUrl":"https://doi.org/10.1111/ddg.15735_g","url":null,"abstract":"<p>Rupesh Paudel<sup>1,2*</sup>, Lena F Sorger<sup>1*</sup>, Anita Hufnagel<sup>1</sup>, Mira Pasemann<sup>1</sup>, Tamsanqa Hove<sup>1,3</sup>, André Marquardt<sup>1,4</sup>, Susanne Kneitz<sup>5</sup>, Andreas Schlosser<sup>6</sup>, Caroline Kisker<sup>3</sup>, Jochen Kuper<sup>3#</sup>, Svenja Meierjohann<sup>1,4#</sup></p><p><sup>1</sup>Institute of Pathology, University of Würzburg, 97080 Würzburg, Germany</p><p><sup>2</sup>Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany.</p><p><sup>3</sup>Rudolf Virchow Center for Integrative and Translational Bioimaging, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany</p><p><sup>4</sup>Comprehensive Cancer Center Mainfranken, University of Würzburg, 97080 Würzburg, Germany</p><p><sup>5</sup>Department of Biochemistry and Cell Biology, University of Würzburg, 97074 Würzburg, Germany</p><p><sup>6</sup>Rudolf Virchow Center for Integrative and Translational Bioimaging, Mass Spectrometry Division, University of Würzburg, 97080 Würzburg, Germany</p><p><sup>#</sup>corresponding authors:</p><p>J Kuper (<span>[email protected]</span>)</p><p>S Meierjohann (<span>[email protected]</span>)</p><p>*These authors contributed equally to this work</p><p><b>Abstract</b></p><p>Germline mutations in the DNA repair helicase XPD cause the diseases xeroderma pigmentosum (XP), trichothiodystrophy (TTD) and Cockayne syndrome. XP patients bear an increased risk of developing skin cancer including melanoma, even at young age. This is not observed for TTD patients despite DNA repair defects. To examine whether TTD cells harbor features counteracting tumorigenesis, we developed a TTD melanoma cell model containing the XPD variant R722W. Intriguingly, TTD melanoma cells exhibited reduced pro-tumorigenic features and an increased signature of the melanocyte lineage differentiation factor MITF, which went along with a strong basal upregulation of REDD2, an inhibitor of the mTOR/S6K/4EBP1 dependent protein translation machinery. REDD2 levels were partially driven by MITF, increased under UV exposure, and contributed to the reduced melanoma proliferation. To investigate whether similar processes are affected in melanocytes - the progenitor cell type of melanoma - we developed a TTD melanocyte model. Again, the MITF gene signature was increased, this time without affecting REDD2 expression. However, protein translation analyses revealed reduced ribosomal protein synthesis particularly in R722W melanocytes after UV stress, indicating a compromised protein translation machinery. Impaired protein translation was also demonstrated for the TTD XPD variant A725P, but not for the XPD variant D234N that causes XP. Concludingly, although effectors of R722W partially differ between melanoma cells and melanocytes, they result in translation inhibition and therefore reduced fitness, particularly under UV exposure. This may limit the probability of UV-driven","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 S2","pages":"3-20"},"PeriodicalIF":5.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15735_g","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autorenverzeichnis","authors":"","doi":"10.1111/ddg.15794","DOIUrl":"https://doi.org/10.1111/ddg.15794","url":null,"abstract":"<p>Abiona, A. 5, 14</p><p>Anazodo, A. 9</p><p>Apelt, K. 19</p><p>Arseni, L. 4</p><p>Baghoomian, W. 13</p><p>Balgos, K. 5</p><p>Berneburg, M. 10, 15</p><p>Bhattacharjee, R. 14</p><p>Bini, L. 4</p><p>Björn, S. 10</p><p>Bodi, I. 14</p><p>Boeckmann, L. 8</p><p>Bogner, C. 10</p><p>Bohr, V. A. 17</p><p>Boissière, T. 19</p><p>Botta, E. 3, 9, 17</p><p>Branca, G. 4, 17</p><p>Brevi, F. 9</p><p>Cepeda-Valdes, R. 13</p><p>Cimmaruta, C. 10</p><p>Compe, E. 4</p><p>Cramer, P. 19</p><p>Craythorne, E. 14</p><p>D. Schärer, O. D. 19</p><p>D'Souza, A. 19</p><p>Dangeleit, S. 14</p><p>de Lint, K. 19</p><p>Dell'Ambra, E. 3</p><p>DiDonato, N. 8</p><p>DiGiovanna, J. J. 13, 18</p><p>Diletta, G. 6</p><p>Elena, P. 6</p><p>Emma, V. 6</p><p>Emmert, S. 8</p><p>Erden, N. 15</p><p>Farnung, L. 13</p><p>Fassihi, H. 5, 12, 14, 15</p><p>Ferri, D. 4, 17</p><p>Ficht, P.-K. 8</p><p>Ficht, P. 8</p><p>Filippi, S. 7</p><p>Fleszar, Z. 14</p><p>Gandolfi, E. 4, 17</p><p>Garcia-Moreno, H. 14</p><p>Garrood, I. 5, 14</p><p>Giunti, P. 5, 14</p><p>Gronwald, W. 10</p><p>Guida, G. 17</p><p>Guzzon, D. 7</p><p>Hasanhodzic, M. 8</p><p>Hempel, M. 8</p><p>Henshaw, T. 5, 14</p><p>Herlihy, A. E. 19</p><p>Hove, T. 3</p><p>Hufnagel, A. 3</p><p>Iben, S. 9</p><p>Kamenisch, Y. 10</p><p>Kashyap, K. 19</p><p>Keogh, R. 5</p><p>Khan, S. G. 13, 18</p><p>Kim, H.-S. 19</p><p>Kirdök, I. 19</p><p>Kisker, C. 3</p><p>Kneitz, S. 3</p><p>Kokic, G. 19</p><p>Kraemer, K. H. 13, 18</p><p>Krutmann, J. 14</p><p>Kümmecke, M. 13</p><p>Kuper, J. 3</p><p>Kuschal, C. 13</p><p>Kuzmich, O. 8</p><p>Lajus, T. B. P. 12</p><p>Landi, C. 4</p><p>Langan, S. M. 5</p><p>Langbehn, D. R. 14</p><p>Lans, H. 17</p><p>Lanzafame, M. 3, 4, 17</p><p>Laugel, V. 10</p><p>Lee, M. P. 13</p><p>Lehmann, A. R. 5, 14</p><p>Lehmann, A. 9, 15</p><p>Lemken, A. 8</p><p>Ljungman, M. 19</p><p>Lombardi, A. 3</p><p>Luca, P.-D.-S. 6</p><p>Luijsterburg, M. S. 19</p><p>Maga, G. 4</p><p>Majora, M. 14</p><p>Manes, M. A. 14</p><p>Marquardt, A. 3</p><p>Marteijn, J. A. 17</p><p>Martin, L. 9, 10</p><p>Martin, L. K. 9</p><p>Maver, A. 8</p><p>McLoone, J. 9</p><p>Meierjohann, S. 3</p><p>Menck, C. F. M. 12</p><p>Mevissen, T. E. T. 13</p><p>Mitter, R. 19</p><p>Mohammed, S. 5, 14</p><p>Moreno, N. N. 19</p><p>Moriwaki, S. 16</p><p>Morley, A. M. S. 5, 14</p><p>Naik, H. 14</p><p>Nardo, T. 3, 17</p><p>Nikolaev, S. 12, 19</p><p>Nishigori, C. 12, 16</p><p>Orioli, D. 3. 4. 9, 17</p><p>Paccosi, E. 7</p><p>Palfrey, J. 5</p><p>Panzer, R. 8</p><p>Paolini, R. 10</p><p>Paolino, A. 5</p><p>Park, J. 19</p><p>Pasemann, M. 3</p><p>Paudel, R. 3</p><p>Peverali, F. A. 4</p><p>Porrmann, J. 8</p><p>Primal, D. L. 6</p><p>Proietti De Santis, L. 7</p><p>Rajabi, F. 12</p><p>Ricchetti, M. 10</p><p>Riva, V. 4</p><p>Rodríguez-Martínez, M. 19</p><p>Rossi, A. 14</p><p>Sabatella, M. 17</p><p>Salas-Alanis, J. 13</p><p>Sarasin, A. 12, 19</p><p>Sarkany, R. 18</p><p>Sarkany, R. P. E. 14</p><p>Schlosser, A. 3</p><p>Schmid, E. W. 13</p><p>Scholz, T. 8</p><p>Schumacher, B. 15</p><p>Silvia, F. 6</p><p>Sorger, L. 3</p><p>So","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 S2","pages":"21-22"},"PeriodicalIF":5.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15794","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Murat Cavdar, Damian Kostner, Mathias Drach, Veronique Touzeau-Römer, Katharina Grabmeier-Pfistershammer, Johanna Strobl
{"title":"A case of argyria as consequence of alternative medical treatment.","authors":"Murat Cavdar, Damian Kostner, Mathias Drach, Veronique Touzeau-Römer, Katharina Grabmeier-Pfistershammer, Johanna Strobl","doi":"10.1111/ddg.15707","DOIUrl":"https://doi.org/10.1111/ddg.15707","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}