Journal Der Deutschen Dermatologischen Gesellschaft最新文献

Clinical and histopathological features of advanced cutaneous squamous cell carcinoma with varying responses to cemiplimab. 晚期皮肤鳞状细胞癌的临床和组织病理学特征以及对塞米单抗的不同反应。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2024-11-03 DOI: 10.1111/ddg.15551

Conrad Hempel, Gabriela Vladimirova, Susanne Horn, Lars-Christian Horn, Mirjana Ziemer

{"title":"Clinical and histopathological features of advanced cutaneous squamous cell carcinoma with varying responses to cemiplimab.","authors":"Conrad Hempel, Gabriela Vladimirova, Susanne Horn, Lars-Christian Horn, Mirjana Ziemer","doi":"10.1111/ddg.15551","DOIUrl":"https://doi.org/10.1111/ddg.15551","url":null,"abstract":"Background: Most patients with unresectable locally advanced cutaneous squamous cell carcinoma (cSCC) benefit from cemiplimab, but some do not respond. Our study aims to identify clinical and histopathological features predicting response to cemiplimab.Patients and methods: We analyzed 15 patients treated with cemiplimab, assessing clinical, demographic, histopathological, and immunohistochemical characteristics and correlating them with treatment response. Furthermore, effectiveness and safety were evaluated in our cohort.Results: Our cohort included 12 males and 3 females, with a mean age of 78.1 years. The majority of tumors, accounting for 66.7%, were located in the head and neck region. Treatment was well-tolerated, with only one grade 3 colitis. There was no correlation between immune-related adverse events and treatment response. Non-responders were younger (69.4 vs. 82.5 years). A history of hematological malignancy correlated with poorer response. High mitotic rate, poor tumor differentiation, high vimentin and p53, and low E-cadherin expression were associated with worse response. Conversely, higher intratumoral inflammatory infiltrate density, presence of necrotic areas, and lower mismatch repair-protein staining correlated with better response.Conclusions: Cemiplimab is a safe and effective therapy, particularly in elderly patients. Well-differentiated tumors with low proliferative index, intratumoral inflammatory infiltrate, and tumor necrosis may predict better clinical response.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A garden as a habitat of rare keratinophilic fungi - relevant to man and beast. 作为珍稀嗜角质真菌栖息地的花园--与人类和野兽息息相关。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2024-11-01 Epub Date: 2024-08-06 DOI: 10.1111/ddg.15526

Jochen Brasch, Karen Voss, Katharina Antonia Langen, Alexander Achenbach

引用次数: 0

Screening of psoriatic arthritis by dermatologists - a German nationwide survey. 皮肤科医生对银屑病关节炎的筛查--德国全国性调查。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2024-11-01 Epub Date: 2024-09-20 DOI: 10.1111/ddg.15486

Andreas Pinter, Matthias Hofmann, Roland Kaufmann, Jutta Müller-Stahl, Anke König

{"title":"Screening of psoriatic arthritis by dermatologists - a German nationwide survey.","authors":"Andreas Pinter, Matthias Hofmann, Roland Kaufmann, Jutta Müller-Stahl, Anke König","doi":"10.1111/ddg.15486","DOIUrl":"10.1111/ddg.15486","url":null,"abstract":"Background and objectives: Up to 30% of psoriasis (PsO) is clinically associated with psoriatic arthritis (PsA). A large proportion of new onset of PsA is diagnosed at a later stage, despite the necessity of early effective treatment to prevent structural damage. This study aimed to identify the routine screening practices used for PsA in patients with PsO.Patients and methods: This non-interventional, prospective, epidemiological, cross-sectional study conducted in Germany focuses on screening activity and treatment selection of dermatological practices in suspected PsA. Descriptive statistics and patient characteristics were analyzed for different center types.Results: One hundred ninety-five patients from 34 office-based physicians, five non-university hospitals, and nine university hospitals were included. Questionnaires or imaging techniques were not routinely used (< 45%). Especially, ultrasounds (≤ 5%) and MRIs (< 6.3%) were rarely performed. Between 30% and 75% of suspected PsA could be confirmed. Referral to rheumatologists and/or appropriate therapy initiation were the most frequent consequences.Conclusions: Results of this study reflect the status of PsA screening activity by dermatologists. Imaging techniques, particularly ultrasound or MRIs to detect early forms of PsA, were inadequately used, which may have contributed to continued underdiagnoses. Collaboration between dermatologists and rheumatologists should be reviewed with a view to improving effective PsA screening.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological characteristics of low-dose methotrexate-induced epidermal dysmaturation: A study of 22 patients. 低剂量甲氨蝶呤诱发表皮发育不良的临床病理特征：对 22 名患者的研究。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2024-11-01 Epub Date: 2024-09-16 DOI: 10.1111/ddg.15537

Valentin Aebischer, Matthias Hahn, Daniela Lenders, Gisela Metzler, Martin Schaller, Toni Silber, Stephan Forchhammer

{"title":"Clinicopathological characteristics of low-dose methotrexate-induced epidermal dysmaturation: A study of 22 patients.","authors":"Valentin Aebischer, Matthias Hahn, Daniela Lenders, Gisela Metzler, Martin Schaller, Toni Silber, Stephan Forchhammer","doi":"10.1111/ddg.15537","DOIUrl":"10.1111/ddg.15537","url":null,"abstract":"Background and objective: Erosions of the skin and mucous membranes with epidermal dysmaturation are a known side effect of cytostatic chemotherapy regimens and can also be observed during low-dose methotrexate (MTX) therapy. The study aimed to delineate the clinical and histopathological alterations.Patients and methods: A database search of the archive for dermatopathology was conducted, identifying 22 patients who developed epidermal dysmaturation on low-dose MTX. Clinical and laboratory changes, along with an array of histologic parameters were analyzed and statistically evaluated using SPSS.Results: Patients were predominantly female with a mean age of 69.1 years. The main indications were psoriasis vulgaris and rheumatoid arthritis. Clinically, patients mostly presented erosive plaques at the injection site, on mucosal surfaces, and disseminated lesions. Most patients showed normal laboratory values. Histopathologically, key findings included enlarged keratinocytes with pale cytoplasm and enlarged nuclei with prominent nucleoli, along with the degeneration of the basal layer. Consistent observations in the dermal compartment included infiltration of neutrophilic granulocytes, lymphocytes, and histiocytes.Conclusions: This study proposes clinicopathological criteria for the diagnosis of MTX-associated skin toxicity, aiming to increase awareness among clinicians and pathologists for early diagnosis. Early recognition can prevent potentially life-threatening progression.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S3 guideline: Diagnosis and treatment of epidermal necrolysis (Stevens-Johnson syndrome and toxic epidermal necrolysis) - Part 2: Supportive therapy of EN in the acute and post-acute stages. S3 指南：表皮坏死溶解症（史蒂文斯-约翰逊综合征和中毒性表皮坏死溶解症）的诊断和治疗--第 2 部分：表皮坏死溶解症急性期和急性期后的支持疗法。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2024-11-01 Epub Date: 2024-10-17 DOI: 10.1111/ddg.15516

Maren Paulmann, Ruben Heuer, Thorsten Annecke, Björn Behr, Katharina Boch, Anja M Boos, Knut Brockow, Lars E French, Jochen Gille, Verena Gundlach, Bernd Hartmann, Peter Höger, Silke C Hofmann, Tobias Klein, Marcus Lehnhardt, Yvonne Liß, Philip Maier, Philipp Mandel, Nicos Marathovouniotis, Finnja Marlok, Hans Mittelviefhaus, Uwe Pleyer, Marie Pradeau, Katharina Rall, Siegbert Rieg, Heike Rittner, Frank Sander, Stefan Schnitzler, Christina Schut, Annette Stolle, Artem Vorobyev, Bettina Wedi, Johannes Weiss, Maximilian Zepp, Mirjana Ziemer, Maja Mockenhaupt, Alexander Nast

{"title":"S3 guideline: Diagnosis and treatment of epidermal necrolysis (Stevens-Johnson syndrome and toxic epidermal necrolysis) - Part 2: Supportive therapy of EN in the acute and post-acute stages.","authors":"Maren Paulmann, Ruben Heuer, Thorsten Annecke, Björn Behr, Katharina Boch, Anja M Boos, Knut Brockow, Lars E French, Jochen Gille, Verena Gundlach, Bernd Hartmann, Peter Höger, Silke C Hofmann, Tobias Klein, Marcus Lehnhardt, Yvonne Liß, Philip Maier, Philipp Mandel, Nicos Marathovouniotis, Finnja Marlok, Hans Mittelviefhaus, Uwe Pleyer, Marie Pradeau, Katharina Rall, Siegbert Rieg, Heike Rittner, Frank Sander, Stefan Schnitzler, Christina Schut, Annette Stolle, Artem Vorobyev, Bettina Wedi, Johannes Weiss, Maximilian Zepp, Mirjana Ziemer, Maja Mockenhaupt, Alexander Nast","doi":"10.1111/ddg.15516","DOIUrl":"10.1111/ddg.15516","url":null,"abstract":"Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare, predominantly drug-induced, acute life-threatening diseases of skin and mucosae. SJS and TEN are nowadays considered as variants of one disease entity with varying degrees of severity called epidermal necrolysis (EN). EN is associated with high morbidity and mortality and constitutes a major disease burden for affected patients. The guideline \"Diagnosis and treatment of epidermal necrolysis (Stevens-Johnson syndrome and toxic epidermal necrolysis)\" was developed under systematic consideration of existing scientific literature and in a formal consensus process according to regulations issued by the Association of Scientific Medical Societies in Germany (AWMF) to establish an evidence-based framework to support clinical decision-making. The interdisciplinary guideline commission consisted of representatives from various specialist societies and of patient representatives. The guideline is aimed at specialists in the fields of dermatology, ophthalmology, plastic surgery, intensive care, and pediatrics in hospitals and offices, as well as other medical specialties involved in the diagnosis and treatment of EN. The guideline is also aimed at patients, their relatives, insurance funds, and policymakers. The second part is concerned with the topics of supportive therapy in the acute phase of EN and outpatient follow-up treatment.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary cutaneous nocardiosis of both eyebrows due to eyebrow tattooing. 因纹眉引起的双眉原发性皮肤念珠菌病。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2024-11-01 Epub Date: 2024-08-09 DOI: 10.1111/ddg.15508

Chao-Chao Ji, Yue Mou, Yin Lv, Yue-Lin Li, Fan-Xiang Wang, Jia-Qi Liu, Wen-Hao Cheng, Ren-Qiong Chen, Wen-Long Hu

引用次数: 0

Porocarcinoma of the foot: How would you handle this case without Mohs surgery? 足部肝癌：如果没有莫氏手术，您会如何处理这个病例？

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI: 10.1111/ddg.15536

Giovanni Marco D'Agostino, Tommaso Bianchelli, Alfredo Giacchetti, Donatella Brancorsini

引用次数: 0

In vitro diagnostics of drug allergies. 药物过敏的体外诊断。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2024-11-01 Epub Date: 2024-10-16 DOI: 10.1111/ddg.15466

Andreas Glässner, Katharina Weßollek, Amir S Yazdi, Bernhardt Sachs

引用次数: 0

Pegylated interferon-α2a in cutaneous T-cell lymphoma - a multicenter retrospective data analysis with 70 patients. 治疗皮肤T细胞淋巴瘤的聚乙二醇干扰素α2a--对70名患者的多中心回顾性数据分析。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2024-11-01 Epub Date: 2024-10-02 DOI: 10.1111/ddg.15511

Inga Hansen-Abeck, Glenn Geidel, Finn Abeck, Julian Kött, Rohat Cankaya, Gabor Dobos, Christina Mitteldorf, Jan P Nicolay, Jana D Albrecht, Christian Menzer, Elisabeth Livingstone, Miriam Mengoni, Andreas D Braun, Marion Wobser, Claus-Detlev Klemke, Sabine Tratzmiller, Chalid Assaf, Patrick Terheyden, Kai-Christian Klespe, Stefan W Schneider, Nina Booken

{"title":"Pegylated interferon-α2a in cutaneous T-cell lymphoma - a multicenter retrospective data analysis with 70 patients.","authors":"Inga Hansen-Abeck, Glenn Geidel, Finn Abeck, Julian Kött, Rohat Cankaya, Gabor Dobos, Christina Mitteldorf, Jan P Nicolay, Jana D Albrecht, Christian Menzer, Elisabeth Livingstone, Miriam Mengoni, Andreas D Braun, Marion Wobser, Claus-Detlev Klemke, Sabine Tratzmiller, Chalid Assaf, Patrick Terheyden, Kai-Christian Klespe, Stefan W Schneider, Nina Booken","doi":"10.1111/ddg.15511","DOIUrl":"10.1111/ddg.15511","url":null,"abstract":"Background: Interferon-alpha is an important therapeutic option for the treatment of the cutaneous T-cell lymphomas (CTCL). Since the approved recombinant interferon-α-2a (IFN-α2a) has no longer been produced since January 2020, pegylated interferon-α2a (pegIFN-α2a) can be used as an alternative treatment, even though it is not approved for the treatment of CTCL. The aim of this multicentre study was to generate comprehensive data on the efficacy and tolerability of pegIFN-α2a in the treatment of CTCL.Patients and methods: A multicenter retrospective study was conducted with 70 patients with CTCL from twelve German skin centers.Results: In total, 70 patients were included in the study, with 57.2% male and a mean age of 58.8 ± 14.9 years. Mycosis fungoides was present in 71.4% of cases and Sézary Syndrome in 28.6%. An overall response rate of 55.2% was observed with pegIFNα-2a therapy. In 50% of cases, therapy was discontinued after 63.6 ± 33.5 weeks. The most common reason for discontinuation was adverse events, which occurred in 68.6% of cases and which were classified as severe in 29.2%. Blood count changes, fatigue and liver toxicity occurred most frequently.Conclusions: Our analysis provides comprehensive data on the efficacy and tolerability of pegIFNα-2a therapy in patients with CTCL. In terms of response rates and side effect profile, pegIFNα-2a appears to be comparable to IFN-α2a therapy.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperkeratotic-encrusted plaques on the legs, arthralgias, and chronic otitis in a 11-year-old girl. 一名 11 岁女孩腿部出现角化过度结痂斑、关节痛和慢性耳炎。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2024-11-01 Epub Date: 2024-08-22 DOI: 10.1111/ddg.15528

Jana Roßner, Wolfgang Hartschuh, Mark Kriegsmann, Jürgen Isele, Felix Herth, Ferdinand Toberer

引用次数: 0