Journal Der Deutschen Dermatologischen Gesellschaft最新文献_第5页

Complete remission of scalp angiosarcoma after combined chemotherapy and anti-PD-1 immunotherapy: A case report. 化疗联合抗pd -1免疫治疗后头皮血管肉瘤完全缓解1例。

IF 5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-09-27 DOI: 10.1111/ddg.70522

Henan Qin, Zhen Ning, Yibin Teng, Ying Lin, Aman Wang, Jiwei Liu

引用次数: 0

Immune effector cell-associated neurotoxicity syndrome (ICANS) during tebentafusp in metastatic uveal melanoma. 免疫效应细胞相关神经毒性综合征（ICANS）在tebentafusp期间转移性葡萄膜黑色素瘤。

IF 5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-09-24 DOI: 10.1111/ddg.70523

Laura Schreieder, Laura Jockel, Veronika Zenderowski, Ralf A Linker, Sebastian Haferkamp, Elisabeth Bumes, Peter Hau, Konstantin Drexler

引用次数: 0

S1 Guideline: Management of ingrown nails (Unguis incarnatus, Onychocryptosis) and pincer nails (Unguis in turriculo). S1指南：内生甲（爪状甲，爪状甲）和钳形甲（爪状甲）的处理。

IF 5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-09-23 DOI: 10.1111/ddg.70442x

Antonia Pennitz, Galina Balakirski, Oliver Gahn-Schuster, Steffen Gass, Anna Giordano-Rosenbaum, Lutz Alexander Graumann, Peter Kalbe, Rainer Kübke, Severin Läuchli, Nicholas Moellhoff, Cornelia S L Müller, Alexander Nast, Tatjana Pfersich, Ralph von Kiedrowski, Miriam Zidane, Christoph R Löser

{"title":"S1 Guideline: Management of ingrown nails (Unguis incarnatus, Onychocryptosis) and pincer nails (Unguis in turriculo).","authors":"Antonia Pennitz, Galina Balakirski, Oliver Gahn-Schuster, Steffen Gass, Anna Giordano-Rosenbaum, Lutz Alexander Graumann, Peter Kalbe, Rainer Kübke, Severin Läuchli, Nicholas Moellhoff, Cornelia S L Müller, Alexander Nast, Tatjana Pfersich, Ralph von Kiedrowski, Miriam Zidane, Christoph R Löser","doi":"10.1111/ddg.70442x","DOIUrl":"https://doi.org/10.1111/ddg.70442x","url":null,"abstract":"The newly developed S1 guideline \"Management of the Ingrown Nail (Unguis incarnatus, Onychocryptosis) and the Pincer Nail (Unguis in turriculo, Pincer-Nail)\" (AWMF Registry Number 013-106) provides, for the first time, structured, practice-oriented recommendations for two common nail disorders that have previously been managed heterogeneously across disciplines. The guideline was developed by a multidisciplinary expert group and is based on the available literature as well as empirical experience in the diagnosis and treatment of ingrown toenails and pincer nails. Its aim is to define diagnostic criteria, preventive measures, and therapeutic approaches. For ingrown nails, the guideline presents definitions, a clinical classification (grades I-III), and corresponding treatment recommendations. Conservative measures, podiatric interventions, and patient-centered prevention are emphasized, while surgical procedures - particularly minimally invasive techniques with partial matrix excision - are recommended for therapy-resistant or severe cases. For pincer nails, definitions, clinical morphology, and potential therapeutic options are described; due to limited data, individualized management is emphasized. The guideline aims to standardize care, reduce treatment variability, and promote a consistent, interdisciplinary approach.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small Lesions, Big Challenge: Why Real-World Denominators Matter for AI-Supported Melanoma Diagnosis. 小病变，大挑战：为什么真实世界的分母对人工智能支持的黑色素瘤诊断很重要。

IF 5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-09-23 DOI: 10.1111/ddg.70702

Vincenzo de Giorgi, Giovanni Cecchi, Virginia Marabini, Ginevra Gurioli, Gabriella Perillo, Federica Fazzari, Biancamaria Zuccaro

引用次数: 0

Evaluation of suspected delayed-type allergy to beta-lactam antibiotics: a 6-year retrospective single center experience. 对β -内酰胺类抗生素可疑迟发性过敏的评估：6年回顾性单中心经验。

IF 5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-09-21 DOI: 10.1111/ddg.70534

Katharina Pietschke, Morna F Schmidt, Gerda Wurpts, Jörg Fischer, Amir S Yazdi

{"title":"Evaluation of suspected delayed-type allergy to beta-lactam antibiotics: a 6-year retrospective single center experience.","authors":"Katharina Pietschke, Morna F Schmidt, Gerda Wurpts, Jörg Fischer, Amir S Yazdi","doi":"10.1111/ddg.70534","DOIUrl":"https://doi.org/10.1111/ddg.70534","url":null,"abstract":"Background and objectives: As allergies against beta-lactam antibiotics (BLA) are among the most common drug allergies, diagnostic testing is essential when an allergic reaction is suspected. To investigate the outcomes of allergy testing in patients with delayed-type allergy to BLA.Patients and methods: The prevalence of delayed-type allergy to aminopenicillins or other BLA as well as their cross-reactivity, were analyzed by using skin testing (patch, prick, intradermal tests) and drug challenge testing (DCT).Results: Aminopenicillins were the most frequently suspected culprit drugs in the evaluated cohort (n = 487), and delayed-type allergy was confirmed in 29.9% of patients. DCT was positive despite negative skin test results in 6.0% (29/487). Cross reactivity with closely related BLA groups were found in 10% (8/80) of patients. Given that 88.9% (297/334) of patients with previous negative skin test results tolerated the subsequent drug challenge without allergic reaction, the negative predictive value of skin testing appears reliable within a standardized clinical setting.Conclusions: Thorough allergy diagnostic testing prevents re-exposure to culprit drugs and enables the delabeling of patients with suspected drug allergy, thereby avoiding unnecessary treatment restrictions. Allergy testing is therefore an important and effective component of the diagnostic workup following a history of maculopapular exanthema.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pruritus and Psychiatric Distress in SLC20A2-Associated PFBC: A Dual-Specialty Perspective. slc20a2相关PFBC的瘙痒和精神困扰：双专业视角

IF 5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-09-16 DOI: 10.1111/ddg.70701

Emerson Lima, Joao Ricardo Mendes Oliveira

引用次数: 0

Transfusion-associated graft-vs-host disease after liver transplantation presenting with rash and pancytopenia. 肝移植后输血相关的移植物抗宿主病，表现为皮疹和全血细胞减少。

IF 5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-09-16 DOI: 10.1111/ddg.70604

Irene Rivera-Ruiz, César Guijarro-Sánchez, Pedro J Gómez-Arias, Rafael Sánchez-Sánchez, Manuel Galán-Gutiérrez, Antonio José Vélez García-Nieto

引用次数: 0

Management of severe psoriasis in a renal transplant recipient with latent tuberculosis using risankizumab. 利桑单抗治疗潜伏结核肾移植受者严重银屑病。

IF 5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-09-16 DOI: 10.1111/ddg.70610

April Lauren R Goundry, Magdi Yaqoob, Aadarsh Shah, Malvina Cunningham, Anthony Bewley, Maria-Angeliki Gkini

引用次数: 0

Navigating Treatments in Folliculitis Decalvans: A Comprehensive Systematic Review. Decalvans毛囊炎的导航治疗：一项全面的系统综述。

IF 5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-09-16 DOI: 10.1111/ddg.70607

Imad Al-Naesan, Thomas Trafoier, Daniela Krepper, Johannes M Giesinger, Florian Regensberger, Simone Cazzaniga, Pierre A de de Viragh, Seyed M Seyed Jafari

{"title":"Navigating Treatments in Folliculitis Decalvans: A Comprehensive Systematic Review.","authors":"Imad Al-Naesan, Thomas Trafoier, Daniela Krepper, Johannes M Giesinger, Florian Regensberger, Simone Cazzaniga, Pierre A de de Viragh, Seyed M Seyed Jafari","doi":"10.1111/ddg.70607","DOIUrl":"https://doi.org/10.1111/ddg.70607","url":null,"abstract":"Folliculitis decalvans (FD) is a chronic neutrophilic cicatricial alopecia characterized by recurrent scalp inflammation, pustules, tufted hairs, and progressive permanent hair loss. Owing to its relapsing course and the absence of standardized treatment guidelines, therapeutic management remains challenging. This systematic review summarizes available treatment approaches and reported outcomes in FD. A systematic literature search of PubMed, Web of Science, Embase, and Cochrane databases was conducted according to PRISMA guidelines and registered in PROSPERO (CRD42023467796). Studies published between 1999 and December 2024 reporting treatment outcomes in at least one patient with FD were included. Full remission was defined as complete absence of inflammatory activity with stable disease, while partial remission indicated clinical improvement without relevant alopecia progression. Overall, 64 studies comprising 300 patients were included, mainly retrospective studies, case series, and case reports with low levels of evidence. Antibiotic-based therapies, particularly rifampicin-clindamycin combinations, showed favorable initial responses but frequent relapse after discontinuation. Isotretinoin demonstrated comparatively durable responses, with remission rates up to 82%. Biologic and targeted immunomodulatory therapies, including TNF-α inhibitors, apremilast, and various JAK inhibitors, showed promising outcomes in refractory cases. Current evidence supports individualized long-term treatment strategies focused on inflammation control and prevention of irreversible scarring.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 1% glycopyrronium bromide cream for topical treatment of severe primary axillary hyperhidrosis in adolescents: safety, local tolerability, systemic exposure and efficacy from an open-label phase II study. 一种用于局部治疗青少年严重原发性腋下多汗症的1%甘溴铵乳膏：来自开放标签II期研究的安全性、局部耐受性、全身暴露和有效性

IF 5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-09-15 DOI: 10.1111/ddg.70469

Rolf-Markus Szeimies, Ana Kilic, Hubert Reich, Birgit Berger, Erik Schulze Zur Wiesche, Leonie Litzka, Katharina Schramm, Susanne Heimstaedt-Muskett, Clarissa Masur

{"title":"A 1% glycopyrronium bromide cream for topical treatment of severe primary axillary hyperhidrosis in adolescents: safety, local tolerability, systemic exposure and efficacy from an open-label phase II study.","authors":"Rolf-Markus Szeimies, Ana Kilic, Hubert Reich, Birgit Berger, Erik Schulze Zur Wiesche, Leonie Litzka, Katharina Schramm, Susanne Heimstaedt-Muskett, Clarissa Masur","doi":"10.1111/ddg.70469","DOIUrl":"10.1111/ddg.70469","url":null,"abstract":"Background and objectives: Primary axillary hyperhidrosis (PAHH) results from dysregulation of the autonomic nervous system and typically begins during puberty. Treatment options for adolescents remain limited. This open-label phase II study evaluated the safety, local tolerability, systemic exposure, and efficacy of 1% GPB cream over 8 weeks in adolescents with severe PAHH.Patients and methods: A total of 42 adolescents (23 male [55%] and 19 female [45%]; aged 12-17 years) applied the cream once daily for the first 4 weeks and thereafter as needed (at least twice weekly but no more than once daily). The primary endpoints assessed adverse drug reactions (ADRs), local tolerability, and systemic glycopyrronium exposure. Changes in sweat production, PAHH severity, and quality of life were assessed in all patients.Results: Two patients experienced mild ADRs (dry eye and increased conjugated bilirubin in one patient each); no serious adverse events occurred. All 40 evaluable patients had a skin reaction score of 0 throughout treatment. Total sweat production decreased significantly from baseline to day 29 (p < 0.001) and day 57 (p < 0.001). Patient-rated hyperhidrosis severity (PRHS) and quality of life, assessed using the Children's Dermatology Life Quality Index (CDLQI), also improved significantly at both time points (all p < 0.001).Conclusions: 1% GPB cream showed favorable safety and tolerability and improved clinical outcomes in adolescents with severe PAHH, consistent with findings in adults.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0