Journal Der Deutschen Dermatologischen Gesellschaft最新文献_第6页

Surgical therapy of recurrent genital cysts. 复发性生殖器囊肿的外科治疗。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-09-14 DOI: 10.1111/ddg.15863

Julia Sipos, Jörg Neymeyer, Veronika Weger, Sylke Schneider-Burrus

引用次数: 0

Multiple grouped brown-red nodules on the lower leg. 下肢多组棕红色结节。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-09-14 DOI: 10.1111/ddg.15954

Xi Tan, Zhouwei Wu

引用次数: 0

Implementing PEN-FAST for penicillin allergy delabeling in a high-prevalence population. 在高流行人群中实施青霉素过敏去除标签的PEN-FAST。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-09-14 DOI: 10.1111/ddg.15862

Deniz Göcebe, Katharina S Kommoss, Martin Hartmann, Alexander H Enk, Knut Schäkel

{"title":"Implementing PEN-FAST for penicillin allergy delabeling in a high-prevalence population.","authors":"Deniz Göcebe, Katharina S Kommoss, Martin Hartmann, Alexander H Enk, Knut Schäkel","doi":"10.1111/ddg.15862","DOIUrl":"https://doi.org/10.1111/ddg.15862","url":null,"abstract":"Background and objectives: Self-reported penicillin allergies lead to the use of broad-spectrum antibiotics, increase drug resistance, and constitute an economic burden. The PEN-FAST score aims to identify low-risk patients for direct drug provocation tests (DPT) without prior skin testing with a reported negative predictive value (NPV) of over 95%.Patients and methods: In this single-center study (Department of Dermatology, University Hospital Heidelberg, Germany), the PEN-FAST score was evaluated for patients carrying a penicillin allergy label between 2004 and 2024. Skin testing, allergen-specific IgE, and consecutive DPT were performed.Results: A total of 189 patients were analyzed. In a retrospective cohort, 106 of 149 patients showed negative skin tests and received DPT, leading to the delabeling of 99 patients (66.4%). PEN-FAST identified 55 of 149 (36.9%) as low-risk, of which three low-risk patients were misclassified. In a prospective PEN-FAST low-risk cohort, one of 40 patients showed a mild reaction after DPT. Overall, NPVs of both PEN-FAST and formal allergy testing were 95.8%.Conclusions: Our results advocate for direct DPT in patients carrying a penicillin allergy label classified as low-risk by PEN-FAST. PEN-FAST demonstrated high NPV, safety, and feasibility in a cohort with a high prevalence of true allergies.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food-dependent exercise-induced anaphylaxis (FDEIA) to maize. 玉米食物依赖性运动诱导过敏反应（FDEIA）。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-09-10 DOI: 10.1111/ddg.15872

Moritz M Hollstein, Katharina K Hahn, Prasad Dasari, Michael P Schön, Timo Buhl

引用次数: 0

Alternating ablative fractional laser and microneedling radiofrequency outperforms ablative fractional laser alone for acne scars. 交替烧蚀分数激光和微针射频优于烧蚀分数激光单独治疗痤疮疤痕。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-09-10 DOI: 10.1111/ddg.15873

Haoyu He, Yuanyuan Qiu, Qiliang Liu

{"title":"Alternating ablative fractional laser and microneedling radiofrequency outperforms ablative fractional laser alone for acne scars.","authors":"Haoyu He, Yuanyuan Qiu, Qiliang Liu","doi":"10.1111/ddg.15873","DOIUrl":"https://doi.org/10.1111/ddg.15873","url":null,"abstract":"Background: Moderate to severe acne scars pose a therapeutic challenge and often require multimodal treatments. Ablative fractional laser (AFL) and fractional microneedling radiofrequency (FMR) are commonly used, but their alternating application has not been fully studied.Patients and methods: In this prospective, randomized, single-blind, split-face trial, 20 patients (Fitzpatrick III-IV) received four treatments at 4-week intervals: one facial side underwent alternating FMR (sessions 1, 3) and AFL (sessions 2, 4), while the contralateral side received AFL alone. Outcomes included Échelle d'Évaluation Clinique des Cicatrices d'Acné (ECCA) scores, sebum secretion, patient satisfaction, and adverse events over 24 weeks.Results: Alternating therapy achieved superior ECCA score reduction (53.5% vs. 41.7%, p < 0.05) and significant sebum reduction (88.6 ± 12.9 to 81.3 ± 19.1 µg/cm2, p < 0.05) compared to AFL alone. Patient satisfaction was higher in the alternating group (85% vs. 70%), despite greater procedural pain (VAS: 5.8 ±1.3 vs. 4.6 ±1.1, p < 0.05). Adverse events (transient erythema, crusting) were comparable between groups.Conclusions: Alternating AFL and FMR is more effective than AFL alone for treating moderate to severe acne scars, offering better outcomes with acceptable safety. Larger studies and extended follow-up are needed.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attack out of the soil at 5,120 ft above sea level: tinea corporis due to Nannizzia fulva. 从海拔5120英尺的土壤中攻击：由南尼齐亚富尔瓦引起的公司癣。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-09-08 DOI: 10.1111/ddg.15871

Veronika Batzill, Marie-Charlotte Brüggen, Matthias Möhrenschlager

引用次数: 0

Status quo and future developments in the diagnosis and treatment of hereditary angioedema. 遗传性血管性水肿的诊断和治疗现状及未来发展。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-09-04 DOI: 10.1111/ddg.15889

Andreas Recke

{"title":"Status quo and future developments in the diagnosis and treatment of hereditary angioedema.","authors":"Andreas Recke","doi":"10.1111/ddg.15889","DOIUrl":"https://doi.org/10.1111/ddg.15889","url":null,"abstract":"Hereditary angioedema (HAE) is a rare hereditary disease characterized by edema, which can be life-threatening in case of swelling in the larynx. The most common form of HAE is caused by a mutation of the SERPING1 gene and is characterized by a deficiency (type I) or loss of function (type II) of the C1 inhibitor (C1-INH), leading to excessive production of bradykinin. In contrast, the HAE-nC1-INH entity is associated with a normal C1-INH protein and is caused by mutations in other genes. Because HAE is a rare and often underdiagnosed disease, it may take years from symptom onset to diagnosis. The angioedema attacks cause suffering and affect both the ability to work and quality of life (QoL). The treatment of HAE includes attack treatment (on-demand), short-term prophylaxis (e.g., before medical procedures), and long-term prophylaxis. Four first-line treatment options for long-term prophylaxis are available, effectively preventing attacks and supporting the guideline goal of complete disease control. Further treatment options, including CRISPR/Cas9-based gene therapy, are under development and promise to provide individually tailored treatment for patients. This review aims to provide an overview of the clinical presentation, diagnosis, and treatment of HAE.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of dermatoscopy and LC-OCT as a diagnostic extension for scabies. 皮镜检查与LC-OCT诊断疥疮的相关性。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-09-04 DOI: 10.1111/ddg.15945

Lukas Kofler, Uzay Cambaz, Maren Heinecke, Garance Hubert, Katrin Kofler

引用次数: 0

Systemic immunomodulating therapies for epidermal necrolysis (Stevens-Johnson syndrome/toxic epidermal necrolysis): A systematic review and meta-analysis. 系统性免疫调节疗法治疗表皮坏死松解（Stevens-Johnson综合征/中毒性表皮坏死松解）：系统综述和荟萃分析。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-09-04 DOI: 10.1111/ddg.15804

Ruben Heuer, Maren Paulmann, Maja Mockenhaupt, Alexander Nast

{"title":"Systemic immunomodulating therapies for epidermal necrolysis (Stevens-Johnson syndrome/toxic epidermal necrolysis): A systematic review and meta-analysis.","authors":"Ruben Heuer, Maren Paulmann, Maja Mockenhaupt, Alexander Nast","doi":"10.1111/ddg.15804","DOIUrl":"https://doi.org/10.1111/ddg.15804","url":null,"abstract":"Background and objectives: Epidermal necrolysis is a rare but severe cutaneous reaction with high mortality. Limited evidence exists regarding the efficacy of systemic immunomodulatory therapies (SITs). Our systematic review aimed to compare SITs with supportive care or one another.Patients and methods: Randomized controlled trials and controlled observational studies (≥ 5 patients of all ages per arm) using the international consensus classification for EN (Bastuji-Garin, 1993) with no significant baseline differences were included. We searched MEDLINE, Embase, and Cochrane CENTRAL (January 1, 1993-January 22, 2024). Two reviewers independently extracted study and outcome data. A random-effects meta-analysis was performed.Results: The main outcome was mortality. Secondary outcomes included hospital stay duration, time to complete reepithelialization, complications, and sequelae. 43 studies with 58 treatment comparisons were analyzed. Cyclosporine was superior to IVIG regarding mortality (RR 0.18, 95% CI 0.05-0.58), and corticosteroids plus IVIG reduced serious complications compared to corticosteroids alone (sepsis, RR 0.77, 95% CI 0.31-0.77). Compared to supportive care, only etanercept showed a significant mortality benefit (RR 0.32, 95% CI 0.11-0.93; GRADE: imprecision/unclear clinical importance).Conclusions: There is no clear evidence of the superiority of SITs over supportive care, which remains the primary treatment for EN.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soluble IL-2 receptor levels support diagnosis of sarcoidosis-like reaction in melanoma patients on immunotherapy - a diagnostic algorithm based on a single center retrospective study. 可溶性IL-2受体水平支持免疫治疗黑色素瘤患者结节样反应的诊断-基于单中心回顾性研究的诊断算法。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-08-31 DOI: 10.1111/ddg.15727

Philipp Gussek, Julia Mentzel, Maxime Ablefoni, Mirjana Ziemer

{"title":"Soluble IL-2 receptor levels support diagnosis of sarcoidosis-like reaction in melanoma patients on immunotherapy - a diagnostic algorithm based on a single center retrospective study.","authors":"Philipp Gussek, Julia Mentzel, Maxime Ablefoni, Mirjana Ziemer","doi":"10.1111/ddg.15727","DOIUrl":"https://doi.org/10.1111/ddg.15727","url":null,"abstract":"Background and objectives: Drug-induced sarcoidosis-like reaction (DISR) is an adverse event with emerging importance during immune checkpoint inhibitor (ICI) treatment in melanoma patients. Its reported frequency varies widely, making accurate diagnosis crucial. Distinguishing DISR from tumor progression is challenging, and misdiagnosis may lead to detrimental treatment changes. Thus, reliable diagnostic markers complementing histopathology as well as a diagnostic algorithm are needed.Patients and methods: This single-center retrospective study, conducted at the University Medical Center in Leipzig, Germany, from 09/2019 to 06/2021, assessed DISR prevalence in melanoma patients treated with ICI for metastatic melanoma. We examined clinical characteristics, radiology, histopathology, and serum parameters.Results: From a total of 177 patients 19 patients were suspicious for DISR. Of those, DISR was diagnosed in seven patients. In a further nine patients DISR was highly probable based on radiological findings and noticeably increased soluble interleukin-2-receptor (sIL2R) levels, resulting in DISR prevalence of 9%. No patient required permanent discontinuation of ICI due to DISR.Conclusions: In melanoma patients receiving ICI, DISR is common. Histological confirmation through mediastinoscopy or pulmonary wedge resection offers the highest diagnostic accuracy. When histology is not available, sIL2R levels can aid diagnosis. We propose an algorithm to distinguish DISR from tumor progression.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0