Alternating ablative fractional laser and microneedling radiofrequency outperforms ablative fractional laser alone for acne scars.

IF 3.8 4区医学 Q1 DERMATOLOGY

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-09-10 DOI:10.1111/ddg.15873

Haoyu He, Yuanyuan Qiu, Qiliang Liu

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引用次数: 0

Abstract

Background: Moderate to severe acne scars pose a therapeutic challenge and often require multimodal treatments. Ablative fractional laser (AFL) and fractional microneedling radiofrequency (FMR) are commonly used, but their alternating application has not been fully studied.

Patients and methods: In this prospective, randomized, single-blind, split-face trial, 20 patients (Fitzpatrick III-IV) received four treatments at 4-week intervals: one facial side underwent alternating FMR (sessions 1, 3) and AFL (sessions 2, 4), while the contralateral side received AFL alone. Outcomes included Échelle d'Évaluation Clinique des Cicatrices d'Acné (ECCA) scores, sebum secretion, patient satisfaction, and adverse events over 24 weeks.

Results: Alternating therapy achieved superior ECCA score reduction (53.5% vs. 41.7%, p < 0.05) and significant sebum reduction (88.6 ± 12.9 to 81.3 ± 19.1 µg/cm², p < 0.05) compared to AFL alone. Patient satisfaction was higher in the alternating group (85% vs. 70%), despite greater procedural pain (VAS: 5.8 ±1.3 vs. 4.6 ±1.1, p < 0.05). Adverse events (transient erythema, crusting) were comparable between groups.

Conclusions: Alternating AFL and FMR is more effective than AFL alone for treating moderate to severe acne scars, offering better outcomes with acceptable safety. Larger studies and extended follow-up are needed.

查看原文本刊更多论文

交替烧蚀分数激光和微针射频优于烧蚀分数激光单独治疗痤疮疤痕。

背景：中度至重度痤疮疤痕的治疗挑战，往往需要多种模式的治疗。烧蚀分数激光（AFL）和分数微针射频（FMR）是常用的两种方法，但它们的交替应用还没有得到充分的研究。患者和方法：在这项前瞻性、随机、单盲、裂脸试验中，20名患者（Fitzpatrick III-IV）每隔4周接受4种治疗：一侧面部交替接受FMR（第1、3期）和AFL（第2、4期），而对侧单独接受AFL。结果包括Échelle d'Évaluation疤痕诊所（ECCA）评分、皮脂分泌、患者满意度和24周内的不良事件。结果：交替治疗取得了较好的ECCA评分降低效果（53.5% vs. 41.7%, p 2, p）。结论：AFL和FMR交替治疗比单纯AFL治疗中重度痤疮疤痕更有效，疗效更好，安全性可接受。需要更大规模的研究和更长期的随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal Der Deutschen Dermatologischen Gesellschaft 医学-皮肤病学

CiteScore

3.50

自引率

25.00%

发文量

406

审稿时长

1 months

期刊介绍： The JDDG publishes scientific papers from a wide range of disciplines, such as dermatovenereology, allergology, phlebology, dermatosurgery, dermatooncology, and dermatohistopathology. Also in JDDG: information on medical training, continuing education, a calendar of events, book reviews and society announcements. Papers can be submitted in German or English language. In the print version, all articles are published in German. In the online version, all key articles are published in English.