Journal Der Deutschen Dermatologischen Gesellschaft最新文献

{"title":"Neonatal erythroderma in a patient with cartilage-hair hypoplasia: Identification of a novel RMRP mutation.","authors":"María López-Pardo Rico, Noelia Moreiras Arias, Cecilia Buján Bonino, Benigno Monteagudo Sánchez, Patricia Pérez Feal, Graciela Gómez Silva, José Manuel Suárez Peñaranda, Igor Vázquez Osorio","doi":"10.1111/ddg.15687","DOIUrl":"https://doi.org/10.1111/ddg.15687","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capnocytophaga canis erysipelas and bacteremia in an immunocompetent patient.","authors":"Gabriela Blanchard, Maël Blanchard, Manon Rosselin, Géraldine Jost, Nadia Liassine, Laurence Toutous-Trellu, David Alvarez Martinez","doi":"10.1111/ddg.15684","DOIUrl":"https://doi.org/10.1111/ddg.15684","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant treatment with immune checkpoint inhibitors in patients with melanoma: A real-life retrospective study.","authors":"Dirk Tomsitz, Petra Zimmermann, Wolfgang G Kunz, Jens Neumann, Birte J Siegmund, Bernhard G Weiss, Teresa Kauke, Wulf Sienel, Lars E French, Frederick Klauschen, Lucie Heinzerling","doi":"10.1111/ddg.15632","DOIUrl":"https://doi.org/10.1111/ddg.15632","url":null,"abstract":"<p><strong>Background: </strong>Neoadjuvant treatment with ipilimumab and nivolumab has shown efficacy in melanoma patients with nodal metastases in clinical trials. Real world data on neoadjuvant therapies is lacking.</p><p><strong>Patients and methods: </strong>This study investigates the effectiveness of neoadjuvant therapy in a real-world setting and included all melanoma patients who received combined anti-CTLA4/PD1 immunotherapy prior to resection. Pathologic and radiologic responses as well as treatment-related adverse events were assessed, and recurrence-free survival (RFS) was compared between patients with major pathologic response (mPR) and patients without mPR.</p><p><strong>Results: </strong>In total, 24 patients were analyzed, including patients with distant metastases and patients with prior adjuvant treatment. Median follow-up was 21.5 months. Upon histologic assessment, mPR was achieved in 50% (12/24) of the patients, including two patients with lung metastases and three patients who progressed after prior adjuvant anti-PD1 therapy. Radiologic response after neoadjuvant treatment correlated with mPR. No patient with mPR relapsed during follow-up (median RFS not reached) compared to six out of 12 patients without mPR (median RFS = 13 months, p = 0.005).</p><p><strong>Conclusions: </strong>Neoadjuvant treatment with ipilimumab and nivolumab is effective in real-world patients with different melanoma subtypes, different stages of disease and even advanced primary tumor.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematics, diagnosis and treatment of wound infections in chronic wounds: A position paper from WundDACH.","authors":"Joachim Dissemond, Julian-Dario Rembe, Bernd Assenheimer, Marjam Barysch-Bonderer, Veronika Gerber, Jan Kottner, Peter Kurz, Martin Motzkus, Eva-Maria Panfil, Sebastian Probst, Robert Strohal, Jürg Traber, Andreas Schwarzkopf","doi":"10.1111/ddg.15649","DOIUrl":"https://doi.org/10.1111/ddg.15649","url":null,"abstract":"<p><p>Wound infections are still an interdisciplinary and interprofessional challenge, because of numerous complications, particularly in people with chronic wounds. There are many different concepts and approaches in this field today. Therefore, WundDACH, the umbrella organization of the German-speaking wound healing societies, wrote a position paper on this important topic. An interdisciplinary and interprofessional group of experts from German-speaking countries developed definitions and procedures for nomenclature, diagnosis and treatment of wound infections in people with chronic wounds in a modified Delphi process. The importance of correctly diagnosing wound infections is emphasized so that adequate treatment can be carried out as early and specifically as possible. For a differentiated assessment, a simplified continuum of wound infection with contamination, colonization, local and systemic infection and the corresponding therapeutic consequences was described. Most bacteria in wounds can be removed by repeated wound-irrigation and debridement. Local wound infections are diagnosed based on clinical signs of infection and TILI score. Treatment is then usually exclusively local, for example with modern antiseptics such as polyhexanide. Systemic antibiotics should mostly be considered when signs of systemic infections appear. The indication for antimicrobial wound therapy should be critically reviewed after 10-14 days at the latest.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous-limited, initially strongly unilateral microscopic polyangiitis.","authors":"Roman Saternus, Thomas Vogt, Zanir Abdi","doi":"10.1111/ddg.15675","DOIUrl":"https://doi.org/10.1111/ddg.15675","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age is not an obstacle: Tumor excisions under local anesthesia even in very old people.","authors":"Angelika Ries, Edgar Dippel, Christoph R Löser","doi":"10.1111/ddg.15689","DOIUrl":"https://doi.org/10.1111/ddg.15689","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiological insights into the successful treatment of EBV-positive hydroa vacciniforme lymphoproliferative disorder with hydroxychloroquine.","authors":"Christina Bürgler, Lukas Meyer-Landolt, Stefanie Häfliger, Roland Blum, Antonia Reimer-Taschenbrecker, Luca Borradori, Ronald Wolf","doi":"10.1111/ddg.15683","DOIUrl":"https://doi.org/10.1111/ddg.15683","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing small wounds in aesthetically relevant regions - \"delayed suturing\" revisited.","authors":"Jonas K Krekel, Delaram Pockrandt-Tahmasian, Edgar Dippel, Christoph R Löser","doi":"10.1111/ddg.15661","DOIUrl":"https://doi.org/10.1111/ddg.15661","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gingival biopsy - enoral technique for Dermatology.","authors":"Stefanie Lischker, Edgar Dippel, Christoph R Löser","doi":"10.1111/ddg.15694","DOIUrl":"https://doi.org/10.1111/ddg.15694","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The discrepancy between managing the disease and a disease management program in systemic melanoma therapy","authors":"Matthias Brandlmaier,&nbsp;Peter Koelblinger","doi":"10.1111/ddg.15645","DOIUrl":"10.1111/ddg.15645","url":null,"abstract":"&lt;p&gt;Dear Editors,&lt;/p&gt;&lt;p&gt;Given the improved survival of patients with advanced melanoma, especially after immune checkpoint inhibitor (ICI) therapy, long-term follow-up is critical to monitor and treat chronic immune-related adverse events (irAE). However, despite existing guidelines providing distinct recommendations, there may be hurdles to implementation in everyday clinical practice.&lt;span&gt;&lt;sup&gt;1, 2&lt;/sup&gt;&lt;/span&gt; In internal medicine, disease management programs (DMP) pursue and successfully implement holistic therapeutic concepts, whereby this collaborative approach has reduced rehospitalizations and deaths, lowered healthcare costs, and improved patient responsibility through better interdisciplinary networking.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Training for all cancer team members across specialist boundaries is essential for effective collaboration and optimizing patient outcomes.&lt;/p&gt;&lt;p&gt;In order to evaluate the need for (unmet) accompanying support (psychological, physiotherapeutic, social), we conducted a questionnaire-based analysis at our dermato-oncology center. A total of 72 questionnaires were completed. These included 14 questions regarding melanoma stage, treatment, associated events such as irAE or unplanned hospital stays due to acute deterioration of health status and the demand for additional services like physiotherapy or psychological counseling. Approximately 75% of patients received dermato-oncological care for up to 2 years, a quarter for more than 3 years. Common prior conditions included cardiac (43%), ophthalmological (26.4%) and joint disorders (20.8%). Immune checkpoint inhibitor therapy was the most common melanoma-specific treatment, administered in 82% of patients, followed by targeted therapy in 29%. Fourteen patients (19.4%) received both. Over half of all patients reported treatment-associated fatigue, followed by other commonly described irAE of systemic melanoma therapy (Table 1).&lt;/p&gt;&lt;p&gt;In case of irAE, patients most frequently turned to the dermato-oncology clinic first (48.6%), followed by general practitioners (11.1%) and dermatologists in private practice (8.3%). More than half of all patients required additional medical support during treatment, including 19 hospital admissions (26%) within the last 6 months before completion of the questionnaire. Patient satisfaction with outpatient dermato-oncological care was high: organization, accessibility, appointment coordination, and time management were rated as good or excellent by more than 80%. However, there was room for improvement regarding appointment coordination and time management in outpatient dermato-oncological care: around 10% of patients rated these services as only average and less than 1% as poor. Physiotherapy (51.4%), nutritional medicine (45.8%), melanoma education (18.1%) and psychotherapy (15%) were most frequently requested. Three key priorities from the patients’ perspective were interdisciplinary cooperation (59.7%), availability of additional care ","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 4","pages":"527-531"},"PeriodicalIF":5.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}