Journal Der Deutschen Dermatologischen Gesellschaft最新文献_第4页

Optical coherence tomography for assessing port-wine stains: a systematic review. 光学相干断层扫描评估葡萄酒色斑：系统回顾。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-06-04 DOI: 10.1111/ddg.15813

Marina Mordehachvili Burlá, Fabíola Leal Silva, Beatriz Ximenes Mendes, Lilia Maria Lima de Oliveira, Maria Tsoukas, Roger Haber

引用次数: 0

Baricitinib in the treatment of eosinophilic pustular folliculitis resistant to indomethacin. 巴西替尼治疗耐吲哚美辛的嗜酸性脓疱性毛囊炎。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-06-04 DOI: 10.1111/ddg.15774

Yan Liu, Mengmeng Liu, Shengli Chen, Yongxia Liu, Guizhi Zhou, Guoyan Liu

引用次数: 0

Oral lichen planus in a patient treated with anti-CD20 monoclonal antibodies. 用抗cd20单克隆抗体治疗口腔扁平苔藓1例。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-06-04 DOI: 10.1111/ddg.15777

Willy Chan, Alexander Nast, Gabriela Poch, Kamran Ghoreschi

引用次数: 0

Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma initially demonstrating near-complete metabolic response to BV-CHEP. 原发性皮肤cd8阳性侵袭性表皮细胞毒性t细胞淋巴瘤最初对BV-CHEP表现出近乎完全的代谢反应。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-05-30 DOI: 10.1111/ddg.15788

Tristen Tze Wei Ng, Aaron James Frederiks, Jean-Frank Iacobelli, Hun Sheng Chuah, Dejan Radeski, Thomas Anthony Delaney

引用次数: 0

How to treat primary cutaneous B cell lymphoma - Results from a monocentric cohort study on 98 patients. 如何治疗原发性皮肤B细胞淋巴瘤-来自98例患者的单中心队列研究的结果。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-05-30 DOI: 10.1111/ddg.15702

Rohat Cankaya, Pit Leonard Kleiner, Franz Joachim Hilke, Rose Moritz, Thomas Eigentler, Max Schlaak, Gabor Dobos

{"title":"How to treat primary cutaneous B cell lymphoma - Results from a monocentric cohort study on 98 patients.","authors":"Rohat Cankaya, Pit Leonard Kleiner, Franz Joachim Hilke, Rose Moritz, Thomas Eigentler, Max Schlaak, Gabor Dobos","doi":"10.1111/ddg.15702","DOIUrl":"https://doi.org/10.1111/ddg.15702","url":null,"abstract":"Background: Primary cutaneous B cell lymphomas (CBCL) are chronic diseases with frequent relapses. Time to next treatment (TTNT) is an endpoint reflecting clinical benefit of treatments including patient perspectives. The objectives were to evaluate clinical characteristics, survival, prognosis and TTNT in CBCL.Patients and methods: In this monocentric study, clinical data were extracted between 1998 and 2022. TTNT were calculated. Univariate and multivariate analyses were conducted.Results: Altogether, 46 patients with follicle center lymphoma (pcFCL), 41 with marginal zone lymphoproliferative disorder (pcMZLPD) and 11 with diffuse large B-cell lymphoma, leg type (DLBCL-LT) were identified. 26% of pcFCL patients relapsed frequently. The 5-year relapse-free survival was 71%, 87% and 23% in pcFCL, pcMZLPD and DLBCL-LT, respectively. In pcFCL and pcMZLPD, skin-directed treatments, such as excision or intralesional triamcinolone, performed best based on TTNT, while chemotherapy achieved a mean TTNT of 38 months in DLBCL-LT. In multivariate analysis of all patients, leg involvement was significantly associated with a decreased TTNT of the first treatment, while comorbidities were associated with an increased TTNT.Conclusions: DLBCL-LT had the worst survival. Skin-directed treatments tend to achieve higher TTNT in pcFCL and pcMZLPD, while systemic treatments had higher TTNT in DLBCL-LT.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel and recurrent histopathologic patterns of mogamulizumab-associated rash: diagnostic implications and insights for accurate diagnosis. 莫加单抗相关皮疹的新型和复发性组织病理学模式：诊断意义和准确诊断的见解。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-05-27 DOI: 10.1111/ddg.15773

Christina Mitteldorf

{"title":"Novel and recurrent histopathologic patterns of mogamulizumab-associated rash: diagnostic implications and insights for accurate diagnosis.","authors":"Christina Mitteldorf","doi":"10.1111/ddg.15773","DOIUrl":"https://doi.org/10.1111/ddg.15773","url":null,"abstract":"Background: Mogamulizumab-associated rash (MAR) is a frequent side-effect of a treatment with Mogamulizumab that poses diagnostic challenges.Patients and methods: We reviewed our database for novel histological patterns in MAR.Results: Four new histological patterns were identified: (1) A pagetoid pattern, which could be mistaken for CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma. (2) A lupus erythematosus-like pattern, characterized vacuolar interface dermatitis, deep perivascular lymphocytic infiltrate, interstitial mucin deposits, and clusters of CD123+ plasmacytoid dendritic cells. (3) Pustular folliculitis/acneiform pattern, which may clinically and histologically resemble acne. (4) A combined pattern with MAR coexisting with residual or new infiltrates of the original/underlying lymphoma. Previously described main patterns were reproducible. The folliculotropic and MF-like epidermotropic infiltrate should be also mentioned as separate patterns. Immunohistochemistry and the comparison with the original lymphoma remain crucial for diagnosis, especially a shift towards CD8+ cells, CD7 expression by infiltrating lymphocytes, and an increased number of histiocytes across all MAR patterns.Conclusions: MAR presents a range of histological patterns that mimic other conditions, underscoring the importance of careful histopathological and immunohistochemical analysis and clinicopathological correlation for accurate diagnosis and management.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BAPoma, a rare nevus, as the key to a diagnosis of BAP1-associated tumor predisposition syndrome. bap1，一种罕见的痣，作为诊断bap1相关肿瘤易感性综合征的关键。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-05-27 DOI: 10.1111/ddg.15791

Lara Racz, Sandra Pasternack-Ziach, Isabel Spier, Stephan Forchhammer, Claudia Rehkämper, Peter Kind, Julia Reifenberger, Silke Redler

引用次数: 0

Pyoderma gangrenosum and spider bites: a case series. 坏疽脓皮病和蜘蛛咬伤：一个病例系列。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-05-26 DOI: 10.1111/ddg.15731

Luca Rapparini, Michelangelo La Placa, Giorgio De Benedetto, Yuri Merli, Annalucia Virdi, Cosimo Misciali, Federico Bardazzi

引用次数: 0

Solitary nodular lesion with peripheral arborizing vessels on the back of a 52-year-old male. 52岁男性背部单发结节性病变伴周围树突状血管。

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-05-23 DOI: 10.1111/ddg.15724

Ane Carrera-Gabilondo, Inés Oteiza-Rius, Elisa María Gómez-González, Deiane Marcos-Muñagorri, José Ignacio Echeveste, Rafael Salido-Vallejo

引用次数: 0

Cetuximab plus 5-fluorouracil in patients with advanced cutaneous squamous cell carcinoma: a retrospective cohort study. 西妥昔单抗联合5-氟尿嘧啶治疗晚期皮肤鳞状细胞癌：一项回顾性队列研究

IF 5.5 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2025-05-23 DOI: 10.1111/ddg.15695

Julia Huynh, Thomas Eigentler, Rose K C Moritz, Gabriela Poch, Max Schlaak, Gabor Dobos

{"title":"Cetuximab plus 5-fluorouracil in patients with advanced cutaneous squamous cell carcinoma: a retrospective cohort study.","authors":"Julia Huynh, Thomas Eigentler, Rose K C Moritz, Gabriela Poch, Max Schlaak, Gabor Dobos","doi":"10.1111/ddg.15695","DOIUrl":"https://doi.org/10.1111/ddg.15695","url":null,"abstract":"Background: For patients with locally advanced (la) or metastatic (m) cutaneous squamous cell carcinoma (cSCC) who are not candidates for curative surgery/radiation or systemic anti-PD1 therapy, anti-EGFR in combination with chemotherapy is a rational treatment option.Patients and methods: We analyzed data from 20 patients with cSCC in this monocentric, retrospective study. 4/20 patients had laSCC and 16/20 patients had mSCC. Patients received combined cetuximab and 5-FU between 2015 and 2023. Nine patients received cetuximab + 5-FU as second-line therapy (8 patients after anti-PD-1, 1 patient after radiochemotherapy).Results: One patient had partial response (PR) and 9/20 (45.0%) had stable disease (SD). Disease control rate (PR + SD) was 50%. No complete remissions were observed. One of the non-responders suffered from laSCC, nine patients had mSCC with distant metastases (including parotid) and locoregional lymph node metastases. Treatment was well tolerated, with a median PFS of 3 months (95% confidence interval [CI] 2 months to not assessable [NA]) and median overall survival (OS) of 29 months (95% CI 11-NA). The most common adverse event was acne-like rash in 40.0% of patients.Conclusions: For patients with advanced cSCC who are contraindicated to or have progressed on first-line cemiplimab, combination of cetuximab and 5-FU is a well-tolerated but limited treatment option.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0