Journal Der Deutschen Dermatologischen Gesellschaft最新文献

{"title":"Erfolgreiche Hydroxychloroquin-Behandlung und pathophysiologische Einblicke bei EBV-positiver Hydroa vacciniforme-artiger lymphoproliferativer Erkrankung","authors":"Christina Bürgler, Lukas Meyer-Landolt, Stefanie Häfliger, Roland Blum, Antonia Reimer-Taschenbrecker, Luca Borradori, Ronald Wolf","doi":"10.1111/ddg.15683_g","DOIUrl":"https://doi.org/10.1111/ddg.15683_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 6","pages":"752-754"},"PeriodicalIF":5.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatale Erythrodermie bei einem Patienten mit Knorpel-Haar-Hypoplasie: Identifizierung einer neuen RMRP-Mutation","authors":"María López-Pardo Rico, Noelia Moreiras Arias, Cecilia Buján Bonino, Benigno Monteagudo Sánchez, Patricia Pérez Feal, Graciela Gómez Silva, José Manuel Suárez Peñaranda, Igor Vázquez Osorio","doi":"10.1111/ddg.15687_g","DOIUrl":"https://doi.org/10.1111/ddg.15687_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 6","pages":"755-758"},"PeriodicalIF":5.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal-Club","authors":"Prof. Dr. Rudolf A. Rupec Zürich","doi":"10.1111/ddg.15802_g","DOIUrl":"https://doi.org/10.1111/ddg.15802_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 6","pages":"781-782"},"PeriodicalIF":5.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gelbliche Papeln an der Ohrmuschel eines Kindes","authors":"Eduardo Rozas-Muñoz, Joan Mir-Bonafé, Jaime Piquero-Casals, Rodrigo Araya-Rojas, Juan Andrés Madariaga","doi":"10.1111/ddg.15713_g","DOIUrl":"https://doi.org/10.1111/ddg.15713_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 6","pages":"774-776"},"PeriodicalIF":5.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kombinierte LED-Bestrahlung und photodynamische Tageslichttherapie zur Behandlung aktinischer Keratosen bei Empfängern solider Organtransplantate: eine prospektive, randomisierte, vergleichende und intraindividuelle Studie","authors":"Inés Oteiza-Rius, Ana Morelló-Vicente, Leyre Aguado-Gil, Elisa María Gómez-González, Deiane Marcos-Muñagorri, Ane Carrera-Gabilondo, Rafael Salido-Vallejo","doi":"10.1111/ddg.15665_g","DOIUrl":"https://doi.org/10.1111/ddg.15665_g","url":null,"abstract":"<p>Aktinische Keratosen (AKs) sind präkanzeröse Hautläsionen, die durch längere Exposition gegenüber ultravioletter Strahlung (UV) verursacht werden. Klinisch zeigen sie sich als raue, hyperkeratotische, braun-rote Papeln, die primär sonnenexponierte Areale wie das Gesicht und die Kopfhaut betreffen. AKs gelten als sich entwickelnde Läsionen, da sie sich entweder zurückbilden, persistieren, wiederkehren oder in ein invasives Plattenepithelkarzinom (<i>squamous cell carcinoma</i>, SCC) übergehen können. Während die jährliche Progressionsrate der AK zum SCC bei immunkompetenten Personen relativ gering ist und zwischen 0% und 0,075% pro Läsion beträgt, steigt dieses Risiko bei immunsupprimierten Patienten, insbesondere bei Empfängern solider Organtransplantate (<i>solid organ transplant recipients</i>, SOTRs) signifikant an, vor allem, wenn sie zahlreiche AKs oder klinische Anzeichen chronischer UV-induzierter Hautschäden aufweisen.<span><sup>1, 2</sup></span> SOTRs mit AKs haben ein 32-mal höheres Risiko, ein SCC zu entwickeln, das tendenziell aggressiver ist, mit 5- bis 10-mal höherer Wahrscheinlichkeit von Metastasen und erhöhtem Mortalitätsrisiko. Daher ist frühzeitiges Eingreifen unerlässlich, um die Entwicklung der AKs zu SCC zu verhindern.<span><sup>3</sup></span> Zu diesem Zweck gibt es verschiedene topische Behandlungen, wie die photodynamische Therapie (PDT), 5-Fluorouracil und die Kryotherapie. Die konventionelle PDT (<i>conventional photodynamic therapy</i>, cPDT) ist eine gut etablierte Behandlung bei AKs, die hohe Wirksamkeit und Sicherheit gezeigt hat.<span><sup>4</sup></span> Bei diesem Verfahren wird ein Photosensibilisator – 5-Aminolävulinsäure oder Methylaminolävulinat (MAL) – auf den betroffenen Bereich aufgetragen und anschließend Licht mit Wellenlängen zwischen 404 nm und 420 nm (blaues Licht) oder 635 nm (rotes Licht) ausgesetzt. Diese Aktivierung führt zur Produktion reaktiver Sauerstoffspezies sowie zu anderen indirekten inflammatorischen und immunologischen Prozessen, die zum Absterben von Tumor- und Präkanzerosezellen führen.<span><sup>5</sup></span> Während sich die meisten Studien auf immunkompetente Patienten konzentrierten, bestätigte eine kürzlich durchgeführte Metaanalyse auch bei Transplantatempfängern die Wirksamkeit des Verfahrens bei der Prävention und Behandlung der AK.<span><sup>6</sup></span> Ein bemerkenswerter Nachteil der cPDT sind jedoch die erheblichen Schmerzen, die während und nach der Therapie auftreten, insbesondere bei Transplantationspatienten, die häufig eine höhere Zahl von AKs aufweisen als immunkompetente Personen.<span><sup>7</sup></span> Da die PDT eine der wirksamsten Behandlungen der AK ist, wurden insbesondere bei immunkompetenten Patienten alternative Ansätze erforscht, die die Beschwerden verringern, wie die Tageslicht-PDT (dPDT).<span><sup>8</sup></span> Die dPDT bietet nicht nur eine Feldbehandlung, sondern verbessert auch den Patientenkomfort durch die Schmerzreduktion.</p><p>Zahlreich","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 6","pages":"713-720"},"PeriodicalIF":5.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15665_g","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erysipel und Bakteriämie durch Capnocytophaga canis bei einer immunkompetenten Patientin","authors":"Gabriela Blanchard, Maël Blanchard, Manon Rosselin, Géraldine Jost, Nadia Liassine, Laurence Toutous-Trellu, David Alvarez Martinez","doi":"10.1111/ddg.15684_g","DOIUrl":"https://doi.org/10.1111/ddg.15684_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 6","pages":"749-751"},"PeriodicalIF":5.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: Physician perspectives.","authors":"Manuel P Pereira, Katarina Stevanovic, Emek Kocatürk, Cathrin Meesch, Ingrid van Hofman, Prema S Vaswani, Jonathan A Bernstein, Dayanne Bruscky, Herberto J Chong-Neto, Chia-Yu Chu, Roberta Fachini Jardim Criado, Luis Felipe Ensina, Ana M Giménez-Arnau, Kiran Godse, Maia Gotua, Stamatios Gregoriou, Kanokvalai Kulthanan, Charlotte G Mortz, Natasa Teovska Mitrevska, Esen Özkaya, Prajwal Pudasaini, Mara Morelo Rocha Felix, Catalina Rincón Pérez, Claudio Alberto Salvador Parisi, Gonzalo N Ramón, Efstratios Vakirlis, Zuotao Zhao, Lisa A Beck, Marjolein de Bruin-Weller, Michael Cork, Norito Katoh, Thomas Werfel, Margitta Worm, Andreas Wollenberg, Torsten Zuberbier","doi":"10.1111/ddg.15728","DOIUrl":"https://doi.org/10.1111/ddg.15728","url":null,"abstract":"<p><strong>Background and objectives: </strong>Systemic treatment of pregnant/breastfeeding atopic dermatitis (AD) patients is challenging due to limited safety data. We explored treatment practices with systemic agents, including the guideline-recommended cyclosporine as the first systemic choice as well as emerging therapies, in this vulnerable population.</p><p><strong>Patients and methods: </strong>The Global Allergy and Asthma Excellence Network (GA²LEN) ADCARE initiative collected data from physicians worldwide who treat pregnant women with AD. Physicians completed an electronic questionnaire on the use of systemic agents in pregnant/breastfeeding AD patients.</p><p><strong>Results: </strong>103 physicians from 32 countries completed the survey, primarily dermatologists (n = 48) or allergologists (n = 43). Antihistamines were the systemic drug most often considered to be used during pregnancy/breastfeeding (n = 73/81, 90.1%), with fewer physicians considering the use of systemic agents for the first trimester compared to later stages of pregnancy. For acute flares, systemic corticosteroids (n = 34/80, 42.5%) were preferred, followed by biologics and antihistamines (each n = 15/80, 18.8%). Although the guideline-recommended cyclosporine is sometimes considered for AD during pregnancy (n = 38/81, 46.9%), it was rarely considered as the preferred drug by physicians (n = 1/80, 1.25%).</p><p><strong>Conclusions: </strong>Our study shows a misalignment between guideline recommendations and prescription patterns and highlights an unmet need for knowing and using the existing recommendations.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of routine care of prurigo nodularis in Germany: retrospective chart review study (ADVANCE PN).","authors":"Ralph von Kiedrowski, Martin Metz, Elke Weisshaar, Inka Albrecht, Marie Schild, Sonja Ständer","doi":"10.1111/ddg.15721","DOIUrl":"https://doi.org/10.1111/ddg.15721","url":null,"abstract":"<p><strong>Background and objectives: </strong>Knowledge on patient care gaps of prurigo nodularis (PN) is limited. This retrospective chart review (ADVANCE PN) investigated unmet medical needs and gaps in diagnostics, treatment, and management of patients with PN in routine care in Germany.</p><p><strong>Patients and methods: </strong>Medical records for adults newly diagnosed with PN between January 2012 and December 2022 from dermatologic clinics and office-based dermatologists were analyzed. Baseline demographics, treatment patterns, diagnostics, symptoms, patient-reported outcomes (PROs), and disease-specific scores are reported.</p><p><strong>Results: </strong>Records of 363 patients from 42 sites were analyzed. Median age (range) was 67 (19-95) years; most patients were female (61.7%), Caucasian (73.4%), and retired (57.3%). Overall, 209 (62.2%) patients had comorbidities (most common: hypertension [28.3%]). Clinically, most patients had nodules (81.1%) or papules (66.7%). PROs, disease-specific scores, and laboratory assessments were performed for 32 (8.8%), 12 (3.3%), and 71 (19.7%) patients, respectively. Topical corticosteroids (TCS) were the most common overall (90.9%) and first-line therapy (84.9%); for second-line therapy, 'no further treatment' was most commonly documented (58.6%).</p><p><strong>Conclusions: </strong>The findings of ADVANCE PN indicate a high unmet need in the current state of medical care, evidenced by shortcomings in PRO assessment, PN documentation, and adherence to guidelines on PN.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel variant of the NCSTN gene identified in a woman with hidradenitis suppurativa.","authors":"Conrad Hempel, Sonja Grunewald, Till Mittank-Weidner, Jan-Christoph Simon, Franziska Schnabel, Robin-Tobias Jauss, Viktor Schnabel","doi":"10.1111/ddg.15792","DOIUrl":"https://doi.org/10.1111/ddg.15792","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography for assessing port-wine stains: a systematic review.","authors":"Marina Mordehachvili Burlá, Fabíola Leal Silva, Beatriz Ximenes Mendes, Lilia Maria Lima de Oliveira, Maria Tsoukas, Roger Haber","doi":"10.1111/ddg.15813","DOIUrl":"https://doi.org/10.1111/ddg.15813","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}