Journal Der Deutschen Dermatologischen Gesellschaft最新文献_第3页

Deciphering atopic dermatitis heterogeneity: a short review on the translational revolution from endotypes to immunotypes. 解读特应性皮炎的异质性：从内源性到免疫型的转化革命的简短回顾。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-05-01 Epub Date: 2025-12-13 DOI: 10.1111/ddg.15991

Alvaro Prados-Carmona, Husein Husein-ElAhmed, Francisco J Navarro-Triviño, Ricardo Ruiz-Villaverde

{"title":"Deciphering atopic dermatitis heterogeneity: a short review on the translational revolution from endotypes to immunotypes.","authors":"Alvaro Prados-Carmona, Husein Husein-ElAhmed, Francisco J Navarro-Triviño, Ricardo Ruiz-Villaverde","doi":"10.1111/ddg.15991","DOIUrl":"10.1111/ddg.15991","url":null,"abstract":"Atopic dermatitis is the most prevalent chronic inflammatory skin disease, classically defined by its eczematous lesions and relapsing course. However, growing evidence over the past decade has revealed that this disease is in fact far more heterogeneous than previously thought - both in its clinical manifestations and in the underlying molecular and immunological mechanisms. This short review explores the evolving conceptual framework used to analyze atopic dermatitis, encompassing clinical presentations (phenotypes), immune polarization profiles (immunotypes), and the background disease-related and context-related factors that shape them. The aim of this review is to highlight how such heterogeneity influences disease severity, progression, and therapeutic response, particularly in the context of increasingly personalized treatment strategies. By synthesizing accumulated scientific and clinical insights, this short review provides clinicians with a practical guide to navigating the complex spectrum of AD and its underlying therapeutic targets. Recognizing and interpreting this multidimensional variability is essential for understanding disease course and optimizing treatment selection.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":"602-606"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heuristics, biases, and cognitive pitfalls of emergency teledermatology: Navigating the fine line between making and avoiding diagnostic errors. 急诊远程皮肤科的启发式、偏见和认知陷阱：在制造和避免诊断错误之间的微妙界限中导航。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-05-01 Epub Date: 2025-12-09 DOI: 10.1111/ddg.16003

Charbel Skayem, Tu-Anh Duong

引用次数: 0

One-stage reconstruction of large upper lip oncologic defects using vermilion border rotation-advancement flap. 朱砂缘旋转推进皮瓣一期重建上唇大面积肿瘤缺损。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-05-01 Epub Date: 2025-10-20 DOI: 10.1111/ddg.15938

Zhen-Zhen Zhang, Chao Lian, Ai-Shu Li, Meng-Yao Dang, Xuan-Fen Zhang, Yong-Hong Qin

引用次数: 0

A large erythematous plaque of the scalp. 头皮上的红斑斑块

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-05-01 Epub Date: 2026-02-02 DOI: 10.1111/ddg.16007

Tullio Brunetti, Costantino Ricci, Federico Bardazzi, Michelangelo Fiorentino, Michelangelo La Placa

引用次数: 0

Wells syndrome: clinical findings and treatment management in a large cohort of 48 patients. 威尔斯综合征：48例患者的临床表现和治疗。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-05-01 Epub Date: 2026-01-13 DOI: 10.1111/ddg.15930

Marco Adriano Chessa, Silvia Robuffo, Tullio Brunetti, Luca Rapparini, Bianca Maria Piraccini, Cosimo Misciali, Beatrice Raone, Iria Neri, Federica Filippi

{"title":"Wells syndrome: clinical findings and treatment management in a large cohort of 48 patients.","authors":"Marco Adriano Chessa, Silvia Robuffo, Tullio Brunetti, Luca Rapparini, Bianca Maria Piraccini, Cosimo Misciali, Beatrice Raone, Iria Neri, Federica Filippi","doi":"10.1111/ddg.15930","DOIUrl":"10.1111/ddg.15930","url":null,"abstract":"Background and objectives: Wells syndrome (WS) is a rare inflammatory skin disorder typically characterized by erythematous, edematous, and pruritic plaques. Despite its distinct histopathological features, WS remains an underdiagnosed disease due to its variable clinical presentations and overlap with other dermatological conditions. This study aims to provide a comprehensive overview of WS to enhance diagnostic and management.Patients and methods: A retrospective analysis for the period 2018-2023 was conducted on 48 patients with WS at the Dermatology Unit of the University of Bologna, Italy. Data collected included demographics, clinical manifestations, hematological findings, histopathological characteristics, therapies, and outcomes. Descriptive statistics were used to analyze and summarize the data.Results: The mean onset age was 60.7 years, with 56% of patients having localized WS and 44% generalized WS. The most common subtype was urticaria-like WS (38%), followed by papulonodular, vesiculobullous, granuloma annulare-like, and cellulitis-like forms. First-line treatments included topical and systemic corticosteroids. In contrast, recurrence was observed in 29% of cases during the follow-up.Conclusions: WS is a heterogeneous underdiagnosed condition requiring clinical-histologic correlation for accurate diagnosis. Tailored therapeutic strategies are essential, particularly for generalized or refractory cases. Future research should explore the immunological mechanisms underlying WS and identify predictive factors for recurrence.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":"644-656"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Widespread non-blanching eruption in a female patient with recent fever on immunosuppressive therapy. 一位接受免疫抑制治疗的近期发热的女性患者出现广泛的非漂白性皮疹。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-05-01 Epub Date: 2026-02-07 DOI: 10.1111/ddg.16005

Luca Busana, Stephano Cedirian, Tullio Brunetti, Cosimo Misciali, Bianca Maria Piraccini, Alessandro Pileri

引用次数: 0

Cutaneous non-tuberculous mycobacterial infections: A retrospective study of 94 cases from Germany. 皮肤非结核性分枝杆菌感染：94例德国病例的回顾性研究。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-05-01 Epub Date: 2025-10-14 DOI: 10.1111/ddg.15910

Luisa Bopp, Nicolai Deresz, Henning Klapproth, Isabelle Suárez, Jonathan Jantsch, Mario Fabri, Esther von Stebut

{"title":"Cutaneous non-tuberculous mycobacterial infections: A retrospective study of 94 cases from Germany.","authors":"Luisa Bopp, Nicolai Deresz, Henning Klapproth, Isabelle Suárez, Jonathan Jantsch, Mario Fabri, Esther von Stebut","doi":"10.1111/ddg.15910","DOIUrl":"10.1111/ddg.15910","url":null,"abstract":"Background: Cutaneous non-tuberculous mycobacterial infections (NTM) remain a diagnostic and therapeutic challenge. The aim of this study was to characterize cutaneous NTM infections in Germany over a 24-year-period.Patients and methods: 73 patients with cutaneous NTM infections diagnosed at 17 different German University Hospitals from 2000-2011 and 21 patients treated at the Department of Dermatology of the University Hospital Cologne, from 2010-2024. Retrospective analysis of patient, demographic, clinical information, and data on different diagnostic workups and therapeutic approaches/responses.Results: Together, 94 cases were analyzed (71% males, mean age 50, > 75% immunocompetent). Exposure to fish tanks was the dominant risk factor. Pathogen detection by nucleic acid amplification test and/or culture was successful in 76%. The most common pathogen was Mycobacterium (M.) marinum (> 65%), followed by M. abscessus/chelonae. Immunosuppression was associated with NTM other than M. marinum. Over 90% were treated with oral antibiotics, in more than 50% with a single antibiotic (mostly clarithromycin). The most common combination was clarithromycin plus rifampicin. The mean duration of therapy was more than 4 months. Complications, adverse events, and relapses were rare.Conclusions: Our findings highlight that there is a need for standardized diagnostic procedures- and therapeutic recommendations for cutaneous NTM infections.","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":"608-617"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world use of anifrolumab in refractory cutaneous lupus: case series and review of the literature. 在难治性皮肤狼疮的实际应用：病例系列和文献回顾。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1111/ddg.16004

Victoria Martínez-Sernández, Sandra Martínez-Fernández, Gonzalo Peón-Currás, Sabela Fernández-Aguado, Evelin Cecilia Cervantes-Pérez, Maria Teresa Abalde-Pintos

引用次数: 0

High-dose naloxone therapy in Darier's disease: improvement of skin lesions and pruritus. 大剂量纳洛酮治疗达里尔病：改善皮肤病变和瘙痒。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-05-01 Epub Date: 2025-12-06 DOI: 10.1111/ddg.15966

Manuel Reinhart, Felix Witte, Sonja Ständer

引用次数: 0

Cranial osteomyelitis in a patient with KID syndrome: Importance of thorough investigation in chronic wounds. KID综合征患者颅内骨髓炎：慢性伤口彻底检查的重要性。

IF 3.8 4区医学

Journal Der Deutschen Dermatologischen Gesellschaft Pub Date : 2026-05-01 Epub Date: 2025-10-16 DOI: 10.1111/ddg.15972

Michael Wolfgang Höner, Anabelle Kainz, Cornelia Erfurt-Berge

引用次数: 0