Journal Der Deutschen Dermatologischen Gesellschaft最新文献

{"title":"Erfolgreiche Behandlung eines subakut kutanen Lupus erythematodes mit dem TYK-2-Inhibitor Deucravacitinib bei einer Patientin mit begleitender Psoriasis vulgaris","authors":"Katharina Assaf, Selina Patt, Valentin Sebastian Schäfer, Jörg Wenzel, Natalija Novak, Dagmar Wilsmann-Theis","doi":"10.1111/ddg.15705_g","DOIUrl":"https://doi.org/10.1111/ddg.15705_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 7","pages":"874-877"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charakteristika von Plattenepithelkarzinomen auf Hidradenitis-suppurativa-Läsionen – eine Fallserie","authors":"Nessr Abu Rached, Riina Käpynen, Yannik Haven, Lennart Ocker, Carolin Frost, Eggert Stockfleth, Falk G. Bechara","doi":"10.1111/ddg.15708_g","DOIUrl":"https://doi.org/10.1111/ddg.15708_g","url":null,"abstract":"<p>Sehr geehrte Herausgeber,</p><p>Hidradenitis suppurativa (HS) ist eine chronisch-entzündliche Hauterkrankung, die hauptsächlich die intertriginösen Regionen betrifft. Chronische Entzündung, virale Induktion durch humane Papillomaviren (HPV), chronische Wundheilungsstörungen und hoher Tabakkonsum erhöhen das Risiko für die Entwicklung eines kutanen Plattenepithelkarzinoms (cSCC).<span><sup>1</sup></span> Insgesamt ist cSCC bei HS-Läsionen eine seltene, aber sehr schwerwiegende Komplikation der HS (Abbildung 1). Daher haben wir unsere Fälle mit cSCC retrospektiv gesammelt, um charakteristische Merkmale zu identifizieren.</p><p>Wir führten eine retrospektive Analyse an einer Kohorte von sieben Patienten mit HS durch, bei denen ein kutanes Plattenepithelkarzinom diagnostiziert wurde. Die Kohorte bestand überwiegend aus Männern (85,7 %) mit einem medianen Alter von 60 Jahren bei Erstdiagnose des kutanen Plattenepithelkarzinoms (Bereich: 42–65 Jahre) (Tabelle 1). Die mediane Erkrankungsdauer der HS zum Zeitpunkt der Diagnose des kutanen Plattenepithelkarzinoms betrug 28 Jahre (Bereich: 14–47 Jahre), was die anhaltende entzündliche Belastung im Zusammenhang mit der malignen Transformation bei diesen Patienten verdeutlicht. Alle Patienten wurden als Stadium III nach Hurley klassifiziert. Der mediane BMI betrug 25,7 kg/m<sup>2</sup> (Bereich: 21–36,4 kg/m<sup>2</sup>), was für eine typische HS-Kohorte niedrig ist. Der Raucherstatus ergab 42,9 % aktive Raucher und 57,1 % Ex-Raucher mit einer medianen Pack-Year-Anzahl von 30 (Spanne: 0–45). Die häufigsten Lokalisationen von HS waren die perineale/perianale Region (100 %), die gluteale Region (85,7 %) und die inguinale Region (71,4 %). Bei 42,9 % der Patienten wurde ein HS-assoziiertes Lymphödem diagnostiziert und 57,1 % hatten eine Biologikatherapie erhalten, darunter Secukinumab (14,3 %) und Adalimumab (42,9 %).</p><p>Hinsichtlich der tumorspezifischen Daten starben 57,1 % der Patienten an cSCC mit einer mittleren Zeit bis zum Tod von 3 Monaten (Bereich: 0–34 Monate). Die häufigsten Lokalisationen des cSCC waren die Glutealregion (42,9 %) und die Perianalregion (28,6 %). Die Tumordifferenzierungsgrade waren Grad 1 (57,1 %), Grad 2 (28,6 %) und Grad 3 (14,3 %). Metastasen waren bei 42,9 % der Patienten vorhanden. Ein Patient hatte kutane, lymphogene und pulmonale Metastasen, ein Patient hatte lymphogene Metastasen und ein Patient hatte Knochenmetastasen. Die anderen vier Patienten hatten keine lokalen oder Fernmetastasen des cSCC.</p><p>In Übereinstimmung mit der Literatur bestätigte unsere Gruppe, dass das cSCC bei HS-Läsionen hauptsächlich Männer und die untere Körperregion (insbesondere perianal/perineal) betrifft. HS-Patienten mit einem hohen Krankheitsschweregrad, der sich in hohen Entzündungsmarkern und einem Hurley-III-Befund widerspiegelt, scheinen besonders häufig von cSCC betroffen zu sein. Bemerkenswert ist der niedrige mediane BMI unserer HS-Kohorte von 25,7 kg/m<sup>2</sup> (Bereich: 21–36,4","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 7","pages":"883-886"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15708_g","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abatacept-induzierter Lupus erythematodes tumidus: Ein Fallbericht und Literaturübersicht","authors":"María Olivares-Guerrero, Ana Jiménez-Sánchez, Sonsoles Berenguer-Ruiz, Mario Aparicio-Domínguez, Mar Llamas-Velasco","doi":"10.1111/ddg.15720_g","DOIUrl":"https://doi.org/10.1111/ddg.15720_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 7","pages":"890-893"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lokalrezidiv des Nicht-Lentigo-maligna-Melanoma in situ und empfohlene Sicherheitsabstände bei der Exzision: eine systematische Übersichtsarbeit","authors":"Clio Dessinioti, Aggeliki Befon, Alexander J. Stratigos","doi":"10.1111/ddg.15699_g","DOIUrl":"https://doi.org/10.1111/ddg.15699_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 7","pages":"805-814"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sklerotische Haut beim Hutchinson-Gilford-Progerie-Syndrom: Reversibler Seneszenz-Phänotyp","authors":"Donghee Kwak, Jun-Oh Shin, Kihyuk Shin, Byungsoo Kim, Moon-Bum Kim, Yun Hak Kim, Hyun-Chang Ko","doi":"10.1111/ddg.15709_g","DOIUrl":"https://doi.org/10.1111/ddg.15709_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 7","pages":"878-881"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secukinumab for erythrodermic psoriasis combined with sepsis: three case reports.","authors":"Xinyu Zhu, Yakun Hu, Qiao Yan, Fei Wang, Zhengbang Dong","doi":"10.1111/ddg.15789","DOIUrl":"https://doi.org/10.1111/ddg.15789","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gluten-related skin disorders: clinical presentation, diagnostic and treatments","authors":"Dario Didona,&nbsp;Roberto Maglie,&nbsp;Farzan Solimani","doi":"10.1111/ddg.15704","DOIUrl":"10.1111/ddg.15704","url":null,"abstract":"<p>Gluten-related disorders (GRDs) encompass a spectrum of clinical manifestations triggered by gluten ingestion in genetically susceptible individuals. These disorders include celiac disease (CD) and non-celiac gluten sensitivity (NCGS) and present with both intestinal and extraintestinal symptoms, including skin manifestations. Besides the well-known association between CD and dermatitis herpetiformis, considered as the cutaneous manifestation of CD, other dermatoses have been associated to GRDs. In this paper, we provide a concise overview of the clinical appearance, diagnosis and therapeutic management of GRDs, a tool which we hope will facilitate clinicians when faced with this challenging group of diseases.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 7","pages":"857-867"},"PeriodicalIF":5.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15704","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognising cutaneous tuberculosis","authors":"Cathrin Gramminger,&nbsp;Tilo Biedermann","doi":"10.1111/ddg.15674","DOIUrl":"10.1111/ddg.15674","url":null,"abstract":"<p>Tuberculosis (TB) continues to be a leading cause of death in many countries, and also remains a significant concern in Germany, particularly due to migration. The diagnosis of rare cutaneous tuberculosis is challenging as it manifests in various clinical forms that resemble more common dermatological conditions.</p><p>Especially in paucibacillary forms, gold-standard diagnostic tests may yield negative results, complicating the identification of the disease. Therefore, a strong clinical suspicion based on the clinical presentation is essential for guiding further or repeated diagnostic evaluations.</p><p>In this article, we present various forms of cutaneous tuberculosis, using excerpts from the image collection of the Department of Dermatology and Allergy at Biederstein, Technical University of Munich, to improve clinical recognition of cutaneous TB and raise awareness of this condition also as a potential differential diagnosis.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"23 7","pages":"793-802"},"PeriodicalIF":5.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ddg.15674","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acneiform type of mogamulizumab-associated rash.","authors":"Inga Hansen-Abeck, Glenn Geidel, Finn Abeck, Anne Menz, Stefan W Schneider, Nina Booken","doi":"10.1111/ddg.15816","DOIUrl":"https://doi.org/10.1111/ddg.15816","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastases in the area of the skin graft donor site and partial response following anti-PD1 therapy: A case report.","authors":"Marina Schneider, Reinhard Dummer","doi":"10.1111/ddg.15817","DOIUrl":"https://doi.org/10.1111/ddg.15817","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}