Iranian Red Crescent Medical Journal最新文献

{"title":"Cross cultural adaptation, validity, and reliability of the farsi breastfeeding attrition prediction tools in Iranian pregnant women.","authors":"Forough Mortazavi,&nbsp;Seyed Abbas Mousavi,&nbsp;Reza Chaman,&nbsp;Ahmad Khosravi,&nbsp;Jill R Janke","doi":"10.5812/ircmj.26354","DOIUrl":"https://doi.org/10.5812/ircmj.26354","url":null,"abstract":"<p><strong>Background: </strong>The rate of exclusive breastfeeding in Iran is decreasing. The breastfeeding attrition prediction tools (BAPT) have been validated and used in predicting premature weaning.</p><p><strong>Objectives: </strong>We aimed to translate the BAPT into Farsi, assess its content validity, and examine its reliability and validity to identify exclusive breastfeeding discontinuation in Iran.</p><p><strong>Materials and methods: </strong>The BAPT was translated into Farsi and the content validity of the Farsi version of the BAPT was assessed. It was administered to 356 pregnant women in the third trimester of pregnancy, who were residents of a city in northeast of Iran. The structural integrity of the four-factor model was assessed in confirmatory factor analysis (CFA) and exploratory factor analysis (EFA). Reliability was assessed using Cronbach's alpha coefficient and item-subscale correlations. Validity was assessed using the known-group comparison (128 with vs. 228 without breastfeeding experience) and predictive validity (80 successes vs. 265 failures in exclusive breastfeeding).</p><p><strong>Results: </strong>The internal consistency of the whole instrument (49 items) was 0.775. CFA provided an acceptable fit to the a priori four-factor model (Chi-square/df = 1.8, Root Mean Square Error of Approximation (RMSEA) = 0.049, Standardized Root Mean Square Residual (SRMR) = 0.064, Comparative Fit Index (CFI) = 0.911). The difference in means of breastfeeding control (BFC) between the participants with and without breastfeeding experience was significant (P < 0.001). In addition, the total score of BAPT and the score of Breast Feeding Control (BFC) subscale were higher in women who were on exclusive breastfeeding than women who were not, at four months postpartum (P < 0.05).</p><p><strong>Conclusions: </strong>This study validated the Farsi version of BAPT. It is useful for researchers who want to use it in Iran to identify women at higher risks of Exclusive Breast Feeding (EBF) discontinuation.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":" ","pages":"e26354"},"PeriodicalIF":0.4,"publicationDate":"2015-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5812/ircmj.26354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34155780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowerment and coping strategies in menopause women: a review.","authors":"Mansoureh Yazdkhasti,&nbsp;Masoumeh Simbar,&nbsp;Fatemeh Abdi","doi":"10.5812/ircmj.18944","DOIUrl":"https://doi.org/10.5812/ircmj.18944","url":null,"abstract":"<p><strong>Context: </strong>Menopause is described as a period of psychological difficulties that changes the lifestyle of women in multiple ways. Menopausal women require more information about their physical and psychosocial needs. Empowerment during the menopause can contribute to improving the perception of this stage and the importance of self-care. It is essential to increase women's awareness and adaptation to menopause, using empowerment programs. The aim of this study was to review the empowerment and coping strategies in menopause women.</p><p><strong>Evidence acquisition: </strong>In this review, PubMed, EMBASE, ISI, and Iranian databases were scanned for relevant literature. A comprehensive search was performed, using the combinations of the keywords \"empowerment, menopause, coping with\" to review relevant literature and higher education journals.</p><p><strong>Results: </strong>Most interventions for menopause women have focused on educational intervention, physical activity/exercise, healthy diet, stress management, healthy behaviors, preventing certain diseases and osteoporosis. Health education intervention strategy is one of the alternative strategies for improving women's attitudes and coping with menopause symptoms, identified as severalof the subcategories of health promotion programs.</p><p><strong>Conclusions: </strong>Empowerment of menopausal women will guarantee their health during the last third of their life. It will also help them benefit from their final years of reproductive life. The results of the present study can pave the way for future research about women's health promotion and empowerment.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":" ","pages":"e18944"},"PeriodicalIF":0.4,"publicationDate":"2015-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5812/ircmj.18944","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34158060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiopulmonary resuscitation, chest compression only and teamwork from the perspective of medical doctors, surgeons and anesthesiologists.","authors":"Irena Krajina,&nbsp;Slavica Kvolik,&nbsp;Robert Steiner,&nbsp;Kristina Kovacevic,&nbsp;Ivan Lovric","doi":"10.5812/ircmj.18208","DOIUrl":"https://doi.org/10.5812/ircmj.18208","url":null,"abstract":"<p><strong>Background: </strong>New resuscitation guidelines that were proposed by the European Resuscitation Council in 2010 have introduced a new method of cardiopulmonary resuscitation (CPR) by chest compressions only for untrained individuals.</p><p><strong>Objectives: </strong>We conducted this study to evaluate differences in attitudes towards CPR among medical doctors, surgeons and anesthesiologists in Osijek University Hospital. A call for help, chest-compression-only resuscitation, mouth-to-mouth ventilation and team-work were recognized as critical points that may influence the outcome. Unfamiliarity with these methods may be indicative of a lack of education in resuscitation and may result in poor outcomes for victims.</p><p><strong>Patients and methods: </strong>An anonymous survey was conducted on 190 medical professionals: 93 medical doctors, 70 surgeons, and 27 anesthesiologists during year 2012 (mean age 41.9 years). The questions were related to previous education in resuscitation, current resuscitation practices and attitudes towards cardiopulmonary resuscitation. Data were analyzed using ANOVA and Fisher exact test. A P value of < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The only difference between groups was regarding the male and female ratio, with more male surgeons (45, 55, and 11, P < 0.001). All doctors considered CPR as important, but only anesthesiologists knew how often guidelines in CPR change. Approximately 45% of medical doctors, 48% of surgeons and 77% of anesthesiologists reported that they have renewed their knowledge in CPR within the last five years, whereas 34%, 25% and 22% had never renewed their knowledge in the CPR (P = 0.01 between surgeons anesthesiologists). Furthermore, chest-compression-only was recognized as a valuable CPR technique by 25.8% of medical doctors, 14.3% of surgeons and 59.3% of anesthesiologists (P < 0.001). Anesthesiologists estimated a high risk of infection transmission (62%) and were more likely to refuse mouth-to-mouth ventilation when compared to surgeons (25% vs.10%, P = 0.01). Anesthesiologists are most often called for help by their colleagues, only rarely surgeons call their departmental colleagues and nurses to help in CPR.</p><p><strong>Conclusions: </strong>An insufficient formal education in CPR was registered for all groups, reflecting the lack of familiarity with new CPR methods. A team education, involving doctors and nurses may improve familiarity with CPR and patient outcomes.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":" ","pages":"e18208"},"PeriodicalIF":0.4,"publicationDate":"2015-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/52/5c/ircmj-17-03-18208.PMC4441776.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34158058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing of the appropriateness evaluation protocol for public hospitals in iran.","authors":"Anvar Esmaili,&nbsp;Hamid Ravaghi,&nbsp;Hesam Seyedin,&nbsp;Bahram Delgoshaei,&nbsp;Masoud Salehi","doi":"10.5812/ircmj.19030","DOIUrl":"https://doi.org/10.5812/ircmj.19030","url":null,"abstract":"<p><strong>Background: </strong>Employment of utilization review instruments is a method for managing costs and efficiency in the healthcare systems.</p><p><strong>Objectives: </strong>This study developed an instrument for measuring the level of inappropriate acute hospital admissions and days of care in Iran.</p><p><strong>Patients and methods: </strong>The American version of the Appropriateness Evaluation Protocol (AEP) was modified, using the agreement method, by a multidisciplinary group of physicians. We conducted a retrospective descriptive study of 273 randomly selected patients admitted to Imam Khomeini Hospital of Tehran University of Medical Sciences in Tehran, Iran. For the reliability study, two nurses were asked to review patients' medical records using the instrument. Validity was appraised by pairs of clinicians, including two general surgeons, two internists and two gynecologists. The degree of consensus between the three pairs of clinicians was compared with that of the nurses.</p><p><strong>Results: </strong>Inter-rater and intra-rater reliability testing revealed an excellent level of consensus between the two nurses employing the AEP in all the studied departments. Overall agreement was > 92%, while the specific appropriate agreement and specific inappropriate agreement were > 88% and > 83%, respectively. External validity testing of the instrument yielded a sensitivity > 0.785, specificity > 0.55, and positive and negative predictive values > 0.775 and > 0.555, respectively. The kappa statistic for the nurses who applied the AEP and clinicians using personal judgment were perfect (k > 0.85) and substantial (k > 0.68), respectively.</p><p><strong>Conclusions: </strong>The results illustrate that the Iranian version of the AEP (IR-AEP) could be a reliable and valid instrument for assessing the level of inappropriate acute hospital admissions and days of care in the Iranian context.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":" ","pages":"e19030"},"PeriodicalIF":0.4,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/57/ircmj-17-03-19030.PMC4441772.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34225735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual patient data meta-analysis of the smoking prevalence in mazandaran province of iran.","authors":"Mahmood Moosazadeh,&nbsp;Mohammadreza Amiresmaili,&nbsp;Mahdi Afshari","doi":"10.5812/ircmj.10294","DOIUrl":"https://doi.org/10.5812/ircmj.10294","url":null,"abstract":"<p><strong>Background: </strong>Smoking is regarded as one of the main risk factors and additive to the global burden of diseases in the World.</p><p><strong>Objectives: </strong>This individual patient data (IPD) meta-analysis aimed to estimate the smoking prevalence in Mazandaran province of Iran.</p><p><strong>Materials and methods: </strong>This study was an IPD meta-analysis. The study data were part of the STEPS Study in Mazandaran province (northern Iran), conducted annually from 2005 to 2009. Sample size was 7759 subjects. Sampling method was census. Data entry was in Epi6 software and the analyses were with stata 11 software.</p><p><strong>Results: </strong>Mean (standard error) age of starting to smoke was 20.21 (0.6) years and females had started smoking 4 years later (P = 0.01). During the study, men smoked cigarettes more than women (total prevalence: 23.2%; 95% CI: 22.5-23.9 vs. 0.9%; 95% CI: 0.7-1.1 respectively). The pooled prevalence of the current smoking was estimated about 12.08 % (95% CI: 11.40-12.81).</p><p><strong>Conclusions: </strong>Present study showed that the prevalence of Smoking in men is very high in this region of Iran. Therefore to prevent the problem it is necessary that educational and research centres and health providers make suitable policies and strategies .</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":"17 2","pages":"e10294"},"PeriodicalIF":0.4,"publicationDate":"2015-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/56/ircmj-17-02-10294.PMC4353219.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33147562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized, clinical trial on diathermy and scalpel incisions in elective general surgery.","authors":"Altaf Ahmed Talpur, Abdul Basir Khaskheli, Nandlal Kella, Akmal Jamal","doi":"10.5812/ircmj.14078","DOIUrl":"10.5812/ircmj.14078","url":null,"abstract":"<p><strong>Background: </strong>Since a long time skin incisions have routinely been made with scalpels. Now a day there is a shift in trend from this method to electrosurgical skin incisions. However, fear of bad scars and improper wound healing has prevented its wide spread use. This Study aimed to compare both methods of skin incisions for different variables.</p><p><strong>Objectives: </strong>The aim of this study was to examine incisional time, blood loss during incision and postoperative wound complications and pain with both methods of skin incision.</p><p><strong>Patients and methods: </strong>A prospective, comparative and randomized study was conducted at different hospitals of Hyderabad and Nawabshah, Pakistan from 1(st) of December 2009 to 30(th) of November 2011. The study included patients of either sex above the age of five years with general surgical pathology who were to undergo surgery. these candidates were randomly put into two groups. In Group A patients incision was made with a scalpel and in group B with diathermy. Data was analyzed for age, sex, comorbid illness, incisional time, blood loss during incision making and postoperative pain and wound complications.</p><p><strong>Results: </strong>A total of 283 patients completed the follow-up and were included in the final analysis. Group A comprised of 143 (50.53%) patients; 83 (58%) males and 60 (42%) females with a mean age of 36.03 years. Amongst the 140 patients of group B, there were 85 (60.7%) males and 55 (39.3%) females with a mean age of 36.52 years. Twenty-five (17.48%) patients of group A and 27 (19.28%) of group B had comorbid illnesses. Mean incision time was 8.9025-sec/cm(2) for group A and 7.3057 sec/cm(2) for group B patients. Mean blood loss during incision making was 1.8262 mL/cm(2) and 1.1346 mL/cm(2) for group A and B patients, respectively. Pain was 5.2957 for group A patients on day one and 3.1181 for group B patients. Pain score was 2.1049 and 1.6206 on day two and 0.8191 and 0.7192 on day five, for group A and B patients, respectively. Postoperative wound complications were noticed in 26 (18.18%) patients of group A and 22 (15.71%) patients of group B.</p><p><strong>Conclusions: </strong>Diathermy incision is a safe and expedient technique. It takes less time than scalpel incision and loss of blood is also lower during incision. Diathermy is associated with lesser post-operative pain and complications than the scalpel incision. Diathermy should be method of choice in general elective surgery.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":"17 2","pages":"e14078"},"PeriodicalIF":0.4,"publicationDate":"2015-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/94/ircmj-17-02-14078.PMC4376978.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33182958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal Calprotectin is an Accurate Tool and Correlated to Seo Index in Prediction of Relapse in Iranian Patients With Ulcerative Colitis.","authors":"Seyed Vahid Hosseini,&nbsp;Peyman Jafari,&nbsp;Seyed Alireza Taghavi,&nbsp;Ali Reza Safarpour,&nbsp;Abbas Rezaianzadeh,&nbsp;Maryam Moini,&nbsp;Manoosh Mehrabi","doi":"10.5812/ircmj.22796","DOIUrl":"https://doi.org/10.5812/ircmj.22796","url":null,"abstract":"<p><strong>Background: </strong>The natural clinical course of Ulcerative Colitis (UC) is characterized by episodes of relapse and remission. Fecal Calprotectin (FC) is a relatively new marker of intestinal inflammation and is an available, non-expensive tool for predicting relapse of quiescent UC. The Seo colitis activity index is a clinical index for assessment of the severity of UC.</p><p><strong>Objectives: </strong>The present study aimed to evaluate the accuracy of FC and the Seo colitis activity index and their correlation in prediction of UC exacerbation.</p><p><strong>Patients and methods: </strong>In this prospective cohort study, 157 patients with clinical and endoscopic diagnosis of UC selected randomly from 1273 registered patients in Fars province's IBD registry center in Shiraz, Iran, were followed from October 2012 to October 2013 for 12 months or shorter, if they had a relapse. Two patients left the study before completion and one patient had relapse because of discontinuation of drugs. The participants' clinical and serum factors were evaluated every three months. Furthermore, stool samples were collected at the beginning of study and every three months and FC concentration (commercially available enzyme linked immunoassay) and the Seo Index were assessed. Then univariate analysis, multiple variable logistic regression, Receiver Operating Characteristics (ROC) curve analysis, and Pearson's correlation test (r) were used for statistical analysis of data.</p><p><strong>Results: </strong>According to the results, 74 patients (48.1%) relapsed during the follow-up (33 men and 41 women). Mean ± SD of FC was 862.82 ± 655.97 μg/g and 163.19 ± 215.85 μg/g in relapsing and non-relapsing patients, respectively (P < 0.001). Multiple logistic regression analysis revealed that age, number of previous relapses, FC and the Seo index were significant predictors of relapse. ROC curve analysis of FC level and Seo activity index for prediction of relapse demonstrated area under the curve of 0.882 (P < 0.001) and 0.92 1(P < 0.001), respectively. Besides, FC level of 341 μg/g was identified as the cut-off point with 11.2% and 79.7% relapse rate below and above this point, respectively. Additionally, Pearson correlation coefficient (r) between FC and the Seo index was significant in prediction of relapse (r = 0.63, P < 0.001).</p><p><strong>Conclusions: </strong>As a simple and noninvasive marker, FC is highly accurate and significantly correlated to the Seo activity index in prediction of relapse in the course of quiescent UC in Iranian patients.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":"17 2","pages":"e22796"},"PeriodicalIF":0.4,"publicationDate":"2015-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/df/ircmj-17-02-22796.PMC4353186.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33147024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy experiences of first-time fathers in iran: a qualitative interview study.","authors":"Shahnaz Golian Tehrani,&nbsp;Shahin Bazzazian,&nbsp;Nahid Dehghan Nayeri","doi":"10.5812/ircmj.12271","DOIUrl":"https://doi.org/10.5812/ircmj.12271","url":null,"abstract":"<p><strong>Background: </strong>Fatherhood, similarly to motherhood, is an important role and responsibility. For accepting this role, one needs to be well-prepared. Awareness of father's experiences of pregnancy can help us to develop plans for the promotion of the role of fatherhood.</p><p><strong>Objectives: </strong>The purpose of this study was to explore how first time fathers describe their experiences of pregnancy.</p><p><strong>Patients and methods: </strong>The data in this qualitative study were collected by individual open-ended interviews in five public health prenatal care clinics in Tehran, Iran, during 2010 ‒ 2011. Participants were 26 Iranian and Moslem first-time fathers living in Tehran, whose partner was in the 32th to 40th week of her normal pregnancy. Qualitative content text analysis was used for analyzing interviews.</p><p><strong>Results: </strong>Through analysis of fathers' experiences of their wives' pregnancy, four categories, as well as associated subcategories, emerged. The categories include: \"Emotional responses to pregnancy, Feeling of change, Accepting the reality and satisfaction, Developing identity as a father.\" These categories describe the phenomenon of \"Transition to fatherhood\".</p><p><strong>Conclusions: </strong>Transition to fatherhood extends beyond only moderate mental and social changes, and may be influenced by cultural background and beliefs. Therefore, caregivers should be aware of fathers' changes and needs during pregnancy, and support them while taking into consideration their culture and beliefs.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":"17 2","pages":"e12271"},"PeriodicalIF":0.4,"publicationDate":"2015-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5812/ircmj.12271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33188263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monoamine oxidase a gene polymorphisms and bipolar disorder in Iranian population.","authors":"Mohammad Reza Eslami Amirabadi,&nbsp;Sepideh Rajezi Esfahani,&nbsp;Rozita Davari-Ashtiani,&nbsp;Mojgan Khademi,&nbsp;Babak Emamalizadeh,&nbsp;Abolfazl Movafagh,&nbsp;Said Sadr,&nbsp;Fariba Arabgol,&nbsp;Hossein Darvish,&nbsp;Katayoon Razjoyan","doi":"10.5812/ircmj.23095","DOIUrl":"https://doi.org/10.5812/ircmj.23095","url":null,"abstract":"<p><strong>Background: </strong>Bipolar disorder (BPD) is a common and severe mood disorder. Although genetic factors have important rolesin the etiology of bipolar disorder, no specific gene has been identified in relation to this disorder. Monoamine oxidase gene is suggested to be associated with bipolar disorder in many studies.</p><p><strong>Objectives: </strong>This study aimed to investigatethe role of MAOA gene polymorphisms in the etiology of bipolar disorder in Iranian population.</p><p><strong>Patients and methods: </strong>This study is a case-control study, with convenient sampling. Three common polymorphisms, a CA microsatellite, a VNTR, and a RFLP were typed in 156 bipolar patients and 173 healthy controls. Patients were chosen from Imam Hossein General Hospital, Psychiatry Ward (Tehran/Iran). Controlsamples for this study consisted of 173 healthy individuals recruitedby convenient sampling. Allelic distributions of these polymorphisms were analyzed in bipolar and control groups to investigate any association with MAOA gene.</p><p><strong>Results: </strong>Significant associations were observed regarding MAOA-CA (P = 0.016) and MAOA-VNTR (P = 0.004) polymorphisms in the bipolar females. There was no association between MAOA-RFLP and bipolar disorder.</p><p><strong>Conclusions: </strong>The obtained results confirm some previous studies regardinga gender specific association of MAOA gene with the bipolar disorder.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":"17 2","pages":"e23095"},"PeriodicalIF":0.4,"publicationDate":"2015-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2a/a9/ircmj-17-02-23095.PMC4353216.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33147026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (rs4646994) and VEGF Polymorphism (+405G/C; rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes.","authors":"Mohammad Fathi,&nbsp;Abdol Rahim Nikzamir,&nbsp;Alireza Esteghamati,&nbsp;Manouchehr Nakhjavani,&nbsp;Mir Saeed Yekaninejad","doi":"10.5812/ircmj.19469","DOIUrl":"https://doi.org/10.5812/ircmj.19469","url":null,"abstract":"<p><strong>Background: </strong>Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and vascular endothelial growth factor (VEGF) polymorphisms have been shown to associate with diabetic nephropathy (DN).</p><p><strong>Objectives: </strong>We examined the hypothesis that ACE-D and VEGF-G alleles act synergistically in association with DN, in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Patients and methods: </strong>The VEGF (rs2010963) and ACE (rs4646994) genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 490 T2DM patients. Diabetic patients were classified as T2DM patients with and without albuminuria (control). The PCR and RFLP were used to detect the VEGF and ACE alleles.</p><p><strong>Results: </strong>A total of 255 consecutive patients with T2DM and microalbuminuria (Group A) and 235 patients with T2DM and normoalbuminuria (Group B) were included in the study. In univariate analysis, the groups were statistically similar for all variables, except for glycated hemoglobin (HbA1c) (P = 0.034), and the frequency of ACE (P = 0.015) and VEGF (P = 0.006) genotypes. Our study showed that the VEGF-G and ACE-D alleles are independently associated with the development of nephropathy. According to our data, the combination of these two risk factors had a significant synergistic effect on the risk of microalbuminuria development.</p><p><strong>Conclusions: </strong>Our study indicated that ACE-D and VEGF-G alleles can be an independent risk factor for microalbominuria in T2DM patients.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":"17 2","pages":"e19469"},"PeriodicalIF":0.4,"publicationDate":"2015-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/9c/ircmj-17-02-19469.PMC4376980.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33182960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}