Monoamine oxidase a gene polymorphisms and bipolar disorder in Iranian population.

IF 0.4 4区医学

Iranian Red Crescent Medical Journal Pub Date : 2015-02-21 eCollection Date: 2015-02-01 DOI:10.5812/ircmj.23095

Mohammad Reza Eslami Amirabadi, Sepideh Rajezi Esfahani, Rozita Davari-Ashtiani, Mojgan Khademi, Babak Emamalizadeh, Abolfazl Movafagh, Said Sadr, Fariba Arabgol, Hossein Darvish, Katayoon Razjoyan

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引用次数: 6

Abstract

Background: Bipolar disorder (BPD) is a common and severe mood disorder. Although genetic factors have important rolesin the etiology of bipolar disorder, no specific gene has been identified in relation to this disorder. Monoamine oxidase gene is suggested to be associated with bipolar disorder in many studies.

Objectives: This study aimed to investigatethe role of MAOA gene polymorphisms in the etiology of bipolar disorder in Iranian population.

Patients and methods: This study is a case-control study, with convenient sampling. Three common polymorphisms, a CA microsatellite, a VNTR, and a RFLP were typed in 156 bipolar patients and 173 healthy controls. Patients were chosen from Imam Hossein General Hospital, Psychiatry Ward (Tehran/Iran). Controlsamples for this study consisted of 173 healthy individuals recruitedby convenient sampling. Allelic distributions of these polymorphisms were analyzed in bipolar and control groups to investigate any association with MAOA gene.

Results: Significant associations were observed regarding MAOA-CA (P = 0.016) and MAOA-VNTR (P = 0.004) polymorphisms in the bipolar females. There was no association between MAOA-RFLP and bipolar disorder.

Conclusions: The obtained results confirm some previous studies regardinga gender specific association of MAOA gene with the bipolar disorder.

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单胺氧化酶基因多态性与伊朗人群双相情感障碍。

背景:双相情感障碍(BPD)是一种常见且严重的情绪障碍。尽管遗传因素在双相情感障碍的病因学中起着重要作用，但尚未确定与该疾病相关的特定基因。许多研究表明单胺氧化酶基因与双相情感障碍有关。目的:本研究旨在调查MAOA基因多态性在伊朗人群双相情感障碍病因学中的作用。患者和方法:本研究为病例对照研究，取样方便。在156名双相患者和173名健康对照中分型了三种常见多态性，CA微卫星、VNTR和RFLP。患者选自伊玛目侯赛因总医院精神病病房(德黑兰/伊朗)。本研究的对照样本包括173名健康个体，采用方便抽样方法。在双相情感障碍组和对照组中分析这些多态性的等位基因分布，以调查是否与MAOA基因有关。结果:在双相情感障碍女性中观察到mao - ca (P = 0.016)和mao - vntr (P = 0.004)多态性的显著相关性。MAOA-RFLP与双相情感障碍无关联。结论:本研究结果证实了先前关于MAOA基因与双相情感障碍存在性别特异性关联的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Red Crescent Medical Journal 医学-医学：内科

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期刊介绍： The IRANIAN RED CRESCENT MEDICAL JOURNAL is an international, English language, peer-reviewed journal dealing with general Medicine and Surgery, Disaster Medicine and Health Policy. It is an official Journal of the Iranian Hospital Dubai and is published monthly. The Iranian Red Crescent Medical Journal aims at publishing the high quality materials, both clinical and scientific, on all aspects of Medicine and Surgery

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