{"title":"单胺氧化酶基因多态性与伊朗人群双相情感障碍。","authors":"Mohammad Reza Eslami Amirabadi, Sepideh Rajezi Esfahani, Rozita Davari-Ashtiani, Mojgan Khademi, Babak Emamalizadeh, Abolfazl Movafagh, Said Sadr, Fariba Arabgol, Hossein Darvish, Katayoon Razjoyan","doi":"10.5812/ircmj.23095","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Bipolar disorder (BPD) is a common and severe mood disorder. Although genetic factors have important rolesin the etiology of bipolar disorder, no specific gene has been identified in relation to this disorder. Monoamine oxidase gene is suggested to be associated with bipolar disorder in many studies.</p><p><strong>Objectives: </strong>This study aimed to investigatethe role of MAOA gene polymorphisms in the etiology of bipolar disorder in Iranian population.</p><p><strong>Patients and methods: </strong>This study is a case-control study, with convenient sampling. Three common polymorphisms, a CA microsatellite, a VNTR, and a RFLP were typed in 156 bipolar patients and 173 healthy controls. Patients were chosen from Imam Hossein General Hospital, Psychiatry Ward (Tehran/Iran). Controlsamples for this study consisted of 173 healthy individuals recruitedby convenient sampling. Allelic distributions of these polymorphisms were analyzed in bipolar and control groups to investigate any association with MAOA gene.</p><p><strong>Results: </strong>Significant associations were observed regarding MAOA-CA (P = 0.016) and MAOA-VNTR (P = 0.004) polymorphisms in the bipolar females. There was no association between MAOA-RFLP and bipolar disorder.</p><p><strong>Conclusions: </strong>The obtained results confirm some previous studies regardinga gender specific association of MAOA gene with the bipolar disorder.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2015-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2a/a9/ircmj-17-02-23095.PMC4353216.pdf","citationCount":"6","resultStr":"{\"title\":\"Monoamine oxidase a gene polymorphisms and bipolar disorder in Iranian population.\",\"authors\":\"Mohammad Reza Eslami Amirabadi, Sepideh Rajezi Esfahani, Rozita Davari-Ashtiani, Mojgan Khademi, Babak Emamalizadeh, Abolfazl Movafagh, Said Sadr, Fariba Arabgol, Hossein Darvish, Katayoon Razjoyan\",\"doi\":\"10.5812/ircmj.23095\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Bipolar disorder (BPD) is a common and severe mood disorder. Although genetic factors have important rolesin the etiology of bipolar disorder, no specific gene has been identified in relation to this disorder. Monoamine oxidase gene is suggested to be associated with bipolar disorder in many studies.</p><p><strong>Objectives: </strong>This study aimed to investigatethe role of MAOA gene polymorphisms in the etiology of bipolar disorder in Iranian population.</p><p><strong>Patients and methods: </strong>This study is a case-control study, with convenient sampling. Three common polymorphisms, a CA microsatellite, a VNTR, and a RFLP were typed in 156 bipolar patients and 173 healthy controls. Patients were chosen from Imam Hossein General Hospital, Psychiatry Ward (Tehran/Iran). Controlsamples for this study consisted of 173 healthy individuals recruitedby convenient sampling. Allelic distributions of these polymorphisms were analyzed in bipolar and control groups to investigate any association with MAOA gene.</p><p><strong>Results: </strong>Significant associations were observed regarding MAOA-CA (P = 0.016) and MAOA-VNTR (P = 0.004) polymorphisms in the bipolar females. There was no association between MAOA-RFLP and bipolar disorder.</p><p><strong>Conclusions: </strong>The obtained results confirm some previous studies regardinga gender specific association of MAOA gene with the bipolar disorder.</p>\",\"PeriodicalId\":14628,\"journal\":{\"name\":\"Iranian Red Crescent Medical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2015-02-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2a/a9/ircmj-17-02-23095.PMC4353216.pdf\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Red Crescent Medical Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5812/ircmj.23095\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2015/2/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Red Crescent Medical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5812/ircmj.23095","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2015/2/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Monoamine oxidase a gene polymorphisms and bipolar disorder in Iranian population.
Background: Bipolar disorder (BPD) is a common and severe mood disorder. Although genetic factors have important rolesin the etiology of bipolar disorder, no specific gene has been identified in relation to this disorder. Monoamine oxidase gene is suggested to be associated with bipolar disorder in many studies.
Objectives: This study aimed to investigatethe role of MAOA gene polymorphisms in the etiology of bipolar disorder in Iranian population.
Patients and methods: This study is a case-control study, with convenient sampling. Three common polymorphisms, a CA microsatellite, a VNTR, and a RFLP were typed in 156 bipolar patients and 173 healthy controls. Patients were chosen from Imam Hossein General Hospital, Psychiatry Ward (Tehran/Iran). Controlsamples for this study consisted of 173 healthy individuals recruitedby convenient sampling. Allelic distributions of these polymorphisms were analyzed in bipolar and control groups to investigate any association with MAOA gene.
Results: Significant associations were observed regarding MAOA-CA (P = 0.016) and MAOA-VNTR (P = 0.004) polymorphisms in the bipolar females. There was no association between MAOA-RFLP and bipolar disorder.
Conclusions: The obtained results confirm some previous studies regardinga gender specific association of MAOA gene with the bipolar disorder.
期刊介绍：
The IRANIAN RED CRESCENT MEDICAL JOURNAL is an international, English language, peer-reviewed journal dealing with general Medicine and Surgery, Disaster Medicine and Health Policy. It is an official Journal of the Iranian Hospital Dubai and is published monthly. The Iranian Red Crescent Medical Journal aims at publishing the high quality materials, both clinical and scientific, on all aspects of Medicine and Surgery
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