Iranian Journal of Otorhinolaryngology最新文献_第10页

Sinonasal Neuroendocrine Carcinoma in Adult Proteus Syndrome. 成人普罗蒂斯综合征中的鼻窦神经内分泌癌

Iranian Journal of Otorhinolaryngology Pub Date : 2023-11-01 DOI: 10.22038/IJORL.2023.73128.3472

Giorgos Sideris, Thomas Nikolopoulos, Antigone Sourla, Penelope Korkolopoulou, Pavlos Papadakis, Alexander Delides

{"title":"Sinonasal Neuroendocrine Carcinoma in Adult Proteus Syndrome.","authors":"Giorgos Sideris, Thomas Nikolopoulos, Antigone Sourla, Penelope Korkolopoulou, Pavlos Papadakis, Alexander Delides","doi":"10.22038/IJORL.2023.73128.3472","DOIUrl":"https://doi.org/10.22038/IJORL.2023.73128.3472","url":null,"abstract":"Introduction: Proteus syndrome (PS) is a rare genetic disorder usually caused by mutations in AKT1 or PTEN genes, characterized by multiple, asymmetric tissue overgrowth with high clinical variability. Sinonasal neuroendocrine carcinomas (SNEC) are exceptionally rare tumors encountered in the ethmoid sinus, nasal cavity, or maxillary sinus.Case report: We report a 35-year-old patient with PS, who underwent successful surgical removal of a well-differentiated SNEC obstructing his nasal cavity and highlight the role of the otolaryngologist for safe airway management, minimal surgical intervention and coordination of the multidisciplinary care. Histologically, focally hyperplastic mucosal epithelium of respiratory type of the nasal chamber was noticed along with seromucinous glands and capillary congestion of the subepithelial fibrovascular tissue. The limited presence of neoplastic tissue with histomorphological and immunophenotypic features of a neuroendocrine neoplasm was focally observed. Tumor cells grow in the form of islets within a vascular stroma; these neoplastic cells are immunohistochemically positive for synaptophysin, CD56, EMA, Ki67 (low expression, cell proliferation rate: 2%), CD31, chromogranin and pancytokeratin AE1 / AE3 as well as for S-100 protein (weak intensity).Conclusions: This first description of a SNEC in a PS patient, might hint towards a common basis between the two conditions, due to the mosaic AKT1 variant and an activated AKT/PIK3CA/PTEN pathway.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 131","pages":"321-324"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138798268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Immunohistochemical Expression of TRAP in Odontogenic Cysts. 牙源性囊肿中 TRAP 的免疫组化表达比较。

Iranian Journal of Otorhinolaryngology Pub Date : 2023-11-01 DOI: 10.22038/IJORL.2023.63350.3169

Hamideh Kadeh, Shirin Saravani, Ali Jamshidi

{"title":"A Comparative Immunohistochemical Expression of TRAP in Odontogenic Cysts.","authors":"Hamideh Kadeh, Shirin Saravani, Ali Jamshidi","doi":"10.22038/IJORL.2023.63350.3169","DOIUrl":"https://doi.org/10.22038/IJORL.2023.63350.3169","url":null,"abstract":"Introduction: Tartrate-resistant acid phosphatase (TRAP) is an acid phosphatase metalloprotein enzyme expressed in osteoclasts and is related to bone resorption. The molecular mechanisms involved in the different behavior of odontogenic keratocysts have not yet been fully elucidated. The purpose of this study was to compare TRAP expression in odontogenic keratocysts, radicular cysts, and dentigerous cysts.Materials and methods: In this cross-sectional study, we selected 60 samples, including 20 cases of each one of the odontogenic keratocysts (OKC), radicular cysts (RC) and dentigerous cysts (DC). The samples were stained with TRAP monoclonal antibodies using immunohistochemistry. The data were analyzed using the Chi-Square and Kruskal-Wallis tests.Results: In this study, TRAP expression was observed in the lining epithelium of 50% of OKC cases and 5% of RC cases, while it was negative in the lining epithelium of DC. This difference was statistically significant (p<0.001). Moreover, the TRAP staining intensity in the lining epithelium had a significant difference between the groups (P<0.001). TRAP expression in the connective tissue of OKC, RC, and DC was positive in 35%, 30%, and 20% of the cases, respectively. This difference was not statistically significant (P=0.788). Also, staining intensity of TRAP-positive cells in the connective tissue of the lesions was not significant (P=0.634).Conclusion: In this study, we found a higher expression of TRAP in the lining epithelium of OKC, which may be one of the reasons for the aggressive behavior of OKC compared to other cysts. This finding supports the classification of OKC as an odontogenic tumor.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 131","pages":"295-301"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Solitary Fibrosus Tumor (SFT) of the Nasal Septum. 鼻中隔孤立性纤维瘤（SFT）的罕见病例。

Iranian Journal of Otorhinolaryngology Pub Date : 2023-11-01 DOI: 10.22038/IJORL.2023.72285.3450

Davide Burrascano, Salvatore Dolores, Angelo Immordino, Francesco Lorusso, Francesco Dispenza, Federico Sireci

{"title":"A Rare Case of Solitary Fibrosus Tumor (SFT) of the Nasal Septum.","authors":"Davide Burrascano, Salvatore Dolores, Angelo Immordino, Francesco Lorusso, Francesco Dispenza, Federico Sireci","doi":"10.22038/IJORL.2023.72285.3450","DOIUrl":"https://doi.org/10.22038/IJORL.2023.72285.3450","url":null,"abstract":"Introduction: Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that usually arises from the pleura but can also occur in extrapleural sites, such as the sinonasal region. It causes aspecific symptoms, including nasal obstruction and discharge, postnasal drip, anosmia, epistaxis, and headache. It may be difficult to distinguish these symptoms from those caused by other mesenchymal lesions that usually occur in this site, especially when the tissues undergo iatrogenic damage following surgical removal.Case report: This case report shows a rare right nasal septal solitary fibrous tumor, which was surgically removed using a trans-nasal endoscopic technique. For the first time, the mass was decomposed by a plasma blade, and the implant site was treated by performing a subperiosteal removal of septal mucosa and cartilage. Histopathological examination confirmed the diagnosis of solitary fibrous tumor. Follow-up at three, six, and twelve months showed no signs of relapse.Conclusions: Sinonasal SFT is unusual, and it may be difficult to distinguish it from other mesenchymal lesions in this site. In the literature, cases treated with CO2 laser are usually described; however, due to the high cutting temperatures, this can cause thermal damage of the tissues, making histopathological diagnosis difficult. The plasma blade uses pulsed radiofrequency, creating an effective cutting edge while the blade stays near body temperature. Therefore, this device results in atraumatic, scalpel-like cutting sensitivity and electrosurgical-like hemostasis, with minimal bleeding and tissue injury. Its use could, therefore, help both the surgeon in obtaining surgical radicality and the pathologist in the correct histologic classification.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 131","pages":"329-334"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ectopic Papillary Thyroid Carcinoma of the Posterior Pharynx. 咽后异位甲状腺乳头状癌

Iranian Journal of Otorhinolaryngology Pub Date : 2023-11-01 DOI: 10.22038/IJORL.2023.73099.3471

Chang Haur Lee, Firdaus Hayati, Nornazirah Azizan, Siti Zubaidah Sharif

{"title":"Ectopic Papillary Thyroid Carcinoma of the Posterior Pharynx.","authors":"Chang Haur Lee, Firdaus Hayati, Nornazirah Azizan, Siti Zubaidah Sharif","doi":"10.22038/IJORL.2023.73099.3471","DOIUrl":"https://doi.org/10.22038/IJORL.2023.73099.3471","url":null,"abstract":"Introduction: Ectopic thyroid is an uncommon condition resulting from the aberrant development of the normal thyroid gland and is usually found along the thyroglossal tract: lingual, submandibular, thyroglossal cysts, intra-tracheal and mediastinal, or, on rare occasions, in the adrenal gland, gallbladder, gastrointestinal tract, pancreas, and struma ovarii.Case reports: We describe a novel case where primary papillary thyroid carcinoma (PTC) was found after a trans-oral excision of a tumor containing ectopic thyroid tissue at the posterior pharynx, an area not known to be a location for ectopic thyroid. Delays due to the COVID-19 pandemic resulted in regional cervical metastases and multifocal PTC. The female patient successfully underwent total thyroidectomy, selective cervical and central lymph node dissection, followed by adjuvant radioactive iodine ablation, with no evidence of distant metastases.Conclusions: Ectopic thyroid tissue is uncommon and may be in the posterior pharynx. The principles of management remain those of differentiated thyroid malignancy: complete surgical resection of any tumor focus, total thyroidectomy, and node dissection of involved lymph nodes, followed by adjuvant radioactive iodine in iodine-sensitive tumors.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 131","pages":"325-328"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Corticosteroids on Post-Covid-19 Smell Loss: A Meta-Analysis. 皮质类固醇对 Covid-19 后嗅觉丧失的影响：一项 Meta 分析。

Iranian Journal of Otorhinolaryngology Pub Date : 2023-09-01 DOI: 10.22038/IJORL.2023.72451.3456

Mona Kabiri, Maryam Emadzadeh

{"title":"The Effect of Corticosteroids on Post-Covid-19 Smell Loss: A Meta-Analysis.","authors":"Mona Kabiri, Maryam Emadzadeh","doi":"10.22038/IJORL.2023.72451.3456","DOIUrl":"https://doi.org/10.22038/IJORL.2023.72451.3456","url":null,"abstract":"Introduction: The rate of olfactory loss related to COVID-19 was reported between 4-89 percent. There is no approved treatment for patients who experience anosmia after the mentioned infection. This systematic review aimed to assess the therapeutic effects of corticosteroids on anosmia in COVID-19 patients.Materials and methods: Databases including PubMed, ISI Web of Sciences, Scopus, and Cochrane Library. Databases were searched up to September 2022 to find out randomized controlled trials that assessed the effect of corticosteroids on post-COVID anosmia/hyposmia. Only studies published in the English language were entered in this review.Results: Among the six relevant trials with a total population of 712, one study administered the combination therapy of both systemic and nasal corticosteroids, while others used intranasal corticosteroids. No significant difference was observed between the intervention (IG) and control (CG) groups in terms of duration of improvement from anosmia (mean difference:-1.799). The pooled effect of self-rating olfactory scores was assessed at 2 weeks and at the end point of the studies which revealed no significant effect in favor of the IG (pooled effect in 2 weeks: 0.739; in the endpoint: 1.32). The objective evaluation with different tools indicated that IG obtained higher scores at the endpoint of treatment. The pooled results showed that the number of patients who recovered from anosmia is higher in IG compared to CG (Odds Ratio: 1.719).Conclusion: It appears that the duration of corticosteroid therapy more than two weeks may be a considerable effect on the recovery of smell dysfunction in COVID-19 patients.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 130","pages":"235-246"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Level of Vitamin D in Patients with Salivary Gland Tumors. 唾液腺肿瘤患者的血清维生素 D 水平。

Iranian Journal of Otorhinolaryngology Pub Date : 2023-09-01 DOI: 10.22038/IJORL.2023.69088.3346

Sedigheh Moayedi, Bijan Khademi, Mahyar Malekzadeh, Golnoush Farzinnia, Zohreh Jaafari-Ashkavandi

{"title":"Serum Level of Vitamin D in Patients with Salivary Gland Tumors.","authors":"Sedigheh Moayedi, Bijan Khademi, Mahyar Malekzadeh, Golnoush Farzinnia, Zohreh Jaafari-Ashkavandi","doi":"10.22038/IJORL.2023.69088.3346","DOIUrl":"https://doi.org/10.22038/IJORL.2023.69088.3346","url":null,"abstract":"Introduction: The active vitamin D metabolites have anticancer effects on many human neoplasms. The vitamin D receptors have been detected in salivary glands tissue. This study aimed to evaluate the serum level of vitamin D in patients with malignant and benign salivary gland tumors.Materials and methods: In this retrospective and cross-sectional study, 151 participants, including 42 patients with benign, 42 malignant salivary gland tumors, and 67 healthy subjects, participated. The serum level of vitamin D was measured using an enzyme-linked immunosorbent assay (ELISA).Results: The mean serum level of vitamin D was 42.7 ng/mL in patients with benign tumors, 40 ng/mL in malignant tumors, and 36.7 ng/mL in the control group. There was no significant difference between the mean vitamin D level and vitamin D status in patients with salivary gland tumors and normal controls (P=0.2). There was a significant positive correlation between vitamin D level and age in the control group (P=0.04).Conclusions: The results showed a high prevalence rate of vitamin D deficiency/insufficiency in salivary gland tumors and normal subjects, with no significant difference. Therefore, the serum level of vitamin D might not play a significant role in the pathogenesis of these tumors, similar to many human cancers. However, further prospective studies are recommended focusing on specific tumors and considering other interventional factors.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 130","pages":"273-278"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Necrosis of the Tongue as a Late Complication of Radiotherapy. 作为放疗晚期并发症的舌头坏死。

Iranian Journal of Otorhinolaryngology Pub Date : 2023-09-01 DOI: 10.22038/IJORL.2023.67124.3305

Cristina Aguiar, Paulo Pina, Nuno Medeiros, Mónica Teixeira, Leandro Ribeiro, Pedro Oliveira

{"title":"Necrosis of the Tongue as a Late Complication of Radiotherapy.","authors":"Cristina Aguiar, Paulo Pina, Nuno Medeiros, Mónica Teixeira, Leandro Ribeiro, Pedro Oliveira","doi":"10.22038/IJORL.2023.67124.3305","DOIUrl":"https://doi.org/10.22038/IJORL.2023.67124.3305","url":null,"abstract":"Introduction: Irradiation to treat head and neck cancer, causing chronic tissue damage, is associated with the development of vascular disease. Interest has risen over the effects of radiotherapy on major vessels, due to its high morbidity and mortality rate. However, small-vessel disease has been poorly studied and described.Case report: We present a case of a patient with bilateral necrosis of the anterior third of the tongue, occurring 3 years after chemoradiotherapy treatment for squamous cell carcinoma of the floor of the mouth. Contrast-enhanced CT scan showed multiple areas of stenosis concerning both external carotid arteries and their branches, and total opacification of lingual arteries. Conservative management was performed, with auto-amputation on the fifth day, which allowed healing by secondary intention.Conclusions: Necrosis of the tongue appears as a rare late complication of radiotherapy, possibly due to its acceleration effect on the atherosclerosis process. Following small-vessel disease, one can assume a higher potential risk of major-vessel disease, highlighting the importance of a routine assessment and prophylaxis of thrombotic events.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 130","pages":"285-288"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological Profile. 鼻孢子虫病--流行病学、临床放射学和免疫学概况。

Iranian Journal of Otorhinolaryngology Pub Date : 2023-09-01 DOI: 10.22038/IJORL.2023.68378.3331

Megha Chandran, Rupa Mehta, Nitin M Nagarkar, Anudita Bhargava, Eli Mohapatra, Saroj Kumar Pati

{"title":"Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological Profile.","authors":"Megha Chandran, Rupa Mehta, Nitin M Nagarkar, Anudita Bhargava, Eli Mohapatra, Saroj Kumar Pati","doi":"10.22038/IJORL.2023.68378.3331","DOIUrl":"https://doi.org/10.22038/IJORL.2023.68378.3331","url":null,"abstract":"Introduction: Rhinosporidiosis is an enigmatic disease with many unsolved queries right from taxonomy to treatment. This study has been done to understand the disease characteristics with a peek into the lesser known immunological aspects of it by studying the changes in levels of certain primarily cell-mediated immunity (CMI)-specific cytokines in rhinosporidiosis patients.Materials and methods: A prospective observational study was performed. Detailed epidemiological and clinicoradiological assessment was done along with selected inflammatory and immunological markers. The tests for immunological parameters were done by ELISA and CLIA and data were compiled and analyzed using appropriate statistics.Results: Disease showed male predominance and all patients gave a universal pond bathing history. Majority patients had O+ve blood group. Right side was affected most with nasal obstruction being commonest symptom. Nasal cavity was involved in majority of cases with inferior turbinate and meatus being sites of maximum occurrence and attachment. Nasopharynx, oropharynx were other involved sites. Extra-nasal sites included skin and parotid gland. Endoscopic and CECT findings were similar and confirmed intraoperatively. Tests for inflammatory markers showed no significant change in patients. Immunological markers -IL-6, TNF-beta- levels showed significant increase though no such increase was found with IFN-gamma levels.Conclusion: Rhinosporidiosis has a definite epidemiological and clinical-radiological profile. A clear association with exposure to contaminated water is present which could not be further associated with disease duration or recurrence. The immunological profile needs to be further investigated upon since it remains quite elusive.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 130","pages":"255-262"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-Cov-2 Cycle Threshold Value and Olfactory Dysfunction in COVID-19 Patients. SARS-Cov-2周期阈值与COVID-19患者的嗅觉功能障碍

Iranian Journal of Otorhinolaryngology Pub Date : 2023-09-01 DOI: 10.22038/IJORL.2023.71462.3429

Ali Goljanian Tabrizi, Maliheh Mohseni Ashjerdi, Matin Ghazizadeh, Majid Maleki

{"title":"SARS-Cov-2 Cycle Threshold Value and Olfactory Dysfunction in COVID-19 Patients.","authors":"Ali Goljanian Tabrizi, Maliheh Mohseni Ashjerdi, Matin Ghazizadeh, Majid Maleki","doi":"10.22038/IJORL.2023.71462.3429","DOIUrl":"https://doi.org/10.22038/IJORL.2023.71462.3429","url":null,"abstract":"Introduction: Considering the inconsistent results regarding the association between the severity and duration of olfactory dysfunction (OD), and the viral load in coronavirus disease 2019 (COVID-19) patients, we aimed to conduct this study.Materials and methods: This is a prospective cohort study in which COVID-19 patients were evaluated for the initial cycle threshold value (Ct values) measured by the nasopharyngeal samples along with olfactory function measured by the University of Pennsylvania Smell Identification Test (UPSIT) within 2 months of COVID-19 onset.Results: Among 309 COVID-19 patients who were included in this study, 108 (34.9%), 112 (36.2%) and 89 (28.8%) were normosmic, hyposmic, and anosmic, respectively based on the UPSIT. The severity of COVID-19 and the rate of hospitalization were higher in anosmic patients (p<0.0001, and p<0.0001, respectively). Moreover, significant associations between the initial Ct value and the severity of OD at admission and follow-ups were detected (p<0.0001 and p<0.0001, respectively). Anosmic patients had higher Ct values in comparison with hyposmic (approx. 3-fold) and normosmic (approx. 12-fold) patients. The recovery rate after one- and two-month follow-ups was 47% and 84%, respectively. At the follow-ups, OD-recovered patients significantly had lower Ct values (mean Ct value: 27.79 ± 2 and 28.21 ± 2.08) in comparison with those who have not recovered yet (mean Ct value: 30.19 ± 3.36, and 33.6 ± 3.37) (p<0.0001, and p<0.0001, respectively).Conclusions: Ct value seems to be a significant factor not only in predicting OD severity in COVID-19 patients but also in the OD recovery duration. This finding may be helpful to investigate the underlying mechanisms of OD in COVID-19 patients.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 130","pages":"263-273"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasopharyngeal Branchial Cyst and Thornwaldt Cyst in a Patient with Hearing Loss after Coronavirus Infection. 一名感染冠状病毒后听力丧失的患者的鼻咽支气管囊肿和 Thornwaldt 囊肿。

Iranian Journal of Otorhinolaryngology Pub Date : 2023-09-01 DOI: 10.22038/IJORL.2023.71639.3436

Hosna Zobairy, Shahin Rajaeih, Mersad Mehrnahad, Parisa Modaresi, Ahmad Sofi-Mahmudi

引用次数: 0