Iranian Journal of Otorhinolaryngology最新文献

Nasopharyngeal Solitary Extramedullary Plasmacytoma: A Rare Case and Review of Literature. 鼻咽孤立性髓外浆细胞瘤一例及文献复习。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.88907.3981

Shivangi Patnecha, Rupa Mehta, Siddhartha Nanda, Amit Chowhan

{"title":"Nasopharyngeal Solitary Extramedullary Plasmacytoma: A Rare Case and Review of Literature.","authors":"Shivangi Patnecha, Rupa Mehta, Siddhartha Nanda, Amit Chowhan","doi":"10.22038/ijorl.2025.88907.3981","DOIUrl":"10.22038/ijorl.2025.88907.3981","url":null,"abstract":"Introduction: Solitary extramedullary plasmacytoma (EMP) of the nasopharynx is a rare plasma cell neoplasm, representing a small subset of head and neck malignancies. Its nonspecific symptoms often lead to diagnostic delays.Case report: A 50-year-old female with non-specific progressive nasal obstruction and intermittent epistaxis, underwent complete endoscopic surgical excision using coblation. Post operative histopathology revealed Nasopharyngeal Extramedullary Plasmacytoma. The patient then received adjuvant radiotherapy (Volumetric Modulated Arc Therapy - VMAT), leading to a successful outcome with no recurrence at the one-year follow-up.Conclusion: This case underscores the importance of clinico-histopathological evaluation and a comprehensive, multimodal treatment approach, with nasopharyngeal extramedullary plasmacytoma (EMP) considered as a differential diagnosis in nasopharyngeal masses. Given the potential for progression to multiple myeloma, long-term surveillance is crucial. Increased awareness of this rare entity can facilitate early diagnosis, timely intervention, and improved patient outcomes.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 2","pages":"131-136"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Two Groups of Patients with Benign and Malignant Salivary Gland Tumors. 两组良性和恶性唾液腺肿瘤患者中性粒细胞/淋巴细胞及血小板/淋巴细胞比值的比较

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.89668.4001

Mohammad Hossein Shafieyoun, Nezamoddin Berjis, Afrooz Eshaghian

{"title":"Comparison of the Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Two Groups of Patients with Benign and Malignant Salivary Gland Tumors.","authors":"Mohammad Hossein Shafieyoun, Nezamoddin Berjis, Afrooz Eshaghian","doi":"10.22038/ijorl.2025.89668.4001","DOIUrl":"10.22038/ijorl.2025.89668.4001","url":null,"abstract":"Introduction: The ratio of neutrophils to peripheral lymphocytes is an inflammatory marker, and, based on previous studies, this ratio is associated with poor survival in several cancers. This study was conducted to compare the neutrophils-to-lymphocytes ratio (NLR) and platelets-to-lymphocytes ratio (PLR) in two groups of patients with benign and malignant salivary gland tumors.Materials and methods: This study was cross-sectional, comparing two groups of patients with benign and malignant salivary gland masses. During the last 6 years (from 2018 to 2024), 380 Patients with a definite diagnosis of salivary gland tumors were included in the study, and NLR and PLR data were obtained from pre-operation laboratory exams.Results: NLR and PLR were significantly higher on average than in benign masses (P<0.05). The best cut point was 2.24 for NLR (sensitivity: 78%, specificity: 80%) and 104.35 for PLR (sensitivity: 68%, specificity: 60%).Conclusion: NLR and PLR are easy, practical methods that provide valuable information for diagnosing, assessing severity, and predicting prognosis of various diseases, such as salivary gland masses.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Culture Medium Obtained from Dental Pulp Stem Cells (Conditioned Medium) on Esophageal Squamous Cell Carcinoma Cell Line (KYSE-30). 牙髓干细胞培养培养基（条件培养基）对食管鳞状细胞癌细胞株（KYSE-30）的影响。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.84920.3857

Setare Tavakoli, Akbar Safipour Afshar, Nooshin Mohtasham, Zohre Samiee, Mohammad Amin Yaghoubi, Farnaz Mohajertehran

{"title":"The Effect of Culture Medium Obtained from Dental Pulp Stem Cells (Conditioned Medium) on Esophageal Squamous Cell Carcinoma Cell Line (KYSE-30).","authors":"Setare Tavakoli, Akbar Safipour Afshar, Nooshin Mohtasham, Zohre Samiee, Mohammad Amin Yaghoubi, Farnaz Mohajertehran","doi":"10.22038/ijorl.2025.84920.3857","DOIUrl":"10.22038/ijorl.2025.84920.3857","url":null,"abstract":"Introduction: Esophageal squamous cell carcinoma (ESCC) is the eighth most prevalent cancer worldwide. Head and neck squamous cell carcinoma (HNSCC) represents over 90% of all head and neck cancers, and nearly 40% of patients fail treatment. Therefore, discussion of cancer treatment is essential. In this in vitro study, we examined how conditioned medium from dental pulp stem cells (DPSC-CM) influences the ESCC cell line (KYSE-30).Materials and methods: First, the middle pulp tissue of the wisdom tooth was extracted and, following sterilization, transferred to a cell culture flask containing MEM-α. After completing the culture procedures, conditioned medium (CM) was collected from the fourth passage culture after 72 hours in serum-free medium. The KYSE-30 cells were then treated with the CM for an additional 72 hours, and cell survival was assessed using the MTT assay. Statistical significance was evaluated using one-way ANOVA followed by Tukey's post-hoc test.Results: The results demonstrated that treatment of esophageal cancer cells with conditioned medium (CM) significantly reduced the survival rate of cancer cells compared to control samples. The treatment of KYSE-30 cells with DPSC-CM led to a notable reduction in cell viability (CM group: 51.2 ± 4.1% vs. control group: 72.6 ± 3.3%; P = 0.004).Conclusion: DPSC-CM demonstrates the ability to reduce the proliferation of cancer cells; therefore, this medium can be considered a potential drug (therapeutic) candidate for the treatment of esophageal cancer. However, further studies are required to confirm these results.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 1","pages":"11-17"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasoethmoid Ancient Schwannoma with Bilateral Intracranial Extension: A Case Report with Review of the Literature. 鼻窦炎古神经鞘瘤伴双侧颅内延伸1例并文献复习。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.87978.3952

Ditixa Patel, Nikhil Arora, Ridhima Malik, Sanjay Soni, Harish Taneja, Ravindra Saran, Sabareesh Mylswamy, Divya Singh

{"title":"Nasoethmoid Ancient Schwannoma with Bilateral Intracranial Extension: A Case Report with Review of the Literature.","authors":"Ditixa Patel, Nikhil Arora, Ridhima Malik, Sanjay Soni, Harish Taneja, Ravindra Saran, Sabareesh Mylswamy, Divya Singh","doi":"10.22038/ijorl.2025.87978.3952","DOIUrl":"10.22038/ijorl.2025.87978.3952","url":null,"abstract":"Introduction: Nasoethmoid schwannomas are rare benign tumors of the nasal cavity and paranasal sinuses that arise from local peripheral nerve sheaths. Up to 45% of all schwannomas develop in the head and neck region; however, fewer than 50 cases have been described in the nasoethmoid area in the medical literature. This case underscores the importance of including schwannoma in the differential diagnosis of nasoethmoidal masses with skull-base involvement.Case report: A 60-year-old female presented with diminished sensitivity to smell for 12 months, swelling near left medial canthus and headache for the past 10 months. Nasal endoscopy revealed a smooth encapsulated mass in the anterior roof of nasal cavity between middle turbinate and septum bilaterally. CT and MRI revealed a smooth mass in the roof of nasal cavity having intracranial extra-axial extension. Biopsy displayed features of schwannoma. Patient underwent excision of tumor via combined approach of endoscopy and bifrontal craniotomy. Post-operative histopathology was consistent with features of schwannoma.Conclusion: Nasoethmoidal schwannoma is a benign neoplasm that infrequently exhibits intracranial extension. To date, there have been 17 documented cases in the literature, and this report presents the 18th reported case overall and 6th bilateral case. Because radiographic results are ambiguous, a histological investigation is required for a precise diagnosis. Bifrontal craniotomy combined with endoscopic transnasal excision is the preferred surgical treatment for tumors that extend into the anterior cranial fossa. Long-term clinical follow-up is critical for detecting future recurrences.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 2","pages":"125-130"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Effect of Cryotherapy (Cryoablation) of Posterior Nasal Nerve on the Treatment of Patients with Rhinitis. 鼻后神经冷冻（消融）治疗鼻炎的疗效评价。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.87728.3953

Hossein Eshraghi, Abolfazl Taheri, Ali Bagheri Hagh, Mehdi Raei

{"title":"Evaluation of the Effect of Cryotherapy (Cryoablation) of Posterior Nasal Nerve on the Treatment of Patients with Rhinitis.","authors":"Hossein Eshraghi, Abolfazl Taheri, Ali Bagheri Hagh, Mehdi Raei","doi":"10.22038/ijorl.2025.87728.3953","DOIUrl":"https://doi.org/10.22038/ijorl.2025.87728.3953","url":null,"abstract":"Introduction: Rhinitis is a common condition that is typically treated with medical therapies. However, 10-22% of patients are resistant to these treatments. In our study, the effectiveness of cryotherapy of the posterior nasal nerve (PNN) in treating rhinitis patients who have not responded to conventional medical treatments has been evaluated.Materials and methods: In this single-group interventional study (before/after), 40 patients with rhinitis referred to the ENT clinic of Baqiyatallah Hospital underwent PNN cryotherapy using a new device called Cryo Nose. To collect data, the Total Nasal Symptom Score (TNSS) questionnaire was administered before the intervention and at 1 week, 1 month, 3 months, and 6 months after the intervention.Results: After PNN cryotherapy, the TNSS 12-hour symptom score improved from 9.2 (±2.3) to 6.59 (±2.18) at 1 week later, 3.83 (±1.88) at 1 month later, 2.58 (±1.58) at 3 months later, and 1.98 (±1.47) at 6 months later (P < 0.05). Similar results were noted for the 2-week scores, which improved from 10.38 (±2.53) to 8.35 (±2.32) at 1 week later, 5.95 (±2.09) at 1 month later, 4.27 (±1.61) at 3 months later, and 3.38 (±1.49) at 6 months later (P < 0.05).Conclusions: PNN cryotherapy has been shown to be effective in treating rhinitis during a 6-month follow-up period, with no significant adverse events. The effect of PNN cryotherapy on the symptoms of these patients did not differ between the different types of rhinitis.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 2","pages":"83-91"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Videofluoroscopic Analysis of Postoperative Swallowing Outcomes in Patients with Oral and Oropharyngeal Cancer. 口腔癌和口咽癌患者术后吞咽结果的定量影像透视分析。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.90978.4039

Quang Xuan Ly, Duc Tan Vo, Chau Minh Le Tran, Loan Thi Hong Nguyen

{"title":"Quantitative Videofluoroscopic Analysis of Postoperative Swallowing Outcomes in Patients with Oral and Oropharyngeal Cancer.","authors":"Quang Xuan Ly, Duc Tan Vo, Chau Minh Le Tran, Loan Thi Hong Nguyen","doi":"10.22038/ijorl.2025.90978.4039","DOIUrl":"10.22038/ijorl.2025.90978.4039","url":null,"abstract":"Introduction: Postoperative dysphagia significantly affects the quality of life of patients with oral and oropharyngeal cancer. We aimed to objectively analyze swallowing function in these patients using quantitative biomechanical indices from Videofluoroscopic swallowing studies (VFSS) as well as to identify independent predictors of key swallowing outcomes.Materials and methods: We included 60 patients with postoperative oral and oropharyngeal cancers. VFSS were performed at 3 months (for patients without adjuvant therapy) or 6-7 months (for patients with adjuvant therapy) to assess swallowing safety (Penetration-Aspiration Scale); post-swallowing pharyngeal residue; and biomechanical functions, including pharyngeal transit time (PTT), laryngeal vestibule closure duration, pharyngoesophageal segment opening duration/dimension, and laryngeal elevation. Generalized linear models (GLMs) were used to identify independent predictors.Results: The cohort was predominantly male (78.3%); further, 58.4% of the patients received adjuvant therapy. Thin liquids had the highest penetration and aspiration rates, whereas extremely thick liquids had the lowest rates. The GLM identified sex, adjuvant treatment, and suprahyoid muscle defects as independent predictors of different VFSS parameters. Specifically, adjuvant therapy and sex were associated with a prolonged PTT, while suprahyoid muscle defects were significant predictors of reduced laryngeal elevation.Conclusion: Swallowing impairment remains prevalent after surgery for oral and oropharyngeal cancers. VFSS analysis could highlight specific biomechanical deficits; further, we identified predictors of key swallowing outcomes, including sex, adjuvant treatment, and suprahyoid defects.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 1","pages":"43-53"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FeNO as a Non-Invasive Biomarker of Type 2 Inflammation in Chronic Rhinosinusitis with Nasal Polyps: Correlation with Serum IgE and Eosinophils. FeNO作为慢性鼻窦炎伴鼻息肉2型炎症的非侵入性生物标志物：与血清IgE和嗜酸性粒细胞的相关性

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.88968.3979

Sahar Fereydouni, Farahzad Jabbari-Azad, Mehdi Bakhshaee, Maryam Khoshkhui, Yaser Yadegari, Mojgan Mohammadi

{"title":"FeNO as a Non-Invasive Biomarker of Type 2 Inflammation in Chronic Rhinosinusitis with Nasal Polyps: Correlation with Serum IgE and Eosinophils.","authors":"Sahar Fereydouni, Farahzad Jabbari-Azad, Mehdi Bakhshaee, Maryam Khoshkhui, Yaser Yadegari, Mojgan Mohammadi","doi":"10.22038/ijorl.2025.88968.3979","DOIUrl":"10.22038/ijorl.2025.88968.3979","url":null,"abstract":"Introduction: Chronic rhinosinusitis with nasal polyps is a heterogeneous inflammatory disorder often driven by type 2 inflammation. Identification of non-invasive biomarkers, such as fractional exhaled nitric oxide (FeNO), may support the assessment and personalized management.Materials and methods: In this cross-sectional study, 141 patients with clinically and radiologically confirmed CRSwNP were assessed. FeNO levels, nasal eosinophilia, serum IgE, peripheral blood eosinophil counts, and skin prick test results were evaluated. Disease severity was measured using the SNOT-22 and Lund-Mackay CT scores.Results: FeNO showed a significant correlation with nasal eosinophilia (r = 0.53, p < 0.001), a moderate correlation with serum IgE (r = 0.40, p < 0.001), and a weak correlation with blood eosinophils (r = 0.17, p = 0.047). Serum IgE was significantly associated with both SNOT-22 and Lund-Mackay scores. FeNO did not show significant correlation with symptom severity or radiological extent, suggesting its use as a supportive marker rather than a stand-alone predictor.Conclusion: FeNO may serve as a potential non-invasive marker for type 2 inflammation in CRSwNP, though it may not predict disease severity. Combining FeNO with other markers could improve clinical endotyping and management.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Vitamin D Deficiency on Incidence and Relapse of Benign Paroxysmal Positional Vertigo. 维生素D缺乏对良性阵发性位置性眩晕发病及复发的影响。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2026.90851.4032

Manwinder Singh Walia, Nitika Tuli, Arshaque Hussain, Sandeep Bansal, Ruchika Bhagat

{"title":"Effect of Vitamin D Deficiency on Incidence and Relapse of Benign Paroxysmal Positional Vertigo.","authors":"Manwinder Singh Walia, Nitika Tuli, Arshaque Hussain, Sandeep Bansal, Ruchika Bhagat","doi":"10.22038/ijorl.2026.90851.4032","DOIUrl":"10.22038/ijorl.2026.90851.4032","url":null,"abstract":"Introduction: Benign Paroxysmal Positional Vertigo (BPPV) is a peripheral labyrinth disease and is a prevalent cause of dizziness with a lifetime frequency of roughly 10%. Otoconia found in the otolith organ contain calcium carbonate and protein. Derangement in calcium homeostasis due to vitamin D is implicated in both the onset and recurrence of BPPV, and supplementation could play a role in preventing or alleviating the condition.Materials and methods: This prospective study enrolled a total of 60 patients with posterior semicircular canal BPPV. Subjects were divided into Group A with vitamin D<20ng/ml (45) and Group B with vitamin D>20ng/ml (15). Group A on day 1 received Canal Repositioning Manoeuvre (CRM) and vitamin D supplementation. Group B on day 1 received CRM only. Patients were followed up at 1,2,3, and 6 months and reassessed for vitamin D levels and relapse of BPPV.Results: Out of 60 subjects, 14 showed relapse, 23.3%. Out of 45 subjects in Group A, 13 showed relapse (28.9%). Among 15 patients in Group B, only 1 patient showed relapse (6.7%). Vitamin D levels in the supplementation group normalized before 3 months of follow-up. After 3 months, no relapse was noted in either of the groups. Hence, vitamin D-deficient BPPV patients showed a significantly a higher rate of relapse (p value 0.039).Conclusion: This study demonstrates a high incidence of vitamin D deficiency among patients with BPPV. Also, patients with low vitamin D levels have higher rate of relapse of BPPV, and correction of vitamin D levels leads to a decrease in relapse frequency.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 2","pages":"99-108"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory and Antioxidant Effects of Kaempferia galanga Extract in Acute Bacterial Rhinosinusitis: In Vivo Study on MDA, NF-κB, and CRP. 山奈良姜提取物对急性细菌性鼻窦炎的抗炎和抗氧化作用：体内MDA、NF-κB和CRP的研究

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.90356.4019

Aziza Viquisa Berliana Putri, Paramasari Dirgahayu, Bambangx Purwanto, Soetrisno Soetrisno, Betty Suryawati, Risya Cilmiaty, Hadi Sudrajad

{"title":"Anti-inflammatory and Antioxidant Effects of Kaempferia galanga Extract in Acute Bacterial Rhinosinusitis: In Vivo Study on MDA, NF-κB, and CRP.","authors":"Aziza Viquisa Berliana Putri, Paramasari Dirgahayu, Bambangx Purwanto, Soetrisno Soetrisno, Betty Suryawati, Risya Cilmiaty, Hadi Sudrajad","doi":"10.22038/ijorl.2025.90356.4019","DOIUrl":"10.22038/ijorl.2025.90356.4019","url":null,"abstract":"Introduction: Acute bacterial rhinosinusitis (ABRS) is an inflammation of the paranasal sinuses caused by bacterial infection, primarily involving inflammatory responses and oxidative stress. While antibiotics are the standard treatment, their effectiveness can sometimes be limited. Kaempferia galanga (K. galanga), a medicinal plant known for its anti-inflammatory and antioxidant properties, has shown potential as a therapeutic agent. This study aimed to evaluate the therapeutic efficacy of K. galanga extract in a mouse model of ABRS.Materials and methods: An in vivo experimental study was conducted using Sprague-Dawley rats with induced ABRS. The animals were randomly divided into three treatment groups that received K. galanga extract at doses of 150 mg/kg (KG150), 300 mg/kg (KG300), or 450 mg/kg (KG450) based on body weight. Therapeutic effects were assessed by measuring serum levels of MDA, NF-κB, and CRP.Results: Eighteen rats with ABRS were included in the study. The KG300 group exhibited significantly lower levels of MDA, NF-κB, and CRP compared to the KG150 and KG450 groups (p < 0.05). These findings suggest that the 300 mg/kg dose of K. galanga extract provides optimal therapeutic benefit.Conclusion: K. galanga extract at 300 mg/kg demonstrated the most potent anti-inflammatory and antioxidant effects in a mouse model of ABRS, indicating its potential as an effective alternative or adjunctive therapy.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 1","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Call for Rigorous Clinical Trial: Effect of Intratympanic Dexamethasone on Bell's Palsy. 鼓室内地塞米松治疗贝尔氏麻痹的临床试验。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.85294.3866

Srilakshmi R Rao, Chethana Ramesh, Pranaya Deepika

引用次数: 0