Iranian Journal of Otorhinolaryngology最新文献_第2页

Nasoethmoid Ancient Schwannoma with Bilateral Intracranial Extension: A Case Report with Review of the Literature. 鼻窦炎古神经鞘瘤伴双侧颅内延伸1例并文献复习。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.87978.3952

Ditixa Patel, Nikhil Arora, Ridhima Malik, Sanjay Soni, Harish Taneja, Ravindra Saran, Sabareesh Mylswamy, Divya Singh

{"title":"Nasoethmoid Ancient Schwannoma with Bilateral Intracranial Extension: A Case Report with Review of the Literature.","authors":"Ditixa Patel, Nikhil Arora, Ridhima Malik, Sanjay Soni, Harish Taneja, Ravindra Saran, Sabareesh Mylswamy, Divya Singh","doi":"10.22038/ijorl.2025.87978.3952","DOIUrl":"10.22038/ijorl.2025.87978.3952","url":null,"abstract":"Introduction: Nasoethmoid schwannomas are rare benign tumors of the nasal cavity and paranasal sinuses that arise from local peripheral nerve sheaths. Up to 45% of all schwannomas develop in the head and neck region; however, fewer than 50 cases have been described in the nasoethmoid area in the medical literature. This case underscores the importance of including schwannoma in the differential diagnosis of nasoethmoidal masses with skull-base involvement.Case report: A 60-year-old female presented with diminished sensitivity to smell for 12 months, swelling near left medial canthus and headache for the past 10 months. Nasal endoscopy revealed a smooth encapsulated mass in the anterior roof of nasal cavity between middle turbinate and septum bilaterally. CT and MRI revealed a smooth mass in the roof of nasal cavity having intracranial extra-axial extension. Biopsy displayed features of schwannoma. Patient underwent excision of tumor via combined approach of endoscopy and bifrontal craniotomy. Post-operative histopathology was consistent with features of schwannoma.Conclusion: Nasoethmoidal schwannoma is a benign neoplasm that infrequently exhibits intracranial extension. To date, there have been 17 documented cases in the literature, and this report presents the 18th reported case overall and 6th bilateral case. Because radiographic results are ambiguous, a histological investigation is required for a precise diagnosis. Bifrontal craniotomy combined with endoscopic transnasal excision is the preferred surgical treatment for tumors that extend into the anterior cranial fossa. Long-term clinical follow-up is critical for detecting future recurrences.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 2","pages":"125-130"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Videofluoroscopic Analysis of Postoperative Swallowing Outcomes in Patients with Oral and Oropharyngeal Cancer. 口腔癌和口咽癌患者术后吞咽结果的定量影像透视分析。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.90978.4039

Quang Xuan Ly, Duc Tan Vo, Chau Minh Le Tran, Loan Thi Hong Nguyen

{"title":"Quantitative Videofluoroscopic Analysis of Postoperative Swallowing Outcomes in Patients with Oral and Oropharyngeal Cancer.","authors":"Quang Xuan Ly, Duc Tan Vo, Chau Minh Le Tran, Loan Thi Hong Nguyen","doi":"10.22038/ijorl.2025.90978.4039","DOIUrl":"10.22038/ijorl.2025.90978.4039","url":null,"abstract":"Introduction: Postoperative dysphagia significantly affects the quality of life of patients with oral and oropharyngeal cancer. We aimed to objectively analyze swallowing function in these patients using quantitative biomechanical indices from Videofluoroscopic swallowing studies (VFSS) as well as to identify independent predictors of key swallowing outcomes.Materials and methods: We included 60 patients with postoperative oral and oropharyngeal cancers. VFSS were performed at 3 months (for patients without adjuvant therapy) or 6-7 months (for patients with adjuvant therapy) to assess swallowing safety (Penetration-Aspiration Scale); post-swallowing pharyngeal residue; and biomechanical functions, including pharyngeal transit time (PTT), laryngeal vestibule closure duration, pharyngoesophageal segment opening duration/dimension, and laryngeal elevation. Generalized linear models (GLMs) were used to identify independent predictors.Results: The cohort was predominantly male (78.3%); further, 58.4% of the patients received adjuvant therapy. Thin liquids had the highest penetration and aspiration rates, whereas extremely thick liquids had the lowest rates. The GLM identified sex, adjuvant treatment, and suprahyoid muscle defects as independent predictors of different VFSS parameters. Specifically, adjuvant therapy and sex were associated with a prolonged PTT, while suprahyoid muscle defects were significant predictors of reduced laryngeal elevation.Conclusion: Swallowing impairment remains prevalent after surgery for oral and oropharyngeal cancers. VFSS analysis could highlight specific biomechanical deficits; further, we identified predictors of key swallowing outcomes, including sex, adjuvant treatment, and suprahyoid defects.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 1","pages":"43-53"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Results of Conchomeatoplasty Using Subjective and Objective Parameters in Canal Wall Down Mastoidectomy. 用主客观参数评价椎管下壁乳突切除术中巩膜成形术的效果。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2026.92563.4084

Kamalika P Roy, Santosh Balasaheb Mane, Poonam Subash Khairnar, Mishal Ibji, Devdutt Kotnis

{"title":"Assessment of Results of Conchomeatoplasty Using Subjective and Objective Parameters in Canal Wall Down Mastoidectomy.","authors":"Kamalika P Roy, Santosh Balasaheb Mane, Poonam Subash Khairnar, Mishal Ibji, Devdutt Kotnis","doi":"10.22038/ijorl.2026.92563.4084","DOIUrl":"https://doi.org/10.22038/ijorl.2026.92563.4084","url":null,"abstract":"Introduction: Conchomeatoplasty is an important step of canal wall down mastoidectomy performed to promote dry, self-cleaning ear. Various techniques of conchomeatoplasty have been described and each has documented good results. However, a consistent and reliable method of assessing the outcome has not been explored. This study focuses on assessing the results of radial incision technique of conchomeatoplasty advocated by us using both subjective and objective parameters.Materials and methods: A prospective observational study was designed to assess 55 patients of canal wall down mastoidectomy with conchomeatoplasty. These patients were evaluated for the ear canal size at 3 and 6 months post operatively. A modified chronic ear survey questionnaire where patients' activity restriction, symptoms and medical resource utilization subscale were noted for subjective outcome. Objective evaluation analysed otoscopic visibility of superior limit, floor of mastoid bowl and sino-dural angle.Results: The mean size of external auditory meatus at 3 and 6 months were 9.861 mm and 10.145 mm respectively. At 6 months follow up, there was a significant association between visibility of landmarks and size of external auditory canal as well as with the necessity of water restriction. However, there was no association of size of ear canal with interference with social activity, frequency or quantity of ear discharge and frequency of physician's visit.Conclusion: Using subjective and objective parameters facilitates a consistent and measurable assessment of the outcome of conchomeatoplasty rather than considering the size of meatoplasty alone. The radial incision technique advocated in the present study gives good postoperative results.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 4","pages":"223-229"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FeNO as a Non-Invasive Biomarker of Type 2 Inflammation in Chronic Rhinosinusitis with Nasal Polyps: Correlation with Serum IgE and Eosinophils. FeNO作为慢性鼻窦炎伴鼻息肉2型炎症的非侵入性生物标志物：与血清IgE和嗜酸性粒细胞的相关性

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.88968.3979

Sahar Fereydouni, Farahzad Jabbari-Azad, Mehdi Bakhshaee, Maryam Khoshkhui, Yaser Yadegari, Mojgan Mohammadi

{"title":"FeNO as a Non-Invasive Biomarker of Type 2 Inflammation in Chronic Rhinosinusitis with Nasal Polyps: Correlation with Serum IgE and Eosinophils.","authors":"Sahar Fereydouni, Farahzad Jabbari-Azad, Mehdi Bakhshaee, Maryam Khoshkhui, Yaser Yadegari, Mojgan Mohammadi","doi":"10.22038/ijorl.2025.88968.3979","DOIUrl":"10.22038/ijorl.2025.88968.3979","url":null,"abstract":"Introduction: Chronic rhinosinusitis with nasal polyps is a heterogeneous inflammatory disorder often driven by type 2 inflammation. Identification of non-invasive biomarkers, such as fractional exhaled nitric oxide (FeNO), may support the assessment and personalized management.Materials and methods: In this cross-sectional study, 141 patients with clinically and radiologically confirmed CRSwNP were assessed. FeNO levels, nasal eosinophilia, serum IgE, peripheral blood eosinophil counts, and skin prick test results were evaluated. Disease severity was measured using the SNOT-22 and Lund-Mackay CT scores.Results: FeNO showed a significant correlation with nasal eosinophilia (r = 0.53, p < 0.001), a moderate correlation with serum IgE (r = 0.40, p < 0.001), and a weak correlation with blood eosinophils (r = 0.17, p = 0.047). Serum IgE was significantly associated with both SNOT-22 and Lund-Mackay scores. FeNO did not show significant correlation with symptom severity or radiological extent, suggesting its use as a supportive marker rather than a stand-alone predictor.Conclusion: FeNO may serve as a potential non-invasive marker for type 2 inflammation in CRSwNP, though it may not predict disease severity. Combining FeNO with other markers could improve clinical endotyping and management.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjuvant Treatment Strategies for Acute Invasive Fungal Rhinosinusitis: An in Vitro Evaluation. 急性侵袭性真菌性鼻窦炎的辅助治疗策略：体外评价。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2026.95600.4151

Ermia Mousavi Mohammadi, Mehdi Bakhshaee, Amir Ashkan Mousavi Mohammadi, Hossein Zarrinfar, Imaneh Roshanzamir, Abolfazl Zanghaei, Sahar Nikrooz

{"title":"Adjuvant Treatment Strategies for Acute Invasive Fungal Rhinosinusitis: An in Vitro Evaluation.","authors":"Ermia Mousavi Mohammadi, Mehdi Bakhshaee, Amir Ashkan Mousavi Mohammadi, Hossein Zarrinfar, Imaneh Roshanzamir, Abolfazl Zanghaei, Sahar Nikrooz","doi":"10.22038/ijorl.2026.95600.4151","DOIUrl":"https://doi.org/10.22038/ijorl.2026.95600.4151","url":null,"abstract":"Introduction: Acute invasive fungal rhinosinusitis (AIFR) is a severe condition with high morbidity and mortality, despite established management protocols. Adjuvant therapies may improve disease control. This study aimed to investigate the in vitro antifungal effects of acetic acid (AA) and hydrogen peroxide (HP) on fungi implicated in AIFR.Materials and methods: Sinonasal tissue biopsies obtained during endoscopic sinus surgery (ESS) from patients with AIFR, fungal ball, or allergic fungal rhinosinusitis (AFRS) were collected. Biopsies were exposed to 0.25% AA or 1.5% HP for 10 minutes and subsequently cultured on Sabouraud dextrose agar. Untreated tissue portions served as controls. Fungal growth was assessed and identified using macroscopic and microscopic characteristics.Results: Of 48 collected samples, 10 did not grow in any culture medium and were excluded. Among the remaining 38 samples, AA inhibited fungal growth in 7 samples (18.5%), and HP inhibited growth in 3 samples (8%). The majority of isolates were Aspergillus species (87%), with Mucorales representing 5.26%. Two samples demonstrated growth only in AA- or HP-supplemented media, with no growth in standard media. Statistical analysis showed no significant differences in growth across the three media.Conclusion: Although AA and HP exhibited some antifungal activity in vitro, their effects on clinically relevant fungal pathogens, particularly Aspergillus and Mucorales, were limited. Therefore, these compounds may not be suitable as standalone adjuvant therapies for AIFR. Further research is required to explore alternative or combinatorial adjuvant approaches.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 4","pages":"241-246"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Hyperacusis in Patients with Tinnitus. 耳鸣患者听觉亢进的研究。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2026.94349.4125

Javaneh Jahanshahi, Roya Najafi Vosough, Azade Mohammad-Amini, Seyede Faranak Emami

{"title":"Investigation of Hyperacusis in Patients with Tinnitus.","authors":"Javaneh Jahanshahi, Roya Najafi Vosough, Azade Mohammad-Amini, Seyede Faranak Emami","doi":"10.22038/ijorl.2026.94349.4125","DOIUrl":"10.22038/ijorl.2026.94349.4125","url":null,"abstract":"Introduction: Hyperacusis is defined as a decreased tolerance to common everyday sounds. A numer of the sufferers have tinnitus. Therefore, this study aimed to compare the hyperacusis scores between tinnitus sufferers and people without tinnitus.Materials and methods: This case-control study had 80 participants (the case group or hyperacusis-tinnitus sufferers =40 and the control group or normal subjects=40). Data were collected using tympanometry, pure tone audiometry, word-in-noise perception test, loudness discomfortable (LDL) test and the Persian-version of the Khalfa hyperacusis questionnaire (HQ). Data analysis was done using independent samples t-test, Mann-Whitney, Chi-square and Kruskal-Wallis tests. The significance level of less than 0.05 was considered.Results: In hyperacusis-tinnitus sufferers, the mean scores of hyperacusis (24.17±6.83) were meaningly (p=0.00) more than of normal subjects (8.38±9.16). The causal relations were found between them in terms of hearing loss (P=0.00). The differences among the two groups in terms of hyperacusis scores were significant, in patients over 40 years of age (p=0.01), but not in those under 40 years of age (p=0.06). In hyperacusis-tinnitus sufferers, no causal relationships were found among hyperacusis scores with sex, degree of hearing loss and its type.Conclusion: Hyperacusis is more common in old patients combined tinnitus and hearing loss. Gender, severity and nature of hearing loss are not related to the grade of hyperacusis. A common mechanism of central auditory processing disorder is related to tinnitus and hyperacusis, which can them to occur concomitantly. The complete and careful evaluation of patients with tinnitus and hyperacusis is essential.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 3","pages":"171-178"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Vitamin D Deficiency on Incidence and Relapse of Benign Paroxysmal Positional Vertigo. 维生素D缺乏对良性阵发性位置性眩晕发病及复发的影响。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2026.90851.4032

Manwinder Singh Walia, Nitika Tuli, Arshaque Hussain, Sandeep Bansal, Ruchika Bhagat

{"title":"Effect of Vitamin D Deficiency on Incidence and Relapse of Benign Paroxysmal Positional Vertigo.","authors":"Manwinder Singh Walia, Nitika Tuli, Arshaque Hussain, Sandeep Bansal, Ruchika Bhagat","doi":"10.22038/ijorl.2026.90851.4032","DOIUrl":"10.22038/ijorl.2026.90851.4032","url":null,"abstract":"Introduction: Benign Paroxysmal Positional Vertigo (BPPV) is a peripheral labyrinth disease and is a prevalent cause of dizziness with a lifetime frequency of roughly 10%. Otoconia found in the otolith organ contain calcium carbonate and protein. Derangement in calcium homeostasis due to vitamin D is implicated in both the onset and recurrence of BPPV, and supplementation could play a role in preventing or alleviating the condition.Materials and methods: This prospective study enrolled a total of 60 patients with posterior semicircular canal BPPV. Subjects were divided into Group A with vitamin D<20ng/ml (45) and Group B with vitamin D>20ng/ml (15). Group A on day 1 received Canal Repositioning Manoeuvre (CRM) and vitamin D supplementation. Group B on day 1 received CRM only. Patients were followed up at 1,2,3, and 6 months and reassessed for vitamin D levels and relapse of BPPV.Results: Out of 60 subjects, 14 showed relapse, 23.3%. Out of 45 subjects in Group A, 13 showed relapse (28.9%). Among 15 patients in Group B, only 1 patient showed relapse (6.7%). Vitamin D levels in the supplementation group normalized before 3 months of follow-up. After 3 months, no relapse was noted in either of the groups. Hence, vitamin D-deficient BPPV patients showed a significantly a higher rate of relapse (p value 0.039).Conclusion: This study demonstrates a high incidence of vitamin D deficiency among patients with BPPV. Also, patients with low vitamin D levels have higher rate of relapse of BPPV, and correction of vitamin D levels leads to a decrease in relapse frequency.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 2","pages":"99-108"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory and Antioxidant Effects of Kaempferia galanga Extract in Acute Bacterial Rhinosinusitis: In Vivo Study on MDA, NF-κB, and CRP. 山奈良姜提取物对急性细菌性鼻窦炎的抗炎和抗氧化作用：体内MDA、NF-κB和CRP的研究

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.90356.4019

Aziza Viquisa Berliana Putri, Paramasari Dirgahayu, Bambangx Purwanto, Soetrisno Soetrisno, Betty Suryawati, Risya Cilmiaty, Hadi Sudrajad

{"title":"Anti-inflammatory and Antioxidant Effects of Kaempferia galanga Extract in Acute Bacterial Rhinosinusitis: In Vivo Study on MDA, NF-κB, and CRP.","authors":"Aziza Viquisa Berliana Putri, Paramasari Dirgahayu, Bambangx Purwanto, Soetrisno Soetrisno, Betty Suryawati, Risya Cilmiaty, Hadi Sudrajad","doi":"10.22038/ijorl.2025.90356.4019","DOIUrl":"10.22038/ijorl.2025.90356.4019","url":null,"abstract":"Introduction: Acute bacterial rhinosinusitis (ABRS) is an inflammation of the paranasal sinuses caused by bacterial infection, primarily involving inflammatory responses and oxidative stress. While antibiotics are the standard treatment, their effectiveness can sometimes be limited. Kaempferia galanga (K. galanga), a medicinal plant known for its anti-inflammatory and antioxidant properties, has shown potential as a therapeutic agent. This study aimed to evaluate the therapeutic efficacy of K. galanga extract in a mouse model of ABRS.Materials and methods: An in vivo experimental study was conducted using Sprague-Dawley rats with induced ABRS. The animals were randomly divided into three treatment groups that received K. galanga extract at doses of 150 mg/kg (KG150), 300 mg/kg (KG300), or 450 mg/kg (KG450) based on body weight. Therapeutic effects were assessed by measuring serum levels of MDA, NF-κB, and CRP.Results: Eighteen rats with ABRS were included in the study. The KG300 group exhibited significantly lower levels of MDA, NF-κB, and CRP compared to the KG150 and KG450 groups (p < 0.05). These findings suggest that the 300 mg/kg dose of K. galanga extract provides optimal therapeutic benefit.Conclusion: K. galanga extract at 300 mg/kg demonstrated the most potent anti-inflammatory and antioxidant effects in a mouse model of ABRS, indicating its potential as an effective alternative or adjunctive therapy.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 1","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Call for Rigorous Clinical Trial: Effect of Intratympanic Dexamethasone on Bell's Palsy. 鼓室内地塞米松治疗贝尔氏麻痹的临床试验。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2025.85294.3866

Srilakshmi R Rao, Chethana Ramesh, Pranaya Deepika

引用次数: 0

Effects of Curcumin in Workers with Noise-Induced Hearing Loss: Preliminary Report. 姜黄素对噪声性听力损失工人的影响：初步报告。

Iranian Journal of Otorhinolaryngology Pub Date : 2026-01-01 DOI: 10.22038/ijorl.2026.89875.4010

Rizky Amalia, Tengku-Siti-Hajar Haryuna, Adriztina Indri, Yuliani Mardiati Lubis, Adlin Adnan, Delfitri Munir, Taufik Ashar, Khalisanni Khalid

{"title":"Effects of Curcumin in Workers with Noise-Induced Hearing Loss: Preliminary Report.","authors":"Rizky Amalia, Tengku-Siti-Hajar Haryuna, Adriztina Indri, Yuliani Mardiati Lubis, Adlin Adnan, Delfitri Munir, Taufik Ashar, Khalisanni Khalid","doi":"10.22038/ijorl.2026.89875.4010","DOIUrl":"10.22038/ijorl.2026.89875.4010","url":null,"abstract":"Introduction: Prolonged loud noise exposure causes sensorineural hearing loss through cochlear oxidative stress, requiring heat shock protein 70 (HSP70) for protection. Curcumin boosts antioxidant expression and safeguards the cochlea. Pure tone audiometry (PTA) measures the type of hearing loss and otoacoustic emission (OAE) detects early auditory issues. This study evaluated the impact of Curcumin on noise-exposed workers via PTA, OAE, and HSP70.Materials and methods: This preliminary study included 54 noise-exposed workers with hearing thresholds ≥26 dB and SNR values <6 dB. Participants were randomized into three noise-exposed groups: placebo (positive control), 500 mg Curcumin, or 1,000 mg Curcumin for 4 weeks. A negative control group of 18 non-exposed workers with normal hearing who received no treatment, served as an external reference only. HSP70 levels, PTA, and OAE were measured before and after intervention in all groups.Results: PTA showed a significant worsening of hearing threshold in the positive control group (p=0.001), significant improvement in Curcumin 500 mg group (p=0.046), in the Curcumin 1,000 mg (p=0.059). OAE revealed substantial worsening of SNR in the positive control group (p<0.001) and significant increase in the Curcumin 500 mg (p<0.05) at 4, 7, 8, and 9 kHz, and in the 1,000 mg groups (p<0.05) at 5, 8, and 9 kHz. HSP70 levels significantly increased in the positive control group (p=0.021), both Curcumin groups showed a non-significant increase.Conclusion: Curcumin was associated with improved hearing thresholds and favorable SNR changes in noise-exposed workers. Changes in HSP70 levels were minimal and not statistically significant in the curcumin groups.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 3","pages":"159-169"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0