Iranian Journal of Otorhinolaryngology最新文献

{"title":"Can Epirubicin Be Used in Laryngology Practice Like Mitomycin? An Experimental and Pioneering Study.","authors":"Erdem Koroglu, Selahattin Genc, Serdar Baser, Ferit Bayakır, Ahmet Tugrul Eruyar, Busra Yaprak Bayrak","doi":"10.22038/ijorl.2025.87024.3938","DOIUrl":"10.22038/ijorl.2025.87024.3938","url":null,"abstract":"<p><strong>Introduction: </strong>Epirubicin and mitomycin-C share similar mechanisms of action, with both exhibiting antiproliferative effects by inhibiting DNA and protein synthesis. While the efficacy of mitomycin-C in laryngology is well established, this study aims to investigate whether epirubicin can produce comparable clinical outcomes in this field.</p><p><strong>Materials and methods: </strong>Ten rabbits were included in this experimental study. A thermal injury was created at the posterior commissure using a conchal probe. Following the injury, one group was treated with mitomycin-C, while the other received epirubicin. After a six-week post-treatment period, the rabbits were euthanized, and both macroscopic and microscopic evaluations were performed to assess stenosis, scarring, granulation tissue, necrosis, and ulceration. Two pathologists, blinded to the treatment groups, independently examined the histological samples.</p><p><strong>Results: </strong>Macroscopically, no significant differences were observed between the two groups in terms of scarring, synechiae, or granulation tissue formation at the posterior commissure. However, the mitomycin-C group demonstrated a relatively milder tissue response. Microscopic analysis revealed grade 3 collagen deposition in one rabbit and grade 1 in two rabbits from the epirubicin group. In comparison, the mitomycin-C group showed grade 1 deposition in two rabbits and grade 2 in another two. The average fibroblast count was 83.3 in the epirubicin group versus 59 in the mitomycin-C group.</p><p><strong>Conclusions: </strong>Although this pioneering study does not provide conclusive evidence that epirubicin is as effective as or superior to mitomycin-C in laryngology, it highlights epirubicin's potential as a promising candidate for further investigation in the treatment of laryngeal conditions.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"37 5","pages":"247-252"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Coenzyme Q10 on Tinnitus Severity and Sleep Quality in Patients with Presbycusis.","authors":"Rohollah Abbasi, Faranak Emami, Saeid Atighechi, Zahra Sadeghi","doi":"10.22038/ijorl.2024.79602.3681","DOIUrl":"10.22038/ijorl.2024.79602.3681","url":null,"abstract":"<p><strong>Introduction: </strong>Tinnitus is one of the symptoms of presbycusis that affects patients' sleep and social life. This study aimed to determine the effect of coenzyme Q10 (CoQ10) on treating tinnitus due to presbycusis.</p><p><strong>Materials and methods: </strong>In this double-blind, randomized clinical trial, 50 patients with tinnitus due to presbycusis were randomly divided into groups A and B, with 25 patients in each group. In addition to routine treatments, group A received 100 mg of CoQ10 daily, while group B received a placebo. Both groups were evaluated for tinnitus severity, loudness of tinnitus, quality of life, and sleep disturbance before and 6 weeks after starting the treatment.</p><p><strong>Results: </strong>In the intervention and control groups, the mean changes in score compared to before the treatment were as follows: quality of life (3.1 ± 1.67) and (1.28 ± 0.76) (P = 0.298), sleep disorder (-7.60 ± 1.38) and (-1.0 ± 8.55) (P<0.001), tinnitus disability (-17.2 ± 52.93) and (-4.56 ± 1.37) (P<0.001), tinnitus loudness of right ear (-1.68 ± 0.41) and (-0.95 ± 0.23) (P=0.11) and left ear (-2.2 ± 0.35) and (-0.54 ± 0.21) (P<0.001).</p><p><strong>Conclusion: </strong>This study indicated that adding CoQ10 to the routine regimen for patients with tinnitus due to presbycusis significantly decreases tinnitus disability, improves sleep disturbance, and reduces tinnitus loudness. However, more studies should be conducted in this regard.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"37 1","pages":"33-39"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Role of Inflammatory Markers in Predicting Central Lymph Node Metastasis in Papillary Thyroid Carcinoma.","authors":"Ebrahim Farashi, Sajjad Ranjbar, Sahand Eslami, Nikzad Shahidi, Seyed Ziaeddin Rasihashemi","doi":"10.22038/ijorl.2025.84332.3840","DOIUrl":"10.22038/ijorl.2025.84332.3840","url":null,"abstract":"<p><strong>Introduction: </strong>The current study sought to assess the predictive value of inflammatory markers, namely the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR), in relation to central lymph node metastasis (CLNM) in patients with papillary thyroid carcinoma (PTC).</p><p><strong>Materials and methods: </strong>A total of 79 participants with confirmed PTC diagnosis following surgery were included in the study. Demographic data, clinical characteristics, and laboratory variables were collected. CLNM was evaluated based on pathological findings. NLR and PLR were calculated to assess their associations with clinicopathological features and metastasis.</p><p><strong>Results: </strong>The study included 26 males (25.9%) and 53 females (74.1%), with a mean age of 42.26 years (range 15-74). Significant findings included a higher incidence of CLNM in males (<i>p</i>=0.047) and larger tumor sizes in patients with CLNM (<i>p</i>=0.047). Tumor multifocality was also more common in the CLNM group (62.5% vs. 28.9%, <i>p</i>=0.003). Although no significant relationship was found between the inflammatory markers NLR, PLR, and CLNM, a meaningful association was observed between PLR and age in patients with CLNM (<i>r</i>= 0.414, <i>p</i>=0.011).</p><p><strong>Conclusion: </strong>This study demonstrates significant associations between clinicopathological features and CLNM in PTC. Male gender, larger tumor size, and multifocality correlated with higher CLNM rates. While inflammatory markers such as NLR and PLR did not show significant differences, PLR's positive correlation with age in CLNM patients suggests potential prognostic value, warranting further investigation.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"37 3","pages":"135-141"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Oral Preoperative Clonidine with Infusion of Intraoperative Labetalol on Bleeding during Tympanoplasty Surgery.","authors":"Mohamad Reza Afzalzadeh, Mostafa Mahdavi, Saleheh Asghari, Maryam Emadzadeh","doi":"10.22038/ijorl.2025.78101.3626","DOIUrl":"10.22038/ijorl.2025.78101.3626","url":null,"abstract":"<p><strong>Introduction: </strong>Surgical bleeding is one of the most critical complications in various surgical procedures. In middle ear surgery, managing bleeding is a significant challenge for anesthesiologists because even minor bleeding can obstruct the surgeon's vision and prolong the surgery. Our objective is to compare the impact of preoperative oral clonidine versus labetalol infusion on bleeding volume during tympanoplasty surgery.</p><p><strong>Materials and methods: </strong>In this double-blind randomized controlled trial, tympanoplasty candidates were randomly assigned to three groups: the clonidine group (received 300 micrograms of clonidine tablets one hour before surgery with normal saline infusion during the operation), the control group (given a placebo tablet one hour before surgery with normal saline infusion during surgery), and the labetalol group (administered a placebo tablet one hour before surgery with labetalol infusion at a rate of 0.2 mg/kg of body weight per hour during surgery). We then evaluated the extent of intraoperative bleeding, systolic and diastolic blood pressure, mean arterial pressure, and heart rate at various time points until the end of the surgery.</p><p><strong>Results: </strong>Clonidine and labetalol were effective in reducing intraoperative bleeding compared to the control group. Grade 2 bleeding (minimal bleeding requiring intermittent suction) was the highest grade observed across all three groups and was consistently noted in all patients. Clonidine demonstrated greater efficiency in reducing systolic and diastolic blood pressure, mean arterial pressure, and heart rate compared to both labetalol and the control group.</p><p><strong>Conclusion: </strong>Premedication with clonidine or labetalol is associated with reduced intraoperative bleeding, improved surgical field visibility, and shorter duration of tympanoplasty procedures. This may potentially lead to increased satisfaction and success rates of the operation.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"37 3","pages":"105-113"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kikuchi-Fujimoto Disease: A Rare Condition Mimicking Sepsis.","authors":"Sethu Thakachy Subha, Naseeha Roslan Ainur, Mohd Ali Razana","doi":"10.22038/ijorl.2025.82006.3754","DOIUrl":"10.22038/ijorl.2025.82006.3754","url":null,"abstract":"<p><strong>Introduction: </strong>Kikuchi-Fujimoto disease is a self-limited disease which is also known as histiocytic necrotizing lymphadenitis. The Kikuchi-Fujimoto disease is a rare cause of cervical lymphadenopathy, with or without systemic signs, such as fever, leukopenia, and skin rashes.</p><p><strong>Case report: </strong>We presented a case of Kikuchi-Fujimoto disease in a 29-year-old female mimicking sepsis after a COVID-19 infection. Clinical examination revealed stable vitals and multiple diffuse non-tender bilateral cervical and axillary lymph adenopathy with hepatosplenomegaly. The patient's blood parameters showed leukopenia, raised erythrocyte sedimentation rate, lactate dehydrogenase, microcytic hypochromic anemia with normal renal and liver function tests. The patient was treated with broad spectrum intravenous antibiotics and subcutaneous neupogen with a clinical suspicion of sepsis. The patient then underwent a CT scan which validated the clinical findings. Although the fever subsided, a persistent cervical lymphadenopathy was observed and the biopsy confirmed it to be necrotising lymph adenitis secondary to Kikuchi-Fujimoto disease. This patient has been regularly monitored and has shown resolution of cervical lymphadenopathy.</p><p><strong>Conclusion: </strong>Clinicians should suspect Kikuchi-Fujimoto disease when patients present with persistent cervical lymphadenopathy unresponsive to initial medical treatment. Lymph node biopsy should be undertaken to rule out Kikuchi-Fujimoto disease and prevent these patients from extensive diagnostic procedures and inappropriate treatment modalities.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"37 3","pages":"161-164"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Transcanal Type 1 Tympanoplasty with Cartilage Perichondrium Graft; A Prospective Study.","authors":"Parth Makwana, Viral Prajapati, Vivek Makadiya","doi":"10.22038/ijorl.2025.83887.3826","DOIUrl":"10.22038/ijorl.2025.83887.3826","url":null,"abstract":"<p><strong>Introduction: </strong>Recently use of endoscopes for ear surgeries is being popular among the surgeons as it gives a wide view of the middle ear. Also, tympanoplasty by transcanal approach can be done as a day care procedure and so it reduces the cost of hospitalization. The study was aimed to evaluate the results of type 1 tympanoplasty done by endoscopic transcanal approach with cartilage perichondrium graft, in relation to successful graft take-up rate and improvement in hearing.</p><p><strong>Materials and methods: </strong>Total 50 patients were included in the study and all of them underwent type 1 tympanoplasty by endoscopic transcanal approach. Tragal cartilage with its attached perichondrium on one side facing laterally was placed as graft lateral to handle of malleus with v shaped notch at 12 o clock by underlay technique in all the cases. Patients were called for regular follow-up, and they were observed for successful graft take-up and improvement in hearing at 3 months after procedure.</p><p><strong>Results: </strong>Out of 50 cases complete closure was achieved in 46 cases which makes a success rate of 92%. The average improvement in hearing of 15.3 dB was noted.</p><p><strong>Conclusion: </strong>Endoscopic Transcanal approach with cartilage-perichondrium graft for tympanoplasty (type 1) is effective in terms of successful graft take-up rate and improvement in hearing, very cost effective, faster in terms of surgical time, and has less postoperative morbidity so gives better quality of life to the patient.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"37 5","pages":"261-266"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Otoscleroma of the Middle Ear and Mastoid Cavity with Facial Palsy: A Case Report.","authors":"Ahmed Galal, Ahmed Abdelbaki, Hanan Tayel, Hesham Mustafa Abdel-Fattah","doi":"10.22038/ijorl.2024.79380.3675","DOIUrl":"10.22038/ijorl.2024.79380.3675","url":null,"abstract":"<p><strong>Introduction: </strong>Scleroma is a chronic, specific granulomatous disease that affects the head and neck mucosa. Its common sites are the nose and larynx; however, it might affect other areas. One of the rare sites to be affected is the middle ear and mastoid cavity, for which the term otoscleroma was coined. We present such a rare case in this report.</p><p><strong>Case report: </strong>A 47-year-old patient with a history of both old laryngoscleroma and recent Rhinoscleroma. He presented with symptoms of ear discharge and facial palsy. Examination revealed complete facial nerve palsy and an external auditory canal polyp. A decision was made to perform subtotal petrosectomy with facial nerve decompression and maximum debulking to be sent for histopathology. The result came typical of otoscleroma.</p><p><strong>Conclusion: </strong>Otoscleroma is a fairly rare occurrence. It might be primary, with no evidence of Scleroma in other sites or following rhino and/or laryngoscleroma. It might be unilateral or bilateral. It might mimic the clinical picture of chronic suppurative otitis media and its complications. Tympano-mastoidectomy is recommended to stop the discharge, obtain a proper biopsy and decompress the facial nerve if needed. Otoscleroma should be suspected in the case of previous Scleroma in other sites, and otitis media or complications like manifestations.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"37 1","pages":"51-55"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fenestration and Bifurcation of the Internal Jugular Vein; Surprises During Head and Neck Surgery.","authors":"Vibha Singh, Arijit Jotdar, Annanya Soni, Rudra Prakash, Kushal Singh","doi":"10.22038/ijorl.2025.83514.3810","DOIUrl":"10.22038/ijorl.2025.83514.3810","url":null,"abstract":"<p><strong>Introduction: </strong>The internal jugular vein (IJV) is one of the major vessels in the neck and serves as an important landmark for surgeons during head and neck surgery. Anomalies of the IJV are rare and seldom encountered by the surgeons. However, a comprehensive knowledge of these variations is essential for better surgical dissection and to prevent intra-operative mishaps. The variations can be in the forms of bifurcation, trifurcation, duplication, fenestration and posterior tributaries of the IJV. Here we describe three cases of bifurcation and fenestration of the IJV that we encountered in our surgical practice.</p><p><strong>Case report: </strong>In the first patient, we found an empty fenestration of the right internal jugular vein during a selective neck dissection for tongue carcinoma. The spinal accessory nerve was passing lateral to the IJV above the level of the fenestration. The second patient was operated for a left vagal schwannoma in the neck. During the surgery, we found a bifurcation of the left IJV, and the two tributaries fused just above the left omohyoid muscle. The third patient, a sixty-year-old lady also had a bifurcation of the left IJV. It was found during a modified radical neck dissection for carcinoma ex pleomorphic adenoma of the left parotid gland.</p><p><strong>Conclusion: </strong>An in-depth knowledge of the anomalies of the internal jugular vein and meticulous evaluation of the pre-operative imaging may help the surgeons in preventing any intra-operative catastrophe during head and neck surgery.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"37 2","pages":"99-103"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internal Jugular Vein Duplication: A series of Seven Cases and Review of Literature.","authors":"Indu Shukla, Ashish Agarwal, Rimsha Changanath Kader","doi":"10.22038/ijorl.2024.82759.3789","DOIUrl":"10.22038/ijorl.2024.82759.3789","url":null,"abstract":"<p><strong>Introduction: </strong>Internal Jugular Vein (IJV) is an important landmark for Head and Neck surgeons during oncological clearance of disease from neck and microvascular reconstruction as well as for the intensivist during central line insertion. Detailed knowledge of the IJV anatomy and its variations is important to avert any catastrophic complications during surgery.</p><p><strong>Materials and methods: </strong>Data of 350 patients was recorded prospectively and analysed over a period of two years and presence of IJV duplication was documented as percentages<b>.</b></p><p><strong>Results: </strong>A total of 350 patients with diagnosed oral cavity carcinoma were included who underwent neck dissection out of which seven patients were identified with Internal Jugular Vein duplication making it an institutional clinical prevalence of around 2%.</p><p><strong>Conclusion: </strong>IJV duplication is inadvertently found intra operatively on maximum number of occasions therefore to avoid the risk of iatrogenic injury and undesired complications, preoperative imaging should be carefully assessed while planning the patient for surgery.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"37 2","pages":"91-94"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Observational Study on the Accuracy of Transcutaneous Laryngeal Ultrasonography in Assessing Vocal Cord Mobility before and after Thyroid Surgery.","authors":"Harjinder Singh, Thirugnanasambandam Nelson, Kamal Kataria, Ankita Agarwal, Uttam Kumar Thakur, Arvind Kairo, Hitesh Verma, Shuchita Singh Pachaury, Amarinder Singh Malhi, Yashwant Rathore, Yashdeep Gupta, Shivam Pandey, Rajesh Khadgawat, Shipra Agarwal, Sunil Chumber, Anita Dhar","doi":"10.22038/ijorl.2025.86965.3949","DOIUrl":"10.22038/ijorl.2025.86965.3949","url":null,"abstract":"<p><strong>Introduction: </strong>Recurrent Laryngeal Nerve (RLN) injury remains one of the significant complications associated with thyroidectomy, occurring in approximately 1% to 9% of cases. Vocal Cord (VC) function is typically assessed before surgery using laryngoscopy. However, Transcutaneous Laryngeal Ultrasonography (TLUS) has become a non-invasive alternative for evaluating VC mobility. This study was performed to compare the diagnostic accuracy of TLUS with traditional laryngoscopy in assessing vocal cord function in patients undergoing thyroid surgery.</p><p><strong>Materials and methods: </strong>A total of 105 patients undergoing hemi- or total thyroidectomy were enrolled in a prospective observational study at a tertiary healthcare facility from October 2022 to June 2024. TLUS was conducted by endocrine surgeons using a Mindray UGW 11 device. VC mobility was categorised as usual (spontaneous, rhythmic, symmetrical movement) or unilateral VC paralysis (asymmetrical or absent movement on the affected side).</p><p><strong>Results: </strong>In the preoperative setting, TLUS achieved 100% sensitivity, Positive Predictive Value (PPV), and overall diagnostic accuracy. Postoperatively, it maintained a high sensitivity of 99.02%, with specificity reaching 100% and an area under the curve (AUC) of 0.99. The PPV remained at 100%, while the Negative Predictive Value (NPV) was 75%, and the diagnostic accuracy declined slightly to 99.05%. These findings highlight TLUS as a reliable, economical, and patient-friendly modality for evaluating vocal cord mobility in thyroid surgery.</p><p><strong>Conclusion: </strong>TLUS is an effective non-invasive method for assessing VC function, with high diagnostic accuracy. With further advancements in ultrasound technology and standardized protocols, TLUS can be incorporated into routine clinical practice as a supplement to traditional laryngoscopy techniques. This study supports the use of TLUS as a viable alternative for preoperative and postoperative VC assessment in thyroid surgery patients.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"37 5","pages":"253-259"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}