Iranian Journal of Otorhinolaryngology最新文献

{"title":"Anti-inflammatory and Antioxidant Effects of Kaempferia galanga Extract in Acute Bacterial Rhinosinusitis: In Vivo Study on MDA, NF-κB, and CRP.","authors":"Aziza Viquisa Berliana Putri, Paramasari Dirgahayu, Bambangx Purwanto, Soetrisno Soetrisno, Betty Suryawati, Risya Cilmiaty, Hadi Sudrajad","doi":"10.22038/ijorl.2025.90356.4019","DOIUrl":"10.22038/ijorl.2025.90356.4019","url":null,"abstract":"<p><strong>Introduction: </strong>Acute bacterial rhinosinusitis (ABRS) is an inflammation of the paranasal sinuses caused by bacterial infection, primarily involving inflammatory responses and oxidative stress. While antibiotics are the standard treatment, their effectiveness can sometimes be limited. <i>Kaempferia galanga (K. galanga)</i>, a medicinal plant known for its anti-inflammatory and antioxidant properties, has shown potential as a therapeutic agent. This study aimed to evaluate the therapeutic efficacy of <i>K. galanga</i> extract in a mouse model of ABRS.</p><p><strong>Materials and methods: </strong>An in vivo experimental study was conducted using Sprague-Dawley rats with induced ABRS. The animals were randomly divided into three treatment groups that received <i>K. galanga</i> extract at doses of 150 mg/kg (KG150), 300 mg/kg (KG300), or 450 mg/kg (KG450) based on body weight. Therapeutic effects were assessed by measuring serum levels of MDA, NF-κB, and CRP.</p><p><strong>Results: </strong>Eighteen rats with ABRS were included in the study. The KG300 group exhibited significantly lower levels of MDA, NF-κB, and CRP compared to the KG150 and KG450 groups (p < 0.05). These findings suggest that the 300 mg/kg dose of <i>K. galanga</i> extract provides optimal therapeutic benefit.</p><p><strong>Conclusion: </strong><i>K. galanga</i> extract at 300 mg/kg demonstrated the most potent anti-inflammatory and antioxidant effects in a mouse model of ABRS, indicating its potential as an effective alternative or adjunctive therapy.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 1","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Call for Rigorous Clinical Trial: Effect of Intratympanic Dexamethasone on Bell's Palsy.","authors":"Srilakshmi R Rao, Chethana Ramesh, Pranaya Deepika","doi":"10.22038/ijorl.2025.85294.3866","DOIUrl":"10.22038/ijorl.2025.85294.3866","url":null,"abstract":"","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 1","pages":"71-72"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Curcumin in Workers with Noise-Induced Hearing Loss: Preliminary Report.","authors":"Rizky Amalia, Tengku-Siti-Hajar Haryuna, Adriztina Indri, Yuliani Mardiati Lubis, Adlin Adnan, Delfitri Munir, Taufik Ashar, Khalisanni Khalid","doi":"10.22038/ijorl.2026.89875.4010","DOIUrl":"10.22038/ijorl.2026.89875.4010","url":null,"abstract":"<p><strong>Introduction: </strong>Prolonged loud noise exposure causes sensorineural hearing loss through cochlear oxidative stress, requiring heat shock protein 70 (HSP70) for protection. Curcumin boosts antioxidant expression and safeguards the cochlea. Pure tone audiometry (PTA) measures the type of hearing loss and otoacoustic emission (OAE) detects early auditory issues. This study evaluated the impact of Curcumin on noise-exposed workers via PTA, OAE, and HSP70.</p><p><strong>Materials and methods: </strong>This preliminary study included 54 noise-exposed workers with hearing thresholds ≥26 dB and SNR values <6 dB. Participants were randomized into three noise-exposed groups: placebo (positive control), 500 mg Curcumin, or 1,000 mg Curcumin for 4 weeks. A negative control group of 18 non-exposed workers with normal hearing who received no treatment, served as an external reference only. HSP70 levels, PTA, and OAE were measured before and after intervention in all groups.</p><p><strong>Results: </strong>PTA showed a significant worsening of hearing threshold in the positive control group (p=0.001), significant improvement in Curcumin 500 mg group (p=0.046), in the Curcumin 1,000 mg (p=0.059). OAE revealed substantial worsening of SNR in the positive control group (p<0.001) and significant increase in the Curcumin 500 mg (p<0.05) at 4, 7, 8, and 9 kHz, and in the 1,000 mg groups (p<0.05) at 5, 8, and 9 kHz. HSP70 levels significantly increased in the positive control group (p=0.021), both Curcumin groups showed a non-significant increase.</p><p><strong>Conclusion: </strong>Curcumin was associated with improved hearing thresholds and favorable SNR changes in noise-exposed workers. Changes in HSP70 levels were minimal and not statistically significant in the curcumin groups.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 3","pages":"159-169"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasopharyngeal Branchial Cleft Cyst in an Elderly Man: An Atypical Presentation.","authors":"Gautam Bir Singh, Priyanka Sharma, Kavita Gaur","doi":"10.22038/ijorl.2026.95727.4153","DOIUrl":"10.22038/ijorl.2026.95727.4153","url":null,"abstract":"<p><strong>Introduction: </strong>Branchial cleft cysts (BCCs) account for nearly one-third of congenital cervical masses, but their occurrence within the nasopharynx is exceedingly uncommon. Most reported nasopharyngeal cases involve children or young adults; presentation in older patients raises concern for cystic metastasis from an occult head and neck malignancy.</p><p><strong>Case report: </strong>We describe a 64-year-old man with a three-year history of progressive bilateral nasal obstruction and recurrent rhinosinusitis. Endoscopy disclosed a smooth, mobile, midline pinkish nasopharyngeal mass; cross-sectional imaging confirmed a well-defined T2-hyperintense cystic lesion in the upper posterior nasopharynx. Endoscopic transnasal piecemeal excision was performed, and histopathology established a branchial cleft cyst without dysplasia or malignancy. The patient remained asymptomatic on follow-up.</p><p><strong>Conclusion: </strong>This case underscores the importance of including nasopharyngeal BCC in the differential diagnosis of cystic nasopharyngeal lesions, even in elderly patients in whom cystic carcinoma metastasis must first be excluded.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 5","pages":"341-345"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Histological Benefits of Gabapentin in Experimental Facial Nerve Crush Injury in Rats: Increased Myelinated Axons and S100-Positive Schwann Cells.","authors":"Farzaneh Fagheei, Maliheh Jahromi, Mohammad Javad Saeedi-Borujeni","doi":"10.22038/ijorl.2026.96859.4182","DOIUrl":"10.22038/ijorl.2026.96859.4182","url":null,"abstract":"<p><strong>Introduction: </strong>Some studies have shown that gabapentin administration is associated with neuroregeneration. The current study aimed to investigate the effects of daily gabapentin administration on the histological alterations of the facial nerve (FN) following experimental crush injury in Wistar rats.</p><p><strong>Materials and methods: </strong>Twenty- one Wistar rats were randomly divided into three groups of seven: a sham- control group, a vehicle group, and a gabapentin group that received gabapentin after nerve injury induction. At the end of the intervention, the animals were sacrificed under anesthesia, and FN tissue samples were collected to evaluate the number of myelinated axons and Schwann cells. The data were analyzed using SPSS software, and a <i>P</i> value of less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The mean number of myelinated axons was 37.00 ± 2.65 in the sham- control group, 19.86 ± 2.85 in the vehicle group, and 27.29 ± 2.93 in the gabapentin group, with the latter showing an intermediate value between the other two groups (η² = 0.879; <i>P</i> < 0.001). Similarly, the highest mean Schwann cell count was observed in the sham- control group (43.00 ± 2.89), whereas the lowest was found in the vehicle group (21.72 ± 2.06). The mean Schwann cell count in the gabapentin group was 34.29 ± 2.87 (η² = 0.928; <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Daily gabapentin administration following FN crush injury resulted in a considerable increase in myelinated axons and S100- positive Schwann cells. These findings suggest that gabapentin may support structural nerve repair after FN injury. Further functional evaluation and cellular and molecular studies are needed.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 5","pages":"317-325"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Case of Bilateral Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo with Asymmetric Mechanisms: Left Cupulolithiasis and Right Short-Arm Canalolithiasis.","authors":"Shreya Vats, Ajay Kumar Vats, Sudhir Kothari","doi":"10.22038/ijorl.2026.92534.4081","DOIUrl":"10.22038/ijorl.2026.92534.4081","url":null,"abstract":"<p><strong>Introduction: </strong>Benign paroxysmal positional vertigo (BPPV) involving multiple semicircular canals (MC-BPPV) is an uncommon variant in which otoconia dislodged from the utricular macula migrate into two or more canals, provoking brief vertigo episodes with positional changes. The single-canal variant predominates, most often affecting the posterior canal, followed by the horizontal and anterior canals. MC-BPPV typically presents with ipsilateral or contralateral posterior-horizontal canal combinations, while atypical posterior canal variants are rarer and require careful nystagmus evaluation during positional testing.</p><p><strong>Case report: </strong>A 62-year-old man presented with a one-day history of vertigo triggered by rising from the supine position, along with retropulsion and vertigo during transitions to lateral recumbent positions. Standard right Dix-Hallpike test (DHT) and right half DHT were unremarkable. Augmented right half-DHT elicited persistent upbeat right-torsional nystagmus; a negative inversion test indicated right short-arm posterior canalolithiasis. Left half-DHT evoked persistent left torsional upbeating nystagmus that reversed to downbeating nystagmus with a subtle right-torsional component on right lateral rolling nose-down, consistent with left posterior cupulolithiasis. The Bascule maneuver was used to treat the left ear, and the prone pitch-and-yaw maneuver was used to treat the right ear. Follow-up showed conversion of left posterior cupulolithiasis to typical canalolithiasis, which resolved with the Epley maneuver, resulting in complete symptom remission.</p><p><strong>Conclusions: </strong>This case highlights the importance of comprehensive positional testing and mechanism-specific therapeutic maneuvers for successful management of atypical bilateral MC-BPPV.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 3","pages":"197-201"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Recurrence Rate and Associated Risk Factors of Laryngeal Squamous Cell Carcinoma in Patients Undergoing Transoral Laser Microsurgery: A Retrospective Cohort Study.","authors":"Mohammad Amin Zaeim Yekeh, Aslan Ahmadi, Pegah Alizade Pahlavan, Mohammad Mahdi Salem","doi":"10.22038/ijorl.2025.90331.4018","DOIUrl":"10.22038/ijorl.2025.90331.4018","url":null,"abstract":"<p><strong>Introduction: </strong>Laryngeal squamous cell carcinoma (SCC) remains a significant health challenge, with transoral laser microsurgery (TLM) emerging as a preferred treatment for early-stage disease. This retrospective cohort study investigates recurrence patterns, survival outcomes, and prognostic factors in patients treated with TLM, with a focus on the role of smoking exposure.</p><p><strong>Materials and methods: </strong>A retrospective cohort study was conducted on 142 patients with laryngeal SCC treated with TLM at Rasoul Akram Hospital (2016-2022). Patient demographics, tumor characteristics, smoking history (Pack-Years), and follow-up data were analyzed. Recurrence rates and survival were assessed using Kaplan-Meier analysis, and risk factors were evaluated using univariate logistic regression and Cox proportional hazards models.</p><p><strong>Results: </strong>The recurrence rate was 26.1% (n=37), predominantly local (70.3%), with a median time to recurrence of 15 months. Smoking exposure significantly correlated with recurrence risk (OR=1.02, 95% CI: 1.00-1.03, p=0.02; HR=1.01, 95% CI: 1.00-1.02, p=0.04). Kaplan-Meier analysis revealed reduced recurrence-free survival for patients with >20 Pack-Years (p=0.04), while disease-free survival (DFS) probability was approximately 0.75 at 80 months. No significant associations were found for age, sex, tumor stage, or comorbidities (all p>0.05), and no distant metastases were observed.</p><p><strong>Conclusions: </strong>TLM appears to be an effective treatment for early-stage laryngeal SCC in this cohort, with smoking identified as a critical modifiable risk factor for recurrence. The findings underscore the importance of smoking cessation interventions to enhance outcomes. Given the retrospective and single-center design, conclusions should be interpreted cautiously. Future multi-center studies with extended follow-up and molecular profiling are recommended.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 1","pages":"19-27"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pepsin-induced Differential IL-6 Expression in Laryngeal and Laryngopharyngeal Tissue: Non-invasive Rat Model for Laryngopharyngeal Reflux.","authors":"Adelien Adelien, Irfannuddin Irfannuddin, Hardi Darmawan, Agus Surono, Krisna Murti, Debby Handayati Harahap, Elvie Zulka Kautzia Rachmawati","doi":"10.22038/ijorl.2026.93308.4101","DOIUrl":"10.22038/ijorl.2026.93308.4101","url":null,"abstract":"<p><strong>Introduction: </strong>Laryngopharyngeal reflux is a common condition caused by exposure of the upper aerodigestive tract to gastroduodenal content, resulting in inflammation to the area. Despite the condition being well documented in the human population, the literature on animal models for laryngopharyngeal reflux is currently limited. The aim of this study is to create a non-invasive model of laryngopharyngeal reflux using rats to investigate changes in IL-6 expression in the laryngeal and laryngopharyngeal regions.</p><p><strong>Materials and methods: </strong>Male Wistar rats, ranging from ages 10-14 weeks, were exposed to 0.5% bovine pepsin dissolved in artificial gastric juice three times daily for 5-15 days via a modified IV cannula in several volumes (0 mL, 0.1 mL, 0.15 mL, and 0.2 mL) according to the treatment groups. Subsequently, laryngeal and laryngopharyngeal tissue IL-6 concentrations were measured through ELISA on allotted days of sacrifice.</p><p><strong>Results: </strong>Significant differences in laryngeal and laryngopharyngeal tissue IL-6 concentration were measured (p = 0.005 and p = 0.020 respectively). Laryngeal expression of IL-6 was related to the volume administered (p = 0.007) but not to the duration of exposure (p = 0.338), with no significant interaction between duration of exposure and administered volume (p = 0.515). On the other hand, laryngopharyngeal expression of IL-6 was related to the duration of exposure (p< 0.001) but not to the volume administered (p = 0.521) with significant interaction between duration and volume (p < 0.001).</p><p><strong>Conclusion: </strong>The study established the feasibility of using a non-invasive rat model for studying laryngopharyngeal reflux. Additionally, the study demonstrated the differential responses of IL-6 to the addition of the acid-pepsin insult, with dose-dependent IL-6 responding more in laryngeal tissue and time-dependent IL-6 responding in laryngopharyngeal tissue.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 2","pages":"117-124"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombectomy in Lemierre's Syndrome: A Systematic Literature Review.","authors":"Jevaughn Davis, Crystal Adams, Puneet Gupta, Sonia Samant, Bridget Marcinkowski, Sarah Edwards, Wyatt Nice, Aryana Kavuri, Elaine Sullo, Akhil Patel","doi":"10.22038/ijorl.2025.91192.4043","DOIUrl":"10.22038/ijorl.2025.91192.4043","url":null,"abstract":"<p><strong>Introduction: </strong>Lemierre's syndrome (LS) is a rare but potentially life-threatening condition characterized by septic thrombophlebitis of the internal jugular vein, typically following an oropharyngeal infection. First described in 1936, the syndrome was once considered a \"forgotten disease\" due to its rarity in the post-antibiotic era. However, recent decades have witnessed a modest resurgence in reported cases, attributed in part to increased clinical awareness, improved diagnostic techniques, and evolving microbial resistance patterns. Antibiotics and anticoagulation remain mainstay of treatment with a high rate of treatment response. However, there is a small subset of patients that fail standard treatment and instead clinically deteriorate necessitating prolonged antibiotic therapy. This cohort of patients typically has unexpected critical care unit admissions and prolonged hospital stays. Historically, these patients would undergo vessel ligation. Thrombectomy has been proposed as an alternative to surgical vessel ligation for treatment resistant LS.</p><p><strong>Materials and methods: </strong>Using PubMed/MEDLINE and Scopus databases, we performed a comprehensive literature search on April 16, 2025, to identify studies relating to thrombectomy in Lemierre's Syndrome.</p><p><strong>Results: </strong>Four articles were found that fit inclusion criteria. Although limited by quantity, the studies found demonstrated that patients with treatment resistant disease usually had some clinical improvement after thrombectomy and on average had shorter intensive care unit and hospital stays.</p><p><strong>Conclusion: </strong>Thrombectomy use for treatment resistant LS is not well described in the literature. However, while not ideal or appropriate for every patient, there could exist a potential role for thrombectomy in patient with LS symptomology resistant to antibiotics and anticoagulation.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 2","pages":"75-81"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of Eustachian Tube Dysfunction in Patients Undergoing Septoplasty: Pre-operative Prevalence and Post-operative Outcomes.","authors":"Suhaima Pulimoottilparambil Saifuddeen","doi":"10.22038/ijorl.2026.92326.4073","DOIUrl":"10.22038/ijorl.2026.92326.4073","url":null,"abstract":"<p><strong>Introduction: </strong>The relationship between septoplasty and Eustachian Tube Dysfunction (ETD) remains controversial despite theoretical links between nasal anatomy and middle ear physiology.</p><p><strong>Materials and methods: </strong> Following PRISMA guidelines, we searched PubMed, Scopus, Web of Science, CENTRAL, and Embase up to October 2025 for studies examining ETD in septoplasty candidates. Twenty-eight studies (20 prospective cohorts, 5 retrospective cohorts, 3 RCTs; N≈2,150) met inclusion criteria.</p><p><strong>Results: </strong>Pre-operative ETD prevalence was high: 38-62% by ETDQ-7 questionnaire and 35-65% by tympanometry. Septoplasty significantly improved both subjective symptoms and objective middle ear function, with peak benefits at 3-6 months. Aural fullness showed the most notable improvement. Greater pre-operative ETD severity and posterior septal deviation were associated with more substantial improvement. Transient post-operative worsening occurred in some patients but resolved spontaneously.</p><p><strong>Conclusions: </strong>ETD is a frequent comorbidity in symptomatic deviated nasal septum patients. Septoplasty appears effective for concomitant ETD, supporting routine pre-operative ETD assessment and patient counseling about potential otological benefits. Evidence is moderate-level due to observational study dominance and heterogeneity.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"38 3","pages":"149-158"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}