{"title":"Cytocompatibility of Three Calcium Silicate-Based Biomaterials: A Systematic Review and Meta-Analysis.","authors":"Sahar Shabani Panbeh Choleh, Mahmoud Heidari, Ezatolah Kazeminejad, Masoud Mohammadi, Abdolhalim Rajabi","doi":"10.22037/iej.v21i1.48350","DOIUrl":"10.22037/iej.v21i1.48350","url":null,"abstract":"<p><strong>Introduction: </strong>To systematically evaluate and compare the <i>in vitro</i> cytotoxic effects of three calcium silicate-based cements [Mineral Trioxide Aggregate (MTA), Biodentine, and Calcium Enriched Mixture (CEM) Cement], focusing on their biocompatibility with human dental pulp cells in vital pulp therapy (VPT).</p><p><strong>Materials and methods: </strong>A comprehensive search was conducted in PubMed, Scopus, Web of Science, Cochrane, ProQuest, Wiley, and Ovid (including Embase) for <i>in vitro</i> studies published up to February 2023. Studies evaluating cytotoxicity via cell viability assays (<i>e.g</i>., MTT) were included.</p><p><strong>Results: </strong>Among 8,004 screened records, 32 studies met the inclusion criteria, with 11 included in the meta-analysis. Overall, no significant differences in cytotoxicity were identified among Mineral Trioxide Aggregate (MTA), Biodentine, and Calcium-Enriched Mixture (CEM) cement. Nevertheless, undiluted MTA and Biodentine at a 1:4 dilution were associated with a statistically significant reduction in cell viability at 48 hours (<i>P</i><0.05). No other concentrations or exposure durations showed significant cytotoxic effects. CEM cement consistently demonstrated favorable biocompatibility across the included studies.</p><p><strong>Conclusion: </strong>These findings indicate that MTA, Biodentine, and CEM cement generally exhibit acceptable <i>in vitro</i> biocompatibility for vital pulp therapy. Their biological responses may be influenced by material concentration and exposure duration, emphasizing the importance of careful and controlled clinical application.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e12"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehdi Rahimi, Antonia Lalousis, Mark Johnstone, Derek Mahony
{"title":"Endodontic and Orthodontic Management of a Fused Mandibular Incisor and Supernumerary: A Case Report.","authors":"Mehdi Rahimi, Antonia Lalousis, Mark Johnstone, Derek Mahony","doi":"10.22037/iej.v21i1.49822","DOIUrl":"10.22037/iej.v21i1.49822","url":null,"abstract":"<p><p>Dental fusion is a rare anomaly that can present unique challenges with clinical treatment. This report outlines a case of an 11-year-old who presented with fusion of a mandibular lateral incisor with a supernumerary. At presentation, the teeth were fully mature and normally responsive to pulp sensibility testing. Assessment with CBCT confirmed that the majority of the root canal system and pulp chambers were separate, with a single point of communication between both tooth units in the mid-crown. Removal of one of the teeth was requested to facilitate the patient's orthodontic treatment plan, and this was carried out with hemi-sectioning of the teeth, followed by vital pulp therapy of the exposed root canal systems of both teeth. At subsequent review, the tooth with the largest pulpal exposure was chosen for extraction, and the remaining tooth was recontoured for aesthetics. The teeth were subsequently aligned orthodontically. The patient was reviewed at 2.5 years, 3.5 years, and 9.5 years and was asymptomatic, with continued pulpal responsiveness and radiographically normal tissues.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e30"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endodontic Management of a Taurodontic Mandibular Second Premolar with Five Canals: A Case Report.","authors":"Abbasali Khademi, Mahsa Chamlanian Esfahani","doi":"10.22037/iej.v21i1.51661","DOIUrl":"10.22037/iej.v21i1.51661","url":null,"abstract":"<p><p>This case report presents the endodontic management of a hypertaurodontic mandibular second premolar with five root canals, a rare and complex anatomical variation. A 12-year-old male patient presented with a previously treated tooth (history of pulpotomy) with symptomatic apical periodontitis and necrotic pulp. Initial periapical radiographs suggested taurodontism, but conebeam computed tomography (CBCT) revealed the presence of five canals merging into four distinct apices. Under CBCT guidance, all canals were negotiated, cleaned, and shaped. An apical barrier was created with bioceramic material, followed by obturation using warm vertical condensation with resinbased sealer. At the sixmonth followup, the tooth was asymptomatic and radiographically satisfactory. This case highlights the diagnostic indispensability of CBCT in detecting intricate root canal configurations in taurodontic teeth and outlines a structured clinical protocol for managing such challenging anatomies.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e17"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tooth Autotransplantation of A Mandibular Third Molar Followed by Delayed Root Canal Treatment to Manage External Inflammatory Resorption: A Case Report.","authors":"Arturo Pineda-Lopez, Sofía Zanabria-Montoya, Berenice Jara-Chalco, Armida Álvarez-Montalván, Hernán Coaguila-Llerena","doi":"10.22037/iej.v21i1.48883","DOIUrl":"10.22037/iej.v21i1.48883","url":null,"abstract":"<p><p>Tooth autotransplantation (TA) is indicated in cases of structurally compromised teeth with poor prognosis when a donor tooth is available. This case report describes the TA of a mandibular right third molar (48) into the position of the mandibular right second molar (47) in a 32-year-old male patient. Clinically, extensive coronal destruction and a sinus tract were observed in tooth 47, rendering retreatment unfavorable. The tooth was diagnosed as previously treated, with a chronic apical abscess. Therefore, tooth 48 was autotransplanted into the 47 position. Four months later, apical external inflammatory root resorption was observed. However, root canal treatment was performed one year after TA because the patient did not adhere to follow-up recommendations. After two years, the tooth remained asymptomatic, with no signs of periapical lesions or periodontal changes. In conclusion, TA may serve as a viable strategy for replacing structurally compromised permanent molars, thereby preserving the function of the natural dentition.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e16"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruby Melissa Portilla Mendoza, Maria Mihaela Iuga, Mario George Casaretto Gamonal
{"title":"Efficacy of Bioceramic Cements Versus Conventional Cements in the Prognosis of Endodontic Treatments in Patients with Apical Periodontitis: A Systematic Review with Meta-Analysis.","authors":"Ruby Melissa Portilla Mendoza, Maria Mihaela Iuga, Mario George Casaretto Gamonal","doi":"10.22037/iej.v21i1.50633","DOIUrl":"10.22037/iej.v21i1.50633","url":null,"abstract":"<p><strong>Introduction: </strong>Successful management of apical periodontitis relies on effective root canal obturation to eliminate microbial activity and promote periapical healing. Bioceramic sealers have emerged as alternatives to conventional sealers due to their favorable biocompatibility and potential regenerative properties. However, their comparative clinical efficacy remains uncertain.</p><p><strong>Materials and methods: </strong>A systematic review and meta-analysis were conducted following PRISMA 2020 guidelines. Four electronic databases (PubMed, Scopus, Web of Science, and Embase) were searched for randomized controlled trials (RCTs) comparing bioceramic and conventional sealers. Three reviewers independently performed study selection, data extraction, and risk of bias assessment using the RoB 2.0 tool. The primary outcomes were apical healing and postoperative pain; secondary outcomes included adverse events and procedural complications. Meta-analysis was performed using a random-effects model.</p><p><strong>Results: </strong>From 491 identified records, 12 RCTs met the inclusion criteria. Meta-analysis of four studies found no statistically significant difference in healing rates between bioceramic and conventional sealers (RR=1.05, 95% CI: 0.89-1.23, P=0.61; I²=0%). No major adverse events were reported. Although bioceramic sealers have theoretical advantages, the current evidence does not support their clinical superiority over conventional sealers, as the meta-analysis showed non-significant results and some methodological limitations were identified.</p><p><strong>Conclusion: </strong>Bioceramic sealers appear to be clinically comparable to conventional sealers regarding periapical healing and postoperative outcomes. However, due to the limited and heterogeneous data, further high-quality RCTs with standardized outcome measures are needed to determine their relative effectiveness.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e11"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masoud Parirokh, Hamed Manochehrifar, Nozar Nakahee, Sina Kakooei, Shaghayegh Ghadimi
{"title":"Investigating the Association between the Presence of Pulp Stone and Anesthesia Failure in Upper and Lower Molar Teeth.","authors":"Masoud Parirokh, Hamed Manochehrifar, Nozar Nakahee, Sina Kakooei, Shaghayegh Ghadimi","doi":"10.22037/iej.v21i1.46586","DOIUrl":"10.22037/iej.v21i1.46586","url":null,"abstract":"<p><strong>Introduction: </strong>The close relationship between pulp stones in the pulp chamber and pulp neurovascular tissues suggests that the presence of pulp stones may compromise successful anesthesia. The present study assessed the effect of pulp stone presence on the failure of anesthesia in mandibular and maxillary molars.</p><p><strong>Materials & methods: </strong>In this retrospective cohort study, 126 patients were studied. Pulp stones were diagnosed by periapical radiography. After the anesthetic agent injection, failure was defined as patients raising their hand upon experiencing pain during any procedural step of endodontic treatment. Furthermore, sound, eye, and motor (SEM) measures were used to assess the pain experience. In the case of either pain felt or the patients' demand, supplementary injections were made using the intraligamental technique. Multivariate logistic regression analysis was used to assess the effects of different variables on the success of anesthesia.</p><p><strong>Results: </strong>The overall prevalence of pulp stones in the patients was 59.5%, with 42.9% and 57.1% for males and females, respectively. The incidence of pulp stones in patients under the age of 40 was 54.7%, whereas in the ≥40 age group, it was 64.5%. The highest incidences of pulp stones were reported for maxillary second (42.9%) and first (21.4%) molars, followed by mandibular second (18.6%) and first molars (17.1%). Overall, the success rate of anesthesia was 55.6% for treated teeth. However, no significant differences were observed in the success rate of anesthesia regarding gender, tooth type, and pulp stone presence. Only the age group of patients significantly predicted the success of anesthesia (Odds ratio: 1.135; CI 95%: 1.43-6.76; <i>P</i>=0.004).</p><p><strong>Conclusion: </strong>Pulp stones had no significant effect on the success of anesthesia in mandibular and maxillary molars.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e15"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nívia Mayally Duarte Oliveira, Wanderson Talles Do Nascimento, Cinthia Natali Pontes Dos Santos, Vinicius Gabriel Barros Florentino, Gustavo Pina Godoy, Inácio Ferraz Pinto Júnior, David Max Alves Soares, Luiz Felipe Siqueira Estima, Ana Maria Santos Perazzo Góes, Katarina Diniz Areias Carneiro De Albuquerque, Bárbara Laís Campos Teles, Jackeline Mayara Inácio Magalhães
{"title":"Cone-beam Computed Tomography Study of the Root Canal Morphology of Lower Incisors.","authors":"Nívia Mayally Duarte Oliveira, Wanderson Talles Do Nascimento, Cinthia Natali Pontes Dos Santos, Vinicius Gabriel Barros Florentino, Gustavo Pina Godoy, Inácio Ferraz Pinto Júnior, David Max Alves Soares, Luiz Felipe Siqueira Estima, Ana Maria Santos Perazzo Góes, Katarina Diniz Areias Carneiro De Albuquerque, Bárbara Laís Campos Teles, Jackeline Mayara Inácio Magalhães","doi":"10.22037/iej.v21i1.50408","DOIUrl":"10.22037/iej.v21i1.50408","url":null,"abstract":"<p><strong>Introduction: </strong>The present study aims to evaluate the root canal morphology of permanent lower incisors by cone-beam computed tomography (CBCT) according to Vertucci's classification (1984), and to correlate the findings with sex, age group, and side of the dental arch.</p><p><strong>Materials and methods: </strong>This was a descriptive observational study that used a sample of mandibular CBCT scans performed between 2021 and 2024 at a private dental radiology service. When none of the Vertucci configurations was applicable, type 0 was assigned.</p><p><strong>Results: </strong>Type I was the predominant morphological configuration, followed by type III, for all variables analyzed. Regarding sex, type I was more common among females (71.1%), while type III accounted for 21.2% in both males and females. With respect to age, type I was more common among minors (76.8%), and type III among older adults (23.3%). The type I configuration was more frequently observed on the right side of the dental arch (70.3%), and type III on the left side (21.9%).</p><p><strong>Conclusion: </strong>The anatomical observations of the lower incisors highlight the need for careful analysis of their internal morphology during endodontic treatment.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e8"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complex Dentoalveolar Trauma in a Growing Patient: Management of Avulsion and Alveolar Fracture.","authors":"Pourya Esmaeelpour, Maryam Forghani, Fatemeh Zourmand Ghasemi","doi":"10.22037/iej.v21i1.50396","DOIUrl":"10.22037/iej.v21i1.50396","url":null,"abstract":"<p><p>Traumatic dental injuries (TDIs) involving both tooth avulsion and alveolar fracture present significant clinical challenges, particularly in growing patients, where long-term restorative planning must accommodate ongoing craniofacial development. This report describes the multidisciplinary management of an 11-year-old boy who sustained avulsion of tooth #21 and an associated alveolar fracture following a sports-related injury. Clinical and cone-beam computed tomography evaluations revealed an alveolar segment fracture extending from teeth #12 to #21. The displaced segment was manually repositioned and stabilized using a flexible composite and wire splint. Subsequent loss of pulpal vitality in teeth #11 and #12 was managed by root canal treatment with interim calcium hydroxide therapy. Given the patient's incomplete skeletal growth, a minimally invasive Maryland bridge was selected to replace the missing tooth #21. Clinical and radiographic follow-up at 6 and 12 months demonstrated normal healing of the alveolar bone and periodontal structures, with no evidence of root resorption or ankylosis. Successful management of complex dentoalveolar trauma in growing patients requires early diagnosis, appropriate splinting, endodontic intervention when indicated, and growth-conscious prosthetic rehabilitation. Long-term follow-up is essential to monitor healing and plan future definitive treatment.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e10"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Osteogenic Response of Saos-2 Cells to Calcium Silicate-based versus Hydroxyapatite-based Cements: A Comparative Study.","authors":"Maryam Torshabi, Maryam Eydi, Saeed Asgary, Zohreh Fazli, Safoora Modagheghi, Azam Valian, Hanieh Nojehdehian","doi":"10.22037/iej.v21i1.46947","DOIUrl":"10.22037/iej.v21i1.46947","url":null,"abstract":"<p><strong>Introduction: </strong>Bioceramic materials are integral to regenerative endodontics, yet comparative data on their osteogenic potential remain limited. This study compared the osteogenic potential of four bioceramics: hydroxyapatite (HA), a nano-hydroxyapatite/chitosan composite (n-HA/CSS), Angelus mineral trioxide aggregate (MTA), and calcium-enriched mixture (CEM) cement.</p><p><strong>Materials and methods: </strong>Human osteoblast-like Saos-2 cells were exposed to materials <i>via</i> direct contact and extract models. Cell viability and proliferation were assessed using the MTT assay, attachment and morphology were examined by scanning electron microscopy (SEM), and osteogenic differentiation was evaluated by real-time PCR for alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteocalcin (OC) at 3 and 6 days.</p><p><strong>Results: </strong>All materials were non-cytotoxic. In direct culture, CEM significantly enhanced cell proliferation by day 3 (~3-fold, <i>P</i><0.001). SEM revealed superior cell attachment and extracellular matrix secretion on n-HA/CS and CEM surfaces. Gene expression analysis demonstrated that CEM robustly upregulated ALP (~12-fold <i>vs.</i> control, <i>P</i><0.001), a level 6-fold higher than MTA (<i>P</i><0.05). Furthermore, both CEM and n-HA/CS promoted pronounced expression of the late markers BSP (~5-fold, <i>P</i><0.001) and OC (10-fold and 12-fold, <i>P</i><0.001 and <i>P</i><0.001, respectively). MTA consistently elicited the lowest osteogenic response.</p><p><strong>Conclusions: </strong>CEM and the n-HA/CS were identified as the strongest promoters of osteoblast proliferation and differentiation, indicating their superior bioactivity over MTA and HA and their potential for endodontic and surgical hard tissue regeneration.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e3"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bio-obturation Repair of Extensive External Root Resorption in Neglected Avulsed Teeth: A Case Report.","authors":"Rezvan Shahhosseini, Mandana Naseri, Fateme Javand","doi":"10.22037/iej.v21i1.50474","DOIUrl":"10.22037/iej.v21i1.50474","url":null,"abstract":"<p><p>Tooth avulsion represents a severe dental injury, and prognosis depends on extraoral time and storage. Its major complications include ankylosis and external inflammatory root resorption. We report a 14-year-old female who presented with pain in her upper incisors one year after avulsion of teeth 11 and 21, replanted after 60 minutes in dry cloth and splinted for four months without follow-up. Clinical and radiographic examinations were consistent with severe external inflammatory root resorption in the teeth #11, 12, 21, and 22. Given her age and unsuitability for implants, staged endodontic therapy was performed over four months. Canals were prepared under rubber dam isolation, irrigated with 17% EDTA and 5.25% sodium hypochlorite with ultrasonic activation, and dressed with non-setting calcium hydroxide. Dressing was refreshed at sequential visits until resorption stabilized. Final obturation used calcium-enriched mixture (CEM) cement at perforations and gutta-percha in remaining canal spaces, and AH-26 sealer was used as sealant. Our treatment arrested resorption and preserved function, though the long-term risk of ankylosis remains high. This case report underscores the need for immediate replantation, physiologic storage media, and timely endodontic intervention to mitigate complications. Close monitoring remains vital for maintaining aesthetics and function in growing patients.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e5"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}