Iranian Endodontic Journal最新文献_第2页

Osteogenic Response of Saos-2 Cells to Calcium Silicate-based versus Hydroxyapatite-based Cements: A Comparative Study. Saos-2细胞对硅酸钙骨水泥和羟基磷灰石骨水泥成骨反应的比较研究

Iranian Endodontic Journal Pub Date : 2026-01-01 Epub Date: 2023-12-28 DOI: 10.22037/iej.v21i1.46947

Maryam Torshabi, Maryam Eydi, Saeed Asgary, Zohreh Fazli, Safoora Modagheghi, Azam Valian, Hanieh Nojehdehian

{"title":"Osteogenic Response of Saos-2 Cells to Calcium Silicate-based versus Hydroxyapatite-based Cements: A Comparative Study.","authors":"Maryam Torshabi, Maryam Eydi, Saeed Asgary, Zohreh Fazli, Safoora Modagheghi, Azam Valian, Hanieh Nojehdehian","doi":"10.22037/iej.v21i1.46947","DOIUrl":"10.22037/iej.v21i1.46947","url":null,"abstract":"Introduction: Bioceramic materials are integral to regenerative endodontics, yet comparative data on their osteogenic potential remain limited. This study compared the osteogenic potential of four bioceramics: hydroxyapatite (HA), a nano-hydroxyapatite/chitosan composite (n-HA/CSS), Angelus mineral trioxide aggregate (MTA), and calcium-enriched mixture (CEM) cement.Materials and methods: Human osteoblast-like Saos-2 cells were exposed to materials via direct contact and extract models. Cell viability and proliferation were assessed using the MTT assay, attachment and morphology were examined by scanning electron microscopy (SEM), and osteogenic differentiation was evaluated by real-time PCR for alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteocalcin (OC) at 3 and 6 days.Results: All materials were non-cytotoxic. In direct culture, CEM significantly enhanced cell proliferation by day 3 (~3-fold, P<0.001). SEM revealed superior cell attachment and extracellular matrix secretion on n-HA/CS and CEM surfaces. Gene expression analysis demonstrated that CEM robustly upregulated ALP (~12-fold vs. control, P<0.001), a level 6-fold higher than MTA (P<0.05). Furthermore, both CEM and n-HA/CS promoted pronounced expression of the late markers BSP (~5-fold, P<0.001) and OC (10-fold and 12-fold, P<0.001 and P<0.001, respectively). MTA consistently elicited the lowest osteogenic response.Conclusions: CEM and the n-HA/CS were identified as the strongest promoters of osteoblast proliferation and differentiation, indicating their superior bioactivity over MTA and HA and their potential for endodontic and surgical hard tissue regeneration.","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e3"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-obturation Repair of Extensive External Root Resorption in Neglected Avulsed Teeth: A Case Report. 生物封闭修复被忽视的脱脱牙广泛外根吸收1例。

Iranian Endodontic Journal Pub Date : 2026-01-01 Epub Date: 2025-12-28 DOI: 10.22037/iej.v21i1.50474

Rezvan Shahhosseini, Mandana Naseri, Fateme Javand

{"title":"Bio-obturation Repair of Extensive External Root Resorption in Neglected Avulsed Teeth: A Case Report.","authors":"Rezvan Shahhosseini, Mandana Naseri, Fateme Javand","doi":"10.22037/iej.v21i1.50474","DOIUrl":"10.22037/iej.v21i1.50474","url":null,"abstract":"Tooth avulsion represents a severe dental injury, and prognosis depends on extraoral time and storage. Its major complications include ankylosis and external inflammatory root resorption. We report a 14-year-old female who presented with pain in her upper incisors one year after avulsion of teeth 11 and 21, replanted after 60 minutes in dry cloth and splinted for four months without follow-up. Clinical and radiographic examinations were consistent with severe external inflammatory root resorption in the teeth #11, 12, 21, and 22. Given her age and unsuitability for implants, staged endodontic therapy was performed over four months. Canals were prepared under rubber dam isolation, irrigated with 17% EDTA and 5.25% sodium hypochlorite with ultrasonic activation, and dressed with non-setting calcium hydroxide. Dressing was refreshed at sequential visits until resorption stabilized. Final obturation used calcium-enriched mixture (CEM) cement at perforations and gutta-percha in remaining canal spaces, and AH-26 sealer was used as sealant. Our treatment arrested resorption and preserved function, though the long-term risk of ankylosis remains high. This case report underscores the need for immediate replantation, physiologic storage media, and timely endodontic intervention to mitigate complications. Close monitoring remains vital for maintaining aesthetics and function in growing patients.","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e5"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-surgical Endodontic Management of a Maxillary Central Incisor with Vertucci's Type V Morphology: A 57-month Follow-up Case Report. 上颌中切牙V型形态的非手术根管治疗：57个月随访病例报告。

Iranian Endodontic Journal Pub Date : 2026-01-01 Epub Date: 2026-01-26 DOI: 10.22037/iej.v21i1.46901

Key Fabiano Souza Pereira, Fábio Nakao Arashiro, Edilson José Zafalon

{"title":"Non-surgical Endodontic Management of a Maxillary Central Incisor with Vertucci's Type V Morphology: A 57-month Follow-up Case Report.","authors":"Key Fabiano Souza Pereira, Fábio Nakao Arashiro, Edilson José Zafalon","doi":"10.22037/iej.v21i1.46901","DOIUrl":"10.22037/iej.v21i1.46901","url":null,"abstract":"Maxillary central incisors typically exhibit a single root and canal. The presence of two roots with separate canals, as defined by Vertucci's type V morphology, is extremely rare and presents diagnostic and technical challenges for nonsurgical endodontic treatment. This report describes the endodontic management of a maxillary right central incisor (tooth #11) exhibiting a sinus tract, negative responses to pulp sensibility tests, and radiographic evidence of apical periodontitis in a 24-year-old female patient. Cone-beam computed tomography (CBCT) revealed a two-rooted anatomy with independent canals splitting at the middle third. Under magnification, access was refined using ultrasonic tips. The palatal root canal was prepared with NiTi CM rotary files, while the wider buccal canal was instrumented with stainless steel K-files. Both canals were disinfected using passive ultrasonic irrigation with 2.5% sodium hypochlorite and 17% EDTA, followed by intracanal calcium hydroxide medication. Obturation was completed using the single-cone technique with a bioceramic sealer. Radiographic follow-up at 14 and 57 months confirmed complete periapical healing and absence of symptoms, demonstrating long-term clinical success. Atypical root canal anatomy in maxillary incisors necessitates advanced imaging/magnification. The use of CBCT, NiTi CM files, and bioceramic sealers enabled accurate diagnosis, conservative canal shaping, and a successful long-term outcome in this rare morphology case.","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"21 1","pages":"e6"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Endodontic Techniques for Treating Root Perforation in a Hypertaurodont Molar: A Case Report. 先进的根管技术治疗高牛头牙磨牙根穿孔1例报告。

Iranian Endodontic Journal Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.22037/iej.v20i1.46431

Ali Chamani, Maryam Forghani, Mina Zarei, Pouria Soltaninezhad

引用次数: 0

Vital Pulp Therapy: Evidence-Based Techniques and Outcomes. 重要牙髓治疗：基于证据的技术和结果。

Iranian Endodontic Journal Pub Date : 2025-01-01 DOI: 10.22037/iej.v20i1.47141

Saeed Asgary, Ali Nosrat

{"title":"Vital Pulp Therapy: Evidence-Based Techniques and Outcomes.","authors":"Saeed Asgary, Ali Nosrat","doi":"10.22037/iej.v20i1.47141","DOIUrl":"10.22037/iej.v20i1.47141","url":null,"abstract":"Vital pulp therapy (VPT) comprises a range of conservative treatment modalities aimed at preserving the vitality of the compromised dental pulp in primary and permanent teeth. This PubMed-based review comprehensively evaluates seven distinct VPT techniques; including their historical development, broad definitions, clinical protocols and treatment outcomes as evidenced by systematic reviews and meta-analyses. The VPT modalities covered in this review include stepwise excavation, indirect pulp capping, direct pulp capping, miniature pulpotomy, partial pulpotomy, full pulpotomy and partial pulpectomy. Stepwise excavation, as a minimally-invasive option, has demonstrated effectiveness in reducing the risk of pulp exposure, particularly in permanent teeth. Clinical outcomes of indirect and direct pulp capping are promising; specifically with the application of advanced calcium silicate cements. Miniature and partial pulpotomies emphasize the importance of precise definitions and standardised protocols due to their subtle differences. Full pulpotomy has emerged as a viable alternative to root canal treatment, achieving comparable success rates in managing irreversible pulpitis. While partial pulpectomy remains the most invasive approach, it has shown potential in managing complex cases, such as root resorption, through selective tissue preservation. Despite advancements in biomaterials and technique standardisation, challenges remain, including variability in clinical protocols, limited high-quality evidence, and the need for long-term studies to better evaluate anticipated outcomes. Nevertheless, emerging biotechnologies hold promise for enhancing the precision and predictability of VPT procedures in the future.","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"20 1","pages":"e2"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endodontic Management of a C-shaped Mandibular Second Premolar with Four Canals and Four Apical Foramina: A Case Report. 四管四尖孔c型下颌第二前磨牙的根管治疗1例。

Iranian Endodontic Journal Pub Date : 2025-01-01 Epub Date: 2025-09-06 DOI: 10.22037/iej.v20i1.47626

Zahra Jafari, Ali Kazemi, Mohammadreza Rahmatian

{"title":"Endodontic Management of a C-shaped Mandibular Second Premolar with Four Canals and Four Apical Foramina: A Case Report.","authors":"Zahra Jafari, Ali Kazemi, Mohammadreza Rahmatian","doi":"10.22037/iej.v20i1.47626","DOIUrl":"10.22037/iej.v20i1.47626","url":null,"abstract":"A thorough understanding of root canal morphology is critical for achieving predictable outcomes in endodontic therapy. Anatomical variations in mandibular second premolars are uncommon compared to other teeth, and the coexistence of a C-shaped root canal configuration with four independent canals and four separate apical foramina is exceptionally rare. This case report describes the nonsurgical endodontic management of a mandibular second premolar exhibiting this unique morphology, confirmed through cone-beam computed tomography (CBCT) and magnification. A 52-year-old male was referred by a prosthodontist for elective root canal treatment before post placement. CBCT imaging revealed a C-shaped root in the coronal third that bifurcated into four separate canals at the midroot level, each terminating in an independent apical foramen. Nonsurgical treatment was performed over two visits, using meticulous chemo-mechanical preparation, intracanal calcium hydroxide dressing, and warm vertical compaction obturation. At the 9-month follow-up, the tooth was functional, asymptomatic, and radiographically stable. This case underscores the importance of preoperative assessment with advanced imaging and magnification in identifying and successfully treating rare endodontic anatomies.","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"20 1","pages":"e33"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12554238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145377276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guided Endodontic Technique in Mandibular Incisors with Pulp Canal Obliteration: A Case Report. 下颌切牙髓管闭塞引导根管技术1例报告。

Iranian Endodontic Journal Pub Date : 2025-01-01 Epub Date: 2025-05-11 DOI: 10.22037/iej.v20i1.47737

Saide Nabavi, Erfan Latifian

{"title":"Guided Endodontic Technique in Mandibular Incisors with Pulp Canal Obliteration: A Case Report.","authors":"Saide Nabavi, Erfan Latifian","doi":"10.22037/iej.v20i1.47737","DOIUrl":"10.22037/iej.v20i1.47737","url":null,"abstract":"The American Association of Endodontics classifies the management of pulp canal obliteration (PCO) cases as a high-risk difficulty. This classification indicates an increased likelihood of procedural errors. However, advancements in dental technology have simplified the endodontic treatment of calcified teeth. Guided endodontics uses cone-beam computed tomography (CBCT) and a three-dimensional (3D) printer to create a patient-specific guide, enhancing accuracy and predictability in complex cases. A healthy 60-year-old male was referred by a prosthodontist for root canal treatment on teeth #23, #24, and #25. Periapical radiographic examination revealed partial PCO in all teeth. After choosing guided endodontics treatment, CBCT imaging and intraoral 3D scanning were utilized to design a patient-specific endodontic guide. After verifying the stability of the endo-guide, access cavities were prepared using a Munce Discovery bur. Following the negotiation of the canals, the working length was determined. Root canal treatment was performed using rotary files up to size 25/0.04% and sodium hypochlorite irrigation. The obturation was completed using the warm condensation technique. Although PCO was present, no complications occurred during treatment. The teeth remained completely asymptomatic and functional, demonstrating the success of the treatment. Guided endodontics can be a practical and predictable approach for managing PCO in mandibular incisors. This technique provides accurate canal location, reduces procedural errors, and preserves tooth structure. Despite concerns about cost, radiation exposure, and challenges with anatomical variations, it represents a promising advancement in endodontic treatment.","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"20 1","pages":"e21"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid Approach to Manage Inflammatory Internal Root Resorption: A Case Report. 治疗炎症性内根吸收的混合方法：1例报告。

Iranian Endodontic Journal Pub Date : 2025-01-01 Epub Date: 2025-03-08 DOI: 10.22037/iej.v20i1.46677

Arezoo Mirzaie, Nazanin Zargar, Rezvan Shahhosseini

引用次数: 0

Mental Nerve Paresthesia, a Complication of Anesthesia in Non-surgical Endodontic Treatment: A Case Report . 精神神经感觉异常，麻醉在非手术根管治疗中的并发症：1例报告 。

Iranian Endodontic Journal Pub Date : 2025-01-01 DOI: 10.22037/iej.v20i1.45478

Rosmery Munguia-Osorio, Cesar Andre Zevallos-Quiroz

{"title":"Mental Nerve Paresthesia, a Complication of Anesthesia in Non-surgical Endodontic Treatment: A Case Report .","authors":"Rosmery Munguia-Osorio, Cesar Andre Zevallos-Quiroz","doi":"10.22037/iej.v20i1.45478","DOIUrl":"10.22037/iej.v20i1.45478","url":null,"abstract":"Paresthesia is described as a burning or prickling sensation or partial numbness caused by neurologic injury. The sensory loss may be the result of a reversible and/or irreversible nerve damage, and it can be caused by local or systemic factors. Local factors include traumatic injuries caused by impacted teeth, local injection, endodontic therapy, implant placement and exposure to toxic materials. This article reports a paresthesia by anesthetic injection. A 44-year-old man reported moderate pain during chewing and exposure to cold. Upon clinical examination, extension of the tooth fracture line was in the mesiodistal region of the mandibular left second premolar crown and was detected with 16× magnification of microscope. The diagnosis was cracked tooth syndrome, and root canal treatment was indicated. After the first appointment the patient reported altered sensation on left side of mandible, numbness and electric shock sensation, and therefore was diagnosed with mental nerve paresthesia. Diclofenac sodium, thiamine, cyanocobalamin, and pyridoxine were prescribed for 7 days as part of the treatment, and then root canal and restorative treatments were completed. Patient was scheduled for follow-up appointments after 1, 3, 6, and 8 months. After the first month, the feeling of paresthesia was still present and the patient was experiencing a painful \"electric shock\". At the 8-month follow-up visit, the paresthesia had been resolved with return of normal sensation.","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"20 1","pages":"e5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Dental Lasers in the Field of Endodontics: A Review of Literature. 牙科激光在牙髓学领域的应用：文献综述。

Iranian Endodontic Journal Pub Date : 2025-01-01 Epub Date: 2025-11-05 DOI: 10.22037/iej.v20i1.46956

Kimia Ghods, Ehsan Asnaashari, Andia Dehmoobed, Seyedehelina Motaharitabari, Nazanin Tofighirad

{"title":"Application of Dental Lasers in the Field of Endodontics: A Review of Literature.","authors":"Kimia Ghods, Ehsan Asnaashari, Andia Dehmoobed, Seyedehelina Motaharitabari, Nazanin Tofighirad","doi":"10.22037/iej.v20i1.46956","DOIUrl":"10.22037/iej.v20i1.46956","url":null,"abstract":"The present study aims to provide readers with the influence of various types of dental lasers in endodontics, along with their advantages and disadvantages. A complete query was carried out on PubMed, Google Scholar, Embase, and Scopus databases, and the studies published during 2015-2024 were collected using the keywords \"Laser,\" \"Endodontics,\" \"Disinfection,\" \"Vital Pulp therapy,\" and \"Regenerative Endodontic Treatment.\" After applying appropriate inclusion and exclusion criteria, 86 relevant articles focused on the application of dental lasers in endodontics were selected and evaluated. Based on the evaluated studies, probably the most significant advancement of dental lasers is in optimizing the treatment outcome of root canal therapy via enhanced disinfection of root canals. Moreover, various research has shown that dental lasers can also aid in diagnosing vitality of pulp, vital pulp therapy, apiectomy, regenerative treatments, pain management treatment after root canal therapy, access cavity preparation, sterilization and irrigation of root canals, treatment of periapical lesions, removing excess materials and broken instruments in canals, and prompting the healing process after root canal therapy. As evidenced by the obtained results, diode and erbium lasers have the most applications in endodontics with the lowest side effects. Nonetheless, all dental lasers face multiple limitations, including producing noticeable thermal changes and smoke and damaging surrounding structures at the emission site, which question their safe usage in clinical practice. Therefore, dental lasers' newest advancements in dental procedures require further scientific work in the future.","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"20 1","pages":"e44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12682321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0