Iranian Endodontic Journal最新文献

{"title":"Invasive Cervical Root Resorption: A Comprehensive Review on Pathogenesis, Diagnosis, and Treatment.","authors":"Saeed Asgary, Omid Dianat","doi":"10.22037/iej.v19i1.44246","DOIUrl":"10.22037/iej.v19i1.44246","url":null,"abstract":"<p><p>Invasive cervical root resorption (ICRR) is a dental pathology, marked by unexpected destruction originating in the cervical region of the tooth. This comprehensive literature review provides a holistic view into the pathogenesis, clinical manifestation, and precise management of ICRR, aiming to guide endodontists and enhance patient care and treatment outcomes. The review delves into the potential etiology of ICRR, covering contributing factors such as trauma, orthodontic treatment, and other pertinent conditions. It outlines the clinical and radiographic indicators, underscoring the crucial role of early detection and precise diagnosis in effectively managing and halting ICRR progression. The exploration of treatment approaches is thorough, ranging from non-surgical methods like vital pulp therapy or root canal treatment to surgical interventions. This review accentuates the essential role of interdisciplinary collaboration among diverse dental specialties in enhancing ICRR management. It highlights the importance of a consolidated strategy in enhancing treatment outcomes and preserving tooth structure and function. Moreover, it investigates prevention methods, risk evaluation, and identifies prospective research pathways to address the existing knowledge gaps.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 1","pages":"2-12"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10787181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Vivo</i> Evaluation of Tissue Biocompatibility of Calcium Silicate-based and Epoxy Resin-based Sealers.","authors":"George Táccio de Miranda Candeiro, Amanda Kevys Magalhães, Laissa Sousa Evangelista, Amanda Brito Santos, Larissa Bernardo Dantas, Hermano Camelo Paiva, Giulio Gavini, Paulo Goberlânio de Barros Silva","doi":"10.22037/iej.v19i4.45646","DOIUrl":"10.22037/iej.v19i4.45646","url":null,"abstract":"<p><strong>Introduction: </strong>Calcium silicate-based sealers are an alternative to be used into root canal, mainly to their biological properties. However, some biological parameters need to be determined in an <i>in vivo</i> animal research model. So, the aim of the present study was to evaluate <i>in vivo</i> the tissue biocompatibility of a calcium silicate-based sealer (EndoSequence BC Sealer) and an epoxy resin-based sealer (AH-Plus).</p><p><strong>Materials and methods: </strong>Polyethylene tubes were filled with freshly mixed sealers and implanted in connective subcutaneous tissue of 25 rats (5/euthanasia day) (<i>Rattus norvegicus albinus</i>). Empty tubes were used as controls and no tubes as sham. Histopathological (hematoxylin eosin) and histochemical (Picrosirius red) examinations were conducted at 3, 7, 15, 30 and 60 days (five rats/day) after the implantation procedure (<i>n</i>=5/group). The type/intensity of inflammation and collagenesis was analyzed statistically with Friedman or Kruskal-Wallis/Dunn tests (<i>P</i><0.05).</p><p><strong>Results: </strong>The profile of inflammation induced by AH-Plus (Median=2, Range=2-3) was significantly greater than that by Endosequence BC Sealer (Median=1, Range=1-1) during the 15-day experimentation period (<i>P</i>=0.018). After 30 days, both materials produced similar tissue reaction (<i>P</i>>0.05). AH-Plus and Endosequence BC Sealer (Median=2, Range=1-2) induced a high level of fibrosis after 60-day than control (Median=1, Range=1-1) and sham (Median=0, Range=0-0) groups (<i>P</i><0.001) of fibrosis based in type I collagen increase (<i>P</i>=0.025 and <i>P</i>=0.021, respectively). Tissue necrosis was not observed and the bioceramic sealer showed significant signs of endocytosed (Median=1, Range=1-1) material after 7 days than other groups (Median=0, Range=0-0) (<i>P</i><0.05). The calcium silicate-based sealer induced tissue repair faster than the epoxy resin-based sealer tested. However, both materials showed adequate biocompatibility and tolerance by subcutaneous tissues, with few differences in inflammatory profiles, formation of granulation tissue, and collagenesis.</p><p><strong>Conclusions: </strong>It may be concluded that calcium silicate-based sealer (EndoSequence BC Sealer) and an epoxy resin-based sealer (AH-Plus) presented suitable biocompatibility.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 4","pages":"278-286"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic Therapy in a Lateral Maxillary Incisor with Dens in Dente Type Ⅱ and Primary Endodontic Lesion: Case Report.","authors":"Maryam Amiri, Arezoo Mirzaie","doi":"10.22037/iej.v19i2.43487","DOIUrl":"https://doi.org/10.22037/iej.v19i2.43487","url":null,"abstract":"<p><p>Endodontic treatment in dens invaginatus anomaly is associated with challenges in all stages. This case report outlines the therapy provided for tooth #10 with occasional pain. In examinations, tenderness to percussion and touch and non-response to sensibility tests were observed, and pulp necrosis and symptomatic periapical periodontitis were diagnosed. Radiographic evaluation showed a structural anomaly related to the dens invaginatus and the associated periapical lesion. Cone-beam computed tomography confirmed the presence of DI type II. Endodontic treatment combined with photodynamic therapy and active irrigation using a dental operating microscope was successful and radiographic examinations showed periapical healing along with bone formation in 6-month and 1-year follow-ups.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 2","pages":"130-133"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10988645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Passive Ultrasonic Irrigation of the Photosensitizer Used in Photodynamic Therapy on Microbial Reduction in the Root Canal System: An <i>in Vitro</i> Study.","authors":"Danuza Santos Silvestre de Almeida, Alexandre Sigrist De Martin, Daniel Guimarães Pedro Rocha, Carlos Eduardo Fontana, Rina Andréia Pelegrine, Pelegrine da Silveira Bueno, Sérgio Luiz Pinheiro","doi":"10.22037/iej.v19i2.36934","DOIUrl":"https://doi.org/10.22037/iej.v19i2.36934","url":null,"abstract":"<p><strong>Introduction: </strong>The success of endodontic treatment is based on microbial reduction promoted by the interaction of chemical and mechanical procedures. Photodynamic therapy (PDT) is used as an adjunct to conventional treatment, with significant microbial reduction. This study aimed to evaluate the influence of passive ultrasonic irrigation (PUI) of the photosensitizer (PS) used in PDT on microbial reduction in the root canal system.</p><p><strong>Materials and methods: </strong>Forty-five mesiobuccal root canals from extracted human mandibular molars that were inoculated with standard strains of <i>Enterococcus faecalis</i>, <i>Candida albicans</i>, and <i>Streptococcus mutans</i> for 21 days were selected. The root canals were prepared using the ProTaper Next system and randomly divided into 3 groups (<i>n</i>=15): 1) PDT: PDT alone; 2) PUI+PDT: PUI followed by PDT; and 3) PUI/PS+PDT: PUI of the PS followed by PDT. Microbiological samples were collected from the canals before and after using the protocols described above. The data were analyzed by analysis of variance (Tukey's test) at a significance level of 5%.</p><p><strong>Results: </strong>Microbial counts before PDT, PUI+PDT, and PUI/PS+PDT did not differ significantly (<i>P</i>>0.05), showing methodological standardization in the microbial contamination of the root canal system. There was a significant reduction in microbial counts after PDT (61.05%), PUI+PDT (65.04%), and PUI/PS+PDT (68.58%) (<i>P</i><0.01), but with no statistically significant difference between the three groups (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>Based on the present findings, it was concluded that the combination of PUI with PDT or PS activation did not influence microbial reduction achieved by PDT alone.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 2","pages":"105-111"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10988636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Occupational Burnout and Job Satisfaction among Endodontists in Iran.","authors":"Bahareh Hosseini, Hamed Manochehrifar, Arash Shahravan, Aseman Yazdani, Tayebeh Malek Mohammadi, Iman Mohammadzadeh, Amir Hossein Nekouei","doi":"10.22037/iej.v19i3.42440","DOIUrl":"10.22037/iej.v19i3.42440","url":null,"abstract":"<p><strong>Introduction: </strong>Occupational burnout has been introduced as one of the most critical social problems. The present study aimed to evaluate occupational burnout among a group of Iranian endodontists.</p><p><strong>Material and methods: </strong>Seventy-two Iranian endodontists participated in this cross-sectional study by completing the abbreviated Maslach Burnout Inventory (aMBI), consisting of one questionnaire in three domains. The data were analyzed with SPSS 21, using the chi-squared test, correlation test, and linear regression.</p><p><strong>Results: </strong>Concerning occupational burnout, 2.9% of the participants had severe emotional exhaustion, 4.2% exhibited an intense feeling of decreased accomplishment, 67.2% exhibited moderate occupational burnout, and 78.9% of the participants were satisfied with their job. Of all the variables, only the years elapsed since graduation had an inverse and significant correlation with occupational burnout among endodontists.</p><p><strong>Conclusion: </strong>The overall mean scores of endodontists showed a moderate rate of occupational burnout compared to the standard mean scores in this field. Recent graduates exhibited higher scores.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 3","pages":"216-222"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Coronal Adaptation of Root Canal Fillings with a Modified Single-Cone Obturation Technique: Two Case Reports.","authors":"Mahmood Reza Kalantar Motamedi, Brett E Gilbert, William N Ha","doi":"10.22037/iej.v19i1.43991","DOIUrl":"10.22037/iej.v19i1.43991","url":null,"abstract":"<p><p>The single-cone technique, also known as the hydraulic condensation technique, is widely employed in endodontics. However, the aforementioned method is presented with certain limitations; specifically concerning the coronal seal and the adaptation of the coronal third of a master gutta-percha (GP) with a round cross-section to the coronal dentinal walls of root canals with semi-round or oval cross-sections. Through two case reports, the current article introduces the coronal vertical condensation (CVC) technique; aiming to enhance GP adaptation to canal walls in similar scenarios. In fact, the coronal vertical condensation technique amalgamates the different aspects of warm vertical condensation and single-cone techniques. In CVC, following the placement of the master GP cone, an electrical heat carrier is inserted immediately a few millimeters apical from the canal orifice to remove the coronal portion of the master GP cone. Subsequently, a hand plugger is used to condense GP in the vertical dimension, and the coronal space is backfilled using melted GP. The implementation of CVC technique has demonstrated an improved coronal adaptation of GP with canal walls. The stated technique seems beneficial; especially in the obturation of severely curved canals or root canals with a final preparation shape of variable taper.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 1","pages":"50-55"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10787180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Niosomal Doxycycline and Triamcinolone: A Novel Approach to Minimize Cytotoxicity in Endodontic Medicaments.","authors":"Rahim Fereidooni, Arash Shahravan, Hamed Manochehrifar, Abbas Pardakhty, Fatemeh Nosrati, Hamid Reza Mollaie","doi":"10.22037/iej.v19i1.42608","DOIUrl":"10.22037/iej.v19i1.42608","url":null,"abstract":"<p><strong>Introduction: </strong>Mechanical root canal preparations and irrigation solutions are essential for reducing microbial counts in the root canal system. However, these methods do not completely eliminate microorganisms. Intracanal medicaments are used to further decrease microbial counts. This study aims to assess the cytotoxicity of various intracanal medicaments.</p><p><strong>Materials and methods: </strong>In this in vitro study, murine fibroblast cell lines (L929) were cultured in a controlled environment. The MTT assay was employed to evaluate the cytotoxicity of different medicament combinations, including calcium hydroxide and triamcinolone (D1), niosomal doxycycline and triamcinolone (D2), calcium hydroxide (D3), and a combination of doxycycline and triamcinolone (D4). Statistical analysis was performed using ANOVA and Dunnett's test.</p><p><strong>Results: </strong>The results indicated that D1 and D2 had lower cytotoxicity, while D4 exhibited the highest cytotoxicity. D1 was found to be non-cytotoxic up to a concentration of 500 µg/mL over a period of 72 hours. D2 and D3 showed similar effects up to concentrations of 250 µg/mL and 100 µg/mL, respectively, for 72 hours. In contrast, D4 exhibited cytotoxicity at concentrations above 75 µg/mL at 72 hours.</p><p><strong>Conclusion: </strong>This study suggests that encapsulating doxycycline in niosomal structures (D2) reduces cytotoxicity in murine fibroblast cell lines (L929) for at least 24 and 48 hours. These findings offer promising implications for the development of endodontic medicaments with improved biocompatibility.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 1","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10787185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guided Endodontic Treatment of Mandibular Incisor with Pulp Canal Obliteration following Dental Trauma: A Case Report.","authors":"Henry Paul Valverde Haro, Luis Gustavo Quille Punina, Adriana Denisse Erazo Conde","doi":"10.22037/iej.v19i3.45123","DOIUrl":"10.22037/iej.v19i3.45123","url":null,"abstract":"<p><p>Root canal obliteration is caused by hard tissue apposition and is often associated with teeth with a history of trauma, orthodontic movement, caries reaction, restorative procedures near the pulp chamber, and teeth of elderly patients. Preoperative planning of root canal treatment should be thorough and include an assessment of the patient's signs and symptoms in addition to the evaluation of complementary examinations. In a 27-year-old patient with dyschromia of the lower central incisor, a history of dental trauma, and a positive response to vertical percussion, an initial periapical radiograph was obtained that showed calcification of the canal and presence of a periapical lesion. The patient presented with pain on chewing, a positive response to palpation and a vertical percussion test. The diagnosis was symptomatic apical periodontitis. A cone-beam computed tomography scan was requested and a surface scan was performed to establish a static guide. The root canal was accessed in the middle third of the root and the canal was located using a minimally invasive approach. The root canal was treated conventionally. Results obtained showed the success of the treatment after a 3-year clinical and radiographic follow-up. Therefore, the use of an endodontic guide in cases of calcified canals significantly reduces the clinician's working time and offers a more predictable approach to the treatment of these pathologies.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 3","pages":"223-227"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revascularization of a Previously Treated Mandibular First Molar with Open Apices: A Case Report.","authors":"Mojgan Feli, Anita Taheri, Mahgol Mehrabani","doi":"10.22037/iej.v19i2.43321","DOIUrl":"https://doi.org/10.22037/iej.v19i2.43321","url":null,"abstract":"<p><p>In this case report, the regeneration method was used to treat the previously treated first molar, which presented with symptoms of pain during chewing and secondary acute apical periodontitis. Due to the importance of preserving the patient's permanent teeth in order to maintain optimal space and function, the regeneration treatment was performed in two visits and according to the American Association of Endodontists (AAE) guidelines. The continuation of tooth root development, healing of periapical radiolucency and positive response to sensibility test (cold test) were observed during follow-up radiographs at intervals of 6 months, 1 year & 2 year.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 2","pages":"120-123"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10988637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propolis-enhanced Calcium Hydroxide Combination for Direct Pulp Capping: Impact on Oxidative Stress Markers in Wistar Rat Teeth.","authors":"Ira Widjiastuti, Sri Kunarti, Evri Kusumah Ningtyas, Ayu Rafania Atikah, Khadijah Fauzi Basalamah, Amelia Evita Puspita, Novelia Ayu Widianti, Tengku Natasha Eleena Binti Tengku Ahmad Noor","doi":"10.22037/iej.v19i2.42269","DOIUrl":"https://doi.org/10.22037/iej.v19i2.42269","url":null,"abstract":"<p><strong>Introduction: </strong>This study explored the effects of propolis extract calcium hydroxide (Ca(OH)₂) combination on malondialdehyde and superoxide dismutase expression in dental pulp, aiming to assess its potential as a direct pulp capping material.</p><p><strong>Materials and methods: </strong>Thirty male Wistar rats were randomly assigned to three groups. Mandibular molar teeth were prepared using a low-speed round bur. In Group I, no material was applied; in Group II, teeth were treated with Ca(OH)₂; and in Group III, teeth were treated with Propolis extract-Ca(OH)₂, followed by Cention N filling. Immunohistochemistry was conducted on pulp tissue samples obtained on the third and seventh days post-treatment to assess malondialdehyde and superoxide dismutase expression. Statistical analyses included the Shapiro-Wilk test, Levene test, ANOVA, and Tukey's HSD.</p><p><strong>Results: </strong>The samples treated with propolis extract-Ca(OH)₂ combination exhibited significantly lower malondialdehyde expression on both days compared to samples treated with Ca(OH)₂ (<i>P</i><0.05), indicating reduced oxidative stress. Superoxide dismutase expression in the propolis extract-Ca(OH)₂ group was higher (<i>P</i><0.05), suggesting an enhanced antioxidant activity. The control group showed intermediate results. Statistical analyses confirmed significant differences between groups for both malondialdehyde and superoxide dismutase expressions (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>The study suggests that the propolis extract-Ca(OH)₂ combination holds promise for direct pulp capping applications by minimizing oxidative stress and promoting antioxidant defense mechanisms in dental pulp.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 2","pages":"99-104"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10988644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}