İstanbul Journal of Pharmacy最新文献_第2页

Synthesis, Characterization, Antibacterial and Antifungal Evaluation of Novel Cyclohexanone Benzoylhydrazones 新型环己酮苯甲酰腙的合成、表征及抑菌抑菌评价

İstanbul Journal of Pharmacy Pub Date : 2019-12-01 DOI: 10.26650/istanbuljpharm.2019.19022

Gökçe Cihan-Üstündağ, Emel Mataracı-Kara, G. Çapan

引用次数: 2

Determination of Pharmacy Pharmacists and Pharmacy Employees' Knowledge and Attitudes about Magistral Drug Preparation in Malatya/Turkey 土耳其马拉提亚地区药房药师和药房员工对主药制剂知识和态度的调查

İstanbul Journal of Pharmacy Pub Date : 2019-12-01 DOI: 10.26650/istanbuljpharm.2019.19012

Turgay Kolaç, P. Gürbüz, Gülsüm Yetiş, Z. Çirak

{"title":"Determination of Pharmacy Pharmacists and Pharmacy Employees' Knowledge and Attitudes about Magistral Drug Preparation in Malatya/Turkey","authors":"Turgay Kolaç, P. Gürbüz, Gülsüm Yetiş, Z. Çirak","doi":"10.26650/istanbuljpharm.2019.19012","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.19012","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19012 Magistral drugs are preferred when present preparations are not sufficient. Even though , the tendency of their usage ha d been decreased , it is predicted that magistral applications will be used more often in the future. In this study pharmacists and pharmacy emplo yees, who work in 95 pharmacies in Malatya city center and accepted to join the study (n=203 ), filled a questionnaire which was prepared by using the literature. In the analysis of the obtained data, frequency and percentages were calculated by using SPSS 24.0 program. It was observed that 11.1 of the pharmacies were close to a health center and 88.0 of the participants were preparing magistral drugs. It was stated that 55.2 of the participants prepared magistral medications 1 2 times a week According to the results, although the frequency varied with the localization of pharmacies, magistral drug preparation ratios w ere generally similar with the literature. Preferred magistral drug forms were; cream (74.7 %%), pomade (69.8 and solution (54.7 in order. Of the participants who stated themselves to be insufficient in magistral drug preparation 19.5 said that the p rescriptions were insufficient and 33.3 reported that the doctors' prescriptions were incomplete or unreadable. You may cite this article as : Kolac T, Gurbuz P, Yetis G, Cirak ZD (2019). Determination of Pharmacy Pharmacists and Pharmacy Employees' Knowledge and Attitudes about Magistral Drug Preparation in Malatya/Turkey. Istanbul J Pharm 10.26650/IstanbulJPharm.2019.19012.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81897960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Cytotoxicity and Insecticidal Activity of Extracts from Delphinium formosum Boiss. & Huet 台湾飞燕草提取物的细胞毒性和杀虫活性。& Huet

İstanbul Journal of Pharmacy Pub Date : 2019-12-01 DOI: 10.26650/istanbuljpharm.2019.19034

B. Sen-Utsukarci, N. Tabanca, A. Estep, Ozlem Akbal-Dagistan, S. Kessler, Z. Ozturk, J. Becnel, A. Kiemer, A. Mat

{"title":"The Cytotoxicity and Insecticidal Activity of Extracts from Delphinium formosum Boiss. & Huet","authors":"B. Sen-Utsukarci, N. Tabanca, A. Estep, Ozlem Akbal-Dagistan, S. Kessler, Z. Ozturk, J. Becnel, A. Kiemer, A. Mat","doi":"10.26650/istanbuljpharm.2019.19034","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.19034","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19034 Delphinium species are well-known toxic plants with their diterpenoid alkaloid contents. There has been no previous investigation on the cytotoxicity of Delphinium formosum Boiss. & Huet. The extracts of the different parts of D. formosum, an endemic species in Turkey, were investigated for their cytotoxic activity against the human liver carcinoma cell line (HepG2) and primary human umbilical vein endothelial cells (HUVEC). The cytotoxic effects of twelve extracts and subfractions were determined against HepG2 cells using MTT assay. The only active extract was applied to the HUVEC as a model for healthy cells. Only one of the alkaloid-containing extracts from the aerial parts was toxic (IC50 = 244,9 μg/mL against HepG2 and 144,4 μg/mL against HUVEC), while the root extracts were inactive. The results were improbable although it’s predicted secondary metabolites, such as diterpene alkaloids (methyllycaconitine, browniine, lycoctonine, avardharidine, antranoyllycoctonine, delsemine A/B and lycoctonine). Based on previous studies in literature, the cytotoxic plants were also expected to exhibit insecticidal activity. Therefore, the cytotoxic extract of D. formosum was examined for its adulticidal and larvicidal activity against the yellow fever, dengue fevers and Zika virus vector Aedes aegypti L. You may cite this article as : Sen-Utsukarci B, Tabanca N, Estep AS, Akbal-Dagistan O, Kessler SM, Ozturk Z, Becnel J, Kiemer AK, Mat A (2019). The Cytotoxicity and Insecticidal Activity of Extracts from Delphinium formosum Boiss. & Huet. Istanbul J Pharm 10.26650/IstanbulJPharm.2019.19034.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91063192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Paclitaxel and Flurbiprofen Co-Loaded PLGA Nanoparticles: Understanding Critical Formulation and Process Parameters Using Plackett–Burman Design 紫杉醇和氟比洛芬共载PLGA纳米颗粒的研制:利用Plackett-Burman设计了解关键配方和工艺参数

İstanbul Journal of Pharmacy Pub Date : 2019-12-01 DOI: 10.26650/istanbuljpharm.2019.19036

A. Sahin, Secil Caban-Toktas, H. Tonbul, F. Yerlikaya, Y. Aktaş, Y. Capan

{"title":"Development of Paclitaxel and Flurbiprofen Co-Loaded PLGA Nanoparticles: Understanding Critical Formulation and Process Parameters Using Plackett–Burman Design","authors":"A. Sahin, Secil Caban-Toktas, H. Tonbul, F. Yerlikaya, Y. Aktaş, Y. Capan","doi":"10.26650/istanbuljpharm.2019.19036","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.19036","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19036 Nano drug co-delivery system is a popular strategy for combined application of two or more anticancer and/or synergistic drugs. Synergistic effects of nonsteroidal anti-inflammatory drugs and anti-cancer drugs in cancer treatment are shown in the literature. In this study, it was aimed to screen and understand critical formulation and process parameters inthe preparationflurbiprofen and paclitaxel co-loaded nanoparticles for developing an anti-cancer nano co-delivery system. With this aim, critical parameters were determined using Plackett–Burman experimental design (DoE). Flurbiprofen and paclitaxel drug loading amounts were considered as critical quality attributes to controleffective drug loading ratio. Furthermore, average particle size and zeta potential were also defined as critical quality attributes in order to optimize passive drug targeting and colloidal stability. Surfactant type was determined as the most significant factors for the average particle size and zeta potential. For flurbiprofen and paclitaxel drug loading into the nanoparticles, amounts of both flurbiprofen and paclitaxel were determined as critical factors. Consequently, paclitaxel and flurbiprofen were efficiently loaded into nanoparticles and the impact of the formulation variables were successfully screened by a DoE. By controlling the determined parameters, therapeutic efficacy of co-loaded drug nanoparticles could be maximized in further studies. You may cite this article as : Şahin A, Caban-Toktas S, Tonbul H, Yerlikaya F, Aktas Y, Capan Y (2019). Development of Paclitaxel and Flurbiprofen Co-Loaded PLGA Nanoparticles: Understanding Critical Formulation and Process Parameters Using Plackett–Burman Design. Istanbul J Pharm 10.26650/IstanbulJPharm.2019.19036.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85147084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

In vitro evaluation of Rheum ribes induced genotoxicity in HepG2 cell lines 大黄对HepG2细胞株遗传毒性的体外评价

İstanbul Journal of Pharmacy Pub Date : 2019-12-01 DOI: 10.26650/istanbuljpharm.2019.19021

Mahmoud Abudayyak

{"title":"In vitro evaluation of Rheum ribes induced genotoxicity in HepG2 cell lines","authors":"Mahmoud Abudayyak","doi":"10.26650/istanbuljpharm.2019.19021","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.19021","url":null,"abstract":"Rheum ribes is a perennial herbaceous plant belonging to the Polygonaceae family that grows more in rocky and gravelly slopes in high altitude areas of Levant and Turkey. Rheum ribes is consumed as food and widely used in folk medicine against nausea, constipation and for different diseases including diabetesand hypertension. Unfortunately, the researches on Rheum ribes toxicity are insufficient. In our study, human hepatocellular carcinoma (HepG2) cell line was used in cytotoxicity evaluation of Rheum ribes water, methanol and chloroform extracts by MTT and NRU test. Comet assay was used to investigate the genotoxicity potentials of the plant extracts. Our results show that all extracts cause cell death in a concentration dependent manner at 5-50 mg/mL concentrations. The IC50 values are 14.29- 31.94 mg/mL by MTT and 21.15 - 27.66 mg/mL by NRU assay. The highest concentration (25 mg/mL) of methanol extract causes a significant DNA damage (8.7-folds). In conclusion, similar to a lot of plants used in the folk medicine the risk of Rheum ribes is still unknown. The uncontrolled use of this plant could harm to the patients. Our results indicate possible cyto- and gentoxicity effects of Rheum ribes, these results should rise the concerns about the safety of Rheum ribes and other folk herbs. Cite this article as : Abudayyak M (2019). In vitro evaluation of Rheum ribes induced genotoxicity in HepG2 cell lines. Istanbul J Pharm 10.26650/IstanbulJPharm.2019.19021.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77550117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Bismuth Oxide Nanoparticles Induced Oxidative Stress-Related Inflammation in SH-SY5Y Cell Line 氧化铋纳米颗粒诱导SH-SY5Y细胞氧化应激相关炎症

İstanbul Journal of Pharmacy Pub Date : 2019-12-01 DOI: 10.26650/istanbuljpharm.2019.19020

E. Oztas, Mahmoud Abudayyak, Beyza Aykanat, Zubeyde Can, E. Baram, G. Özhan

{"title":"Bismuth Oxide Nanoparticles Induced Oxidative Stress-Related Inflammation in SH-SY5Y Cell Line","authors":"E. Oztas, Mahmoud Abudayyak, Beyza Aykanat, Zubeyde Can, E. Baram, G. Özhan","doi":"10.26650/istanbuljpharm.2019.19020","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.19020","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19020 Bismuth (III) oxide nanoparticles’ (Bi2O3-NPs) unique physicochemical properties attracted the attention in biological, industrial, technological and medical fields. Concurrently, increasing numbers of studies revealing their potential toxic effects and possible toxicity mechanisms are ongoing. In this study, we assessed the toxic potentials of Bi2O3-NPs in human SH-SY5Y neuroblastoma cell line. After Bi2O3-NPs characterization using TEM, the cytotoxic potentials were evaluated by MTT and LDH assays. The induction of reactive oxygen species production was evaluated by H2DCFDA. In order to evaluate the oxidative damages, the changes in antioxidant catalase and superoxide dismutase and glutathione levels were determined. The cellular death pathway and the role of immune response were studied by measuring the mRNA expression levels of related genes. Our results showed that Bi2O3-NPs decreased the cell viability through disruption on mitochondrial activity (IC50:77.57 μg/mL) and membrane integrity (LDH%50:16.97 μg/mL). At 50 μg/mL Bi2O3-NPs, the production of reactive oxygen species (ROS) was induced significantly as well as the catalase and superoxide dismutase levels. In immune response, the mRNA expression levels of interleukin (IL)-6 were increased more than 1.5-fold in all doses; whereas, TNF-α, NF-ĸB and MAPK8 expressions were remained unchanged. Consequently, Bi2O3-NPs induced oxidative stress-related inflammation via activation of pro-inflammatory cytokine, IL-6. You may cite this article as : Oztas E, Abudayyak M, Aykanat B, Can Z, Baram E, Ozhan G (2019). Bismuth Oxide Nanoparticles Induced Oxidative Stress-Related Inflammation in SH-SY5Y Cell Line. Istanbul J Pharm 10.26650/IstanbulJPharm.2019.19020.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82284828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation 枸杞体外多个药理靶点的研究。抗与神经退行性疾病、糖尿病和色素沉着相关的关键酶

İstanbul Journal of Pharmacy Pub Date : 2019-10-11 DOI: 10.5152/ISTANBULJPHARM.2018.396764

S. Uysal, R. Ceylan, A. Aktumsek, G. Guler, C. M. N. Picot, G. Zengin, M. Mahomoodally

{"title":"In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa\u0000 against key enzymes linked to neurodegenerative diseases, diabetes, and\u0000 hyperpigmentation","authors":"S. Uysal, R. Ceylan, A. Aktumsek, G. Guler, C. M. N. Picot, G. Zengin, M. Mahomoodally","doi":"10.5152/ISTANBULJPHARM.2018.396764","DOIUrl":"https://doi.org/10.5152/ISTANBULJPHARM.2018.396764","url":null,"abstract":"DOI : 10.5152/IstanbulJPharm.2018.396764 Prevention and treatment of noncommunicable diseases such as neurodegenerative diseases, diabetes, and hyperpigmentation using medicinal plants has attracted increasing attention during the past few decades. In this study, Colutea cilicica Boiss. & Balansa extracts (ethyl acetate, methanol, and water) were evaluated against key enzymes involved in neurodegenerative diseases, diabetes, and hyperpigmentation. The antioxidant (free radical scavenging, reducing power, β-carotene/linoleic acid, and phosphomolybdenum) and metal chelation properties were also investigated. The methanol extracts of C. cilicica vigorously inhibited the activities of acetylcholinesterase and butyrylcholinesterase (1.33 and 0.68 mg galantamine equivalents (GALAE)/g extract, respectively). It was observed that C. cilicica extracts possessed a higher inhibitory potential for α-glucosidase (2.71–1.23 mmol acarbose equivalents (ACAE)/g extract) than that for α-amylase (0.57–0.12 mmol ACAE/g extract). The water extract of C. cilicica showed potent radical scavenging capacity against DPPH (2, 2-diphenyl-1-picrylhydrazyl) and ABTS (2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (42.46 and 57.70 mg trolox equivalents (TE)/g extract, respectively). Phytochemical determination showed that C. cilicica water extract (17.26 mg rutin equivalents (RE)/g extract) was rich in flavonoids compared with ethyl acetate and methanol extracts (2.78 and 2.83 mg RE/g extract, for the respective extracts). These findings reveal the interesting potential of C. cilicica as a valuable source of phytochemicals that can be used against common noncommunicable diseases, particularly against enzymes involved in neurodegenerative diseases.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72608473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of biorelevant media to investigate the dissolution properties on flurbiprofen and to assess cytotoxicity effects on Caco-2 cell line 评价生物相关介质对氟比洛芬的溶出特性及对Caco-2细胞株的细胞毒性作用

İstanbul Journal of Pharmacy Pub Date : 2019-10-11 DOI: 10.26650/ISTANBULJPHARM.2018.180013

Diren Sarısaltık Yaşın, S. Yılmaz, Z. Teksin

{"title":"Evaluation of biorelevant media to investigate the dissolution properties on flurbiprofen and to assess cytotoxicity effects on Caco-2 cell line","authors":"Diren Sarısaltık Yaşın, S. Yılmaz, Z. Teksin","doi":"10.26650/ISTANBULJPHARM.2018.180013","DOIUrl":"https://doi.org/10.26650/ISTANBULJPHARM.2018.180013","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2018.180013 Biorelevant media are used to simulate the physiological conditions in terms of components, pH, osmolality and buffer capacity of the human stomach and intestine in both fasted and fed states In this study, we aim to apply the biorelevant media to Caco-2 cell lines to investigate the cytotoxicity effects via the cell viability ratio and to compare the solubilizing effects of various dissolution media on a poorly soluble model drug. Flurbiprofen (Biopharmaceutics Classification System, BCS Class 2) was selected as a model drug. In dissolution studies the pH effects were predominant at higher pH values, while bile salt effects were dominant at lower pH values. The preparation method, bile salts and the phospholipids did not show any additional effect on Caco-2 cell viability. In the cytotoxicity test, fed state media caused an additional 10-15% decrease in cell viability, compared to the fasted state. Similar results were obtained when using the blank of these media which did not include the bile salt or phospholipid. From this, it is evident that this decrease resulted from the pH values, not the components. In conclusion, the cytotoxicity assessment showed that all the biorelevant media were compatible with 70-90% of cell viability for at least 24 h, and this ratio might be increased by modifying the pH.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90816816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Leaf indumentum in some Turkish species of Teucrium (Lamiaceae) 土耳其几种茶属植物的叶被

İstanbul Journal of Pharmacy Pub Date : 2019-10-11 DOI: 10.5152/ISTANBULJPHARM.2018.374759

Gülay Ecevit-Genç, T. Özcan, T. Dirmenci

{"title":"Leaf indumentum in some Turkish species of Teucrium (Lamiaceae)","authors":"Gülay Ecevit-Genç, T. Özcan, T. Dirmenci","doi":"10.5152/ISTANBULJPHARM.2018.374759","DOIUrl":"https://doi.org/10.5152/ISTANBULJPHARM.2018.374759","url":null,"abstract":"DOI : 10.5152/IstanbulJPharm.2018.374759 Trichome micromorphology can be used as a discriminating character in the separation of species and subspecies. The micromorphological characteristics of foliar trichomes from five Teucrium taxa (T. scordium subsp. scordium, T. sirnakense, T. chasmophyticum, T. andrusi and T. spinosum) were investigated by scanning electron microscope. Seven types of trichomes were identified, including glandular and non-glandular. The glandular trichomes were recorded in three types; short clavate, long clavate, and subsessile. The non-glandular trichomes were identified with four types; unicellular thin-walled, 2(5)-celled thin-walled, 3–7(11)-celled flexuose, elongated thin-walled and 2-celled thick-walled trichomes. Generally, the trichome types were similar on both sides of the leaves, except in T. spinosum. Subsessile glandular trichomes were the most common type and were occurred in all the investigated species. Also clavate glandular trichomes were found in all the species, except T. scordium subsp. scordium. All trichomes were distinctively thick-walled, whereas thin-walled trichomes were observed in only T. chasmophyticum species. The leaf micromorphology of T. sirnakense and T. chasmophyticum has also been reported in detail for the first time in this study.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75176538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Anticancer activities and cell death mechanisms of 1H-indole-2,3-dione 3-[N-(4 sulfamoylphenyl)thiosemicarbazone] derivatives h -吲哚-2,3-二酮3-[N-(4磺胺基苯基)硫代氨基脲]衍生物的抗癌活性和细胞死亡机制

İstanbul Journal of Pharmacy Pub Date : 2019-10-11 DOI: 10.26650/ISTANBULJPHARM.2018.414805

İ. Çetin, Pınar Eraslan Elma, M. Topcul, N. Karalı

引用次数: 1