h -吲哚-2,3-二酮3-[N-(4磺胺基苯基)硫代氨基脲]衍生物的抗癌活性和细胞死亡机制

İ. Çetin, Pınar Eraslan Elma, M. Topcul, N. Karalı
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引用次数: 1

摘要

在本研究中,利用细胞动力学参数,包括细胞指数、有丝分裂指数、标记指数和凋亡指数,评估了1h -吲哚-2,3-二酮3-[N-(4-磺胺基苯基)硫代氨基脲衍生物(4a-d)对人宫颈癌HeLa细胞的细胞毒性作用。用5、10、20、40、80、100和160 μM浓度下的细胞指数参数对所有化合物进行评价。由此可见,所有的4 -d化合物在不同浓度下都是有效的。不同的细胞死亡机制提出了4 -d。当检查所有参数时,发现溴取代的4c是在所测试化合物中最有效的抗增殖化合物。对照组与试验组间差异有统计学意义(p<0.01)。各实验组间差异有统计学意义(p<0.01)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anticancer activities and cell death mechanisms of 1H-indole-2,3-dione 3-[N-(4 sulfamoylphenyl)thiosemicarbazone] derivatives
DOI: 10.26650/IstanbulJPharm.2018.414805 In this study, the cytotoxic effects of 1H-indole-2,3-dione 3-[N-(4-sulfamoylphenyl)thiosemicarbazone derivatives namely, 4a-d were evaluated using cell kinetic parameters including the cell index, mitotic index, labelling index and apoptotic index on HeLa cells taken from a human cervix carcinoma. All compounds were evaluated using cell index parameters at 5, 10, 20, 40, 80, 100 and 160 μM concentrations. As a result of this, it was seen that all 4a-d compounds were effective in different concentrations. Different cell death mechanisms were proposed for 4a-d. When all the parameters were examined, it was found that the bromine substituted 4c was the most potent antiproliferative compound in the tested compounds. The difference was significant between the control and experimental groups (p<0.01). In addition, a statistically significant difference was noted among all experimental groups (p<0.01).
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