İstanbul Journal of Pharmacy最新文献_第3页

Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis 两种商业黑皮籽油的生物学、植物化学和物理化学性质:比较分析

İstanbul Journal of Pharmacy Pub Date : 2019-10-11 DOI: 10.26650/ISTANBULJPHARM.2018.180003

M. Z. Aumeeruddy, Z. Aumeeruddy-Elalfi, H. Neetoo, G. Zengin, B. Fibrich, S. Rademan, A. B. V. Staden, K. Szuman, I. Lambrechts, N. Lall, M. Mahomoodally

{"title":"Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis","authors":"M. Z. Aumeeruddy, Z. Aumeeruddy-Elalfi, H. Neetoo, G. Zengin, B. Fibrich, S. Rademan, A. B. V. Staden, K. Szuman, I. Lambrechts, N. Lall, M. Mahomoodally","doi":"10.26650/ISTANBULJPHARM.2018.180003","DOIUrl":"https://doi.org/10.26650/ISTANBULJPHARM.2018.180003","url":null,"abstract":"This study was designed to evaluate and correlate the biological, phytochemical, and physicochemical properties of two NSS (Nigella sativa seed) oils (N1 and N2). The biological activity was evaluated in terms of antibacterial, antioxidant (nitric oxide scavenging), antielastase, antityrosinase, antimelanogenic, and anticancer activity. Physicochemical properties including colour, total soluble solids (TSS), and density were also investigated. N2 exhibited higher antibacterial, NO scavenging, extracellular antimelanogenic, and anticancer activity against the HeLa cell line compared to N1, which showed higher antityrosinase activity. TPC (total phenolic content) and TFC (total flavonoid content) of N1 were significantly higher than N2 while TTC (total tannin content) was higher in N2. In fact, TTC was strongly correlated (R=1.000) with the antioxidant, extracellular antimelanogenic, and HeLa cell inhibitory activity. To conclude, NSS oil may be considered as a complementary and alternative therapy in the management of infectious and chronic diseases but warrants further in vivo pharmacological validation and toxicological analysis.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75281778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Ceragenins exhibiting promising antimicrobial activity against various multidrug resistant Gram negative bacteria 对多种多重耐药革兰氏阴性菌具有良好的抗菌活性

İstanbul Journal of Pharmacy Pub Date : 2019-10-11 DOI: 10.26650/ISTANBULJPHARM.2018.400730

Ozlem Oyardi, P. Savage, Alper Akçalı, Z. Erturan, C. Bozkurt-Guzel

引用次数: 2

The anatomical properties of Scabiosa atropurpurea L. (Caprifoliaceae) 杏叶卡皮草(capriaceae)的解剖性质

İstanbul Journal of Pharmacy Pub Date : 2019-10-11 DOI: 10.5152/ISTANBULJPHARM.2018.376278

Y. Yeşil, Zeynep Büşra Erarslan

{"title":"The anatomical properties of Scabiosa atropurpurea L. (Caprifoliaceae)","authors":"Y. Yeşil, Zeynep Büşra Erarslan","doi":"10.5152/ISTANBULJPHARM.2018.376278","DOIUrl":"https://doi.org/10.5152/ISTANBULJPHARM.2018.376278","url":null,"abstract":"DOI : 10.5152/IstanbulJPharm.2018.376278 Scabiosa atropurpurea L. (Caprifoliaceae), a medicinal plant traditionally known as “Mor uyuzotu or Şeytanotu” in Turkey, has been used for treating acne, bronchitis, cold, and cough. Although phytochemical studies are available, there are no taxonomic studies related to this plant. The aim of this study was to investigate the anatomy of leaf, stem, and root of S. atropurpurea. Detailed photographs of plant parts were taken, and measurements of the leaf, stem, and root were carried out. The cross section of the stem revealed a single-layered epidermis containing one-celled simple eglandular trichomes and rarely one-celled hook-shaped eglandular trichomes. The cortex showed multilayered parenchymatous cells and a single-layered endodermis. The phloem was followed by the cambium, and the xylem was lignified. The pith was made up of parenchymatous cells. The leaves are bifacial and amphistomatic and stomata are mesomorphic in the cross section and also stomata are anomocytic in the surface section. The cross section of the root showed that the epidermis was replaced with the periderm. Under the phloem, which had few layers, the xylem was composed of tracheary elements surrounded with sclerenchymatous cells.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81620078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Purification and partial characterization of thioredoxin reductase from the hepatopancreas of the mollusc Mytilus galloprovincialis Lam. 紫贻贝肝胰脏硫氧还蛋白还原酶的纯化及部分性质。

İstanbul Journal of Pharmacy Pub Date : 2019-10-11 DOI: 10.5152/ISTANBULJPHARM.2018.382627

E. Acar, Gozde Hasbal, N. Ozsoy

{"title":"Purification and partial characterization of thioredoxin reductase from the\u0000 hepatopancreas of the mollusc Mytilus galloprovincialis Lam.","authors":"E. Acar, Gozde Hasbal, N. Ozsoy","doi":"10.5152/ISTANBULJPHARM.2018.382627","DOIUrl":"https://doi.org/10.5152/ISTANBULJPHARM.2018.382627","url":null,"abstract":"DOI : 10.5152/IstanbulJPharm.2018.382627 Thioredoxin reductase (TrxR, EC 1.6.4.5) is a ubiquitous flavoenzyme that is present from Archaea to humans, and it is the only enzyme capable of catalyzing the reduction of thioredoxin (Trx) by nicotinamide adenine dinucleotide phosphate (NADPH). Although TrxR has been purified and characterized from different bacteria, plants, and mammalian organisms, a survey of the literature revealed no studies on the purification and characterization of TrxR from the mussel Mytilus galloprovincialis Lam. In this study, TrxR was purified to homogeneity from the hepatopancreatic tissue of M. galloprovincialis Lam. by extraction, ammonium sulfate precipitation, and DEAE-Sepharose CL-6B anion and 2’,5‘-ADP-agarose chromatographies, and some of its kinetic properties were examined. Molar mass determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis revealed only a single protein band corresponding to a molecular weight of 35 kDa. Optimum pH and temperature were found to be 7.0 and 60°C, respectively. Km and Vmax values for NADPH were found to be 85 µmol and 4.82 µmol/min/mg, respectively. For 5,5ʹ-dithiobis (2-nitrobenzoic) acid (DTNB), the Km and Vmax values were 193 µmol and 1.32 µmol/min/mg, respectively. Increasing the knowledge on the kinetic properties of TrxR will significantly increase the prospects of enzyme application as an oxidative stress biomarker in mussels and fishes for monitoring contamination in coastal environments.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85789657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, characterization and biological activity studies on amide derivatives 酰胺类衍生物的合成、表征及生物活性研究

İstanbul Journal of Pharmacy Pub Date : 2019-10-11 DOI: 10.26650/ISTANBULJPHARM.2018.18007

S. Türk, K. Turan, S. Ulusoy, S. Karakuş, G. Boşgelmez-Tinaz

引用次数: 0

Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS 葛兰的生物碱谱分析。通过气相色谱/质谱分析

İstanbul Journal of Pharmacy Pub Date : 2019-10-11 DOI: 10.26650/ISTANBULJPHARM.2018.422525

Ç. Karakoyun

引用次数: 0

Design, synthesis, and evaluation of antitubercular activity of a novel benzothiazole-containing an azetidinone ring 一种新型含氮杂环苯并噻唑抗结核活性的设计、合成和评价

İstanbul Journal of Pharmacy Pub Date : 2019-10-09 DOI: 10.5152/ISTANBULJPHARM.2018.320135

S. Sarkar

{"title":"Design, synthesis, and evaluation of antitubercular activity of a novel benzothiazole-containing an azetidinone ring","authors":"S. Sarkar","doi":"10.5152/ISTANBULJPHARM.2018.320135","DOIUrl":"https://doi.org/10.5152/ISTANBULJPHARM.2018.320135","url":null,"abstract":"DOI: 10.5152/IstanbulJPharm.2018.320135 Recent studies have demonstrated that 2-amino-substituted benzothiazole derivatives exhibit significant antitubercular activity. In this study, new compounds of benzothiazole-containing azetidinone derivatives were designed and synthesized using substituted benzaldehydeN-(5fluoro-1,3-benzothiazol-2-yl) semicarbazone, chloroacetyl chloride, and triethylamine in DMF. The structures of the synthesized compounds were characterized by TLC, IR, elemental analysis, and 1H NMR. In vitro screening data revealed that all the designed and synthesized compounds A6–A10 exhibited the ability to inhibit the growth of Mycobacterium tuberculosis in terms of MIC. Variable and modest activity was observed against the investigated strains of bacteria; however, the compound A6 exhibited significant antitubercular activity against M. tuberculosis H37Rv (MTCC 200) compared to that of the reference drugs isoniazid and rifampicin. These experimental data were consistent with our computational predictions in terms of the compound A6 that exhibited a satisfactory backbone for the antitubercular activity, perhaps due to an increase in hydrophobicity resulting in better penetration through the cell wall of M. tuberculosis.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78049261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A validated method without derivatization for the determination of Letrozole by high performance liquid chromatography-fluorimetric method for pharmaceutical preparation 一种经验证的药物制剂用高效液相色谱-荧光法测定来曲唑的无衍生化方法

İstanbul Journal of Pharmacy Pub Date : 2019-10-09 DOI: 10.5152/ISTANBULJPHARM.2018.397094

Cem Kaplan, D. Unal

引用次数: 2

Plants used as painkillers in folk medicine in Turkey IV – TOOTHACHE 土耳其民间医药中用作止痛药的植物IV -牙痛

İstanbul Journal of Pharmacy Pub Date : 2019-10-09 DOI: 10.5152/ISTANBULJPHARM.2018.412321

Meryem Seyda Erbay, S. Anıl, G. Melikoğlu

{"title":"Plants used as painkillers in folk medicine in Turkey IV – TOOTHACHE","authors":"Meryem Seyda Erbay, S. Anıl, G. Melikoğlu","doi":"10.5152/ISTANBULJPHARM.2018.412321","DOIUrl":"https://doi.org/10.5152/ISTANBULJPHARM.2018.412321","url":null,"abstract":"DOI : 10.5152/IstanbulJPharm.2018.412321 Turkey has a rich plant diversity due to its geography and many of these plants are used in the treatment of various diseases. The usage of these medicinal plants has been passed down from generation to generation. Ethnobotanical studies are used to record traditional treatment methods and this information is intended to contribute to drug development studies. This study (which is the fourth article in a series focusing on plants with painkilling properties) details the plants used to combat toothache. In this survey, which was prepared by screening ethnobotanical research, a total of 52 taxa were traditionally used in toothache treatment in Turkey. Scientific and local names, families, parts used, and treatment methods of these plants were recorded. According to the results of the research, the most common families are Lamiaceae, Asteraceae, Solanaceae, Euphorbiaceae, Liliaceae and Rosaceae. The most commonly used taxa in different regions of Turkey are Cornus mas, Dianthus zonatus var. zonatus and Hyocyamus niger. These plants contain analgesic and anti-inflammatory compounds. These plants are usually used externally as extracts (infusion/decoction) as well as are used directly. However, a few species are also used externally.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89738424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Overview on nanotechnology based cosmeceuticals to prevent skin aging 以纳米技术为基础的药妆预防皮肤老化概述

İstanbul Journal of Pharmacy Pub Date : 2019-10-09 DOI: 10.5152/ISTANBULJPHARM.2018.424278

Gizem Otlatıcı, Gizem Yeğen, S. Güngör, B. Aksu

{"title":"Overview on nanotechnology based cosmeceuticals to prevent skin aging","authors":"Gizem Otlatıcı, Gizem Yeğen, S. Güngör, B. Aksu","doi":"10.5152/ISTANBULJPHARM.2018.424278","DOIUrl":"https://doi.org/10.5152/ISTANBULJPHARM.2018.424278","url":null,"abstract":"DOI : 10.5152/IstanbulJPharm.2018.424278 Skin aging is an inevitable process and the highest contributing factor to this process is the effect of ultraviolet rays. However, nutrients, dry skin, smoking, hormones and gravity are also other important factors. Skin aging is classified as intrinsic (chronological) and extrinsic (photo-aging). Generally, in aged skin, effects such as thinning, loss of elasticity, spotting, wrinkles and sagging are observed. There are various approaches to preventing skin aging. The most widely used age combating substances in cosmeceuticals are kinetin, retinoids, sun filters, herbal ingredients (such as resveratrol, turmeric, and green tea), and antioxidants (such as alpha-tocopherol, ascorbic acid, coenzyme Q10 and lipoic acid). In recent years, these molecules have been formulated as nanosized carriers such as vesicular systems, polymeric and lipid nanoparticles, nanoemulsions, dendrimers, and fullerenes. Novel carrier systems have a lot of advantages when compared to conventional formulations. In this review, an overview of cosmetic, product-oriented solutions for skin aging is given and different approaches to combat aging are summarized.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86702292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9