International Ophthalmology最新文献

{"title":"Evaluation of periocular scars after blepharoplasty and external dacryocystorhinostomy according to Manchester and modified Vancouver scar score.","authors":"Çisil Erkan Pota, Aslı Bilgiç, Aslı Çetinkaya Yaprak, Hatice Deniz İlhan, Uğur Kahraman","doi":"10.1007/s10792-025-03567-6","DOIUrl":"https://doi.org/10.1007/s10792-025-03567-6","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate and compare the scars of two groups of patients who underwent different periorbital surgical procedures, blepharoplasty and external dacryocystorhinostomy (DCR), using established scar scales. We aimed to compare the cosmetic outcomes of incisions parallel and perpendicular to the skin lines and to evaluate the relationship between patient satisfaction, skin aging, skin phototypes, and scar scores.</p><p><strong>Methods: </strong>This cross-sectional study included 55 patients who underwent upper eyelid blepharoplasty and 50 patients who underwent external DCR. Patients' postoperative scars were assessed between 12 and 36 months after surgery using the fitzpatrick skin type scoring (Type I white skin-Type VI dark brown/black skin), Modified Fitzpatrick Wrinkle Scale (MFWS) (Class 0 no wrinkle-Class 3 deep wrinkle), modified vancouver scar scale (MVSS) (pigmentation, vascularity, pliability, height) and the Manchester Scar Scale (MSS) (visual analog scale, color, matte/glossy, contour, distortion, texture) by an ophthalmologist and a dermatologist. The assessment was blinded. Finally, all participants answered a patient satisfaction scale consisting of three questions [(1) Can you see the wound (2) Is the scar important to you? (3) Would you undergo the same operation again regarding the scar?].</p><p><strong>Results: </strong>Both MSS and MVSS scores were higher in the blepharoplasty group than in the external DCR group (p = 0.041, p = 0.029). As patient dissatisfaction increased, a significant increase in both MSS and MVSS scoreswas observed (p = 0.001, r = 0.308; p = 0.025, r = 0.219).</p><p><strong>Conclusion: </strong>According to the patient satisfaction scale, blepharoplasty and external DCR were not significantly different, but external DCR resulted in less scarring than blepharoplasty according to MSS and MVSS (performed by a dermatologist and an ophthalmologist). We found that the scar score was influenced by the amount of wrinkles, but not by age or skin color. To our knowledge, this is the first study to compare both the MSS and MVSS scar scores with patient satisfaction after periocular surgery. Finally, both the MSS and MVSS scar scores provide an objective and useful method of assessing postoperative scarring and can therefore help surgical teams optimize their procedure and achieve a better outcome.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"190"},"PeriodicalIF":1.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cataract surgery on macular and peripapillary optical coherence tomography values.","authors":"Mona Pournaghi, Aidin Meshksar, Sadra Ashrafi, Kiana Hassanpour, Hossein Mohammad-Rabie, Shahin Yazdani, Bahareh Kheiri, Diba Idani, Farideh Sharifipour","doi":"10.1007/s10792-025-03557-8","DOIUrl":"https://doi.org/10.1007/s10792-025-03557-8","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of cataract surgery on peripapillary retinal nerve fiber layer (pp-RNFL) and macular thickness measurements, obtained by optical coherence tomography (OCT).</p><p><strong>Methods: </strong>In this prospective before-after study, both pp- and macular scans were obtained within two days before and then two weeks after surgery. Cataract density was graded using the Lens Opacities Classification System (LOCS) III. Pre- and postoperative quality scores and thicknesses were compared.</p><p><strong>Results: </strong>In 100 studied eyes of 100 patients, quality scores and thickness values increased postoperatively. (all P < 0.001). The greatest change was observed at the nasal superior sector of pp-OCT (5.28 ± 11.11µm) and the temporal quadrant of 3-mm-diameter circle (7.40 ± 9.13 µm) of macular scans. Changes in the quality score were significantly correlated with changes in global, nasal, and temporal-inferior pp-RNFL thicknesses and none of macular sectors. The greatest changes in pp-RNFL and macular thicknesses were observed with posterior subcapsular and the least with cortical cataracts. In 14 eyes, the increase in pp-RNFL thickness measurements resulted in a change in color display of pie charts. In this subset of patients, significant positive correlation was observed between global thickness change and quality change. (r = 0.217, P = 0.033).</p><p><strong>Conclusion: </strong>Cataract surgery significantly improves the quality score and thickness values of both pp- and macular OCT. Correcting OCT-derived pp-RNFL thicknesses in eyes with significant cataracts is needed to prevent misdiagnosis of glaucoma.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"189"},"PeriodicalIF":1.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating clues of cystoid macular edema from a vascular perspective under long-term latanoprost usage.","authors":"Cansu Yuksel Elgin, Ilayda Kaner Savci, Yildiz Birisik, Mustafa Hepokur","doi":"10.1007/s10792-025-03556-9","DOIUrl":"https://doi.org/10.1007/s10792-025-03556-9","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the macular vascular effects of prolonged use of latanoprost compared to the dorzolamide-timolol fixed combination in patients with very early-stage glaucoma, where glaucoma-specific damage has been minimized.</p><p><strong>Methods: </strong>The retinal vascular effects of latanoprost versus the dorzolamide-timolol fixed combination were evaluated using Optical Coherence Tomography Angiography (OCT-A) in a case-control study design. A total of 71 eyes from 71 individuals were included in the study: 28 eyes receiving latanoprost (Group 1), 20 eyes receiving the dorzolamide-timolol combination (Group 2), and 23 eyes from healthy individuals (Group 3). Superficial, deep, and radial peripapillary capillary plexus vascular density (SCP-vd, DCP-vd, RPCP-vd) and foveal avascular zone (FAZ) measurements were taken with OCT-A. The comparative analysis between groups was performed with SPSS V.26.</p><p><strong>Results: </strong>Across the groups (from 1 to 3), whole image vascular density (vd) measurements were as follows: SCP-vd: 45.86 ± 3.99, 44.58 ± 4.58, 48.35 ± 4.04; DCP-vd: 44.86 ± 5.75, 44.02 ± 6.87, 49.74 ± 4.84; and RPCP-vd: 46.97 ± 3.81, 47.07 ± 5.49, 49.90 ± 2.43. All these measurements were significantly decreased in both glaucoma groups (groups 1 and 2) compared to healthy subjects (group 3). In subgroup analyses of the macular region, including the fovea, parafovea, and perifovea, vd measurements were decreased in all areas except the fovea in glaucoma patients. However, no statistically significant differences were found between the latanoprost and dorzolamide-timolol groups regarding retinal vascular structure. In FAZ measurements, no significant differences were found in any anatomical location among the three groups.</p><p><strong>Conclusion: </strong>This study demonstrates that latanoprost, the first prostaglandin analog known for its edema-inducing effect on the macula, does not have a long-term impact on macular vascularity. However, this result should be supported with longer and larger studies.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"188"},"PeriodicalIF":1.4,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundus fluorescein angiography findings in eyes initially diagnosed with idiopathic epiretinal membrane.","authors":"Chen Chen, Qi Zhang, Linrui Li, Xiaoyan Ding, Lin Lu, Xiujuan Zhao","doi":"10.1007/s10792-025-03542-1","DOIUrl":"https://doi.org/10.1007/s10792-025-03542-1","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to investigate the fundus fluorescein angiography (FFA) findings in eyes initially diagnosed with idiopathic epiretinal membrane (iERM) and assess their impact on best-corrected visual acuity (BCVA).</p><p><strong>Methods: </strong>This retrospective comparative study included 136 patients (151 eyes) diagnosed with iERM and a control group of 121 healthy fellow eyes. All patients underwent FFA and optical coherence tomography (OCT). The primary outcomes summarized the characteristics of FFA and OCT in patients with iERM, and analyzed the relationship between FFA findings and visual acuity.</p><p><strong>Results: </strong>Vascular leakage (P = 0.009) were significantly more prevalent in eyes with iERM compared to controls. Multivariate logistic regression analysis indicated that optic disc hyperfluorescence (OR 4.05; 95% CI 1.79-9.17; P = 0.001) were more likely to present in eyes with iERM. A lower OCT stage, fovea-recognizable, cellophane macular reflex type were associated with better BCVA.</p><p><strong>Conclusion: </strong>Optic disc hyperfluorescence is independent risk factors of iERM. Howerer, these abnormalities do not show a significant association with visual function. The precise etiology remains to be fully elucidated.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"184"},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluatıon of the protective role of melatonın ın methanol ınduced optıc neuropathy.","authors":"Şerife Gülhan Konuk, Süleyman Özdemir, Raşit Kılıç, Gamze Bektur, Alper Güneş, Ender Şener","doi":"10.1007/s10792-025-03539-w","DOIUrl":"https://doi.org/10.1007/s10792-025-03539-w","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of intraperitoneal melatonin administration on the optic nerve and retina following acute methanol exposure.</p><p><strong>Materials and methods: </strong>Twenty-four female albino Wistar rats weighing 200-300 g and aged between 3 and 6 months were utilized. The rats were divided into three groups, each consisting of eight rats: healthy control (C), methanol (M), and methanol + melatonin (MM) groups. Initially, rats in groups M and MM were administered intraperitoneal methotrexate at a dose of 0.3 mg/kg. One week later, the same groups were orally given methanol at a concentration of 20% and a dose of 3 g/kg to induce methanol toxicity. To ensure survival, four hours after oral methanol administration, ethanol was orally administered at a concentration of 20% and a dose of 0.5 g/kg. Additionally, starting from the next day, the MM group received intraperitoneal melatonin at a dose of 20 mg/kg/day for 14 days. On the 14th day, rats were sacrificed, and their eyes, including the optic nerves, were enucleated for histopathological examinations. Myelin basic protein (MBP), retinal ganglion cell (RGC), glial cell degeneration and optic nerve thickness were evaluated.</p><p><strong>Results: </strong>The experiment was completed with a total of twenty-four rats, with each group consisting of eight rats. When evaluating RGC, glial cell degeneration, and optic nerve thickness, the results for Group MM were significantly better than those for Group M (p < 0.0001, p < 0.0001, p < 0.0001, respectively). There was no significant difference between Group MM and Group C, which was not subjected to alcohol intoxication (p: 0.89, p: 0.82, p: 0.77, respectively). There was no significant difference in MBP values ​​between the groups (p: 0.44, p: 0.17, p: 0.80, respectively).</p><p><strong>Conclusion: </strong>Intraperitoneal administration of melatonin has a significant positive effect on the structure of the retina and optic nerve resulting from methanol exposure. Melatonin should be considered in future studies as a potential therapy for methanol-induced toxic optic neuropathy.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"182"},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of blepharoptosis surgery on vision-related quality of life and its correlation with contrast sensitivity changes.","authors":"M C Bruzual-Lezama, P Peña-Urbina, C Berrozpe-Villabona, N Ibáñez-Flores","doi":"10.1007/s10792-025-03563-w","DOIUrl":"https://doi.org/10.1007/s10792-025-03563-w","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the correlation between contrast sensitivity changes and post-surgical improvement in visual function perception and health-related quality of life among patients with blepharoptosis.</p><p><strong>Methods: </strong>This prospective cohort studied 55 patients with blepharoptosis surgical indication, one eye per patient was considered for analysis. Refraction, visual acuity (VA), eyelash ptosis and contrast sensitivity (CS) test were evaluated. The National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ25), concerning vision-related activities and symptoms, was used to assess the patient´s quality of life pre and postoperatively. Patients were analyzed globally and divided according to the severity of ptosis, lens opacity and the co-existence of glaucoma.</p><p><strong>Results: </strong>55 eyes underwent ptosis surgery. VA significantly improved without notable refractive changes (p = 0.0044). CS demonstrated significant enhancement in all patients and groups. The NEI-VFQ 25 overall score significantly improved from baseline to 3 months postoperatively (p < 0.001). General vision (p = 0.0319), near and peripheral vision (p < 0.001 and p = 0.0188, respectively), color vision (0.0177), ocular pain (p < 0.001), dependence (p = 0.0093) and mental health (p = 0.0341) exhibited significant improvement. All groups experienced a significant increase in the overall score postoperatively. They all concurred on the improvement of the subscale near vision, except for the glaucoma group, which showed no improvement in either of the subscales.</p><p><strong>Conclusion: </strong>Ptosis surgery significantly improves contrast sensitivity, visual function, and quality of life in patients, including those with ocular comorbidities such as lens opacity and glaucoma. NEI-VFQ 25 assessment revealed an important enhancement in near and peripheral vision, ocular pain, and dependence; which highlight the broad benefits of the surgery, increasing autonomy in daily activities.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"187"},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering hemorrhagic risks in external dacryocystorhinostomy: a comprehensive analysis of associated factors.","authors":"Bita Karimi, Masoomeh Eghtedari, Behzad Khademi, Mohammad Hossein Nowroozzadeh","doi":"10.1007/s10792-025-03544-z","DOIUrl":"https://doi.org/10.1007/s10792-025-03544-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the impact of herbs (Ginger, Garlic and Green tea) and perioperative factors on intraoperative and postoperative hemorrhage as well as ecchymosis in external dacryocystorhinostomy.</p><p><strong>Methods: </strong>This was a case series study that included 50 external DCR procedures performed on adults. Patients' herbal use and other risk factors were questioned before the surgery. During the procedure, intraoperative hemorrhage volume and other parameters were documented. Postoperative hemorrhage and ecchymosis were evaluated on the day following the surgery. We used Regression analysis to assess the factors associated with hemorrhage complications in external DCR.</p><p><strong>Results: </strong>The average amount of intraoperative hemorrhage was 81.66 ml. Moderate to severe postoperative hemorrhage and ecchymosis occurred in 27.7 and 40.8% of cases, respectively. Upon conducting linear regression analysis, intraoperative MAP was the only factor associated with intraoperative hemorrhage. A significant association of ginger and intraoperative MAP with postoperative hemorrhage was revealed through multiple regression analysis. Additionally, the factors associated with postoperative ecchymosis were older age and urban residence.</p><p><strong>Conclusions: </strong>We identified several factors associated with hemorrhage complications in external DCR procedure, including ginger use, intraoperative MAP, older age, and urban residence. Based on our findings that ginger intake before surgery can increase the hemorrhage risk, patients should be meticulously questioned about ginger use prior to external DCR and be recommended to cease its use.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"185"},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-infectious uveitis: a multicenter study from Argentina.","authors":"Belén María Virasoro, Alex Kostianovsky, Florencia Milesi, Marcela Bellón, Víctor Morales Roldan, Liliana Martínez, Emmanuel Bertiller, Milagros Heredia, Paula Aquino, Luz María De Zavalia, Luis Zeman, Santiago Catalán Pellet, María Marcela García, Marcelo Bursztyn, Eliana Flavia Emma Segretin Gutiérrez, Leandro Ferreyra Garrott, Eduardo Jorge Premoli, Javier Eduardo Rosa, Enrique Roberto Soriano, María Beatriz Marcantoni, Sebastián Andrés Muñoz, Ramiro Adrian Gómez, Andrea Smichowski, Federico Ceccato, Sophia Lutgen, Ariana Ringer, Silvina Auteri, Gustavo Budmann, Emilio María Dodds, Ariel Schlaen, Ignacio Javier Gandino","doi":"10.1007/s10792-025-03555-w","DOIUrl":"10.1007/s10792-025-03555-w","url":null,"abstract":"<p><strong>Purpose: </strong>To describe etiologies and clinical characteristics of patients from Argentina with non-infectious uveitis (NIU). Differences between the anatomic segments involved were described as well.</p><p><strong>Methods: </strong>This is a multicentric, cross-sectional study from January 2008 to March 2021. We included patients with NIU from private and public institutions. Uveitis diagnosis was made by ophthalmologists specializing in uveitis, and rheumatologists diagnosed the autoimmune conditions. Patients were classified according to the International Uveitis Study Group classification system. RESULTS°: We included 468 patients with NIU. Most of them were female (64.1%), with a mean age at diagnosis of 37.9 years (SD 17.2). Idiopathic uveitis and Vogt-Koyanagi-Harada disease (VKH) were the most frequent causes. Among anterior uveitis, the most prevalent causes were idiopathic, spondyloarthritis, juvenile idiopathic arthritis, and sarcoidosis. VKH and Behçet were predominant within the panuveitis group. Over half of the patients (57%) required immunosuppressants. Methotrexate (20.6%) and azathioprine (8.9%) were mostly used. Eleven percent of the patients needed biologics, mostly adalimumab (9.4%). Two hundred fifty-six (54.7%) patients had eye complications, and cataracts were the most frequent (30%). A comparative analysis was performed between public and private institutions. There was no difference in the causes of uveitis or complications (p = 0.38; p = 0.06, respectively).</p><p><strong>Conclusion: </strong>The most prevalent causes of uveitis were VKH and idiopathic uveitis, different from the etiologies observed in the United States and Europe.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"186"},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-6837-3p protected retinal epithelial cells from oxidative stress by targeting E2F6.","authors":"Xin Zhao, Xinru Chen, Xiangyang Xin","doi":"10.1007/s10792-025-03540-3","DOIUrl":"https://doi.org/10.1007/s10792-025-03540-3","url":null,"abstract":"<p><strong>Aim: </strong>The mechanism of age-related macular degeneration (AMD) is a complex illness that is not fully understood. Therefore, the aim of this study was to investigate the expression patterns of miR-6837-3p in retinal epithelial cells.</p><p><strong>Methods: </strong>H₂O₂ was used to treat ARPE-19 cells for 2, 4 and 6 h to mimic the in vivo environment of AMD. MiR inhibitors and mimics were used to inhibit or overexpress miR-6837-3p in H₂O₂-treated ARPE-19 cells, respectively. Then, CCK8 assay, flow cytometry, and wound healing assays were conducted to assess the effects of miR-6837-3p on the behaviors of ARPE-19 cells, including cell growth, apoptosis, cycle progression, and migration. Finally, microRNA database prediction and luciferase reporter assays were used to demonstrate that miR-6837-3p targets the downstream gene E2F6.</p><p><strong>Results: </strong>H₂O₂ induced a decrease in cell viability and an increase in ROS levels in a time-dependent manner. Additionally, overexpression of miR-6837-3p increased cell viability and suppressed apoptosis in ARPE-19 cells treated with H₂O₂. Meanwhile, increased miR-6837-3p promoted cell cycle progression and cell migration of ARPE-19 cells. Finally, miR-6837-3p exerted anti-apoptosis and anti-oxidative stress effects by inhibiting the expression of E2F6 in ARPE-19 cells.</p><p><strong>Conclusions: </strong>The MiR-6837-3p/E2F6 axis might be a target for the treatment of AMD to improve ARPE-19 cell function.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"183"},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the choroidal vascularity index and choroidal thickness in patients with systemic sclerosis.","authors":"Esra Vural, Kemal Erol, Nurettin Bayram, Samet Karahan, Medine Gündoğan, Leyla Hazar","doi":"10.1007/s10792-025-03536-z","DOIUrl":"https://doi.org/10.1007/s10792-025-03536-z","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the choroidal structural components using central macular thickness (CMT), choroidal thickness (CT) and the choroidal vascular index (CVI) and compare the results between patients with systemic sclerosis (SSc), causing both fibrotic and angiopathic changes in tissues and healthy controls.</p><p><strong>Methods: </strong>This prospective comparative study evaluated 22 patients with SSc (SSc group). The patients' choroidal thickness, CVI and choroidal area (CA) were compared with 21 healthy controls (control group). The patients' nailfold videocapillaroscopy (NVC) and modified Rodnan skin score (mRss) were evaluated by expert rheumatologists. In addition, the relationships between choroidal findings and NVC and mRss were assessed.</p><p><strong>Results: </strong>The central macular thickness in the SSc and control groups was 269.47 ± 26.78 µm and 261.19 ± 17.09 µm, respectively (p = 0.093). The subfoveal choroidal thickness was 295.38 ± 33.70 μm and 322.16 ± 70.24 μm, respectively (p = 0.026); the temporal choroidal thickness was 246.77 ± 21.83 μm and 265.26 ± 52.34 μm, respectively (p = 0.034); and the nasal choroidal thickness was 135.36 ± 28.10 μm and 158.88 ± 49.16 μm, respectively (p = 0.008). Total CA of 1.5 mm region centered on the fovea was 0.49 ± 0.08 mm² and 0.55 ± 0.09 mm², respectively (p = 0.002); total CVI of 1.5 mm region centered on the fovea was 63.66% ± 1.23 and 64.90% ± 1.07, respectively (p < 0.001); total CA of 6 mm region centered on the fovea was 1.61 ± 0.22 mm² and 1.80 ± 0.33 mm², respectively (p = 0.003); the total CVI of 6 mm region centered on the fovea was 63.85% ± 1.16 and 64.87% ± 1.12, respectively (p < 0.001). There was no correlation between mRss score and Raynaud severity and CMT, CVI and CTs; however, there was a positive correlation between the mRss and the Raynaud severity (p = 0.0004, r = 0.507).</p><p><strong>Conclusion: </strong>This study found that choroidal thickness and CVI decreased in SSc patients. A decrease in CVI may be an indicator of damage, especially in luminal structures.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"181"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}